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6. mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RAint TEMRA-like CD8+ T cells in COVID-19 recovered individuals

Author

Mayer-Blackwell, Koshlan, primary, Ryu, Heeju, additional, Codd, Amy S., additional, Parks, K. Rachael, additional, MacMillan, Hugh R., additional, Cohen, Kristen W., additional, Stewart, Terri L., additional, Seese, Aaron, additional, Lemos, Maria P., additional, De Rosa, Stephen C., additional, Czartoski, Julie L., additional, Moodie, Zoe, additional, Nguyen, Long T., additional, McGuire, Donald J., additional, Ahmed, Rafi, additional, Fiore-Gartland, Andrew, additional, McElrath, M. Juliana, additional, and Newell, Evan W., additional

Published
2023
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10. Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

Author

Seydoux, Emilie, Homad, Leah J., MacCamy, Anna J., Parks, K. Rachael, Hurlburt, Nicholas K., Jennewein, Madeleine F., Akins, Nicholas R., Stuart, Andrew B., Wan, Yu-Hsin, Feng, Junli, Whaley, Rachael E., Singh, Suruchi, Boeckh, Michael, Cohen, Kristen W., McElrath, M. Juliana, Englund, Janet A., Chu, Helen Y., Pancera, Marie, McGuire, Andrew T., and Stamatatos, Leonidas

Published
2020
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15. Many Labs 5: Registered Replication Report of Payne, Burkley, & Stokes (2008), Study 4

Author

Ebersole, C, Andrighetto, L, Casini, E, Chiorri, C, Dalla Rosa, A, Domaneschi, F, Ferguson, I, Fryberger, E, Giacomantonio, M, Grahe, J, Joy-Gaba, J, Langford, E, Nichols, A, Panno, A, Parks, K, Preti, E, Richetin, J, Vianello, M, Ebersole, CR, Langford, EV, Nichols, AL, Parks, KP, Ebersole, C, Andrighetto, L, Casini, E, Chiorri, C, Dalla Rosa, A, Domaneschi, F, Ferguson, I, Fryberger, E, Giacomantonio, M, Grahe, J, Joy-Gaba, J, Langford, E, Nichols, A, Panno, A, Parks, K, Preti, E, Richetin, J, Vianello, M, Ebersole, CR, Langford, EV, Nichols, AL, and Parks, KP

Abstract

To rule out an alternative to their structural-fit hypothesis, Payne, Burkley, and Stokes (2008) demonstrated that correlations between implicit and explicit race attitudes were weaker when participants were put under high pressure to respond without bias than when they were placed under low pressure. This effect was replicated in Italy by Vianello (2015), although the replication effect was smaller than the original effect. In the current investigation, we examined the possibility that the source of a study’s sample moderates this effect. Teams from eight universities, four in the United States and four in Italy, replicated the original study (replication N = 1,103). Although we did detect moderation by the sample’s country, it was due to a reversal of the original effect in the United States and a lack of the original effect in Italy. We discuss this curious finding and possible explanations.

Published
2020

16. Genomic instability in human lymphoid cells exposed to 1 GeV/amu Fe ions

Author

Grosovsky, A, Bethel, H, Parks, K, Ritter, L, Giver, C, Gauny, S, Wiese, C, and Kronenberg, A

Subjects
Life Sciences (General)
Abstract

The goal of this study was to assess whether charged particle radiations of importance to spaceflight elicit genomic instability in human TK6 lymphoblasts. The incidence of genomic instability in TK6 cells was assessed ~21 days after exposure to 2, 4, or 6 Fe ions (1 GeV/amu, LET= 146 keV/micrometers). Three indices of instability were used: intraclonal karyotypic heterogeneity, mutation rate analysis at the thymidine kinase (TK1) locus, and re-cloning efficiency. Fifteen of sixty clones demonstrated karyotypic heterogeneity. Five clones had multiple indicators of karyotypic change. One clone was markedly hypomutable and polyploid. Six clones were hypomutable, while 21 clones were mutators. Of these, seven were karyotypically unstable. Six clones had low re-cloning efficiencies, one of which was a mutator. All had normal karyotypes. In summary, many clones that survived exposure to a low fluence of Fe ions manifested one or more forms of genomic instability that may hasten the development of neoplasia through deletion or by recombination.

Published
2001

17. Anti-idiotypic antibodies elicit anti-HIV-1–specific B cell responses

Author

Dosenovic, Pia, primary, Pettersson, Anna-Klara, additional, Wall, Abigail, additional, Thientosapol, Eddy S., additional, Feng, Junli, additional, Weidle, Connor, additional, Bhullar, Komal, additional, Kara, Ervin E., additional, Hartweger, Harald, additional, Pai, Joy A., additional, Gray, Matthew D., additional, Parks, K. Rachael, additional, Taylor, Justin J., additional, Pancera, Marie, additional, Stamatatos, Leonidas, additional, Nussenzweig, Michel C., additional, and McGuire, Andrew T., additional

Published
2019
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19. mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RAintTEMRA-like CD8+T cells in COVID-19 recovered individuals

Author

Mayer-Blackwell, Koshlan, Ryu, Heeju, Codd, Amy S., Parks, K. Rachael, MacMillan, Hugh R., Cohen, Kristen W., Stewart, Terri L., Seese, Aaron, Lemos, Maria P., De Rosa, Stephen C., Czartoski, Julie L., Moodie, Zoe, Nguyen, Long T., McGuire, Donald J., Ahmed, Rafi, Fiore-Gartland, Andrew, McElrath, M. Juliana, and Newell, Evan W.

Abstract

SARS-CoV-2 infection and mRNA vaccination both elicit spike (S)-specific T cell responses. To analyze how T cell memory from prior infection influences T cell responses to vaccination, we evaluated functional T cell responses in naive and previously infected vaccine recipients. Pre-vaccine S-specific responses are predictive of subsequent CD8+T cell vaccine-response magnitudes. Comparing baseline with post-vaccination TCRβ repertoires, we observed large clonotypic expansions correlated with the frequency of spike-specific T cells. Epitope mapping the largest CD8+T cell responses confirms that an HLA-A∗03:01 epitope was highly immunodominant. Peptide-MHC tetramer staining together with mass cytometry and single-cell sequencing permit detailed phenotyping and clonotypic tracking of these S-specific CD8+T cells. Our results demonstrate that infection-induced S-specific CD8+T cell memory plays a significant role in shaping the magnitude and clonal composition of the circulating T cell repertoire after vaccination, with mRNA vaccination promoting CD8+memory T cells to a TEMRA-like phenotype.

Published
2023
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23. Multidisciplinary care of patients receiving cardiac resynchronization therapy is associated with improved clinical outcomes

Author

Altman, R. K., primary, Parks, K. A., additional, Schlett, C. L., additional, Orencole, M., additional, Park, M.-Y., additional, Truong, Q. A., additional, Deeprasertkul, P., additional, Moore, S. A., additional, Barrett, C. D., additional, Lewis, G. D., additional, Das, S., additional, Upadhyay, G. A., additional, Heist, E. K., additional, Picard, M. H., additional, and Singh, J. P., additional

Published
2012
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25. Poster Session 2

Author

Andersson, T., primary, Magnusson, A., additional, Bryngelsson, I.- L., additional, Frobert, O., additional, Henriksson, K. M., additional, Edvardsson, N., additional, Poci, D., additional, Polovina, M., additional, Potpara, T., additional, Licina, M., additional, Mujovic, N., additional, Kocijancic, A., additional, Simic, D., additional, Ostojic, M. C., additional, Providencia, R. A., additional, Botelho, A., additional, Trigo, J., additional, Nascimento, J., additional, Quintal, N., additional, Mota, P., additional, Leitao-Marques, A. M., additional, Bosch, R. F., additional, Kirch, W., additional, Rosin, L., additional, Willich, S. N., additional, Pittrow, D., additional, Bonnemeier, H., additional, Valenza, M. C., additional, Martin, L., additional, Munoz Casaubon, T., additional, Valenza, G., additional, Botella, M., additional, Serrano, M., additional, Valenza, B., additional, Cabrera, I., additional, Anderson, K., additional, Benzaquen, B. S., additional, Koziolova, N., additional, Nikonova, J., additional, Shilova, Y., additional, Scherr, D., additional, Narayan, S., additional, Wright, M., additional, Krummen, D., additional, Jadidi, A., additional, Jais, P., additional, Haissaguerre, M., additional, Hocini, M., additional, Hunter, R., additional, Liu, Y., additional, Lu, Y., additional, Wang, W., additional, Schilling, R. J., additional, Bernstein, S., additional, Wong, B., additional, Rooke, R., additional, Vasquez, C., additional, Shah, R., additional, Rosenberg, S., additional, Chinitz, L., additional, Morley, G., additional, Bashir Choudhary, M., additional, Holmqvist, F., additional, Carlson, J., additional, Nilsson, H.- J., additional, Platonov, P. G., additional, Jadidi, A. S., additional, Cochet, H., additional, Miyazaki, S., additional, Shah, A. J., additional, Marrouche, N., additional, Calvo, N., additional, Nadal, M., additional, Andreu, D., additional, Tamborero, D., additional, Diaz, F. E., additional, Berruezo, A., additional, Brugada, J., additional, Mont, L., additional, Fichtner, S., additional, Hessling, G., additional, Estner, H. L., additional, Jilek, C., additional, Reents, T., additional, Ammar, S., additional, Wu, J., additional, Deisenhofer, I., additional, Nakanishi, H., additional, Kashiwase, K., additional, Hirata, A., additional, Wada, M., additional, Ueda, Y., additional, Skoda, J., additional, Neuzil, P., additional, Popelova, J., additional, Petru, J., additional, Sediva, L., additional, Reddy, V. Y., additional, Uldry, L., additional, Forclaz, A., additional, Virag, N., additional, Vesin, J.- M., additional, Kappenberger, L., additional, Sehra, R., additional, Briggs, C., additional, Rappel, W.- J., additional, Janotka, M., additional, Chovanec, M., additional, Yamashiro, K., additional, Takami, K., additional, Sakamoto, Y., additional, Satoh, K., additional, Suzuki, T., additional, Nakagawa, H., additional, Romanov, A., additional, Pokushalov, E., additional, Artemenko, S., additional, Shabanov, V., additional, Stenin, I., additional, Elesin, D., additional, Turov, A., additional, Yakubov, A., additional, Hioki, M., additional, Matsuo, S., additional, Ito, K., additional, Narui, R., additional, Yamashita, S., additional, Sugimoto, K., additional, Yoshimura, M., additional, Yamane, T., additional, Di Biase, L., additional, Gallinghouse, J. D., additional, Rajappan, K., additional, Kautzner, J., additional, Dello Russo, A., additional, Tondo, C., additional, Lorgat, F., additional, Natale, A., additional, Balta, O., additional, Buenz, K., additional, Paessler, M., additional, Anders, H., additional, Horlitz, M., additional, Deneke, T., additional, Lickfett, L., additional, Liberman, I., additional, Linhart, M., additional, Andrie, R., additional, Mittmann-Braun, E., additional, Stockigt, F., additional, Nickenig, G., additional, Schrickel, J., additional, Tilz, R., additional, Rillig, A., additional, Feige, B., additional, Metzner, A., additional, Fuernkranz, A., additional, Burchard, A., additional, Wissner, E., additional, Ouyang, F., additional, Betts, T. R., additional, Jones, M. A., additional, Wong, K. C. K., additional, Qureshi, N., additional, Bashir, Y., additional, Corbucci, G., additional, Losik, D., additional, Selina, V., additional, Crandall, M. A., additional, Daniels, C., additional, Daoud, E., additional, Kalbfleisch, S., additional, Yamaji, H., additional, Murakami, T., additional, Kawamura, H., additional, Murakami, M., additional, Hina, K., additional, Kusachi, S., additional, Dakos, G., additional, Vassilikos, V., additional, Paraskevaidis, S., additional, Mantziari, A., additional, Theophylogiannakos, S., additional, Chouvarda, I., additional, Chatzizisis, I., additional, Styliadis, I., additional, Kimura, T., additional, Fukumoto, K., additional, Nishiyama, N., additional, Aizawa, Y., additional, Fukuda, Y., additional, Sato, T., additional, Miyoshi, S., additional, Takatsuki, S., additional, Navarrete Casas, A. J., additional, Ali, I., additional, Conte, F. C., additional, Moran, M., additional, Graham, B. G., additional, Kalejs, O., additional, Lacis, R., additional, Stradins, P., additional, Koris, A., additional, Putnins, I., additional, Vikmane, M., additional, Lejnieks, A., additional, Erglis, A., additional, Estrada, A., additional, Perez Silva, A., additional, Castrejon, S., additional, Doiny, D., additional, Merino, J. L., additional, Baranchuk, A., additional, Greiss, I., additional, Simpson, C. S., additional, Abdollah, H., additional, Redfearn, D. P., additional, Buys-Topart, M., additional, Nitzsche, R., additional, Thibault, B., additional, Kathan, S., additional, Kolb, C., additional, Reif, S., additional, Schade, S., additional, Taggeselle, J., additional, Frey, A., additional, Birkenhagen, A., additional, Kohler, S., additional, Schmidt, M., additional, Cano Perez, O., additional, Buendia, F., additional, Igual, B., additional, Osca, J. M., additional, Sanchez, J. M., additional, Sancho-Tello, M. J., additional, Olague, J. M., additional, Salvador, A., additional, Tolosana, J. M., additional, Fernandez-Armenta, J., additional, Matas, M., additional, Barbarin, M. C., additional, Habibovic, M., additional, Van Den Broek, K. C., additional, Theuns, D. A. M. J., additional, Jordaens, L., additional, Alings, M., additional, Van Der Voort, P. H., additional, Pedersen, S. S., additional, Pupita, G., additional, Molini, S., additional, Brambatti, M., additional, Capucci, A., additional, Molodykh, S., additional, Idov, E. M., additional, Belyaev, O. V., additional, Segreti, L., additional, Soldati, E., additional, Zucchelli, G., additional, Di Cori, A., additional, Viani, S., additional, Paperini, L., additional, De Lucia, R., additional, Bongiorni, M. G., additional, Binner, L., additional, Taborsky, M., additional, Bello, D., additional, Heuer, H., additional, Ramza, B., additional, Jenniskens, I., additional, Johnson, W. B., additional, Silvetti, M. S., additional, Rava', L., additional, Russo, M. S., additional, Di Mambro, C., additional, Ammirati, A., additional, Gimigliano, G., additional, Prosperi, M., additional, Drago, F., additional, Santos, A. R., additional, Picarra, B., additional, Semedo, P., additional, Dionisio, P., additional, Matos, R., additional, Leitao, M., additional, Jacinto, A., additional, Trinca, M., additional, Mazzone, P., additional, Ciconte, G., additional, Marzi, A., additional, Paglino, G., additional, Vergara, P., additional, Sora, N., additional, Gulletta, S., additional, Della Bella, P., additional, Koppitz, P., additional, Fach, A., additional, Hobbiesiefken, S., additional, Fiehn, E., additional, Hambrecht, R., additional, Sperzel, J., additional, Jung, M., additional, Schmitt, J., additional, Pajitnev, D., additional, Burger, H., additional, Goebel, G., additional, Ehrlich, W., additional, Walther, T., additional, Ziegelhoeffer, T., additional, Vancura, V., additional, Wichterle, D., additional, Melenovsky, V., additional, Glikson, M., additional, Goldenberg, G., additional, Segev, A., additional, Dvir, D., additional, Kuzniec, J., additional, Finkelstein, A., additional, Hay, I., additional, Guetta, V., additional, Choo, W. K., additional, Gupta, S., additional, Kirkfeldt, R., additional, Johansen, J., additional, Nohr, E., additional, Moller, M., additional, Arnsbo, P., additional, Nielsen, J., additional, Banha, M., additional, Stojanov, P., additional, Raspopovic, S., additional, Vasic, D., additional, Savic, D., additional, Nikcevic, G., additional, Jovanovic, V., additional, Defaye, P., additional, Mondesert, B., additional, Mbaye, A., additional, Cassagneau, R., additional, Gagniere, V., additional, Jacon, J., additional, Sanfins, V., additional, Reis, H. R., additional, Nobre, J. N., additional, Martins, V. M., additional, Duarte, L. D., additional, Morais, C. M., additional, Conceicao, J. C., additional, Hero, M., additional, Rey, J. L., additional, Ducharme, A., additional, Simpson, C., additional, Stuglin, C., additional, Blier, L., additional, Senaratne, M., additional, Khaykin, Y., additional, Pinter, A., additional, Mlynarska, A., additional, Mlynarski, R., additional, Sosnowski, M., additional, Wilczek, J., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Dorobantu, M., additional, Radu, A., additional, Vatasescu, R.- G., additional, Yusu, S., additional, Ikeda, T., additional, Mera, H., additional, Miwa, Y., additional, Abe, A., additional, Miyakoshi, M., additional, Tsukada, T., additional, Yoshino, H., additional, Nayar, V., additional, Cantelon, P., additional, Rawling, A., additional, Belham, M. R. D., additional, Pugh, P. J., additional, Osca Asensi, J., additional, Cano, O., additional, Tejada, D., additional, Munoz, B., additional, Rodriguez, M., additional, Olague, J., additional, Wecke, L., additional, Van Hunnik, A., additional, Thompson, T., additional, Di Carlo, L., additional, Zdeblick, M., additional, Auricchio, A., additional, Prinzen, F., additional, Doltra Magarolas, A., additional, Bijnens, B., additional, Silva, E., additional, Penela, D., additional, Sitges, M., additional, Ofman, P., additional, Navaravong, L., additional, Leng, J., additional, Peralta, A., additional, Hoffmeister, P., additional, Levine, R., additional, Cook, J., additional, Stoenescu, M., additional, Tettamanti, M. E., additional, Revilla Orodea, A., additional, Lopez Diaz, J., additional, De La Fuente Galan, L., additional, Arnold, R., additional, Garcia Moran, E., additional, San Roman Calvar, J. A., additional, Gomez Salvador, I., additional, Nakamura, K., additional, Takami, M., additional, Keida, T., additional, Mesato, A., additional, Higa, S., additional, Shimabukuro, M., additional, Masuzaki, H., additional, Proietti, R., additional, Sagone, A., additional, Domenichini, G., additional, Burri, H., additional, Valzania, C., additional, Biffi, M., additional, Sunthorn, H., additional, Gavaruzzi, G., additional, Foulkes, H., additional, Boriani, G., additional, Koh, S., additional, Hou, W., additional, Snell, J., additional, Poore, J., additional, Dalal, N., additional, Bornzin, G., additional, Kloppe, A., additional, Mijic, D., additional, Bogossian, H., additional, Ninios, I., additional, Zarse, M., additional, Lemke, B., additional, Guedon-Moreau, L., additional, Kouakam, C., additional, Klug, D., additional, Marquie, C., additional, Ziglio, F., additional, Kacet, S., additional, Mohamed Fereig Hamed, H., additional, Hamdy, A. M. A. L., additional, Abd El Aziz, A. H. M. E. D., additional, Nabih, M. R. V. A. T., additional, Hamdy, R. E. H. A. B., additional, Yaminisaharif, A., additional, Davoudi, G. H., additional, Kasemisaeid, A., additional, Sadeghian, S., additional, Vasheghani Farahani, A., additional, Yazdanifard, P., additional, Shafiee, A., additional, Alonso, C., additional, Grimard, C., additional, Jauvert, G., additional, Lazarus, A., additional, Mont, L. L., additional, Ortiz-Perez, J., additional, Caralt, T., additional, Escudero, J., additional, Perez, F., additional, Griffith, K. M., additional, Ferreyra, R., additional, Urena, P., additional, Demas, M., additional, Muratore, C., additional, Mazzetti, H., additional, Guardado, J., additional, Fernandes, M., additional, Pereira, V. H., additional, Canario-Almeida, F., additional, Ferreira, F., additional, Rodrigues, B., additional, Almeida, J., additional, Sokal, A., additional, Jedrzejczyk, E., additional, Lenarczyk, R., additional, Pluta, S., additional, Kowalski, O., additional, Pruszkowska, P., additional, Swiatkowski, A., additional, Kalarus, Z., additional, Heinke, M., additional, Ismer, B., additional, Kuehnert, H., additional, Heinke, T., additional, Surber, R., additional, Osypka, N., additional, Prochnau, D., additional, Figulla, H. R., additional, Iacopino, S., additional, Landolina, M., additional, Proclemer, A., additional, Padeletti, L., additional, Calvi, V., additional, Pierantozzi, A., additional, Di Stefano, P., additional, Bauer, A., additional, Bode, F., additional, Le Gal, F., additional, Deharo, J. C., additional, Delay, M., additional, Clementy, J., additional, Kawamura, M., additional, Munetsugu, Y., additional, Tanno, K., additional, Kobayashi, Y., additional, Cannom, D., additional, Hosoda, J., additional, Ishikawa, T., additional, Andoh, K., additional, Nobuyoshi, M., additional, Fujii, S., additional, Shizuta, S., additional, Isshiki, T., additional, Castel, M. A., additional, Perez-Villa, F., additional, Vidal, B., additional, Pruszkowska-Skrzep, P., additional, Szulik, M., additional, Kukulski, T., additional, Gianfranchi, L., additional, Bettiol, K., additional, Pacchioni, F., additional, Alboni, P., additional, Abu Sham'a, R., additional, Buber, J., additional, Nof, E., additional, Kuperstein, R., additional, Feinberg, M., additional, Luria, D., additional, Eldar, M., additional, Parks, K., additional, Stone, J. R., additional, Singh, J. P., additional, Hatzinikolaou-Kotsakou, E., additional, Kotsakou, M., additional, Beleveslis, T. H., additional, Moschos, G., additional, Reppas, E., additional, Latsios, P., additional, Tsakiridis, K., additional, Kazemisaeid, A., additional, Davoodi, G., additional, Yamini Sharif, A., additional, Sheikhvatan, M., additional, Toniolo, M., additional, Zanotto, G., additional, Rossi, A., additional, Tomasi, L., additional, Vassanelli, C., additional, Versteeg, H., additional, Mommersteeg, P. M. C., additional, Vergara, G., additional, Blauer, J., additional, Ranjan, R., additional, Vijayakumar, S., additional, Kholmovski, E., additional, Volland, N., additional, Macleod, R., additional, Aguinaga Arrascue, L. E., additional, Bravo, A., additional, Garcia Freire, P., additional, Gallardo, P., additional, Hasbani, E., additional, Dantur, J., additional, Quintana, R., additional, Adragao, P. P., additional, Cavaco, D., additional, Parreira, L., additional, Reis Santos, K., additional, Carmo, P., additional, Miranda, R., additional, Marcelino, S., additional, Cabrita, D., additional, Sommer, P., additional, Gaspar, T., additional, Rolf, S., additional, Arya, A., additional, Piorkowski, C., additional, Hindricks, G., additional, Valles Gras, E., additional, Bazan, V., additional, Portillo, L., additional, Suarez, F., additional, Bruguera, J., additional, Marti, J., additional, Huo, Y., additional, Richter, S., additional, Schoenbauer, R., additional, Rivas, N., additional, Casaldaliga, J., additional, Roca, I., additional, Dos, L., additional, Perez-Rodon, J., additional, Pijuan, A., additional, Garcia-Dorado, D., additional, Moya, A., additional, Carter, H. B., additional, Garg, A., additional, Hegrenes, J., additional, Sih, H. J., additional, Teplitsky, L. R., additional, Kuroki, K., additional, Tada, H., additional, Seo, Y., additional, Ishizu, T., additional, Igawa, M., additional, Sekiguchi, Y., additional, Kuga, K., additional, Aonuma, K., additional, Rodriguez A, C., additional, Mejias, J., additional, Hidalgo, P., additional, Hidalgo L, J. A., additional, Orczykowski, M., additional, Derejko, P., additional, Walczak, F., additional, Szufladowicz, E., additional, Urbanek, P., additional, Bodalski, R., additional, Bieganowska, K., additional, Szumowski, L., additional, Peichl, P., additional, Cihak, R., additional, Skalsky, I., additional, Kubus, P., additional, Vit, P., additional, Zaoral, L., additional, Gebauer, R. A., additional, Fiala, M., additional, Janousek, J., additional, Hiroshima, K., additional, Goya, M., additional, Ohe, M., additional, Hayashi, K., additional, Makihara, Y., additional, Nagashima, M., additional, An, Y., additional, Schloesser, M., additional, Lawrenz, T., additional, Meyer Zu Vilsendorf, D., additional, Strunk-Mueller, C., additional, Stellbrink, C., additional, Papagiannis, J., additional, Avramidis, D., additional, Kokkinakis, C., additional, Kirvassilis, G., additional, Eidelman, G., additional, Arenal, A., additional, Datino, T., additional, Atienza, F., additional, Gonzalez Torrecilla, E., additional, Miracle, A., additional, Hernandez, J., additional, Fernandez Aviles, F., additional, Ene, E., additional, Insulander, P., additional, Bastani, H., additional, Braunschweig, F., additional, Drca, N., additional, Kenneback, G., additional, Schwieler, J., additional, Tapanainen, J., additional, Jensen-Urstad, M., additional, Andrea, B., additional, Andrea, E. M. A., additional, Maciel, W. M., additional, Siqueira, L. S., additional, Cosenza, R. C., additional, Mittidieri, F. M., additional, Farah, S. F., additional, Atie, J. A., additional, Kanoupakis, E., additional, Kallergis, E., additional, Mavrakis, H., additional, Goudis, C., additional, Saloustros, I., additional, Malliaraki, N., additional, Chlouverakis, G., additional, Vardas, P., additional, Bonnes, J. L., additional, Jaspers Focks, J., additional, Westra, S. W., additional, Brouwer, M. A., additional, Smeets, J. L. R. M., additional, Inama, G., additional, Pedrinazzi, C., additional, Oliva, F., additional, Senni, M., additional, Zoni Berisso, M., additional, Mostov, S., additional, Haim, M., additional, Nevzorov, R., additional, Hasadi, D., additional, Starsberg, B., additional, Porter, A., additional, Kuschyk, J., additional, Schoene, A., additional, Streitner, F., additional, Veltmann, C. G., additional, Schimpf, R., additional, Borggrefe, M., additional, Luesebrink, U., additional, Gardiwal, A., additional, Oswald, H., additional, Koenig, T., additional, Duncker, D., additional, Klein, G., additional, Bastiaenen, R., additional, Batchvarov, V., additional, Atty, O., additional, Cheng, J. H., additional, Behr, E. R., additional, Gallagher, M. M., additional, Starrenburg, A. H., additional, Kraaier, K., additional, Scholten, M. F., additional, Van Der Palen, J., additional, Adhya, S., additional, Smith, L. A., additional, Zhao, T., additional, Bannister, C., additional, Kamdar, R. H., additional, Martinelli, M., additional, Siqueira, S., additional, Greco, R., additional, Nishioka, S. A. D., additional, Pedrosa, A. A. A., additional, Alkmim-Teixeira, R., additional, Peixoto, G. L., additional, Costa, R., additional, Nielsen, J. C., additional, Mortensen, P. T., additional, Johansen, J. B., additional, Kwasniewski, W., additional, Filipecki, A., additional, Urbanczyk-Swic, D., additional, Orszulak, W., additional, Trusz - Gluza, M., additional, Jimenez-Candil, J., additional, Morinigo, J., additional, Ledesma, C., additional, Martin-Luengo, C., additional, Vogtmann, T., additional, Gomer, M., additional, Stiller, S., additional, Kuehlkamp, V., additional, Zach, G., additional, Loescher, S., additional, Kespohl, S., additional, Baumann, G., additional, Snell, J. D., additional, Korsun, N., additional, Snell, J. R., additional, Morley, B., additional, Bharmi, R., additional, Nabutovsky, Y., additional, Mollerus, M., additional, Naslund, L., additional, Meyer, A., additional, Lipinski, M., additional, Libey, B., additional, Dornfeld, K., additional, Martin, A., additional, Gallego, M., additional, De Bie, M. K., additional, Van Rees, J. B., additional, Borleffs, C. J., additional, Thijssen, J., additional, Jukema, J. W., additional, Schalij, M. J., additional, Van Erven, L., additional, Van Der Velde, E. T., additional, Witteman, T. A., additional, Foeken, H., additional, Szili-Torok, T., additional, Akca, F., additional, Caliskan, K., additional, Ten Cate, F., additional, Michels, M., additional, Cozma, D. C., additional, Petrescu, L., additional, Mornos, C., additional, Dragulescu, S. I., additional, Groeneweg, J. A., additional, Velthuis, B. K., additional, Cox, M. G. P. J., additional, Loh, P., additional, Dooijes, D., additional, Cramer, M. J., additional, De Bakker, J. M. T., additional, Hauer, R. N. W., additional, Park, S. D., additional, Shin, S. H., additional, Woo, S. I., additional, Kwan, J., additional, Park, K. S., additional, Kim, D. H., additional, Iorio, A., additional, Vitali Serdoz, L., additional, Brun, F., additional, Daleffe, E., additional, Zecchin, M., additional, Dal Ferro, M., additional, Santangelo, S., additional, Sinagra, G. F., additional, Ouali, S., additional, Hammemi, R., additional, Hammas, S., additional, Kacem, S., additional, Gribaa, R., additional, Neffeti, E., additional, Remedi, F., additional, Boughzela, E., additional, Korantzopoulos, P., additional, Letsas, K., additional, Christogiannis, Z., additional, Kalantzi, K., additional, Ntorkos, A., additional, Goudevenos, J., additional, Foley, P. W. X., additional, Yung, L., additional, Barnes, E., additional, Kikuchi, M., additional, Ito, H., additional, Miyoshi, F., additional, Pecini, R., additional, Marott, J. M., additional, Jensen, G. B., additional, Theilade, J., additional, Mine, T., additional, Kodani, T., additional, Masuyama, T., additional, Mozos, I. M., additional, Serban, C., additional, Costea, C., additional, Susan, L., additional, Barthel, P., additional, Mueller, A., additional, Malik, M., additional, Schmidt, G., additional, Karakurt, O., additional, Kilic, H., additional, Munevver Sari, D. R., additional, Mroczek-Czernecka, D., additional, Pietrucha, A. Z., additional, Borowiec, A., additional, Wnuk, M., additional, Bzukala, I., additional, Kruszelnicka, O., additional, Konduracka, E., additional, Nessler, J., additional, Kikuchi, Y., additional, Meireles, A., additional, Gomes, C., additional, Anjo, D., additional, Roque, C., additional, Pinheiro Vieira, A., additional, Lagarto, V., additional, Hipolito Reis, A., additional, Torres, S., additional, Miller, L., additional, Vedrenne, G., additional, Bruguiere, E., additional, Redheuil, A., additional, Lavergne, T., additional, Le Heuzey, J. Y., additional, Mousseaux, E., additional, Hersi, A., additional, Alhabib, K., additional, Alfaleh, H., additional, Sulaiman, K., additional, Almahmeed, W., additional, Alsuwidi, J., additional, Amin, H., additional, Almotarreb, A., additional, Pang, H. W. K., additional, Michael, K., additional, Pereira, E. J., additional, Munt, P. W., additional, Fitzpatrick, M. F., additional, Revishvili, A. S., additional, Simonyan, G., additional, Dzhordzhikiya, T., additional, Sopov, O., additional, Kalinin, V., additional, Locati, E. T., additional, Vecchi, A. M., additional, Cattafi, G., additional, Sachero, A., additional, Lunati, M., additional, Sayah, S., additional, Alizadeh, A., additional, Nazari, N., additional, Hekmat, M., additional, Moradi, M., additional, Zeighami, M., additional, Ghanji, H., additional, Suzuki, K., additional, Takagi, M., additional, Maeda, K., additional, Tatsumi, H., additional, Vieira, P., additional, Reis, H., additional, Toth, A., additional, Vago, H., additional, Takacs, P., additional, Edes, E., additional, Marki, A., additional, Balazs, G. Y., additional, Huttl, K., additional, Merkely, B., additional, Lainis, F., additional, Buckley, M. M., additional, Johns, E. J., additional, Seifer, C. M., additional, Daba, L., additional, Liebrecht, K., additional, Piwowarska, W., additional, Toquero Ramos, J., additional, Perez Pereira, E., additional, Mitroi, C., additional, Castro Urda, V., additional, Fernandez Villanueva, J. M., additional, Corona Figueroa, A., additional, Hernandez Reina, L., additional, Fernandez Lozano, I., additional, Bartoletti, A., additional, Bocconcelli, P., additional, Giuli, S., additional, Massa, R., additional, Svetlich, C., additional, Tarsi, G., additional, Tronconi, F., additional, Vitale, E., additional, Stryjewski, P., additional, Wegrzynowska, M., additional, Lousinha, A., additional, Labandeiro, J., additional, Antunes, E., additional, Silva, S., additional, Alves, S., additional, Timoteo, A., additional, Oliveira, M., additional, Cruz Ferreira, R., additional, and Jedrzejczyk-Spaho, J., additional

Published
2011
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28. Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability

Author

Grosovsky, A J, Parks, K K, Giver, C R, and Nelson, S L

Abstract

Many tumors exhibit extensive chromosomal instability, but karyotypic alterations will be significant in carcinogenesis only by influencing specific oncogenes or tumor suppressor loci within the affected chromosomal segments. In this investigation, the specificity of chromosomal rearrangements attributable to radiation-induced genomic instability is detailed, and a qualitative and quantitative correspondence with mutagenesis is demonstrated. Chromosomal abnormalities preferentially occurred near the site of prior rearrangements, resulting in complex abnormalities, or near the centromere, resulting in deletion or translocation of the entire chromosome arm, but no case of an interstitial chromosomal deletion was observed. Evidence for chromosomal instability in the progeny of irradiated cells also included clonal karyotypic heterogeneity. The persistence of instability was demonstrated for at least 80 generations by elevated mutation rates at the heterozygous, autosomal marker locus tk. Among those TK- mutants that showed a loss of heterozygosity, a statistically significant increase in mutation rate was observed only for those in which the loss of heterozygosity encompasses the telomeric region. This mutational specificity corresponds with the prevalence of terminal deletions, additions, and translocations, and the absence of interstitial deletions, in karyotypic analysis. Surprisingly, the elevated rate of TK- mutations is also partially attributable to intragenic base substitutions and small deletions, and DNA sequence analysis of some of these mutations is presented. Complex chromosomal abnormalities appear to be the most significant indicators of a high rate of persistent genetic instability which correlates with increased rates of both intragenic and chromosomal-scale mutations at tk.

Published
1996
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29. Patient Engagement With a Mobile Web-Based Telemonitoring System for Heart Failure Self-Management: A Pilot Study

Author

Zan, Shiyi, Agboola, Stephen, Moore, Stephanie A, Parks, Kimberly A, Kvedar, Joseph C, and Jethwani, Kamal

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundIntensive remote monitoring programs for congestive heart failure have been successful in reducing costly readmissions, but may not be appropriate for all patients. There is an opportunity to leverage the increasing accessibility of mobile technologies and consumer-facing digital devices to empower patients in monitoring their own health outside of the hospital setting. The iGetBetter system, a secure Web- and telephone-based heart failure remote monitoring program, which leverages mobile technology and portable digital devices, offers a creative solution at lower cost. ObjectiveThe objective of this pilot study was to evaluate the feasibility of using the iGetBetter system for disease self-management in patients with heart failure. MethodsThis was a single-arm prospective study in which 21 ambulatory, adult heart failure patients used the intervention for heart failure self-management over a 90-day study period. Patients were instructed to take their weight, blood pressure, and heart rate measurements each morning using a WS-30 bluetooth weight scale, a self-inflating blood pressure cuff (Withings LLC, Issy les Moulineaux, France), and an iPad Mini tablet computer (Apple Inc, Cupertino, CA, USA) equipped with cellular Internet connectivity to view their measurements on the Internet. Outcomes assessed included usability and satisfaction, engagement with the intervention, hospital resource utilization, and heart failure-related quality of life. Descriptive statistics were used to summarize data, and matched controls identified from the electronic medical record were used as comparison for evaluating hospitalizations. ResultsThere were 20 participants (mean age 53 years) that completed the study. Almost all participants (19/20, 95%) reported feeling more connected to their health care team and more confident in performing care plan activities, and 18/20 (90%) felt better prepared to start discussions about their health with their doctor. Although heart failure-related quality of life improved from baseline, it was not statistically significant (P=.55). Over half of the participants had greater than 80% (72/90 days) weekly and overall engagement with the program, and 15% (3/20) used the interactive voice response telephone system exclusively for managing their care plan. Hospital utilization did not differ in the intervention group compared to the control group (planned hospitalizations P=.23, and unplanned hospitalizations P=.99). Intervention participants recorded shorter average length of hospital stay, but no significant differences were observed between intervention and control groups (P=.30). ConclusionsThis pilot study demonstrated the feasibility of a low-intensive remote monitoring program leveraging commonly used mobile and portable consumer devices in augmenting care for a fairly young population of ambulatory patients with heart failure. Further prospective studies with a larger sample size and within more diverse patient populations is necessary to determine the effect of mobile-based remote monitoring programs such as the iGetBetter system on clinical outcomes in heart failure.

Published
2015
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30. Placer Dome Inc.

Author

Werniuk J., Parks K., Phillips P., Werniuk G., Werniuk J., Parks K., Phillips P., and Werniuk G.

Abstract

A series of articles is presented on the company's 14 gold mines (plus 1 copper mine) in six different countries, in North and South America, the Asia-Pacific region and South Africa. Topics include operations at the 50-year-old Campbell mine, the original Dome deposit and the new Musselwhite mine, in Ontario; low-cost Cortez, potentially long-term Getchell and the small, low-grade Bald Mountain, in Nevada; the mature and problem-ridden Golden Sunlight mine, in Montana; a brief survey of the Asia-Pacific mines Granny Smith in Western Australia, Porgera and Misima in Papua New Guinea and Kidston and Osborne gold-copper in Queensland; the La Coipa gold-silver and Zaldivar copper mine in Chile, with the Aldebaran and Cerro Casale projects and the suspended Venezuelan Las Cristinas; and the huge reserves and anticipated long life at the South Deep joint venture on the Witwatersrand reef in South Africa., A series of articles is presented on the company's 14 gold mines (plus 1 copper mine) in six different countries, in North and South America, the Asia-Pacific region and South Africa. Topics include operations at the 50-year-old Campbell mine, the original Dome deposit and the new Musselwhite mine, in Ontario; low-cost Cortez, potentially long-term Getchell and the small, low-grade Bald Mountain, in Nevada; the mature and problem-ridden Golden Sunlight mine, in Montana; a brief survey of the Asia-Pacific mines Granny Smith in Western Australia, Porgera and Misima in Papua New Guinea and Kidston and Osborne gold-copper in Queensland; the La Coipa gold-silver and Zaldivar copper mine in Chile, with the Aldebaran and Cerro Casale projects and the suspended Venezuelan Las Cristinas; and the huge reserves and anticipated long life at the South Deep joint venture on the Witwatersrand reef in South Africa.

35. Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability

Author

Lena F. Aeschbach, Balazs Aczel, Maria Vlachou, Blair Saunders, Jennifer A. Joy-Gaba, Ailsa E. Millen, Christopher R. Chartier, Danielle J. Kellier, Carlo Chiorri, Damian Pieńkosz, Tiago Jessé Souza de Lima, Sean Hughes, Carmel A. Levitan, Luca Andrighetto, Mallory C. Kidwell, Domenico Viganola, Sebastiaan Pessers, Sue Kraus, Claudia Chloe Brumbaugh, John E. Edlund, Ernest Baskin, Anna Fedor, Brett Mercier, Michał J. Białek, Sean Coary, Antonia M. Ciunci, Bence E. Bakos, Jon Grahe, Sabina Kołodziej, Radomir Belopavlović, Emilian Pękala, William J. Chopik, Rosanna E. Guadagno, Don A. Moore, Florian Brühlmann, Gideon Nave, Katarzyna Idzikowska, Rachel L. Shubella, Ryan J. Walker, Orsolya Szöke, Mathias Kauff, Ana Orlić, Sara Steegen, Hans IJzerman, Katarzyna Kuchno, Mitchell M. Metzger, Heather M. Claypool, Michael J. Wood, Samuel Lincoln Bezerra Lins, Michael C. Frank, Benjamin Dering, Iris Žeželj, Erica Baranski, Sophia C. Weissgerber, Timothy Razza, Leanne Boucher, Magnus Johannesson, R. Weylin Sternglanz, Yiling Chen, Maya B. Mathur, Christian Nunnally, Jonathan Ravid, Charles R. Ebersole, Lauren Skorb, Kurt Schuepfer, Łukasz Markiewicz, Thomas Schultze, Katherine S. Corker, Thomas Pfeiffer, Darko Stojilović, Oliver Christ, Kayla Ashbaugh, Alan Jern, Caio Ambrosio Lage, Filipe Falcão, Austin Lee Nichols, Peter Babincak, Mauro Giacomantonio, Sean C. Rife, Rafał Muda, Lacy E. Krueger, Jeremy K. Miller, Juliette Richetin, Martin Corley, Venus Meyet, W. Matthew Collins, Luana Elayne Cunha de Souza, Lynda A. R. Stein, Christopher Day, Erica Casini, Astrid Schütz, Ann-Kathrin Torka, Anna Dreber, Diane-Jo Bart-Plange, Steffen R. Giessner, Holly Arrow, Przemysław Sawicki, Joachim Hüffmeier, Ian R. Ferguson, Anna Dalla Rosa, Natasha Tidwell, Hause Lin, Matthew R. Penner, Boban Petrović, Bojana Bodroža, Janos Salamon, Josiah P. J. King, Mark Zrubka, Diane B. V. Bonfiglio, Stefan Schulz-Hardt, Emily Fryberger, Gabriel Baník, David Zealley, Amanda M. Kimbrough, Ewa Hałasa, William Jiménez-Leal, Angelo Panno, Karolina Krasuska, Michael Inzlicht, Jack Arnal, Madhavi Menon, Jia E. Loy, Vanessa S. Kolb, Nicholas G. Bloxsom, Michael H. Bernstein, Máire B. Ford, Grecia Kessinger, Marija V. Čolić, Wolf Vanpaemel, Barnabas Szaszi, Carly tocco, Nick Buttrick, Emanuele Preti, Andres Montealegre, Brian A. Nosek, Katarzyna Gawryluk, Kaylis Hase Rudy, Leigh Ann Vaughn, Anna Palinkas, Rúben Silva, Daniel Wolf, Sarah A. Novak, Aaron L. Wichman, Manuela Thomae, Adam Siegel, Ivana Pedović, Eleanor V. Langford, Kathleen Schmidt, Daniel Storage, Attila Szuts, Ljiljana B. Lazarević, Paul G. Curran, Rias A. Hilliard, Alexander Garinther, Joshua K. Hartshorne, Ani N. Shabazian, Tiago Ramos, Peter Szecsi, Hugh Rabagliati, Kimberly P. Parks, Lily Feinberg, Dylan Manfredi, Ivan Ropovik, Katrin Rentzsch, Michelangelo Vianello, Barbara Sioma, Marton Kovacs, Francis Tuerlinckx, Peter J. B. Hancock, Bradford J. Wiggins, Gavin Brent Sullivan, Danka Purić, Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social (LIP-PC2S), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Organisation and Personnel Management, Human Resource Excellence, Ebersole, C, Mathur, M, Baranski, E, Bart-Plange, D, Buttrick, N, Chartier, C, Corker, K, Corley, M, Hartshorne, J, Ijzerman, H, Lazarević, L, Rabagliati, H, Ropovik, I, Aczel, B, Aeschbach, L, Andrighetto, L, Arnal, J, Arrow, H, Babincak, P, Bakos, B, Baník, G, Baskin, E, Belopavlović, R, Bernstein, M, Białek, M, Bloxsom, N, Bodroža, B, Bonfiglio, D, Boucher, L, Brühlmann, F, Brumbaugh, C, Casini, E, Chen, Y, Chiorri, C, Chopik, W, Christ, O, Ciunci, A, Claypool, H, Coary, S, Čolić, M, Collins, W, Curran, P, Day, C, Dering, B, Dreber, A, Edlund, J, Falcão, F, Fedor, A, Feinberg, L, Ferguson, I, Ford, M, Frank, M, Fryberger, E, Garinther, A, Gawryluk, K, Ashbaugh, K, Giacomantonio, M, Giessner, S, Grahe, J, Guadagno, R, Hałasa, E, Hancock, P, Hilliard, R, Hüffmeier, J, Hughes, S, Idzikowska, K, Inzlicht, M, Jern, A, Jiménez-Leal, W, Johannesson, M, Joy-Gaba, J, Kauff, M, Kellier, D, Kessinger, G, Kidwell, M, Kimbrough, A, King, J, Kolb, V, Kołodziej, S, Kovacs, M, Krasuska, K, Kraus, S, Krueger, L, Kuchno, K, Lage, C, Langford, E, Levitan, C, de Lima, T, Lin, H, Lins, S, Loy, J, Manfredi, D, Markiewicz, Ł, Menon, M, Mercier, B, Metzger, M, Meyet, V, Millen, A, Miller, J, Montealegre, A, Moore, D, Muda, R, Nave, G, Nichols, A, Novak, S, Nunnally, C, Orlić, A, Palinkas, A, Panno, A, Parks, K, Pedović, I, Pękala, E, Penner, M, Pessers, S, Petrović, B, Pfeiffer, T, Pieńkosz, D, Preti, E, Purić, D, Ramos, T, Ravid, J, Razza, T, Rentzsch, K, Richetin, J, Rife, S, Rosa, A, Rudy, K, Salamon, J, Saunders, B, Sawicki, P, Schmidt, K, Schuepfer, K, Schultze, T, Schulz-Hardt, S, Schütz, A, Shabazian, A, Shubella, R, Siegel, A, Silva, R, Sioma, B, Skorb, L, de Souza, L, Steegen, S, Stein, L, Sternglanz, R, Stojilović, D, Storage, D, Sullivan, G, Szaszi, B, Szecsi, P, Szöke, O, Szuts, A, Thomae, M, Tidwell, N, Tocco, C, Torka, A, Tuerlinckx, F, Vanpaemel, W, Vaughn, L, Vianello, M, Viganola, D, Vlachou, M, Walker, R, Weissgerber, S, Wichman, A, Wiggins, B, Wolf, D, Wood, M, Zealley, D, Žeželj, I, Zrubka, M, Nosek, B, and Faculdade de Psicologia e de Ciências da Educação

Subjects
replication, metascience, Registered Reports, biology, media_common.quotation_subject, Curran, 05 social sciences, [SHS.PSY]Humanities and Social Sciences/Psychology, open data, Art history, 050109 social psychology, Art, biology.organism_classification, preregistered, 050105 experimental psychology, Attila, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], 0501 psychology and cognitive sciences, reproducibility, [STAT.ME]Statistics [stat]/Methodology [stat.ME], General Psychology, media_common
Abstract

Additional co-authors: Ivan Ropovik, Balazs Aczel, Lena F. Aeschbach, Luca Andrighetto, Jack D. Arnal, Holly Arrow, Peter Babincak, Bence E. Bakos, Gabriel Banik, Ernest Baskin, Radomir Belopavlovic, Michael H. Bernstein, Michal Bialek, Nicholas G. Bloxsom, Bojana Bodroža, Diane B. V. Bonfiglio, Leanne Boucher, Florian Bruhlmann, Claudia C. Brumbaugh, Erica Casini, Yiling Chen, Carlo Chiorri, William J. Chopik, Oliver Christ, Antonia M. Ciunci, Heather M. Claypool, Sean Coary, Marija V. Cˇolic, W. Matthew Collins, Paul G. Curran, Chris R. Day, Anna Dreber, John E. Edlund, Filipe Falcao, Anna Fedor, Lily Feinberg, Ian R. Ferguson, Maire Ford, Michael C. Frank, Emily Fryberger, Alexander Garinther, Katarzyna Gawryluk, Kayla Ashbaugh, Mauro Giacomantonio, Steffen R. Giessner, Jon E. Grahe, Rosanna E. Guadagno, Ewa Halasa, Rias A. Hilliard, Joachim Huffmeier, Sean Hughes, Katarzyna Idzikowska, Michael Inzlicht, Alan Jern, William Jimenez-Leal, Magnus Johannesson, Jennifer A. Joy-Gaba, Mathias Kauff, Danielle J. Kellier, Grecia Kessinger, Mallory C. Kidwell, Amanda M. Kimbrough, Josiah P. J. King, Vanessa S. Kolb, Sabina Kolodziej, Marton Kovacs, Karolina Krasuska, Sue Kraus, Lacy E. Krueger, Katarzyna Kuchno, Caio Ambrosio Lage, Eleanor V. Langford, Carmel A. Levitan, Tiago Jesse Souza de Lima, Hause Lin, Samuel Lins, Jia E. Loy, Dylan Manfredi, Łukasz Markiewicz, Madhavi Menon, Brett Mercier, Mitchell Metzger, Venus Meyet, Jeremy K. Miller, Andres Montealegre, Don A. Moore, Rafal Muda, Gideon Nave, Austin Lee Nichols, Sarah A. Novak, Christian Nunnally, Ana Orlic, Anna Palinkas, Angelo Panno, Kimberly P. Parks, Ivana Pedovic, Emilian Pekala, Matthew R. Penner, Sebastiaan Pessers, Boban Petrovic, Thomas Pfeiffer, Damian Pienkosz, Emanuele Preti, Danka Puric, Tiago Ramos, Jonathan Ravid, Timothy S. Razza, Katrin Rentzsch, Juliette Richetin, Sean C. Rife, Anna Dalla Rosa, Kaylis Hase Rudy, Janos Salamon, Blair Saunders, Przemyslaw Sawicki, Kathleen Schmidt, Kurt Schuepfer, Thomas Schultze, Stefan Schulz-Hardt, Astrid Schutz, Ani N. Shabazian, Rachel L. Shubella, Adam Siegel, Ruben Silva, Barbara Sioma, Lauren Skorb, Luana Elayne Cunha de Souza, Sara Steegen, L. A. R. Stein, R. Weylin Sternglanz, Darko Stojilovic, Daniel Storage, Gavin Brent Sullivan, Barnabas Szaszi, Peter Szecsi, Orsolya Szoke, Attila Szuts, Manuela Thomae, Natasha D. Tidwell, Carly Tocco, Ann-Kathrin Torka, Francis Tuerlinckx, Wolf Vanpaemel, Leigh Ann Vaughn, Michelangelo Vianello, Domenico Viganola, Maria Vlachou, Ryan J. Walker, Sophia C. Weissgerber, Aaron L. Wichman, Bradford J. Wiggins, Daniel Wolf, Michael J. Wood, David Zealley, Iris Žeželj, Mark Zrubka, and Brian A. Nosek

Published
2020
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36. Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction.

Author

Januzzi JL Jr, Rehman SU, Mohammed AA, Bhardwaj A, Barajas L, Barajas J, Kim HN, Baggish AL, Weiner RB, Chen-Tournoux A, Marshall JE, Moore SA, Carlson WD, Lewis GD, Shin J, Sullivan D, Parks K, Wang TJ, Gregory SA, and Uthamalingam S

Abstract

Objectives: The aim of this study was to evaluate whether chronic heart failure (HF) therapy guided by concentrations of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is superior to standard of care (SOC) management.Background: It is unclear whether standard HF treatment plus a goal of reducing NT-proBNP concentrations improves outcomes compared with standard management alone.Methods: In a prospective single-center trial, 151 subjects with HF due to left ventricular (LV) systolic dysfunction were randomized to receive either standard HF care plus a goal to reduce NT-proBNP concentrations ≤1,000 pg/ml or SOC management. The primary endpoint was total cardiovascular events between groups compared using generalized estimating equations. Secondary endpoints included effects of NT-proBNP-guided care on patient quality of life as well as cardiac structure and function, assessed with echocardiography.Results: Through a mean follow-up period of 10 ± 3 months, a significant reduction in the primary endpoint of total cardiovascular events was seen in the NT-proBNP arm compared with SOC (58 events vs. 100 events, p = 0.009; logistic odds for events 0.44, p = 0.02); Kaplan-Meier curves demonstrated significant differences in time to first event, favoring NT-proBNP-guided care (p = 0.03). No age interaction was found, with elderly patients benefitting similarly from NT-proBNP-guided care as younger subjects. Compared with SOC, NT-proBNP-guided patients had greater improvements in quality of life, demonstrated greater relative improvements in LV ejection fraction, and had more significant improvements in both LV end-systolic and -diastolic volume indexes.Conclusions: In patients with HF due to LV systolic dysfunction, NT-proBNP-guided therapy was superior to SOC, with reduced event rates, improved quality of life, and favorable effects on cardiac remodeling. (Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting; NCT00351390). [ABSTRACT FROM AUTHOR]

Published
2011
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37. Post-Transplant Maintenance Therapy in Acute Myeloid Leukemia.

Author

Parks K, Aslam MF, Kumar V, and Jamy O

Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for patients with acute myeloid leukemia (AML). However, the post-transplant relapse rate ranges from 40 to 70%, particularly with reduced intensity conditioning, and remains a major cause of treatment failure for these patients due to the limited efficacy of salvage therapy options. Strategies to mitigate this risk are urgently needed. In the past few years, the basic framework of post-transplant maintenance has been shaped by several clinical trials investigating targeted therapy, chemotherapy, and immunomodulatory therapies. Although the practice of post-transplant maintenance in AML has become more common, there remain challenges regarding the feasibility and efficacy of this strategy. Here, we review major developments in post-transplant maintenance in AML, along with ongoing and future planned studies in this area, outlining the limitations of available data and our future goals.

Published
2024
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38. Low-dose decitabine plus venetoclax as post-transplant maintenance for high-risk myeloid malignancies.

Author

Parks K, Diebold K, Salzman D, Di Stasi A, Al-Kadhimi Z, Espinoza-Gutarra M, Bhatia R, and Jamy O

Abstract

Relapse remains a major cause of treatment failure following allogeneic stem cell transplantation (allo-SCT) for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We retrospectively investigated low-dose decitabine and venetoclax (DEC/VEN) as post-transplant maintenance in 26 older patients with AML and MDS. The cumulative incidence of day 100 gIII-IV acute graft versus host disease (GVHD) and 1-year moderate-severe chronic GVHD was 5% and 26%, respectively. One patient relapsed 14 m after transplant. The 1-year non-relapse mortality and survival were 11% and 84%, respectively. DEC/VEN is a safe and potentially effective strategy to reduce the risk of post-transplant relapse., Competing Interests: The authors declare no conflict of interest., (© 2024 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)

Published
2024
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39. Crowdsourcing Skin Demarcations of Chronic Graft-Versus-Host Disease in Patient Photographs: Training Versus Performance Study.

Author

McNeil AJ, Parks K, Liu X, Jiang B, Coco J, McCool K, Fabbri D, Duhaime EP, Dawant BM, and Tkaczyk ER

Abstract

Background: Chronic graft-versus-host disease (cGVHD) is a significant cause of long-term morbidity and mortality in patients after allogeneic hematopoietic cell transplantation. Skin is the most commonly affected organ, and visual assessment of cGVHD can have low reliability. Crowdsourcing data from nonexpert participants has been used for numerous medical applications, including image labeling and segmentation tasks., Objective: This study aimed to assess the ability of crowds of nonexpert raters-individuals without any prior training for identifying or marking cGHVD-to demarcate photos of cGVHD-affected skin. We also studied the effect of training and feedback on crowd performance., Methods: Using a Canfield Vectra H1 3D camera, 360 photographs of the skin of 36 patients with cGVHD were taken. Ground truth demarcations were provided in 3D by a trained expert and reviewed by a board-certified dermatologist. In total, 3000 2D images (projections from various angles) were created for crowd demarcation through the DiagnosUs mobile app. Raters were split into high and low feedback groups. The performances of 4 different crowds of nonexperts were analyzed, including 17 raters per image for the low and high feedback groups, 32-35 raters per image for the low feedback group, and the top 5 performers for each image from the low feedback group., Results: Across 8 demarcation competitions, 130 raters were recruited to the high feedback group and 161 to the low feedback group. This resulted in a total of 54,887 individual demarcations from the high feedback group and 78,967 from the low feedback group. The nonexpert crowds achieved good overall performance for segmenting cGVHD-affected skin with minimal training, achieving a median surface area error of less than 12% of skin pixels for all crowds in both the high and low feedback groups. The low feedback crowds performed slightly poorer than the high feedback crowd, even when a larger crowd was used. Tracking the 5 most reliable raters from the low feedback group for each image recovered a performance similar to that of the high feedback crowd. Higher variability between raters for a given image was not found to correlate with lower performance of the crowd consensus demarcation and cannot therefore be used as a measure of reliability. No significant learning was observed during the task as more photos and feedback were seen., Conclusions: Crowds of nonexpert raters can demarcate cGVHD images with good overall performance. Tracking the top 5 most reliable raters provided optimal results, obtaining the best performance with the lowest number of expert demarcations required for adequate training. However, the agreement amongst individual nonexperts does not help predict whether the crowd has provided an accurate result. Future work should explore the performance of crowdsourcing in standard clinical photos and further methods to estimate the reliability of consensus demarcations., (©Andrew J McNeil, Kelsey Parks, Xiaoqi Liu, Bohan Jiang, Joseph Coco, Kira McCool, Daniel Fabbri, Erik P Duhaime, Benoit M Dawant, Eric R Tkaczyk. Originally published in JMIR Dermatology (http://derma.jmir.org), 26.12.2023.)

Published
2023
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40. mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RA int T EMRA -like CD8 + T cells in COVID-19 recovered individuals.

Author

Mayer-Blackwell K, Ryu H, Codd AS, Parks KR, MacMillan HR, Cohen KW, Stewart TL, Seese A, Lemos MP, De Rosa SC, Czartoski JL, Moodie Z, Nguyen LT, McGuire DJ, Ahmed R, Fiore-Gartland A, McElrath MJ, and Newell EW

Subjects
Humans, Memory T Cells, SARS-CoV-2, Vaccination, Epitopes, Leukocyte Common Antigens, CD8-Positive T-Lymphocytes, COVID-19 prevention & control
Abstract

SARS-CoV-2 infection and mRNA vaccination both elicit spike (S)-specific T cell responses. To analyze how T cell memory from prior infection influences T cell responses to vaccination, we evaluated functional T cell responses in naive and previously infected vaccine recipients. Pre-vaccine S-specific responses are predictive of subsequent CD8 + T cell vaccine-response magnitudes. Comparing baseline with post-vaccination TCRβ repertoires, we observed large clonotypic expansions correlated with the frequency of spike-specific T cells. Epitope mapping the largest CD8 + T cell responses confirms that an HLA-A∗03:01 epitope was highly immunodominant. Peptide-MHC tetramer staining together with mass cytometry and single-cell sequencing permit detailed phenotyping and clonotypic tracking of these S-specific CD8 + T cells. Our results demonstrate that infection-induced S-specific CD8 + T cell memory plays a significant role in shaping the magnitude and clonal composition of the circulating T cell repertoire after vaccination, with mRNA vaccination promoting CD8 + memory T cells to a T EMRA -like phenotype., Competing Interests: Declaration of interests E.W.N. is a cofounder, advisor, and shareholder of ImmunoScape and is an advisor for Neogene Therapeutics and NanoString Technologies., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2023
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41. Non-Expert Markings of Active Chronic Graft-Versus-Host Disease Photographs: Optimal Metrics of Training Effects.

Author

Parks K, Liu X, Reasat T, Khera Z, Baker LX, Chen H, Dawant BM, Saknite I, and Tkaczyk ER

Subjects
Humans, Algorithms, Skin, Chronic Disease, Bronchiolitis Obliterans Syndrome, Graft vs Host Disease
Abstract

Lack of reliable measures of cutaneous chronic graft-versus-host disease (cGVHD) remains a significant challenge. Non-expert assistance in marking photographs of active disease could aid the development of automated segmentation algorithms, but validated metrics to evaluate training effects are lacking. We studied absolute and relative error of marked body surface area (BSA), redness, and the Dice index as potential metrics of non-expert improvement. Three non-experts underwent an extensive training program led by a board-certified dermatologist to mark cGVHD in photographs. At the end of the 4-month training, the dermatologist confirmed that each trainee had learned to accurately mark cGVHD. The trainees' inter- and intra-rater intraclass correlation coefficient estimates were "substantial" to "almost perfect" for both BSA and total redness. For fifteen 3D photos of patients with cGVHD, the trainees' median absolute (relative) BSA error compared to expert marking dropped from 20 cm 2 (29%) pre-training to 14 cm 2 (24%) post-training. Total redness error decreased from 122 a*·cm 2 (26%) to 95 a*·cm 2 (21%). By contrast, median Dice index did not reflect improvement (0.76 to 0.75). Both absolute and relative BSA and redness errors similarly and stably reflected improvements from this training program, which the Dice index failed to capture., (© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

Published
2023
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42. Baseline Photos and Confident Annotation Improve Automated Detection of Cutaneous Graft-Versus-Host Disease.

Author

Liu X, Parks K, Saknite I, Reasat T, Cronin AD, Wheless LE, Dawant BM, and Tkaczyk ER

Abstract

Cutaneous erythema is used in diagnosis and response assessment of cutaneous chronic graft-versus-host disease (cGVHD). The development of objective erythema evaluation methods remains a challenge. We used a pre-trained neural network to segment cGVHD erythema by detecting changes relative to a patient's registered baseline photo. We fixed this change detection algorithm on human annotations from a single photo pair, by using either a traditional approach or by marking definitely affected ("Do Not Miss", DNM) and definitely unaffected skin ("Do Not Include", DNI). The fixed algorithm was applied to each of the remaining 47 test photo pairs from six follow-up sessions of one patient. We used both the Dice index and the opinion of two board-certified dermatologists to evaluate the algorithm performance. The change detection algorithm correctly assigned 80% of the pixels, regardless of whether it was fixed on traditional (median accuracy: 0.77, interquartile range 0.62-0.87) or DNM/DNI segmentations (0.81, 0.65-0.89). When the algorithm was fixed on markings by different annotators, the DNM/DNI achieved more consistent outputs (median Dice indices: 0.94-0.96) than the traditional method (0.73-0.81). Compared to viewing only rash photos, the addition of baseline photos improved the reliability of dermatologists' scoring. The inter-rater intraclass correlation coefficient increased from 0.19 (95% confidence interval lower bound: 0.06) to 0.51 (lower bound: 0.35). In conclusion, a change detection algorithm accurately assigned erythema in longitudinal photos of cGVHD. The reliability was significantly improved by exclusively using confident human segmentations to fix the algorithm. Baseline photos improved the agreement among two dermatologists in assessing algorithm performance., Competing Interests: The authors declare they have no conflicts of interest., (© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.)

Published
2021
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43. The Impact of a Culinary Coaching Telemedicine Program on Home Cooking and Emotional Well-Being during the COVID-19 Pandemic.

Author

Silver JK, Finkelstein A, Minezaki K, Parks K, Budd MA, Tello M, Paganoni S, Tirosh A, and Polak R

Subjects
Female, Humans, Male, Middle Aged, Obesity therapy, Psychological Tests, Resilience, Psychological, Surveys and Questionnaires, Adaptation, Psychological, COVID-19 psychology, Cooking methods, Education, Distance methods, Emotional Adjustment, Patient Education as Topic methods
Abstract

The coronavirus pandemic enforced social restrictions with abrupt impacts on mental health and changes to health behaviors. From a randomized clinical trial, we assessed the impact of culinary education on home cooking practices, coping strategies and resiliency during the first wave of the COVID-19 pandemic (March/April 2020). Participants ( n = 28) were aged 25-70 years with a BMI of 27.5-35 kg/m 2 . The intervention consisted of 12 weekly 30-min one-on-one telemedicine culinary coaching sessions. Coping strategies were assessed through the Brief Coping with Problems Experienced Inventory, and resiliency using the Brief Resilient Coping Scale. Home cooking practices were assessed through qualitative analysis. The average use of self-care as a coping strategy by the intervention group was 6.14 (1.66), compared to the control with 4.64 (1.69); p = 0.03. While more intervention participants had high ( n = 5) and medium ( n = 8) resiliency compared to controls ( n = 4, n = 6, respectively), this difference was not significant ( p = 0.33). Intervention participants reported using home cooking skills such as meal planning and time saving techniques during the pandemic. The key findings were that culinary coaching via telemedicine may be an effective intervention for teaching home cooking skills and promoting the use of self-care as a coping strategy during times of stress, including the COVID-19 pandemic.

Published
2021
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44. HIV pre-exposure prophylaxis (PrEP) knowledge, familiarity, and attitudes among United States healthcare professional students: A cross-sectional study.

Author

Przybyla S, Fillo J, Kamper-DeMarco K, Bleasdale J, Parks K, Klasko-Foster L, and Morse D

Abstract

The United States' initiative to End the HIV Epidemic by 2030 includes a primary goal to reduce new HIV infections by 90 percent. One key contributor to this plan is HIV pre-exposure prophylaxis (PrEP). While knowledge and acceptance of PrEP among clinicians is growing, few studies have assessed knowledge and awareness among future healthcare professionals in academic training programs. The present study aimed to assess and compare healthcare trainees' awareness, knowledge, and familiarity with PrEP prescribing guidelines to better understand and prevent gaps in academic training regarding PrEP. A cross-sectional web-based survey of medical, nurse practitioner, and pharmacy students enrolled at two universities was conducted between October 2017 and January 2018. The study assessed participants' awareness, knowledge, and familiarity with PrEP prescribing guidelines and willingness to prescribe PrEP and refer to another healthcare provider. The survey was completed by 744 participants (response rate = 36.2%). Overall, PrEP awareness was high though PrEP knowledge was low. There were significant differences among student groups in domains of interest. Pharmacy students had the greatest PrEP knowledge, awareness, and familiarity with prescribing guidelines. However, medical students reported the greatest comfort with performing PrEP-related clinical activities and willingness to refer a candidate to another provider. Study findings enhance our understanding of healthcare professional students' perspectives of PrEP as a biomedical prevention strategy for HIV. The gaps in students' knowledge offer opportunities for the development of educational strategies to support HIV prevention among future healthcare professionals., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2021 The Authors.)

Published
2021
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45. Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual.

Author

Seydoux E, Homad LJ, MacCamy AJ, Parks KR, Hurlburt NK, Jennewein MF, Akins NR, Stuart AB, Wan YH, Feng J, Nelson RE, Singh S, Cohen KW, McElrath MJ, Englund JA, Chu HY, Pancera M, McGuire AT, and Stamatatos L

Abstract

B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one days post-infection. Forty-four S2P-specific monoclonal antibodies were generated, three of which bound to the receptor binding domain (RBD). The antibodies were minimally mutated from germline and were derived from different B cell lineages. Only two antibodies displayed neutralizing activity against SARS-CoV-2 pseudo-virus. The most potent antibody bound the RBD in a manner that prevented binding to the ACE2 receptor, while the other bound outside the RBD. Our study indicates that the majority of antibodies against the viral envelope spike that were generated during the first weeks of COVID-19 infection are non-neutralizing and target epitopes outside the RBD. Antibodies that disrupt the SARS-CoV-2 spike-ACE2 interaction can potently neutralize the virus without undergoing extensive maturation. Such antibodies have potential preventive/therapeutic potential and can serve as templates for vaccine-design., Competing Interests: DECLARATION OF INTERESTS The authors declare no competing financial interests. A provisional patent application on the antibodies discussed here has been filed. HYC: Merck, Sanofi-Pasteur, GSK

Published
2020
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46. Home Meal Preparation: A Powerful Medical Intervention.

Author

Klein L and Parks K

Abstract

One of the principles of culinary medicine is to help patients learn how to make nutritious eating simple and easy. In this column, you will learn tools for preparing and storing food; a key component to successful home cooking. While this article is intended to help clinicians learn about food preparation, it is also designed to be used as an educational tool for patients., Competing Interests: Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Laura Klein provides professional training in culinary medicine. Dr Parks is the owner of a culinary medicine practice., (© 2020 The Author(s).)

Published
2020
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47. Culinary Medicine: Paving the Way to Health Through Our Forks.

Author

Parks K and Polak R

Abstract

Recent findings reveal that suboptimal diet is responsible for more deaths than any other risk factor nationally and globally. It is estimated that with improving eating behaviors, 1 in 5 deaths can be prevented, underscoring the urgent need for effective dietary interventions., Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© 2019 The Author(s).)

Published
2019
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48. Disruption of Chloroplast Function Through Downregulation of Phytoene Desaturase Enhances the Systemic Accumulation of an Aphid-Borne, Phloem-Restricted Virus.

Author

DeBlasio SL, Rebelo AR, Parks K, Gray SM, and Heck MC

Subjects
Animals, Down-Regulation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Plant, Gene Silencing, Insect Vectors, Luteoviridae, Oxidoreductases genetics, Nicotiana metabolism, Aphids virology, Chloroplasts enzymology, Oxidoreductases metabolism, Phloem virology, Nicotiana virology
Abstract

Chloroplasts play a central role in pathogen defense in plants. However, most studies explaining the relationship between pathogens and chloroplasts have focused on pathogens that infect mesophyll cells. In contrast, the family Luteoviridae includes RNA viruses that replicate and traffic exclusively in the phloem. Recently, our lab has shown that Potato leafroll virus (PLRV), the type species in the genus Polerovirus, forms an extensive interaction network with chloroplast-localized proteins that is partially dependent on the PLRV capsid readthrough domain (RTD). In this study, we used virus-induced gene silencing to disrupt chloroplast function and assess the effects on PLRV accumulation in two host species. Silencing of phytoene desaturase (PDS), a key enzyme in carotenoid, chlorophyll, and gibberellic acid (GA) biosynthesis, resulted in a substantial increase in the systemic accumulation of PLRV. This increased accumulation was attenuated when plants were infected with a viral mutant that does not express the RTD. Application of GA partially suppressed the increase in virus accumulation in PDS-silenced plants, suggesting that GA signaling also plays a role in limiting PLRV infection. In addition, the fecundity of the aphid vector of PLRV was increased when fed on PDS-silenced plants relative to PLRV-infected plants.

Published
2018
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49. Early progressive feeding in extremely preterm infants: a randomized trial.

Author

Salas AA, Li P, Parks K, Lal CV, Martin CR, and Carlo WA

Subjects
Birth Weight, Diet, Enteral Nutrition, Enterocolitis, Necrotizing diagnosis, Enterocolitis, Necrotizing therapy, Female, Gestational Age, Humans, Infant, Infant Formula, Infant, Newborn, Infant, Very Low Birth Weight growth & development, Male, Milk, Human, Parenteral Nutrition, Treatment Outcome, Infant Nutritional Physiological Phenomena, Infant, Extremely Premature growth & development
Abstract

Background: Due to insufficient evidence, extremely preterm infants (≤28 wk of gestation) rarely receive early progressive feeding (small increments of feeding volumes between 1 and 4 d after birth). We hypothesized that early progressive feeding increases the number of full enteral feeding days in the first month after birth., Objective: The aim of this study was to determine the feasibility and efficacy of early progressive feeding in extremely preterm infants., Design: In this single-center randomized trial, extremely preterm infants born between September 2016 and June 2017 were randomly assigned to receive either early progressive feeding without trophic feeding (early feeding group) or delayed progressive feeding after a 4-d course of trophic feeding (delayed feeding group). Treatment allocation occurred before or on feeding day 1. The primary outcome was the number of full enteral feeding days in the first month after birth. Secondary outcomes were death, necrotizing enterocolitis (NEC), culture-proven sepsis, growth percentiles at 36 wk postmenstrual age, use of parenteral nutrition, and need for central venous access., Results: Sixty infants were included (median gestational age: 26 wk; mean ± SD birth weight: 832 ± 253 g). The primary outcome differed between groups (median difference favoring the early feeding group: +2 d; 95% CI: 0, 3 d; P = 0.02). Early progressive feeding reduced the use of parenteral nutrition (4 compared with 8 d; P ≤ 0.01) and the need for central venous access (9 compared with 13 d; P ≤ 0.01). The outcome of culture-proven sepsis (10% compared with 27%; P = 0.18), restricted growth (weight, length, and head circumference <10th percentile) at 36 wk postmenstrual age (25% compared with 50%; P = 0.07), and the composite outcome of NEC or death (27% compared with 20%; P = 0.74) did not differ between groups., Conclusion: Early progressive feeding increases the number of full enteral feeding days in extremely preterm infants. This trial was registered at www.clinicaltrials.gov as NCT02915549.

Published
2018
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50. Prognosis, Communication, and Advance Care Planning in Heart Failure: A Module for Students, Residents, Fellows, and Practicing Clinicians.

Author

Zehm A, Lindvall C, Parks K, Schaefer K, and Chittenden E

Abstract

Introduction: The increasing prevalence, high symptom burden, and medical advances that often prolong the advanced phase of heart failure mandate an organized and thoughtful approach to medical decision making. However, many clinicians have difficulty discussing prognosis and goals of care with patients. Barriers include disease- and therapy-specific prognostication challenges in heart failure and a lack of evidence-based primary palliative care education initiatives., Methods: In response, we developed this 45-minute training module, which consists of a case-based small-group session and a communication guide. The curriculum highlights prognostication challenges in heart failure and introduces an illness trajectory-based framework to cue iterative goals of care conversations., Results: We piloted this learning module with 46 internal medicine residents and interdisciplinary palliative care fellows in groups of three to 15 and obtained anonymous quantitative and qualitative postsession learner survey data to examine feasibility and acceptability. Trainees rated the session highly. One hundred percent of learners either strongly agreed or agreed the session was clinically useful. Learners unanimously found the teaching methods effective, and most felt they could easily apply these skills to their clinical work. In open-ended feedback, learners said the session gave them a better understanding of the heart failure illness trajectory, an improved framework for discussing goals of care with heart failure patients, and specific language to use when having these discussions., Discussion: This module represents a new paradigm for teaching both prognostication and advance care planning in heart failure in which illness trajectory guides timing and content of goals of care conversations., Competing Interests: Dr. Zehm reports personal fees from Integritas Communications outside the submitted work. Dr. Lindvall reports grants from the National Palliative Care Research Center and the Palliative Care Research Cooperative Group outside the submitted work.

Published
2017
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