1. High- and low-Molecular Weight oat Beta-Glucan Reveals Antitumor Activity in Human Epithelial Lung Cancer.
- Author
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Choromanska A, Kulbacka J, Harasym J, Oledzki R, Szewczyk A, and Saczko J
- Subjects
- Antioxidants pharmacology, Cell Survival, Hemolysis drug effects, Humans, Lipid Peroxidation drug effects, Lung Neoplasms drug therapy, Lung Neoplasms metabolism, Male, Middle Aged, Molecular Weight, Neoplasms, Glandular and Epithelial drug therapy, Neoplasms, Glandular and Epithelial metabolism, Tumor Cells, Cultured, Antineoplastic Agents pharmacology, Avena chemistry, Lung Neoplasms pathology, Neoplasms, Glandular and Epithelial pathology, beta-Glucans pharmacology
- Abstract
Beta-glucans are widely used in treatment, cosmetics, and the food industry. Glucans play a significant role in activation of the immune and antioxidant system and inhibiting tumor proliferation. In the current study the antitumor activities of new high and low molecular weight beta-glucan derived from oats were investigated in two human lung cancer cell line (A549, H69AR) and normal keratinocytes (HaCaT). The effect of high and low molecular weight beta-glucan from oat was evaluated by cellular viability assessment, lipid peroxidation and manganese superoxide dismutase evaluation and cytoskeleton visualisation. Additionally the level of red blood cells hemolysis was performed. Our results indicate strong anti-tumor properties of new beta-glucan from oat and at the same time no toxicity for normal cells.
- Published
- 2018
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