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Your search keyword '"Pike, Mindy M."' showing total 11 results
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11 results on '"Pike, Mindy M."'

1. Abstract 18814: Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms

Author

Benson, Tyler W, Pike, Mindy M, Spuzzillo, Anthony, Hicks, Sarah, Pham, Michael, Bhandari, Rohan, Brunner, Seth, Wadding-Lee, Caris, Conrad, Kelsey, Russell, Hannah, Coughlin, Taylor, Aggarwal, Anu, Lyden, Sean, Mani, Kevin, Bjorck, Martin Gustaf, Wanhainen, Anders, Mix, Doran S, Lipworth, Loren, Robinson Cohen, Cassianne, Shim, Sharon, Edwards, Todd I, Tranter, Michael, Gardiner, Elizabeth, Mackman, Nigel, Cameron, Scott J, and Owens, A. Phillip

Published
2023
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3. Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms.

Author

Benson, Tyler W, Pike, Mindy M, Spuzzillo, Anthony, Hicks, Sarah M, Pham, Michael, Mix, Doran S, Brunner, Seth I, Wadding-Lee, Caris, Conrad, Kelsey A, Russell, Hannah M, Jennings, Courtney, Coughlin, Taylor M, Aggarwal, Anu, Lyden, Sean, Mani, Kevin, Björck, Martin, Wanhainen, Anders, Bhandari, Rohan, Lipworth-Elliot, Loren, Robinson-Cohen, Cassianne, Caputo, Francis J, Shim, Sharon, Edwards, Todd L, Tranter, Michael, Gardiner, Elizabeth E, Mackman, Nigel, Cameron, Scott J, Owens, A Phillip, Benson, Tyler W, Pike, Mindy M, Spuzzillo, Anthony, Hicks, Sarah M, Pham, Michael, Mix, Doran S, Brunner, Seth I, Wadding-Lee, Caris, Conrad, Kelsey A, Russell, Hannah M, Jennings, Courtney, Coughlin, Taylor M, Aggarwal, Anu, Lyden, Sean, Mani, Kevin, Björck, Martin, Wanhainen, Anders, Bhandari, Rohan, Lipworth-Elliot, Loren, Robinson-Cohen, Cassianne, Caputo, Francis J, Shim, Sharon, Edwards, Todd L, Tranter, Michael, Gardiner, Elizabeth E, Mackman, Nigel, Cameron, Scott J, and Owens, A Phillip

Abstract

UNLABELLED: A common feature in patients with abdominal aortic aneurysms (AAA) is the formation of a nonocclusive intraluminal thrombus (ILT) in regions of aortic dilation. Platelets are known to maintain hemostasis and propagate thrombosis through several redundant activation mechanisms, yet the role of platelet activation in the pathogenesis of AAA associated ILT is still poorly understood. Thus, we sought to investigate how platelet activation impacts the pathogenesis of AAA. Using RNA-sequencing, we identify that the platelet-associated transcripts are significantly enriched in the ILT compared to the adjacent aneurysm wall and healthy control aortas. We found that the platelet specific receptor glycoprotein VI (GPVI) is among the top enriched genes in AAA ILT and is increased on the platelet surface of AAA patients. Examination of a specific indicator of platelet activity, soluble GPVI (sGPVI), in two independent AAA patient cohorts is highly predictive of a AAA diagnosis and associates more strongly with aneurysm growth rate when compared to D-dimer in humans. Finally, intervention with the anti-GPVI antibody (J) in mice with established aneurysms blunted the progression of AAA in two independent mouse models. In conclusion, we show that levels of sGPVI in humans can predict a diagnosis of AAA and AAA growth rate, which may be critical in the identification of high-risk patients. We also identify GPVI as a novel platelet-specific AAA therapeutic target, with minimal risk of adverse bleeding complications, where none currently exist. KEY POINTS: Soluble glycoprotein VI, which is a platelet-derived blood biomarker, predicts a diagnosis of AAA, with high sensitivity and specificity in distinguishing patients with fast from slow-growing AAA.Blockade of glycoprotein VI in mice with established aneurysms reduces AAA progression and mortality, indicating therapeutic potential.

Published
2023
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6. Association of Genetically Predicted Fibroblast Growth Factor-23 with Heart Failure

Author

Akwo, Elvis, primary, Pike, Mindy M., additional, Ertuglu, Lale A., additional, Vartanian, Nicholas, additional, Farber-Eger, Eric, additional, Lipworth, Loren, additional, Perwad, Farzana, additional, Siew, Edward, additional, Hung, Adriana, additional, Bansal, Nisha, additional, de Boer, Ian, additional, Kestenbaum, Bryan, additional, Cox, Nancy J., additional, Ikizler, T. Alp, additional, Wells, Quinn, additional, and Robinson-Cohen, Cassianne, additional

Published
2022
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7. Effects of caloric restriction and aerobic exercise on circulating cell-free mitochondrial DNA in patients with moderate to severe chronic kidney disease

Author

Jaramillo-Morales, Javier, primary, Korucu, Berfu, additional, Pike, Mindy M., additional, Lipworth, Loren, additional, Stewart, Thomas, additional, Headley, Samuel A. E., additional, Germain, Michael, additional, Begue, Gwenaelle, additional, Roshanravan, Baback, additional, Tuttle, Katherine R., additional, Himmelfarb, Jonathan, additional, Robinson-Cohen, Cassianne, additional, Ikizler, T. Alp, additional, and Gamboa, Jorge L., additional

Published
2022
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8. The Authors Reply

Author

Pike, Mindy M., primary, Alsouqi, Aseel, additional, Headley, Samuel A.E., additional, Tuttle, Katherine, additional, Evans, Elizabeth Elspeth, additional, Milch, Charles M., additional, Moody, Kelsey Anne, additional, Germain, Michael, additional, Stewart, Thomas G., additional, Lipworth, Loren, additional, Himmelfarb, Jonathan, additional, Ikizler, T. Alp, additional, and Robinson-Cohen, Cassianne, additional

Published
2020
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9. Effects of caloric restriction and aerobic exercise on circulating cell-free mitochondrial DNA in patients with moderate to severe chronic kidney disease.

Author

Jaramillo-Morales, Javier, Korucu, Berfu, Pike, Mindy M., Lipworth, Loren, Stewart, Thomas, Headley, Samuel A. E., Germain, Michael, Begue, Gwenaelle, Roshanravan, Baback, Tuttle, Katherine R., Himmelfarb, Jonathan, Robinson-Cohen, Cassianne, Ikizler, T. Alp, and Gamboa, Jorge L.

Subjects
AEROBIC exercises, LOW-calorie diet, CHRONIC kidney failure, GLOMERULAR filtration rate, BODY mass index
Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) may induce systemic inflammation, a common condition in chronic kidney disease (CKD), by acting as a damage-associated molecular pattern. We hypothesized that in patients with moderate to severe CKD, aerobic exercise would reduce ccf-mtDNA levels. We performed a post hoc analysis of a multicenter randomized trial (NCT01150851) measuring plasma concentrations of ccf-mtDNA at baseline and 2 and 4 mo after aerobic exercise and caloric restriction. A total of 99 participants had baseline ccf-mtDNA, and 92 participants completed the study. The median age of the participants was 57 yr, 44% were female and 55% were male, 23% had diabetes, and 92% had hypertension. After adjusting for demographics, blood pressure, body mass index, diabetes, and estimated glomerular filtration rate, median ccf-mtDNA concentrations at baseline, 2 mo, and 4 mo were 3.62, 3.08, and 2.78 pM for the usual activity group and 2.01, 2.20, and 2.67 pM for the aerobic exercise group, respectively. A 16.1% greater increase per month in ccf-mtDNA was seen in aerobic exercise versus usual activity (P = 0.024), which was more pronounced with the combination of aerobic exercise and caloric restriction (29.5% greater increase per month). After 4 mo of intervention, ccf-mtDNA increased in the aerobic exercise group by 81.6% (95% confidence interval: 8.2-204.8, P = 0.024) compared with the usual activity group and was more marked in the aerobic exercise and caloric restriction group (181.7% increase, 95% confidence interval: 41.1-462.2, P = 0.003). There was no statistically significant correlation between markers of oxidative stress and inflammation with ccf-mtDNA. Our data indicate that aerobic exercise increased ccf-mtDNA levels in patients with moderate to severe CKD. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Effects of caloric restriction and aerobic exercise on circulating cell-free mitochondrial DNA in patients with moderate-to-severe chronic kidney disease

Author

Jaramillo-Morales, Javier, Korucu, Berfu, Pike, Mindy M, Lipworth, Loren, Stewart, Thomas G., Headley, Samuel AE, Germain, Michael, Begue, Gwenaelle, Roshanravan, Baback, Tuttle, Katherine R, Himmelfarb, Jonathan, Robinson-Cohen, Cassianne, Ikizler, T. Alp, and Gamboa, Jorge L

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) may induce systemic inflammation, a common condition chronic kidney disease (CKD), by acting as a damaged-associated molecular pattern. We hypothesized that in patients with moderate to severe CKD, aerobic exercise would reduce ccf-mtDNA levels. We performed a post hoc analysis of a multicenter randomized trial (NCT01150851), measuring plasma concentrations of ccf-mtDNA at baseline and two and four months after aerobic exercise and caloric restriction. A total of 99 participants had baseline ccf-mtDNA, and 92 completed the study. The median age was 57 years, 44% were female, 23% had diabetes, and 92% had hypertension. After adjusting for demographics, blood pressure, BMI, diabetes, and eGFR, median ccf-mtDNA concentrations at baseline, two, and four months were 3.62, 3.08, 2.78 picomolar for the usual activity group, and 2.01, 2.20, 2.67 picomolar for the aerobic exercise group, respectively. A 16.1% greater increase per month in ccf-mtDNA was seen in aerobic exercise versus usual activity (p = 0.024) that was more pronounced with the combination of aerobic exercise and caloric restriction (29.5% greater increase per month). After four months of intervention, ccf-mtDNA increased in the aerobic exercise group by 81.6% (95% confidence intervals [CI] 8.2-204.8; p = 0.024) compared to usual activity and was more marked in the aerobic exercise and caloric restriction group (181.7% increase, 95% CI 41.1-462.2; p = 0.003). There was no statistically significant correlation between markers of oxidative stress and inflammation with ccf-mtDNA. Our data indicate that aerobic exercise increased ccf-mtDNA levels in patients with moderate-to-severe CKD.

Published
2021
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