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1. Design, Synthesis, and Biological Evaluation of 6-Benzoxazole Benzimidazole Derivatives with Antihypertension Activities.

Author

Wu Z, Bao XL, Zhu WB, Wang YH, Phuong Anh NT, Wu XF, Yan YJ, and Chen ZL

Abstract

A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT 1 receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds 1b and 2b could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds 1b and 2b could be considered as potential antihypertension drug candidates., Competing Interests: The authors declare no competing financial interest.

Published
2018
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