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In this paper, I explore socio-spatial segregation from a particular perspective, which may probably be considered a novelty in the investigation of spatial social patterns, as it focuses on questions such as: What kind of distinction occurs between socio-spatial patterns designated by statistical data and the cognitive representations of those patterns in people’s minds? And what explains these differences, and what kind of impact can they generate?

The European cultural landscape and its traditional values represent a significant condition for recreation and tourism. However, we are aware of the negative consequences of human activity in the past years in rural areas and pay more attention to protecting these values. Modern rural recreation and tourism must be built on scientific background. That is why the presented contribution brings an innovative integrated approach to sustainable rural recreation and tourism model by applying landscape ecological planning methodology with a combination of ecological stability and landscape character assessment. It deals with the qualitative evaluation of the landscape potential of the foothill village of Podkonice in Slovakia and the possibilities of its use in sustainable rural tourism. Determining the potential in confrontation with different forms of tourism activities can help achieve a sustainable tourism concept. The main result of the presented research is the final optimal selection of activities and use of the landscape with regard to the development of tourism. Such a proposal can be used in spatial planning and strategic decision-making processes not only in the study area, but it can be applied in the European context.

Public participation is increasingly important in flood and environmental management planning. Accordingly , understanding the attitude of local society to natural values and their relations with the environment is highly important to realize successful development projects. This study aimed to analyze the human-nature relationship, the public perceptions of environmental hazards and people's engagement with water management related and human interventions at Maros/Mureş River through a public survey. The survey was carried out in 11 Romanian and Hungarian settlements using the random walking method to interview the local public. The results show that people are a little pessimistic concerning the state of the river, and there are misbeliefs about the general problems affecting its present environmental status. Meanwhile, the perception of flood hazard is governed by the fading memory of the last high-risk flood event in 1970. The engagement of residents is mostly affected by socio-demographic parameters. However, the regularity they visit the river is also very important. Consequently, informing people on apparent environmental issues and processes can greatly help the socially inclusive implementation of water management measures along the river.

This research examined the effectiveness of zinc foliar fertilizers. Two winter wheat varieties, GK Pilis and Zvezdana, were tested in a Zn-limited meadow chernozem soil. Crop yields and chlorophyll concentrations of the leaves were examined in the growing seasons of 2020/2021 of favorable weather conditions and 2021/2022 of drought weather conditions. In the experiment, three treatments were carried out with monozinc foliar fertilizer of a concentrated 12% (w/v) zinc sulfate heptahydrate solution, and the fourth plot was designed as the untreated control. The first monozinc treatment was applied at a dose of 1 L ha−1 and the second monozinc treatment at a dose of 2 L ha−1. These treatments were applied at tillering (BBCH 21–22). The third monozinc treatment was applied at a dose of 1 L ha−1 at tillering and flag leaf emergence (BBCH 21–22, BBCH 37). Samples were taken several times in the vegetation period, and measurements were made using different methods (SPAD, determination of total chlorophyll concentration from acetone solution) before and after Zn treatments. In 2020/2021 of favorable weather conditions, the yield of Zvezdana was 5.47 t ha−1 and that of Gk Pilis was 6.11 t ha−1, compared to 2021/2022 of drought weather conditions, in which year the yield of Zvezdana was 3.14 t ha−1 and that of Gk Pilis was 2.79 t ha−1. Yields of both varieties increased with increasing NPK nutrient doses. In 2021/2022, even at nutrient level D (NPK basal fertilizer and two-times N topdressing), we harvested on average twice as much as in 2020/2021 at nutrient level A (N basal fertilizer and once N topdressing). No significant effects were found between the foliar fertilizers in 2020/2021. In 2021/2022, Zn treatments, mainly at four nutrient levels tended to increase the yields of both varieties. The first treatment resulted in a grain yield reduction of 3% for GK Pilis, and the second treatment resulted in a grain yield reduction of 1.2% for Zvezdana. After the second and third treatments, grain yield reductions were 0.1%–0.5%. Although there was no significant difference in terms of the main averages, foliar fertilizer was found to be effective in the second year. The relationship between chlorophyll and grain yield was found to depend on the year and variety. A weak correlation (r = 0.33, p < 0.05) was found between the total chlorophyll concentration in leaves for Zvezdana in 2021, and a medium correlation for GK Pilis (r = 0.67, p < 0.05). Concerning grain yield and chlorophyll concentration, a strong correlation (r = 0.81, p < 0.05) was found for Zvezdana in 2022, and a weak correlation (r = 0.44, p < 0.05) for GK Pilis. A strong correlation was found between the total leaf chlorophyll concentration and SPAD index in both years (r = 0.81, p < 0.05) [ABSTRACT FROM AUTHOR]

The data acquisition system (DAQ) of the CMS experiment at the CERN Large Hadron Collider (LHC) assembles events of 2MB at a rate of 100 kHz. The event builder collects event fragments from about 750 sources and assembles them into complete events which are then handed to the High-Level Trigger (HLT) processes running on O(1000) computers. The aging eventbuilding hardware will be replaced during the long shutdown 2 of the LHC taking place in 2019/20. The future data networks will be based on 100 Gb/s interconnects using Ethernet and Infiniband technologies. More powerful computers may allow to combine the currently separate functionality of the readout and builder units into a single I/O processor handling simultaneously 100 Gb/s of input and output traffic. It might be beneficial to preprocess data originating from specific detector parts or regions before handling it to generic HLT processors. Therefore, we will investigate how specialized coprocessors, e.g. GPUs, could be integrated into the event builder. We will present the envisioned changes to the event-builder compared to today’s system. Initial measurements of the performance of the data networks under the event-building traffic pattern will be shown. Implications of a folded network architecture for the event building and corresponding changes to the software implementation will be discussed.

The Compact Muon Solenoid (CMS) is one of the experiments at the CERN Large Hadron Collider (LHC). The CMS Online Monitoring system (OMS) is an upgrade and successor to the CMS Web-Based Monitoring (WBM)system, which is an essential tool for shift crew members, detector subsystem experts, operations coordinators, and those performing physics analyses. The CMS OMS is divided into aggregation and presentation layers. Communication between layers uses RESTful JSON:API compliant requests. The aggregation layer is responsible for collecting data from heterogeneous sources, storage of transformed and pre-calculated (aggregated) values and exposure of data via the RESTful API. The presentation layer displays detector information via a modern, user-friendly and customizable web interface. The CMS OMS user interface is composed of a set of cutting-edge software frameworks and tools to display non-event data to any authenticated CMS user worldwide. The web interface tree-like component structure comprises (top-down): workspaces, folders, pages, controllers and portlets. A clear hierarchy gives the required flexibility and control for content organization. Each bottom element instantiates a portlet and is a reusable component that displays a single aspect of data, like a table, a plot, an article, etc. Pages consist of multiple different portlets and can be customized at runtime by using a drag-and-drop technique. This is how a single page can easily include information from multiple online sources. Different pages give access to a summary of the current status of the experiment, as well as convenient access to historical data. This paper describes the CMS OMS architecture, core concepts and technologies of the presentation layer.

Generation of fast network oscillations in the hippocampus relies on interneurons, but the underlying specific synaptic mechanisms are not established. The excitatory recruitment of fast-spiking interneurons during hippocampal sharp waves has been suggested to be critical for the generation of 140 -200 Hz ("ripple") oscillations in the CA1 area. To directly test this, we used genetically modified mice (PV-ΔGluR-A) with reducedAMPAreceptor-mediated excitation onto parvalbumin (PV)-positive interneurons and studied hippocampal oscillations in freely moving animals. InPV-ΔGluR-A mice, ripple-amplitude and associated rhythmic modulation of pyramidal cells and fast-spiking interneurons were increased. These changes were not accompanied by concurrent alterations of firing rates. Neither theta nor gamma oscillations displayed marked alterations in the mutant. These results provide evidence that fast excitation from pyramidal cells to PV-positive interneurons differentially influences ripple and gamma oscillations in vivo. [ABSTRACT FROM AUTHOR]

When errors in messenger RNA processing or packaging occur along the path from the site of transcription to the nuclear pore complex, the conserved RNA-degrading enzyme Swt1 comes into the game. [ABSTRACT FROM AUTHOR]

Generation of fast network oscillations in the hippocampus relies on interneurons, but the underlying specific synaptic mechanisms are not established. The excitatory recruitment of fast-spiking interneurons during hippocampal sharp waves has been suggested to be critical for the generation of 140 -200 Hz ("ripple") oscillations in the CA1 area. To directly test this, we used genetically modified mice (PV-ΔGluR-A) with reduced AMPA receptor-mediated excitation onto parvalbumin (PV)-positive interneurons and studied hippocampal oscillations in freely moving animals. InPV-ΔGluR-A mice, ripple-amplitude and associated rhythmic modulation of pyramidal cells and fast-spiking interneurons were increased. These changes were not accompanied by concurrent alterations of firing rates. Neither theta nor gamma oscillations displayed marked alterations in the mutant. These results provide evidence that fast excitation from pyramidal cells to PV-positive interneurons differentially influences ripple and gamma oscillations in vivo. [ABSTRACT FROM AUTHOR]

Yra1p and Sub2p are components of the TREX complex, which couples transcription elongation with nuclear export of mRNAs. Here, we report a genetic interaction between Yra1p and a conserved protein Sac3p, which previously was found to interact with Sub2p. In vivo, Sac3p forms a stable complex with Thp1p, which was reported to function in transcription elongation. In addition, Sac3p binds to the mRNA exporter Mex67p-Mtr2p and requires the nucleoporin Nupip to dock at the nuclear side of the nuclear pore complex (NPC). Significantly, mutations in Sac3p or Thp1p lead to strong mRNA export defects. Taken together, our data suggest that the novel Sac3p-Thp1p complex functions by docking the mRNP to specific nucleoporins at the nuclear entrance of the NPC. [ABSTRACT FROM AUTHOR]

Heat shock protein 90 (Hsp90) is a molecular chaperone required for the activity of many of the most important regulatory proteins of eukaryotic cells (the Hsp90 'clients'). Vertebrates have two isoforms of cytosolic Hsp90, Hsp90alpha and Hsp90beta. Hsp90beta is expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90alpha, whereas Hsp90alpha is stress-inducible and overexpressed in many cancerous cells. Expressed as the sole Hsp90 of yeast, human Hsp90alpha and Hsp90beta are both able to provide essential Hsp90 functions. Activations of certain Hsp90 clients (heat shock transcription factor, v-src) were more efficient with Hsp90alpha, rather than Hsp90beta, present in the yeast. In contrast, activation of certain other clients (glucocorticoid receptor; extracellular signal-regulated kinase-5 mitogen-activated protein kinase) was less affected by the human Hsp90 isoform present in these cells. Remarkably, whereas expression of Hsp90beta as the sole Hsp90 of yeast rendered cells highly sensitive to the Hsp90 inhibitor radicicol, comparable expression of Hsp90alpha did not. This raises the distinct possibility that, also for mammalian systems, alterations to the Hsp90alpha/Hsp90beta ratio (as with heat shock) might be a significant factor affecting cellular susceptibility to Hsp90 inhibitors.