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105 results on '"Ohmori, Koji"'

1. Intracoronary administration of nicorandil during primary percutaneous coronary intervention: Impact on restoration of regional myocardial perfusion in reperfused myocardium during the subacute phase of myocardial infarction

Author

Takabatake, Wataru, Noma, Takahisa, Iwado, Yasuyoshi, Ishikawa, Shohei, Tobiume, Atsushi, Hasui, Yusuke, Matsunaga, Keiji, Mantani, Kaoru, Konishi, Kumi, Kawakami, Ryo, Ishihara, Naoko, Ishihara, Yasuhiro, Ishizawa, Makoto, Ishikawa, Kaori, Murakami, Kazushi, Ohmori, Koji, Nishiyama, Yoshihiro, and Kohno, Masakazu

Published
2015
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7. Prognostic Value of Circulating Regulatory T Cells for Worsening Heart Failure in Heart Failure Patients With Reduced Ejection Fraction

Author

Okamoto, Naoko, primary, Noma, Takahisa, additional, Ishihara, Yasuhiro, additional, Miyauchi, Yuka, additional, Takabatake, Wataru, additional, Oomizu, Souichi, additional, Yamaoka, Genji, additional, Ishizawa, Makoto, additional, Namba, Tsunetatsu, additional, Murakami, Kazushi, additional, Iwado, Yasuyoshi, additional, Ohmori, Koji, additional, and Kohno, Masakazu, additional

Published
2014
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8. Calcium Channel Blocker Enhances Beneficial Effects of an Angiotensin II AT1 Receptor Blocker against Cerebrovascular-Renal Injury in type 2 Diabetic Mice

Author

Rafiq, Kazi, primary, Sherajee, Shamshad J., additional, Hitomi, Hirofumi, additional, Nakano, Daisuke, additional, Kobori, Hiroyuki, additional, Ohmori, Koji, additional, Mori, Hirohito, additional, Kobara, Hideki, additional, Masaki, Tsutomu, additional, Kohno, Masakazu, additional, and Nishiyama, Akira, additional

Published
2013
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10. Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I^|^ndash;Infused Rats

Author

Ohnishi, Keisuke, primary, Murase, Miki, additional, Nakano, Daisuke, additional, Pelisch, Nicolas, additional, Hitomi, Hirofumi, additional, Kobori, Hiroyuki, additional, Morimoto, Satoshi, additional, Mori, Hirohito, additional, Masaki, Tsutomu, additional, Ohmori, Koji, additional, Kohno, Masakazu, additional, Ichihara, Atsuhiro, additional, and Nishiyama, Akira, additional

Published
2013
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11. Abstract 9608: Intracoronary Administration of Nicorandil During Direct Coronary Stenting Complements Restoration of Regional Perfusion at Subacute Phase of Myocardial Infarction: A Demonstration With O-15 Water Pet

Author

Takabatake, Wataru, primary, Iwado, Yasuyoshi, additional, Ishikawa, Kaori, additional, Miyauchi, Yuka, additional, Tada, Kumi, additional, Murakami, Kazushi, additional, Noma, Takahisa, additional, Ohmori, Koji, additional, Nisiyama, Yosihiro, additional, and Kohno, Masakazu, additional

Published
2012
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13. Positron Emission Tomographic Demonstration of Myocardial Oxidative Metabolism in a Case of Left Ventricular Restoration After Cardiac Resynchronization Therapy

Author

Kitaizumi, Kenji, primary, Yukiiri, Kazushi, additional, Masugata, Hisashi, additional, Shinomiya, Kaori, additional, Ohara, Minako, additional, Takinami, Hiroyuki, additional, Iwado, Yasuyoshi, additional, Yoshida, Junji, additional, Noma, Takahisa, additional, Ohmori, Koji, additional, Yamashita, Yoichi, additional, Horii, Taiko, additional, Senda, Shoich, additional, and Kohno, Masakazu, additional

Published
2008
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16. Sand banks contribute to the production of coastal waters by making a habitat for benthic microalgae in the sublittoral zone: food web analyses in Aki-Nada using stable isotopes

Author

Yoshino, Kenji, primary, Miyasaka, Hitoshi, additional, Kawamura, Yuji, additional, Genkai-Kato, Motomi, additional, Okuda, Noboru, additional, Hayami, Yuichi, additional, Ito, Sayaka, additional, Fukumori, Kayoko, additional, Sekiguchi, Tomohiro, additional, Ohnishi, Hidejiro, additional, Ohmori, Koji, additional, and Takeoka, Hidetaka, additional

Published
2006
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19. Evaluation of dynamic changes in microvascular flow during ischemia-reperfusion by myocardial contrast echocardiography

Author

Galiuto, Leonarda, De Maria, Anthony N, May Newman, Karen, Del Balzo, Ughetta, Ohmori, Koji, Bhargava, Valmik, Flaim, Stephen F, Iliceto, Sabino, Galiuto, Leonarda (ORCID:0000-0002-6831-479X), Galiuto, Leonarda, De Maria, Anthony N, May Newman, Karen, Del Balzo, Ughetta, Ohmori, Koji, Bhargava, Valmik, Flaim, Stephen F, Iliceto, Sabino, and Galiuto, Leonarda (ORCID:0000-0002-6831-479X)

Abstract

Dynamic changes of myocardial blood flow have been observed after reperfusion of an occluded coronary artery. MCE performed by intracoronary contrast injection can provide an estimate of microvascular flow. We hypothesized that MCE performed using intravenous infusion of a new generation contrast agent and electrocardiogram-gated harmonic imaging would be able to assess serial changes of microvascular perfusion. OBJECTIVE: To study the potential of myocardial contrast echocardiography (MCE) to assess serial changes of microvascular flow during ischemia-reperfusion. METHODS: Sixteen dogs underwent 90 or 180 min of left anterior descending coronary occlusion, followed by 180 min of reperfusion. Regional blood flow (RBF) was measured with fluorescent microspheres at baseline, during coronary occlusion, and at 5, 30, 90, and 180 min during reperfusion. At the same time points, MCE was performed with intravenous infusion of AF0150 (4 mg/min). Gated end-systolic images in short axis were acquired in harmonic mode and digitized on-line. Background-subtracted videointensity measured from MCE and RBF obtained from fluorescent microspheres were calculated for the risk area and for a control area, and were expressed as the ratio of the two areas. RESULTS: After initial hyperemia, a progressive reduction in flow was observed during reperfusion. MCE correctly detected the time course of changes in flow during occlusion-reperfusion. Videointensity ratio significantly correlated with RBF data (r=0.79; p < 0.0001). CONCLUSIONS: The progressive reduction in blood flow occurring within the postischemic microcirculation was accurately detected by MCE. This approach has potential application in the evaluation and management of postischemic reperfusion in humans

Published
1998

24. Albumin microbubbles can be targeted to activated neutrophils in vivo: application to assessment of the neutrophils infiltration pattern produced by ischemia/reperfusion

Author

Kondo, Isao, primary, Ohmori, Koji, additional, Oshita, Akira, additional, Takeuchi, Hiroto, additional, Shinomiya, Kaori, additional, Yu, Yang, additional, Takagi, Yuichiro, additional, Yukiiri, Kazushi, additional, Wada, Yoshihiro, additional, Mizushige, Katsufumi, additional, and Kohno, Masakazu, additional

Published
2002
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33. Fulminant Myocarditis in Polymyositis.

Author

Yukiiri, Kazushi, primary, Mizushige, Katsufumi, additional, Ueda, Takashi, additional, Nanba, Tsunetatsu, additional, Tanimoto, Kojiro, additional, Wada, Yoshihiro, additional, Takagi, Yuichiro, additional, Ohmori, Koji, additional, and Kohno, Masakazu, additional

Published
2001
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45. Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases.

Author

Guo-Xing Zhang, Nagai, Yukiko, Nakagawa, Toshitaka, Miyanaka, Hiroshi, Fujisawa, Yoshihide, Nishiyama, Akira, Izuishi, Kunihiko, Ohmori, Koji, and Kimura, Shoji

Subjects
ANGIOTENSINS, MITOGEN-activated protein kinases, OXIDATION-reduction reaction, NITRIC-oxide synthases, CARDIOVASCULAR system
Abstract

Angiotensin II (ANG II) is a powerful activator of mitogen-activated protein (MAP) kinase cascades in cardiovascular tissues through a redox-sensitive mechanism. Nitric oxide (NO) is considered to antagonize the vasoconstrictive and proarteriosclerotic actions of ANG II. However, the role of endogenous NO in ANG II-induced redox-sensitive signal transduction is not yet clear. In this study using catheterized, conscious rats, we found that acute intravenous administration of MG-nitro-L-arginine methyl ester (L-NAME; 5 mg/kg) enhanced phosphorylation of aortic MAP kinases extracellular signal regulated kinase (ERK) 1/2 and p38, which were suppressed only partially by a superoxide dismutase mimetic (Tempol), whereas ANG II-induced MAP kinase phosphorylation was markedly suppressed by Tempol. FK409, a NO donor, had little effect on vascular MAP kinase phosphorylation. On the other hand, acute exposure to a vasoconstrictor dose of ANG II (200 ng·kg-1·min-1 iv) failed to enhance phosphorylation of aortic MAP kinases in the chronically L-NAME-treated rats, whereas the vasoconstrictor effect of ANG II was not affected by L-NAME treatment. Furthermore, three different inhibitors of NO synthase suppressed, in a dose-dependent manner, ANG II-induced MAP kinase phosphorylation in rat vascular smooth muscle cells, which was closely linked to superoxide generation in cells. These results indicate the involvement of endogenous NO synthase in ANG II-induced signaling pathways, leading to activation of MAP kinase, and that NO may have dual effects on the vascular MAP kinase activation associated with redox sensitivity. [ABSTRACT FROM AUTHOR]

Published
2007
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46. Potentiation of C-type natriuretic peptide with ultrasound and microbubbles to prevent neointimal formation after vascular injury in rats

Author

Takeuchi, Hiroto, Ohmori, Koji, Kondo, Isao, Oshita, Akira, Shinomiya, Kaori, Yu, Yang, Takagi, Yuichiro, Mizushige, Katsufumi, Kangawa, Kenji, and Kohno, Masakazu

Subjects
*ATRIAL natriuretic peptides, *CORONARY restenosis, *SMOOTH muscle
Abstract

Objectives: Long-term intravenous infusion of high-dose C-type natriuretic peptide (CNP) is known to prevent neointimal formation after vascular injury. Ultrasound (US) irradiation during microbubbles (MBs) infusion (US/MBs) has been used for local delivery of bioactive agents. We examined whether short-term infusion of CNP could also inhibit neointimal development and whether combined US/MBs treatment at the beginning of the CNP infusion could enhance its effect. Methods: In the rat carotid artery-balloon injury model, the intima/media area (I/M) ratio 14 days after injury was compared among various short-term post-injury treatments. For combined US/MBs, a commercial echocardiograph (1.8 MHz, mechanical index 1.0) and albumin-coated octafluoropropane gas MBs were used. Results: Infusion of high-dose CNP (1.0 μg/kg/min) immediately after injury for only 24 h successfully reduced the I/M ratio (0.18±0.05) to 18% of the ratio in control rats (1.00±0.13) that underwent only balloon injury. Although low-dose CNP (0.1 μg/kg/min for 24 h) alone was not effective in reducing the I/M ratio (0.83±0.18), combined US/MBs treatment for the first 80 min of the infusion markedly reduced the I/M ratio (0.17±0.07), which persisted until 28 days after injury (0.16±0.04). Conclusions: The effects of CNP on the events occurring early after arterial injury may be important in preventing subsequent neointimal development. Thus, intravenous infusion of CNP with US/MBs at its initiation may provide a clinically feasible anti-restenosis therapy applicable immediately after vascular interventions. [Copyright &y& Elsevier]

Published
2003
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47. Correlation of functional and structural alterations of the coronary arterioles during development of type II diabetes mellitus in rats

Author

Yu, Yang, Ohmori, Koji, Kondo, Isao, Yao, Li, Noma, Takahisa, Tsuji, Teppei, Mizushige, Katsufumi, and Kohno, Masakazu

Subjects
*HEART abnormalities, *DIABETES, *CORONARY circulation, *HEART fibrosis
Abstract

Objective: Cardiac complications in diabetes mellitus (DM) are frequently ascribed to microangiopathy. Therefore, we sought to directly correlate the serial changes in coronary arterial function with the extent of coronary arteriolar remodeling in a model spontaneously developing type II DM. Methods: Otsuka Long-Evans Tokushima Fatty (OLETF) rats and control Long-Evans Tokushima Otsuka (LETO) rats were used. At 5, 15 and 30 weeks of age, ten rats in each group were subjected to systemic and coronary hemodynamic measurements using the colored microsphere technique before and during maximal coronary hyperemia and histological assessment with Azan-Mallory stain of the coronary arterioles. Results: As early as 15 weeks of age, at which time fasting plasma glucose concentration remained normal, OLETF rats exhibited a lower coronary flow reserve and a greater coronary vascular resistance during hyperemia than did LETO rats. On histomorphometry, OLETF rats exhibited a greater wall-to-lumen ratio and a greater degree of perivascular fibrosis of arterioles at 15 weeks of age and thereafter, both of which exhibited a significant correlation with the minimal coronary vascular resistance. Conclusions: The degree of functional deterioration in coronary circulation was directly correlated with the severity of coronary arteriolar structural remodeling during the development of microangiopathy in early stage of DM. [Copyright &y& Elsevier]

Published
2002

48. Treatment of Acute Myocardial Infarction by Hepatocyte Growth Factor Gene Transfer The First Demonstration of Myocardial Transfer of a 'Functional' Gene Using Ultrasonic Microbubble Destruction

Author

Kondo, Isao, Ohmori, Koji, Oshita, Akira, Takeuchi, Hiroto, Fuke, Sachiko, Shinomiya, Kaori, Noma, Takahisa, Namba, Tsunetatsu, and Kohno, Masakazu

Abstract

ObjectivesWe examined whether ultrasonic microbubble destruction (US/MB) enables therapeutic myocardial gene transfer of hepatocyte growth factor (HGF) for acute myocardial infarction (MI).BackgroundHepatocyte growth factor gene transfer provides cardioprotective effects in MI, which requires direct intramyocardial injection or special vectors. Although US/MB was used in myocardial gene transfer, its feasibility in transfer of a therapeutic gene with non-viral vector remains unknown.MethodsIn a rat model of acute MI, naked plasmid (pVax1) encoding human HGF (1,500 μg) was infused into the left ventricular (LV) chamber during US/MB (HGF-US/MB) or insonation only (HGF-US) or alone (HGF-alone), while control MI rats received empty pVax1 during US/MB (pVax1-US/MB). For US/MB, transthoracic intermittent insonation with a diagnostic transducer (1.3 MHz) was performed for 2 min at a peak negative pressure of −2,160 kPa during intravenous 20% Optison.ResultsBaseline risk area was comparable among the groups. Immunohistology seven days after treatment revealed significant myocardial expression of HGF protein only in HGF-US/MB. At three weeks, LV weight in HGF-US/MB (0.89 ± 0.03 g) was significantly lower than those in HGF-alone (1.09 ± 0.08 g), HGF-US (1.04 ± 0.07 g), and pVax1-US/MB (1.04 ± 0.05 g). Moreover, scar size was significantly smaller (16 ± 6% vs. 39 ± 5%, 41 ± 6%, and 40 ± 4% of total myocardial circumferential length, respectively), while capillary density (49 ± 8 vs. 34 ± 5, 37 ± 6, and 36 ± 4 capillaries/high-power field, respectively) and arterial density (37 ± 7 vs. 15 ± 9, 18 ± 4, and 14 ± 11 arterioles/high-power field, respectively) in the risk area were higher in HGF-US/MB than the other groups.ConclusionsUltrasound-mediated microbubble destruction may enable myocardial HGF gene transfer with systemic administration of naked plasmid, which enhances angiogenesis, limits infarction size, and prevents LV remodeling after MI.

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