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19 results on '"PIGNOT, Marc"'

11. Economic Burden of Organ Damage in Systemic Lupus Erythematosus: Results From a German Claims Analysis

Author

Schultze, Michael, Garal-Pantaler, Elena, Pignot, Marc, Carnarius, Heike, Gairy, Kerry, and Levy, Roger

Subjects
ddc: 610, immune system diseases, 610 Medical sciences, Medicine, skin and connective tissue diseases
Abstract

Introduction: Irreversible organ damage (OD) occurs in 33-54% of patients with systemic lupus erythematosus (SLE) within 5 years of diagnosis [ref:1], [ref:2], [ref:3]. There are limited real-world studies on the economic burden of SLE long-term OD. This study assessed[for full text, please go to the a.m. URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021

13. COPD Exacerbation History and Impact on Future Exacerbations – 8-Year Retrospective Observational Database Cohort Study from Germany

Author

Vogelmeier,Claus F, Diesing,Joanna, Kossack,Nils, Pignot,Marc, Friedrich,Felix W, Vogelmeier,Claus F, Diesing,Joanna, Kossack,Nils, Pignot,Marc, and Friedrich,Felix W

Abstract

Claus F Vogelmeier,1 Joanna Diesing,2 Nils Kossack,2 Marc Pignot,3 Felix W Friedrich4 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, Marburg, Hessen, Germany; 2WIG2 GmbH Scientific Institute for Health Economics and Health System Research, Leipzig, Sachsen, Germany; 3Kantar Health, Munich, Germany; 4AstraZeneca, Wedel, GermanyCorrespondence: Felix W FriedrichAstraZeneca GmbH, Tinsdaler Weg 183, Wedel, D-22880, GermanyTel +49 162 1398835Email felix.friedrich@astrazeneca.comBackground: Recent studies evaluating the predictive value of different variables on future exacerbations suggest exacerbation history as the strongest predictor. We examined the effect of exacerbation history on subsequent events in a large sample population with over 250,000 COPD patients using up to 8 years of longitudinal healthcare data from Germany.Methods: Patients 40 years or older with any COPD diagnosis in primary or secondary care were included from 2011 to 2017 (index period) from healthcare insurance claims (Germany; WIG2 research database), with 12 months before index date as baseline and at least 12-month follow-up. Exacerbations during baseline were defined as moderate (treatment with oral corticosteroids or antibiotics, J01AA, J01CA) or severe (emergency visit or hospitalization).Results: Patients without (category A), with one moderate (category B), or with either one severe or several baseline exacerbations (category C) experienced an average of 0.9 (CI 0.9– 0.9), 1.9 (CI 1.9– 1.9), and 6.3 (CI 6.1– 6.3) exacerbations during the first 3 years of follow-up, respectively. By 8 years, 87.0% (CI 86.6– 87.4), 70.5% (CI 69.9– 71.0) and 49.1% (CI 48.9– 49.3) of category C, B and A patients had experienced a subsequent exacerbation.Conclusion: Baseline exacerbations increased the likelihood of, and reduced time to subsequent exacerbations. Even patients without baseline exacerbations

Published
2021

16. Epidemiology of Prurigo Nodularis compared with Psoriasis in Germany: A Claims Database Analysis.

Author

STÄNDER, Sonja, KETZ, Miriam, KOSSACK, Nils, AKUMO, Divine, PIGNOT, Marc, GABRIEL, Sylvie, and CHAVDA, Rajeev

Subjects
PSORIASIS, EPIDEMIOLOGY, SKIN diseases, COMORBIDITY, MENTAL depression
Abstract

Prurigo nodularis is an itchy skin disease with unknown epidemiology. This study aimed to describe the epidemiology of prurigo nodularis compared with that of psoriasis. The German sickness fund claims database, with 2,783,175 continuously insured patients, included 1,720 patients diagnosed with prurigo nodularis and 51,390 with psoriasis. Patients with prurigo nodularis were averagely 8 years older than psoriasis patients and more often were women (p < 0.001). Annual incidence was a constant 0.02% in prurigo nodularis, and decreased steadily from 0.53 to 0.42% in psoriasis; cumulative incidence was 0.1% for prurigo nodularis and 1.9% for psoriasis. Prevalence was 0.1% for prurigo nodularis and 4.7% for psoriasis, with a one-year mortality of 5.4% for prurigo nodularis and 1.2% for psoriasis (p < 0.001). The most frequent preexisting comorbidities in patients with prurigo nodularis were inflammatory dermatoses and depression. This epidemiological study found a low prevalence of prurigo nodularis, manifesting different demographics and comorbidities compared with psoriasis. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Recurrent hyperkalaemia management and use of renin–angiotensin–aldosterone system inhibitors: a European multi-national targeted chart review.

Author

Rossignol, Patrick, Ruilope, Luis M, Cupisti, Adamasco, Ketteler, Markus, Wheeler, David C, Pignot, Marc, Cornea, Georgiana, Schulmann, Thierry, and Lund, Lars H

Subjects
RENIN-angiotensin system, ALDOSTERONE antagonists
Abstract

Recurrent hyperkalaemia management and use of renin-angiotensin-aldosterone system inhibitors: a European multi-national targeted chart review. [Extracted from the article]

Published
2020
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19. Structure of the N6-adenine DNA methyltransferase M•TaqI in complex with DNA and a cofactor analog

Author

Goedecke, Karsten, Pignot, Marc, Goody, Roger S., Scheidig, Axel J., and Weinhold, Elmar

Abstract

The 2.0 Å crystal structure of the N6-adenine DNA methyltransferase M•TaqI in complex with specific DNA and a nonreactive cofactor analog reveals a previously unrecognized stabilization of the extrahelical target base. To catalyze the transfer of the methyl group from the cofactor S-adenosyl-l-methionine to the 6-amino group of adenine within the double-stranded DNA sequence 5′-TCGA-3′, the target nucleoside is rotated out of the DNA helix. Stabilization of the extrahelical conformation is achieved by DNA compression perpendicular to the DNA helix axis at the target base pair position and relocation of the partner base thymine in an interstrand π-stacked position, where it would sterically overlap with an innerhelical target adenine. The extrahelical target adenine is specifically recognized in the active site, and the 6-amino group of adenine donates two hydrogen bonds to Asn 105 and Pro 106, which both belong to the conserved catalytic motif IV of N6-adenine DNA methyltransferases. These hydrogen bonds appear to increase the partial negative charge of the N6 atom of adenine and activate it for direct nucleophilic attack on the methyl group of the cofactor.

Published
2001
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