21 results on '"O. Browne"'
Search Results
2. National scientific medical meeting 1995 abstracts
- Author
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S. Norris, C. Collins, J. Hegarty, C. O’Farrelly, J. Carton, L. Madrigal, D. P. O’Donoghue, H. Holloway, J. F. Fielding, W. Mullins, S. W. Hone, M. Donnelly, F. Powell, A. W. Blayney, E. A. Cahill, S. F. Daly, M. J. Turner, P. A. Sullivan, M. McLoughlin, M. M. Skelly, H. E. Mulcahy, T. Connell, C. Duggan, M. J. Duffy, A. Troy, K. Sheahan, A. Whelan, C. M. Herra, C. T. Keane, H. Johnson, B. Lee, E. Doherty, T. McDonnell, D. Mulherin, O. FitzGerald, B. Bresnihan, H. M. Hassett, A. Boyce, V. Greig, C. O’Herlihy, P. P. A. Smyth, E. F. Roche, I. McCormack, E. Tempany, M. J. Cullen, D. F. Smith, Y. McBrinn, B. Murray, R. Freaney, D. Keating, M. J. McKenna, J. A. O’Hare, H. Alam, Q. Raza, M. Geoghegan, S. Killalea, M. Hall, J. Feely, L. Kyne, B. O’Hara, M. Cullen, I. M. Rea, J. P. Donnelly, R. W. Stout, P. Lacey, M. J. Donnelly, J. McGrath, T. P. Hennessy, C. V. I. Timon, D. Hyde, H. X. Xia, M. Buckley, C. O’Morain, S. Keating, H. Xia, J. P. McGrath, R. C. Stuart, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, M. Duffy, M. Tubridy, J. Redmond, K. Monahan, R. P. Murphy, D. R. Headon, T. O’Gorman, F. M. O’Reilly, C. Darby, G. M. Murphy, A. Murphy, M. Codd, P. Dervan, D. Lawlor, S. O. Loughlin, N. Flanagan, R. Watson, L. Barnes, C. Kilgallen, E. Sweeney, A. Mynes, D. Mooney, I. Donoghue, O. Browne, J. A. Kirrane, D. McKenna, M. Young, E. O’Toole, S. O’Briain, U. Srinivasan, C. Feighery, N. Leonard, E. Jones, M. A. Moloney, D. G. Weir, M. Lawler, A. O’Neill, H. Gowing, D. Pamphilon, S. R. McCann, G. O’Toole, A. Orren, C. M. Seifer, D. C. Crowley, G. J. Sheehan, T. Deignan, J. Kelly, V. J. Tormey, J. Faul, C. Leonard, C. M. Burke, L. W. Poulter, S. Lynch, G. McEntee, O. Traynor, E. Barry, P. Costello, A. Keavney, R. Willoughby, C. O’Donnell, M. Cahill, A. Earley, P. Eustace, R. Osborne, C. Saidlear, B. Holmes, A. Early, A. P. Moran, A. Neisser, R. J. Polt, H. Bernheimer, M. Kainz, B. Schwerer, L. Gallagher, R. Firth, N. Kennedy, E. McGilloway, N. Tubridy, K. Shields, W. K. Cullen, M. J. Rowan, A. R. Moore, M. Rowan, D. Coakley, B. Lawlor, G. Swanwick, R. Al-Naeemi, R. Murphy, N. M. Codd, M. Goggins, N. P. Kennedy, B. L. Mallon, H. Mulcahy, M. Skelly, D. O. Donoghue, D. McCarthy, A. Saunders, D. J. Veale, J. J. F. Belch, D. Breathnach, E. Murphy, G. Kernohan, K. Gibson, A. G. Wilson, G. W. Duff, N. de Vries, L. B. A. van de Putte, J. Donoghue, F. O’Kelly, Z. Johnson, T. Maher, A. Moran, C. Keane, D. O’Neill, N. Horgan, J. M. Barragry, D. M. Campbell, M. Behan, P. R. O’Connell, V. S. Donnelly, D. Crowley, M. Geary, P. Boylan, M. Fanagan, K. Hickey, T. Teoh, M. Doyle, R. Harrison, D. Lyons, Y. Shenouda, M. Coughlan, P. McKenna, P. Lenehan, M. Foley, P. Kelehan, P. Ravichandran, M. Kelly, A. Conroy, C. Fitzpatrick, D. Egan, C. L. Regan, B. V. McAdam, P. McParland, G. A. FitzGerald, D. J. Fitzgerald, S. C. Sharma, K. Foran, C. Barry-Kinsella, R. F. Harrison, F. J. Gillespie, P. O’Mahony, M. Boyle, M. J. White, F. Donohoe, Y. Birrane, M. Naughton, R. B. Fitzsimons, M. Piracha, S. McConkey, E. Griffin, E. Hayes, T. Clarke, N. Parfrey, K. Butler, A. J. Malone, P. J. Kearney, P. F. Duggan, A. Lane, R. Keville, M. Turner, S. Barry, D. Sloan, S. Gallagher, M. Darby, P. Galligan, J. Stack, N. Walsh, M. O’Sullivan, M. Fitzgerald, D. Meagher, S. Browne, C. Larkin, P. Casey, E. O’Callaghan, S. Rooney, E. Walsh, M. Morris, T. Burke, M. Roe, C. Maher, M. Wrigley, M. Gill, M. Burgess, E. Corcoran, D. Walsh, B. Gilmer, C. B. Hayes, L. Thornton, J. Fogarty, R. Lyons, M. O’Connor, V. Delaney, K. Buckley, D. Lillis, V. Delany, C. Hayes, P. Dack, D. Igoe, H. J. O’Neill, P. Kelly, D. McKeown, L. Clancy, G. Varghese, S. Hennessy, J. J. Gilmartin, K. Birthistle, D. Carrington, H. Maguire, P. Atkinson, C. Foley-Nolan, M. Lynch, B. Cryan, D. Whyte, C. Conlon, V. Kucinskas, U. Usinskiene, I. Sakalyte, E. Dawson, K. Molloy, N. Goulden, J. Doyle, E. Lawlor, M. G. Harrington, N. El-Nageh, M. -L. Nolan, J. O’Riordan, G. Judge, G. Crotty, T. Finch, M. Borton, T. Barnes, O. Gilligan, G. Lee, R. Limmer, M. Madden, C. Bergin, A. O’Leary, F. Mulcahy, F. Wallis, M. Glennon, M. Cormican, U. NiRiain, M. Heiginbothom, F. Gannon, T. Smith, C. O’Sullivan, R. Hone, D. A. Caugant, C. A. P. Fijen, E. J. Van Schalkwyk, G. J. Coetzee, U. Ni Riain, M. G. Cormican, L. Park, J. Flynn, V. Regazzoli, M. Hayes, G. Nicholson, P. Higgins, N. Flynn, G. Corbett-Feeney, D. J. Conway, N. J. O’Higgins, S. Rajendiran, J. Byrne, E. Kilfeather, P. Dingle, M. Hunter, S. K. Al-Ghazal, P. Stanley, J. Palmer, A. Hong, P. Saxby, D. Sheehan, I. Regan, J. O’Mullane, M. Ni Chaoimh, M. Leahy, J. J. Heffron, M. Lehane, C. Keohane, N. O’Leary, M. Sheehan, E. Renny-Walsh, M. J. Whelton, C. T. Doyle, J. Webster, N. Benjamin, S. FitzGerald, J. S. Chadha, M. G. FitzGerald, G. R. FitzGerald, L. Hemeryck, P. McGettigan, J. Golden, N. Arthur, S. Y. Wen, P. Deegan, T. Cooke, G. I. Adebayo, P. Gaffney, M. Sinnot, D. O’Riordan, T. Hayes, C. M. O’Connor, M. X. FitzGerald, C. Costello, G. Finlay, J. Hayes, C. O’Connor, K. McMahon, S. Hone, J. Robertson, R. Coakley, S. O’Neill, M. Walsh, J. McCarthy, D. Lannon, A. E. Wood, R. Sharkey, E. Mulloy, M. Long, I. Kilgallen, V. Tormey, S. Horne, T. Feeney, Ó. Ó Muiré, M. J. Griffin, D. Hughes, A. Knaggs, D. Magee, C. McCrory, B. March, D. Phelan, M. White, J. Fabry, D. Buggy, C. Cooney, E. Aziz, D. O’Keefe, A. J. McShane, J. Boylan, E. Tobin, C. Motherway, F. Colreavy, N. Denish, R. Dwyer, A. Bergin, K. O’Brien, R. MacSullivan, K. D. Carson, W. P. Blunnie, D. C. Moriarty, B. Kinirons, B. Lyons, N. Cregg, W. Casey, K. P. Moore, S. A. Colbert, C. Ecoffey, D. O’Gorman, J. Fitzgerald, P. Diamond, M. B. Codd, D. D. Sugrue, J. Kellett, M. Tighe, C. J. McKenna, J. Galvin, H. A. McCann, A. Scallon, A. Fraser, M. Norton, G. Tomkin, I. Graham, A. Byrne, M. Maher, N. Moran, D. Fitzgerald, D. O’Callaghan, D. Coyle, A. G. Nugent, C. McGurk, G. D. Johnston, A. Nugent, B. Silke, N. Murphy, L. Jennings, D. Pratico, C. Doyle, T. Hennessy, H. McCann, D. Sugrue, S. Donnelly, A. Hennessy, C. Hartigan, D. MacDonald, S. Blake, D. McDonald, D. Dominque, S. R. McMechan, G. MacKenzie, J. Allen, G. T. Wright, G. J. Dempsey, M. Crawley, J. Anderson, A. A. J. Adgey, M. T. Harbinson, N. P. S. Campbell, C. M. Wilson, P. K. Ellis, E. M. McIlrath, A. McShane, T. V. Keaveny, K. Rabenstein, F. Scheller, D. Pfeiffer, C. Urban, I. Moser, G. Jobst, A. Manz, S. Verpoorte, F. Dempsey, D. Diamond, M. Smyth, E. Dempsey, V. Hamilton, J. Twomey, R. Crowley, L. Fenelon, F. Walsh, J. McCann, P. McDonagh, E. McGovern, D. Luke, K. Crowley, D. Mannion, D. Murphy, K. Clarkson, E. Carton, I. Leonard, D. O’Toole, M. Staunton, M. Griffin, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, N. A. Herity, J. D. Allen, R. O’Moore, G. M. Crotty, M. DeArce, K. Nikookam, P. Keenan, D. Cregan, N. O’Meara, S. Forman, D. A. Cusack, and B. Farrell
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medicine.medical_specialty ,business.industry ,Family medicine ,medicine ,MEDLINE ,General Medicine ,business - Published
- 1995
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3. Evidence for gene-nutrient interaction at the PPARgamma locus
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David Halsall, Stephen O'Rahilly, V. Krishna K. Chatterjee, Jian'an Luan, Nicholas J. Wareham, Anne-Helen Harding, and Paul O. Browne
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Adult ,Male ,medicine.medical_specialty ,Genotype ,Nutrient interaction ,Endocrinology, Diabetes and Metabolism ,Saturated fat ,Population ,Peroxisome proliferator-activated receptor ,Receptors, Cytoplasmic and Nuclear ,Biology ,Body Mass Index ,Cohort Studies ,Polyunsaturated fat ,Insulin resistance ,Reference Values ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Protein Isoforms ,Nutritional Physiological Phenomena ,Prospective Studies ,Allele ,education ,Alleles ,chemistry.chemical_classification ,education.field_of_study ,Polymorphism, Genetic ,Fatty Acids ,Homozygote ,Middle Aged ,medicine.disease ,Obesity ,Dietary Fats ,Endocrinology ,chemistry ,Fatty Acids, Unsaturated ,Female ,Transcription Factors - Abstract
The importance of the nuclear receptor peroxisome proliferator–activated receptor-γ (PPARγ) in regulating insulin resistance and blood pressure has been demonstrated in families with loss of function mutations. Gain of function mutations has been associated with severe obesity. However, previous population studies of the common variant Pro12Ala have produced conflicting results. As it is likely that the natural ligands for this receptor may include fatty acids, we hypothesized that the effect of this common variant may be altered by the character of the diet, particularly the ratio of dietary polyunsaturated fat to saturated fat (P:S ratio). We studied 592 nondiabetic participants in an ongoing population-based cohort study who were genotyped for the Pro12Ala polymorphism in the PPAR γ2 isoform. As the Ala homozygotes were uncommon (2.0%), all analyses were conducted comparing Pro homozygotes (79.1%) to Ala allele carriers. There was no difference in fasting insulin concentration or BMI between Ala allele carriers and Pro homozygotes. The fasting insulin concentration was negatively associated with the P:S ratio (P = 0.0119) after adjustment for age and sex, and a strong interaction was evident between the P:S ratio and the Pro12Ala polymorphism for both BMI (P = 0.0038) and fasting insulin (P = 0.0097). The data suggest that when the dietary P:S ratio is low, the BMI in Ala carriers is greater than that in Pro homozygotes, but when the dietary ratio is high, the opposite is seen. This gene-nutrient interaction emphasizes the difficulty of examining the effect of common polymorphisms in the absence of data on nongenetic exposures, and may explain the heterogeneity of findings in previous studies.
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- 2001
4. A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis
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Maura Agostini, V. K. K. Chatterjee, P O Browne, Thomas P. Burris, Odelia Rajanayagam, John M. Wentworth, M Adams, C Provenzano, John W.R. Schwabe, Mitch Lazar, T. N. Collingwood, and Mark Gurnell
- Subjects
Peroxisome proliferator-activated receptor gamma ,Transcription, Genetic ,Genetic Vectors ,Peroxisome proliferator-activated receptor ,Receptors, Cytoplasmic and Nuclear ,Biology ,Ligands ,Transfection ,Biochemistry ,Models, Biological ,Adenoviridae ,Cell Line ,Rosiglitazone ,Transactivation ,Enzyme-linked receptor ,Adipocytes ,Humans ,Nuclear Receptor Co-Repressor 2 ,Molecular Biology ,Nuclear receptor co-repressor 2 ,Genes, Dominant ,chemistry.chemical_classification ,Thyroid hormone receptor ,Dose-Response Relationship, Drug ,Cell Biology ,Precipitin Tests ,Cell biology ,DNA-Binding Proteins ,Repressor Proteins ,Thiazoles ,Nuclear receptor ,chemistry ,Mutation ,Cancer research ,Thiazolidinediones ,Corepressor ,Plasmids ,Transcription Factors - Abstract
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) promotes adipocyte differentiation, exerts atherogenic and anti-inflammatory effects in monocyte/macrophages, and is believed to mediate the insulin-sensitizing action of antidiabetic thiazolidinedione ligands. As no complete PPARgamma antagonists have been described hitherto, we have constructed a dominant-negative mutant receptor to inhibit wild-type PPARgamma action. Highly conserved hydrophobic and charged residues (Leu(468) and Glu(471)) in helix 12 of the ligand-binding domain were mutated to alanine. This compound PPARgamma mutant retains ligand and DNA binding, but exhibits markedly reduced transactivation due to impaired coactivator (cAMP-response element-binding protein-binding protein and steroid receptor coactivator-1) recruitment. Unexpectedly, the mutant receptor silences basal gene transcription, recruits corepressors (the silencing mediator of retinoid and thyroid receptors and the nuclear corepressor) more avidly than wild-type PPARgamma, and exhibits delayed ligand-dependent corepressor release. It is a powerful dominant-negative inhibitor of cotransfected wild-type receptor action. Furthermore, when expressed in primary human preadipocytes using a recombinant adenovirus, this PPARgamma mutant blocks thiazolidinedione-induced differentiation, providing direct evidence that PPARgamma mediates adipogenesis. Our observations suggest that, as in other mutant nuclear receptor contexts (acute promyelocytic leukemia, resistance to thyroid hormone), dominant-negative inhibition by PPARgamma is linked to aberrant corepressor interaction. Adenoviral expression of this mutant receptor is a valuable means to antagonize PPARgamma signaling.
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- 2000
5. The Cochrane Collaboration: New Zealand gets involved
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C, Farquhar, S, MacMahon, B, Arroll, S, Hatcher, M O, Browne, D, Wilson, P, Herbison, and C, Silagy
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International Cooperation ,Humans ,New Zealand ,Randomized Controlled Trials as Topic - Published
- 1996
6. Immune status of the neonate maintained on total parenteral nutrition
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E J Guiney, D J Reen, O Browne, and P Puri
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Male ,Parenteral Nutrition ,Time Factors ,Lymphocyte ,T-Lymphocytes ,Physiology ,Immunoglobulins ,Normal values ,Leukocyte Count ,Immune system ,Immunity ,Medicine ,Humans ,Immune status ,B-Lymphocytes ,biology ,business.industry ,Infant, Newborn ,Complement System Proteins ,Infant newborn ,medicine.anatomical_structure ,Parenteral nutrition ,Pediatrics, Perinatology and Child Health ,Immunology ,biology.protein ,Female ,Parenteral Nutrition, Total ,Antibody ,business ,Research Article - Abstract
Immunological studies were carried out on 7 neonates maintained on total parenteral nutrition for periods ranging from 14 to 31 days after surgery for correction of gastrointestinal anomalies. IgM and IgA levels were high in all patients but IgG levels were low, compared with normal values. Total leucocyte counts, absolute lymphocyte counts, and T- and B-lymphocytes in all patients were similar to those of healthy controls. Neonates maintained on adequate total parenteral nutrition showed no evidence of impairment of immune function.
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- 1981
7. Carcinoma of the oesophagus associated with membrano-proliferative glomerulonephritis
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G. D. Doyle, S. O'Neil, O. Browne, M. Carmody, W. F. O'Dwyer, E. Campbell, and J. F. Walker
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Pathology ,medicine.medical_specialty ,Renal lesion ,Proteinuria ,Nephrotic Syndrome ,Esophageal Neoplasms ,business.industry ,Kidney Glomerulus ,Glomerulonephritis ,General Medicine ,Middle Aged ,medicine.disease ,Clear urine ,Carcinoma ,Carcinoma, Squamous Cell ,Medicine ,Humans ,Female ,medicine.symptom ,business ,Nephrotic syndrome ,Research Article - Abstract
Summary Nephrotic syndrome has been observed in association with different types of neoplasia. This appears to be the first report of the occurrence of the nephrotic syndrome due to membrano proliferative glomerulonephritis in association with carcinoma of the oesophagus. Although proteinuria was present before excision of the tumour, the nephrotic phase occurred subsequently. Eventually it disappeared leaving the patient with a clear urine and biochemical and histological improvement of the renal lesion (including immunofluorescent and electronmicroscopy studies). Possible mechanisms responsible for the nephrotic syndrome in this case are discussed.
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- 1981
8. A coastal Chumash village: excavation of Shisholop, Ventura County, California
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Roberta S. Greenwood, John E. Fitch, and R. O. Browne
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Geography ,Excavation ,Archaeology - Published
- 1969
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9. Trichlorethylene analgesia in labour; observations on its use in the Rotunda Hospital
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O, BROWNE, V, McCORMICK, and F, DE WHYTE
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Labor, Obstetric ,Pregnancy ,Humans ,Anesthesia ,Female ,Articles ,Analgesia ,Anesthesia, Inhalation ,Trichloroethylene - Published
- 1951
10. Toxaemic accidental haemorrhage observations on its etiology, phases and treatment
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O, BROWNE
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Pre-Eclampsia ,Pregnancy ,Section of Obstetrics and Gynæcology ,Placenta ,Toxemia ,Humans ,Female ,Abruptio Placentae - Published
- 1952
11. Dietary practice and nutritional status of low-income earners in a rural adult population in Delta State, Nigeria: a cross-sectional study.
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Christabel ON, Peters E, Otovwe A, Browne O, and Richard AA
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- Humans, Cross-Sectional Studies, Nigeria, Male, Female, Adult, Middle Aged, Young Adult, Obesity epidemiology, Adolescent, Surveys and Questionnaires, Aged, Malnutrition epidemiology, Sex Factors, Nutritional Status, Rural Population statistics & numerical data, Feeding Behavior, Poverty statistics & numerical data, Health Knowledge, Attitudes, Practice, Diet statistics & numerical data
- Abstract
Introduction: due to the inability of low-income populations to access nutritious foods or basic education, these groups usually consume unhealthy diets, which frequently lead to nutrition issues like obesity, malnutrition, and other health morbidities. The purpose of the study was to evaluate the nutritional knowledge, dietary practices, nutritional status, and factors influencing the dietary habits of low-income persons living in a rural constituency in Southern Nigeria., Methods: a cross-sectional study was carried out on 419 consenting low-income adults (18 years and older) using a simple random technique, in order to collect data on their socio-demographic traits, nutritional knowledge, dietary practices, and nutritional status. Statistical Package for Social Sciences (SPSS) version 22.0 was used to analyze the data generated., Results: the respondents´ the average age was 40.9 ± 15.68 years while 224 (53.5%) of those surveyed were females. The proportion of responders with a secondary education was highest 279 (66.6%). The most common occupation among respondents was farming 151 (36.1%) and petty trading 135 (32.2%). Overall, 314 (74.9%) of low-income adults had poor dietary habits, and 245 (60.6%) had poor nutrition knowledge. Occupation and gender were significantly associated with nutritional status P<0.05. The majority of respondents 56.2% (235) were overweight or obese, and multivariate logistic regression analysis shows that respondents with concern about gaining weight were more likely to be overweight or obese (OR=1.065, 95% CI=0.832-1.363)., Conclusion: the findings from the study indicate that inadequate nutritional knowledge and poor dietary habits, reflected in respondents' body weight are likely to increase the risk of non-communicable diseases, necessitating the need for nutritional education among rural populations., Competing Interests: The authors declare no competing interests., (Copyright: Ogbolu Nneka Christabel et al.)
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- 2024
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12. Hydrogen-Bonded Complexes in Binary Mixture of Imidazolium-Based Ionic Liquids with Organic Solvents.
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Rush K, Islam MM, Nawagamuwage SU, Marzette J, Browne O, Foy K, Reyes K, Hoang M, Nguyen C, Walker A, Ferrufino Amador S, Riglioni E, Rubtsov IV, Riley K, and Dutta S
- Abstract
Though local structures in ionic liquids are dominated by strong Coulomb forces, directional hydrogen bonds can also influence the physicochemical properties of imidazolium-based ionic liquids. In particular, the C-2 position of the imidazolium cation is acidic and can bind with suitable hydrogen bond acceptor sites of molecular solvents dissolved in imidazolium-based ionic liquids. In this report, we identify hydrogen-bonded microenvironments of the model ionic liquid, 1-ethyl-3-methylimidazolium tris(pentafluoroethyl) trifluorophosphate, and the changes that occur when molecular solvents are dissolved in it by using a C-D infrared reporter at the C-2 position of the cation. Our linear and nonlinear infrared experiments, along with computational studies, indicate that the molecular solvent dimethyl sulfoxide can form strong hydrogen-bonded dimers with the cation of the ionic liquid at the C-2 position. In contrast, acetone, which is also a hydrogen bond acceptor similar to dimethyl sulfoxide, does not show evidence of cation-solvent hydrogen-bonded conformers at the C-2 position. The outcome of our study on a broad scale strengthens the importance of cation-solute interactions in ionic liquids.
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- 2023
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13. Improved stroke care processes and outcomes following the institution of an acute stroke unit at a New Zealand district general hospital.
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Burgess NG, Vyas R, Hudson J, Browne O, Lee YC, Jayathissa S, and Thomson T
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- Age Factors, Aged, Chi-Square Distribution, Cohort Studies, Critical Care organization & administration, Female, Hospitals, General, Humans, Length of Stay, Male, Medical Audit, New Zealand, Patient Care Team organization & administration, Quality Improvement, Retrospective Studies, Risk Factors, Sex Factors, Stroke diagnosis, Survival Analysis, Hospital Mortality, Hospital Units organization & administration, Outcome and Process Assessment, Health Care, Stroke mortality, Stroke therapy
- Abstract
Aims: To examine whether stroke care processes and outcomes are improved following the institution of an acute stroke unit (ASU) at a medium-sized New Zealand hospital., Methods: Two retrospective audits over 12-month periods were carried out at Hutt Valley Hospital before and after the institution of a 6-bed ASU. Data was collected on demographics, length of stay, stroke type, investigations, processes of care and outcomes., Results: 139 strokes pre ASU and 155 strokes post ASU were studied. 86.8% of strokes received stroke unit care in the 2009 audit. There were more intracerebral haemorrhages in 2006 (17.2% vs. 9.0%). Significant improvements were seen between 2006 and 2009 in time to aspirin administration (52.7 versus 14.5 hours), swallow assessment within 24 hours (88.5% versus 96.1%), lag time to carotid Doppler studies (21 days versus 4.5 days), pressure risk assessments (19.6%, versus 87.2%) and urinary infection rates (10.8% versus 2.0% ). Total length of stay (TLOS) and mortality were reduced but the difference was not statistically significant. (20.5 days versus 18.3 days p=0.34, Inpatient mortality 16.2% versus 10% p=0.12)., Conclusions: The introduction of an ASU has resulted in improvements in several key processes of stroke care. Overall mortality and total length of stay showed a trend to improvement after the establishment of an ASU.
- Published
- 2012
14. Immune status of the neonate maintained on total parenteral nutrition.
- Author
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Puri P, Reen DJ, Browne O, and Guiney EJ
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- B-Lymphocytes immunology, Complement System Proteins analysis, Female, Humans, Immunoglobulins analysis, Leukocyte Count, Male, T-Lymphocytes immunology, Time Factors, Immunity, Infant, Newborn, Parenteral Nutrition, Parenteral Nutrition, Total
- Abstract
Immunological studies were carried out on 7 neonates maintained on total parenteral nutrition for periods ranging from 14 to 31 days after surgery for correction of gastrointestinal anomalies. IgM and IgA levels were high in all patients but IgG levels were low, compared with normal values. Total leucocyte counts, absolute lymphocyte counts, and T- and B-lymphocytes in all patients were similar to those of healthy controls. Neonates maintained on adequate total parenteral nutrition showed no evidence of impairment of immune function.
- Published
- 1981
- Full Text
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15. The enhancing influence of proteolysis on E rosette forming lymphocytes (T cells) in vivo and in vitro.
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Holland PD, Browne O, and Thornes RD
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- Adolescent, Adult, Aged, Brinolase pharmacology, Female, Humans, Immune Adherence Reaction, Male, Middle Aged, Streptokinase pharmacology, T-Lymphocytes immunology, Neoplasms immunology, Peptide Hydrolases pharmacology, T-Lymphocytes drug effects
- Abstract
The T lymphocytes populations of 22 young healthy adults, 21 healthy middle aged and older blood donors, 35 non-pregnant women of child bearing age and 14 patients with advanced malignant disease were assessed and compared. It was found that the mean T cell counts in the middle aged and older controls were significantly lower than in the healthy young adults and were further reduced in the patients with malignant disease. The addition of the proteolytic agent brinase (protease 1 obtained from Aspergillus oryzae) to the rosetting test increased the T cell counts signficantly in all groups. This was mot marked in the older age groups and the patients with malignant disease. The proteolytic agent is shown to exert its effect on the lymphocytes in the test. Slow intravenous infusion of either brinase or streptokinase into patients with malignant disease is shown to result in increased T lymphocyte counts pari passu with a restoration of skin allergy. The significance of these findings and possible mode of action of the proteolytic agents in increasing T cell activity are discussed.
- Published
- 1975
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16. Lymphocyte response after surgery in the neonate.
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Puri P, Reen DJ, Browne O, Blake P, and Guiney EJ
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- Anesthesia, Inhalation, B-Lymphocytes, Congenital Abnormalities immunology, Congenital Abnormalities metabolism, Female, Humans, Infant, Newborn, Leukocyte Count, Lymphocyte Activation, Lymphocytes metabolism, Male, Phytohemagglutinins, Postoperative Period, T-Lymphocytes, Thymidine metabolism, Congenital Abnormalities surgery, Lymphocytes immunology
- Abstract
Fourteen neonates born with congenital malformations were investigated for lymphocyte function before and after surgery. Total leucocyte and absolute lymphocyte counts were unaltered after surgery. The mean percentage of T-lymphocytes observed either pre- or postoperatively was considerably lower than that reported in older children and adults. While there was an increase in the percentage of B-lymphocytes after operation in the infants, the absolute number of B-cells remained unchanges. The preoperative transformation response of lymphocytes to PHA (mean 12.9 +/- 5.4 X 10(3) counts/min) was little different from the postoperative values (mean 12.4 +/- 4.4 X 10(3) counts/min). These results suggest that the neonate is immunologically different from older children and adults in its response to anaesthesia and surgery.
- Published
- 1979
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17. Carcinoma of the oesophagus associated with membrano-proliferative glomerulonephritis.
- Author
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Walker JF, O'Neil S, Campbell E, Browne O, Doyle G, Carmody M, and O'Dwyer WF
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- Female, Glomerulonephritis pathology, Humans, Kidney Glomerulus pathology, Middle Aged, Carcinoma, Squamous Cell complications, Esophageal Neoplasms complications, Glomerulonephritis etiology, Nephrotic Syndrome etiology
- Abstract
Nephrotic syndrome has been observed in association with different types of neoplasia. This appears to be the first report of the occurrence of the nephrotic syndrome due to membrano proliferative glomerulonephritis in association with carcinoma of the oesophagus. Although proteinuria was present before excision of the tumour, the nephrotic phase occurred subsequently. Eventually it disappeared leaving the patient with a clear urine and biochemical and histological improvement of the renal lesion (including immunofluorescent and electronmicroscopy studies). Possible mechanisms responsible for the nephrotic syndrome in this case are discussed.
- Published
- 1981
- Full Text
- View/download PDF
18. Trichlorethylene analgesia in labour; observations on its use in the Rotunda Hospital.
- Author
-
BROWNE O, McCORMICK V, and DE WHYTE F
- Subjects
- Female, Humans, Pregnancy, Analgesia, Anesthesia, Anesthesia, Inhalation, Labor, Obstetric, Trichloroethylene
- Published
- 1951
- Full Text
- View/download PDF
19. Sulphathiazole Insufflations as Treatment of Gonococcal Vaginitis.
- Author
-
Browne O
- Published
- 1943
- Full Text
- View/download PDF
20. Toxaemic accidental haemorrhage observations on its etiology, phases and treatment.
- Author
-
BROWNE O
- Subjects
- Female, Humans, Pregnancy, Abruptio Placentae, Placenta, Pre-Eclampsia, Toxemia
- Published
- 1952
21. SHOCK FOLLOWING BLOOD EXTRAVASATION.
- Author
-
Browne O
- Published
- 1931
- Full Text
- View/download PDF
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