1. A Mathematical Model of Corneal Metabolism in the Presence of an Iris-Fixated Phakic Intraocular Lens
- Author
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Rodolfo Repetto, Paolo Soleri, Xi Cheng, Peter M. Pinsky, Peyman Davvalo Khongar, and Jan O. Pralits
- Subjects
Adult ,Phakic Intraocular Lenses ,medicine.medical_specialty ,Corneal endothelium ,genetic structures ,Endothelium ,medicine.medical_treatment ,intraocular lens ,Iris ,Intraocular lens ,Phakic intraocular lens ,01 natural sciences ,010305 fluids & plasmas ,Aqueous Humor ,03 medical and health sciences ,0302 clinical medicine ,Lens Implantation, Intraocular ,nutrient transport ,Ophthalmology ,Cornea ,0103 physical sciences ,medicine ,Humans ,Iris (anatomy) ,aqueous flow ,corneal endothelial cells ,mathematical model ,business.industry ,Endothelium, Corneal ,General Medicine ,Models, Theoretical ,eye diseases ,Glucose ,medicine.anatomical_structure ,Lens (anatomy) ,030221 ophthalmology & optometry ,Female ,sense organs ,Eyelid ,Sleep ,business - Abstract
Purpose Corneal endothelial cell loss is one of the possible complications associated with phakic iris-fixated intraocular lens (PIOL) implantation. We postulate that this might be connected to the alteration of corneal metabolism secondary to the lens implantation. Methods A mathematical model of transport and consumption/production of metabolic species in the cornea is proposed, coupled with a model of aqueous flow and transport of metabolic species in the anterior chamber. Results Results are presented both for open and closed eyelids. We showed that, in the presence of a PIOL, glucose availability at the corneal endothelium decreases significantly during sleeping. Conclusions Implantation of a PIOL significantly affects nutrient transport processes to the corneal endothelium especially during sleep. It must still be verified whether this finding has a clinical relevance.
- Published
- 2019