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2,902 results on '"Petersen, J A"'

2. The history of the observatory library at {\O}stervold in Copenhagen, Denmark

Author

Dorch, S. B. F. and Petersen, J. O.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - History and Philosophy of Physics
Abstract

About fifty years after the work that astronomer Tycho Brahe carried out while living on the island of Hven had made him world famous, King Christian IV of Denmark built the Trinity Buildings in Copenhagen. The Tower observatory was opened in 1642, and it housed the astronomers from the University of Copenhagen until 1861 when a new, modern observatory was built at {\O}stervold in the eastern part of the city. In 1996, all the University astronomers from the observatories at {\O}stervold and the small town of Brorfelde were relocated to the Rockefeller Buildings at {\O}sterbro, and the two observatories were closed. In this paper we focus on the library at the observatory in {\O}stervold, and its subsequent fate following the close-down of that observatory., Comment: 13 pages, 17 figures

Published
2022

3. Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients

Author

Antoni, C., Teufel, A., Vogelmann, R., Ebert, M., Balavoine, J., Giostra, E., Berning, M., Hampe, J., Boettler, T., Neumann-Haefelin, C., Thimme, R., De Gottardi, A., Rauch, A., Semmo, N., Ellenrieder, V., Gress, M., Herrmann, A., Stallmach, A., Hoffmann, D., Protzer, U., Kodal, A., Löbermann, M., Götze, T., Keitel-Anselmino, V., Lange, C.M., Zachoval, R., Mayerle, J., Maieron, A., Michl, P., Merle, U., Moradpour, D., Chave, J.-P., Muche, M., Epple, H.-J., Müller-Schilling, M., Kocheise, F., Müller, T., Tacke, F., Roeb, E., Rissland, J., Krawczyk, M., Schulze, P., Semela, D., Spengler, U., Rockstroh, J., Strassburg, C.P., Siebler, J., Schulze zur Wiesch, J., Piecha, F., von Felden, J., Jordan, S., Lohse, A., Sprinzl, M., Galle, P., Stauber, R., Strey, B., Steckstor, W., Schmiegel, W., Brockmeyer, N.H., Canbay, A., Trautwein, C., Uschner, F., Trebicka, J., Weber, T., Wedemeyer, H., Cornberg, M., Manns, M., Wietzke-Braun, P., Günther, R., Willuweit, K., Hilgard, G., Schmidt, H., Zizer, E., Backhus, J., Seufferlein, T., Al-Taie, O., Angeli, W., Beckebaum, S., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Haag, S., Heinzow, H., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reinhardt, L., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Wege, H., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Buggisch, P., Matschenz, K., Petersen, J., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Tal, A.O., Schneider, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, J., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Hartmann, C., Klag, C., Härter, G., Herder, M., Heuchel, T., Heuer, S., Hinrichsen, H., Seegers, B., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Wolfratshausen, Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Gute, P., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mauss, S., Mayer, C., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., K, Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, W., Schmidt-Heinevetter, G., Fabris, J. Schmidtler-von, Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Graf, Christiana, Berg, Christoph P., Port, Kerstin, Deterding, Katja, Buggisch, Peter, Peiffer, Kai-Henrik, Vermehren, Johannes, Dultz, Georg, Geier, Andreas, Reiter, Florian P., Bruns, Tony, Schattenberg, Jörn M., Durmashkina, Elena, Gustot, Thierry, Moreno, Christophe, Trauth, Janina, Discher, Thomas, Fischer, Janett, Berg, Thomas, Kremer, Andreas E., Müllhaupt, Beat, Zeuzem, Stefan, and Sarrazin, Christoph

Published
2024
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5. PANDA Phase One

Author

Barucca, G., Davì, F., Lancioni, G., Mengucci, P., Montalto, L., Natali, P. P., Paone, N., Rinaldi, D., Scalise, L., Krusche, B., Steinacher, M., Liu, Z., Liu, C., Liu, B., Shen, X., Sun, S., Zhao, G., Zhao, J., Albrecht, M., Alkakhi, W., Bökelmann, S., Coen, S., Feldbauer, F., Fink, M., Frech, J., Freudenreich, V., Fritsch, M., Grochowski, J., Hagdorn, R., Heinsius, F. H., Held, T., Holtmann, T., Keshk, I., Koch, H., Kopf, B., Kümmel, M., Küßner, M., Li, J., Linzen, L., Maldaner, S., Oppotsch, J., Pankonin, S., Pelizäus, M., Pflüger, S., Reher, J., Reicherz, G., Schnier, C., Steinke, M., Triffterer, T., Wenzel, C., Wiedner, U., Denizli, H., Er, N., Keskin, U., Yerlikaya, S., Yilmaz, A., Beck, R., Chauhan, V., Hammann, C., Hartmann, J., Ketzer, B., Müllers, J., Salisbury, B., Schmidt, C., Thoma, U., Urban, M., Bianconi, A., Bragadireanu, M., Pantea, D., Rimjaem, S., Domagala, M., Filo, G., Lisowski, E., Lisowski, F., Michałek, M., Poznański, P., Płażek, J., Korcyl, K., Lebiedowicz, P., Pysz, K., Schäfer, W., Szczurek, A., Firlej, M., Fiutowski, T., Idzik, M., Moron, J., Swientek, K., Terlecki, P., Korcyl, G., Lalik, R., Malige, A., Moskal, P., Nowakowski, K., Przygoda, W., Rathod, N., Salabura, P., Smyrski, J., Augustin, I., Böhm, R., Lehmann, I., Schmitt, L., Varentsov, V., Al-Turany, M., Belias, A., Deppe, H., Dzhygadlo, R., Flemming, H., Gerhardt, A., Götzen, K., Heinz, A., Jiang, P., Karabowicz, R., Koch, S., Kurilla, U., Lehmann, D., Lühning, J., Lynen, U., Orth, H., Peters, K., Ritman, J., Schepers, G., Schmidt, C. J., Schwarz, C., Schwiening, J., Täschner, A., Traxler, M., Voss, B., Wieczorek, P., Abazov, V., Alexeev, G., Barabanov, M. Yu., Dodokhov, V. Kh., Efremov, A., Fechtchenko, A., Galoyan, A., Golovanov, G., Koshurnikov, E. K., Lobanov, Y. Yu., Olshevskiy, A. G., Piskun, A. A., Samartsev, A., Shimanski, S., Skachkov, N. B., Skachkova, A. N., Strokovsky, E. A., Tokmenin, V., Uzhinsky, V., Verkheev, A., Vodopianov, A., Zhuravlev, N. I., Watts, D., Böhm, M., Eyrich, W., Lehmann, A., Miehling, D., Pfaffinger, M., Seth, K., Xiao, T., Ali, A., Hamdi, A., Himmelreich, M., Krebs, M., Nakhoul, S., Nerling, F., Gianotti, P., Lucherini, V., Bracco, G., Bodenschatz, S., Brinkmann, K. T., Brück, L., Diehl, S., Dormenev, V., Düren, M., Erlen, T., Hahn, C., Hayrapetyan, A., Hofmann, J., Kegel, S., Khalid, F., Köseoglu, I., Kripko, A., Kühn, W., Metag, V., Moritz, M., Nanova, M., Novotny, R., Orsich, P., Pereira-de-Lira, J., Sachs, M., Schmidt, M., Schubert, R., Strickert, M., Wasem, T., Zaunick, H. G., Tomasi-Gustafsson, E., Glazier, D., Ireland, D., Seitz, B., Kappert, R., Kavatsyuk, M., Loehner, H., Messchendorp, J., Rodin, V., Kalita, K., Huang, G., Liu, D., Peng, H., Qi, H., Sun, Y., Zhou, X., Kunze, M., Azizi, K., Olgun, A. T., Tavukoglu, Z., Derichs, A., Dosdall, R., Esmail, W., Gillitzer, A., Goldenbaum, F., Grunwald, D., Jokhovets, L., Kannika, J., Kulessa, P., Orfanitski, S., Perez-Andrade, G., Prasuhn, D., Prencipe, E., Pütz, J., Rosenthal, E., Schadmand, S., Schmitz, R., Scholl, A., Sefzick, T., Serdyuk, V., Stockmanns, T., Veretennikov, D., Wintz, P., Wüstner, P., Xu, H., Zhou, Y., Cao, X., Hu, Q., Liang, Y., Rigato, V., Isaksson, L., Achenbach, P., Corell, O., Denig, A., Distler, M., Hoek, M., Lauth, W., Leithoff, H. H., Merkel, H., Müller, U., Petersen, J., Pochodzalla, J., Schlimme, S., Sfienti, C., Thiel, M., Bleser, S., Bölting, M., Capozza, L., Dbeyssi, A., Ehret, A., Klasen, R., Kliemt, R., Maas, F., Motzko, C., Noll, O., Piñeiro, D. Rodríguez, Schupp, F., Steinen, M., Wolff, S., Zimmermann, I., Kazlou, D., Korzhik, M., Missevitch, O., Balanutsa, P., Chernetsky, V., Demekhin, A., Dolgolenko, A., Fedorets, P., Gerasimov, A., Golubev, A., Kantsyrev, A., Kirin, D. Y., Kristi, N., Ladygina, E., Luschevskaya, E., Matveev, V. A., Panjushkin, V., Stavinskiy, A. V., Balashoff, A., Boukharov, A., Bukharova, M., Malyshev, O., Vishnevsky, E., Bonaventura, D., Brand, P., Hetz, B., Hüsken, N., Kellers, J., Khoukaz, A., Klostermann, D., Mannweiler, C., Vestrick, S., Bumrungkoh, D., Herold, C., Khosonthongkee, K., Kobdaj, C., Limphirat, A., Manasatitpong, K., Nasawad, T., Pongampai, S., Simantathammakul, T., Srisawad, P., Wongprachanukul, N., Yan, Y., Yu, C., Zhang, X., Zhu, W., Antokhin, E., Barnyakov, A. Yu., Beloborodov, K., Blinov, V. E., Kuyanov, I. A., Pivovarov, S., Pyata, E., Tikhonov, Y., Blinov, A. E., Kononov, S., Kravchenko, E. A., Lattery, M., Boca, G., Duda, D., Finger, M., Finger, Jr., M., Kveton, A., Prochazka, I., Slunecka, M., Volf, M., Jary, V., Korchak, O., Marcisovsky, M., Neue, G., Novy, J., Tomasek, L., Tomasek, M., Virius, M., Vrba, V., Abramov, V., Bukreeva, S., Chernichenko, S., Derevschikov, A., Ferapontov, V., Goncharenko, Y., Levin, A., Maslova, E., Melnik, Y., Meschanin, A., Minaev, N., Mochalov, V., Moiseev, V., Morozov, D., Nogach, L., Poslavskiy, S., Ryazantsev, A., Ryzhikov, S., Semenov, P., Shein, I., Uzunian, A., Vasiliev, A., Yakutin, A., Belostotski, S., Fedotov, G., Izotov, A., Manaenkov, S., Miklukho, O., Cederwall, B., Preston, M., Tegner, P. E., Wölbing, D., Gandhi, K., Rai, A. K., Godre, S., Crede, V., Dobbs, S., Eugenio, P., Bussa, M. P., Spataro, S., Calvo, D., De Remigis, P., Filippi, A., Mazza, G., Wheadon, R., Iazzi, F., Lavagno, A., Akram, A., Calen, H., Andersson, W. Ikegami, Johansson, T., Kupsc, A., Marciniewski, P., Papenbrock, M., Regina, J., Rieger, J., Schönning, K., Wolke, M., Chlopik, A., Kesik, G., Melnychuk, D., Tarasiuk, J., Wojciechowski, M., Wronka, S., Zwieglinski, B., Amsler, C., Bühler, P., Marton, J., Zimmermann, S., Fischer, C. S., Haidenbauer, J., Hanhart, C., Lutz, M. F. M., and Ryan, Sinéad M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany, provides unique possibilities for a new generation of hadron-, nuclear- and atomic physics experiments. The future antiProton ANnihilations at DArmstadt (PANDA or $\overline{\rm P}$ANDA) experiment at FAIR will offer a broad physics programme, covering different aspects of the strong interaction. Understanding the latter in the non-perturbative regime remains one of the greatest challenges in contemporary physics. The antiproton-nucleon interaction studied with PANDA provides crucial tests in this area. Furthermore, the high-intensity, low-energy domain of PANDA allows for searches for physics beyond the Standard Model, e.g. through high precision symmetry tests. This paper takes into account a staged approach for the detector setup and for the delivered luminosity from the accelerator. The available detector setup at the time of the delivery of the first antiproton beams in the HESR storage ring is referred to as the \textit{Phase One} setup. The physics programme that is achievable during Phase One is outlined in this paper., Comment: 35 pages, 15 figures

Published
2021
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7. Predicting Short-Term Mortality in Older Patients Discharged from Acute Hospitalizations Lasting Less Than 24 Hours

Author

Heltø ALK, Rosager EV, Aasbrenn M, Maule CF, Petersen J, Nielsen FE, Suetta C, and Gregersen R

Subjects
machine-learning, prediction model, register-based, geriatric, emergency medicine, early discharge, Infectious and parasitic diseases, RC109-216
Abstract

Amalia Lærke Kjær Heltø,1,2 Emilie Vangsgaard Rosager,1,2 Martin Aasbrenn,3 Cathrine Fox Maule,4 Janne Petersen,4,5 Finn Erland Nielsen,1 Charlotte Suetta,3 Rasmus Gregersen1,4,5 1Department of Emergency Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; 2Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 3Department of Geriatrics and Palliative Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; 4Center of Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; 5Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkCorrespondence: Amalia Lærke Kjær Heltø, Bispebjerg and Frederiksberg Hospital, Department of Emergency Medicine, Ebba Lunds Vej 40A, Building 67, 2. floor, Copenhagen, NV, 2400, Denmark, Tel +45 60654575, Email amalia.laerke.kjaer.heltoe.01@regionh.dkPurpose: Over coming decades, a rise in the number of short, acute hospitalizations of older people is to be expected. To help physicians identify high-risk patients prior to discharge, we aimed to develop a model capable of predicting the risk of 30-day mortality for older patients discharged from short, acute hospitalizations and to examine how model performance changed with an increasing amount of information.Methods: This registry-based study included acute hospitalizations in Denmark for 2016– 2018 lasting ≤ 24 hours where patients were permanent residents, ≥ 65 years old, and discharged alive. Utilizing many different predictor variables, we developed random forest models with an increasing amount of information, compared their performance, and examined important variables.Results: We included 107,132 patients with a median age of 75 years. Of these, 3.3% (n=3575) died within 30 days of discharge. Model performance improved especially with the addition of laboratory results and information on prior acute admissions (AUROC 0.835), and again with comorbidities and number of prescription drugs (AUROC 0.860). Model performance did not improve with the addition of sociodemographic variables (AUROC 0.861), apart from age and sex. Important variables included age, dementia, number of prescription drugs, C-reactive protein, and eGFR.Conclusion: The best model accurately estimated the risk of short-term mortality for older patients following short, acute hospitalizations. Trained on a large and heterogeneous dataset, the model is applicable to most acute clinical settings and could be a useful tool for physicians prior to discharge.Keywords: machine learning, prediction model, register-based, geriatric, emergency medicine, early discharge

Published
2023

8. Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease and Risk of Acquiring Streptococcus pneumoniae Infection. A Multiregional Epidemiological Study

Author

Heerfordt CK, Eklöf J, Sivapalan P, Ingebrigtsen TS, Biering-Sørensen T, Harboe ZB, Koefod Petersen J, Andersen CØ, Boel JB, Bock AK, Mathioudakis AG, Hurst JR, Kolekar S, Johansson SL, Bangsborg JM, Jarløv JO, Dessau RB, Laursen CB, Perch M, and Jensen JUS

Subjects
copd, inhaled corticosteroids, streptococcus pneumoniae, clinical epidemiology., Diseases of the respiratory system, RC705-779
Abstract

Christian Kjer Heerfordt,1 Josefin Eklöf,1 Pradeesh Sivapalan,1 Truls Sylvan Ingebrigtsen,1 Tor Biering-Sørensen,2– 4 Zitta Barrella Harboe,4,5 Jesper Koefod Petersen,6,7 Christian Østergaard Andersen,8 Jonas Bredtoft Boel,9 Anne Kathrine Bock,10 Alexander G Mathioudakis,11,12 John R Hurst,13 Shailesh Kolekar,7 Sofie Lock Johansson,14 Jette Marie Bangsborg,9 Jens Otto Jarløv,9 Ram Benny Dessau,15 Christian Borbjerg Laursen,14,16 Michael Perch,4,17 Jens-Ulrik Stæhr Jensen1,4,18 1Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, Denmark; 2Department of Cardiology, Herlev and Gentofte Hospital, Cardiovascular Non-Invasive Imaging Research Laboratory, University of Copenhagen, Copenhagen, Denmark; 3Faculty of Biomedical Sciences, Copenhagen University, Copenhagen, Denmark; 4Department of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 5Department of Respiratory Medicine and Infectious Diseases, Copenhagen University Hospital, North Zealand, Denmark; 6Department of Respiratory Medicine, Zealand University Hospital Naestved, Naestved, Denmark; 7Department of Pulmonary Medicine, Zealand University Hospital, Roskilde, Denmark; 8Department of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, Denmark; 9Department of Clinical Microbiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark; 10Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark; 11The North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; 12Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; 13UCL Respiratory, University College London, London, UK; 14Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark; 15Department of Clinical Microbiology, Zealand University Hospital, Slagelse Hospital, Slagelse, Denmark; 16Institute for Clinical Research, University of Southern Denmark, Odense, Denmark; 17Department of Cardiology, Section for Lung Transplantation, Rigshospitalet, Copenhagen, Denmark; 18PERSIMUNE & CHIP: Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkCorrespondence: Christian Kjer Heerfordt, Section of Respiratory Medicine, Department of Medicine, Copenhagen University Hospital Herlev and Gentofte Hospital, Hellerup, Denmark, Tel +4523303431, Email christian.kjer.heerfordt@regionh.dkBackground: Inhaled corticosteroids (ICS) are associated with an increased risk of clinical pneumonia among patients with chronic obstructive pulmonary disease (COPD). It is unknown whether the risk of microbiologically verified pneumonia such as pneumococcal pneumonia is increased in ICS users.Methods: The study population consists of all COPD patients followed in outpatient clinics in eastern Denmark during 2010– 2017. ICS use was categorized into four categories based on accumulated use. A Cox proportional hazard regression model was used adjusting for age, body mass index, sex, airflow limitation, use of oral corticosteroids, smoking, and year of cohort entry. A propensity score matched analysis was performed for sensitivity analyses.Findings: A total of 21,438 patients were included. Five hundred and eighty-two (2.6%) patients acquired a positive lower airway tract sample with S. pneumoniae during follow-up. In the multivariable analysis ICS-use was associated with a dose-dependent risk of S. pneumoniae as follows: low ICS dose: HR 1.11, 95% CI 0.84 to 1.45, p = 0.5; moderate ICS dose: HR 1.47, 95% CI 1.13 to 1.90, p = 0.004; high ICS dose: HR 1.77, 95% CI 1.38 to 2.29, p < 0.0001, compared to no ICS use. Sensitivity analyses confirmed these results.Interpretation: Use of ICS in patients with severe COPD was associated with an increased and dose-dependent risk of acquiring S. pneumoniae, but only for moderate and high dose. Caution should be taken when administering high dose of ICS to patients with COPD. Low dose of ICS seemed not to carry this risk.Keywords: COPD, inhaled corticosteroids, Streptococcus pneumoniae, clinical epidemiology

Published
2023

10. Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.

Author

Raudsepp, T, Finno, Carrie, Bellone, R, and Petersen, J

Subjects
Mendelian traits, Y chromosome, ancient genomes, centromeres, complex traits, domestication, modern breeds, signatures of selection, Animals, Centromere, Domestication, Genome, Horses, Male, Pedigree, Physical Conditioning, Animal, Polymorphism, Single Nucleotide, Population Dynamics, Y Chromosome
Abstract

The horse reference genome from the Thoroughbred mare Twilight has been available for a decade and, together with advances in genomics technologies, has led to unparalleled developments in equine genomics. At the core of this progress is the continuing improvement of the quality, contiguity and completeness of the reference genome, and its functional annotation. Recent achievements include the release of the next version of the reference genome (EquCab3.0) and generation of a reference sequence for the Y chromosome. Horse satellite-free centromeres provide unique models for mammalian centromere research. Despite extremely low genetic diversity of the Y chromosome, it has been possible to trace patrilines of breeds and pedigrees and show that Y variation was lost in the past approximately 2300 years owing to selective breeding. The high-quality reference genome has led to the development of three different SNP arrays and WGSs of almost 2000 modern individual horses. The collection of WGS of hundreds of ancient horses is unique and not available for any other domestic species. These tools and resources have led to global population studies dissecting the natural history of the species and genetic makeup and ancestry of modern breeds. Most importantly, the available tools and resources, together with the discovery of functional elements, are dissecting molecular causes of a growing number of Mendelian and complex traits. The improved understanding of molecular underpinnings of various traits continues to benefit the health and performance of the horse whereas also serving as a model for complex disease across species.

Published
2019

12. Mapping Outcomes and Registries Used in Current Danish Pharmacoepidemiological Research

Author

Thor Petersen C, Jensen KJ, Rosenzweig M, von Osmanski BI, Ankarfeldt MZ, and Petersen J

Subjects
pharmacoepidemiology, registries, review, denmark, drugs, Infectious and parasitic diseases, RC109-216
Abstract

Charlotte Thor Petersen,1,2 Kristoffer Jarlov Jensen,1 Mary Rosenzweig,2 Benedikte Irene von Osmanski,1,2 Mikkel Zöllner Ankarfeldt,1 Janne Petersen1,3 1Copenhagen Phase IV Unit (Phase4CPH), Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark; 2Life Science Insights Centre, DLI Market Intelligence, Copenhagen, Denmark; 3Section of Biostatistics, University of Copenhagen, Copenhagen, DenmarkCorrespondence: Charlotte Thor Petersen, Life Science Insights Centre, DLI Market Intelligence, Copenhagen, Denmark, Tel +45 30 35 20 43, Email ctp@dlimi.comPurpose: There is an increasing need for national and international pharmacoepidemiological studies based on high-quality real-world data of which the Danish registries are a valuable source. In lack of a complete overview of which data are used to assess real-world drug safety and effectiveness outcomes, we aimed to map the outcomes, data sources, and the reporting of outcome quality in recent pharmacoepidemiological studies.Methods: We conducted a systematic mapping review of pharmacoepidemiological studies based on Danish registries investigating drug safety and/or effectiveness, published in the period 2018– 2019, identified in PubMed and Scopus. Extraction included: Anatomical Therapeutic Chemical level 2 code for drug exposures, outcomes, outcome data sources, and quality of outcomes.Results: Of the 210 included studies, 96% used outcomes categorized as Clinical, 4% utilized outcomes categorized as Society-related, 5% used outcomes categorized as Healthcare cost and utilization, and 3% of the studies applied outcomes categorized as Patient-reported in which the percentages are not mutually exclusive. Diagnosis (66%) and Mortality (38%) were the two most utilized subcategories among those categorized as Clinical outcomes. Danish Health Data Authority and Statistics Denmark registries were the most reported outcome data sources (90%). Ninety-six studies (46%) reported one or more quality parameters related to their outcomes of interest with accuracy/validity being the most reported parameter (22%).Conclusion: The Danish registries support a wide range of outcomes. Across therapeutic areas, most studies investigate traditional clinical outcomes of disease and mortality based on data from a small number of available registries. In contrast, clinical and biochemical databases, despite potentially offering outcomes with high responsiveness, and the high-quality social and healthcare cost registries were rarely used as outcome data sources.Keywords: pharmacoepidemiology, registries, review, Denmark, drugs

Published
2022

13. Profiling Bispebjerg Acute Cohort: Database Formation, Acute Contact Characteristics of a Metropolitan Hospital, and Comparisons to Urban and Rural Hospitals in Denmark

Author

Gregersen R, Fox Maule C, Husum Bak-Jensen H, Linneberg A, Nielsen OW, Thomsen SF, Meyhoff CS, Dalhoff K, Krogsgaard M, Palm H, Christensen H, Porsbjerg C, Antonsen K, Rungby J, Haugaard SB, Petersen J, and Nielsen FE

Subjects
emergency medicine acute care urban-rural disparities registry-based research danish national registers epidemiology, Infectious and parasitic diseases, RC109-216
Abstract

Rasmus Gregersen,1,2 Cathrine Fox Maule,3 Henriette Husum Bak-Jensen,2 Allan Linneberg,3,4 Olav Wendelboe Nielsen,4,5 Simon Francis Thomsen,6 Christian S Meyhoff,2,4,7 Kim Dalhoff,4,8 Michael Krogsgaard,4,9 Henrik Palm,4,9 Hanne Christensen,4,10 Celeste Porsbjerg,4,11 Kristian Antonsen,12 Jørgen Rungby,2,4,13 Steen B Haugaard,2,4,13 Janne Petersen,3,14 Finn E Nielsen1,2 1Department of Emergency Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 2Copenhagen Center for Translational Research, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 3Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 4Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 5Department of Cardiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 6Department of Dermatology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 7Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 8Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 9Department of Orthopedics, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 10Department of Neurology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 11Department of Respiratory Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 12Executive Board, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 13Department of Endocrinology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark; 14Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkCorrespondence: Rasmus Gregersen, Department of Emergency Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, NV, 2400, Denmark, Email rasmus.gregersen@regionh.dkPurpose: To present a metropolitan cohort, Bispebjerg acute cohort (BAC), and compare patient characteristics and outcomes with patients from urban and rural hospitals in Denmark.Patients and Methods: We linked data from seven Danish nationwide registries and included all acute contacts to non-psychiatric hospitals in the years 2016– 2018. Acute hospital contacts to Bispebjerg and Frederiksberg Hospital constituted BAC, representing a solely metropolitan/urban catchment area. Patient characteristics and outcomes were compared to the rest of Denmark in an urban cohort (UrC) and a rural cohort (RuC), stratified by visit and hospitalization contact types.Results: We identified 4,063,420 acute hospital contacts in Denmark and BAC constituted 8.4% (n=343,200) of them. BAC had a higher proportion of visits (65.1%) compared with UrC (52.1%) and RuC (45.3%). Patients in BAC more often lived alone (visits: BAC: 34.8%, UrC: 30.6%, RuC: 29.2%; hospitalizations: BAC: 50.8%, UrC: 36.7%, RuC: 37.2%) and had temporary CPR number (visits: BAC: 4.4%, UrC: 1.9%, RuC: 1.6%; hospitalizations: BAC: 1.5%, UrC: 0.9%, RuC: 0.8%). Visit patients in BAC were younger (BAC: 36, UrC: 42, RuC: 45 years, median), more often students (BAC: 18.0%, UrC: 14.0%, RuC: 12.5%), and had more contacts due to infectious diseases (BAC: 19.8%, UrC: 14.1%, RuC: 6.2%) but less due to injuries (BAC: 40.0%, UrC: 43.8%, RuC: 60.7%). Hospitalized patients in BAC had higher median age (BAC: 64, UrC: 61, RuC: 64 years) and fewer were in employment than in UrC (BAC: 26.1%, UrC: 32.1%, RuC: 28.1%). BAC Hospitalizations had a lower death rate within 30 days than in RuC (BAC: 3.0% [2.9– 3.1%], UrC: 3.1% [3.0– 3.1%], RuC: 3.4% [3.3– 3.4%]), but a higher readmission-rate (BAC: 20.5% [20.3– 20.8%], UrC: 17.3% [17.2– 17.4%], RuC: 17.5% [17.5– 17.6%]).Conclusion: Significant differences between BAC, urban, and rural cohorts may be explained by differences in healthcare structure and sociodemographics of the catchment areas.Keywords: emergency medicine, acute care, urban-rural disparities, registry-based research, Danish national registers, epidemiology

Published
2022

18. Transient terahertz photoconductivity of insulating cuprates

Author

Petersen, J. C., Farahani, A., Sahota, D. G., Liang, Ruixing, and Dodge, J. S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We establish a detailed phenomenology of photocarrier transport in the copper oxide plane by studying the transient terahertz photoconductivity of Sr$_2$CuO$_2$Cl$_2$ and YBa$_2$Cu$_3$O$_6$. The peak photoconductivity saturates with fluence, decays on multiple picosecond timescales, and evolves into a state characterized by activated transport. The time dependence shows little change with fluence, indicating that the decay is governed by first-order recombination kinetics. We find that most photocarriers make a negligible contribution to the dc photoconductivity, and we estimate the intrinsic photocarrier mobility to be 0.6-0.7 cm$^2$/V s at early times, comparable to the mobility in chemically doped materials.

Published
2016
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21. Tracking heart surface features to determine myocardial contrast agent enrichment

Author

Sprenger J., Petersen J., Neumann N., Reichenspurner H., Russ D., Detter C., and Schlaefer A.

Subjects
object tracking, heart motion, surface features, Medicine
Abstract

Fluorescent cardiac imaging can be applied for intraoperative quality control after a coronary bypass grafting surgery to ensure the myocardial perfusion by evaluating the increasing contrast agent enrichment in the heart. The motion due to the beating heart impedes the interpretation of the contrast agent enrichment in the vessels and leads to noisy enrichment curves. We propose tracking of the heart surface features to compensate for the motion of the beating heart and thereby improve the analysis of the contrast agent enrichment. Furthermore, we propose a vessel segmentation pipeline for a local evaluation of contrast agent enrichment directly in the vessels.

Published
2021
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22. Prevalence and Medications of Atopic Dermatitis in Germany: Claims Data Analysis

Author

Hagenström K, Sauer K, Mohr N, Dettmann M, Glaeske G, Petersen J, Garbe C, Steimle T, and Augustin M

Subjects
epidemiology, frequency of illness, pharmaceutical supply, neurodermatitis, statutory health insurance, Infectious and parasitic diseases, RC109-216
Abstract

Kristina Hagenström,1 Kristin Sauer,1 Nicole Mohr,1 Marleen Dettmann,1 Gerd Glaeske,2 Jana Petersen,1 Claudia Garbe,1 Tim Steimle,3 Matthias Augustin1 1German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany; 2Research Center on Inequality and Social Policy, University of Bremen, Bremen, Germany; 3Techniker Krankenkasse, Hamburg, GermanyCorrespondence: Kristina HagenströmGerman Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, Hamburg, 20246, GermanyTel +49 (0) 40 7410 554 28Fax +49 (0) 40 7410 553 48Email k.hagenstroem@uke.deBackground: Information on the prevalence of atopic dermatitis (AD) varies greatly, and so far, only a few studies describe the healthcare of patients with AD in Germany.Objective: The aim of the study is to describe the prevalence and medications of people with AD in Germany.Methods: Health insurance data for the year 2019 were examined. Prevalence rates, the severity of disease, comorbidities and pharmaceutical supply were analyzed. Insured persons with AD were identified with at least one outpatient or inpatient International Classification Code of Diseases (L20).Results: In 2019, 4.21% [95% CI 4.21− 4.22%] of insured persons had AD (3.6 million). Women were affected slightly more frequently than men (4.74% [95% CI 4.73− 4.74%] and 3.64% [95% CI 3.64− 3.65%]). Adolescents and children under the age of 15 had the highest prevalence of AD compared to other age groups (9.44% [95% CI 9.42− 9.46%]). Majority of the insured persons with AD were affected by a mild to moderate form of the disease. The most common co-morbidity was infections of the skin (RR 5.00 [95% CI 4.97− 5.02%]). Some patients were treated by a dermatologist, while others by a general practitioner, 39.10% and 36.74%, respectively. Of the anti-inflammatory drugs, systemic glucocorticosteroids preparations were used most frequently and were most frequently prescribed by the general practitioner. With a total of 42,841 prescriptions (1.53%), methotrexate (third-line treatment option) was prescribed more frequently than ciclosporin with 19,628 prescriptions (0.70%) or azathioprine with 25,696 prescriptions (0.92%). Ciclosporin (first-line treatment option) was prescribed much more frequently by a dermatologist (44.00% versus 14.32% by general practitioner). The biological dupilumab was prescribed 30,801 times (1,10%) and was also primarily prescribed by a dermatologist (66.67%).Conclusion: The present results reveal that a specialist treats approximately one-third of the patients with AD and that there is still a drug undersupply in some cases, especially concerning innovative drugs.Keywords: epidemiology, frequency of illness, pharmaceutical supply, neurodermatitis, statutory health insurance

Published
2021

23. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Günther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C.M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Müller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Löbermann, M., Götze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J.-P., Moreno, C., Müller, T., Muche, M., Epple, H.-J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N.H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Härter, G., Herder, M., Heuchel, T., Heuer, S., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, K.&R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K.J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K.G., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Müllhaupt, Beat, Schulze zur Wiesch, Julian, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, and Sarrazin, Christoph

Published
2021
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25. ROS-dependent modulation of Rab7 contributes to chronic pain processing

Author

Kallenborn-Gerhardt, W, Moeser, C, Lorenz, JE, Steger, M, Heidler, J, Scheving, R, Petersen, J, Lu, R, Edinger, AL, Tegeder, I, Geisslinger, G, Heide, H, Wittig, I, and Schmidtko, A

Subjects
Pharmacology and Pharmaceutical Sciences, Medical Physiology, Pharmacology & Pharmacy
Published
2017

26. Scalable photonic network architecture based on motional averaging in room temperature gas

Author

Borregaard, J., Zugenmaier, M., Petersen, J. M., Shen, H., Vasilakis, G., Jensen, K., Polzik, E. S., and Sørensen, A. S.

Subjects
Quantum Physics
Abstract

Quantum interfaces between photons and ensembles of atoms have emerged as powerful tools for quantum technologies. A major objective for such interfaces is high fidelity storage and retrieval of a photon in a collective quantum state of many atoms. This requires long-lived collective superposition states, which is typically achieved with immobilized atoms. Thermal atomic vapors, which present a simple and scalable resource, have, so far, only been used for continuous variable processing or for discrete variable processing on short time scales where atomic motion is negligible. We develop a theory based on the concept of motional averaging to enable room temperature discrete variable quantum memories and coherent single photon sources. We show that by choosing the interaction time so that atoms kept under spin protecting conditions can cross the light beam several times during the interaction combined with suitable spectral filtering, we erase the "which atom" information and obtain an efficient and homogenous coupling between all atoms and the light. Heralded single excitations can thus be created and stored as collective spinwaves, which can later be read out to produce coherent single photons in a scalable fashion. We demonstrate the feasibility of this approach to scalable quantum memories with a proof-of-principle experiment with room temperature atoms contained in microcells with spin protecting coating, placed inside an optical cavity. The experiment is performed at conditions corresponding to a few photons per pulse and clearly demonstrates a long coherence time of the forward scattered photons, which is the essential feature of the motional averaging., Comment: 22 pages total, the first 10 pages are the main article and the remaining pages are the supplemental material

Published
2015
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27. cccDNA Maintenance in Chronic Hepatitis B – Targeting the Matrix of Viral Replication

Author

Dandri M and Petersen J

Subjects
hepatitis b virus, cccdna, animal models, human liver chimeric mice, antiviral therapy, Infectious and parasitic diseases, RC109-216
Abstract

Maura Dandri,1,2 Joerg Petersen3 1Department of Internal Medicine, University Medical Center Hamburg – Eppendorf, Hamburg, Germany; 2German Center for Infection Research (DZIF), Hamburg-Luebeck-Borstel-Riems Site, Germany; 3Institute for Interdisciplinary Medicine, Asklepios Klinik St Georg, University of Hamburg, Hamburg, GermanyCorrespondence: Maura DandriDepartment of Internal Medicine, University Medical Center Hamburg – Eppendorf, Martinistr. 52, Hamburg D - 20246, GermanyTel + 49 40 7410 52949Fax + 49 40 7410 57232Email m.dandri@uke.deJoerg PetersenLiver Unit, IFI Institute at the Asklepios Klinik St Georg Hamburg, Haus L, Lohmühlenstr. 5, Hamburg 20099, GermanyTel +49 40 284 07 60 0Fax +49 40 284 07 60 222Email petersen@ifi-medizin.deAbstract: Chronic hepatitis B is a numerically important cause of cirrhosis and hepatocellular carcinoma, despite an effective prophylactic vaccine and well-tolerated and effective oral antivirals. Both the incapacity of the immune system to clear hepatitis B virus (HBV) infection and the unique replication strategies adopted by HBV are considered key determinants of HBV chronicity. In this regard, the formation of the HBV DNA minichromosome, the covalently closed circular DNA (cccDNA), in the nucleus of infected hepatocytes, is essential not only for the production of all viral proteins but also for HBV persistence even after long-term antiviral therapy. Licensed polymerase inhibitors target the HBV reverse transcriptase activity, control the disease with long-term therapy but fail to eliminate the cccDNA. Consequently, the production of viral RNAs and proteins, including the hepatitis B surface antigen (HBsAg), is not abolished. Novel therapeutic efforts that are in the pipeline for early clinical trials explore novel targets and molecules. Such therapeutic efforts focus on achieving a functional cure, which is defined by the loss of HBsAg and undetectable HBV DNA levels in serum. Since a true cure of HBV infection requires the elimination of the cccDNA from infected cells, comprehension of the mechanisms implicated in cccDNA biogenesis, regulation and stability appears necessary to achieve HBV eradication. In this review, we will summarize the state of knowledge on cccDNA metabolism, focusing on insights suggesting potential weak points of the cccDNA that may be key for the development of therapeutic approaches and design of clinical trials aiming at lowering cccDNA loads and activity.Keywords: hepatitis B virus, cccDNA, animal models, human liver chimeric mice, antiviral therapy

Published
2020

28. Prevalence of Congenital Hemolytic Disorders in Denmark, 2000–2016

Author

Hansen DL, Glenthøj A, Möller S, Biemond BJ, Andersen K, Gaist D, Petersen J, and Frederiksen H

Subjects
hemolytic anemia, thalassemia, sickle cell disease, hereditary spherocytosis, hemoglobinopathies, sickle cell anemia, Infectious and parasitic diseases, RC109-216
Abstract

Dennis Lund Hansen,1,2 Andreas Glenthøj,3 Sören Möller,1,4 Bart J Biemond,5 Kjeld Andersen,1,6 David Gaist,1,7 Jesper Petersen,3 Henrik Frederiksen1,2 1Department of Clinical Research, University of Southern Denmark, Odense, Denmark; 2Department of Hematology, Odense University Hospital, Odense, Denmark; 3Department of Hematology, Center for Hemoglobinopathies, Herlev and Gentofte Hospital, Herlev, Denmark; 4OPEN, Odense University Hospital, Odense, Denmark; 5Department of Hematology, Amsterdam University Medical Centre’s, Amsterdam, Netherlands; 6Department of Mental Health - Odense, Region of Southern Denmark, Odense, Denmark; 7Neurology Research Unit, Department of Neurology, Odense University Hospital, Odense, DenmarkCorrespondence: Dennis Lund Hansen Email dlh@dadlnet.dkBackground: Congenital red blood cell (RBC) disorders, such as hemoglobinopathies, are frequent worldwide but with large geographical variation. Growing migration has increased the number of patients with RBC disorders in formerly low prevalence countries, eg, Denmark. However, accurate prevalences are unknown.Methods: Patients with a registered diagnosis of congenital hemolysis in the Danish National Patient Register between 1977 and 2016 were linked to a national laboratory database of RBC disorders and the Danish civil registration system. We calculate annual age- and sex-specific prevalences of the congenital hemolytic disorders from 2000 to 2016.Results: Prevalences of all subtypes of congenital hemolytic disorders increased during the study period. The prevalence of hereditary spherocytosis increased 1.73 times between 2000 and 2015, from 10.2/105 persons to 17.7/105 persons. Alpha thalassemia trait had a prevalence of 0.5/105 persons in 2000, but increased 41 times to 19.2/105 persons in 2015. Beta thalassemia minor increased eightfold from 4.5/105 persons in 2000 to 34.9/105 persons in 2015. Likewise, sickle cell trait increased 11 times from 0.7/105 persons in 2000 to 8.1/105 persons in 2015, whereas sickle cell disease increased from 0.5/105 persons to 2.7/105 persons in 2015, a fivefold increase.Conclusion: The prevalence of congenital RBC disorders in Denmark is increasing. The hemoglobinopathy traits now have prevalences as high as hereditary spherocytosis. These estimates of congenital hemolytic disorders in Denmark emphasize that inborn hemoglobin disorders are a public health concern, even in some formerly low prevalence countries.Keywords: hemolytic anemia, thalassemia, sickle cell disease, hereditary spherocytosis, hemoglobinopathies, sickle cell anemia

Published
2020

30. A systematic umbrella review and meta-meta-analysis of eHealth and mHealth interventions for improving lifestyle behaviours.

Author

Singh, B, Ahmed, M, Staiano, AE, Gough, C, Petersen, J, Vandelanotte, C, Kracht, C, Huong, C, Yin, Z, Vasiloglou, MF, Pan, C-C, Short, CE, Mclaughlin, M, von Klinggraeff, L, Pfledderer, CD, Moran, LJ, Button, AM, Maher, CA, Singh, B, Ahmed, M, Staiano, AE, Gough, C, Petersen, J, Vandelanotte, C, Kracht, C, Huong, C, Yin, Z, Vasiloglou, MF, Pan, C-C, Short, CE, Mclaughlin, M, von Klinggraeff, L, Pfledderer, CD, Moran, LJ, Button, AM, and Maher, CA

Abstract

The aim of this meta-meta-analysis was to systematically review randomised controlled trial (RCT) evidence examining the effectiveness of e- and m-Health interventions designed to improve physical activity, sedentary behaviour, healthy eating and sleep. Nine electronic databases were searched for eligible studies published from inception to 1 June 2023. Systematic reviews with meta-analyses of RCTs that evaluate e- and m-Health interventions designed to improve physical activity, sedentary behaviour, sleep and healthy eating in any adult population were included. Forty-seven meta-analyses were included, comprising of 507 RCTs and 206,873 participants. Interventions involved mobile apps, web-based and SMS interventions, with 14 focused on physical activity, 3 for diet, 4 for sleep and 26 evaluating multiple behaviours. Meta-meta-analyses showed that e- and m-Health interventions resulted in improvements in steps/day (mean difference, MD = 1329 [95% CI = 593.9, 2065.7] steps/day), moderate-to-vigorous physical activity (MD = 55.1 [95% CI = 13.8, 96.4] min/week), total physical activity (MD = 44.8 [95% CI = 21.6, 67.9] min/week), sedentary behaviour (MD = -426.3 [95% CI = -850.2, -2.3] min/week), fruit and vegetable consumption (MD = 0.57 [95% CI = 0.11, 1.02] servings/day), energy intake (MD = -102.9 kcals/day), saturated fat consumption (MD = -5.5 grams/day), and bodyweight (MD = -1.89 [95% CI = -2.42, -1.36] kg). Analyses based on standardised mean differences (SMD) showed improvements in sleep quality (SMD = 0.56, 95% CI = 0.40, 0.72) and insomnia severity (SMD = -0.90, 95% CI = -1.14, -0.65). Most subgroup analyses were not significant, suggesting that a variety of e- and m-Health interventions are effective across diverse age and health populations. These interventions offer scalable and accessible approaches to help individuals adopt and sustain healthier behaviours, with implications for broader public health and healthcare challenges.

Published
2024

31. New developments in AMPK and mTORC1 cross-talk

Author

Smiles, WJ, Ovens, AJ, Kemp, BE, Galic, S, Petersen, J, Oakhill, JS, Smiles, WJ, Ovens, AJ, Kemp, BE, Galic, S, Petersen, J, and Oakhill, JS

Abstract

Metabolic homeostasis and the ability to link energy supply to demand are essential requirements for all living cells to grow and proliferate. Key to metabolic homeostasis in all eukaryotes are AMPK and mTORC1, two kinases that sense nutrient levels and function as counteracting regulators of catabolism (AMPK) and anabolism (mTORC1) to control cell survival, growth and proliferation. Discoveries beginning in the early 2000s revealed that AMPK and mTORC1 communicate, or cross-talk, through direct and indirect phosphorylation events to regulate the activities of each other and their shared protein substrate ULK1, the master initiator of autophagy, thereby allowing cellular metabolism to rapidly adapt to energy and nutritional state. More recent reports describe divergent mechanisms of AMPK/mTORC1 cross-talk and the elaborate means by which AMPK and mTORC1 are activated at the lysosome. Here, we provide a comprehensive overview of current understanding in this exciting area and comment on new evidence showing mTORC1 feedback extends to the level of the AMPK isoform, which is particularly pertinent for some cancers where specific AMPK isoforms are implicated in disease pathogenesis.

Published
2024

32. Metrics reloaded: recommendations for image analysis validation

Author

Maier-Hein, L., Reinke, A., Godau, P., Tizabi, M.D., Buettner, F., Christodoulou, E., Glocker, B., Isensee, F., Kleesiek, J., Kozubek, M., Reyes, M., Riegler, M.A., Wiesenfarth, M., Kavur, A.E., Sudre, C.H., Baumgartner, M., Eisenmann, M., Heckmann-Notzel, D., Radsch, T., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Blaschko, M.B., Cardoso, M.J., Cheplygina, V., Cimini, B.A., Collins, G.S., Farahani, K., Ferrer, L., Galdran, A., Ginneken, B. van, Haase, R., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Karthikesalingam, A., Kofler, F., Kopp-Schneider, A., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G.J., Madani, A., Maier-Hein, K., Martel, A.L., Mattson, P., Meijering, E., Menze, B., Moons, K.G., Muller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rajpoot, N., Rieke, N., Saez-Rodriguez, J., Sanchez, C.I., Shetty, S., Smeden, M. van, Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Calster, B. van, Varoquaux, G., Jager, P.F., Maier-Hein, L., Reinke, A., Godau, P., Tizabi, M.D., Buettner, F., Christodoulou, E., Glocker, B., Isensee, F., Kleesiek, J., Kozubek, M., Reyes, M., Riegler, M.A., Wiesenfarth, M., Kavur, A.E., Sudre, C.H., Baumgartner, M., Eisenmann, M., Heckmann-Notzel, D., Radsch, T., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Blaschko, M.B., Cardoso, M.J., Cheplygina, V., Cimini, B.A., Collins, G.S., Farahani, K., Ferrer, L., Galdran, A., Ginneken, B. van, Haase, R., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Karthikesalingam, A., Kofler, F., Kopp-Schneider, A., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G.J., Madani, A., Maier-Hein, K., Martel, A.L., Mattson, P., Meijering, E., Menze, B., Moons, K.G., Muller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rajpoot, N., Rieke, N., Saez-Rodriguez, J., Sanchez, C.I., Shetty, S., Smeden, M. van, Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Calster, B. van, Varoquaux, G., and Jager, P.F.

Abstract

Contains fulltext : 305368.pdf (Publisher’s version ) (Closed access), Increasing evidence shows that flaws in machine learning (ML) algorithm validation are an underestimated global problem. In biomedical image analysis, chosen performance metrics often do not reflect the domain interest, and thus fail to adequately measure scientific progress and hinder translation of ML techniques into practice. To overcome this, we created Metrics Reloaded, a comprehensive framework guiding researchers in the problem-aware selection of metrics. Developed by a large international consortium in a multistage Delphi process, it is based on the novel concept of a problem fingerprint-a structured representation of the given problem that captures all aspects that are relevant for metric selection, from the domain interest to the properties of the target structure(s), dataset and algorithm output. On the basis of the problem fingerprint, users are guided through the process of choosing and applying appropriate validation metrics while being made aware of potential pitfalls. Metrics Reloaded targets image analysis problems that can be interpreted as classification tasks at image, object or pixel level, namely image-level classification, object detection, semantic segmentation and instance segmentation tasks. To improve the user experience, we implemented the framework in the Metrics Reloaded online tool. Following the convergence of ML methodology across application domains, Metrics Reloaded fosters the convergence of validation methodology. Its applicability is demonstrated for various biomedical use cases.

Published
2024

33. Understanding metric-related pitfalls in image analysis validation

Author

Reinke, A., Tizabi, M.D., Baumgartner, M., Eisenmann, M., Heckmann-Notzel, D., Kavur, A.E., Radsch, T., Sudre, C.H., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Buettner, F., Cardoso, M.J., Cheplygina, V., Chen, J., Christodoulou, E., Cimini, B.A., Farahani, K., Ferrer, L., Galdran, A., Ginneken, B. van, Glocker, B., Godau, P., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Isensee, F., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Kleesiek, J., Kofler, F., Kooi, T., Kopp-Schneider, A., Kozubek, M., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G.J., Madani, A., Maier-Hein, K., Martel, A.L., Meijering, E., Menze, B., Moons, K.G., Muller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rafelski, S.M., Rajpoot, N., Reyes, M., Riegler, M.A., Rieke, N., Saez-Rodriguez, J., Sanchez, C.I., Shetty, S., Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Calster, B. van, Varoquaux, G., Yaniv, Z.R., Jager, P.F., Maier-Hein, L., Reinke, A., Tizabi, M.D., Baumgartner, M., Eisenmann, M., Heckmann-Notzel, D., Kavur, A.E., Radsch, T., Sudre, C.H., Acion, L., Antonelli, M., Arbel, T., Bakas, S., Benis, A., Buettner, F., Cardoso, M.J., Cheplygina, V., Chen, J., Christodoulou, E., Cimini, B.A., Farahani, K., Ferrer, L., Galdran, A., Ginneken, B. van, Glocker, B., Godau, P., Hashimoto, D.A., Hoffman, M.M., Huisman, M., Isensee, F., Jannin, P., Kahn, C.E., Kainmueller, D., Kainz, B., Karargyris, A., Kleesiek, J., Kofler, F., Kooi, T., Kopp-Schneider, A., Kozubek, M., Kreshuk, A., Kurc, T., Landman, B.A., Litjens, G.J., Madani, A., Maier-Hein, K., Martel, A.L., Meijering, E., Menze, B., Moons, K.G., Muller, H., Nichyporuk, B., Nickel, F., Petersen, J., Rafelski, S.M., Rajpoot, N., Reyes, M., Riegler, M.A., Rieke, N., Saez-Rodriguez, J., Sanchez, C.I., Shetty, S., Summers, R.M., Taha, A.A., Tiulpin, A., Tsaftaris, S.A., Calster, B. van, Varoquaux, G., Yaniv, Z.R., Jager, P.F., and Maier-Hein, L.

Abstract

Contains fulltext : 305370.pdf (Publisher’s version ) (Closed access), Validation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence research and its translation into practice. However, increasing evidence shows that, particularly in image analysis, metrics are often chosen inadequately. Although taking into account the individual strengths, weaknesses and limitations of validation metrics is a critical prerequisite to making educated choices, the relevant knowledge is currently scattered and poorly accessible to individual researchers. Based on a multistage Delphi process conducted by a multidisciplinary expert consortium as well as extensive community feedback, the present work provides a reliable and comprehensive common point of access to information on pitfalls related to validation metrics in image analysis. Although focused on biomedical image analysis, the addressed pitfalls generalize across application domains and are categorized according to a newly created, domain-agnostic taxonomy. The work serves to enhance global comprehension of a key topic in image analysis validation.

Published
2024

34. Trait matching of flower visitors and crops predicts fruit set better than trait diversity

Author

Garibaldi, LA, Bartomeus, I, Bommarco, R, Klein, AM, Cunningham, SA, Aizen, MA, Boreux, V, Garratt, MPD, Carvalheiro, LG, Kremen, C, Morales, CL, Schüepp, C, Chacoff, NP, Freitas, BM, Gagic, V, Holzschuh, A, Klatt, BK, Krewenka, KM, Krishnan, S, Mayfield, MM, Motzke, I, Otieno, M, Petersen, J, Potts, SG, Ricketts, TH, Rundlöf, M, Sciligo, A, Sinu, PA, Steffan-Dewenter, I, Taki, H, Tscharntke, T, Vergara, CH, Viana, BF, and Woyciechowski, M

Subjects
agroecosystems, body size, ecosystem functioning, ecosystem services, mouthpart length, nectar accessibility, pollination, trait evenness, trait richness, Ecological Applications, Environmental Science and Management, Ecology
Abstract

Understanding the relationships between trait diversity, species diversity and ecosystem functioning is essential for sustainable management. For functions comprising two trophic levels, trait matching between interacting partners should also drive functioning. However, the predictive ability of trait diversity and matching is unclear for most functions, particularly for crop pollination, where interacting partners did not necessarily co-evolve. World-wide, we collected data on traits of flower visitors and crops, visitation rates to crop flowers per insect species and fruit set in 469 fields of 33 crop systems. Through hierarchical mixed-effects models, we tested whether flower visitor trait diversity and/or trait matching between flower visitors and crops improve the prediction of crop fruit set (functioning) beyond flower visitor species diversity and abundance. Flower visitor trait diversity was positively related to fruit set, but surprisingly did not explain more variation than flower visitor species diversity. The best prediction of fruit set was obtained by matching traits of flower visitors (body size and mouthpart length) and crops (nectar accessibility of flowers) in addition to flower visitor abundance, species richness and species evenness. Fruit set increased with species richness, and more so in assemblages with high evenness, indicating that additional species of flower visitors contribute more to crop pollination when species abundances are similar. Synthesis and applications. Despite contrasting floral traits for crops world-wide, only the abundance of a few pollinator species is commonly managed for greater yield. Our results suggest that the identification and enhancement of pollinator species with traits matching those of the focal crop, as well as the enhancement of pollinator richness and evenness, will increase crop yield beyond current practices. Furthermore, we show that field practitioners can predict and manage agroecosystems for pollination services based on knowledge of just a few traits that are known for a wide range of flower visitor species. Despite contrasting floral traits for crops world-wide, only the abundance of a few pollinator species is commonly managed for greater yield. Our results suggest that the identification and enhancement of pollinator species with traits matching those of the focal crop, as well as the enhancement of pollinator richness and evenness, will increase crop yield beyond current practices. Furthermore, we show that field practitioners can predict and manage agroecosystems for pollination services based on knowledge of just a few traits that are known for a wide range of flower visitor species.

Published
2015

36. Deterministic quantum teleportation between distant atomic objects

Author

Krauter, H., Salart, D., Muschik, C. A., Petersen, J. M., Shen, Heng, Fernholz, T., and Polzik, E. S.

Subjects
Quantum Physics
Abstract

Quantum teleportation is a key ingredient of quantum networks and a building block for quantum computation. Teleportation between distant material objects using light as the quantum information carrier has been a particularly exciting goal. Here we demonstrate a new element of the quantum teleportation landscape, the deterministic continuous variable (cv) teleportation between distant material objects. The objects are macroscopic atomic ensembles at room temperature. Entanglement required for teleportation is distributed by light propagating from one ensemble to the other. Quantum states encoded in a collective spin state of one ensemble are teleported onto another ensemble using this entanglement and homodyne measurements on light. By implementing process tomography, we demonstrate that the experimental fidelity of the quantum teleportation is higher than that achievable by any classical process. Furthermore, we demonstrate the benefits of deterministic teleportation by teleporting a dynamically changing sequence of spin states from one distant object onto another.

Published
2012
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37. Possible observation of parametrically amplified coherent phasons in K0.3MoO3 using time-resolved extreme-ultraviolet ARPES

Author

Liu, H. Y., Gierz, I., Petersen, J. C., Kaiser, S., Simoncig, A., Cavalieri, A. L., Cacho, C., Turcu, I. C. E., Springate, E., Frassetto, F., Poletto, L., Dhesi, S. S., Xu, Z. -A., Cuk, T., Merlin, R., and Cavalleri, A.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

We use time- and angle-resolved photoemission spectroscopy (tr-ARPES) in the Extreme Ultraviolet (EUV) to measure the time- and momentum-dependent electronic structure of photo-excited K0.3MoO3. Prompt depletion of the Charge Density Wave (CDW) condensate launches coherent oscillations of the amplitude mode, observed as a 1.7-THz-frequency modulation of the bonding band position. In contrast, the anti-bonding band oscillates at about half this frequency. We attribute these oscillations to coherent excitation of phasons via parametric amplification of phase fluctuations., Comment: 4 figures

Published
2012
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38. Bi-directional ultrafast electric-field gating of interlayer transport in a cuprate superconductor

Author

Dienst, A., Hoffmann, M. C., Fausti, D., Petersen, J., Pyon, S., Takayama, T., Takagi, H., and Cavalleri, A.

Subjects
Condensed Matter - Superconductivity
Abstract

In cuprate superconductors, tunneling between planes makes possible three-dimensional coherent transport. However, the interlayer tunnelling amplitude is reduced when an order-parameter phase gradient between planes is established. As such, c-axis superconductivity can be weakened if a strong electric field is applied along the c axis. We use high-field single-cycle terahertz pulses to gate interlayer coupling in La1.84Sr0.16CuO4. We induce ultrafast oscillations between superconducting and resistive states and switch the plasmon response on and off, without reducing the density of Cooper pairs. Indeed, in-plane superconductivity remains unperturbed throughout, revealing a non-equilibrium state in which the dimensionality of the superconductor is time dependent. The gating frequency is determined by the electric field strength, in the spirit of the ac Josephson effect. Non-dissipative, bi-directional gating of superconductive coupling is of interest for device applications in ultrafast nanoelectronics. It is also a new example of nonlinear terahertz physics, applicable to nanoplasmonics and active metamaterials.

Published
2011
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39. A Layer Correlation technique for pion energy calibration at the 2004 ATLAS Combined Beam Test

Author

Abat, E., Abdallah, J. M., Addy, T. N., Adragna, P., Aharrouche, M., Ahmad, A., Akesson, T. P. A., Aleksa, M., Alexa, C., Anderson, K., Andreazza, A., Anghinolfi, F., Antonaki, A., Arabidze, G., Arik, E., Atkinson, T., Baines, J., Baker, O. K., Banfi, D., Baron, S., Barr, A. J., Beccherle, R., Beck, H. P., Belhorma, B., Bell, P. J., Benchekroun, D., Benjamin, D. P., Benslama, K., Kuutmann, E. Bergeaas, Bernabeu, J., Bertelsen, H., Binet, S., Biscarat, C., Boldea, V., Bondarenko, V. G., Boonekamp, M., Bosman, M., Bourdarios, C., Broklova, Z., Chromek, D. Burckhart, Bychkov, V., Callahan, J., Calvet, D., Canneri, M., Garrido, M. Capeáns, Caprini, M., Sas, L. Cardiel, Carli, T., Carminati, L., Carvalho, J., Cascella, M., Castillo, M. V., Catinaccio, A., Cauz, D., Cavalli, D., Sforza, M. Cavalli, Cavasinni, V., Cetin, S. A., Chen, H., Cherkaoui, R., Chevalier, L., Chevallier, F., Chouridou, S., Ciobotaru, M., Citterio, M., Clark, A., Cleland, B., Cobal, M., Cogneras, E., Muino, P. Conde, Consonni, M., Constantinescu, S., Cornelissen, T., Correard, S., Radu, A. Corso, Costa, G., Costa, M. J., Costanzo, D., Cuneo, S., Cwetanski, P., Da Silva, D., Dam, M., Dameri, M., Danielsson, H. O., Dannheim, D., Darbo, G., Davidek, T., De, K., Defay, P. O., Dekhissi, B., Del Peso, J., Del Prete, T., Delmastro, M., Derue, F., Di Ciaccio, L., Di Girolamo, B., Dita, S., Dittus, F., Djama, F., Djobava, T., Dobos, D., Dobson, M., Dolgoshein, B. A., Dotti, A., Drake, G., Drasal, Z., Dressnandt, N., Driouchi, C., Drohan, J., Ebenstein, W. L., Eerola, P., Efthymiopoulos, I., Egorov, K., Eifert, T. F., Einsweiler, K., Kacimi, M. El, Elsing, M., Emelyanov, D., Escobar, C., Etienvre, A. I., Fabich, A., Facius, K., Fakhr-Edine, A. I., Fanti, M., Farbin, A., Farthouat, P., Fassouliotis, D., Fayard, L., Febbraro, R., Fedin, O. L., Fenyuk, A., Fergusson, D., Ferrari, P., Ferrari, R., Ferreira, B. C., Ferrer, A., Ferrere, D., Filippini, G., Flick, T., Fournier, D., Francavilla, P., Francis, D., Froeschl, R., Froidevaux, D., Fullana, E., Gadomski, S., Gagliardi, G., Gagnon, P., Gallas, M., Gallop, B. J., Gameiro, S., Gan, K. K., Garcia, R., Garcia, C., Gavrilenko, I. L., Gemme, C., Gerlach, P., Ghodbane, N., Giakoumopoulou, V., Giangiobbe, V., Giokaris, N., Glonti, G., Goettfert, T., Golling, T., Gollub, N., Gomes, A., Gomez, M. D., Gonzalez-Sevilla, S., Goodrick, M. J., Gorfine, G., Gorini, B., Goujdami, D., Grahn, K-J., Grenier, P., Grigalashvili, N., Grishkevich, Y., Grosse-Knetter, J., Gruwe, M., Guicheney, C., Gupta, A., Haeberli, C., Haertel, R., Hajduk, Z., Hakobyan, H., Hance, M., Hansen, J. D., Hansen, P. H., Hara, K., Harvey Jr., A., Hawkings, R. J., Heinemann, F. E. W., Correia, A. Henriques, Henss, T., Hervas, L., Higon, E., Hill, J. C., Hoffman, J., Hostachy, J. Y., Hruska, I., Hubaut, F., Huegging, F., Hulsbergen, W., Hurwitz, M., Iconomidou-Fayard, L., Jansen, E., Plante, I. Jen-La, Johansson, P. D. C., Jon-And, K., Joos, M., Jorgensen, S., Joseph, J., Kaczmarska, A., Kado, M., Karyukhin, A., Kataoka, M., Kayumov, F., Kazarov, A., Keener, P. T., Kekelidze, G. D., Kerschen, N., Kersten, S., Khomich, A., Khoriauli, G., Khramov, E., Khristachev, A., Khubua, J., Kittelmann, T. H., Klingenberg, R., Klinkby, E. B., Kodys, P., Koffas, T., Kolos, S., Konovalov, S. P., Konstantinidis, N., Kopikov, S., Korolkov, I., Kostyukhin, V., Kovalenko, S., Kowalski, T. Z., Krüger, K., Kramarenko, V., Kudin, L. G., Kulchitsky, Y., Lacasta, C., Lafaye, R., Laforge, B., Lampl, W., Lanni, F., Laplace, S., Lari, T., Bihan, A-C. Le, Lechowski, M., Ledroit-Guillon, F., Lehmann, G., Leitner, R., Lelas, D., Lester, C. G., Liang, Z., Lichard, P., Liebig, W., Lipniacka, A., Lokajicek, M., Louchard, L., Lourerio, K. F., Lucotte, A., Luehring, F., Lund-Jensen, B., Lundberg, B., Ma, H., Mackeprang, R., Maio, A., Maleev, V. P., Malek, F., Mandelli, L., Maneira, J., Mangin-Brinet, M., Manousakis, A., Mapelli, L., Marques, C., Garcia, S. Marti i, Martin, F., Mathes, M., Mazzanti, M., McFarlane, K. W., McPherson, R., Mchedlidze, G., Mehlhase, S., Meirosu, C., Meng, Z., Meroni, C., Mialkovski, V., Mikulec, B., Milstead, D., Minashvili, I., Mindur, B., Mitsou, V. A., Moed, S., Monnier, E., Moorhead, G., Morettini, P., Morozov, S. V., Mosidze, M., Mouraviev, S. V., Moyse, E. W. J., Munar, A., Myagkov, A., Nadtochi, A. V., Nakamura, K., Nechaeva, P., Negri, A., Nemecek, S., Nessi, M., Nesterov, S. Y., Newcomer, F. M., Nikitine, I., Nikolaev, K., Nikolic-Audit, I., Ogren, H., Oh, S. H., Oleshko, S. B., Olszowska, J., Onofre, A., Aranda, C. Padilla, Paganis, S., Pallin, D., Pantea, D., Paolone, V., Parodi, F., Parsons, J., Parzhitskiy, S., Pasqualucci, E., Passmored, S. M., Pater, J., Patrichev, S., Peez, M., Reale, V. Perez, Perini, L., Peshekhonov, V. D., Petersen, J., Petersen, T. C., Petti, R., Phillips, P. W., Pina, J., Pinto, B., Podlyski, F., Poggioli, L., Poppleton, A., Poveda, J., Pralavorio, P., Pribyl, L., Price, M. J., Prieur, D., Puigdengoles, C., Puzo, P., Røhne, O., Ragusa, F., Rajagopalan, S., Reeves, K., Reisinger, I., Rembser, C., Renstrom, P. A. Bruckman. de., Reznicek, P., Ridel, M., Risso, P., Riu, I., Robinson, D., Roda, C., Roe, S., Rohne, O., Romaniouk, A., Rousseau, D., Rozanov, A., Ruiz, A., Rusakovich, N., Rust, D., Ryabov, Y. F., Ryjov, V., Salto, O., Salvachua, B., Salzburger, A., Sandaker, H., Rios, C. Santamarina, Santi, L., Santoni, C., Saraiva, J. G., Sarri, F., Sauvage, G., Says, L. P., Schaefer, M., Schegelsky, V. A., Schiavi, C., Schieck, J., Schlager, G., Schlereth, J., Schmitt, C., Schultes, J., Schwemling, P., Schwindling, J., Seixas, J. M., Seliverstov, D. M., Serin, L., Sfyrla, A., Shalanda, N., Shaw, C., Shin, T., Shmeleva, A., Silva, J., Simion, S., Simonyan, M., Sloper, J. E., Smirnov, S. Yu., Smirnova, L., Solans, C., Solodkov, A., Solovianov, O., Soloviev, I., Sosnovtsev, V. V., Spanó, F., Speckmayer, P., Stancu, S., Stanek, R., Starchenko, E., Straessner, A., Suchkov, S. I., Suk, M., Szczygiel, R., Tarrade, F., Tartarelli, F., Tas, P., Tayalati, Y., Tegenfeldt, F., Teuscher, R., Thioye, M., Tikhomirov, V. O., Timmermans, C. J. W. P., Tisserant, S., Toczek, B., Tremblet, L., Troncon, C., Tsiareshka, P., Tyndel, M., Unel, M. Karagoez., Unal, G., Unel, G., Usai, G., Van Berg, R., Valero, A., Valkar, S., Valls, J. A., Vandelli, W., Vannucci, F., Vartapetian, A., Vassilakopoulos, V. I., Vasilyeva, L., Vazeille, F., Vernocchi, F., Vetter-Cole, Y., Vichou, I., Vinogradov, V., Virzi, J., Vivarelli, I., Vivie, J. B. de., Volpi, M., Anh, T. Vu, Wang, C., Warren, M., Weber, J., Weber, M., Weidberg, A. R., Weingarten, J., Wells, P. S., Werner, P., Wheeler, S., Wiessmann, M., Wilkens, H., Williams, H. H., Wingerter-Seez, I., Yasu, Y., Zaitsev, A., Zenin, A., Zenis, T., Zenonos, Z., Zhang, H., Zhelezko, A., and Zhou, N.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A new method for calibrating the hadron response of a segmented calorimeter is developed and successfully applied to beam test data. It is based on a principal component analysis of energy deposits in the calorimeter layers, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in front of and between the calorimeters of the ATLAS experiment were calculated with simulated Geant4 Monte Carlo events and used to reconstruct the energy of pions impinging on the calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. For pion beams with energies between 20 GeV and 180 GeV, the particle energy is reconstructed within 3% and the energy resolution is improved by between 11% and 25% compared to the resolution at the electromagnetic scale., Comment: 36 pages, 12 figures, accepted by JINST

Published
2010
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40. Study of molecular spin-crossover complex Fe(phen)2(NCS)2 thin films

Author

Shi, Shengwei, Schmerber, G., Arabski, J., Beaufrand, J. -B., Kim, D. J., Boukari, S., Bowen, M., Kemp, N. T., Viart, N., Rogez, G., Beaurepaire, E., Aubriet, H., Petersen, J., Becker, C., and Ruch, D.

Subjects
Condensed Matter - Materials Science
Abstract

We report on the growth by evaporation under high vacuum of high-quality thin films of Fe(phen)2(NCS)2 (phen=1,10-phenanthroline) that maintain the expected electronic structure down to a thickness of 10 nm and that exhibit a temperature-driven spin transition. We have investigated the current-voltage characteristics of a device based on such films. From the space charge-limited current regime, we deduce a mobility of 6.5x10-6 cm2/V?s that is similar to the low-range mobility measured on the widely studied tris(8-hydroxyquinoline)aluminium organic semiconductor. This work paves the way for multifunctional molecular devices based on spin-crossover complexes.

Published
2009
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41. Patterns of Multimorbidity and Differences in Healthcare Utilization and Complexity Among Acutely Hospitalized Medical Patients (≥65 Years) – A Latent Class Approach

Author

Juul-Larsen HG, Christensen LD, Bandholm T, Andersen O, Kallemose T, Jørgensen LM, and Petersen J

Subjects
chronic conditions, multimorbidity, older medical patients, acute hospitalization, latent class analysis, Infectious and parasitic diseases, RC109-216
Abstract

Helle Gybel Juul-Larsen, 1–3 Line Due Christensen, 1, 4 Thomas Bandholm, 1–3, 5 Ove Andersen, 1, 2, 6 Thomas Kallemose, 1 Lillian Mørch Jørgensen, 1, 6 Janne Petersen 1, 7, 8 1Clinical Research Centre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; 3Department of Physical and Occupational Therapy, Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 4Research Unit for General Practice, Aarhus, Denmark; 5Department of Orthopedic Surgery, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 6Emergency Department, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 7Centre for Clinical Research and Prevention, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark; 8Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, DenmarkCorrespondence: Helle Gybel Juul-LarsenClinical Research Centre, Section 056, Copenhagen University, Amager and Hvidovre Hospitals, Kettegård Allé 30, Hvidovre DK-2650, DenmarkTel +45 38626077Email helle.juul-larsen@regionh.dkPurpose: The majority of acutely admitted older medical patients are multimorbid, receive multiple drugs, and experience a complex treatment regime. To be able to optimize treatment and care, we need more knowledge of the association between different patterns of multimorbidity and healthcare utilization and the complexity thereof. The purpose was therefore to investigate patterns of multimorbidity in a Danish national cohort of acutely hospitalized medical patients aged 65 and older and to determine the association between these multimorbid patterns with the healthcare utilization and complexity.Patients and Methods: Longitudinal cohort study of 129,900 (53% women) patients. Latent class analysis (LCA) was used to develop patterns of multimorbidity based on 22 chronic conditions ascertained from Danish national registers. A latent class regression was used to test for differences in healthcare utilization and healthcare complexity among the patterns measured in the year leading up to the index admission.Results: LCA identified eight distinct multimorbid patterns. Patients belonging to multimorbid patterns including the major chronic conditions; diabetes and chronic obstructive pulmonary disease was associated with higher odds of healthcare utilization and complexity than the reference pattern (“Minimal chronic conditions”). The pattern with the highest number of chronic conditions did not show the highest healthcare utilization nor complexity.Conclusion: Our study showed that chronic conditions cluster together and that these patterns differ in healthcare utilization and complexity. Patterns of multimorbidity have the potential to be used in epidemiological studies of healthcare planning but should be confirmed in other population-based studies.Keywords: chronic conditions, multimorbidity, older medical patients, acute hospitalization, latent class analysis

Published
2020

44. Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics

Author

The ATLAS Collaboration, Aad, G., Abat, E., Abbott, B., Abdallah, J., Abdelalim, A. A., Abdesselam, A., Abdinov, O., Abi, B., Abolins, M., Abramowicz, H., Acharya, B. S., Adams, D. L., Addy, T. N., Adorisio, C., Adragna, P., Adye, T., Aguilar-Saavedra, J. A., Aharrouche, M., Ahlen, S. P., Ahles, F., Ahmad, A., Ahmed, H., Aielli, G., Akdogan, T., Akesson, T. P. A., Akimoto, G., Alam, M. S., Alam, M. A., Albert, J., Albrand, S., Aleksa, M., Aleksandrov, I. N., Alessandria, F., Alexa, C., Alexander, G., Alexandre, G., Alexopoulos, T., Alhroob, M., Alimonti, G., Alison, J., Aliyev, M., Allport, P. P., Allwood-Spiers, S. E., Aloisio, A., Alon, R., Alonso, A., Alonso, J., Alviggi, M. G., Amako, K., Amaral, P., Amelung, C., Ammosov, V. V., Amorim, A., Amoros, G., Amram, N., Anastopoulos, C., Anders, C. F., Anderson, K. J., Andreazza, A., Andrei, V., Andrieux, M-L., Anduaga, X. S., Anghinolfi, F., Antonaki, A., Antonelli, M., Antonelli, S., Antunovic, B., Anulli, F. A., Arabidze, G., Aracena, I., Arai, Y., Arce, A. T. H., Archambault, J. P., Arfaoui, S., Arguin, J-F., Argyropoulos, T., Arik, E., Arik, M., Armbruster, A. J., Arnaez, O., Arnault, C., Artamonov, A., Arutinov, D., Asai, M., Asai, S., Ask, S., Asman, B., Asner, D., Asquith, L., Assamagan, K., Astbury, A., Astvatsatourov, A., Atkinson, T., Atoian, G., Auerbach, B., Auge, E., Augsten, K., Aurousseau, M. A., Austin, N., Avolio, G., Avramidou, R., Axen, A., Ay, C., Azuelos, G., Azuma, Y., Baak, M. A., Baccaglioni, G., Bacci, C., Bachacou, H., Bachas, K., Backes, M., Badescu, E., Bagnaia, P., Bai, Y., Bailey, D. C., Baines, J. T., Baker, O. K., Pedrosa, F. Baltasar Dos Santos, Banas, E., Banerjee, S., Banfi, D., Bangert, A., Bansal, V., Baranov, S. P., Baranov, S., Barashkou, A., Barber, T. B., Barberio, E. L., Barberis, D., Barbero, M. B., Bardin, D. Y., Barillari, T., Barisonzi, M., Barklow, T., Barlow, N. B., Barnett, B. M., Barnett, R. M., Baron, S., Baroncelli, A., Barr, A. J., Barreiro, F., da Costa, J. Barreiro Guimaraes, Barrillon, P., Bartoldus, R., Bartsch, D., Bastos, J., Bates, R. L., Batley, J. R., Battaglia, A., Battistin, M., Bauer, F., Bazalova, M., Beare, B., Beauchemin, P. H., Beccherle, R. B., Becerici, N., Bechtle, P., Beck, G. A., Beck, H. P., Beckingham, M., Becks, K. H., Bedajanek, I., Beddall, A. J., Beddall, A., Bednar, P., Bednyakov, V. A., Bee, C., Harpaz, S. Behar, Behera, P. K., Beimforde, M., Belanger-Champagne, C., Bell, P. J., Bell, W. H., Bella, G., Bellagamba, L., Bellina, F., Bellomo, M., Belloni, A., Belotskiy, K., Beltramello, O., Ami, S. Ben, Benary, O., Benchekroun, D., Bendel, M., Benedict, B. H., Benekos, N., Benhammou, Y., Benincasa, G. P., Benjamin, D. P., Benoit, M., Bensinger, J. R., Benslama, K., Bentvelsen, S., Beretta, M., Berge, D., Kuutmann, E. 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O., Degenhardt, J., Dehchar, M., Del Papa, C., Del Peso, J., Del Prete, T., Dell'Acqua, A., Dell'Asta, L., Della Pietra, M., della Volpe, D., Delmastro, M., Delruelle, N., Delsart, P. A., Demers, S., Demichev, M., Demirkoz, B., Deng, W., Denisov, S. P., Dennis, C., Derue, F., Dervan, P., Desch, K. K., Deviveiros, P. O., Dewhurst, A., Dhullipudi, R., Di Ciaccio, A., Di Ciaccio, L., Di Domenico, A., Di Girolamo, A., Di Girolamo, B., Di Luise, S., Di Mattia, A., Di Nardo, R., Di Simone, A., Di Sipio, R., Diaz, M. A., Diehl, E. B., Dietrich, J., Diglio, S., Yagci, K. Dindar, Dingfelder, D. J., Dionisi, C., Dita, P., Dita, S., Dittus, F., Djama, F., Djilkibaev, R., Djobava, T., Vale, M. A. B. do, Dobbs, M., Dobinson, R., Dobos, D., Dobson, E., Dobson, M., Dogan, O. B., Doherty, T., Doi, Y., Dolejsi, J., Dolenc, I., Dolezal, Z., Dolgoshein, B. A., Donega, M., Donini, J., Donszelmann, T., Dopke, J., Dorfan, D. E., Doria, A., Anjos, A. Dos, Dosil, M., Dotti, A., Dova, M. 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T., Todorova-Nova, S., Tojo, J., Tokar, S., Tokushuku, K., Tomasek, L., Tomasek, M., Tomasz, F., Tomoto, M., Tompkins, D., Tompkins, L., Toms, K., Tonazzo, A., Tong, G., Tonoyan, A., Topfel, C., Topilin, N. D., Torrence, E., Pastor, E. Torro, Toth, J., Touchard, F., Tovey, D. R., Tovey, S. N., Trefzger, T., Tremblet, L., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Tripiana, M. F., Triplett, N., Trischuk, W., Trivedi, A., Trocme, B., Troncon, C., Tsarouchas, C., Tseng, J. C-L., Tsiafis, I., Tsiakiris, M., Tsiareshka, P. V., Tsipolitis, G., Tskhadadze, E. G., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Turala, M., Turecek, D., Cakir, I. Turk, Turlay, E., Tuts, P. M., Twomey, M. S., Tyndel, M., Typaldos, D., Tzanakos, G., Ueda, I., Uhrmacher, M., Ukegawa, F., Unal, G., Underwood, D. G., Undrus, A., Unel, G., Unno, Y., Urkovsky, E., Urquijo, P., Urrejola, P., Usai, G., Vacavant, L., Vacek, V., Vachon, B., Vahsen, S., Valderanis, C., Valenta, J., Valente, P., Valkar, S., Ferrer, J. A. Valls, Van der Bij, H., van der Graaf, H., van der Kraaij, E., van der Poel, E., van Eldik, N., van Gemmeren, P., van Kesteren, Z., van Vulpen, I., VanBerg, R., Vandelli, W., Vandoni, G., Vaniachine, A., Vankov, P., Vannucci, F., Rodriguez, F. Varela, Vari, R., Varnes, E. W., Varouchas, D., Vartapetian, A., Varvell, K. E., Vassilakopoulos, V. I., Vassilieva, L., Vataga, E., Vazeille, F., Vegni, G., Veillet, J. J., Vellidis, C., Veloso, F., Veness, R., Veneziano, S., Ventura, A., Ventura, D., Ventura, S., Venturi, N., Vercesi, V., Verducci, M., Verkerke, W., Vermeulen, J. C., Vetterli, M. C., Vichou, I., Vickey, T., Viehhauser, G. H. A., Villa, M., Villani, E. G., Perez, M. Villaplana, Vilucchi, E., Vincter, M. G., Vinogradov, V. B., Virchaux, M., Viret, S., Virzi, J., Vitale, A., Vitells, O. V., Vivarelli, I., Vives, R., Vaques, F. 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V., Zenis, T., Zenonos, Z., Zenz, S., Zerwas, D., Zhan, Z., Zhang, H., Zhang, J., Zhang, Q., Zheng, W., Zhang, X., Zhao, L., Zhao, T., Zhao, Z., Zhelezko, A., Zhemchugov, A., Zheng, S., Zhong, J., Zhou, B., Zhou, N., Zhou, S., Zhou, Y., Zhu, C. G., Zhu, H., Zhu, Y., Zhuang, X. A., Zhuravlov, V., Zilka, B., Zimmermann, R., Zimmermann, S., Zinna, M., Ziolkowski, M., Zitoun, R., Zivkovic, L., Zmouchko, V. V., Zobernig, G., Zoccoli, A., Nedden, M. zur, and Zychacek, V.

Subjects
High Energy Physics - Experiment
Abstract

A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN.

Published
2008

45. On the anomalous red giant branch of the globular cluster Omega Cen

Author

Freyhammer, L. M., Monelli, M., Bono, G., Cunti, P., Ferraro, I., Calamida, A., Degl'Innocenti, S., Moroni, P. G. Prada, Del Principe, M., Piersimoni, A., Iannicola, G., Stetson, P. B., Andersen, M. I., Buonanno, R., Corsi, C. E., Dall'Ora, M., Petersen, J. O., Pulone, L., Sterken, C., and Storm, J.

Subjects
Astrophysics
Abstract

We present three different optical and near-infrared (NIR) data sets for evolved stars in the Galactic Globular Cluster Omega Cen The comparison between observations and homogeneous sets of stellar isochrones and Zero-Age Horizontal Branches provides two reasonable fits. Both of them suggest that the so-called anomalous branch has a metal-intermediate chemical composition (-1.1 < [Fe/H] < -0.8) and is located ~500 pc beyond the bulk of Omega Cen stars. These findings are mainly supported by the shape of the subgiant branch in four different color-magnitude diagrams (CMDs). The most plausible fit requires a higher reddening, E(B-V)=0.155 vs. 0.12, and suggests that the anomalous branch is coeval, within empirical and theoretical uncertainties, to the bulk of Omega Cen stellar populations. This result is supported by the identification of a sample of faint horizontal branch stars that might be connected with the anomalous branch. Circumstantial empirical evidence seems to suggest that the stars in this branch form a clump of stars located beyond the cluster., Comment: Accepted for publication on ApJ. High resolution figures can be downloaded from ftp://ftp.mporzio.astro.it/dist/monelli2/

Published
2005
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47. Proceedings to the Workshops 'What comes beyond the Standard model' 2000,2001, VOLUME 1: Festschrift dedicated to the 60th birthday of Holger Bech Nielsen

Author

Borstnik, N. S. Mankoc, Froggatt, C. D., Lukman, D., Axenides, M., Melikhov, D., Stech, B., Fairlie, D. B., Frampton, P. H., van Holten, J. W., Petersen, J. L., Laperashvili, L. V., Ryzhikh, D. A., Olesen, P., Susskind, L., Blinnikov, S. I., Okun, L. B., Vysotsky, M. I., and Greensite, Jeff

Subjects
High Energy Physics - Phenomenology
Abstract

The present volume is the collection of contributions by friends of Holger Bech Nielsen for his 60th birthday. Contents: 1.Unified internal space of spins and charges (N. Mankoc Borstnik) 2.Semitopological Q-Rings (M. Axenides) 3.Non-local axial anomalies in the Standard model (D. Melikhov, B. Stech) 4.Could there be a fourth generation? (C.D. Froggatt) 5.Another complex Bateman equation (D.B. Fairlie) 6.Non-associative loops for Holger Bech Nielsen (P.H. Frampton) 7.Particles, fluids and vortices (J.W. van Holten) 8.Results on 2D current algebras (J.L. Petersen) 9.Phase transition in gauge theories and the Planck scale physics (L.V. Laperashvili and D.A. Ryzhikh) 10.Some remarks on the 'classical' large N limit (P. Olesen) 11.String theory and the size of hadrons (L. Susskind) 12.Relativity and $c/sqrt3$ (S.I. Blinnikov, L.B. Okun and M.I. Vysotsky) 13.Vortices (Jeff Greensite), Comment: The proceedings includes 13 papers of different authors. Editors were N. S. Mankoc Borstnik, C. D. Froggatt, D. Lukman

Published
2002

48. Social marketing and public health

Author

Petersen, J.

Subjects
550
Abstract

The public health field exists to safeguard the general public from health risks by controlling risk factors, classically through immunization programmes that prevent or control epidemics, or through actions such as monitoring the quality of drinking water. In our post-industrialised society, risk factors other than the environment, such as diet, exercise, tobacco and alcohol use, have grown in importance. The policy response to the growing demand upon healthcare services arising from chronic diseases caused by changing lifestyle factors has taking different forms, and these include targeting vulnerable groups using health promoting campaigns. This thesis addresses some of the challenges and opportunities in public health campaigns and healthcare planning that arise from the growing repositories of data that can be made available for targeting at the individual and small area level in a public health setting. The first part sets the scene by describing the concepts of health, public health and social marketing. The intention is to pave the way for broader discussions – in the progress of the thesis – about healthcare planning, population health, and social processes in the light of targeted public health interventions. Part two addresses the problems and possible solutions to a number issues in healthcare planning, starting with studies at the individual, then moving to organisations and ending with area classifications. The thesis draws on a number of case studies for targeting in a public health context including frequent accident and emergency users, teenage users of abortion services, women’s breast screening uptake, GP registration, and the neighbourhood characteristics of chronic disease patients. Finally, part three provides a synopsis of both context (part one), results (part two) and future perspectives on how routinely collected healthcare data can be used to create evidence for the planning of new cost-effective interventions.

Published
2009

49. SX Phoenicis Stars in the Core of 47 Tucanae

Author

Bruntt, H., Frandsen, S., Gilliland, R. L., Christensen-Dalsgaard, J., Petersen, J. O., Guhathakurta, P., Edmonds, P. D., and Bono, G.

Subjects
Astrophysics
Abstract

We present new results on five of six known SX Phoenicis stars in the core of the globular cluster 47 Tucanae. We give interpretations of the light curves in the V and I bands from 8.3 days of observations with the Hubble Space Telescope near the core of 47 Tuc. The most evolved SX Phe star in the cluster is a double-mode pulsator (V2) and we determine its mass to be 1.54+/-0.05 solar masses from its position in the Hertzsprung-Russell diagram and by comparing observed periods with current theoretical pulsation models. For V14 we do not detect any pulsation signal. For the double-mode pulsators V3, V15, and V16 we cannot give a safe identification of the modes. We also describe the photometric techniques we have used to extract the light curves of stars in the crowded core. Some of the SX Phoenicis are saturated and we demonstrate that even for stars that show signs of a bleeding signal we can obtain a point-to-point accuracy of 1-3%., Comment: 13 pages, 12 figures, accepted for publication in A&A (2001)

Published
2001
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50. JBEI Electronic Laboratory Notebook System

Author

Pletcher, D., Gladden, John M., Holmes, B. M., Keasling, Jay D., Lane, S., Morrell, W., Panganiban, A. Herrera, Petersen, J., Townsend-Merino, F. W., Wildman, J., and Adams, Paul D.

Published
2009

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