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1. A pilot study of oral iron therapy in erythropoietic protoporphyria and X-linked protoporphyria

Author: Balwani, Manisha, Naik, Hetanshi, Overbey, Jessica R, Bonkovsky, Herbert L, Bissell, D Montgomery, Wang, Bruce, Phillips, John D, Desnick, Robert J, and Anderson, Karl E
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Liver Disease, Digestive Diseases, Rare Diseases, Hematology, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Erythropoietic protoporphyria, X -linked protoporphyria, Photosensitivity, Clinical trial, Iron, ALAS2, 5-aminolevulinate synthase 2, DSMB, Data and Safety Monitoring Board, EPP, erythropoietic protoporphyria, FECH, ferrochelatase, IRE, iron-responsive element, IRP, IRE binding proteins, QoL, Quality of Life, X-linked protoporphyria, XLP, X linked protoporphyria, ePPIX, erythrocyte protoporphyrin, Biochemistry and Cell Biology, Genetics, Clinical sciences
Abstract: The use of iron supplementation for anemia in erythropoietic protoporphyria (EPP) is controversial with both benefit and deterioration reported in single case reports. There is no systematic study to evaluate the benefits or risks of iron supplementation in these patients. We assessed the potential efficacy of oral iron therapy in decreasing erythrocyte protoporphyrin (ePPIX) levels in patients with EPP or X-linked protoporphyria (XLP) and low ferritin in an open-label, single-arm, interventional study. Sixteen patients (≥18 years) with EPP or XLP confirmed by biochemical and/or genetic testing, and serum ferritin ≤30 ng/mL were enrolled. Baseline testing included iron studies, normal hepatic function, and elevated plasma porphyrins and ePPIX levels. Oral ferrous sulfate 325 mg twice daily was administered for 12 months. The primary efficacy outcome was the relative difference in total ePPIX level between baseline and 12 months after starting treatment with iron. Secondary measures included improvement in serum ferritin, plasma porphyrins, and clinical symptoms. Thirteen patients had EPP (8 females, 5 males) and 3 had XLP (all females) and the mean age of participants was 38.8 years (SD 14.5). Ten patients completed all study visits limiting interpretation of results. In EPP patients, a transient increase in ePPIX levels was observed at 3 months in 9 of 12 (75%) patients. Iron was discontinued in 2 of these patients after meeting the protocol stopping rule of a 35% increase in ePPIX. Seven patients withdrew before study end. Ferritin levels increased on iron replacement indicating an improvement in iron status. A decrease in ePPIX was seen in both XLP patients who completed the study (relative difference of 0.67 and 0.5 respectively). No substantial changes in ePPIX were seen in EPP patients at the end of the study (n = 8; median relative difference: -0.21 (IQR: -0.44, 0.05). The most common side effects of iron treatment were gastrointestinal symptoms. Hepatic function remained normal throughout the study. Our study showed that oral iron therapy repletes iron stores and transiently increases ePPIX in some EPP patients, perhaps due to a transient increase in erythropoiesis, and may decrease ePPIX in XLP patients. Further studies are needed to better define the role of iron repletion in EPP. Trial registration: NCT02979249.
Published: 2022

2. Association of tricuspid regurgitation with clinical events and quality of life after surgery for severe ischemic mitral regurgitation

Author: Strobel, Raymond J., Kramer, Benjamin P., Overbey, Jessica R., Mehaffey, J. Hunter, Hawkins, Robert B., II, Gammie, James S., Gillinov, Marc, Acker, Michael A., Kramer, Robert S., Smith, Peter K., Kron, Irving L., Voisine, Pierre, Taddei-Peters, Wendy C., Geller, Nancy L., Dagenais, François, Mack, Michael J., Moquete, Ellen G., Marks, Mary E., Iribarne, Alexander, Goldstein, Daniel J., Ailawadi, Gorav, O'Gara, Patrick T., Moskowitz, Alan J., Gelijns, Annetine C., and Bagiella, Emilia
Published: 2024
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3. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Author: Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R
Published: 2024
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4. Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria.

Author: Naik, Hetanshi, Overbey, Jessica R, Montgomery, Guy H, Winkel, Gary, Balwani, Manisha, Anderson, Karl E, Bissell, D Montgomery, Bonkovsky, Herbert L, Phillips, John D, Wang, Bruce, McGuire, Brendan, Keel, Siobán, Levy, Cynthia, Erwin, Angelika, and Desnick, Robert J
Subjects: Humans, Porphyria, Acute Intermittent, Fatigue, Heme, Severity of Illness Index, Longitudinal Studies, Depression, Anxiety, Quality of Life, Adolescent, Adult, Aged, Middle Aged, Female, Male, Young Adult, Sleep Wake Disorders, Patient Reported Outcome Measures, PROMIS, acute intermittent porphyria, patient-reported outcomes, quality of life, Genetics, Clinical Sciences, Genetics & Heredity
Abstract: PurposeAcute intermittent porphyria (AIP) is a rare inborn error of heme biosynthesis characterized by life-threatening acute attacks. Few studies have assessed quality of life (QoL) in AIP and those that have had small sample sizes and used tools that may not have captured important domains.MethodsBaseline data from the Porphyrias Consortium's Longitudinal Study were obtained for 259 patients, including detailed disease and medical history data, and the following Patient-Reported Outcomes Measurement Information System (PROMIS) scales: anxiety, depression, pain interference, fatigue, sleep disturbance, physical function, and satisfaction with social roles. Relationships between PROMIS scores and clinical and biochemical AIP features were explored.ResultsPROMIS scores were significantly worse than the general population across all domains, except depression. Each domain discriminated well between asymptomatic and symptomatic patients with symptomatic patients having worse scores. Many important clinical variables like symptom frequency were significantly associated with domain scores in univariate analyses, showing responsiveness of the scales, specifically pain interference and fatigue. However, most regression models only explained ~20% of the variability observed in domain scores.ConclusionPain interference and fatigue were the most responsive scales in measuring QoL in this AIP cohort. Future studies should assess whether these scales capture longitudinal disease progression and treatment response.
Published: 2020

5. A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults

Author: Costi, Sara, Evers, Audrey, Jha, Manish K., Klein, Matthew, Overbey, Jessica R., Goosens, Ki A., Burgess, JoColl, Alvarez, Kelvin, Feder, Adriana, Charney, Dennis S., and Murrough, James W.
Published: 2023
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6. Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X‐linked protoporphyria

Author: Naik, Hetanshi, Overbey, Jessica R, Desnick, Robert J, Anderson, Karl E, Bissell, D Montgomery, Bloomer, Joseph, Bonkovsky, Herbert L, Phillips, John D, Wang, Bruce, Singal, Ashwani, and Balwani, Manisha
Subjects: Health Services and Systems, Health Sciences, Clinical Research, Brain Disorders, Pain Research, PROMIS, erythropoietic proto, porphyria, quality of life, Clinical sciences
Abstract: BackgroundErythropoietic protoporphyria (EPP) and X-linked Protoporphyria (XLP) are rare photodermatoses presenting with severe phototoxicity. Although anecdotally, providers who treat EPP patients acknowledge their life-altering effects, tools that fully capture their impact on quality of life (QoL) are lacking.MethodsAdult patients with EPP/XLP were given four validated QoL tools: the Patient Reported Outcomes Measurement Information System 57 (PROMIS-57), the Hospital Anxiety and Depression Scale (HADS), the Illness Perception Questionnaire Revised (IPQR), and an EPP-Specific tool. All patients received the PROMIS-57 while the HADS, IPQR, and EPP-Specific tools were introduced at a later date. Associations between responses and clinical phenotypes were explored.ResultsTwo hundred and two patients were included; 193 completed PROMIS-57, 104 completed IPQR, 103 completed HADS, and 107 completed the EPP-Specific tool. The IPQR showed that patients strongly believed EPP/XLP had a negative impact on their lives. Mean scores in anxiety and depression domains of both HADS and PROMIS-57 were normal; however, anxiety scores from HADS were borderline/abnormal in 20% of patients. The EPP-Specific tool revealed a decreased QoL in most patients. The PROMIS-57 showed that 21.8% of patients have clinically significant pain interference. Several tool domains correlated with measures of disease severity, most being from the PROMIS-57.ConclusionsImpaired QoL is an important consequence of EPP/XLP. PROMIS-57 was most sensitive in evaluating impaired QoL in EPP/XLP. Further research is needed to compare the effectiveness of it for assessing response to treatment.
Published: 2019

7. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author: Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Hung, Judy, Zeng, Xin, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Ferket, Bart S., Hohmann, Samuel F., Chang, Helena L., Mick, Stephanie L., Hung, Judy W., Overbey, Jessica R., and Lala, Anuradha
Published: 2020
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8. Risk for non-home discharge following surgery for ischemic mitral valve disease

Author: DeRose, Joseph J., Wang, Alice, Smith, Peter K., Acker, Michael A., Ailawadi, Gorav, Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard D., Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Foo, James, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Williams, Deborah, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Lawrence, Rita, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Geither, Carrie, Doud, Kristen, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Mangusan, Ralph, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Jonathan Lacharité, Sophie Robichaud, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Villanueva, Robert, Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Kilcullen, Niamh, Hung, David, Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Lala, Anuradha, Chang, Helena L., Liu, Xiaoyu, Charles, Eric J., Yerokun, Babatunde A., Bowdish, Michael E., Mack, Michael J., and Stevenson, Lynne W.
Published: 2021
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9. Functional impairments for outcomes in a randomized trial of unruptured brain AVMs

Author: Mohr, JP, Overbey, Jessica R, von Kummer, Ruediger, Stefani, Marco A, Libman, Richard, Stapf, Christian, Parides, Michael K, Pile-Spellman, John, Moquete, Ellen, Moy, Claudia S, Vicaut, Eric, Moskowitz, Alan J, Harkness, Kirsty, Cordonnier, Charlotte, Biondi, Alessandra, Houdart, Emmanuel, Berkefeld, Joachim, Klijn, Catharina JM, Barreau, Xavier, Kim, Helen, and Hartmann, Andreas
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Rehabilitation, Clinical Trials and Supportive Activities, Brain Disorders, Clinical Research, Stroke, Neurosciences, Adolescent, Adult, Embolization, Therapeutic, Female, Follow-Up Studies, Humans, Intracranial Arteriovenous Malformations, Kaplan-Meier Estimate, Male, Middle Aged, Postoperative Complications, Retrospective Studies, Treatment Outcome, Young Adult, International ARUBA Investigators, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract: ObjectiveTo investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA).MethodsWe used the initial results of a nonblinded, randomized, controlled, parallel-group trial involving adults ≥18 years of age with an unruptured brain arteriovenous malformation (AVM) to compare the effects of medical management (MM) with or without interventional therapy (IT) on functional impairment, defined by a primary outcome of death or symptomatic stroke causing modified Rankin Scale (mRS) score ≥2. ARUBA closed recruitment on April 15, 2013.ResultsAfter a median of 33.3 months of follow-up (interquartile range 16.3-49.8 months), of the 223 enrolled in the trial, those in the MM arm were less likely to experience primary outcomes with an mRS score ≥2 than those who underwent IT. The results applied for both those as randomized (MM n = 109 vs IT n = 114) (hazard ratio [HR] 0.25, 95% confidence interval [CI] 0.11-0.57, p = 0.001) and as treated (MM n = 125 vs IT n = 98) (HR 0.10, 95% CI 0.04-0.28, p < 0.001). Functional impairment for the outcomes showed no significant difference by Spetzler-Martin grade for MM but was more frequent with increasing grades for IT (p < 0.001).ConclusionDeath or stroke with functional impairment in ARUBA after a median follow-up of 33 months was significantly lower for those in the MM arm both as randomized and as treated compared with those with IT. Functional severity of outcomes was lower in the MM arm, regardless of Spetzler-Martin grades.Clinicaltrialsgov identifierNCT00389181.Classification of evidenceThis study provides Class II evidence that for adults with unruptured brain AVMs, interventional management compared to MM increases the risk of disability and death over ≈3 years.
Published: 2017

10. Impact of Aortic Atherosclerosis Burden on Outcomes of Surgical Aortic Valve Replacement

Author: Iribarne, Alexander, Pan, Stephanie, McCullough, Jock N., Mathew, Joseph P., Hung, Judy, Zeng, Xin, Voisine, Pierre, O’Gara, Patrick T., Sledz, Nancy M., Gelijns, Annetine C., Taddei-Peters, Wendy C., Messé, Steven R., Moskowitz, Alan J., Thourani, Vinod H., Argenziano, Michael, Groh, Mark A., Giustino, Gennaro, Overbey, Jessica R., DiMaio, J. Michael, and Smith, Peter K.
Published: 2020
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11. The D519G Polymorphism of Glyceronephosphate O-Acyltransferase Is a Risk Factor for Familial Porphyria Cutanea Tarda

Author: Farrell, Colin P, Overbey, Jessica R, Naik, Hetanshi, Nance, Danielle, McLaren, Gordon D, McLaren, Christine E, Zhou, Luming, Desnick, Robert J, Parker, Charles J, and Phillips, John D
Subjects: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Digestive Diseases, Clinical Research, Hematology, Liver Disease, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, General Science & Technology
Abstract: Both familial and sporadic porphyria cutanea tarda (PCT) are iron dependent diseases. Symptoms of PCT resolve when iron stores are depleted by phlebotomy, and a sequence variant of HFE (C282Y, c.843G>A, rs1800562) that enhances iron aborption by reducing hepcidin expression is a risk factor for PCT. Recently, a polymorphic variant (D519G, c.1556A>G, rs11558492) of glyceronephosphate O-acyltransferase (GNPAT) was shown to be enriched in male patients with type I hereditary hemochromatosis (HFE C282Y homozygotes) who presented with a high iron phenotype, suggesting that GNPAT D519G, like HFE C282Y, is a modifier of iron homeostasis that favors iron absorption. To challenge this hypothesis, we investigated the frequency of GNPAT D519G in patients with both familial and sporadic PCT. Patients were screened for GNPAT D519G and allelic variants of HFE (both C282Y and H63D). Nucleotide sequencing of uroporphyrinogen decarboxylase (URO-D) identified mutant alleles. Patients with low erythrocyte URO-D activity or a damaging URO-D variant were classified as familial PCT (fPCT) and those with wild-type URO-D were classified as sporadic PCT (sPCT). GNPAT D519G was significantly enriched in the fPCT patient population (p = 0.0014) but not in the sPCT population (p = 0.4477). Both HFE C282Y and H63D (c.187C>G, rs1799945) were enriched in both PCT patient populations (p
Published: 2016

12. Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network

Author: Giustino, Gennaro, Overbey, Jessica, Taylor, Doris, Ailawadi, Gorav, Kirkwood, Katherine, DeRose, Joseph, Gillinov, Marc A., Dagenais, François, Mayer, Mary-Lou, Moskowitz, Alan, Bagiella, Emilia, Miller, Marissa, Grayburn, Paul, Smith, Peter K., Gelijns, Annetine, O'Gara, Patrick, Acker, Michael, Lala, Anuradha, and Hung, Judy
Published: 2019
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13. Endometrial preparation before the transfer of single, vitrified-warmed, euploid blastocysts: does the duration of estradiol treatment influence clinical outcome?

Author: Sekhon, Lucky, Feuerstein, Jessica, Pan, Stephanie, Overbey, Jessica, Lee, Joseph A., Briton-Jones, Christine, Flisser, Eric, Stein, Daniel E., Mukherjee, Tanmoy, Grunfeld, Lawrence, Sandler, Benjamin, and Copperman, Alan B.
Published: 2019
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14. Biatrial maze procedure versus pulmonary vein isolation for atrial fibrillation during mitral valve surgery: New analytical approaches and end points

Author: Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Connolly, Amy, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Kumbarce, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Blackwell, Ray, Kerzner, Roger, Banbury, Michael, Squire, Andrea M., Gillinov, A. Marc, Blackstone, Eugene H., Lytle, Bruce, Mihaljevic, Tomislav, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevack, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismael, Denault, André, Lacharité, Jonathan, Robichaud, Sophie, Adams, David H., Varghese, Robin, Mandel-Portnoy, Yael, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., DeFilippi, Christopher R., Gaetani, Dino T., Young, Cindi A., Beach, Dana, Collins, Julia, Bolling, Steven F., Pagani, Francis D., Bloem, Cathie, Acker, Michael A., Woo, Y. Joseph, Mayer, Mary Lou, Bavaria, Joseph E., Szeto, Wilson Y., Margulies, Kenneth, Keane, Martin, Glassberg, Helene, Jagasia, Dinesh, Kirkpatrick, James, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Mangi, Abeel, Akar, Joseph, Yuh, David, Wilson, Lynn, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Canty, John M., Jr., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Couderc, Jean-Philippe, Balda, Dan, Bowen, Wayne, Wilson, Mauri, Schering, Anne, Chang, Helena L., Rajeswaran, Jeevanantham, Ishwaran, Hemant, Li, Liang, Ehrlinger, John, Couderc, Jean-Phillipe, and Mack, Michael J.
Published: 2019
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15. Hysterectomy at the time of risk-reducing surgery in BRCA carriers

Author: Nair, Navya, Schwartz, Melissa, Guzzardi, Lisa, Durlester, Nicki, Pan, Stephanie, Overbey, Jessica, and Chuang, Linus
Published: 2018
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16. Early manifestations of type 1 Gaucher disease in presymptomatic children diagnosed after parental carrier screening

Author: Yang, Amy C., Bier, Louise, Overbey, Jessica R., Cohen-Pfeffer, Jessica, Desai, Khyati, Desnick, Robert J., and Balwani, Manisha
Published: 2017
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17. Infarct‐related structural disconnection and delirium in surgical aortic valve replacement patients.

Author: Browndyke, Jeffrey N., Tomalin, Lewis E., Erus, Guray, Overbey, Jessica R., Kuceyeski, Amy, Moskowitz, Alan J., Bagiella, Emilia, Iribarne, Alexander, Acker, Michael, Mack, Michael, Mathew, Joseph, O'Gara, Patrick, Gelijns, Annetine C., Suarez‐Farinas, Mayte, Messé, Steven R., Fenton, Kathleen, Miller, Marissa A., Taddei‐Peters, Wendy C., Jeffries, Neal O., and Buxton, Dennis
Abstract: Objective: Although acute brain infarcts are common after surgical aortic valve replacement (SAVR), they are often unassociated with clinical stroke symptoms. The relationship between clinically "silent" infarcts and in‐hospital delirium remains uncertain; obscured, in part, by how infarcts have been traditionally summarized as global metrics, independent of location or structural consequence. We sought to determine if infarct location and related structural connectivity changes were associated with postoperative delirium after SAVR. Methods: A secondary analysis of a randomized multicenter SAVR trial of embolic protection devices (NCT02389894) was conducted, excluding participants with clinical stroke or incomplete neuroimaging (N = 298; 39% female, 7% non‐White, 74 ± 7 years). Delirium during in‐hospital recovery was serially screened using the Confusion Assessment Method. Parcellation and tractography atlas‐based neuroimaging methods were used to determine infarct locations and cortical connectivity effects. Mixed‐effect, zero‐inflated gaussian modeling analyses, accounting for brain region‐specific infarct characteristics, were conducted to examine for differences within and between groups by delirium status and perioperative neuroprotection device strategy. Results: 23.5% participants experienced postoperative delirium. Delirium was associated with significantly increased lesion volumes in the right cerebellum and temporal lobe white matter, while diffusion weighted imaging infarct‐related structural disconnection (DWI‐ISD) was observed in frontal and temporal lobe regions (p‐FDR < 0.05). Fewer brain regions demonstrated DWI‐ISD loss in the suction‐based neuroprotection device group, relative to filtration‐based device or standard aortic cannula. Interpretation: Structural disconnection from acute infarcts was greater in patients who experienced postoperative delirium, suggesting that the impact from covert perioperative infarcts may not be as clinically "silent" as commonly assumed. [ABSTRACT FROM AUTHOR]
Published: 2024
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18. Predicting recurrent mitral regurgitation after mitral valve repair for severe ischemic mitral regurgitation

Author: Kron, Irving L., Hung, Judy, Overbey, Jessica R., Bouchard, Denis, Gelijns, Annetine C., Moskowitz, Alan J., Voisine, Pierre, O'Gara, Patrick T., Argenziano, Michael, Michler, Robert E., Gillinov, Marc, Puskas, John D., Gammie, James S., Mack, Michael J., Smith, Peter K., Sai-Sudhakar, Chittoor, Gardner, Timothy J., Ailawadi, Gorav, Zeng, Xin, O'Sullivan, Karen, Parides, Michael K., Swayze, Roger, Thourani, Vinod, Rose, Eric A., Perrault, Louis P., and Acker, Michael A.
Published: 2015
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19. IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens

Author: Maglione, Paul J., Simchoni, Noa, Black, Samuel, Radigan, Lin, Overbey, Jessica R., Bagiella, Emilia, Bussel, James B., Bossuyt, Xavier, Casanova, Jean-Laurent, Meyts, Isabelle, Cerutti, Andrea, Picard, Capucine, and Cunningham-Rundles, Charlotte
Published: 2014
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20. A pilot study of oral iron therapy in erythropoietic protoporphyria and X-linked protoporphyria

Author: Balwani, Manisha, primary, Naik, Hetanshi, additional, Overbey, Jessica R., additional, Bonkovsky, Herbert L., additional, Bissell, D. Montgomery, additional, Wang, Bruce, additional, Phillips, John D., additional, Desnick, Robert J., additional, and Anderson, Karl E., additional
Published: 2022
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21. Pacemaker implantation associated with tricuspid repair in the setting of mitral valve surgery: Insights from a Cardiothoracic Surgical Trials Network randomized trial

Author: Ailawadi, Gorav, primary, Voisine, Pierre, additional, Raymond, Samantha, additional, Gelijns, Annetine C., additional, Moskowitz, Alan J., additional, Falk, Volkmar, additional, Overbey, Jessica R., additional, Chu, Michael W.A., additional, Mack, Michael J., additional, Bowdish, Michael E., additional, Krane, Markus, additional, Yerokun, Babatunde, additional, Conradi, Lenard, additional, Bolling, Steven F., additional, Miller, Marissa A., additional, Taddei-Peters, Wendy C., additional, Fenton, Kathleen N., additional, Jeffries, Neal O., additional, Kramer, Robert S., additional, Geirsson, Arnar, additional, Moquete, Ellen G., additional, O'Sullivan, Karen, additional, Hupf, Jonathan, additional, Hung, Judy, additional, Beyersdorf, Friedhelm, additional, Bagiella, Emilia, additional, Gammie, James S., additional, O'Gara, Patrick T., additional, Iribarne, Alexander, additional, Borger, Michael A., additional, and Gillinov, Marc, additional
Published: 2022
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22. Prevalence of elevated alanine aminotransferase (ALT) in pregnancy: A cross-sectional labor and delivery-based assessment

Author: Kushner, Tatyana, primary, Park, Claire, additional, Masand, Dana, additional, Rosenbluth, Emma, additional, Carroll, Carin, additional, Grace, Marie, additional, Rodriguez-Rivas, Clara, additional, De La Cruz, Hernis, additional, Overbey, Jessica, additional, and Sperling, Rhoda, additional
Published: 2022
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23. Abstract 19592: Posterior Leaflet Tethering Correlates With LV Size to MV Ring Mismatch for MV Repair in Ischemic Mitral Regurgitation: Mechanistic and Clinical Insights for Recurrence of Ischemic Mitral Regurgitation Post Restrictive Ring Annuloplasty

Author: Capoulade, Romain, Overbey, Jessica, Mihos, Christos G, Acker, Michael, Ailawadi, Gorav, Alexander, John, Bowdish, Michael, Gammie, James, Gelijns, Annetine, Grayburn, Paul, Melnitchouk, Serguei, Michler, Robert, OʼGara, Patrick, Smith, Peter, Taub, Cynthia, and Hung, Judy
Published: 2017

24. Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

Author: Gammie, James S, Chu, Michael W A, Falk, Volkmar, Overbey, Jessica R; https://orcid.org/0000-0001-7283-1661, Moskowitz, Alan J, Gillinov, Marc, Mack, Michael J, Voisine, Pierre, Krane, Markus, Yerokun, Babatunde; https://orcid.org/0000-0003-2663-8283, Bowdish, Michael E, Conradi, Lenard, Bolling, Steven F, Miller, Marissa A, Taddei-Peters, Wendy C, Jeffries, Neal O, Parides, Michael K, Weisel, Richard, Jessup, Mariell, Rose, Eric A, Mullen, John C, Raymond, Samantha, Moquete, Ellen G, O’Sullivan, Karen, Marks, Mary E, Iribarne, Alexander, Beyersdorf, Friedhelm; https://orcid.org/0000-0003-2975-2751, Borger, Michael A, Geirsson, Arnar, Bagiella, Emilia, Schuepbach, Reto, et al, Gammie, James S, Chu, Michael W A, Falk, Volkmar, Overbey, Jessica R; https://orcid.org/0000-0001-7283-1661, Moskowitz, Alan J, Gillinov, Marc, Mack, Michael J, Voisine, Pierre, Krane, Markus, Yerokun, Babatunde; https://orcid.org/0000-0003-2663-8283, Bowdish, Michael E, Conradi, Lenard, Bolling, Steven F, Miller, Marissa A, Taddei-Peters, Wendy C, Jeffries, Neal O, Parides, Michael K, Weisel, Richard, Jessup, Mariell, Rose, Eric A, Mullen, John C, Raymond, Samantha, Moquete, Ellen G, O’Sullivan, Karen, Marks, Mary E, Iribarne, Alexander, Beyersdorf, Friedhelm; https://orcid.org/0000-0003-2975-2751, Borger, Michael A, Geirsson, Arnar, Bagiella, Emilia, Schuepbach, Reto, and et al
Abstract: Background: Tricuspid regurgitation is common in patients with severe degenerative mitral regurgitation. However, the evidence base is insufficient to inform a decision about whether to perform tricuspid-valve repair during mitral-valve surgery in patients who have moderate tricuspid regurgitation or less-than-moderate regurgitation with annular dilatation. Methods: We randomly assigned 401 patients who were undergoing mitral-valve surgery for degenerative mitral regurgitation to receive a procedure with or without tricuspid annuloplasty (TA). The primary 2-year end point was a composite of reoperation for tricuspid regurgitation, progression of tricuspid regurgitation by two grades from baseline or the presence of severe tricuspid regurgitation, or death. Results: Patients who underwent mitral-valve surgery plus TA had fewer primary-end-point events than those who underwent mitral-valve surgery alone (3.9% vs. 10.2%) (relative risk, 0.37; 95% confidence interval [CI], 0.16 to 0.86; P = 0.02). Two-year mortality was 3.2% in the surgery-plus-TA group and 4.5% in the surgery-alone group (relative risk, 0.69; 95% CI, 0.25 to 1.88). The 2-year prevalence of progression of tricuspid regurgitation was lower in the surgery-plus-TA group than in the surgery-alone group (0.6% vs. 6.1%; relative risk, 0.09; 95% CI, 0.01 to 0.69). The frequencies of major adverse cardiac and cerebrovascular events, functional status, and quality of life were similar in the two groups at 2 years, although the incidence of permanent pacemaker implantation was higher in the surgery-plus-TA group than in the surgery-alone group (14.1% vs. 2.5%; rate ratio, 5.75; 95% CI, 2.27 to 14.60). Conclusions: Among patients undergoing mitral-valve surgery, those who also received TA had a lower incidence of a primary-end-point event than those who underwent mitral-valve surgery alone at 2 years, a reduction that was driven by less frequent progression to severe tricuspid regurgitation. Tricuspid repair resul
Published: 2022

25. The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement

Author: Messé, Steven R., primary, Overbey, Jessica R., additional, Thourani, Vinod H., additional, Moskowitz, Alan J., additional, Gelijns, Annetine C., additional, Groh, Mark A., additional, Mack, Michael J., additional, Ailawadi, Gorav, additional, Furie, Karen L., additional, Southerland, Andrew M., additional, James, Michael L., additional, Moy, Claudia Scala, additional, Gupta, Lopa, additional, Voisine, Pierre, additional, Perrault, Louis P., additional, Bowdish, Michael E., additional, Gillinov, A. Marc, additional, O'Gara, Patrick T., additional, Ouzounian, Maral, additional, Whitson, Bryan A., additional, Mullen, John C., additional, Miller, Marissa A., additional, Gammie, James S., additional, Pan, Stephanie, additional, Erus, Guray, additional, Browndyke, Jeffrey N., additional, Taddei-Peters, Wendy C., additional, Jeffries, Neal O., additional, Buxton, Dennis, additional, Geller, Nancy L., additional, Gordon, David, additional, Burke, Catherine, additional, Lee, Albert, additional, Smith, Tyrone, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Moquete, Ellen, additional, Shah, Kinjal, additional, Chang, Helena, additional, Chase, Melissa, additional, Goldfarb, Seth, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, O'Sullivan, Karen, additional, Santos, Milerva, additional, Ye, Xia, additional, Mack, Michael, additional, Winkle, Rachelle, additional, Boswell, Haley, additional, Fenlon, Amanda, additional, Johnson, Melissa, additional, Jones, Jessica, additional, Kolb, Megan, additional, Lam, Sarah, additional, Miranda, Lucy, additional, Ward, Jackie, additional, Whitman, Renessa, additional, Zingler, Brittany, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Nosnik, Pedro, additional, Blackstone, Eugene H., additional, Moazami, Nader, additional, Starling, Randall C., additional, Barzilai, Benico, additional, Grimm, Richard A., additional, Soltesz, Edward G., additional, Katzan, Irene, additional, Strippy, Brian, additional, Smith, Shoi, additional, Garcia, Michelle, additional, Alice bowman, Mary, additional, Geither, Carrie, additional, Wang, Robert, additional, Argenziano, Michael, additional, Borger, Michael, additional, Takayama, Hiroo, additional, Leon, Martin B., additional, Goldsmith, Lyn, additional, Schwartz, Allan, additional, Sookraj, Nadia, additional, McCright-Gill, Talaya, additional, Sreekanth, Sowmya, additional, McCullough, Jock N., additional, Iribarne, Alexander, additional, DeSimone, Joseph P., additional, DiScipio, Anthony W., additional, Stokes, Henry, additional, Ivany, Amanda St., additional, Petty, Gaylin, additional, Smith, Peter K., additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Huber, Joel, additional, Morganlander, Joel, additional, Mathew, Joseph P., additional, Welsh, Stacey, additional, Casalinova, Sarah, additional, Johnson, Victoria, additional, Lane, Kathleen, additional, Smith, Derek, additional, Tipton, Greg, additional, Berry, Mark F., additional, Williams, Judson B., additional, Englum, Brian, additional, Hartwig, Matthew, additional, Guyton, Robert, additional, Lattouf, Omar, additional, Chen, Edward, additional, Vega, J. David, additional, Baer, Jefferson, additional, Nguyen, Duc, additional, Halkos, Michael, additional, Baio, Kim, additional, Prince, Tamara, additional, Cook, Natascha, additional, Neill, Alexis A., additional, Senechal, Mario, additional, Dagenais, François, additional, Laforce, Robert, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Caouette, Manon, additional, Tremblay, Hugo, additional, Gagne, Nathalie, additional, Dumont, Julie, additional, Landry, Patricia, additional, Trichon, Benjamin H., additional, Binns, Oliver A., additional, Ely, Stephen W., additional, Johnson, Alan M., additional, Hansen, Todd H., additional, Short, John G., additional, Taylor, Reid D., additional, Mangusan, Ralph, additional, Nanney, Tracy, additional, Aubart, Holly, additional, Cross, Kristin, additional, McPeters, Leslie, additional, Riggsbee, Christina, additional, Rixey, Lucy, additional, Michler, Robert E., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo A., additional, Taub, Cynthia, additional, Spevack, Daniel, additional, Kirchoff, Kathryn, additional, Meli, Rebecca, additional, Garcia, Juan, additional, Goldenberg, Jon, additional, Kealy, Lauren, additional, Bouchard, Denis, additional, Tanguay, Jean François, additional, O'Meara, Eileen, additional, Lacharité, Jonathan, additional, Robichaud, Sophie, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Kumkumian, Greg, additional, Milner, Mark, additional, Nadareishvili, Zurab, additional, Hasan, Ayesha, additional, McDavid, Asia, additional, Fadorsen, Denise, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Fumakia, Nishit, additional, Christie, Shakira, additional, Bissonauth, Asvina, additional, Hripko, Alexandra, additional, Noor, Zahid, additional, Mackowick, Kristen, additional, Deasey, Stephanie, additional, Al-Suqi, Manal, additional, Collins, Julia, additional, Acker, Michael A., additional, Messé, Steven, additional, Kirkpatrick, James, additional, Mayer, Mary Lou, additional, McDonald, Caitlin, additional, Fok, Holley, additional, Maffei, Breanna, additional, Cresse, Stephen, additional, Gepty, Christine, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Heck, Christi, additional, Hackmann, Amy, additional, Baker, Craig, additional, Fleischman, Fernando, additional, Cunningham, Mark, additional, Lozano, Edward, additional, Hernandez, Michelle, additional, Kron, Irving L., additional, Johnston, Karen, additional, Ghanta, Ravi K., additional, Dent, John M., additional, Kern, John, additional, Yarboro, Leora, additional, Ragosta, Michael, additional, Annex, Brian, additional, Bergin, Jim, additional, Burks, Sandra, additional, Cosner, Mike, additional, Green, China, additional, Loya, Samantha, additional, Kim, Hye Ryun, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Gottesman, Rebecca, additional, Haigney, Mark, additional, Holubkov, Richard, additional, Iadecola, Constantino, additional, Jacobs, Alice, additional, Meslin, Eric M., additional, Murkin, John M., additional, Spertus, John A., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Canty, John, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Kim, KyungMann, additional, Williams, David O., additional, Yancy, Clyde W., additional, Chaturvedi, Seemant, additional, Chimowitz, Marc, additional, Fang, James C., additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Miller, Rachel, additional, Cook, Jennifer, additional, D'Alessandro, David, additional, Han, Frederick, additional, Pinney, Sean, additional, Walsh, Mary N., additional, Greer, David, additional, Ishida, Koto, additional, Stapf, Christian, additional, Hung, Judy, additional, Zeng, Xin, additional, Hung, David, additional, Satitthummanid, Sudarat, additional, Billelo, Michel, additional, Davatzikos, Christos, additional, Karpf, Lauren, additional, Desiderio, Lisa, additional, Toulgoat-Dubois, Yanne, additional, Brassard, Rachele, additional, Virmanu, Renu, additional, Romero, Maria E., additional, and Braumann, Ryan, additional
Published: 2022
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26. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis

Author: Menon, Madhav C., Chuang, Peter Y., Li, Zhengzhe, Wei, Chengguo, Zhang, Weijia, Luan, Yi, Yi, Zhengzi, Xiong, Huabao, Woytovich, Christopher, Greene, Ilana, Overbey, Jessica, Rosales, Ivy, Bagiella, Emilia, Chen, Rong, Ma, Meng, Li, Li, Ding, Wei, Djamali, Arjang, Saminego, Millagros, OConnell, Philip J., Gallon, Lorenzo, Colvin, Robert, Schroppel, Bernd, He, John Cijiang, and Murphy, Barbara
Subjects: Kidneys -- Transplantation, Chronic kidney failure -- Risk factors -- Care and treatment -- Genetic aspects -- Research, Single nucleotide polymorphisms -- Research, Health care industry
Abstract: Fibrosis underlies the loss of renal function in patients with chronic kidney disease (CKD) and in kidney transplant recipients with chronic allograft nephropathy (CAN). Here, we studied the effect of an intronic SNP in SHROOM3, which has previously been linked to CKD, on the development of CAN in a prospective cohort of renal allograft recipients. The presence of the rs17319721 allele at the SHROOM3 locus in the donor correlated with increased SHROOM3 expression in the allograft. In vitro, we determined that the sequence containing the risk allele at rs17319721 is a transcription factor 7-like 2-dependent (TCF7L2-dependent) enhancer element that functions to increase SHROOM3 transcription. In renal tubular cells, TGF-β1 administration upregulated SHROOM3 expression in a β-catenin/TCF7L2-mediated manner, while SHROOM3 in turn facilitated canonical TGF-β1 signaling and increased a1 collagen (COL1A1) expression. Inducible and tubular cell-specific knockdown of Shroom3 markedly abrogated interstitial fibrosis in mice with unilateral ureteric obstruction. Moreover, SHROOM3 expression in allografts at 3 months after transplant and the presence of the SHROOM3 risk allele in the donor correlated with increased allograft fibrosis and with reduced estimated glomerular filtration rate at 12 months after transplant. Our findings suggest that rs17319721 functions as a c/s-acting expression quantitative trait locus of SHROOM3 that facilitates TGF-β1 signaling and contributes to allograft injury., Introduction Chronic kidney disease (CKD) affects 10% of adults in the US, and its incidence and prevalence are increasing worldwide (1). In addition to conferring risk for end-stage renal disease [...]
Published: 2015
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27. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation

Author: Bertrand, Philippe B., primary, Overbey, Jessica R., additional, Zeng, Xin, additional, Levine, Robert A., additional, Ailawadi, Gorav, additional, Acker, Michael A., additional, Smith, Peter K., additional, Thourani, Vinod H., additional, Bagiella, Emilia, additional, Miller, Marissa A., additional, Gupta, Lopa, additional, Mack, Michael J., additional, Gillinov, A. Marc, additional, Giustino, Gennaro, additional, Moskowitz, Alan J., additional, Gelijns, Annetine C., additional, Bowdish, Michael E., additional, O’Gara, Patrick T., additional, Gammie, James S., additional, Hung, Judy, additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard D., additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Moquete, Ellen, additional, Chang, Helena, additional, Chase, Melissa, additional, Foo, James, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, O’Sullivan, Karen, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Williams, Deborah, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Lawrence, Rita, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Blackstone, Eugene H., additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Geither, Carrie, additional, Doud, Kristen, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, Dagenais, François, additional, O’Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, Mangusan, Ralph, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Perrault, Louis P., additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Jonathan Lacharité, Sophie Robichaud, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Mullen, John C., additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Young, Cindi A., additional, Beach, Dana, additional, Villanueva, Robert, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Kilcullen, Niamh, additional, Hung, David, additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional
Published: 2021
Full Text: View/download PDF

28. Risk for non-home discharge following surgery for ischemic mitral valve disease

Author: Lala, Anuradha, primary, Chang, Helena L., additional, Liu, Xiaoyu, additional, Charles, Eric J., additional, Yerokun, Babatunde A., additional, Bowdish, Michael E., additional, Thourani, Vinod H., additional, Mack, Michael J., additional, Miller, Marissa A., additional, O'Gara, Patrick T., additional, Blackstone, Eugene H., additional, Moskowitz, Alan J., additional, Gelijns, Annetine C., additional, Mullen, John C., additional, Stevenson, Lynne W., additional, DeRose, Joseph J., additional, Wang, Alice, additional, Smith, Peter K., additional, Acker, Michael A., additional, Ailawadi, Gorav, additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard D., additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Moquete, Ellen, additional, Chang, Helena, additional, Chase, Melissa, additional, Foo, James, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, O'Sullivan, Karen, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Williams, Deborah, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Lawrence, Rita, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Gillinov, A. Marc, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Geither, Carrie, additional, Doud, Kristen, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, Dagenais, François, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, Mangusan, Ralph, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Perrault, Louis P., additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Jonathan Lacharité, Sophie Robichaud, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, Young, Cindi A., additional, Beach, Dana, additional, Villanueva, Robert, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Kilcullen, Niamh, additional, Hung, David, additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional
Published: 2021
Full Text: View/download PDF

29. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author: Ferket, Bart S., primary, Thourani, Vinod H., additional, Voisine, Pierre, additional, Hohmann, Samuel F., additional, Chang, Helena L., additional, Smith, Peter K., additional, Michler, Robert E., additional, Ailawadi, Gorav, additional, Perrault, Louis P., additional, Miller, Marissa A., additional, O'Sullivan, Karen, additional, Mick, Stephanie L., additional, Bagiella, Emilia, additional, Acker, Michael A., additional, Moquete, Ellen, additional, Hung, Judy W., additional, Overbey, Jessica R., additional, Lala, Anuradha, additional, Iraola, Margaret, additional, Gammie, James S., additional, Gelijns, Annetine C., additional, O'Gara, Patrick T., additional, Moskowitz, Alan J., additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Chang, Helena, additional, Chase, Melissa, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Blackstone, Eugene H., additional, Gillinov, A. Marc, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Senechal, Mario, additional, Dagenais, François, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, D'Alessandro, David A., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Robichaud, Sophie, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Mullen, John C., additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Young, Cindi A., additional, Beach, Dana, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Hung, Judy, additional, Zeng, Xin, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional
Published: 2020
Full Text: View/download PDF

30. Corrigendum to: Hepatitis C Seroprevalence Among Consecutive Labor and Delivery Admissions in Two New York City Hospitals

Author: Kushner, Tatyana, primary, Park, Claire, additional, Masand, Dana, additional, Wagner, Brian, additional, Grace, Marie, additional, Rosenbluth, Emma, additional, Rodriguez-Rivas, Clara, additional, de la Cruz, Hernis, additional, Overbey, Jessica, additional, and Sperling, Rhoda, additional
Published: 2021
Full Text: View/download PDF

31. Hepatitis C Seroprevalence Among Consecutive Labor and Delivery Admissions in Two New York City Hospitals

Author: Kushner, Tatyana, primary, Park, Claire, additional, Masand, Dana, additional, Wagner, Brian, additional, Grace, Marie, additional, Rosenbluth, Emma, additional, Rodriguez-Rivas, Clara, additional, de la Cruz, Hernis, additional, Overbey, Jessica, additional, and Sperling, Rhoda, additional
Published: 2020
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32. THE ASSOCIATION OF ENDOMETRIAL THICKNESS AND ENDOMETRIAL TYPE WITH IVF OUTCOMES IN A SHARED OOCYTE DONOR-RECIPIENT MODEL

Author: Aharon, Devora, primary, Stoffels, Guillaume, additional, Gounko, Dmitry, additional, Overbey, Jessica, additional, Lee, Joseph A., additional, Copperman, Alan B., additional, and Buyuk, Erkan, additional
Published: 2020
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33. EFFECT OF LONGITUDINAL STRAIN ON CLINICAL AND ECHOCARDIOGRAPHIC OUTCOMES AFTER CARDIAC SURGERY FOR MODERATE ISCHEMIC MITRAL REGURGITATION

Author: Bertrand, Philippe B., primary, Raymond, Samantha S., additional, Smith, Peter K., additional, Thourani, Vinod, additional, Ailawadi, Gorav, additional, Bagiella, Emilia, additional, Voisine, Pierre, additional, Zeng, Xin, additional, Nagata, Yasufumi, additional, Levine, Robert A., additional, Gelijns, Annetine, additional, Miller, Marissa, additional, Moskowitz, Alan, additional, Taddei-Peters, Wendy, additional, Moquete, Ellen, additional, O’Gara, Patrick T., additional, Alexander, John H., additional, Gammie, James S., additional, Yerokun, Babatunde, additional, DeRose, Joseph, additional, Overbey, Jessica, additional, and Hung, Judy, additional
Published: 2020
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34. IMPROVEMENT IN PATIENT CENTERED OUTCOMES FOLLOWING MITRAL VALVE SURGERY FOR SEVERE ISCHEMIC MITRAL REGURGITATION

Author: Lala, Anuradha (Anu), primary, Kirkwood, Katherine, additional, Iribarne, Alexander, additional, Moskowitz, Alan, additional, Overbey, Jessica, additional, Charles, Eric J., additional, Goldstein, Daniel J., additional, O’Gara, Patrick T., additional, Puskas, John, additional, Bagiella, Emilia, additional, Taddei-Peters, Wendy, additional, O'sullivan, Karen, additional, Miller, Marissa, additional, Laurin, Charles, additional, Giustino, Gennaro, additional, Yerokun, Babatunde, additional, Gillinov, A., additional, Gelijns, Annetine, additional, Acker, Michael, additional, and Stevenson, Lynne, additional
Published: 2020
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35. Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation

Author: DeRose, Joseph J., primary, Mancini, Donna M., additional, Chang, Helena L., additional, Argenziano, Michael, additional, Dagenais, François, additional, Ailawadi, Gorav, additional, Perrault, Louis P., additional, Parides, Michael K., additional, Taddei-Peters, Wendy C., additional, Mack, Michael J., additional, Glower, Donald D., additional, Yerokun, Babatunde A., additional, Atluri, Pavan, additional, Mullen, John C., additional, Puskas, John D., additional, O’Sullivan, Karen, additional, Sledz, Nancy M., additional, Tremblay, Hugo, additional, Moquete, Ellen, additional, Ferket, Bart S., additional, Moskowitz, Alan J., additional, Iribarne, Alexander, additional, Gelijns, Annetine C., additional, O’Gara, Patrick T., additional, Blackstone, Eugene H., additional, Gillinov, A. Marc, additional, Miller, Marissa A., additional, Buxton, Dennis, additional, Connolly, Amy, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Chang, Helena, additional, Chase, Melissa, additional, Dobrev, Edlira, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Levitan, Ron, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Blackwell, Ray, additional, Kerzner, Roger, additional, Banbury, Michael, additional, Squire, Andrea M., additional, Lytle, Bruce, additional, Mihaljevic, Tomislav, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Smith, Peter K., additional, Alexander, John H., additional, Milano, Carmelo A., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Thourani, Vinod H., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, O’Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevack, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismael, additional, Denault, André, additional, Lacharité, Jonathan, additional, Robichaud, Sophie, additional, Adams, David H., additional, Varghese, Robin, additional, Mandel-Portnoy, Yael, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, DeFilippi, Christopher R., additional, Gaetani, Dino T., additional, Young, Cindi A., additional, Beach, Dana, additional, Collins, Julia, additional, Bolling, Steven F., additional, Pagani, Francis D., additional, Bloem, Cathie, additional, Acker, Michael A., additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bavaria, Joseph E., additional, Szeto, Wilson Y., additional, Margulies, Kenneth, additional, Keane, Martin, additional, Glassberg, Helene, additional, Jagasia, Dinesh, additional, Kirkpatrick, James, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Mangi, Abeel, additional, Akar, Joseph, additional, Yuh, David, additional, Wilson, Lynn, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Canty, John M., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Couderc, Jean-Philippe, additional, Balda, Dan, additional, Bowen, Wayne, additional, Wilson, Mauri, additional, and Schering, Anne, additional
Published: 2019
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36. SEX-BASED DIFFERENCES IN OUTCOMES AFTER MITRAL VALVE SURGERY FOR SEVERE ISCHEMIC MITRAL REGURGITATION: FROM THE CARDIOTHORACIC SURGICAL TRIALS NETWORK

Author: Giustino, Gennaro, primary, Overbey, Jessica, additional, Taylor, Doris, additional, Ailawadi, Gorav, additional, Kirkwood, Katherine, additional, Gillinov, A., additional, Dagenais, François, additional, Mayer, Mary-Lu, additional, Gelijns, Annetine, additional, Moskowitz, Alan, additional, Bagiella, Emilia, additional, Miller, Marissa, additional, Smith, Peter, additional, O'Gara, Patrick, additional, Acker, Michael, additional, Lala-Trindade, Anuradha (Anu), additional, and Hung, Judy, additional
Published: 2019
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37. Pelvic pain and early IUD discontinuation: a prospective cohort study

Author: Gerber, Sharon R., primary, Natell, Noah, additional, Doty, Nora, additional, Liu, Xiaoyu, additional, Overbey, Jessica R., additional, and Masch, Rachel, additional
Published: 2019
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38. FXI Deficiency Found on Expanded Carrier Screening: A Quandry in Routine Obstetric Management

Author: Chu Lam, Melissa, primary, Viola, Justine, additional, Taylor, Dyese, additional, Hussain, Farrah, additional, Overbey, Jessica, additional, Pan, Stephanie, additional, Cole, David, additional, and Rosenn, Barak, additional
Published: 2019
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39. Cell-Free DNA: How Much Do Patients Actually Know?

Author: Chu Lam, Melissa, primary, Parikh, Reena, additional, Taylor, Dyese, additional, Hussain, Farrah, additional, Overbey, Jessica, additional, Pan, Stephanie, additional, and Al-Ibraheemi, Zainab, additional
Published: 2019
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40. Biatrial maze procedure versus pulmonary vein isolation for atrial fibrillation during mitral valve surgery: New analytical approaches and end points

Author: Blackstone, Eugene H., primary, Chang, Helena L., additional, Rajeswaran, Jeevanantham, additional, Parides, Michael K., additional, Ishwaran, Hemant, additional, Li, Liang, additional, Ehrlinger, John, additional, Gelijns, Annetine C., additional, Moskowitz, Alan J., additional, Argenziano, Michael, additional, DeRose, Joseph J., additional, Couderc, Jean-Phillipe, additional, Balda, Dan, additional, Dagenais, François, additional, Mack, Michael J., additional, Ailawadi, Gorav, additional, Smith, Peter K., additional, Acker, Michael A., additional, O'Gara, Patrick T., additional, Gillinov, A. Marc, additional, Miller, Marissa A., additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Connolly, Amy, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Moquete, Ellen, additional, Chang, Helena, additional, Chase, Melissa, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Kumbarce, Edlira, additional, Levitan, Ron, additional, O'Sullivan, Karen, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Blackwell, Ray, additional, Kerzner, Roger, additional, Banbury, Michael, additional, Squire, Andrea M., additional, Blackstone, Eugene H., additional, Lytle, Bruce, additional, Mihaljevic, Tomislav, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Thourani, Vinod H., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevack, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Perrault, Louis P., additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismael, additional, Denault, André, additional, Lacharité, Jonathan, additional, Robichaud, Sophie, additional, Adams, David H., additional, Varghese, Robin, additional, Mandel-Portnoy, Yael, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Mullen, John C., additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, DeFilippi, Christopher R., additional, Gaetani, Dino T., additional, Young, Cindi A., additional, Beach, Dana, additional, Collins, Julia, additional, Bolling, Steven F., additional, Pagani, Francis D., additional, Bloem, Cathie, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bavaria, Joseph E., additional, Szeto, Wilson Y., additional, Margulies, Kenneth, additional, Keane, Martin, additional, Glassberg, Helene, additional, Jagasia, Dinesh, additional, Kirkpatrick, James, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Mangi, Abeel, additional, Akar, Joseph, additional, Yuh, David, additional, Wilson, Lynn, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Canty, John M., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Couderc, Jean-Philippe, additional, Bowen, Wayne, additional, Wilson, Mauri, additional, and Schering, Anne, additional
Published: 2019
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41. Porphyria Cutanea Tarda: Profile of 189 Patients from the Porphyrias Consortium in the United States

Author: Singal, Ashwani K., primary, Naik, Hetanshi, additional, Overbey, Jessica R., additional, Balwani, Manisha, additional, Liu, Lawrence, additional, Wang, Bruce, additional, Parker, Charles, additional, Keel, Sioban, additional, Erwin, Angelika, additional, Levy, Cynthia, additional, Bloomer, Joseph R., additional, Arora, Sumant, additional, Bissell, Dwight M., additional, Bonkovsky, Herbert L., additional, Phillips, John, additional, Desnick, Robert, additional, and Anderson, Karl E., additional
Published: 2017
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42. Impact of Left Ventricular to Mitral Valve Ring Mismatch on Recurrent Ischemic Mitral Regurgitation After Ring Annuloplasty

Author: Capoulade, Romain, primary, Zeng, Xin, additional, Overbey, Jessica R., additional, Ailawadi, Gorav, additional, Alexander, John H., additional, Ascheim, Deborah, additional, Bowdish, Michael, additional, Gelijns, Annetine C., additional, Grayburn, Paul, additional, Kron, Irving L., additional, Levine, Robert A., additional, Mack, Michael J., additional, Melnitchouk, Serguei, additional, Michler, Robert E., additional, Mullen, John C., additional, O’Gara, Patrick, additional, Parides, Michael K., additional, Smith, Peter, additional, Voisine, Pierre, additional, and Hung, Judy, additional
Published: 2016
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43. Hybrid Coronary Revascularization for the Treatment of Multivessel Coronary Artery Disease

Author: Puskas, John D., primary, Halkos, Michael E., additional, DeRose, Joseph J., additional, Bagiella, Emilia, additional, Miller, Marissa A., additional, Overbey, Jessica, additional, Bonatti, Johannes, additional, Srinivas, V.S., additional, Vesely, Mark, additional, Sutter, Francis, additional, Lynch, Janine, additional, Kirkwood, Katherine, additional, Shapiro, Timothy A., additional, Boudoulas, Konstantinos D., additional, Crestanello, Juan, additional, Gehrig, Thomas, additional, Smith, Peter, additional, Ragosta, Michael, additional, Hoff, Steven J., additional, Zhao, David, additional, Gelijns, Annetine C., additional, Szeto, Wilson Y., additional, Weisz, Giora, additional, Argenziano, Michael, additional, Vassiliades, Thomas, additional, Liberman, Henry, additional, Matthai, William, additional, and Ascheim, Deborah D., additional
Published: 2016
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44. Identification of Polymorphic Gnpat As a Risk Factor for Porphyria Cutanea Tarda

Author: Phillips, John D, primary, Farrell, Colin P, additional, Overbey, Jessica, additional, Naik, Hetanshi, additional, McLaren, Gordon D., additional, McLaren, Christine E, additional, Zhou, Luming, additional, and Parker, Charles J., additional
Published: 2015
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45. Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma

Author: Leshchenko, Violetta V., primary, Kuo, Pei-Yu, additional, Jiang, Zewei, additional, Weniger, Marc A., additional, Overbey, Jessica, additional, Dunleavy, Kieron, additional, Wilson, Wyndham H., additional, Wiestner, Adrian, additional, and Parekh, Samir, additional
Published: 2015
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46. Mo1363 - Porphyria Cutanea Tarda: Profile of 189 Patients from the Porphyrias Consortium in the United States

Author: Singal, Ashwani K., Naik, Hetanshi, Overbey, Jessica R., Balwani, Manisha, Liu, Lawrence, Wang, Bruce, Parker, Charles, Keel, Sioban, Erwin, Angelika, Levy, Cynthia, Bloomer, Joseph R., Arora, Sumant, Bissell, Dwight M., Bonkovsky, Herbert L., Phillips, John, Desnick, Robert, and Anderson, Karl E.
Published: 2017
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47. Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis

Author: Menon, Madhav C., primary, Chuang, Peter Y., additional, Li, Zhengzhe, additional, Wei, Chengguo, additional, Zhang, Weijia, additional, Luan, Yi, additional, Yi, Zhengzi, additional, Xiong, Huabao, additional, Woytovich, Christopher, additional, Greene, Ilana, additional, Overbey, Jessica, additional, Rosales, Ivy, additional, Bagiella, Emilia, additional, Chen, Rong, additional, Ma, Meng, additional, Li, Li, additional, Ding, Wei, additional, Djamali, Arjang, additional, Saminego, Millagros, additional, O’Connell, Philip J., additional, Gallon, Lorenzo, additional, Colvin, Robert, additional, Schroppel, Bernd, additional, He, John Cijiang, additional, and Murphy, Barbara, additional
Published: 2014
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48. INTERVENTIONAL CARDIOLOGISTS AND CARDIAC SURGEONS: CONCORDANCE REGARDING ANATOMIC ELIGIBILITY FOR HYBRID CORONARY REVASCULARIZATION IN > 6,500 PATIENTS

Author: DeRose, Joseph J., primary, Liberman, Henry, additional, Matthai, William, additional, Szeto, Wilson, additional, Parides, Michael, additional, Srinivas, Vankeepuram, additional, Bonatti, Johannes, additional, Overbey, Jessica, additional, Vesely, Mark, additional, Sutter, Francis, additional, Williams, Paula, additional, Shapiro, Timothy, additional, Crestanello, Juan, additional, Boudoulas, Konstantinos, additional, Smith, Peter, additional, Gehrig, Thomas, additional, Ailawadi, Gorav, additional, Davidson, Michael, additional, Zhao, David, additional, Argenziano, Michael, additional, Williams, Mathew, additional, Puskas, John, additional, Halkos, Michael, additional, and Ascheim, Deborah, additional
Published: 2013
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49. Abstract 11933: Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network

Author: Bertrand, Philippe, Zeng, Xin, Overbey, Jessica R, Ailawadi, Gorav, Acker, Michael A, Smith, Peter K, Thourani, Vinod H, Bagiella, Emilia, Miller, Marissa, Gupta, Lopa, Mack, Michael J, Gillinov, A. Marc, Giustino, Gennaro, Moskowitz, Alan J, Gelijns, Annetine C, Bowdish, Michael, O?Gara, Patrick T, Gammie, James S, and Hung, Judy
Abstract: Introduction:Whether to repair non-severe tricuspid regurgitation (TR) in patients undergoing surgery for ischemic mitral regurgitation (IMR) is an open question. We investigated the incidence, predictors and clinical significance of TR progression and >moderate TR at 2 years.Methods:492 patients with untreated ? moderate TR who received surgery for IMR in 2 trials were included: in the moderate IMR trial patients received CABG?MV repair and in the severe IMR trial patients received MV repair or replacement (? CABG). Echo outcomes were analyzed by a core lab. The key echo outcomes were TR progression from baseline (surgery for TR/progression of TR by ?2 grades or severe TR at 2 years) and presence of ? moderate TR at 2 years.Results:Mean patient age was 66?10 years (67% male). Baseline distribution of TR was 60% ? trace, 31% mild and 9% moderate. Tricuspid annular size was 38.3?5.2mm. Baseline annular dilation (? 40mm or 21mm/m2) was present in 55% of patients. Among 2-year survivors, TR progression was observed in only 20/325 (6%) patients. Baseline annular dimension (indexed or not) was a poor predictor of progression (AUC ? 0.58). At 2 years, 37/323 (11%) patients had ? moderate TR (2 patients were excluded due to interim TR surgery). Baseline TR grade, indexed tricuspid annular dimension and concomitant maze were associated with ? moderate TR at 2 years. However, annular dimension alone (indexed or not) had poor discrimination (AUC ?0.65). Patients with ?moderate TR at 2 years had higher incidence of MR recurrence and permanent pacemakers/ICDs (Table). Higher clinical event rates (composite of ?1 NYHA class increase, HF hospitalizations, MV surgery, stroke) were observed in patients with TR progression (p=0.003) and ? moderate TR at 2 years (p=0.04).Conclusions:After IMR surgery, progression of unrepaired non-severe TR is uncommon and not predicted by baseline annular dilation. TR progression and the presence of ?moderate TR at 2 years are associated with high adverse events.
Published: 2019
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50. Abstract 15757: Association of Ischemic Mitral Regurgitation Proportionality With Outcomes After Mitral Valve Surgery: A Cardiothoracic Surgical Trials Network Analysis

Author: Giustino, Gennaro, Overbey, Jessica, O?Gara, Patrick T, Gelijns, Annetine C, Stevenson, Lynne W, Moskowitz, Alan J, Voisine, Pierre, Mack, Michael J, Acker, Michael A, Gillinov, A. Marc, Mancini, Donna M, Bagiella, Emilia, Lala, Anuradha, Woo, Y. Joseph, Hung, Judy, and Grayburn, Paul A
Abstract: Introduction:The severity of secondary mitral regurgitation (MR) relative to left ventricular (LV) volume might predict the clinical response to treatments directed to either the mitral valve (MV) or to the left ventricle. Whether this concept applies to MV surgery for severe ischemic MR (SIMR) is unknown.Methods:We evaluated the outcomes of patients with SIMR according to the baseline effective regurgitant orifice area (EROA)-to-LV end-diastolic volume (LVEDV) ratio (divided into tertiles) enrolled in a randomized trial comparing surgical MV replacement versus repair +/- CABG. Patients were followed for 2 years. Endpoints were all-cause mortality, major adverse cardiac and cerebrovascular events (MACCE), and the mean percent changes in LVEDV and end-systolic volume (LVESV) from baseline through 2 years assessed by an echo core-lab.Results:A total of 240 patients out of 251 randomized were included. Baseline characteristics across tertiles of EROA/LVEDV ratio are reported in the table. Compared with patients in tertile 1 (lowest ratio), those in tertile 3 (highest ratio) had higher risk of 2-year all-cause mortality (15% vs. 28.8%; adjusted HR: 2.98; 95% CI: 1.38-6.47) and MACCE (40% vs. 47.5%; adjusted HR: 1.95; 95% CI: 1.15-3.31). The extent of reverse LV remodeling at 2 years was greatest in patients in the lowest tertile (table), especially among those who underwent concomitant CABG.Conclusions:Patients with SIMR and highest tertile EROA/LVEDV ratios had greater risk of mortality after MV surgery. Greater degrees of reverse LV remodeling were observed in patients with lower ratios. Further research is needed to evaluate whether surgical interventions alter the relationship between proportionality of SIMR and outcomes.
Published: 2019
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