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5. Prevalence of recurrent oncogenic fusion in mismatch repair-deficient colorectal carcinoma with hypermethylated MLH1 and wild-type BRAF and KRAS

Author

Wang, Jing, Yi, Yuting, Xiao, Yi, Dong, Lin, Liang, Li, Teng, Lianghong, Ying, Jian Ming, Lu, Tao, Liu, Yuanyuan, Guan, Yanfang, Pang, Junyi, Zhou, Lianrui, Lu, Junliang, Zhang, Zhiwen, Liu, Xiaoding, Liang, Xiaolong, Zeng, Xuan, Yi, Xin, Zhou, Weixun, Xia, Xuefeng, Yang, Ling, Zhang, Jianjun, Kopetz, Scott, Futreal, P.Andrew, Wu, Huanwen, and Liang, Zhiyong

Published
2019
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6. Feed nutritional composition affects the intestinal microbiota and digestive enzyme activity of black soldier fly larvae

Author

Chen, Guozhong, primary, Zhang, Kai, additional, Tang, Wenli, additional, Li, Youzhi, additional, Pang, Junyi, additional, Yuan, Xin, additional, Song, Xiangbin, additional, Jiang, Linlin, additional, Yu, Xin, additional, Zhu, Hongwei, additional, Wang, Jiao, additional, Zhang, Jianlong, additional, and Zhang, Xingxiao, additional

Published
2023
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9. Prevalence of Epstein–Barr Virus Infection and Mismatch Repair Protein Deficiency and the Correlation of Immune Markers in Tibetan Patients with Gastric Cancer

Author

Shi, Jie, primary, Yang, Xu, additional, Wang, Xinmei, additional, Luo, Yufeng, additional, Zhou, Weixun, additional, Luo, Hanhuan, additional, Bianba, Zhaxi, additional, Nima, Zhuoma, additional, Wang, Qian, additional, Wang, Han, additional, Liao, Ruiqian, additional, Ciren, Quzhen, additional, Li, Mei, additional, and Pang, Junyi, additional

Published
2022
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10. Additional file 2 of Prognostic significance of different molecular typing methods and immune status based on RNA sequencing in HR-positive and HER2-negative early-stage breast cancer

Author

Ren, Xinyu, Song, Yu, zhang, Yanna, Wu, Huanwen, Chen, Longyun, Pang, Junyi, Zhou, Liangrui, Shen, Songjie, and Liang, Zhiyong

Abstract

Additional file 2: Supplementary table 1. Genes detected in this study. Supplementary table 2. The PAM50 molecular subtype of tumors from patients with local recurrence, distant metastasis, or death.

Published
2022
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11. Additional file 1 of Prognostic significance of different molecular typing methods and immune status based on RNA sequencing in HR-positive and HER2-negative early-stage breast cancer

Author

Ren, Xinyu, Song, Yu, zhang, Yanna, Wu, Huanwen, Chen, Longyun, Pang, Junyi, Zhou, Liangrui, Shen, Songjie, and Liang, Zhiyong

Abstract

Additional file 1: Supplementary Figure S1. ROC curve of immune score. Supplementary Figure S2. Prognosis evaluation of intrinsic subtype of Luminal A, Luminal B and Basal-like subtype of PAM50.

Published
2022
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20. Prevalence of recurrent oncogenic fusion in mismatch repair-deficient colorectal carcinoma with hypermethylated MLH1and wild-type BRAFand KRAS

Author

Wang, Jing, Yi, Yuting, Xiao, Yi, Dong, Lin, Liang, Li, Teng, Lianghong, Ying, Jian Ming, Lu, Tao, Liu, Yuanyuan, Guan, Yanfang, Pang, Junyi, Zhou, Lianrui, Lu, Junliang, Zhang, Zhiwen, Liu, Xiaoding, Liang, Xiaolong, Zeng, Xuan, Yi, Xin, Zhou, Weixun, Xia, Xuefeng, Yang, Ling, Zhang, Jianjun, Kopetz, Scott, Futreal, P.Andrew, Wu, Huanwen, and Liang, Zhiyong

Abstract

Oncogenic fusions are rare in colorectal carcinomas, but may be important for prognosis and therapy. An effective strategy for screening targetable oncogenic fusions in colorectal carcinomas is needed. Here, we investigate molecular genetic alterations in colorectal carcinomas based on their DNA mismatch repair status, and to effectively screen for targetable oncogenic fusions in colorectal carcinomas. In this retrospective study, the initial cohort included 125 consecutive mismatch repair-deficient and 238 randomly selected mismatch repair-proficient colorectal carcinomas diagnosed between July 2015 and December 2017 at Peking Union Medical College Hospital. Targeted sequencing was performed. MLH1promoter hypermethylation analysis was further employed for subgrouping dMMR colorectal carcinomas. Clinicopathological characteristics, molecular features, and survival outcome of colorectal carcinomas harboring oncogenic fusions were assessed. A multicenter cohort comprised of 227 colorectal carcinomas with dual loss of MLH1/PMS2 was used to validate the efficacy of the proposed screening strategy for oncogenic fusions. Of the 363 patients in the initial cohort, 11(3.0%) harbored oncogenic fusions and were all mismatch repair-deficient colorectal carcinomas with hypermethylated MLH1and wild-type BRAFand KRAS, comprising 55% (11/20) of this subgroup. These patients with oncogenic fusions showed poorer 3-year cancer-specific survival compared with other Stage III/IV mismatch repair-deficient colorectal carcinoma patients (40% vs. 97%), and significantly higher CD274(PD-L1) expression in tumor cells compared with other dMMR colorectal carcinoma patients (46% vs. 6.1%, P< 0.001). An easy-to-perform and cost-efficient strategy for screening targetable fusions was proposed based on the current molecular testing algorithms for colorectal carcinomas, and validated in an independent multicenter cohort. In conclusion, oncogenic fusions were highly enriched and frequently detected in mismatch repair-deficient colorectal carcinomas with MLH1hypermethylation and wild-type BRAFand KRAS, and were associated with poor prognosis and high tumor CD274(PD-L1) expression.

Published
2019
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