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2. The Chaîne Opératoire Approach for Interpreting Personal Ornament Production: Marble Beads in Copper Age Tuscany (Italy)

Author

Vassanelli Alice, Petrinelli Pannocchia Cristiana, and Starnini Elisabetta

Subjects
chaîne opératoire, marble beads, copper age, tuscany, experimental archaeology, Archaeology, CC1-960
Abstract

This article discusses the chaîne opératoire concept in prehistoric archaeology, traditionally employed for the study of lithic industries and ceramic production, and focuses on personal ornament manufacture. This category of non-functional objects has been analysed with the operational sequence approach in the framework of a research project aimed at the techno-functional study of prehistoric marble artefacts. Throughout an experimental approach, the study presents the actions and choices made by the artisans to produce marble beads and tries to understand the role and social-cultural meaning that these items had for the Copper Age communities in Tuscany. Finally, our study proved that the beginning of the use of the Apuan marble can be traced back to the sixth millennium BC, and it was connected with the production of personal ornaments, reaching its peak during the Copper Age.

Published
2023
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10. Telomeric associations and chromosome instability in ataxia telangiectasia T cells characterized by TCL1 expression

Author

Petrinelli, P, Elli, R, Marcucci, L, Tabolacci, Elisabetta, Barbieri, C, Antonelli, A, E Tabolacci (ORCID:0000-0002-4707-2242), Petrinelli, P, Elli, R, Marcucci, L, Tabolacci, Elisabetta, Barbieri, C, Antonelli, A, and E Tabolacci (ORCID:0000-0002-4707-2242)

Abstract

T-cell tumors in ataxia telangiectasia (AT), such as T-PLL/T-CLL, are first preceded by the development of a large clone of T-lymphocytes, characterized by chromosomal rearrangements, which usually involve specific regions such as the 14q11 region. Malignancy develops years later, after additional chromosomal changes resulting from the genomic instability consequent to ATM disruption and to the activation of the TCL1 oncogene. Here we report the results of a cytogenetic follow-up of an AT patient (AT94-1), still without signs of hematological abnormalities, bearing a T-lymphocyte clone characterized by the t(14;14)(q11;q32) rearrangement and having TCL1 expression. We demonstrated that in clonal cells TCL1 expression correlates with increasing genomic instability and in time this mainly induces chromosomal rearrangements and telomeric associations (tas). Chromosome 21 is not randomly involved; in particular, an i(21q) indicates that it is a subclone prone to additional genetic changes and could represent an early chromosomal rearrangement involved in tumorigenesis. With regard to the increase in tas, we observed that: (i) it is inversely correlated with the proliferative ability of AT94-1 lymphocytes in PHA-stimulated short-term cultures (cell aging in vitro); (ii) this increase is not due to changes either in cell radiosensitivity (measured as bleomycin (BML)-sensitivity) or due to an illegitimate recombination (measured as adriamycin-sensitivity), which may not be sufficient for tumor development.

Published
2001

13. Establishment of a new Epstein-Barr virus-immortalized cell line from chronic lymphocytic leukemia with trisomy of chromosome 12 that produces monoclonal IgM against a sheep RBC antigen

Author

Crescenzi, M, Napolitano, M, Carbonari, M, Antonelli, A, Petrinelli, P, Gaetano, C, and Fiorilli, M

Abstract

Leukemia cells from a patient with chronic lymphocytic leukemia (CLL) were found to bind sheep RBC (SRBC) through their monoclonal surface IgM. A lymphoblastoid cell line was obtained by immortalization of leukemic cells with Epstein-Barr virus (EBV). Cultured leukemic cells were found to have a supernumerary chromosome 12, an abnormality typical of CLL of the B cell type. To our knowledge, this is the first EBV-immortalized cell line from B-CLL cells of known SRBC specificity and the third reported CLL cell line carrying trisomy of chromosome 12.

Published
1988
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14. VP16 hypersensitivity and increased faulty recombination in ataxia telangiectasia lymphocytes characterized by the tandem translocation t(14;14)(q11;q32).

Author

Petrinelli, P, Elli, R, Marcucci, L, Barbieri, C, Ambra, R, and Antonelli, A

Abstract

Ataxia telangiectasia (AT) patients show variable degrees of immunodeficiency and a higher than normal predisposition to lymphoid malignancies. AT cells are characterized by spontaneous chromosome instability resulting in chromosome breakage and in non random chromosome rearrangements. Sequential cytogenetic studies on T-lymphocytes from an AT patient showed the progressive development of a clone bearing a tandem translocation t(14;14)(q11;q32). The abnormal clone had spontaneous chromosome rearrangements. Compared to non clonal cells, the abnormal clone displayed a higher frequency of spontaneous chromosome rearrangements. In only the clonal cells we observed two particular and predominant rearrangements: isodicentric chromosomes and telomeric associations which may derive from faulty recombination. Chromosome instability induced by the etoposide VP16, a DNA topoisomerase II inhibitor, was evaluated in terms of chromosome breakage and SCE frequency. T-lymphocytes from the AT patient showed hypersensitivity to VP16 significantly higher than normal T-lymphocytes. The chromosome instability induced by VP16 is significantly higher in clonal than in non clonal cells, whilst the chromosome instability induced by the radiomimetic drug bleomycin is not significantly different in the two AT lymphocyte subpopulations. The different spontaneous chromosome instability in clonal and non clonal cells together with their different behavior after treatment with only VP16, suggest that clonal cells bearing the tandem translocation could have increased faulty recombination. Given the presence of translocations t(14;14)(q11;q32) in T-prolymphocytic leukemias and T-cell tumors of non AT patients, our findings suggest that VP16 could be considered an antineoplastic treatment particularly indicated in these patients.

Published
1996
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