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6 results on '"Peterson, Joseph J."'

2. A Pan-RNase Inhibitor Enabling CRISPR-mRNA Platforms for Engineering of Primary Human Monocytes

Author

Laoharawee, Kanut, primary, Johnson, Matthew J., additional, Lahr, Walker S., additional, Sipe, Christopher J., additional, Kleinboehl, Evan, additional, Peterson, Joseph J., additional, Lonetree, Cara-lin, additional, Bell, Jason B., additional, Slipek, Nicholas J., additional, Crane, Andrew T., additional, Webber, Beau R., additional, and Moriarity, Branden S., additional

Published
2022
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3. Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

Author

Smeester, Branden A., primary, Draper, Garrett M., additional, Slipek, Nicholas J., additional, Larsson, Alex T., additional, Stratton, Natalie, additional, Pomeroy, Emily J., additional, Becklin, Kelsie L., additional, Yamamoto, Kenta, additional, Williams, Kyle B., additional, Laoharawee, Kanut, additional, Peterson, Joseph J., additional, Abrahante, Juan E., additional, Rathe, Susan K., additional, Mills, Lauren J., additional, Crosby, Margaret R., additional, Hudson, Wendy A., additional, Rahrmann, Eric P., additional, Largaespada, David A., additional, and Moriarity, Branden S., additional

Published
2020
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4. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

Author

Smeester, Branden A., primary, Slipek, Nicholas J., additional, Pomeroy, Emily J., additional, Bomberger, Heather E., additional, Shamsan, Ghaidan A., additional, Peterson, Joseph J., additional, Crosby, Margaret R., additional, Draper, Garrett M., additional, Becklin, Kelsie L., additional, Rahrmann, Eric P., additional, McCarthy, James B., additional, Odde, David J., additional, Wood, David K., additional, Largaespada, David A., additional, and Moriarity, Branden S., additional

Published
2019
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5. Surface-grafted conjugated polymers for hybrid cellulose materials

Author

Peterson, Joseph J., Willgert, Markus, Hansson, Susanne, Malmström, Eva, Carter, Kenneth R., Peterson, Joseph J., Willgert, Markus, Hansson, Susanne, Malmström, Eva, and Carter, Kenneth R.

Abstract

Not duplicate with DiVA 426449QC 20230202

Published
2011

6. Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders.

Author

Laoharawee K, Kleinboehl EW, Jensen JD, Peterson JJ, Slipek NJ, Wick BJ, Johnson MJ, Webber BR, and Moriarity BS

Abstract

Enzymopathy disorders are the result of missing or defective enzymes. Amongst these enzymopathies, mucopolysaccharidosis type I, is a rare genetic lysosomal storage disorder caused by mutations in the gene encoding alpha-L-iduronidase (IDUA), ultimately causes toxic build-up of glycosaminoglycans (GAGs). There is currently no cure and standard treatments provide insufficient relief to the skeletal structure and central nervous system (CNS). Human memory T cells (Tm) migrate throughout the body's tissues and can persist for years, making them an attractive approach for cellular-based, systemic enzyme replacement therapy. Here, we tested genetically engineered, IDUA-expressing Tm as a cellular therapy in an immunodeficient mouse model of MPS I. Our results demonstrate that a single dose of engineered Tm leads to detectable IDUA enzyme levels in the blood for up to 22 weeks and reduced urinary GAG excretion. Furthermore, engineered Tm take up residence in nearly all tested tissues, producing IDUA and leading to metabolic correction of GAG levels in the heart, lung, liver, spleen, kidney, bone marrow, and the CNS. Our study indicates that genetically engineered Tm holds great promise as a platform for cellular-based enzyme replacement therapy for the treatment of mucopolysaccharidosis type I and potentially many other enzymopathies and protein deficiencies.

Published
2024
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