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9. Frequent toothbrushing boosts resilience among children in poverty: results from a population-based longitudinal study.

Author

Suzuki, Ayako, Tani, Yukako, Isumi, Aya, Ogawa, Takuya, Moriyama, Keiji, and Fujiwara, Takeo

Subjects
PSYCHOLOGICAL resilience, INCOME, RESEARCH funding, ELEMENTARY schools, DESCRIPTIVE statistics, LONGITUDINAL method, HEALTH behavior, SCHOOL children, TOOTH care & hygiene, CHILDREN'S dental care, POVERTY, ORAL health
Abstract

Background: Poverty negatively impacts beneficial aspects of mental development, such as resilience. Toothbrushing, an oral health behavior, has the potential to protect children's resilience through its anti-inflammatory and self-management effects and may be more effective for children, especially children in poverty. This study investigated whether toothbrushing boosts resilience among children, especially children under poverty, and modifies the association between poverty and resilience using a longitudinal population sample of school children. Methods: Data from the Adachi Child Health Impact of Living Difficulty (A-CHILD Study) were analyzed. A baseline study was conducted in 2015 in which the children were in first grade and followed through fourth grade (N = 3459, response rate: 80%, follow-up rate: 82%). Poverty was assessed by material deprivation (life-related deprivation and child-related deprivation) and annual household income at baseline. Children's toothbrushing frequency was assessed at baseline and classified into less than twice a day or twice or more a day. Children's resilience was assessed at baseline and follow-up using the Children's Resilient Coping Scale (range 0-100). Results: Children who brushed their teeth twice or more a day in first grade had 3.50 points greater resilience scores in fourth grade than those who brushed their teeth less than twice a day in first grade. After adjusting for confounders, including resilience in first grade, among underpoverty children, those who brushed their teeth twice or more a day in first grade had higher resilience scores [2.66 (95% CI = 0.53, 4.79)] than those who brushed their teeth less than twice a day. Among nonpoverished children, toothbrushing frequency in first grade did not significantly correlate with resilience in fourth grade. Conclusions: The beneficial effect of toothbrushing twice or more a day on resilience was more significant among children in poverty than among those without poverty in elementary school in Japan. Health policy focused on frequent toothbrushing may contribute to boosting resilience among children living in poverty. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Structural factors governing binding of curvature-sensing peptides to bacterial extracellular vesicles covered with hydrophilic polysaccharide chains

Author

Kawano, Kenichi, Kamasaka, Kouhei, Yokoyama, Fumiaki, Kawamoto, Jun, Ogawa, Takuya, Kurihara, Tatsuo, and Matsuzaki, Katsumi

Subjects
Curvature-sensing peptides, Organic Chemistry, Biophysics, Extracellular vesicles, Structural flexibility, Conformational change, Biochemistry, Coil-to-α-helix transition, Stapled peptides
Abstract

Extracellular vesicles (EVs) have attracted an attention as important targets in the fields of biology and medical science because they contain physiologically active molecules. Curvature-sensing peptides are currently used as novel tools for marker-independent EV detection techniques. A structure-activity correlation study demonstrated that the α-helicity of the peptides is prominently involved in peptide binding to vesicles. However, whether a flexible structure changing from a random coil to an α-helix upon binding to vesicles or a restricted α-helical structure is an important factor in the detection of biogenic vesicles is still unclear. To address this issue, we compared the binding affinities of stapled and unstapled peptides for bacterial EVs with different surface polysaccharide chains. We found that unstapled peptides showed similar binding affinities for bacterial EVs regardless of surface polysaccharide chains, whereas stapled peptides showed substantially decreased binding affinities for bacterial EVs covered with capsular polysaccharides. This is probably because curvature-sensing peptides must pass through the layer of hydrophilic polysaccharide chains prior to binding to the hydrophobic membrane surface. While stapled peptides with restricted structures cannot easily pass through the layer of polysaccharide chains, unstapled peptides with flexible structures can easily approach the membrane surface. Therefore, we concluded that the structural flexibility of curvature-sensing peptides is a key factor for governing the highly sensitive detection of bacterial EVs.

Published
2023

27. Effect of Obesity on Masticatory Muscle Activity and Rhythmic Jaw Movements Evoked by Electrical Stimulation of Different Cortical Masticatory Areas.

Author

Li, Ruixin, Kato, Chiho, Fujita, Akiyo, Abe, Yasunori, Ogawa, Takuya, Ishidori, Hideyuki, Misawa, Eri, Okihara, Hidemasa, Kokai, Satoshi, and Ono, Takashi

Subjects
ELECTRIC stimulation, MASTICATORY muscles, MASSETER muscle, LABORATORY rats, JAWS, OBESITY
Abstract

This study investigates rhythmic jaw movement (RJM) patterns and masticatory muscle activities during electrical stimulation in two cortical masticatory areas in obese male Zucker rats (OZRs), compared to their counterparts—lean male Zucker rats (LZRs) (seven each). At the age of 10 weeks, electromyographic (EMG) activity of the right anterior digastric muscle (RAD) and masseter muscles, and RJMs were recorded during repetitive intracortical micro-stimulation in the left anterior and posterior parts of the cortical masticatory area (A-area and P-area, respectively). Only P-area-elicited RJMs, which showed a more lateral shift and slower jaw-opening pattern than A-area-elicited RJMs, were affected by obesity. During P-area stimulation, the jaw-opening duration was significantly shorter (p < 0.01) in OZRs (24.3 ms) than LZRs (27.9 ms), the jaw-opening speed was significantly faster (p < 0.05) in OZRs (67.5 mm/s) than LZRs (50.8 mm/s), and the RAD EMG duration was significantly shorter (p < 0.01) in OZRs (5.2 ms) than LZR (6.9 ms). The two groups had no significant difference in the EMG peak-to-peak amplitude and EMG frequency parameters. This study shows that obesity affects the coordinated movement of masticatory components during cortical stimulation. While other factors may be involved, functional change in digastric muscle is partly involved in the mechanism. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Association between Smoking during Pregnancy and Short Root Anomaly in Offspring

Author

Sagawa, Yuki, primary, Ogawa, Takuya, additional, Matsuyama, Yusuke, additional, Nakagawa Kang, Junka, additional, Yoshizawa Araki, Miyu, additional, Unnai Yasuda, Yuko, additional, Tumurkhuu, Tsasan, additional, Ganburged, Ganjargal, additional, Bazar, Amarsaikhan, additional, Tanaka, Toshihiro, additional, Fujiwara, Takeo, additional, and Moriyama, Keiji, additional

Published
2021
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45. Additional file 1: of Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients

Author

Funahashi, Kenta, Shiba, Takahiko, Watanabe, Takayasu, Muramoto, Keiko, Takeuchi, Yasuo, Ogawa, Takuya, Izumi, Yuichi, Sekizaki, Tsutomu, Nakagawa, Ichiro, and Moriyama, Keiji

Abstract

Figure S1. Number of OTUs, Shannonâ s diversity index, and rarefaction curves. Figure S2. PCoA plots with information of appliances. Figure S3. Scatter graphs of mRNA abundances for pairs of interacting core taxa. Figure S4. PCoA plots for the functional profiles assigned using BLASTX. Table S1. Summary of Illumina MiSeq reads and the derived data. Table S2. Rank distribution of species assigned for the rc-rRNA OTUs (relative abundance per participant). Table S3. Rank distribution of the level-1 SEED subsystem functions assigned for the mRNA reads (relative abundance per participant). Table S4. Rank distribution of the level-2 KEGG functions assigned for the mRNA reads (relative abundance per participant). Table S5. Rank distribution of the top 50 species assigned for the mRNA reads (relative abundance per participant). Table S6. Rank distribution of VTiF (mean RPKM values among the participants and the mRNA-to-rRNA ratio). Table S7. Rank distribution of the top 50 VFDB functions assigned for the mRNA reads (relative abundance per participant). Table S8. Rank distribution of the top 50 MvirDB functions assigned for the mRNA reads (relative abundance per participant). (PDF 454 kb)

Published
2019
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