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Based on the analysis of clinical and experimental studies, an attempt to explain pleiotropic effects of statins and their numerous action mechanisms has been performed. The pleiotropic effect concept includes: (a) medication effects on numerous targets, triggering various biochemical processes in the organism; b) the divergence of bio­chemical and pathophysiological processes triggered by one target. The pathochemical mechanisms of statins’ effects as HMG-CoA reductase inhibitors are explained. The authors also justify the independence of therapeutic and adverse effects of statins from their lipid and cholesterol-related mechanisms of action.

Summarizing and analyzing the information on the role of neurotrophic and growth factors in vascular pathology, arterial hypertension (AH), and organ damage (OD) pathogenesis, enables us to set new targets for treatment strategy. It is more and more evident that, besides the systems of peptide regulators (angiotensin II, endothelin-1, atrial natriuretic factors), catecholamines, etc., cardiovascular pathology pathogenesis is influenced by polypeptide growth and neurotrophic factors, participating in the complex chemical regulation process. They act as regulators of normal and pathological processes, and are directly linked with the triade “oxidative stress-inflammation-endothelial dysfunction”, that is crucial in AH and OD pathogenesis. Among these factors, the most prospective are: endothelial vascular growth factor, insulin-like growth factors, platelet growth factor, transforming growth factors, fibroblast growth factor, tumor necrosis factor. Structural and functional features of these substances, together with their role as possible mediators and/or predictors and targets in vascular pathology processes, are described in this article.

Aim. During 12-week perindopril (PR) and hypothiazide (HT) therapy, to study its antihypertensive efficacy, as well as its influence on endothelial function (EF) and angiotensin-converting enzyme (ACE) serum activity, in patents with essential arterial hypertension (EAH). Material and methods. The study included 20 males (mean age 48.8±8.4 years) with mild to moderate AH. Antihypertensive efficacy was assessed during office BP measurement (Korotkoff method) and 24-hour blood pressure monitoring (BPM). EF was assessed by endothelium-dependent vasodilatation (EDVD) during reactive hyperemia test (RHT). Results. According to office BP measurements, target BP level (

Significance of baseline ACE activity in patients with metabolic syndrome when administration of ACE inhibitors and imidazoline agonists is considered.