348 results on '"Pagani, G"'
Search Results
2. Diagnostic Yield of Exome Sequencing in Prenatal Agenesis of Corpus Callosum: Systematic Review and Meta-Analysis
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Mustafa, H. J., Barbera, J. P., Sambatur, E. V., Pagani, G., Yaron, Y., Baptiste, C. D., Wapner, R. J., Brewer, C. J., Khalil, A., Mustafa, H. J., Barbera, J. P., Sambatur, E. V., Pagani, G., Yaron, Y., Baptiste, C. D., Wapner, R. J., Brewer, C. J., and Khalil, A.
- Abstract
OBJECTIVES: To determine the incremental diagnostic yield of exome sequencing (ES) after negative chromosomal microarray analysis (CMA) in cases of prenatally diagnosed agenesis of the corpus callosum (ACC) and to identify the associated genes and variants. METHODS: A systematic search was performed to identify relevant studies published up until June 2022 using four databases: PubMed, SCOPUS, Web of Science and The Cochrane Library. Studies in English reporting on the diagnostic yield of ES following negative CMA in prenatally diagnosed partial or complete ACC were included. Authors of cohort studies were contacted for individual participant data and extended cohorts were provided for two of them. The increase in diagnostic yield with ES for pathogenic/likely pathogenic (P/LP) variants was assessed in all cases of ACC, isolated ACC, ACC with other cranial anomalies and ACC with extracranial anomalies. To identify all reported genetic variants, the systematic review included all ACC cases; however, for the meta-analysis, only studies with ≥ three ACC cases were included. Meta-analysis of proportions was employed using a random-effects model. Quality assessment of the included studies was performed using modified Standards for Reporting of Diagnostic Accuracy criteria. RESULTS: A total of 28 studies, encompassing 288 prenatally diagnosed ACC cases that underwent ES following negative CMA, met the inclusion criteria of the systematic review. We classified 116 genetic variants in 83 genes associated with prenatal ACC with a full phenotypic description. There were 15 studies, encompassing 268 cases, that reported on ≥ three ACC cases and were included in the meta-analysis. Of all the included cases, 43% had a P/LP variant on ES. The highest yield was for ACC with extracranial anomalies (55% (95% CI, 35-73%)), followed by ACC with other cranial anomalies (43% (95% CI, 30-57%)) and isolated ACC (32% (95% CI, 18-51%)). CONCLUSIONS: ES demonstrated an incremental diagnostic
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- 2024
3. No yield stress required: Stress-activated flow in simple yield-stress fluids
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Pagani, G., primary, Hofmann, M., additional, Govaert, L. E., additional, Tervoort, T. A., additional, and Vermant, J., additional
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- 2024
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4. Diagnostic accuracy of prenatal ultrasound in coarctation of aorta: systematic review and individual participant data meta‐analysis
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Villalaín, C., primary, D'Antonio, F., additional, Flacco, M. E., additional, Gómez‐Montes, E., additional, Herraiz, I., additional, Deiros‐Bronte, L., additional, Maskatia, S. A., additional, Phillips, A. A., additional, Contro, E., additional, Fricke, K., additional, Bhawna, A., additional, Beattie, M. J., additional, Moon‐Grady, A. J., additional, Durand, I., additional, Slodki, M., additional, Respondek‐Liberska, M., additional, Patel, C., additional, Kawamura, H., additional, Rizzo, G., additional, Pagani, G., additional, and Galindo, A., additional
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- 2024
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5. A PMT-Block test bench
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Adragna, P., Antonaki, A., Boudagov, I., Cavasinni, V., Costanzo, D., Del Prete, T., Dotti, A., Fassouliotis, D., Giakoumopoulou, V., Giokaris, N., Guicheney, C., Karali, E., Khubua, J., Lebessi, M., Lupi, A., Manoussakis, A., Mazzoni, E., Minashvili, I., Morphi, M., Pagani, G. F., Paoletti, R., Rizzi, D., Roda, C., Sarri, F., Staveris-Polykalas, Ath., Staveris-Polykalas, Th., Stoudenov, S., Usai, G., Vazeille, F., Vellidis, C., Vichou, I., Vivarelli, I., and Volpi, M.
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Physics - Instrumentation and Detectors - Abstract
The front-end electronics of the ATLAS hadronic calorimeter (Tile Cal) is housed in a unit, called {\it PMT-Block}. The PMT-Block is a compact instrument comprising a light mixer, a PMT together with its divider and a {\it 3-in-1} card, which provides shaping, amplification and integration for the signals. This instrument needs to be qualified before being assembled on the detector. A PMT-Block test bench has been developed for this purpose. This test bench is a system which allows fast, albeit accurate enough, measurements of the main properties of a complete PMT-Block. The system, both hardware and software, and the protocol used for the PMT-Blocks characterisation are described in detail in this report. The results obtained in the test of about 10000 PMT-Blocks needed for the instrumentation of the ATLAS (LHC-CERN) hadronic Tile Calorimeter are also reported., Comment: 23 pages, 10 figures
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- 2006
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6. Diagnostic Yield of Exome Sequencing in Prenatal Agenesis of Corpus Callosum: A Systematic Review and Meta‐analysis
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Mustafa, H. J., primary, Barbera, J. P., additional, Sambatur, E. V., additional, Pagani, G., additional, Yaron, Y., additional, Baptiste, C. D., additional, Wapner, R. J., additional, Brewer, C. J., additional, and Khalil, A., additional
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- 2023
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7. OC03.05: Intravenous immunoglobulin for the treatment of severe maternal alloimmunisation: individual patient data meta‐analysis.
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Mustafa, H., Sambatur, E., Pagani, G., D'Antonio, F., Maisonneuve, E., Maurice, P., Zwiers, C., Verweij, J., Flood, A., Shamshirsaz, A., Jouannic, J., and Khalil, A.
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ERYTHROBLASTOSIS fetalis ,ERYTHROCYTES ,NEONATAL death ,HOSPITAL admission & discharge ,INTRAVENOUS immunoglobulins ,HYDROPS fetalis - Abstract
This article, titled "OC03.05: Intravenous immunoglobulin for the treatment of severe maternal alloimmunisation: individual patient data meta-analysis," explores the outcomes associated with the use of maternal intravenous immunoglobulin (IVIG) in high-risk pregnancies with red blood cell (RBC) alloimmunisation. The researchers conducted a systematic search of various databases and included studies that reported on pregnancies with severe RBC alloimmunisation and were treated with IVIG. The analysis of individual patient data from eight studies showed that IVIG was associated with prolonged gestational age at first intrauterine transfusion, reduced risk of fetal hydrops and fetal demise, and increased chances of livebirth and survival. The study suggests that IVIG treatment may have a beneficial effect on the course and severity of severe early hemolytic disease of the fetus and newborn (HDFN) in at-risk pregnancies. [Extracted from the article]
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- 2024
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8. Outcome of monochorionic twin pregnancy with selective intrauterine growth restriction according to umbilical artery Doppler flow pattern of smaller twin: systematic review and meta‐analysis
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Buca, D., Pagani, G., Rizzo, G., Familiari, A., Flacco, M. E., Manzoli, L., Liberati, M., Fanfani, F., Scambia, G., and DʼAntonio, F.
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- 2017
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9. MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism
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Bezzecchi, E., Pagani, G., Forte, B., Percio, S., Zaffaroni, N., Dolfini, D., and Gandellini, P.
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Settore MED/04 - Patologia Generale ,Alu ,ChIRP ,triplex ,long noncoding RNA ,sequencing ,Cell Biology ,Developmental Biology - Abstract
Aside serving as host gene for miR-205, MIR205HG transcribes for a chromatin-associated long noncoding RNA (lncRNA) able to restrain the differentiation of prostate basal cells, thus being reannotated as LEADR (Long Epithelial Alu-interacting Differentiation-related RNA). We previously showed the presence of Alu sequences in the promoters of genes modulated upon MIR205HG/LEADR manipulation. Notably, an Alu element also spans the first and second exons of MIR205HG/LEADR, suggesting its possible involvement in target selection/binding. Here, we performed ChIRP-seq to map MIR205HG/LEADR chromatin occupancy at genome-wide level in prostate basal cells. Our results confirmed preferential binding to regions proximal to gene transcription start site (TSS). Moreover, enrichment of triplex-forming sequences was found upstream of MIR205HG/LEADR-bound genes, peaking at −1,500/−500 bp from TSS. Triplexes formed with one or two putative DNA binding sites within MIR205HG/LEADR sequence, located just upstream of the Alu element. Notably, triplex-forming regions of bound genes were themselves enriched in Alu elements. These data suggest, from one side, that triplex formation may be the prevalent mechanism by which MIR205HG/LEADR selects and physically interacts with target DNA, from the other that direct or protein-mediated Alu (RNA)/Alu (DNA) interaction may represent a further functional requirement. We also found that triplex-forming regions were enriched in specific histone modifications, including H3K4me1 in the absence of H3K27ac, H3K4me3 and H3K27me3, indicating that in prostate basal cells MIR205HG/LEADR may preferentially bind to primed proximal regulatory elements. This may underscore the need for basal cells to keep MIR205HG/LEADR target genes repressed but, at the same time, responsive to differentiation cues.
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- 2022
10. Diagnostic accuracy of ultrasound in predicting birth‐weight discordance in twin pregnancy: systematic review and meta‐analysis
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Leombroni, M., Liberati, M., Fanfani, F., Pagani, G., Familiari, A., Buca, D., Manzoli, L., Scambia, G., Rizzo, G., and DʼAntonio, F.
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- 2017
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11. CM from intact hAM: an easily obtained product with relevant implications for translation in regenerative medicine
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Silini, A. R., Papait, Andrea, Cargnoni, A., Vertua, E., Romele, Pietro, Bonassi Signoroni, P., Magatti, M., De Munari, S., Masserdotti, Alice, Pasotti, A., Rota Nodari, S., Pagani, G., Bignardi, M., Parolini, Ornella, Papait A. (ORCID:0000-0003-1229-9671), Romele P., Masserdotti A., Parolini O. (ORCID:0000-0002-5211-6430), Silini, A. R., Papait, Andrea, Cargnoni, A., Vertua, E., Romele, Pietro, Bonassi Signoroni, P., Magatti, M., De Munari, S., Masserdotti, Alice, Pasotti, A., Rota Nodari, S., Pagani, G., Bignardi, M., Parolini, Ornella, Papait A. (ORCID:0000-0003-1229-9671), Romele P., Masserdotti A., and Parolini O. (ORCID:0000-0002-5211-6430)
- Abstract
Background: It is now well established that factors (free or in extracellular vesicles) secreted by mesenchymal stromal cells (MSC) are important mediators of MSC regenerative actions. Herein we produced the secretome (conditioned medium, CM) from MSC isolated from the amniotic membrane (hAMSC) and CM from the intact amniotic membrane (hAM, no manipulation or enzymatic digestion) in order to potentially identify an effective, easy and less expensive secretome to produce for potential applications in regenerative medicine. Given that immunomodulation is a key mechanism of action through which hAMSC contributes to tissue regeneration, we used a comprehensive panel of in vitro immunomodulatory tests to compare the CMs. Methods: Amniotic membranes were either cut into fragments or used for hAMSC isolation. CMs from hAMSC at passages 0 and 2 were collected after a standard 5-day culture while CM from hAM was collected after a 2- and 5-day culture. Immunomodulation was assessed in terms of PBMC and T-cell proliferation, T-cell subset polarization, T-regulatory cell induction, cell cytotoxicity and monocyte differentiation toward antigen-presenting cells. Furthermore, we performed a comparison between CM obtained from single donors and pooled CM. We also assessed the impact of lyophilization on the immunomodulatory properties of CM. Results: We demonstrate that CM from hAM has comparable immunomodulatory properties to CM from hAMSC at passages 0 and 2. Furthermore, we demonstrate that pooled CMs have similar effects when compared to CM from single donors used separately. Finally, we demonstrate that lyophilization does not alter the in vitro immunomodulatory properties of CM from hAM and hAMSC. Conclusions: The results presented herein support the possibility to produce secretome from intact hAM and open the prospect to highly improve the scalability of the GMP production process while reducing the costs and time related to the process of cell isolation and expansion. More
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- 2021
12. Missed Opportunities of Flu Vaccination in Italian Target Categories: Insights from the Online EPICOVID 19 Survey
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Giacomelli, A., Galli, M., Maggi, S., Pagani, G., Incalzi, R. A., Pedone, C., Di Bari, M., Noale, M., Trevisan, C., Bianchi, F., Tavio, M., Andreoni, M., Mastroianni, C., Sojic, A., Prinelli, F., Adorni, F., and EPICOVID 19 Working Group
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Immunology ,lcsh:Medicine ,Convenience sample ,Influenza season ,covid-19 ,elderly ,influenza ,italy ,sars-cov-2 ,vaccine ,030204 cardiovascular system & hematology ,Logistic regression ,Article ,Odds ,03 medical and health sciences ,0302 clinical medicine ,Drug Discovery ,Medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Pharmacology ,business.industry ,SARS-CoV-2 ,lcsh:R ,COVID-19 ,Italy ,Odds ratio ,Confidence interval ,Vaccination ,Infectious Diseases ,Nursing homes ,business ,Demography - Abstract
We aimed to assess the reported rate of flu vaccination in the 2019/2020 season for respondents to the Italian nationwide online EPICOVID 19 survey. A national convenience sample of volunteers aged 18 or older was assessed between 13 April and 2 June 2020. Flu vaccine rates were calculated for all classes of age. The association between the independent variables and the flu vaccine was assessed by applying a multivariable binary logistic regression model. Of the 198,822 respondents, 41,818 (21.0%) reported having received a flu vaccination shot during the last influenza season. In particular, 15,009 (53.4%) subjects aged 65 years or older received a flu vaccination shot. Being 65 years aged or older (Adjusted Odds Ratios (aOR) 3.06, 95% Confidence Interval (CI) 2.92&ndash, 3.20) and having a high education level (aOR 1.34. 95%CI 1.28&ndash, 1.41) were independently associated to flu vaccination. Heart and lung diseases were the morbidities associated with the higher odds of being vaccinated (aOR 1.97 (95%CI 1.86&ndash, 2.09) and aOR 1.92 (95%CI 1.84&ndash, 2.01), respectively). Nursing home residents aged &ge, 65 years showed lower odds of being vaccinated (aOR 0.39 (95%CI 0.28&ndash, 0.54)). Our data indicate the need for an urgent public heath effort to fill the gap of missed vaccination opportunities reported in the past flu seasons.
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- 2020
13. Neurodevelopmental outcome in isolated mild fetal ventriculomegaly: systematic review and meta-analysis
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Pagani, G., Thilaganathan, B., and Prefumo, F.
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- 2014
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14. Association between reduced fetal movements at term and abnormal uterine artery Doppler indices
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Pagani, G., DʼAntonio, F., Khalil, A., Akolekar, R., Papageorghiou, A., Bhide, A., and Thilaganathan, B.
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- 2014
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15. Fetal weight estimation in gestational diabetic pregnancies: comparison between conventional and three-dimensional fractional thigh volume methods using gestation-adjusted projection
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Pagani, G., Palai, N., Zatti, S., Fratelli, N., Prefumo, F., and Frusca, T.
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- 2014
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16. How Useful Are Tumor Markers in Detecting Metastases with FDG-PET/CT during Breast Cancer Surveillance?
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Corso, G, Gilardi, L, Girardi, A, De Scalzi, A, Pagani, G, Rossi, E, Montagna, G, Veronesi, P, Pagan, E, Bagnardi, V, Grana, C, Corso, Giovanni, Gilardi, Laura, Girardi, Antonia, De Scalzi, Alessandra Margherita, Pagani, Gianmatteo, Rossi, Elisabetta Maria Cristina, Montagna, Giacomo, Veronesi, Paolo, Pagan, Eleonora, Bagnardi, Vincenzo, Grana, Chiara Maria, Corso, G, Gilardi, L, Girardi, A, De Scalzi, A, Pagani, G, Rossi, E, Montagna, G, Veronesi, P, Pagan, E, Bagnardi, V, Grana, C, Corso, Giovanni, Gilardi, Laura, Girardi, Antonia, De Scalzi, Alessandra Margherita, Pagani, Gianmatteo, Rossi, Elisabetta Maria Cristina, Montagna, Giacomo, Veronesi, Paolo, Pagan, Eleonora, Bagnardi, Vincenzo, and Grana, Chiara Maria
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Background: To assess the clinical usefulness of serum tumor markers for early detection of distant breast cancer recurrence using FDG-PET/CT. Methods: We retrospectively analyzed 561 consecutive patients who underwent surgery for invasive primary breast cancer and had increased tumor markers (CA 15-3 and CEA) after completion of locoregional therapy. FDG-PET/CT data were reviewed for all cases. CA 15-3 and CEA were evaluated both in a continuous and in a quartile (Q) distribution. The Wilcoxon rank-sum test and logistic regression models were used to evaluate the association between increased tumor marker values and the presence (and type) of distant metastases. Results: The median value of CA 15-3 was 35.0 U/mL (IQR, 29.5-43.0) in cases where no distant metastases were detected, and it was 58.9 U/mL (IQR, 40.0-108.0) in cases where metastases were detected (p < 0.001). The median value of CEA was 6.6 U/mL (IQR, 4.4-10.0) in cases of no metastases and 12.4 U/mL (IQR, 6.9-30.0) in cases of metastases (p < 0.001). Increased levels of both tumor markers (Q3 and Q4) were strongly associated with the presence of distant metastases. The association between CA 15-3 and bone/liver metastases was stronger compared with other types of metastases (p heterogeneity between odds ratios [ORs] = 0.03 for Q3 and <0.001 for Q4), while no relevant heterogeneity between ORs emerged for CEA. Conclusion: Increased tumor marker levels detected in asymptomatic breast cancer patients during adjuvant therapies and follow-up are significantly predictive of distant metastases identified on FDG-PET/CT.
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- 2020
17. Intrafetal laser treatment for twin reversed arterial perfusion sequence: cohort study and meta-analysis
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Pagani, G., DʼAntonio, F., Khalil, A., Papageorghiou, A., Bhide, A., and Thilaganathan, B.
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- 2013
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18. Acromegaly is associated with increased cancer risk: a survey in Italy
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Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, FERRANTE, EMANUELE, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura, Lombardi, G., TRIMARCHI, LORENZO, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., Persani, L., Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, Ferrante, Emanuele, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura for the Italian Study Group of Acromegaly, Arosio, Maura, Lombardi, G., Trimarchi, Lorenzo, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., and Persani, L.
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,NO ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Neoplasms ,Internal medicine ,Gh IGF1 ,Acromegaly ,Humans ,Medicine ,cancer ,Family history ,Thyroid cancer ,Acromegaly cancer ,Oncology ,business.industry ,GH ,IGF1 ,acromegaly ,Incidence ,Risk Factor ,Incidence (epidemiology) ,Cancer ,Middle Aged ,medicine.disease ,Diabetes and Metabolism ,Acromegaly, cancer, GH, IGF1 ,Italy ,030220 oncology & carcinogenesis ,Neoplasm ,Female ,Cohort Studie ,business ,Kidney cancer ,Human ,Cohort study - Abstract
It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18–1.68, P P = 0.022), kidney cancer (SIR 2.87; 95% CI, 1.55–5.34, P P
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- 2017
19. Cervical-length measurement in mid-gestation to predict spontaneous preterm birth in asymptomatic triplet pregnancy
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Fichera, A., Pagani, G., Stagnati, V., Cascella, S., Faiola, S., Gaini, C., Lanna, M., Pasquini, L., Raffaelli, R., Stampalija, T., Tommasini, A., Prefumo, F., Fichera, A., Pagani, G., Stagnati, V., Cascella, S., Faiola, S., Gaini, C., Lanna, M., Pasquini, L., Raffaelli, R., Stampalija, T., Tommasini, A., and Prefumo, F.
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Adult ,Logistic Model ,triplet ,multiple pregnancy ,predictive test ,ultrasound cervical length ,Predictive Value of Test ,Gestational Age ,Retrospective Studie ,Predictive Value of Tests ,Pregnancy ,preterm birth ,triplets ,Female ,Humans ,Infant, Newborn ,Logistic Models ,Premature Birth ,Retrospective Studies ,Cervical Length Measurement ,Pregnancy, Triplet ,Infant ,Newborn ,cervical length ,Human - Abstract
To assess the predictive value of sonographic cervical-length (CL) measurement in mid-gestation for spontaneous preterm birth (PTB) in asymptomatic triplet pregnancy.This was a retrospective study of asymptomatic triplet pregnancies followed at five Italian tertiary referral centers, between 2002 and 2015. CL was measured transvaginally between 18 and 24 weeks' gestation. Pregnancies with medically indicated PTB were excluded. Demographic and pregnancy characteristics of pregnancies complicated by PTB were analyzed and the distributions of CL measurements in these patients were calculated. Logistic regression analysis was performed to assess the association between CL and PTB, adjusted for confounders. Performance of CL measurement in prediction of PTB 28, 30 and 32 weeks of gestation was assessed.A total of 120 triplet pregnancies were included in the final analysis. Median CL was 35 (interquartile range (IQR), 29-40) mm measured at a median gestational age of 20 + 2 (IQR, 20 + 0 to 23 + 4) weeks. Overall, 23 (19.2%), 17 (14.2%) and eight (6.7%) patients had a CL 25, 20 and 15 mm, respectively. Spontaneous PTB 32 weeks occurred in 41 (34.2%) cases, 30 weeks in 23 (19.2%) and 28 weeks in 12 (10%) cases. CL 15 mm was significantly more frequent in the group of patients who delivered 28 (P = 0.03) and 30 (P = 0.01) weeks' gestation, compared with those who delivered after 28 and after 30 weeks, respectively, while CL 20 mm was more common in triplet pregnancies with delivery 32 weeks compared with those delivered ≥ 32 weeks (P = 0.03). Logistic regression analysis was possible only for PTB 32 weeks due to the small number of cases that delivered 30 and 28 weeks. After adjustment for confounders, CL was not significantly associated with PTB 32 weeks (adjusted odds ratio, 0.97; 95% CI, 0.94-1.01). CL measurement had an area under the receiver-operating characteristics curve of 0.41 (95% CI, 0.20-0.62), 0.41 (95% CI, 0.26-0.56) and 0.42 (95% CI, 0.31-0.54) for the prediction of spontaneous PTB 28, 30 and 32 weeks, respectively.CL assessed in mid-gestation is a poor predictor of PTB 28, 30 and 32 weeks' gestation in asymptomatic triplet pregnancy. Copyright © 2017 ISUOG. Published by John WileySons Ltd.
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- 2016
20. Organic Electrochromic Polymers: State-of-the-Art Neutral Tint Multichromophoric Polymers for High-Contrast See-Through Electrochromic Devices (Adv. Funct. Mater. 29/2016)
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Sassi, M, Salamone, M, Ruffo, R, Patriarca, G, Mari, C, Pagani, G, Posset, U, Beverina, L, Sassi M., Salamone M. M., Ruffo R., Patriarca G. E., Mari C. M., Pagani G. A., Posset U., Beverina L., Sassi, M, Salamone, M, Ruffo, R, Patriarca, G, Mari, C, Pagani, G, Posset, U, Beverina, L, Sassi M., Salamone M. M., Ruffo R., Patriarca G. E., Mari C. M., Pagani G. A., Posset U., and Beverina L.
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- 2016
21. Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta‐analysis
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D'Antonio, F., primary, Odibo, A., additional, Berghella, V., additional, Khalil, A., additional, Hack, K., additional, Saccone, G., additional, Prefumo, F., additional, Buca, D., additional, Liberati, M., additional, Pagani, G., additional, and Acharya, G., additional
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- 2019
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22. Diagnostic accuracy of magnetic resonance imaging in detecting the severity of abnormal invasive placenta: a systematic review and meta-analysis
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Familiari, Alessandra, Liberati, M., Lim, P., Pagani, G., Cali, G., Buca, D., Manzoli, Lamberto, Flacco, M. E., Scambia, Giovanni, D'Antonio, Francesco, Familiari A. (ORCID:0000-0002-6353-9383), Manzoli L., Scambia G. (ORCID:0000-0003-2758-1063), D'antonio F., Familiari, Alessandra, Liberati, M., Lim, P., Pagani, G., Cali, G., Buca, D., Manzoli, Lamberto, Flacco, M. E., Scambia, Giovanni, D'Antonio, Francesco, Familiari A. (ORCID:0000-0002-6353-9383), Manzoli L., Scambia G. (ORCID:0000-0003-2758-1063), and D'antonio F.
- Abstract
Introduction: Accurate prenatal diagnosis of abnormally invasive placenta (AIP) is fundamental because it significantly reduces maternal morbidities. Material and methods: Medline, Embase, CINAHL and the Cochrane databases were searched. The primary aim of the present review was to elucidate the diagnostic accuracy of prenatal magnetic resonance imaging (MRI) in recognizing the severity of AIP, defined as the depth and topography of invasion. The secondary aim was to ascertain the strength of association between each MRI sign and the depth of placental invasion and to test their individual predictive accuracy in detecting such invasion. Inclusion criteria were studies on women who had prenatal MRI for ultrasound suspicion or the presence of clinical risk factors for AIP. Estimates of sensitivity, specificity, positive and negative likelihood ratios and diagnostic odds ratio were calculated using the hierarchical summary receiver characteristics curve model, and individual data random-effect logistic regression was used to calculate OR. Results: Twenty studies (1080 pregnancies undergoing MRI mainly for the ultrasound suspicion of AIP) were included. MRI showed a sensitivity of 94.4% [95% confidence interval (CI) 15.8–99.9], 100% (95% CI 75.3–100) and 86.5% (95% CI 74.2–94.4) for detection of placenta accreta, increta and percreta, respectively; the corresponding values for specificity were 98.8% (95% CI 70.7–100), 97.3% (95% CI 93.3–99.3), 96.8% (95% CI 93.5–98.7). MRI identified 100% of cases with S1 and 100% of those with S2 invasion confirmed at surgery. Among the different MRI signs, intra-placental dark bands showed the best sensitivity for the detection of placenta accreta, increta and percreta; as well as abnormal intra-placental vascularity, uterine bulging was associated with a higher risk of increta and percreta, exophitic mass and bladder tenting with placenta percreta. Conclusion: Prenatal MRI has an excellent diagnostic accuracy in identifying the depth
- Published
- 2018
23. Transfer-based models implementation in an equation oriented package
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Pagani, G., d'Arminio Monforte, A., and Bianchi, G.
- Published
- 2001
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24. Cervical‐length measurement in mid‐gestation to predict spontaneous preterm birth in asymptomatic triplet pregnancy
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Fichera, A., primary, Pagani, G., additional, Stagnati, V., additional, Cascella, S., additional, Faiola, S., additional, Gaini, C., additional, Lanna, M., additional, Pasquini, L., additional, Raffaelli, R., additional, Stampalija, T., additional, Tommasini, A., additional, and Prefumo, F., additional
- Published
- 2018
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25. Evaluation of different enzymes as catalysts for the production of β-lactam antibiotics following a kinetically controlled strategy
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Hernández-Jústiz, O, Terreni, M, Pagani, G, Garcı́a, J.L, Guisán, J.M, and Fernández-Lafuente, R
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- 1999
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26. The METABOLIC Study: Multidimensional assessment of health and functional status in older patients with type 2 diabetes taking oral antidiabetic treatment
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Maggi, S., Noale, M., Pilotto, A., Tiengo, A., Cavallo Perin, P., Crepaldi, G., Metabolic Working Group Collaborators:, Andrea C., Aglioloro, A., Allochis, G., Arico, C. N., Balbo, M., Marangoni, A., Balzano, S., Battisti, B., Testa, I., Brandoni, G., Bruno, A., Degiovanni, M., Buzzetti, Raffaella, Foffi, C., Calatola, P., Cantarella, S. A., Rondena, M., Cimpanelli, M. G., Confortin, L., Consoli, A., Baldassarre, M., Invitti, C., Conti, A., Del Prato, S., Crisci, I., Derosa, G., Maffioli, P., Devangelio, E., Di Bartolo, P., Ruggeri, P., Di Lembo, S., Di Mauro, M., Battiato, R., Farci, F., Fisicaro, M., Pontiroli, A., Folini, L., Gargiulo, A., Vinciguerra, A., Giorgino, F., Laviola, L., Clementina, C., Guerini, S., Tonolo, G., Iwaniszyn, D., Lambiase, C., Leotta, S., Mangeri, F., Mangili, R., Mattiuzzo, C., Mollo, F., Novara, F., Gucciardi, P., Orsi, E., Palmieri, E., Pacifico, A. A., Burruni, A., Pagani, G., Albizzi, M., Pasquini, C., Cavallo, P. P., Perotto, M., Piccolo, P., D'Ambrosio, P., Maolo, G., Polenta, B., Purrello, F., Tomaselli, T., Tardio, M. S., Quarantelli, C., Ragusa, G. S., Borzi, V., Rapisardi, R., Richini, D., Rosco, M., Serra, R., Marchesini, R. G., Soverini, V., Tomasi, F., De Angelis, M., Turco, A., Tolaini, P., Vangucci, S., and Zavaroni, I.
- Subjects
Male ,Drug ,medicine.medical_specialty ,Activities of daily living ,Health Status ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,media_common.quotation_subject ,Administration, Oral ,Type 2 diabetes ,Cohort Studies ,Diabetes Complications ,Endocrinology ,Surveys and Questionnaires ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,Humans ,Hypoglycemic Agents ,Medicine ,Metabolic study ,Aged ,media_common ,Aged, 80 and over ,business.industry ,Insulin ,Age Factors ,General Medicine ,medicine.disease ,Hypoglycemia ,Malnutrition ,Diabetes Mellitus, Type 2 ,Physical therapy ,Female ,business ,Cohort study - Abstract
Aim The objective of the METABOLIC Study was to evaluate overall health status, with particular focus on assessment of functional status of older patients taking oral antidiabetic drug (OAD) treatment. Methods The study included 1342 type 2 diabetes patients aged ≥ 65 years treated with OADs, with or without insulin, who had been referred to outpatients clinics across Italy. Information on diabetes (duration, medications taken during the last 3 months, hypoglycaemic events and diabetic complications) was collected by questionnaire, and the patients’ overall health status was assessed using a multidimensional prognostic index. Results The sample recruited (mean age: 73.3 ± 5.5 years) had a mean duration of diabetes of 11.3 ± 8.2 years. Half were taking sulphonylureas alone or together with other medications, 9.7% were taking insulin in combination with other OADs, almost 30% were using biguanides and 6.2% were taking dipeptidyl peptidase-4 (DPP-4) inhibitors. Also, 12% of patients reported hypoglycaemic events, 90% of whom were taking insulin or sulphonylureas. In addition, 81% of the participants were completely independent in their activities of daily living, while 19% were mildly, moderately or severely disabled. Age, female gender, hypoglycaemic events, neuropathy and low diastolic blood pressure were the main variables associated with disability. Conclusion Disability is common in older diabetic patients and some associated factors, such as hypoglycaemia and low diastolic blood pressure, have been identified. Also identified was malnutrition as a specific factor associated with hypoglycaemic events independent of the use of insulin and sulphonylureas.
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- 2013
27. Early prediction of twin-to-twin transfusion syndrome: systematic review and meta-analysis
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Stagnati, V, Zanardini, C, Fichera, A, Pagani, G, Quintero, R, Bellocco, R, Prefumo, F, BELLOCCO, RINO, Prefumo, F., Stagnati, V, Zanardini, C, Fichera, A, Pagani, G, Quintero, R, Bellocco, R, Prefumo, F, BELLOCCO, RINO, and Prefumo, F.
- Abstract
Objective: To assess the role of first- and early second-trimester markers in the prediction of twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies. Methods: Electronic databases MEDLINE, EMBASE and ClinicalTrials.gov were searched from inception to April 2014, using the MeSH term ‘fetofetal transfusion’ in combination with phrases ‘predictive value’, ‘sensitivity’, ‘specificity’, ‘false positive’, ‘false negative’, ‘screening’, ‘accuracy’ and ‘ROC’. Study quality was assessed using the PRISMA guidelines and QUADAS-2 tool. A meta-analysis was planned for the following predictive factors: intertwin nuchal translucency (NT) discrepancy; NT > 95th percentile in at least one twin; intertwin crown–rump length (CRL) discrepancy as a percentage of the larger CRL; abnormal ductus venosus (DV) flow in at least one twin. The outcome assessed was TTTS, defined according to the presence of a twin oligohydramnios–polyhydramnios sequence. The diagnostic performance of the predictive factors was evaluated for each included study. Results: The electronic search identified 152 records, of which 23 were assessed in full for eligibility. We identified 13 eligible studies that reported the predictive accuracy of ultrasound parameters, measured before 16 weeks, for the development of TTTS, including a total of 1991 pregnancies, of which 323 developed TTTS. An increased risk of TTTS was associated with: intertwin NT discrepancy (positive likelihood ratio (LR+), 1.92 (95% CI, 1.25–2.96); negative likelihood ratio (LR–), 0.65 (95% CI, 0.50–0.84)); NT > 95th percentile (LR+, 2.63 (95% CI, 1.51–4.58); LR–, 0.85 (95% CI, 0.75–0.96)); CRL discrepancy > 10% (LR+, 1.80 (95% CI, 1.05–3.07); LR–, 0.92 (95% CI, 0.81–1.05)); abnormal DV flow (LR+, 4.77 (95% CI, 1.33–17.04; LR–, 0.49 (95% CI, 0.17–1.41)). The highest sensitivities were observed for intertwin NT discrepancy (52.8% (95% CI, 43.8–61.7%)) and abnormal DV flow (50.0% (95% CI, 33.4–66.6%)). Conclusion: Monochorionic
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- 2017
28. Session 23. Reproductive endocrinology
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Mattei, A.M., Cavioni, V., testa, G., Zaro, A., Crosignani, P.G., Webster, J., Scalon, M.F., D'Alberton, A., Falsetti, L., Ferrari, C., Fioretti, P., Giordano, G., L'Hermite, M., Camanni, F., De Cecco, L., Fadini, R., Faglia, G., Flamigni, F., Tamburrano, G., Pedroncelli, A., Montini, M., Pagani, G., Pagani, M.D., Gianola, D., Tengattini, F., Cortesi, L., Gherardi, F., Sileo, F., Lancranjanl, I., Pasinetti, E., Gastaldi, A., Bertazzoli, M., Broglio, Grabinski, Simionato, S., Lucianetti, M., Miragoli, A., Braat, D.D.M., Schoemaker, J., Mazzocchi, N., Lepore, G., Cedard, L., Mignot, Th.M., Meunier, K., Maria, A., Guichard, A., Boyer, P., Zorn, J.R., Mattei, A.M., Cavioni, V., testa, G., Zaro, A., Crosignani, P.G., Webster, J., Scalon, M.F., D'Alberton, A., Falsetti, L., Ferrari, C., Fioretti, P., Giordano, G., L'Hermite, M., Camanni, F., De Cecco, L., Fadini, R., Faglia, G., Flamigni, F., Tamburrano, G., Pedroncelli, A., Montini, M., Pagani, G., Pagani, M.D., Gianola, D., Tengattini, F., Cortesi, L., Gherardi, F., Sileo, F., Lancranjanl, I., Pasinetti, E., Gastaldi, A., Bertazzoli, M., Broglio, Grabinski, Simionato, S., Lucianetti, M., Miragoli, A., Braat, D.D.M., Schoemaker, J., Mazzocchi, N., Lepore, G., Cedard, L., Mignot, Th.M., Meunier, K., Maria, A., Guichard, A., Boyer, P., and Zorn, J.R.
- Published
- 2017
29. Outcome of fetal ovarian cysts diagnosed on prenatal ultrasound examination: systematic review and meta-analysis
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Bascietto, F, Liberati, M, Marrone, L, Khalil, A, Pagani, G, Gustapane, S, Leombroni, M, Buca, D, Flacco, ME, Rizzo, G, Acharya, G, Manzoli, L, and D'Antonio, F
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Ovarian Cysts ,Economica ,fetal ovarian torsion, outcome ,ovarian cysts, ultrasound ,ultrasound ,Predictive Value of Tests ,Pregnancy ,outcome ,Socio-culturale ,Humans ,fetal ovarian torsion ,Female ,Ultrasonography, Prenatal - Abstract
To explore the outcome of fetuses with a prenatal diagnosis of ovarian cyst.The electronic databases MEDLINE and EMBASE were searched using keywords and word variants for 'ovarian cysts', 'ultrasound' and 'outcome'. The following outcomes in fetuses with a prenatal diagnosis of ovarian cyst were explored: resolution of the cyst, change of ultrasound pattern of the cyst, occurrence of ovarian torsion and intracystic hemorrhage, need for postnatal surgery, need for oophorectomy, accuracy of prenatal ultrasound examination in correctly identifying ovarian cyst, type of ovarian cyst at histopathological analysis and intrauterine treatment. Meta-analyses using individual data random-effects logistic regression and meta-analyses of proportions were performed. Quality assessment of the included studies was performed using the Newcastle-Ottawa Scale.Thirty-four studies (954 fetuses) were included. In 53.8% (95% CI, 46.0-61.5%) of cases for which resolution of the cyst was evaluated (784 fetuses), the cyst regressed either during pregnancy or after birth. The likelihood of resolution was significantly lower in complex vs simple cysts (odds ratio (OR), 0.15 (95% CI, 0.10-0.23)) and in cysts measuring ≥ 40 mm vs 40 mm (OR, 0.03 (95% CI, 0.01-0.06)). Change in ultrasound pattern of the cyst was associated with an increased risk of ovarian loss (surgical removal or autoamputation) (pooled proportion, 57.7% (95% CI, 42.9-71.8%)). The risk of ovarian torsion was significantly higher for cysts measuring ≥ 40 mm compared with 40 mm (OR, 30.8 (95% CI, 8.6-110.0)). The likelihood of having postnatal surgery was higher in patients with cysts ≥ 40 mm compared with 40 mm (OR, 64.4 (95% CI, 23.6-175.0)) and in complex compared with simple cysts, irrespective of cyst size (OR, 14.6 (95% CI, 8.5-24.8)). In cases undergoing prenatal aspiration of the cyst, rate of recurrence was 37.9% (95% CI, 14.8-64.3%), ovarian torsion and intracystic hemorrhage were diagnosed after birth in 10.8% (95% CI, 4.4-19.7%) and 12.8% (95% CI, 3.8-26.0%), respectively, and 21.8% (95% CI, 0.9-40.0%) had surgery after birth.Size and ultrasound appearance are the major determinants of perinatal outcome in fetuses with ovarian cysts. Copyright © 2016 ISUOG. Published by John WileySons Ltd.
- Published
- 2016
30. Cervical length measurement at mid-gestation to predict spontaneous preterm birth in triplet pregnancies
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Fichera, A., Pagani, G., Stagnati, V., Cascella, Sara, Faiola, S., Gaini, C., Lanna, M., Pasquini, L., Raffaelli, Ricciarda, Stampalija, T., Tommasini, A., and Prefumo, F.
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triplet pregnancies ,triplet pregnancy, preterm birth, cervical length ,triplet pregnancy ,preterm birth ,cervical length - Published
- 2016
31. Outcome of fetal ovarian cysts diagnosed on prenatal ultrasound examination: systematic review and meta-analysis
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Bascietto, F., primary, Liberati, M., additional, Marrone, L., additional, Khalil, A., additional, Pagani, G., additional, Gustapane, S., additional, Leombroni, M., additional, Buca, D., additional, Flacco, M. E., additional, Rizzo, G., additional, Acharya, G., additional, Manzoli, L., additional, and D'Antonio, F., additional
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- 2017
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32. Early prediction of twin‐to‐twin transfusion syndrome: systematic review and meta‐analysis
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Stagnati, V., primary, Zanardini, C., additional, Fichera, A., additional, Pagani, G., additional, Quintero, R. A., additional, Bellocco, R., additional, and Prefumo, F., additional
- Published
- 2017
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33. Tools to differentiate medium-high versus medium low-care intensity in an Internal Medecine Unit
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Mangia, M, Casati, M, Carobbio, A, Caldara, R, Morandi, I, Cattaneo, M, Senni, M, Pagani, G, Ghidoni, S, Tiraboschi, P, Galbiati, G, Capelli, C, Tomasoni, L, Cesa, S, Brucato, A, Mangia M, Casati M, Carobbio A, Caldara R, Morandi I, Cattaneo M, Senni M, Pagani G, Ghidoni S, Tiraboschi P, Galbiati G, Capelli C, Tomasoni L, Cesa S, Brucato A, Mangia, M, Casati, M, Carobbio, A, Caldara, R, Morandi, I, Cattaneo, M, Senni, M, Pagani, G, Ghidoni, S, Tiraboschi, P, Galbiati, G, Capelli, C, Tomasoni, L, Cesa, S, Brucato, A, Mangia M, Casati M, Carobbio A, Caldara R, Morandi I, Cattaneo M, Senni M, Pagani G, Ghidoni S, Tiraboschi P, Galbiati G, Capelli C, Tomasoni L, Cesa S, and Brucato A
- Published
- 2011
34. Perinatal mortality, timing of delivery and prenatal management of monoamniotic twin pregnancy: systematic review and meta-analysis.
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Acharya, G., D'Antonio, F., Buca, D., Liberati, M., Pagani, G., D'Antonio, Francesco, Acharya, Ganesh, Odibo, Anthony, Berghella, Vincenzo, Khalil, Asma, Hack, Karien, Saccone, Gabriele, Prefumo, Federico, Buca, Danilo, Liberati, Marco, Pagani, Giorgio, Odibo, A., Berghella, V., Khalil, A., and Hack, K.
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PERINATAL care ,FETOFETAL transfusion ,CINAHL database ,INFANT mortality ,MEDICAL information storage & retrieval systems ,MATERNAL health services ,MEDLINE ,META-analysis ,MULTIPLE pregnancy ,TWINS ,SYSTEMATIC reviews - Abstract
Copyright of Ultrasound in Obstetrics & Gynecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
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35. State-of-the-Art Neutral Tint Multichromophoric Polymers for High-Contrast See-Through Electrochromic Devices
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Sassi, M, Salamone, M, Ruffo, R, Patriarca, G, Mari, C, Pagani, G, Posset, U, Beverina, L, SASSI, MAURO, SALAMONE, MATTEO MARCO, RUFFO, RICCARDO, PATRIARCA, GIORGIO EMANUELE, MARI, CLAUDIO MARIA, BEVERINA, LUCA, Sassi, M, Salamone, M, Ruffo, R, Patriarca, G, Mari, C, Pagani, G, Posset, U, Beverina, L, SASSI, MAURO, SALAMONE, MATTEO MARCO, RUFFO, RICCARDO, PATRIARCA, GIORGIO EMANUELE, MARI, CLAUDIO MARIA, and BEVERINA, LUCA
- Abstract
Two new multichromophoric electrochromic polymers featuring a conjugated EDOT/ProDOT copolymer backbone (PXDOT) and a reversible Weitz-type redox active small molecule electrochrome (WTE) tethered to the conjugated chain are reported here. The careful design of the WTEs provides a highly reversible redox behavior with a colorless red switching that complements the colorless blue switching of the conjugated backbone. Subtractive color mixing successfully provides high performing solution processable polymeric layers with colorless neutral tint switchable limiting states for application in see-through electrochromic devices. Design, synthesis, comprehensive chemical and spectroelectrochemical characterization as well as the preparation of a proof-of-concept device are discussed.
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- 2016
36. Multichromophoric Electrochromic Polymers toward High Contrast Neutral Tint See-Through Electrochromic Devices
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Sassi, M, Salamone, M, Ruffo, R, Patriarca, G, Mari, C, Pagani, G, Posset, U, Beverina, L, SASSI, MAURO, SALAMONE, MATTEO MARCO, RUFFO, RICCARDO, PATRIARCA, GIORGIO EMANUELE, MARI, CLAUDIO MARIA, BEVERINA, LUCA, Pagani, GA, Sassi, M, Salamone, M, Ruffo, R, Patriarca, G, Mari, C, Pagani, G, Posset, U, Beverina, L, SASSI, MAURO, SALAMONE, MATTEO MARCO, RUFFO, RICCARDO, PATRIARCA, GIORGIO EMANUELE, MARI, CLAUDIO MARIA, BEVERINA, LUCA, and Pagani, GA
- Abstract
Organic electrochromic materials (OEMs) offer a low power input and low cost solution for see-through shading applications (i.e. smart windows, sunglasses). Relevant see-through applications for transmissive ECDs, like sunglasses and automotive, additionally require that the transmitted light experiences negligible colour distortion in both devices limiting states. Donor-Acceptor (DA) polymers concept and all-donor copolymers blends partially addressed this very challenging topic.[1-2] The latter strategy provided brown neutral hues with high bleached state transmissivities (T~70%). These performances are still far from those required to enable a functional assembled electrochromic device (ECD) to compare with existing benchmark technologies (i.e. photochromic lenses). Multichromophoric conjugated polymers (MCPs), are a viable alternative to both DA polymers and polymer blends. These are conjugated polymers (i.e. PEDOT) bearing discrete electrochromic single molecules as side chain substituents acting as contrast enhancers and color tuning additives. Most relevant advantages are an easy synthetic access, colour tunability, superior electrochromic contrast and exceptionally high transmissivity of the colourless state. We here present the design, synthesis, polymerization and full electrochemical and spectroelectrochemical characterization of a series of new electrochromic MCPs based upon specifically designed DE pertaining to the class of Weitz electrochromes (WTE). The obtained polymeric films are able to reversibly switch between a brown and a colourless limiting states. The superior optical performances combine state-of-the-art lightness contrast with neutral hue, and a unique high lightness colourless state (L* 94, S ab 2) that make this material an ideal candidate for application in transmissive ECDs. A proof-of-concept ECD using PB at the counterelectrode show state-of-the-art performance, combining a high lightness low saturation bleached state (L* 83, Sab 4)
- Published
- 2016
37. Indagine di popolazione sugli stili di vita in relazione alla salute nel territorio della ASL – Provincia di Milano 3
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Bonazzi, M, Colzani, E, DEL CORNO, G, Canini, S, Colombo, A, Agozzino, F, Crippa, L, Pagani, G, BONAZZI, MARIA CHIARA, COLZANI, EDOARDO, DEL CORNO, GIAN GIUSEPPE, Pagani, G., Bonazzi, M, Colzani, E, DEL CORNO, G, Canini, S, Colombo, A, Agozzino, F, Crippa, L, Pagani, G, BONAZZI, MARIA CHIARA, COLZANI, EDOARDO, DEL CORNO, GIAN GIUSEPPE, and Pagani, G.
- Published
- 2008
38. Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group
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Menis, E., Giustina, A., Colao, A., Degli Uberti, E., Ghigo, E., Minuto, F., Bogazzi, F., Drigo, R., Cattaneo, A., Aimaretti, G., Ambrosio, M. R., Andreani, M., Angeletti, G., Celleno, R., Appetecchia, M. L., Baldelli, R., Armigliato, M., Arosio, M., Babini, A., Baldi, F., Balza, G., Bartalena, L., Tanda, M. L., Battista, C., Beck-Peccoz, P., Boffano, G. M., Martino, E., Borboni, P., Borretta, G., Baffoni, C., Boscaro, M., Arnaldi, G., Buschini, M., Salvatore Cannavo, Caramellino, A., Carani, C., Castelli, A., Pancotti, M., Cavagnini, F., Chiodera, P., Cataldo, S., Chiovato, L., Colombo, M., Crivellaro, C., D Ulizia, M., Mattè, S., Del Monte, P., Delitala, G., Masala, A., Fabbri, A., Piantoni, L., Faustini Fustini, M., Favro, S., Ferone, D., Fidotti, E., Valentini, F., Formoso, G., Frigato, F., Furlani, L., Gargiulo, P., Gasparoni, P., Gazzaruso, C., Giordano, C., Giorgino, F., Grandi, M., Pedersoli, S., Grimaldi, F., Grottoli, S., La Grotta, A., Lanzi, R., Limone, P., Razzore, P., Lio, S., Lo Cascio, V., Francia, G., Davì, M. V., Lo Coco, R., Macinini, E., Mantero, F., Scaroni, C., Marchetti, M., Mariotti, S., Pigliaru, F., Marzullo, P., Monachesi, M., Montini, M., Pagani, G., Muggeo, M., Castello, R., Mulas, G., Nassi, R., Vezzosi, C., Nizzoli, M., Orlandi, F., Pacini, F., Di Cairano, G., Palermo, M., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pagotto, U., Pavoncello, S., Perego, M. R., Peri, A., Piscopello, L., Pivonello, R., Raffa, M., Raggiunti, B., Roiter, I., Tamburrano, G., Terzolo, M., Testa, I., Testori, G., Cerruti, N., Toscano, V., Tota, N., Vailati, A., Lovati, E., Valcavi, R., Vincenzi, V., De Menis, E, Giustina, A, Colao, A, Degli Uberti, E, Ghigo, E, Minuto, F, Bogazzi, F, Drigo, R, Cattaneo, A, Aimaretti, G, Giordano, C, Giustina, Andrea, Italian Study Group, C. O. M. E. T. A., De Menis, E., Giustina, A., Colao, A., Degli Uberti, E., Ghigo, E., Minuto, F., Bogazzi, F., Drigo, R., Cattaneo, A., Aimaretti, G., Ambrosio, M.R., Andreani, M., Angeletti, G., Celleno, R., Appetecchia, M.L., Baldelli, R., Armigliato, M., Arosio, M., Babini, A., Baldi, F., Balza, G., Bartalena, L., Tanda, M.L., Battista, C., Beck-Peccoz, P., Boffano, G.M., Martino, E., Borboni, P., Borretta, G., Baffoni, C., Boscaro, M., Arnaldi, G., Buschini, M., Cannavò, S., Caramellino, A., Carani, C., Castelli, A., Pancotti, M., Cavagnini, F., Chiodera, P., Cataldo, S., Chiovato, L., Colombo, M., Crivellaro, C., D'Ulizia, M., De Mattè, S., Del Monte, P., Delitala, G., Masala, A., Fabbri, A., Piantoni, L., Faustini Fustini, M., Favro, S., Ferone, D., Fidotti, E., Valentini, F., Formoso, G., Frigato, F., Furlani, L., Gargiulo, P., Gasparoni, P., Gazzaruso, C., Giordano, C., Giorgino, F., Grandi, M., Pedersoli, S., Grimaldi, F., Grottoli, S., La Grotta, A., Lanzi, R., Limone, P., Razzore, P., Lio, S., Lo Cascio, V., Francia, G., Davì, M.V., Lo Coco, R., Macinini, E., Mantero, F., Scaroni, C., Marchetti, M., Mariotti, S., Pigliaru, F., Marzullo, P., Monachesi, M., Montini, M., Pagani, G., Muggeo, M., Castello, R., Mulas, G., Nassi, R., Vezzosi, C., Nizzoli, M., Orlandi, F., Pacini, F., Di Cairano, G., Palermo, M., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pagotto, U., Pavoncello, S., Perego, M.R., Peri, A., Piscopello, L., Pivonello, R., Raffa, M., Raggiunti, B., Roiter, I., Tamburrano, G., Terzolo, M., Testa, I., Testori, G., Cerruti, N., Toscano, V., Tota, N., Vailati, A., Lovati, E., Valcavi, R., Vincenzi, V., Colao, Annamaria, and C. O. M. E. T. A. Italian Study G. r. o. u., P.
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Polysomnography ,Comorbidity ,somatostatin analogs ,acromegaly ,sleep apnea syndrome ,Settore MED/13 - Endocrinologia ,Somatostatin analog ,Endocrinology ,Sleep Apnea Syndromes ,Quality of life ,Acromegaly ,Sleep apnea syndrome ,Somatostatin analogs ,Physicians ,Surveys and Questionnaires ,medicine ,Prevalence ,Humans ,Continuous positive airway pressure ,medicine.diagnostic_test ,business.industry ,Sleep apnea ,Awareness ,Focus Groups ,sleep apnea ,medicine.disease ,Sleep Apnea ,Italy ,Physical therapy ,COM.E.TA ,Female ,Clinical Competence ,business - Abstract
In 2007 the Italian COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) study group started to assess the application in a clinical setting of the Versailles criteria for management of acromegaly complications by a first questionnaire focusing on cardiovascular co-morbidities. A further questionnaire on sleep apnea syndrome (SAS) was delivered by the COM.E.T.A. study group to 107 endocrine centers in Italy. The results of our survey suggest that SAS is a well-known comorbidity even if its estimated prevalence is lower than in the literature. Polysomnography is the preferred tool for diagnosis. Control of SAS is considered relevant both for quality of life and co-morbidities. Continuous positive airway pressure is the cornerstone of therapy, but patients' acceptance may be critical. Control of GH/IGF-I secretion is important to improve SAS. Management of SAS requires cooperation between specialists. ©2011, Editrice Kurtis.
- Published
- 2011
39. The Smart Grid's Data Generating Potentials
- Author
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Aiello, M., Pagani, G. A., Ganzha, M., Maciaszek, L., Paprzycki, M., and Distributed Systems
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Data grid ,business.industry ,Computer science ,Test data generation ,Big data ,Computer security ,computer.software_genre ,Grid ,Electric power system ,Semantic grid ,Smart grid ,Grid computing ,business ,computer - Abstract
The Smart Grid is the vision underlying the evolution the power grid is currently undergoing. Its pillars are increased efficiency, self-healing, operation automation, and renewable energy integration obtained through real-time control and digitalization of the infrastructure. Thus, an important ingredient—if not the main one—is information technology support for power transmission and distribution. Given the size of the power grid, its pervasiveness, and the need for its availability, it is easy to imagine that any serious ICT infrastructure dealing with it will have to manage a great deal of rapidly forming data. Now the question is whether the amount, diversity, and uses of such data put the smart grid in the category of Big Data applications, followed by the natural question of what is the value of such data. To provide an initial answer to this question, we analyze the current state of data generation of the Dutch grid, its evolution towards a smart grid, and a future realistic scenario. The scenario considered shows that the amount of data generated is comparable to some of today's social media and “classic” Big Data examples.
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- 2014
40. OP07.07: Outcome in fetuses with isolated agenesis of the corpus callosum: a systematic review and meta‐analysis
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D'Antonio, F., primary, Pagani, G., additional, Familiari, A., additional, Khalil, A., additional, Malinger, G., additional, Lerman‐Sagie, T., additional, Leibovitz, Z., additional, Pilu, G., additional, Papageorghiou, A.T., additional, Garel, C., additional, Moutard, M., additional, and Prefumo, F., additional
- Published
- 2016
- Full Text
- View/download PDF
41. OP17.07: Cervical length measurement at mid‐gestation to predict spontaneous preterm birth in triplet pregnancies
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Fichera, A., primary, Pagani, G., additional, Stagnati, V., additional, Cascella, S., additional, Faiola, S., additional, Gaini, C., additional, Lanna, M., additional, Pasquini, L., additional, Raffaelli, R., additional, Stampalija, T., additional, Tommasini, A., additional, and Prefumo, F., additional
- Published
- 2016
- Full Text
- View/download PDF
42. OC24.03: Outcome of fetal ovarian cysts: a systematic review and meta‐analysis
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Bascietto, F., primary, Leombroni, M., additional, Liberati, M., additional, Marrone, L., additional, Pagani, G., additional, Khalil, A., additional, Gustapane, S., additional, Buca, D., additional, Giacci, F., additional, Rizzo, G., additional, Acharya, G., additional, and D'Antonio, F., additional
- Published
- 2016
- Full Text
- View/download PDF
43. Cervical length at mid-gestation in screening for preterm birth in twin pregnancy
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Pagani, G., primary, Stagnati, V., additional, Fichera, A., additional, and Prefumo, F., additional
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- 2016
- Full Text
- View/download PDF
44. Intertwin discrepancy in middle cerebral artery peak systolic velocity and third-trimester fetal growth restriction in monochorionic-diamniotic twin pregnancy
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Stagnati, V., primary, Pagani, G., additional, Fichera, A., additional, and Prefumo, F., additional
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- 2016
- Full Text
- View/download PDF
45. Novel heterocycle-based two-photon absorbing dyes
- Author
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Abbotto A., Beverina L., Bozio R., Bradamante S., Facchetti A., Ferrante C., Pagani G. A., Pedron D., Signorini R., Abbotto, A, Beverina, L, Bozio, R, Bradamante, S, Facchetti, A, Ferrante, C, Pagani, G, Pedron, D, and Signorini, R
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NLO, dyes - Published
- 2003
46. Passeggiando lungo la ferrovia decauville di una miniera ottocentesca: il trattamento idrometallurgico dei minerali a basso tenore di rame / il metodo Conedera
- Author
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Casini, A., Costantini, Armando, and Pagani, G.
- Published
- 2013
47. Phenotypic spectrum and prevalence of INPP5E mutations in Joubert Syndrome and related disorders
- Author
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Lorena, Travaglini, Francesco, Brancati, Jennifer, Silhavy, Miriam, Iannicelli, Elizabeth, Nickerson, Nadia, Elkhartoufi, Eric, Scott, Emily, Spencer, Stacey, Gabriel, Sophie, Thomas, Bruria, Ben Zeev, Enrico, Bertini, Eugen, Boltshauser, Malika, Chaouch, Maria, Roberta Cilio, Mirjam, M. de Jong, Hulya, Kayserili, Gonul, Ogur, Andrea, Poretti, Sabrina, Signorini, Graziella, Uziel, Maha, S. Zaki, Ali Pacha, L, Zankl, A, Leventer, R, Grattan Smith, P, Janecke, A, Koch, J, Freilinger, M, D'Hooghe, M, Sznajer, Y, Vilain, C, Van Coster, R, Demerleir, L, Dias, K, Moco, C, Moreira, A, Ae Kim, C, Maegawa, G, Dakovic, I, Loncarevic, D, Mejaski Bosnjak, V, Petkovic, D, Abdel Salam GM, Abdel Aleem, A, Marti, I, Pinard, Jm, Quijano Roy, S, Sigaudy, S, de Lonlay, P, Romano, S, Verloes, A, Touraine, R, Koenig, M, Dollfus, H, Flori, E, Fradin, M, Lagier Tourenne, C, Messer, J, Collignon, P, Penzien, Jm, Bussmann, C, Merkenschlager, A, Philippi, H, Kurlemann, G, Grundmann, K, Dacou Voutetakis, C, Kitsiou Tzeli, S, Pons, R, Jerney, J, Halldorsson, S, Johannsdottir, J, Ludvigsson, P, Phadke, Sr, Girisha, Km, Doshi, H, Udani, V, Kaul, M, Stuart, B, Magee, A, Spiegel, R, Shalev, S, Mandel, H, Lev, D, Michelson, M, Idit, M, Ben Zeev, B, Gershoni Baruch, R, Ficcadenti, A, Fischetto, R, Gentile, M, Della Monica, M, Pezzani, M, Graziano, C, Seri, M, Benedicenti, F, Stanzial, F, Borgatti, R, Romaniello, R, Accorsi, P, Battaglia, S, Fazzi, E, Giordano, L, Pinelli, L, Boccone, L, Barone, R, Sorge, G, Briatore, E, Bigoni, S, Ferlini, A, Donati, Ma, Biancheri, R, Caridi, G, Divizia, Mt, Faravelli, F, Ghiggeri, G, Mirabelli, M, Pessagno, A, Rossi, A, Uliana, V, Amorini, M, Briguglio, M, Briuglia, S, Salpietro, Cd, Tortorella, G, Adami, A, Bonati, Mt, Castorina, P, D'Arrigo, S, Lalatta, F, Marra, G, Moroni, I, Pantaleoni, C, Riva, D, Scelsa, B, Spaccini, L, Del Giudice, E, Ludwig, K, Permunian, A, Suppiej, A, Macaluso, C, Pichiecchio, A, Battini, R, Di Giacomo, M, Priolo, M, Timpani, P, Pagani, G, Di Sabato ML, Emma, F, Leuzzi, V, Mancini, F, Majore, S, Micalizzi, A, Parisi, P, Romani, M, Stringini, G, Zanni, G, Ulgheri, L, Pollazzon, M, Renieri, Alessandra, Belligni, E, Grosso, E, Pieri, I, Silengo, M, Devescovi, R, Greco, D, Romano, C, Cazzagon, M, Simonati, A, Al Tawari AA, Bastaki, L, Mégarbané, A, Sabolic Avramovska, V, Said, E, Stromme, P, Koul, R, Rajab, A, Azam, M, Barbot, C, Salih, Ma, Tabarki, B, Jocic Jakubi, B, Martorell Sampol, L, Rodriguez, B, Pascual Castroviejo, I, Gener, B, Puschmann, A, Starck, L, Capone, A, Lemke, J, Fluss, J, Niedrist, D, Hennekam, Rc, Wolf, N, Gouider Khouja, N, Kraoua, I, Ceylaner, S, Teber, S, Akgul, M, Anlar, B, Comu, S, Kayserili, H, Yüksel, A, Akcakus, M, Caglayan, Ao, Aldemir, O, Al Gazali, L, Sztriha, L, Nicholl, D, Woods, Cg, Bennett, C, Hurst, J, Sheridan, E, Barnicoat, A, Hemingway, C, Lees, M, Wakeling, E, Blair, E, Bernes, S, Sanchez, H, Clark, Ae, Demarco, E, Donahue, C, Sherr, E, Hahn, J, Sanger, Td, Gallager, Te, Daugherty, C, Krishnamoorthy, Ks, Sarco, D, Walsh, Ca, Mckanna, T, Milisa, J, Chung, Wk, De Vivo DC, Raynes, H, Schubert, R, Seward, A, Brooks, Dg, Goldstein, A, Caldwell, J, Finsecke, E, Maria, Bl, Holden, K, Cruse, Rp, Karaca, E, Swoboda, Kj, Viskochil, D, Dobyns, Wb, Colin, Johnson, Tania, Attié Bitach, Joseph, G. Gleeson, Enza, Maria Valente, ANS - Amsterdam Neuroscience, APH - Amsterdam Public Health, Human Genetics, Paediatrics, OMÜ, University of Zurich, Valente, Enza Maria, Fluss, Joel Victor, Travaglini, L, Brancati, F, Silhavy, J, Iannicelli, M, Nickerson, E, Elkhartoufi, N, Scott, E, Spencer, E, Gabriel, S, Thomas, S, Ben Zeev, B, Bertini, E, Boltshauser, E, Chaouch, M, Cilio, Mr, de Jong, Mm, Kayserili, H, Ogur, G, Poretti, A, Signorini, S, Uziel, G, Zaki, M, Johnson, C, Atti? Bitach, T, Gleeson, Jg, Valente, Em, International JSRD Study, Group, and DEL GIUDICE, Ennio
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Male ,Ciliata -- Anatomy ,Proband ,10039 Institute of Medical Genetics ,Meckel syndrome ,RPGRIP1L ,Syndromes ,INPP5E ,MODIFIER ,Phosphoric Monoester Hydrolases/genetics ,Ciliopathies ,Polycystic Kidney Diseases/diagnosis/genetics ,CILIUM ,0302 clinical medicine ,Gene Frequency ,Cerebellum ,Prenatal Diagnosis ,RETINAL DEGENERATION ,Prevalence ,MECKEL ,ciliopathies ,Joubert syndrome and related disorders ,Eye Abnormalities ,Child ,Genetics (clinical) ,Encephalocele ,Joubert syndrome ,Genetics ,Polycystic Kidney Diseases ,0303 health sciences ,ddc:618 ,Cerebellar Diseases/diagnosis/genetics ,Kidney Diseases, Cystic ,Pedigree ,3. Good health ,Phenotype ,Child, Preschool ,Medical genetics ,Female ,Retinitis Pigmentosa ,FORM ,Ciliary Motility Disorders ,Heterozygote ,medicine.medical_specialty ,2716 Genetics (clinical) ,Adolescent ,Molecular Sequence Data ,Encephalocele/diagnosis/genetics ,AHI1 ,610 Medicine & health ,Biology ,Retina ,Article ,Ciliopathies, INPP5E, Joubert syndrome and related disorders, Meckel syndrome ,NO ,Ciliary Motility Disorders/diagnosis/genetics ,03 medical and health sciences ,1311 Genetics ,Cerebellar Diseases ,REVEALS ,medicine ,Humans ,Abnormalities, Multiple ,Amino Acid Sequence ,Kidney Diseases, Cystic/diagnosis/genetics ,abnormalities ,multiple ,adolescent ,amino acid sequence ,cerebellar diseases ,cerebellum ,child ,preschool ,ciliary motility disorders ,encephalocele ,eye abnormalities ,female ,heterozygote ,humans ,infant ,kidney diseases, cystic ,male ,molecular sequence data ,pedigree ,phosphoric monoester hydrolases ,polycystic kidney diseases ,prenatal diagnosis ,prevalence ,retina ,gene frequency ,mutation ,phenotype ,030304 developmental biology ,Eye Abnormalities/diagnosis/genetics ,COACH SYNDROME ,Retina/abnormalities ,Genetic heterogeneity ,Respiration disorders -- Therapy ,Infant ,medicine.disease ,Phosphoric Monoester Hydrolases ,INPP5E mutation ,10036 Medical Clinic ,Mutation ,030217 neurology & neurosurgery - Abstract
Joubert syndrome and related disorders (JSRD) are clinically and genetically heterogeneous ciliopathies sharing a peculiar midbrain–hindbrain malformation known as the ‘molar tooth sign’. To date, 19 causative genes have been identified, all coding for proteins of the primary cilium. There is clinical and genetic overlap with other ciliopathies, in particular with Meckel syndrome (MKS), that is allelic to JSRD at nine distinct loci. We previously identified the INPP5E gene as causative of JSRD in seven families linked to the JBTS1 locus, yet the phenotypic spectrum and prevalence of INPP5E mutations in JSRD and MKS remain largely unknown. To address this issue, we performed INPP5E mutation analysis in 483 probands, including 408 JSRD patients representative of all clinical subgroups and 75 MKS fetuses. We identified 12 different mutations in 17 probands from 11 JSRD families, with an overall 2.7% mutation frequency among JSRD. The most common clinical presentation among mutated families (7/11, 64%) was Joubert syndrome with ocular involvement (either progressive retinopathy and/or colobomas), while the remaining cases had pure JS. Kidney, liver and skeletal involvement were not observed. None of the MKS foetuses carried INPP5E mutations, indicating that the two ciliopathies are not allelic at this locus., peer-reviewed
- Published
- 2013
48. Tuscan mining geopark e valorizzazione del patrimonio geologico
- Author
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Casini, A., Cinelli, R., Costantini, A., and Pagani, G.
- Published
- 2013
49. Three-dimensional time-of-flight MR angiography in the evaluation of intracranial aneurysms treated with Guglielmi detachable coils
- Author
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nicoletta anzalone, Righi, C., Simionato, F., Scomazzoni, F., Pagani, G., Calori, G., Santino, P., Scotti, G., Anzalone, NICOLETTA EMANUELA, Righi, C, Simionato, F, Scomazzoni, F, Pagani, G, Calori, G, Santino, P, and Scotti, G.
- Subjects
Male ,Time Factors ,Interventional ,cardiovascular system ,Angiography, Digital Subtraction ,Contrast Media ,Humans ,Female ,Intracranial Aneurysm ,cardiovascular diseases ,Middle Aged ,Magnetic Resonance Angiography - Abstract
BACKGROUND AND PURPOSE: Intravascular treatment of intracranial aneurysms is a relatively new therapeutic technique and long-term controlled angiographic trials are needed to assess persistence of aneurysm occlusion. Our purpose was to evaluate the effectiveness of 3D time-of-flight (3D-TOF) MR angiography as a noninvasive screening tool in the follow-up of cerebral aneurysms treated with Guglielmi detachable coils (GDCs). METHODS: Forty-nine patients with 50 intracranial aneurysms previously treated with GDCs were studied with both DSA and 3D-TOF MR angiography. In 14 cases, a second follow-up examination was performed, for a total of 64 aneurysms evaluated. In 25 aneurysms, both pre- and postcontrast MR angiographic studies were obtained. RESULTS: In seven of 64 aneurysms, the MR angiographic studies were considered to be unreliable owing to the presence of artifacts that obscured part of the parent artery and did not allow an accurate evaluation of the aneurysm neck. These seven aneurysms, however, all were shown to be completely occluded at digital subtraction angiography (DSA). In the remaining 57 aneurysms, DSA revealed complete occlusion in 39 and the presence of residual patency in 18, whereas MR angiography showed complete occlusion in 38 and residual patency in 19. Enhanced MR angiography proved to be useful in evaluating residual patency in large and giant aneurysms and in better depicting the distal branch arteries. CONCLUSION: Although artifacts related to the presence of coils are evident on a considerable number of imaging studies, our findings indicate that MR angiography is useful in the evaluation of residual patency of cerebral aneurysms treated with GDCs and may eventually prove valuable in the follow-up of those cases in which a good initial correlation with DSA was demonstrated.
- Published
- 2000
50. IART® (Intra-Operative Avidination for Radionuclide Therapy) for accelerated radiotherapy in breast cancer patients. Technical aspects and preliminary results of a phase II study with 90Y-labelled biotin
- Author
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Paganelli, Giovanni, De Cicco, C., Ferrari, M. E., Mcvie, G., Pagani, G., Leonardi, M. C., Cremonesi, M., Ferrari, A., Pacifici, M., Di Dia, A., Botta, F., De Santis, R., Galimberti, V., Luini, A., Orecchia, R., and Veronesi, U.
- Subjects
Cancer Research ,Oncology ,NO ,Research Article - Abstract
Background: Breast conserving surgery (BCS) plus external beam radiotherapy (EBRT) is considered the standard treatment for early breast cancer. We have investigated the possibility of irradiating the residual gland, using an innovative nuclear medicine approach named IART® (Intra-operative Avidination for Radionuclide Therapy). Aim: The objective of this study was to determine the optimal dose of avidin with a fixed activity (3.7 GBq) of 90Y-biotin, in order to provide a boost of 20 Gy, followed by EBRT to the whole breast (WB) at the reduced dose of 40 Gy. Local and systemic toxicity, patient’s quality of life, including the cosmetic results after the combined treatment with IART® and EBRT, were assessed. Methods: After tumour excision, the surgeon injected native avidin diluted in 30 ml of saline solution into and around the tumour bed (see video). Patients received one of three avidin dose levels: 50 mg (10 pts), 100 mg (15 pts) and 150 mg (10 pts). Between 12 to 24 h after surgery, 3.7 GBq 90Y-biotin spiked with 185 MBq 111In-biotin was administered intravenously (i.v.). Whole body scans and SPECT images were performed up to 30 h post-injection for dosimetric purposes. WB-EBRT was administered four weeks after the IART® boost. Local toxicity and quality of life were evaluated. Results: Thirty-five patients were evaluated. No side effects were observed after avidin administration and 90Y-biotin infusion. An avidin dose level of 100 mg resulted the most appropriate in order to deliver the required radiation dose (19.5 ± 4.0 Gy) to the surgical bed. At the end of IART®, no local toxicity occurred and the overall cosmetic result was good. The tolerance to the reduced EBRT was also good. The highest grade of transient local toxicity was G3, which occurred in 3/32 pts following the completion of WB-EBRT. The combination of IART®+EBRT was well accepted by the patients, without any changes to their quality of life. Conclusions: These preliminary results support the hypothesis that IART® may represent a valid approach to accelerated WB irradiation after BCS. We hope that this nuclear medicine technique will contribute to a better management of breast cancer patients.
- Published
- 2010
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