38 results on '"Pulido-Valdeolivas, Irene"'
Search Results
2. Multiscale networks in multiple sclerosis
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Kennedy, Keith E., primary, Kerlero de Rosbo, Nicole, additional, Uccelli, Antonio, additional, Cellerino, Maria, additional, Ivaldi, Federico, additional, Contini, Paola, additional, De Palma, Raffaele, additional, Harbo, Hanne F., additional, Berge, Tone, additional, Bos, Steffan D., additional, Høgestøl, Einar A., additional, Brune-Ingebretsen, Synne, additional, de Rodez Benavent, Sigrid A., additional, Paul, Friedemann, additional, Brandt, Alexander U., additional, Bäcker-Koduah, Priscilla, additional, Behrens, Janina, additional, Kuchling, Joseph, additional, Asseyer, Susanna, additional, Scheel, Michael, additional, Chien, Claudia, additional, Zimmermann, Hanna, additional, Motamedi, Seyedamirhosein, additional, Kauer-Bonin, Josef, additional, Saez-Rodriguez, Julio, additional, Rinas, Melanie, additional, Alexopoulos, Leonidas G., additional, Andorra, Magi, additional, Llufriu, Sara, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, Martinez-Heras, Eloy, additional, Solana, Elisabeth, additional, Pulido-Valdeolivas, Irene, additional, Martinez-Lapiscina, Elena H., additional, Garcia-Ojalvo, Jordi, additional, and Villoslada, Pablo, additional
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- 2024
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3. MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis
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Kotelnikova, Ekaterina, Kiani, Narsis A., Messinis, Dimitris, Pertsovskaya, Inna, Pliaka, Vicky, Bernardo-Faura, Marti, Rinas, Melanie, Vila, Gemma, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Sakellaropoulos, Theodore, Faigle, Wolfgang, Silberberg, Gilad, Masso, Mar, Stridh, Pernilla, Behrens, Janina, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Alexopoulos, Leonidas G., Saez-Rodriguez, Julio, Tegner, Jesper, and Villoslada, Pablo
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- 2019
4. Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial
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Zubizarreta, Irati, Flórez-Grau, Georgina, Vila, Gemma, Cabezón, Raquel, España, Carolina, Andorra, Magi, Saiz, Albert, Llufriu, Sara, Sepulveda, Maria, Sola-Valls, Nuria, Martinez-Lapiscina, Elena H., Pulido-Valdeolivas, Irene, Casanova, Bonaventura, Gines, Marisa Martinez, Tellez, Nieves, Oreja-Guevara, Celia, Español, Marta, Trias, Esteve, Cid, Joan, Juan, Manel, Lozano, Miquel, Blanco, Yolanda, Steinman, Lawrence, Benitez-Ribas, Daniel, and Villoslad, Pablo
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- 2019
5. Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
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Solana, Elisabeth, Martinez-Heras, Eloy, Montal, Victor, Vilaplana, Eduard, Lopez-Soley, Elisabet, Radua, Joaquim, Sola-Valls, Nuria, Montejo, Carmen, Blanco, Yolanda, Pulido-Valdeolivas, Irene, Sepúlveda, Maria, Andorra, Magi, Berenguer, Joan, Villoslada, Pablo, Martinez-Lapiscina, E. H., Prados, Ferran, Saiz, Albert, Fortea, Juan, and Llufriu, Sara
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- 2021
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6. Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation
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Villoslada, Pablo, Vila, Gemma, Colafrancesco, Valeria, Moreno, Beatriz, Fernandez-Diez, Begoña, Vazquez, Raquel, Pertsovskaya, Inna, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Messeguer, Joaquin, Vendrell-Navarro, Gloria, Frade, Jose Maria, López-Sánchez, Noelia, Teixido, Meritxell, Giralt, Ernest, Masso, Mar, Dugas, Jason C, Leonoudakis, Dmitri, Lariosa-Willingham, Karen D., Steinman, Lawrence, and Messeguer, Angel
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- 2019
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7. Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years
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Pulido-Valdeolivas, Irene, Andorrà, Magí, Gómez-Andrés, David, Nakamura, Kunio, Alba-Arbalat, Salut, Lampert, Erika J., Zubizarreta, Irati, Llufriu, Sara, Martinez-Heras, Eloy, Solana, Elisabeth, Sola-Valls, Nuria, Sepulveda, María, Tercero-Uribe, Ana, Blanco, Yolanda, Camos-Carreras, Anna, Sanchez-Dalmau, Bernardo, Villoslada, Pablo, Saiz, Albert, and Martinez-Lapiscina, Elena H.
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- 2020
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8. Late-onset neuromyelitis optica spectrum disorder: The importance of autoantibody serostatus
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Sepulveda, Maria, Delgado-García, Guillermo, Blanco, Yolanda, Sola-Valls, Nuria, Martinez-Lapiscina, Elena H., Armangué, Thaís, Montejo, Carmen, Pulido-Valdeolivas, Irene, Martinez-Hernandez, Eugenia, Ariño, Helena, Escudero, Domingo, Ruiz-García, Raquel, Llufriu, Sara, Dalmau, Josep, Graus, Francesc, and Saiz, Albert
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- 2019
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9. Toward an Automatic Assessment of Cognitive Dysfunction in Relapsing–Remitting Multiple Sclerosis Patients Using Eye Movement Analysis
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García Cena, Cecilia E., primary, Gómez-Andrés, David, additional, Pulido-Valdeolivas, Irene, additional, Sánchez-Seco, Victoria Galán, additional, Domingo-Santos, Angela, additional, Moreno-García, Sara, additional, and Benito-León, Julián, additional
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- 2022
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10. Metabolomic signatures associated with disease severity in multiple sclerosis
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Villoslada, Pablo, Alonso, Cristina, Agirrezabal, Ion, Kotelnikova, Ekaterina, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Saiz, Albert, Comabella, Manuel, Montalban, Xavier, Villar, Luisa, Alvarez-Cermeño, Jose Carlos, Fernández, Oscar, Alvarez-Lafuente, Roberto, Arroyo, Rafael, and Castro, Azucena
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- 2017
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11. Gait analysis under the lens of statistical physics
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European Research Council, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), ONCE, Zanin, Massimiliano, Olivares, Felipe, Pulido-Valdeolivas, Irene, Rausell, Estrella, Gomez-Andres, David, European Research Council, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), ONCE, Zanin, Massimiliano, Olivares, Felipe, Pulido-Valdeolivas, Irene, Rausell, Estrella, and Gomez-Andres, David
- Abstract
Human gait is a fundamental activity, essential for the survival of the individual, and an emergent property of the interactions between complex physical and cognitive processes. Gait is altered in many situations, due both to external constraints, as e.g. paced walk, and to physical and neurological pathologies. Its study is therefore important as a way of improving the quality of life of patients, but also as a door to understanding the inner working of the human nervous system. In this review we explore how four statistical physics concepts have been used to characterise normal and pathological gait: entropy, maximum Lyapunov exponent, multi-fractal analysis and irreversibility. Beyond some basic definitions, we present the main results that have been obtained in this field, as well as a discussion of the main limitations researchers have dealt and will have to deal with. We finally conclude with some biomedical considerations and avenues for further development.
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- 2022
12. Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis
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Lopez-Soley, Elisabet, primary, Martinez-Heras, Eloy, additional, Andorra, Magi, additional, Solanes, Aleix, additional, Radua, Joaquim, additional, Montejo, Carmen, additional, Alba-Arbalat, Salut, additional, Sola-Valls, Nuria, additional, Pulido-Valdeolivas, Irene, additional, Sepulveda, Maria, additional, Romero-Pinel, Lucia, additional, Munteis, Elvira, additional, Martínez-Rodríguez, Jose E., additional, Blanco, Yolanda, additional, Martinez-Lapiscina, Elena H., additional, Villoslada, Pablo, additional, Saiz, Albert, additional, Solana, Elisabeth, additional, and Llufriu, Sara, additional
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- 2021
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13. In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis
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Alba-Arbalat, Salut, primary, Andorra, Magi, additional, Sanchez-Dalmau, Bernardo, additional, Camos-Carreras, Anna, additional, Dotti-Boada, Marina, additional, Pulido-Valdeolivas, Irene, additional, Llufriu, Sara, additional, Blanco, Yolanda, additional, Sepulveda, Maria, additional, Saiz, Albert, additional, Batet, Oscar, additional, Bilbao, Iker, additional, Torre, Iratxe, additional, Amat-Roldan, Ivan, additional, Martinez-Lapiscina, Elena H., additional, and Villoslada, Pablo, additional
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- 2021
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14. Incidence and impact of COVID-19 in MS. A survey from a Barcelona MS Unit.
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Universitat Politècnica de Catalunya. Doctorat en Física Computacional i Aplicada, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos, Sepúlveda, Maria, Llufriu, Sara, Martínez-Hernández, Eugenia, Català Sabaté, Martí, Artola, Montse, Hernando, Ana, Montejo, Carmen, Pulido-Valdeolivas, Irene, Martinez-Heras, Eloy, Guasp, Mar, Solana, Elisabeth, Llançó, Laura, Escudero, Domingo, Aldea, Marta, Prats Soler, Clara, Graus Ribas, Francesc, Blanco, Yolanda, Saiz, Albert, Universitat Politècnica de Catalunya. Doctorat en Física Computacional i Aplicada, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos, Sepúlveda, Maria, Llufriu, Sara, Martínez-Hernández, Eugenia, Català Sabaté, Martí, Artola, Montse, Hernando, Ana, Montejo, Carmen, Pulido-Valdeolivas, Irene, Martinez-Heras, Eloy, Guasp, Mar, Solana, Elisabeth, Llançó, Laura, Escudero, Domingo, Aldea, Marta, Prats Soler, Clara, Graus Ribas, Francesc, Blanco, Yolanda, and Saiz, Albert
- Abstract
Objective: To investigate the incidence of coronavirus disease 2019 (COVID-19) in a single-center cohort of patients with MS and to explore the contribution of their comorbidities and therapies to the outcome. Methods: A cross-sectional mixed-method study was conducted involving an email-based, self-administered questionnaire sent on May 21, 2020, to 586 patients with MS followed at the MS Unit of Hospital Clinic, University of Barcelona, along with telephone interview, and review of electronic medical records until June 18, 2020. The cumulative incidence of confirmed COVID-19 (positive PCR or antibody test) and all COVID-19 cases (confirmed and suspected) from the start of the pandemic was compared with the population estimates for Barcelona. Results: A total of 407 patients (69.5%) completed the survey. Most of the responders (67%) were female. The responders had a median age of 48 years (range 19–86), relapsing-remitting disease (84%), at least 1 comorbidity (45%), and were on disease-modifying therapy (DMT; 74.7%). COVID-19 was confirmed in 5 patients (1.2%) and suspected in 46 (11.3%). The cumulative incidence of confirmed COVID-19 cases was similar to that of the general population but was almost 2-fold higher when all cases were considered (p < 0.001). Six patients (11.7%) were hospitalized, of which 5 had good recovery and 1 died. Hospitalized patients were more frequently male, had diabetes and had progressive forms of MS (p < 0.05). DMT was not associated with the risk of infection or the outcome. Conclusions: In the studied MS cohort, the incidence of COVID-19 was higher than that of the general population; however, most patients did not require hospitalization and had a good outcome despite the frequent presence of comorbidities and treatment with DMT., Peer Reviewed, Postprint (published version)
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- 2021
15. Dynamics and predictors of cognitive impairment along the disease course in multiple sclerosis
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Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, López Soley, Elisabet, Martinez-Heras, Eloy, Andorra, Magi, Solanes Font, Aleix, Radua, Joaquim, Montejo, Carmen, Alba Arbalat, Salut, Sola Valls, Núria, Pulido-Valdeolivas, Irene, Sepúlveda, Maria, Romero Pinel, Lucia, Munteis Olivas, Elvira, Martínez Rodríguez, Jose Enrique, Blanco, Yolanda, Martínez Lapiscina, Elena H., Villoslada, Pablo, Saiz Hinarejos, Albert, Solana, Elisabeth, Llufriu, Sara, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, López Soley, Elisabet, Martinez-Heras, Eloy, Andorra, Magi, Solanes Font, Aleix, Radua, Joaquim, Montejo, Carmen, Alba Arbalat, Salut, Sola Valls, Núria, Pulido-Valdeolivas, Irene, Sepúlveda, Maria, Romero Pinel, Lucia, Munteis Olivas, Elvira, Martínez Rodríguez, Jose Enrique, Blanco, Yolanda, Martínez Lapiscina, Elena H., Villoslada, Pablo, Saiz Hinarejos, Albert, Solana, Elisabeth, and Llufriu, Sara
- Abstract
Background: The evolution and predictors of cognitive impairment (CI) in multiple sclerosis (MS) are poorly understood. We aimed to define the temporal dynamics of cognition throughout the disease course and identify clinical and neuroimaging measures that predict CI. (2) Methods: This paper features a longitudinal study with 212 patients who underwent several cognitive examinations at different time points. Dynamics of cognition were assessed using mixed-effects linear spline models. Machine learning techniques were used to identify which baseline demographic, clinical, and neuroimaging measures best predicted CI. (3) Results: In the first 5 years of MS, we detected an increase in the z-scores of global cognition, verbal memory, and information processing speed, which was followed by a decline in global cognition and memory (p < 0.05) between years 5 and 15. From 15 to 30 years of disease onset, cognitive decline continued, affecting global cognition and verbal memory. The baseline measures that best predicted CI were education, disease severity, lesion burden, and hippocampus and anterior cingulate cortex volume. (4) Conclusions: In MS, cognition deteriorates 5 years after disease onset, declining steadily over the next 25 years and more markedly affecting verbal memory. Education, disease severity, lesion burden, and volume of limbic structures predict future CI and may be helpful when identifying at-risk patients., The author(s) disclose receipt of the following financial support for the research, authorship, and/or publication of this article. This work was funded by: a Proyecto de Investigación en Salud (PI15/00587 to S.LL., and A.S.; PI15/00061 to P.V.; PI18/01030 to S.LL. and A.S.; and JR16/00006; MV17/00021; PI17/01228; RD16/0015/0003 to E.H.M-L.), integrated into the Plan Estatal de Investigación Científica y Técnica de Innovación I+D+I, and co-funded by the Instituto de Salud Carlos III-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER, “Otra manera de hacer Europa”); by the Red Española de Esclerosis Múltiple (REEM: RD16/0015/0002, RD16/0015/0003, RD12/0032/0002, RD12/0060/01-02); by TEVA Spain, the Ayudas Merck de Investigación 2017 from the Fundación Merck Salud and the Proyecto Societat Catalana Neurologia 2017; and by the MS Innovation GMSI, 2016 to E.H.M.-L., E.L.-S. holds a predoctoral grant from the University of Barcelona (APIF). M.A. holds equities in Bionure and Goodgut. C.M. was awarded by the Hospital Clinic Emili Letang, and she holds a P-FIS contract (FI19/00111). J.R. holds a Miguel Servet Research Contract (CPII19/00009) and Research Project PI19/00394 from the Plan Nacional de I+D+I 2013–2016, the Instituto de Salud Carlos III-Subdirección General de Evaluación y Fomento de la Investigación and the European Regional Development Fund (FEDER, ‘Investing in your future’). None of the funding bodies had any role in the design and performance of the study; the collection, management, analysis, and interpretation of the data; the preparation, revision, or approval of the manuscript; and the decision to submit the manuscript for publication., Peer Reviewed, Postprint (published version)
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- 2021
16. Incidence and Impact of COVID-19 in MS
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Sepúlveda, Maria, primary, Llufriu, Sara, additional, Martínez-Hernández, Eugenia, additional, Català, Martí, additional, Artola, Montse, additional, Hernando, Ana, additional, Montejo, Carmen, additional, Pulido-Valdeolivas, Irene, additional, Martínez-Heras, Eloy, additional, Guasp, Mar, additional, Solana, Elisabeth, additional, Llansó, Laura, additional, Escudero, Domingo, additional, Aldea, Marta, additional, Prats, Clara, additional, Graus, Francesc, additional, Blanco, Yolanda, additional, and Saiz, Albert, additional
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- 2021
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17. Cortical fractal dimension predicts disability worsening in Multiple Sclerosis patients
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Roura, Eloy, primary, Maclair, Grégory, additional, Andorrà, Magí, additional, Juanals, Ferran, additional, Pulido-Valdeolivas, Irene, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, Sepulveda, Maria, additional, Llufriu, Sara, additional, Martínez-Heras, Eloy, additional, Solana, Elisabeth, additional, Martinez-Lapiscina, Elena H, additional, and Villoslada, Pablo, additional
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- 2021
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18. Impact of Cognitive Reserve and Structural Connectivity on Cognitive Performance in Multiple Sclerosis
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Lopez-Soley, Elisabet, primary, Solana, Elisabeth, additional, Martínez-Heras, Eloy, additional, Andorra, Magi, additional, Radua, Joaquim, additional, Prats-Uribe, Albert, additional, Montejo, Carmen, additional, Sola-Valls, Nuria, additional, Sepulveda, Maria, additional, Pulido-Valdeolivas, Irene, additional, Blanco, Yolanda, additional, Martinez-Lapiscina, Elena H., additional, Saiz, Albert, additional, and Llufriu, Sara, additional
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- 2020
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19. Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI
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Martínez-Heras, Eloy, primary, Solana, Elisabeth, additional, Prados, Ferran, additional, Andorrà, Magí, additional, Solanes, Aleix, additional, López-Soley, Elisabet, additional, Montejo, Carmen, additional, Pulido-Valdeolivas, Irene, additional, Alba-Arbalat, Salut, additional, Sola-Valls, Nuria, additional, Sepúlveda, Maria, additional, Blanco, Yolanda, additional, Saiz, Albert, additional, Radua, Joaquim, additional, and Llufriu, Sara, additional
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- 2020
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20. Modified connectivity of vulnerable brain nodes in multiple sclerosis, their impact on cognition and their discriminative value
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Solana, Elisabeth, primary, Martinez-Heras, Eloy, additional, Casas-Roma, Jordi, additional, Calvet, Laura, additional, Lopez-Soley, Elisabet, additional, Sepulveda, Maria, additional, Sola-Valls, Nuria, additional, Montejo, Carmen, additional, Blanco, Yolanda, additional, Pulido-Valdeolivas, Irene, additional, Andorra, Magi, additional, Saiz, Albert, additional, Prados, Ferran, additional, and Llufriu, Sara, additional
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- 2019
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21. Muscle imaging in laminopathies: Synthesis study identifies meaningful muscles for follow-up
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GóMez-Andrés, David, Diaz-Manera, Jordi, Alejaldre, Aida, Pulido-Valdeolivas, Irene, GonzáLez-mera, Laura, Olivé, Montse, José Vilchez, Juan, De Munain, Adolfo LóPez, Paradas, Carmen, Muelas, Nuria, SáNchez-MontáÑez, Ángel, Alonso-Jimenez, Alicia, De la banda, Marta Gómez García, Dabaj, Ivana, Bonne, Gisèle, Munell, Francina, Carlier, Robert, Quijano-Roy, Susana, Vall d'Hebron University Hospital [Barcelona], CIBER de Enfermedades Raras (CIBERER), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), Hospital Universitario Virgen del Rocío [Sevilla], Hôpital Raymond Poincaré [AP-HP], Institut de Myologie, Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Sorbonne Université (SU), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Gestionnaire, Hal Sorbonne Université, and Centre de Recherche en Myologie
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Adult ,Male ,Distròfia muscular ,LMNA, machine learning, magnetic resonance ,Adolescent ,[SDV]Life Sciences [q-bio] ,LMNA ,laminopathy ,Statistics, Nonparametric ,Cohort Studies ,Muscular Atrophy, Spinal ,magnetic resonance ,Young Adult ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Child ,Muscle, Skeletal ,Aged ,imaging ,Extremities ,Middle Aged ,Muscular dystrophy ,Magnetic Resonance Imaging ,[SDV] Life Sciences [q-bio] ,Diagnòstic per la imatge ,machine learning ,Disease Progression ,Diagnostic imaging ,biomarker ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Tomography, X-Ray Computed - Abstract
International audience; INTRODUCTION:Particular fibroadipose infiltration patterns have been recently described by muscle imaging in congenital and later onset forms of LMNA-related muscular dystrophies (LMNA-RD).METHODS:Scores for fibroadipose infiltration of 23 lower limb muscles in 34 patients with LMNA-RD were collected from heat maps of 2 previous studies. Scoring systems were homogenized. Relationships between muscle infiltration and disease duration and age of onset were modeled with random forests.RESULTS:The pattern of infiltration differs according to disease duration but not to age of disease onset. The muscles whose progression best predicts disease duration were semitendinosus, biceps femoris long head, gluteus medius, and semimembranosus.DISCUSSION:In LMNA-RD, our synthetic analysis of lower limb muscle infiltration did not find major differences between forms with different ages of onset but allowed the identification of muscles with characteristic infiltration during disease progression. Monitoring of these specific muscles by quantitative MRI may provide useful imaging biomarkers in LMNA-RD. Muscle Nerve 58:812-817, 2018.
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- 2018
22. Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation
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Fundación Ramón Areces, Instituto de Salud Carlos III, Bionure, Villoslada, Pablo, Vila, Gemma, Colafrancesco, Valeria, Moreno, Beatriz, Fernández-Diez, Begoña, Vazquez, R, Pertsovskaya, Inna, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Messeguer, Joaquim, Vendrell-Navarro, Gloria, Frade López, José María, López-Sánchez, Noelia, Teixidó, Meritxell, Giralt, Ernest, Masso, Mar, Dugas, Jason C., Leonoudakis, Dmitri, Lariosa-Willingham, Karen D., Steinman, Lawrence, Messeguer, Àngel, Fundación Ramón Areces, Instituto de Salud Carlos III, Bionure, Villoslada, Pablo, Vila, Gemma, Colafrancesco, Valeria, Moreno, Beatriz, Fernández-Diez, Begoña, Vazquez, R, Pertsovskaya, Inna, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Messeguer, Joaquim, Vendrell-Navarro, Gloria, Frade López, José María, López-Sánchez, Noelia, Teixidó, Meritxell, Giralt, Ernest, Masso, Mar, Dugas, Jason C., Leonoudakis, Dmitri, Lariosa-Willingham, Karen D., Steinman, Lawrence, and Messeguer, Àngel
- Abstract
The development of neuroprotective therapies is a sought-after goal. By screening combinatorial chemical libraries using in vitro assays, we identified the small molecule BN201 that promotes the survival of cultured neural cells when subjected to oxidative stress or when deprived of trophic factors. Moreover, BN201 promotes neuronal differentiation, the differentiation of precursor cells to mature oligodendrocytes in vitro, and the myelination of new axons. BN201 modulates several kinases participating in the insulin growth factor 1 pathway including serum-glucocorticoid kinase and midkine, inducing the phosphorylation of NDRG1 and the translocation of the transcription factor Foxo3 to the cytoplasm. In vivo, BN201 prevents axonal and neuronal loss, and it promotes remyelination in models of multiple sclerosis, chemically induced demyelination, and glaucoma. In summary, we provide a new promising strategy to promote neuroaxonal survival and remyelination, potentially preventing disability in brain diseases.
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- 2019
23. Gait phenotypes in paediatric hereditary spastic paraplegia revealed by dynamic time warping analysis and random forests
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Pulido-Valdeolivas, Irene, Gómez-Andrés, David, Martín-Gonzalo, Juan Andrés, Rodríguez-Andonaegui, Irene, López-López, Javier, Pascual-Pascual, Samuel Ignacio, Rausell, Estrella, Universitat Autònoma de Barcelona, UAM. Departamento de Anatomía, Histología y Neurociencia, UAM. Departamento de Pediatría, and Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
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Pelvic tilt ,Male ,Kinematics ,Knee Joint ,Physiology ,Knees ,lcsh:Medicine ,Walking ,Pediatrics ,Corpus Callosum ,0302 clinical medicine ,Medicine and Health Sciences ,Cluster Analysis ,Public and Occupational Health ,Range of Motion, Articular ,Child ,lcsh:Science ,Musculoskeletal System ,Gait ,Neurologic Examination ,Multidisciplinary ,Physics ,Child Health ,Classical Mechanics ,Brain ,Biomechanical Phenomena ,Phenotypes ,medicine.anatomical_structure ,Child, Preschool ,Physical Sciences ,Legs ,Female ,Anatomy ,Gait Analysis ,Research Article ,musculoskeletal diseases ,Dynamic time warping ,medicine.medical_specialty ,Adolescent ,Hereditary spastic paraplegia ,Medicina ,Sensitivity and Specificity ,Pelvis ,Hereditary Spastic Paraplegias (HSP) ,03 medical and health sciences ,Physical medicine and rehabilitation ,Gait analysis (IGA) ,medicine ,Humans ,Hip ,business.industry ,Biological Locomotion ,Spastic Paraplegia, Hereditary ,Limbs (Anatomy) ,lcsh:R ,Ankles ,Biology and Life Sciences ,030229 sport sciences ,Random forests ,medicine.disease ,Sagittal plane ,Preferred walking speed ,Gait analysis ,lcsh:Q ,Ankle ,business ,human activities ,030217 neurology & neurosurgery - Abstract
The Hereditary Spastic Paraplegias (HSP) are a group of heterogeneous disorders with a wide spectrum of underlying neural pathology, and hence HSP patients express a variety of gait abnormalities. Classification of these phenotypes May help in monitoring disease progression and personalizing therapies. This is currently managed by measuring values of some kinematic and spatio-temporal parameters at certain moments during the gait cycle, either in the doctor´s surgery room or after very precise measurements produced by instrumental gait analysis (IGA). These methods, however, do not provide information about the whole structure of the gait cycle. Classification of the similarities among time series of IGA measured values of sagittal joint positions throughout the whole gait cycle can be achieved by hierarchical clustering analysis based on multivariate dynamic time warping (DTW). Random forests can estimate which are the most important isolated parameters to predict the classification revealed by DTW, since clinicians need to refer to them in their daily practice. We acquired time series of pelvic, hip, knee, ankle and forefoot sagittal angular positions from 26 HSP and 33 healthy children with an optokinetic IGA system. DTW revealed six gait patterns with different degrees of impairment of walking speed, cadence and gait cycle distribution and related with patient’s age, sex, GMFCS stage, concurrence of polyneuropathy and abnormal visual evoked potentials or corpus callosum. The most important parameters to differentiate patterns were mean pelvic tilt and hip flexion at initial contact. Longer time of support, decreased values of hip extension and increased knee flexion at initial contact can differentiate the mildest, near to normal HSP gait phenotype and the normal healthy one. Increased values of knee flexion at initial contact and delayed peak of knee flexion are important factors to distinguish GMFCS stages I from II- III and concurrence of polyneuropathy, DGA was in receipt of a grant from Sociedad Española de Neurología Pediátrica (SENEP). Publication fee was supported by EUF-ONCE-UAM and Asociación Española de Paraparesia Espástica Familiar (AEPEF).
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- 2018
24. Permutation Entropy and Irreversibility in Gait Kinematic Time Series from Patients with Mild Cognitive Decline and Early Alzheimer’s Dementia
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Martín-Gonzalo, Juan-Andrés, primary, Pulido-Valdeolivas, Irene, additional, Wang, Yu, additional, Wang, Ting, additional, Chiclana-Actis, Guadalupe, additional, Algarra-Lucas, Maria del Carmen, additional, Palmí-Cortés, Itziar, additional, Travieso, Jorge Fernández, additional, Torrecillas-Narváez, Maria Dolores, additional, Miralles-Martinez, Ambrosio A., additional, Rausell, Estrella, additional, Gómez-Andrés, David, additional, and Zanin, Massimiliano, additional
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- 2019
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25. Predictors of vision impairment in Multiple Sclerosis
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Sanchez-Dalmau, Bernardo, primary, Martinez-Lapiscina, Elena H., additional, Pulido-Valdeolivas, Irene, additional, Zubizarreta, Irati, additional, Llufriu, Sara, additional, Blanco, Yolanda, additional, Sola-Valls, Nuria, additional, Sepulveda, Maria, additional, Guerrero, Ana, additional, Alba, Salut, additional, Andorra, Magi, additional, Camos, Anna, additional, Sanchez-Vela, Laura, additional, Alfonso, Veronica, additional, Saiz, Albert, additional, and Villoslada, Pablo, additional
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- 2018
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26. Gait phenotypes in paediatric hereditary spastic paraplegia revealed by dynamic time warping analysis and random forests
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Pulido-Valdeolivas, Irene, primary, Gómez-Andrés, David, additional, Martín-Gonzalo, Juan Andrés, additional, Rodríguez-Andonaegui, Irene, additional, López-López, Javier, additional, Pascual-Pascual, Samuel Ignacio, additional, and Rausell, Estrella, additional
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- 2018
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27. Characterizing Normal and Pathological Gait through Permutation Entropy
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Zanin, Massimiliano, primary, Gómez-Andrés, David, additional, Pulido-Valdeolivas, Irene, additional, Martín-Gonzalo, Juan, additional, López-López, Javier, additional, Pascual-Pascual, Samuel, additional, and Rausell, Estrella, additional
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- 2018
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28. Magnetic resonance markers of tissue damage related to connectivity disruption in multiple sclerosis
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Solana, Elisabeth, primary, Martinez-Heras, Eloy, additional, Martinez-Lapiscina, Elena H., additional, Sepulveda, Maria, additional, Sola-Valls, Nuria, additional, Bargalló, Nuria, additional, Berenguer, Joan, additional, Blanco, Yolanda, additional, Andorra, Magi, additional, Pulido-Valdeolivas, Irene, additional, Zubizarreta, Irati, additional, Saiz, Albert, additional, and Llufriu, Sara, additional
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- 2018
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29. Combined walking outcome measures identify clinically meaningful response to prolonged-release fampridine
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Sola-Valls, Núria, primary, Blanco, Yolanda, additional, Sepúlveda, María, additional, Llufriu, Sara, additional, Martínez-Lapiscina, Elena H., additional, Zubizarreta, Irati, additional, Pulido-Valdeolivas, Irene, additional, Montejo, Carmen, additional, Villoslada, Pablo, additional, and Saiz, Albert, additional
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- 2018
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30. Dynamics and heterogeneity of brain damage in multiple sclerosis
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Kotelnikova, Ekaterina; https://orcid.org/0000-0002-8026-078X, Kiani, Narsis A, Abad, Elena, Martinez-Lapiscina, Elena H, Andorra, Magi, Zubizarreta, Irati; https://orcid.org/0000-0001-7637-7830, Pulido-Valdeolivas, Irene; https://orcid.org/0000-0003-0188-2458, Pertsovskaya, Inna; https://orcid.org/0000-0002-4873-8659, Alexopoulos, Leonidas G; https://orcid.org/0000-0003-0425-166X, Olsson, Tomas, Martin, Roland; https://orcid.org/0000-0002-0982-1329, Paul, Friedemann, Tegnér, Jesper, Garcia-Ojalvo, Jordi; https://orcid.org/0000-0002-3716-7520, Villoslada, Pablo; https://orcid.org/0000-0002-8735-6119, Kotelnikova, Ekaterina; https://orcid.org/0000-0002-8026-078X, Kiani, Narsis A, Abad, Elena, Martinez-Lapiscina, Elena H, Andorra, Magi, Zubizarreta, Irati; https://orcid.org/0000-0001-7637-7830, Pulido-Valdeolivas, Irene; https://orcid.org/0000-0003-0188-2458, Pertsovskaya, Inna; https://orcid.org/0000-0002-4873-8659, Alexopoulos, Leonidas G; https://orcid.org/0000-0003-0425-166X, Olsson, Tomas, Martin, Roland; https://orcid.org/0000-0002-0982-1329, Paul, Friedemann, Tegnér, Jesper, Garcia-Ojalvo, Jordi; https://orcid.org/0000-0002-3716-7520, and Villoslada, Pablo; https://orcid.org/0000-0002-8735-6119
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- 2017
31. Additional file 1: Table S1. of Patterns of motor signs in spinocerebellar ataxia type 3 at the start of follow-up in a reference unit
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Pulido-Valdeolivas, Irene, GĂłmez-AndrĂŠs, David, Sanz-Gallego, Irene, Rausell, Estrella, and Arpa, Javier
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nervous system ,musculoskeletal, neural, and ocular physiology ,macromolecular substances - Abstract
Definition of severity levels of polyneuropathy. (DOCX 45Â kb)
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- 2016
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32. Dynamics and heterogeneity of brain damage in multiple sclerosis
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Kotelnikova, Ekaterina, primary, Kiani, Narsis A., additional, Abad, Elena, additional, Martinez-Lapiscina, Elena H., additional, Andorra, Magi, additional, Zubizarreta, Irati, additional, Pulido-Valdeolivas, Irene, additional, Pertsovskaya, Inna, additional, Alexopoulos, Leonidas G., additional, Olsson, Tomas, additional, Martin, Roland, additional, Paul, Friedemann, additional, Tegnér, Jesper, additional, Garcia-Ojalvo, Jordi, additional, and Villoslada, Pablo, additional
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- 2017
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33. Patterns of motor signs in spinocerebellar ataxia type 3 at the start of follow-up in a reference unit
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Pulido-Valdeolivas, Irene, primary, Gómez-Andrés, David, additional, Sanz-Gallego, Irene, additional, Rausell, Estrella, additional, and Arpa, Javier, additional
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- 2016
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34. Alteraciones hormonales y del sistema motor en el ratón adulto deficiente de desyodasa tipo 2: fenotipo del posible síndrome humano
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Bárez-López, Soledad, Bosch-García, Daniel, Gómez-Andrés, David, Pulido-Valdeolivas, Irene, Montero-Pedrazuela, Ana, Obregón, María Jesús, and Guadaño-Ferraz, Ana
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Trabajo presentado en el XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular, celebrado en Madrid (España) del 03 al 06 de septiembre de 2013.
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- 2013
35. In vivo proton magnetic resonance spectroscopy regional metabolic profiles: differences among hippocampal formation, prefrontal cortex and cerebellum in adult rats using a machine learning approach
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Guadaño-Ferraz, Ana, Fernández-Lamo, Iván, Pacheco-Torres, Jesús, Gómez-Andrés, David, Pulido-Valdeolivas, Irene, López-Larrubia, Pilar, and Montero-Pedrazuela, Ana
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nervous system - Abstract
Resumen del póster presentado al Neuroscience celebrado en Nueva Orleans (USA) del 13 al 17 de octubre de 2012., 1H-Magnetic resonance spectroscopy (1H-MRS) is a non-invasive technology that provides information about several metabolite levels among multiple brain regions. This technology is widely used in preclinical and neuroscience research and in diagnosis in neurological practice. Although CNS is highly heterogeneous, few studies have been focused on interregional differences in 1H-MRS metabolic profiles and fewer, if any, have used multivariate approaches. Our aim is the development of a methodology to compare 1H-MRS metabolic profiles in order to improve the 1H-MRS result interpretation. In vivo spectra were acquired with a 7T PharmaScan® System (voxel size 27 mm3 and PRESS sequence, TE=35 ms) and fitted with LCModel. To avoid variance in signals, metabolite levels were normalized to NAA (N-Acetyl Aspartate). Four ratios to NAA were obtained: NAA+NAAG (NAA+N-Acetyl Aspartyl Glutamate), Cr+PCr (total Creatine), GPC+PCh (total Choline) and Glx (Glutamate+Glutamine) in hippocampal formation, prefrontal cortex and cerebellum from adult Wistar rats, aged 80, 105 and 130 days (n=8 each condition). Linear discriminant analysis (LDA), random forests (RF) and supervised neural networks (SNN) were used to classify brain regions according to age and NAA ratios. Cohen¿s kappa and the area under the receiver operating characteristic curve (AUC) were respectively calculated to measure global performance of each approach and each region in particular. Confidence intervals were calculated by bootstrapping. To measure discriminating importance of each dependent variable, the correlations among them and linear discriminant functions in LDA and the mean decrease in accuracy in RF were used. LDA, RF and SNN were able to discriminate among regions (Table 1). LDA showed the best global fitting. Compared to the others, the cerebellum metabolic profile was the most different. Cr+PCr and Glx were important in separating cerebellum and hippocampal formation respectively. Age was not an important factor in the models. This study provides a valid methodology to explore 1H-MRS interregional metabolic profiles detecting significant regional differences that are important in 1H-MRS result interpretation. This fact should be considered in clinical context.
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- 2012
36. Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase
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Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Bárez-López, Soledad, Bosch-García, Daniel, Gómez-Andrés, David, Pulido-Valdeolivas, Irene, Montero-Pedrazuela, Ana, Obregón, María Jesús, Guadaño-Ferraz, Ana, Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Bárez-López, Soledad, Bosch-García, Daniel, Gómez-Andrés, David, Pulido-Valdeolivas, Irene, Montero-Pedrazuela, Ana, Obregón, María Jesús, and Guadaño-Ferraz, Ana
- Abstract
[Background]: Thyroid hormones have a key role in both the developing and adult central nervous system and skeletal muscle. The thyroid gland produces mainly thyroxine (T4) but the intracellular concentrations of 3,5,3′-triiodothyronine (T3; the transcriptionally active hormone) in the central nervous system and skeletal muscle are modulated by the activity of type 2 deiodinase (D2). To date no neurological syndrome has been associated with mutations in the DIO2 gene and previous studies in young and juvenile D2-knockout mice (D2KO) did not find gross neurological alterations, possibly due to compensatory mechanisms. [Aim]: This study aims to analyze the motor phenotype of 3-and-6-month-old D2KO mice to evaluate the role of D2 on the motor system at adult stages in which compensatory mechanisms could have failed. [Results]: Motor abilities were explored by validated tests. In the footprint test, D2KO showed an altered global gait pattern (mice walked slower, with shorter strides and with a hindlimb wider base of support than wild-type mice). No differences were detected in the balance beam test. However, a reduced latency to fall was found in the rotarod, coat-hanger and four limb hanging wire tests indicating impairment on coordination and prehensile reflex and a reduction of muscle strength. In histological analyses of cerebellum and skeletal muscle, D2KO mice did not present gross structural abnormalities. Thyroid hormones levels and deiodinases activities were also determined. In D2KO mice, despite euthyroid T3 and high T4 plasma levels, T3 levels were significantly reduced in cerebral cortex (48% reduction) and skeletal muscle (33% reduction), but not in the cerebellum where other deiodinase (type 1) is expressed. [Conclusions]: The motor alterations observed in D2KO mice indicate an important role for D2 in T3 availability to maintain motor function and muscle strength. Our results suggest a possible implication of D2 in motor disorders.
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- 2014
37. Abnormal Motor Phenotype at Adult Stages in Mice Lacking Type 2 Deiodinase
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Bárez-López, Soledad, primary, Bosch-García, Daniel, additional, Gómez-Andrés, David, additional, Pulido-Valdeolivas, Irene, additional, Montero-Pedrazuela, Ana, additional, Obregon, Maria Jesus, additional, and Guadaño-Ferraz, Ana, additional
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- 2014
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38. Incidence and Impact of COVID-19 in MS: A Survey From a Barcelona MS Unit.
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Sepúlveda M, Llufriu S, Martínez-Hernández E, Català M, Artola M, Hernando A, Montejo C, Pulido-Valdeolivas I, Martínez-Heras E, Guasp M, Solana E, Llansó L, Escudero D, Aldea M, Prats C, Graus F, Blanco Y, and Saiz A
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- Adult, Aged, Aged, 80 and over, Antirheumatic Agents adverse effects, Antirheumatic Agents therapeutic use, Cohort Studies, Comorbidity, Cross-Sectional Studies, Electronic Health Records, Female, Hospitalization, Humans, Incidence, Male, Middle Aged, Multiple Sclerosis therapy, Sex Factors, Spain epidemiology, Surveys and Questionnaires, Treatment Outcome, Young Adult, COVID-19 complications, COVID-19 epidemiology, Multiple Sclerosis complications, Multiple Sclerosis epidemiology
- Abstract
Objective: To investigate the incidence of coronavirus disease 2019 (COVID-19) in a single-center cohort of patients with MS and to explore the contribution of their comorbidities and therapies to the outcome., Methods: A cross-sectional mixed-method study was conducted involving an email-based, self-administered questionnaire sent on May 21, 2020, to 586 patients with MS followed at the MS Unit of Hospital Clinic, University of Barcelona, along with telephone interview, and review of electronic medical records until June 18, 2020. The cumulative incidence of confirmed COVID-19 (positive PCR or antibody test) and all COVID-19 cases (confirmed and suspected) from the start of the pandemic was compared with the population estimates for Barcelona., Results: A total of 407 patients (69.5%) completed the survey. Most of the responders (67%) were female. The responders had a median age of 48 years (range 19-86), relapsing-remitting disease (84%), at least 1 comorbidity (45%), and were on disease-modifying therapy (DMT; 74.7%). COVID-19 was confirmed in 5 patients (1.2%) and suspected in 46 (11.3%). The cumulative incidence of confirmed COVID-19 cases was similar to that of the general population but was almost 2-fold higher when all cases were considered ( p < 0.001). Six patients (11.7%) were hospitalized, of which 5 had good recovery and 1 died. Hospitalized patients were more frequently male, had diabetes and had progressive forms of MS ( p < 0.05). DMT was not associated with the risk of infection or the outcome., Conclusions: In the studied MS cohort, the incidence of COVID-19 was higher than that of the general population; however, most patients did not require hospitalization and had a good outcome despite the frequent presence of comorbidities and treatment with DMT., (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)
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- 2021
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