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2. The ratio of brain natriuretic peptide level and computed tomography pulmonary angiography parameters in pulmonary embolism in relation to sex.

Author

BOSKOVIC SEKULIC, Jelena, SEKULIC, Igor, DZUDOVIC, Boris, SUBOTIC, Bojana, JOVANOVIC, Ljiljana, SALINGER, Sonja, MATIJASEVIC, Jovan, KOVACEVIC, Tamara, MITEVSKA, Irena, MILORADOVIC, Vladimir, NESKOVIC, Aleksandar, and OBRADOVIC, Slobodan

Abstract

OBJECTIVES: The objective of this study was to investigate whether there are differences between brain natriuretic peptide (BNP) levels and computed tomography pulmonary angiography (CTPA) parameters, in patients with acute PE, with respect of sex. BACKGROUND: Acute pulmonary embolism (PE) may provoke sudden right ventricle overload and stretching of their thin walls, causing significant raise of BNP blood levels, which correlates to acute PE severity. The properties of RV are different between sexes. METHODS: This retrospective analysis was gained from the data of 1612 PE patients from the regional PE register. The patients have had CTPA verification of PE, with described localization of thrombus masses, as well as the ratio between RV and left ventricle (RV/LV), and BNP as biomarker, measured during the first 24 hours upon admission. RESULTS: Out of 96 male patients with detected central thrombus, 75.0% patients had an increase in BNP level compared to 25.0% patients with normal BNP value (p<0.001). Of the 94 female patients with central thrombus, 85.1% patients had an elevated BNP level, compared to 14.9% patients, with BNP normal values (p<0.001). Of the 135 male patients with RV/LV>1, 79.3% of them, had elevated BNP, compared to 20.7% patients whose BNP level was normal (p<0.001). Out of 123 female patients with RV/LV>1, 91.1% patients had elevated BNP compared to 8.9%, whose BNP was normal (p<0.001). CONCLUSION: Elevated BNP blood level correlates with CTPA parameters, such as the presence of central thrombus and the ratio between right and left ventricles greater than 1, in patients with acute PE, regardless of sex [ABSTRACT FROM AUTHOR]

Published
2024

3. Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Author

Bartunek, Jozef, Terzic, Andre, Davison, Beth A, Filippatos, Gerasimos S, Radovanovic, Slavica, Beleslin, Branko, Merkely, Bela, Musialek, Piotr, Wojakowski, Wojciech, Andreka, Peter, Horvath, Ivan G, Katz, Amos, Dolatabadi, Dariouch, El Nakadi, Badih, Arandjelovic, Aleksandra, Edes, Istvan, Seferovic, Petar M, Obradovic, Slobodan, Vanderheyden, Marc, Jagic, Nikola, Petrov, Ivo, Atar, Shaul, Halabi, Majdi, Gelev, Valeri L, Shochat, Michael K, Kasprzak, Jaroslaw D, Sanz-Ruiz, Ricardo, Heyndrickx, Guy R, Nyolczas, Noémi, Legrand, Victor, Guédès, Antoine, Heyse, Alex, Moccetti, Tiziano, Fernandez-Aviles, Francisco, Jimenez-Quevedo, Pilar, Bayes-Genis, Antoni, Hernandez-Garcia, Jose Maria, Ribichini, Flavio, Gruchala, Marcin, Waldman, Scott A, Teerlink, John R, Gersh, Bernard J, Povsic, Thomas J, Henry, Timothy D, Metra, Marco, Hajjar, Roger J, Tendera, Michal, Behfar, Atta, Alexandre, Bertrand, Seron, Aymeric, Stough, Wendy Gattis, Sherman, Warren, Cotter, Gad, and Wijns, William

Subjects
Heart Disease, Clinical Research, Clinical Trials and Supportive Activities, Cardiovascular, Stem Cell Research, Adult, Aged, Double-Blind Method, Female, Heart Failure, Humans, Male, Mesenchymal Stem Cell Transplantation, Middle Aged, Myocardial Ischemia, Prospective Studies, Treatment Outcome, Young Adult, Regenerative medicine, Cardiopoiesis, Cardiovascular disease, Stem cell, Target population, Disease severity, Marker, Precision medicine, CHART Program, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
Abstract

AimsCardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort.Methods and resultsThis multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. Those achieving > 24 million mesenchymal stem cells (n = 315) were randomized to cardiopoietic cells delivered endomyocardially with a retention-enhanced catheter (n = 157) or sham procedure (n = 158). Procedures were performed as randomized in 271 patients (n = 120 cardiopoietic cells, n = 151 sham). The primary efficacy endpoint was a Finkelstein-Schoenfeld hierarchical composite (all-cause mortality, worsening heart failure, Minnesota Living with Heart Failure Questionnaire score, 6-min walk distance, left ventricular end-systolic volume, and ejection fraction) at 39 weeks. The primary outcome was neutral (Mann-Whitney estimator 0.54, 95% confidence interval [CI] 0.47-0.61 [value > 0.5 favours cell treatment], P = 0.27). Exploratory analyses suggested a benefit of cell treatment on the primary composite in patients with baseline left ventricular end-diastolic volume 200-370 mL (60% of patients) (Mann-Whitney estimator 0.61, 95% CI 0.52-0.70, P = 0.015). No difference was observed in serious adverse events. One (0.9%) cardiopoietic cell patient and 9 (5.4%) sham patients experienced aborted or sudden cardiac death.ConclusionThe primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.

Published
2017

4. The significance of early-onset malignant arrhythmias in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention and their relationship with biomarkers

Author

Romanovic, Radoslav, primary, Dzudovic, Boris, additional, Djenic, Nemanja, additional, Jovic, Zoran, additional, Spasic, Marjan, additional, Djuric, Obrad, additional, Hladis, Andjelko, additional, Malovic, Dragana, additional, and Obradovic, Slobodan, additional

Published
2024
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5. Authorship: From credit to accountability. Reflections from the Editors’ Network

Author

Alfonso, Fernando, Zelveian, Parounak, Monsuez, Jean-Jacques, Aschermann, Michael, Boehm, Michael, Hernandez, Alfonso Buendia, Wang, Tzung-Dau, Cohen, Ariel, Izetbegovic, Sebija, Doubell, Anton, Echeverri, Dario, Enç, Nuray, Ferreira-González, Ignacio, Undas, Anetta, Fortmüller, Ulrike, Gatzov, Plamen, Ginghina, Carmen, Goncalves, Lino, Addad, Faouzi, Hassanein, Mahmoud, Heusch, Gerd, Huber, Kurt, Hatala, Robert, Ivanusa, Mario, Lau, Chu-Pak, Marinskis, Germanas, Cas, Livio Dei, Rochitte, Carlos Eduardo, Nikus, Kjell, Fleck, Eckart, Pierard, Luc, Obradović, Slobodan, Passano, María del Pilar Aguilar, Jang, Yangsoo, Rødevand, Olaf, Sander, Mikael, Shlyakhto, Evgeny, Erol, Çetin, Tousoulis, Dimitris, Ural, Dilek, Piek, Jan J., Varga, Albert, Flammer, Andreas J., Mach, François, Dibra, Alban, Guliyev, Faiq, Mrochek, Alexander, Rogava, Mamanti, Melgar, Ismael Guzman, Di Pasquale, Giuseppe, Kabdrakhmanov, Kanat, Haddour, Laila, Fras, Zlatko, Held, Claes, and Shumakov, Valentyn

Published
2019
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6. Initial results of investigator initiated international database on catheter directed therapy of acute pulmonary embolism.

Author

Jermakow, Mateusz T., Obradovic, Slobodan, Salinas, Pablo, Roik, Marek, Dzudovic, Boris, Sekulic, Igor, Macaya, Fernando, Paredes-Vazquez, Jose, Velázquez Martín, Maite, Maneir oMelón, Nicolás Manuel, Nedeljkov, Djordje, Matijasevic, Jovan, Łabyk1, Andrzej, Krakowian, Marcin, Stępniewski, Jakub, Araszkiewicz, Aleksander, and Pruszczyk, Piotr

Published
2024
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7. Association of Blood Leukocytes and Hemoglobin with Hospital Mortality in Acute Pulmonary Embolism

Author

Obradovic, Slobodan, primary, Dzudovic, Boris, additional, Subotic, Bojana, additional, Salinger, Sonja, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Kovacevic, Tamara, additional, Kovacevic-Kuzmanovic, Ana, additional, Mitevska, Irena, additional, Miloradovic, Vladimir, additional, Jevtic, Ema, additional, and Neskovic, Aleksandar, additional

Published
2023
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8. Initial results of investigator initiated international database on catheter directed therapy of acute pulmonary embolism

Author

Jermakow, Mateusz T., primary, Obradovic, Slobodan, additional, Salinas, Pablo, additional, Roik, Marek, additional, Dzudovic, Boris, additional, Sekulic, Igor, additional, Macaya, Fernando, additional, Paredes-Vazquez, Jose, additional, Velázquez Martín, Maite, additional, Maneiro Melón, Nicolás Manuel, additional, Nedeljkov, Djordje, additional, Matijasevic, Jovan, additional, Łabyk, Andrzej, additional, Krakowian, Marcin, additional, Stępniewski, Jakub, additional, Araszkiewicz, Aleksander, additional, and Pruszczyk, Piotr, additional

Published
2023
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9. New-Onset Paroxysmal Atrial Fibrillation in the Setting of Acute Pulmonary Embolism Is Associated with All-Cause Hospital Mortality in Women but Not in Men

Author

Djuric, Ivica, primary, Dzudovic, Boris, additional, Subotic, Bojana, additional, Dzudovic, Jelena, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Salinger, Sonja, additional, Mitevska, Irena, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Simovic, Stefan, additional, Miloradovic, Vladimir, additional, Savicic, Tanja, additional, Bozovic, Bjanka, additional, Bulatovic, Nebojsa, additional, Kafedzic, Srdjan, additional, Neskovic, Aleksandar N., additional, Kocev, Nikola, additional, Marinković, Jelena, additional, and Obradovic, Slobodan, additional

Published
2023
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10. Signs and symptoms of acute pulmonary embolism and their predictive value for all-cause hospital death in respect of severity of the disease, age, sex and body mass index: retrospective analysis of the Regional PE Registry (REPER)

Author

Ružičić, Dušan Predrag, primary, Dzudovic, Boris, additional, Matijasevic, Jovan, additional, Benic, Marija, additional, Salinger, Sonja, additional, Kos, Ljiljana, additional, Kovacevic-Preradovic, Tamara, additional, Mitevska, Irena, additional, Neskovic, Aleksandar, additional, Bozovic, Bjanka, additional, Bulatovic, Nebojsa, additional, Miloradovic, Vladimir, additional, Djuric, Ivica, additional, and Obradovic, Slobodan, additional

Published
2023
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11. Acute coronary syndrome in a young patient with ECG presentation of acute inferior myocardial infarction and acute thrombosis of left main stem coronary artery

Author

Djenic, Nemanja, primary, Milovanovic, Branko, additional, Romanovic, Radoslav, additional, Stojkovic, Sinisa, additional, Hladis, Andjelko, additional, Spasic, Marijan, additional, Dzudovic, Boris, additional, Dulovic, Dragan, additional, Jovic, Zoran, additional, and Obradovic, Slobodan, additional

Published
2023
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12. Apert Syndrome with Agenesis of the Corpus Collosum - Case Report

Author

Nestorovic-Tanaskovic, Jelena, primary, Igrutinovic, Zoran, additional, Vuletic, Biljana, additional, Radovanovic, Маrija, additional, Dabovic, Jovana, additional, Savic, Dragana, additional, Medovic, Raša, additional, Raskovic, Zorica, additional, Knezevic-Rangelov, Sanja, additional, and Obradovic, Slobodan, additional

Published
2022
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13. Prognostic Value of D-Dimer in Younger Patients with Pulmonary Embolism

Author

Jovanovic, Ljiljana, Subota, Vesna, Rajkovic, Milena, Subotic, Bojana, Dzudovic, Boris, Novcic, Natasa, Matijasevic, Jovan, Miric, Milica, Salinger, Sonja, Nikolic, Natasa Markovic, Nikolic, Maja, Miloradovic, Vladimir, Kos, Ljiljana, Kovacevic-Preradovic, Tamara, and Obradovic, Slobodan

Abstract

In patients with pulmonary embolism (PE), the D-dimer assay is commonly utilized as part of the diagnostic workup, but data on D-dimer for early risk stratification and short-term mortality prediction are limited. The purpose of this study was to determine D-dimer levels as a predictive biomarker of PE outcomes in younger (<50 years of age) compared to older patients. We conducted retrospective analysis for 930 patients diagnosed with PE between 2015 and 2019 as part of the Serbian University Multicenter Pulmonary Embolism Registry (SUPER).All patients had D-dimer levels measured within 24 hours of hospital admission. The primary outcome was mortality at 30 days or during hospitalization. Patients were categorized into two groups based on age (≤ 50 and >50 years of age). Younger patients constituted 20.5% of the study cohort. Regarding all-cause mortality, 5.2% (10/191)of patients died in group under the 50 years of age; the short-term all-causemortality was 12.4% (92/739) in older group.We have found that there was significant difference in plasma D-dimer level between patients ≤ 50 years of age and older group (>50), p= 0.006.D-dimer plasma level had good predictive value for the primary outcome in younger patients (c-statistics 0.710; 95% CI, 0.640-0.773; p<0.031). The optimal cutoff level for D-dimer to predict PE-cause death in patients aged > 50 years was found to be 8.8 mg/l FEU(c-statistics 0,580; 95% CI 0.544-0.616; p=0.049). In younger PE patients, D-dimer levels have good prognostic performance for 30-day all-cause mortalityand concentrations above 6.3 mg/l FEU are associated with increased risk of death. D-dimer in patients aged over 50 years does not have predictive ability for all-caused short-term mortality. The relationship between D-dimer and age in patients with PE may need further evaluation.

Published
2023
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15. A Rare Case of Undifferentiated Pleomorphic Sarcoma with Central Necrosis in the Right Atrium.

Author

Mladenovic, Zorica, Obradovic, Slobodan, Ristic, Sasa, Djenic, Ljubinko, and Begic, Edin

Abstract

Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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16. Predictive value of heart failure with reduced versus preserved ejection fraction for outcome in pulmonary embolism

Author

Gluvic Zoran, Dzudovic Boris, Kafedzic Srdjan, Mladenovic Zorica, Nikolic Maja, Zec Nenad, Neskovic Aleksandar, Pekovic Sandra, Matijasevic Jovan, Obradovic Slobodan, Subotic Bojana, Kovacevic-Kuzmanovic Ana, Srdanovic Ilija, Jovanovic Ljiljana, Salinger-Martinovic Sonja, Miloradovic Vladimir, Markovic-Nikolic Natasa, Bokan Aleksandar, Pancevacki Sasa, Kovacevic-Preradovic Tamara, Konstantinides Stavros, Trobok Jadranka, and Kos Ljiljana

Subjects
Ejection fraction, medicine.medical_specialty, Heart failure, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Original Research Articles, Internal medicine, Diseases of the circulatory (Cardiovascular) system, Medicine, Original Research Article, 030212 general & internal medicine, Mortality, Risk factor, business.industry, Pulmonary embolism, Hazard ratio, Atrial fibrillation, medicine.disease, 3. Good health, Blood pressure, RC666-701, Cardiology, Cardiology and Cardiovascular Medicine, business, Heart failure with preserved ejection fraction
Abstract

Aims This study aimed to investigate whether the risk of short‐term mortality is different in pulmonary embolism (PE) patients who have heart failure with reduced ejection fraction (HFrEF) as compared with those with heart failure with preserved ejection fraction (HFpEF). Methods and results Predictive value of HFrEF or HFpEF for 7‐day (intrahospital) and 30‐day all‐cause mortality was determined in the cohort of 1055 out of 1201 consecutive acute PE patients from the Serbian multicentre PE registry. Patients were classified into either HFrEF or HFpEF group, according to guideline‐proposed criteria. A 7‐day (intrahospital) and 30‐day all‐cause mortality was 18.5% vs. 7.3% vs. 4.5% (P

Published
2020

20. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS) : The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)

Author

Konstantinides, Stavros V., Meyer, Guy, Bueno, Hector, Galié, Nazzareno, Gibbs, J. Simon R., Ageno, Walter, Agewall, Stefan, Almeida, Ana G., Andreotti, Felicita, Barbato, Emanuele, Baumbach, Andreas, Beygui, Farzin, Carlsen, Jørn, De Carlo, Marco, Delcroix, Marion, Subias, Pilar Escribano, Gaine, Sean, Goldhaber, Samuel Z., Gopalan, Deepa, Habib, Gilbert, Jenkins, David, Kjellström, Barbro, Lainscak, Mitja, Lee, Geraldine, Le Gal, Grégoire, Messas, Emmanuel, Morais, Joao, Piepoli, Massimo Francesco, Price, Susanna, Salvi, Aldo, Sanchez, Olivier, Stortecky, Stefan, Thielmann, Matthias, Noordegraaf, Anton Vonk, Becattini, Cecilia, Bueno, Héctor, Geersing, Geert Jan, Harjola, Veli Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jiménez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Áinle, Fionnuala Ní, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Zamorano, José Luis, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen E., Petronio, Anna Sonia, Richter, Dimitrios J., Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Hammoudi, Naima, Hayrapetyan, Hamlet, Mascherbauer, Julia, Ibrahimov, Firdovsi, Polonetsky, Oleg, Lancellotti, Patrizio, Tokmakova, Mariya, Skoric, Bosko, Michaloliakos, Ioannis, Hutyra, Martin, Mellemkjaer, Søren, Mansour, Mostafa, Reinmets, Julia, Jääskeläinen, Pertti, Angoulvant, Denis, Bauersachs, Johann, Giannakoulas, George, Zima, Endre, Vizza, Carmine Dario, Sugraliyev, Akhmetzhan, Bytyçi, Ibadete, Maca, Aija, Ereminiene, Egle, Huijnen, Steve, Xuereb, Robert, Diaconu, Nadejda, Bulatovic, Nebojsa, Asfalou, Ilyasse, Bosevski, Marijan, Halvorsen, Sigrun, Sobkowicz, Bozena, Ferreira, Daniel, Petris, Antoniu Octavian, Moiseeva, Olga, Zavatta, Marco, Obradovic, Slobodan, Šimkova, Iveta, Radsel, Peter, Ibanez, Borja, Wikström, Gerhard, Aujesky, Drahomir, Kaymaz, Cihangir, Parkhomenko, Alexander, and Pepke-Zaba, Joanna

Subjects
thrombolysis, pulmonary embolism, treatment, diagnosis, education, venous thromboembolism, biomarkers, heart failure, shock, Embolectomy, Guidelines, dyspnoea, right ventricle, humanities, Anticoagulation, Pregnancy, Venous thrombosis, Journal Article, echocardiography, Cardiology and Cardiovascular Medicine, health care economics and organizations, Risk assessment
Abstract

Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate.

Published
2020

21. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European respiratory society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)

Author

HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cancer, Global Health, Cardiovasculaire Epi Team 9, Konstantinides, Stavros V., Meyer, Guy, Bueno, Hector, Galié, Nazzareno, Gibbs, J. Simon R., Ageno, Walter, Agewall, Stefan, Almeida, Ana G., Andreotti, Felicita, Barbato, Emanuele, Baumbach, Andreas, Beygui, Farzin, Carlsen, Jørn, De Carlo, Marco, Delcroix, Marion, Subias, Pilar Escribano, Gaine, Sean, Goldhaber, Samuel Z., Gopalan, Deepa, Habib, Gilbert, Jenkins, David, Kjellström, Barbro, Lainscak, Mitja, Lee, Geraldine, Le Gal, Grégoire, Messas, Emmanuel, Morais, Joao, Piepoli, Massimo Francesco, Price, Susanna, Salvi, Aldo, Sanchez, Olivier, Stortecky, Stefan, Thielmann, Matthias, Noordegraaf, Anton Vonk, Becattini, Cecilia, Bueno, Héctor, Geersing, Geert Jan, Harjola, Veli Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jiménez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Áinle, Fionnuala Ní, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Zamorano, José Luis, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen E., Petronio, Anna Sonia, Richter, Dimitrios J., Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Hammoudi, Naima, Hayrapetyan, Hamlet, Mascherbauer, Julia, Ibrahimov, Firdovsi, Polonetsky, Oleg, Lancellotti, Patrizio, Tokmakova, Mariya, Skoric, Bosko, Michaloliakos, Ioannis, Hutyra, Martin, Mellemkjaer, Søren, Mansour, Mostafa, Reinmets, Julia, Jääskeläinen, Pertti, Angoulvant, Denis, Bauersachs, Johann, Giannakoulas, George, Zima, Endre, Vizza, Carmine Dario, Sugraliyev, Akhmetzhan, Bytyçi, Ibadete, Maca, Aija, Ereminiene, Egle, Huijnen, Steve, Xuereb, Robert, Diaconu, Nadejda, Bulatovic, Nebojsa, Asfalou, Ilyasse, Bosevski, Marijan, Halvorsen, Sigrun, Sobkowicz, Bozena, Ferreira, Daniel, Petris, Antoniu Octavian, Moiseeva, Olga, Zavatta, Marco, Obradovic, Slobodan, Šimkova, Iveta, Radsel, Peter, Ibanez, Borja, Wikström, Gerhard, Aujesky, Drahomir, Kaymaz, Cihangir, Parkhomenko, Alexander, Pepke-Zaba, Joanna, HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cancer, Global Health, Cardiovasculaire Epi Team 9, Konstantinides, Stavros V., Meyer, Guy, Bueno, Hector, Galié, Nazzareno, Gibbs, J. Simon R., Ageno, Walter, Agewall, Stefan, Almeida, Ana G., Andreotti, Felicita, Barbato, Emanuele, Baumbach, Andreas, Beygui, Farzin, Carlsen, Jørn, De Carlo, Marco, Delcroix, Marion, Subias, Pilar Escribano, Gaine, Sean, Goldhaber, Samuel Z., Gopalan, Deepa, Habib, Gilbert, Jenkins, David, Kjellström, Barbro, Lainscak, Mitja, Lee, Geraldine, Le Gal, Grégoire, Messas, Emmanuel, Morais, Joao, Piepoli, Massimo Francesco, Price, Susanna, Salvi, Aldo, Sanchez, Olivier, Stortecky, Stefan, Thielmann, Matthias, Noordegraaf, Anton Vonk, Becattini, Cecilia, Bueno, Héctor, Geersing, Geert Jan, Harjola, Veli Pekka, Huisman, Menno V., Humbert, Marc, Jennings, Catriona Sian, Jiménez, David, Kucher, Nils, Lang, Irene Marthe, Lankeit, Mareike, Lorusso, Roberto, Mazzolai, Lucia, Meneveau, Nicolas, Áinle, Fionnuala Ní, Prandoni, Paolo, Pruszczyk, Piotr, Righini, Marc, Torbicki, Adam, Van Belle, Eric, Zamorano, José Luis, Windecker, Stephan, Aboyans, Victor, Baigent, Colin, Collet, Jean Philippe, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gale, Chris P., Grobbee, Diederick E., Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Landmesser, Ulf, Leclercq, Christophe, Lettino, Maddalena, Lewis, Basil S., Merkely, Bela, Mueller, Christian, Petersen, Steffen E., Petronio, Anna Sonia, Richter, Dimitrios J., Roffi, Marco, Shlyakhto, Evgeny, Simpson, Iain A., Sousa-Uva, Miguel, Touyz, Rhian M., Hammoudi, Naima, Hayrapetyan, Hamlet, Mascherbauer, Julia, Ibrahimov, Firdovsi, Polonetsky, Oleg, Lancellotti, Patrizio, Tokmakova, Mariya, Skoric, Bosko, Michaloliakos, Ioannis, Hutyra, Martin, Mellemkjaer, Søren, Mansour, Mostafa, Reinmets, Julia, Jääskeläinen, Pertti, Angoulvant, Denis, Bauersachs, Johann, Giannakoulas, George, Zima, Endre, Vizza, Carmine Dario, Sugraliyev, Akhmetzhan, Bytyçi, Ibadete, Maca, Aija, Ereminiene, Egle, Huijnen, Steve, Xuereb, Robert, Diaconu, Nadejda, Bulatovic, Nebojsa, Asfalou, Ilyasse, Bosevski, Marijan, Halvorsen, Sigrun, Sobkowicz, Bozena, Ferreira, Daniel, Petris, Antoniu Octavian, Moiseeva, Olga, Zavatta, Marco, Obradovic, Slobodan, Šimkova, Iveta, Radsel, Peter, Ibanez, Borja, Wikström, Gerhard, Aujesky, Drahomir, Kaymaz, Cihangir, Parkhomenko, Alexander, and Pepke-Zaba, Joanna

Published
2020

22. Different predictive value for short-term all-cause mortality with commonly used biomarkers regarding the cause of pulmonary embolism

Author

Jovanovic, Ljiljana, primary, Subota, Vesna, additional, Stavric, Milena, additional, Dzudovic, Boris, additional, Subotic, Bojana, additional, Novcic, Natasa, additional, Miric, Milica, additional, Matijasevic, Jovan, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Salinger, Sonja, additional, Markovic-Nikolic, Natasa, additional, Kos, Ljiljana, additional, Preradovic-Kovacevic, Tamara, additional, and Obradovic, Slobodan, additional

Published
2021
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23. Organization of basic education in transthoracic echocardiography in Serbia: A viewpoint of the Echocardiographic Society of Serbia

Author

Stankovic, Ivan, primary, Mladenovic, Zorica, additional, Trifunovic-Zamaklar, Danijela, additional, Vujisic-Tesic, Bosiljka, additional, Jovovic, Ljiljana, additional, Dekleva-Manojlovic, Milica, additional, Stojsic-Milosavljevic, Anastazija, additional, Deljanin-Ilic, Marina, additional, Kalimanovska-Ostric, Dimitra, additional, Obradovic, Slobodan, additional, and Neskovic, Aleksandar, additional

Published
2021
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24. Predictive value of heart failure with reduced versus preserved ejection fraction for outcome in pulmonary embolism

Author

Obradovic, Slobodan, primary, Dzudovic, Boris, additional, Subotic, Bojana, additional, Matijasevic, Jovan, additional, Mladenovic, Zorica, additional, Bokan, Aleksandar, additional, Trobok, Jadranka, additional, Pekovic, Sandra, additional, Salinger‐Martinovic, Sonja, additional, Jovanovic, Ljiljana, additional, Kos, Ljiljana, additional, Kovacevic‐Preradovic, Tamara, additional, Nikolic, Maja, additional, Miloradovic, Vladimir, additional, Kovacevic‐Kuzmanovic, Ana, additional, Zec, Nenad, additional, Markovic‐Nikolic, Natasa, additional, Srdanovic, Ilija, additional, Gluvic, Zoran, additional, Kafedzic, Srdjan, additional, Pancevacki, Sasa, additional, Neskovic, Aleksandar, additional, and Konstantinides, Stavros, additional

Published
2020
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25. Association of PC and AT levels in the early phase of STEMI treated with pPCI with LV systolic function and 6-month MACE

Author

Obradovic, Slobodan, primary, Begic, Edin, additional, Jankovic, Slobodan, additional, Romanovic, Radoslav, additional, Djenic, Nemanja, additional, Dzudovic, Boris, additional, Jovic, Zoran, additional, Malovic, Dragana, additional, Subota, Vesna, additional, Stavric, Milena, additional, Ljuca, Farid, additional, and Kusljugic, Zumreta, additional

Published
2020
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30. P4637Elevated von Willebrand factor (VWF) and factor VIII are associated with higher clinical SYNTAX score in patients with stable coronary artery disease

Author

Z J Jovic Zoran, M S Spasic Marijan, P D J Prokic Djordje, P Djuric, Z R Radojicic Zoran, Z M Mladenovic Zorica, J M Maric Kocijancic Jelena, and S O Obradovic Slobodan

Subjects
medicine.medical_specialty, Endothelium, biology, business.industry, Coronary arteriosclerosis, medicine.disease, Syntax, Coronary artery disease, medicine.anatomical_structure, Von Willebrand factor, Internal medicine, medicine, Cardiology, biology.protein, In patient, Cardiology and Cardiovascular Medicine, business
Abstract

Background Von Willebrand factor (VWF plays) central role in thrombogenesis, and circulates in a noncovalent complex with factor VIII (FVIII), acting as a transporter protein and stabilizer. VW factor protects FVIII from proteolytic inactivation and concentrate it at site of endothelial injury. Raised plasma VWF factor is detected in case of endothelial damage and it has been considered as a useful marker of endothelial dysfunction. Increased plasma FVIII has been found in venous thromboembolism and in some clinical conditions associated with chronic inflammation. The connection between FVIII and more incidence of arterial thrombosis is, partly, due to increased platelet adhesion/aggregation, induced by VWF at sites of arterial wall damage. The correlation between VWF factor, FVIII levels and acute coronary syndrome is well documented, but there are no available dates regarding relation between plasma levels of VW factor, FVIII and the severity of coronary artery disease according to SYNTAX I (SS) and Clinical SYNTAX score (CSS). Purpose The aim of this study was to determine the association between levels of VW factor and FVIII and the severity of coronary artery disease according to SS and CSS. Methods A total of 82 patients with symptoms of stable angina underwent coronary angiography and were divided into three groups according to SS and CSS: Group I (33). We calculated Clinical SYNTAX multiplying the value of SYNTAX score with the modified ACEF score, based on the patients' left ventricular ejection fraction, age and creatinine clearance derived using the Cockcroft–Gault equation. Results There were positive association between plasma levels of VW factor and severity of CAD according to SYNTAX I (Group I: 1.16±0.59, Group II: 1.52±0.62, Group III 1.49±0.80, Kruskal Wallis p=0.040) and Clinical SYNTAX score (Group I: 1.15±0.53, Group II: 1.38±0.72, Group III 1.57±0.75, Kruskal Wallis p=0.034). VW factor levels were significantly higher in Group II and Group III compared to Group I (SS: Mann- Whitney p=0.023 and 0.071, respectively), (CSS: p=0.251 and 0.009, respectively). We also found positive association between FVIII levels and severity of CAD according to SYNTAX I (Group I: 2.25±0.75, Group II: 2.21±0.53, Group III 2.97±0.95, Kruskal Wallis p=0.007) and Clinical SYNTAX score (Group I: 2.17±0.71, Group II: 2.26±0.68, Group III 2.89±0.87, Kruskal Wallis p=0.002). This study demonstrates that FVIII levels were significantly higher in Group III compared to Group I and Group II (SS: Mann- Whitney p=0.005 and 0.005, respectively), (CSS: p=0.001 and 0.014, respectively). The correlation between plasma levels of VW factor Conclusion Patients with stable angina pectoris and higher levels of VW and factor VIII had a higher Clinical SYNTAX and SYNTAX I score. Our study revealed that concomitant elevation in both VW and FVIII factors are a significant risk factor and predictor of more severe and extended CAD.

Published
2019

33. Platelet aggregability and anticoagulant proteins activity during dobutamine stress echocardiography in asymptomatic patients four months after percutaneous coronary intervention

Author

Jovic, Zoran, primary, Subota, Vesna, additional, Dzudovic, Boris, additional, Mladenovic, Zorica, additional, Maric-Kocijancic, Jelena, additional, Djuric, Predrag, additional, Spasic, Marijan, additional, Djenic, Nemanja, additional, Romanovic, Radoslav, additional, Miloradovic, Vladimir, additional, Matunovic, Radomir, additional, and Obradovic, Slobodan, additional

Published
2019
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35. Association of PC and AT levels in the early phase of STEMI treated with pPCI with LV systolic function and 6-month MACE

Author

Obradovic, Slobodan, Begic, Edin, Jankovic, Slobodan, Romanovic, Radoslav, Djenic, Nemanja, Dzudovic, Boris, Jovic, Zoran, Malovic, Dragana, Subota, Vesna, Stavric, Milena, Ljuca, Farid, and Kusljugic, Zumreta

Abstract

ABSTRACTObjectives: To examine a relationship between protein C (PC) and antithrombin III (AT III) activities with ejection fraction of left ventricle (EFLV), in the early phase of acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), and to investigate whether PC and AT III are associated with major adverse cardiovascular events (MACE) within 6 months following from pPCI.Patients and methods: The research had a prospective character and included 357 patients who had, following the diagnosis of the STEMI, undergone pPCI at the Clinic of Cardiology and Emergency Internal Medicine, Military Medical Academy, Belgrade, Serbia, from January 2010 until April 2019.Results: The EFLV positively correlated with PC values (rho = 0.229). There was a statistically significant increase in the PC values between patients with MACE compared with those without MACE at 6 months’ follow-up evaluation (p < 0.0001). Also, significant difference in PC values between patients who died in hospital and those who were alive at 6 months’ follow-up (p < 0.01) was observed. PC values were different across different EFLV groups (p < 0.001), increasing from the 1stto the 4thEFLV quartiles: the median and the interquartile values for the 1st, 2nd, 3rdand 4thquartiles were 1.0400IU/l ± 0.15, 1.1400IU/l ± 0.15, 1.1350IU/l ± 0.16 and 1.2200IU/l ± 0.14, respectively.Conclusion: Increased PC activity in the early phase of STEMI is associated with higher EFLV 5 days after the pPCI as well as with MACE at 6 months after the pPCI.

Published
2021
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36. Increased High Sensitive C-reactive Protein is Associated with Major Adverse Cardiovascular Events after STEMI.

Author

Begic, Edin, Obradovic, Slobodan, Jankovic, Slobodan, Romanovic, Radoslav, Djenic, Nemanja, Dzudovic, Boris, Jovic, Zoran, Malovic, Dragana, Subota, Vesna, Stavric, Milena, Ljuca, Farid, and Kusljugic, Zumreta

Subjects
*C-reactive protein, *CARDIOVASCULAR diseases, *MYOCARDIAL infarction, *LONGITUDINAL method, *MAJOR adverse cardiovascular events
Abstract

Objective: This study aims to investigate whether the high sensitive C-reactive protein (hsCRP) is associated with an ejection fraction of left ventricle (EFLV) in the early phase of ST-elevation myocardial infarction (STEMI), treated with the primary percutaneous intervention (pPCI), and to establish whether there exists a relationship between its values and the presence of major adverse cardiovascular events (MACE) within six months of pPCI. Materials and Methods: In this prospective study, 357 patients who were diagnosed with STEMI and who underwent pPCI within 24 hours of pain onset were included. The following were monitored and recorded: 1) hsCRP values, which were measured between 24 and 48 hours of pPCI, 2) EFLV values, which were measured five days after the pPCI, and 3) MACE, which was established within six months of pPCI. Results: The EFLV values measured five days after the pPCI were significantly lower with increasing hsCRP values (rho=- 0.384, p<0.0001). There was a significant difference in hsCRP values between patients who had MACE and those without it (38.35 [98.10] vs. 12.97 [23.80], p=0.0001). In addition, hsCRP values were significantly increased in patients who died during the first six months after the pPCI compared with patients who survived (115.00 [202.80] vs. 15.84 [31.5], p=0.001). Conclusion: The hsCRP values in patients with STEMI who were treated with the pPCI are related to systolic function in the early phase of STEMI, as well as MACE during the first six months of follow-up. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Association between serum concentration of parathyroid hormone and left ventricle ejection fraction, and markers of heart failure and inflammation in ST elevation myocardial infarction patients treated with primary percutaneous coronary intervention

Author

Vukotic, Snjezana, primary, Ristic, Andjelka, additional, Djenic, Nemanja, additional, Ratkovic, Nenad, additional, Romanovic, Radoslav, additional, Vujanic, Svetlana, additional, and Obradovic, Slobodan, additional

Published
2018
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40. Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial.

Author

UCL - SSS/IREC/CARD-Pôle de recherche cardiovasculaire, UCL - (MGD) Service de cardiologie, Bartunek, Jozef, Terzic, Andre, Davison, Beth A, Filippatos, Gerasimos S, Radovanovic, Slavica, Beleslin, Branko, Merkely, Bela, Musialek, Piotr, Wojakowski, Wojciech, Andreka, Peter, Horvath, Ivan G, Katz, Amos, Dolatabadi, Dariouch, El Nakadi, Badih, Arandjelovic, Aleksandra, Edes, Istvan, Seferovic, Petar M, Obradovic, Slobodan, Vanderheyden, Marc, Jagic, Nikola, Petrov, Ivo, Atar, Shaul, Halabi, Majdi, Gelev, Valeri L, Shochat, Michael K, Kasprzak, Jaroslaw D, Sanz-Ruiz, Ricardo, Heyndrickx, Guy R, Nyolczas, Noémi, Legrand, Victor, Guedes, Antoine, Heyse, Alex, Moccetti, Tiziano, Fernandez-Aviles, Francisco, Jimenez-Quevedo, Pilar, Bayes-Genis, Antoni, Hernandez-Garcia, Jose Maria, Ribichini, Flavio, Gruchala, Marcin, Waldman, Scott A, Teerlink, John R, Gersh, Bernard J, Povsic, Thomas J, Henry, Timothy D, Metra, Marco, Hajjar, Roger J, Tendera, Michal, Behfar, Atta, Alexandre, Bertrand, Seron, Aymeric, Stough, Wendy Gattis, Sherman, Warren, Cotter, Gad, Wijns, William, CHART Program, UCL - SSS/IREC/CARD-Pôle de recherche cardiovasculaire, UCL - (MGD) Service de cardiologie, Bartunek, Jozef, Terzic, Andre, Davison, Beth A, Filippatos, Gerasimos S, Radovanovic, Slavica, Beleslin, Branko, Merkely, Bela, Musialek, Piotr, Wojakowski, Wojciech, Andreka, Peter, Horvath, Ivan G, Katz, Amos, Dolatabadi, Dariouch, El Nakadi, Badih, Arandjelovic, Aleksandra, Edes, Istvan, Seferovic, Petar M, Obradovic, Slobodan, Vanderheyden, Marc, Jagic, Nikola, Petrov, Ivo, Atar, Shaul, Halabi, Majdi, Gelev, Valeri L, Shochat, Michael K, Kasprzak, Jaroslaw D, Sanz-Ruiz, Ricardo, Heyndrickx, Guy R, Nyolczas, Noémi, Legrand, Victor, Guedes, Antoine, Heyse, Alex, Moccetti, Tiziano, Fernandez-Aviles, Francisco, Jimenez-Quevedo, Pilar, Bayes-Genis, Antoni, Hernandez-Garcia, Jose Maria, Ribichini, Flavio, Gruchala, Marcin, Waldman, Scott A, Teerlink, John R, Gersh, Bernard J, Povsic, Thomas J, Henry, Timothy D, Metra, Marco, Hajjar, Roger J, Tendera, Michal, Behfar, Atta, Alexandre, Bertrand, Seron, Aymeric, Stough, Wendy Gattis, Sherman, Warren, Cotter, Gad, Wijns, William, and CHART Program

Abstract

AIMS: Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. METHODS AND RESULTS: This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. Those achieving > 24 million mesenchymal stem cells (n = 315) were randomized to cardiopoietic cells delivered endomyocardially with a retention-enhanced catheter (n = 157) or sham procedure (n = 158). Procedures were performed as randomized in 271 patients (n = 120 cardiopoietic cells, n = 151 sham). The primary efficacy endpoint was a Finkelstein-Schoenfeld hierarchical composite (all-cause mortality, worsening heart failure, Minnesota Living with Heart Failure Questionnaire score, 6-min walk distance, left ventricular end-systolic volume, and ejection fraction) at 39 weeks. The primary outcome was neutral (Mann-Whitney estimator 0.54, 95% confidence interval [CI] 0.47-0.61 [value > 0.5 favours cell treatment], P = 0.27). Exploratory analyses suggested a benefit of cell treatment on the primary composite in patients with baseline left ventricular end-diastolic volume 200-370 mL (60% of patients) (Mann-Whitney estimator 0.61, 95% CI 0.52-0.70, P = 0.015). No difference was observed in serious adverse events. One (0.9%) cardiopoietic cell patient and 9 (5.4%) sham patients experienced aborted or sudden cardiac death. CONCLUSION: The primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.

Published
2017

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