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Background: Studies addressing the training-induced neuroplasticity and interrelationships of the lip, masseter, and tongue motor representations in the human motor cortex using single syllable repetition are lacking. Objective: This study investigated the impact of a repeated training in a novel PaTaKa diadochokinetic (DDK) orofacial motor task (OMT) on corticomotor control of the lips, masseter, and tongue muscles in young healthy participants. Methods: A total of 22 young healthy volunteers performed 3 consecutive days of training in an OMT. Transcranial magnetic stimulation was applied to elicit motor evoked potentials (MEPs) from the lip, masseter, tongue, and first dorsal interosseous (FDI, internal control) muscles. MEPs were assessed by stimulus–response curves and corticomotor mapping at baseline and after OMT. The DDK rate from PaTaKa single syllable repetition and numeric rating scale (NRS) scores were also obtained at baseline and immediately after each OMT. Repeated-measures analysis of variance was used to detect differences at a significance level of 5%. Results: There was a significant effect of OMT and stimulus intensity on the lips, masseter, and tongue MEPs compared to baseline (p .05). OMT increased corticomotor topographic maps area (p

This cross-sectional observational study with 24 patients evaluated differences in bite force (BF) and masticatory performance (MP) between conventional complete denture (CCD) and implant mandibular overdenture (IMO) users and the correlation between these variables. The BF test was performed bilaterally with an occlusal force device. During the MP test, patients were asked to chew Optocal particles for 40 cycles. The Shapiro Wilk test was employed to verify the normality of the data, the student t test to identify differences between groups, and Pearson’s correlation to investigate interrelationships between variables. A multiple linear regression was subsequently performed via the stepwise method. P values ≤0.05 were considered statistically significant. Unlike IMO users, CCD users presented a significant difference (25.6%) in BF between the dominant and non-dominant chewing side (p=0.04). IMO users presented significantly higher BF (p=0.01) without presenting a dominant side (p=0.38), and also performed significantly better for the following MP parameters: MPX50 values decreased by 27.25% in IMO users (p=0.01), MPB decreased by 48.38% (p=0.01), and ME 5.6 decreased by 53.25% (p=0.02), while ME2.8 increased by 151.57% (p=0.01). The BF and MPX50 in the IMO wearers group were negatively correlated (-0.57; p=0.05); this correlation coefficient was the only parameter included in the multivariate regression model. IMO users have higher BF and better masticatory performance than CCD users, especially in terms of chewed particles size reduction. MP is correlated with a higher BF in IMO users through better particle trituration. Resumo Este estudo observacional transversal com 24 participantes teve como objetivo avaliar as diferenças na força de mordida (FM) e na PM (performance mastigatória) entre usuários de prótese total convencional (PTC) e de overdenture mandibular (OM) e a correlação entre essas variáveis. O teste de FM foi realizado bilateralmente com um dispositivo de força oclusal. Durante o teste de PM, os pacientes foram solicitados a mastigar uma porção padronizada de Optocal por 40 ciclos mastigatórios. O teste de Shapiro Wilk foi empregado para verificar a normalidade dos dados, o teste T de Student para identificar diferenças entre os grupos e os coeficientes de correlação de Pearson para investigar inter-relações entre variáveis. Uma regressão linear múltipla foi realizada pelo método stepwise. Valores de p≤0,05 foram considerados estatisticamente significantes. Diferentemente dos usuários de OM, os usuários de PTC apresentaram uma diferença significativa (34%) na FM entre o lado dominante e o não dominante (p=0,04). Os usuários de OM apresentaram FM significativamente maior (p=0,01) sem apresentar um lado dominante (p=0,38) e obtiveram PM significativamente melhor nos seguintes parâmetros: os valores de PMX50 diminuíram 27,25% (p=0,01), PMB diminuiu em 48,38% (p=0,01), e EM 5.6 diminuiu 53,25% (p=0,02), enquanto EM2.8 aumentou 151,57% (p=0,01). A FM e PMX50 no grupo de usuários da IMO foram negativamente correlacionados (-0,57;p=0,05); esse coeficiente de correlação foi o único parâmetro incluído no modelo de regressão multivariada. Os usuários da OM possuem maior FM e melhor performance mastigatória do que os usuários de PTC, observados principalmente na redução do tamanho das partículas mastigadas. A PM está correlacionada com um maior FM nos usuários da OM através de uma melhor trituração de partículas.

OBJETIVO: Averiguar o impacto de fatores socioeconômicos e psicossociais na qualidade de vida de pacientes oncológicos.MÉTODOS: 100 indivíduos aceitaram participar do estudo no periódo de agosto/2015 a fevereiro/2016. Foram aplicados questionários para coleta de dados socioeconômicos, qualidade de vida(WHOQOL-bref), senso de coerência (SOC), autopercepção de felicidade e ansiedade e depressão (HADS).Foi utilizado o teste ANOVA para associação dos dados sociodemográficos com os sitios do tumores e os domínios do WHOQOL-bref além dos outros itens estudados.RESULTADOS: A amostra foi composta por 57 homens e 43 mulheres, com idade média de 59,11 anos. Entre todos os domínios do WHOQOL-bref (físico, psicológico, relações sociais e meio ambiente), a renda familiar baixa e o câncer de cabeça e pescoço influenciaram para pior percepção de qualidade de vida. No domínio psicológico e meio ambiente, o sexo masculino (p=0,04) demonstrou pior qualidade de vida. Os indivíduos idosos (60-82 anos, p=0,008) e solteiros ou divorciados (p=0,0008) apresentaram pior qualidade de vida no domínio social. O baixo do senso de coerência revelou pior percepção de qualidade de vida em todos os domínios do WHOQOL(p

The aim of this randomized clinical trial was to compare the occurrence and intensity of postoperative pain and analgesic intake after root canal treatment, using different root canal sealers. Sixty single-rooted teeth diagnosed with asymptomatic necrosis and apical periodontitis were randomly assigned to 3 experimental groups (n=20), according to the root canal sealer: AH Plus, Endofill or MTA Fillapex. Endodontic treatment was performed in two sessions, and calcium hydroxide was used as the intracanal dressing. Patients were instructed to record pain intensity as none, slight, moderate and severe. Scores from 1 to 4 were attributed to each level of pain after 24 h, 48 h and 7 days. The need for analgesic intake was also recorded. Differences in the incidence of postoperative pain and the need for an analgesic were analyzed using the chi-square test. Differences in pain intensity after treatment were analyzed using the ordinal (linear) chi-square test. No significant differences were detected among the groups in terms of either incidence or intensity of postoperative pain, or need for analgesic intake, at any timepoint (p>0.05). No pain was reported after 7 days. AH Plus, Endofill and MTA Fillapex used for filling root canals resulted in the same rate of postoperative pain and need for analgesic medication.

This randomized clinical trial evaluated the influence of the type of intraradicular posts (glass fiber post or cast metal post) in the success of endodontic treatment in teeth that received single metal-ceramic restoration. The sample consisted of adult patients, who presented for the first time seeking routine dental care at the dental school over a period of 5 years. Seventy-six out of ninety-six teeth that received endodontic treatment and intraradicular post were analyzed, randomly distributed in two groups – glass fiber post (n=38), and cast metal post (n=38). The quality of the endodontic treatment was radiographically evaluated, and the apical status was assessed using the periapical index (PAI). Statistical Analyses were performed to a significance level of 5%. Descriptive analyses were used to characterize the teeth and survival curves were created using the Kaplan–Meier method. The success rate of endodontic treatment was 90.8% (n=69) including glass fiber post and cast post. When appropriate endodontic treatment was performed is possible to conclude that the success of endodontic treated teeth that received posts was not related to the post type. Este ensayo clínico aleatorizado evaluó la influencia del tipo de postes intrarradiculares (postes de fibra de vidrio o postes de metal fundido) en el éxito del tratamiento de endodoncia en los dientes que recibieron restauración de metal-cerámica simple. La muestra estuvo conformada por pacientes adultos, quienes acudieron por primera vez buscando atención odontológica de rutina en la facultad de odontología durante un período de 5 años. Se analizaron setenta y seis de los noventa y seis dientes que recibieron tratamiento endodóntico y poste intrarradicular, que consistieron en dos grupos: poste de fibra de vidrio (n = 38) y poste de yeso (n = 38). La calidad del tratamiento endodóntico se evaluó radiográficamente y el estado apical se evaluó mediante el índice periapical (PAI). Los análisis estadísticos se realizaron a un nivel de significancia del 5%. Se utilizaron análisis descriptivos para caracterizar los dientes y se crearon curvas de supervivencia mediante el método de Kaplan-Meier. La tasa de éxito del tratamiento endodóntico fue del 90,8% (n = 69), incluidos los postes de fibra de vidrio y los postes de yeso. Cuando se realizó el tratamiento de endodoncia adecuado, es posible concluir que el éxito de los dientes tratados con endodoncia que recibieron postes no estuvo relacionado con el tipo de postes. Este ensaio clínico randomizado avaliou a influência do tipo de pino intrarradicular (pino de fibra de vidro ou pino de metálico-fundido) no sucesso do tratamento endodôntico em dentes que receberam restauração metalocerâmica. A amostra foi composta por pacientes adultos, que se apresentaram pela primeira vez em busca de atendimento odontológico de rotina na faculdade de odontologia durante um período de 5 anos. Foram analisados ​​setenta e seis dos noventa e seis dentes que receberam tratamento endodôntico e pino intrarradicular, aleatoriamente distribuídos em dois grupos - pino de fibra de vidro (n = 38) e pino metálico-fundido (n = 38). A qualidade do tratamento endodôntico foi avaliada radiograficamente e o estado apical foi avaliado pelo índice periapical (PAI). As análises estatísticas foram realizadas a um nível de significância de 5%. Análises descritivas foram utilizadas para caracterizar os dentes e as curvas de sobrevivência foram criadas usando o método de Kaplan-Meier. A taxa de sucesso do tratamento endodôntico foi de 90,8% (n = 69) incluindo pino de fibra de vidro e pino metálico-fundido. Concluindo, quando foi realizado o tratamento endodôntico adequado, o sucesso da terapia endodôntica não teve relação com tipo de pino intraradicular.

This study evaluated the association between the diagnosis of sleep bruxism (SB), scored by way of polysomnographic (PSG) recordings, clinical conditions and sleep architecture.A case-control study was conducted. All records from adults who had undergone polysomnography (PSG) recordings at a private medical outpatient clinic between January 2015 and December 2017 were reviewed. The sample included 58 bruxers (case group) and 58 non-bruxers (control group), identified based on the PSG recording and matched by sex and age.Obese individuals had significantly lower chance (OR 0.18; 95 % CI: 0.05-0.62; P = 0.005) of an SB diagnosis than individuals with normal BMI. Alcohol consumption significantly increased (OR 2.74; 95 % CI: 1.11-6.78; P = 0.029) and OSA decreased the chances (OR 0.55; 95 % CI: 0.23-1.30; P = 0.173) of an SB diagnosis. Bruxers had a significantly shorter wake time after sleep onset (WASO) (p = 0.002). As far as non-rapid eye movement (NREM) is concerned, the duration of stage N1 was statistically shorter (p = 0.034) and the duration of stage N3 was statistically longer (p = 0.001) in bruxers. Arousals (p = 0.013), arousals per hour (p = 0.009), respiratory disturbance index (RDI) values (p0.0005) and the apnoea-hypopnea index (AHI) (p = 0.002) were all lower in bruxers than in non-bruxers.The results of this study support a significant association between SB diagnosis, BMI and alcohol consumption. SB modified the sleep architecture as statistically significant differences were found between bruxers and non-bruxers for WASO, NREM stage N1 and N3, arousals, arousals per hour, RDI and AHI.

The influence of inorganic filler content of resin-based luting agents (RBLAs) on color change (ΔE00), CIEL*a*b* (individual color coordinates), and translucency parameters (TP) of simulated ceramic laminate veneer (CLV) was investigated. RBLAs with low, intermediate, and high inorganic filler content (55%, 65%, and 75% mass fractions, respectively) were prepared. Feldspar ceramic (Vitablocs Mark II) specimens (1.2 mm × 0.8 mm, A1C shade) were bonded to simulated composite resin substrates (1.6 mm × 1.2 mm, A2D shade) using three experimental and a commercial (RelyX Veneer) RBLA (translucent shade). The ΔE00 was calculated by CIEDE2000 color difference metric under three conditions (before, immediately after, and 24 h after luting). The TP was calculated using CIEL*a*b* color coordinates measured over white and black backgrounds. Surface morphology of the RBLAs was analyzed. One-way and two-way analyses of variance with a post-hoc Tukey’s test were used respectively to calculate TP, CIEL*a*b* coordinates, and ΔE00 (α= 0.05). Overall, the tested RBLAs presented clinically visible ∆E00 values under the three conditions evaluated. For all RBLAs, higher ∆E00 values were observed between measurements obtained before and immediately after luting. Different inorganic filler content did not significantly increase the opacity of the ceramic-luting agents-resin composite set. The variation in inorganic filler content did not influence significantly the TP of simulated CLV; although all of the experimental RBLAs tested yielded ∆E00 above the perceptibility threshold. The L*, a*, and b* individual color coordinates were cementation-dependent.

This study evaluated the effect of the accelerated artificial aging (AAA) on feldspar ceramic strength and the reinforcing effect promoted by adhesive cementation with resin luting agent. One hundred twenty feldspar ceramic disks were obtained. Sixty disks were acid-etched, silanized, and coated with an experimental resin luting agent simulating the adhesive luting procedures. Four groups were created (n=30): uncoated ceramic (control group), uncoated ceramic submitted to AAA, ceramic coated with resin luting agent, and coated ceramic submitted to AAA. Biaxial flexural testing with ball-on-ring setup was carried out. Biaxial flexural strength (s bf , MPa), characteristic strength (s 0 , MPa), and Weibull modulus (m) were calculated for axial positions z=0 (ceramic surface) and z=−t2 (luting agent surface). Data of s bf at positions z=0 and z=-t2 were separately submitted to statistical analyses (a=0.05). The uncoated ceramic submitted to AAA had no significant difference in s bf and s 0 compared with the control group. Resin coating of the ceramic increased s bf and s 0 at z=0. The AAA increased the s bf and s 0 for the resin-coated ceramic specimens at z=0 and also the s 0 at axial position z=-t2. The structural reliability at z=0 and z=-t2 was not influenced by the variables tested. In conclusion, resin coating improved the mechanical strength of the feldspar ceramic. The AAA procedure was not effective in aging the uncoated or resin-coated feldspar ceramic specimens. Resumo Este estudo avaliou o efeito do envelhecimento artificial acelerado (EAA) na resistência da cerâmica feldspática e o reforço promovido pela cimentação adesiva com cimento resinoso. Cento e vinte discos de cerâmica feldspática foram obtidos. Sessenta discos foram condicionados com ácido, silanizados, e recobertos com um cimento resinoso experimental simulando os procedimentos de cimentação adesiva. Quatro grupos foram criados (n=30): cerâmica sem recobrimento (grupo controle), cerâmica sem recobrimento submetida ao EAA, cerâmica recoberta com cimento resinoso, cerâmica recoberta com cimento resinoso submetida ao EAA. O teste de resistência à flexão biaxial foi realizado utilizando o dispositivo pistão-anel. Resistência à flexão biaxial (s fb , MPa), resistência característica (s 0 , MPa), e módulo de Weibull (m) foram calculados para as posições axiais z=0 (superfície da cerâmica) e z=−t2 (superfície do cimento). Os dados de s fb em z=0 e z=−t2 foram submetidos a análises estatísticas separadamente (a=0,05). A cerâmica não recoberta submetida ao EAA não teve diferença significante na s fb e s 0 comparada com o grupo controle. O recobrimento com cimento resinoso da cerâmica aumentou a s fb e s 0 em z=0. O EAA aumentou a s fb e s 0 para os espécimes de cerâmica recobertos com cimento resinoso em z=0 e também a s 0 em z=−t2. A confiabilidade em z=0 e z=−t2 não foi influenciada pelas variáveis testadas. Concluindo, o recobrimento com cimento resinoso melhorou a resistência mecânica da cerâmica feldspática. O procedimento de EAA não foi efetivo em envelhecer os espécimes de cerâmica feldspática recobertos ou não com cimento resinoso.

This study evaluated the masking ability of different porcelain thicknesses and combination of enamel and/or dentin porcelain layers over simulated background dental substrates with higher (A2) and lower (C4) color values. Combination of the enamel (E) and dentin (D) monolayer porcelain disks with different thicknesses (0.5 mm, 0.8 mm, and 1 mm) resulted in the following bilayer groups (n=10): D1E1, D1E0.8; D1E0.5; D0.8E0.8; D0.8E0.5, and D0.5E0.5. CIELAB color coordinates were measured with a spectrophotometer. The translucency parameter of mono and bilayer specimens and the masking ability estimated by color variation (ΔE*ab) of bilayer specimens over simulated dental substrates were evaluated. Linear regression analysis was used to investigate the relationships translucency parameter × ΔE*, translucency parameter × porcelain thickness, and ΔE* × porcelain thickness. Data were analyzed statistically (α= 0.05). Thinner porcelain disks were associated with higher translucency. Porcelain monolayers were considerably more translucent than bilayers (enamel + dentin). Dentin porcelain was less translucent than enamel porcelain with same thickness. ΔE* was always lower when measured over A2 background. Higher ΔE* was observed for the C4 background, indicating poorer masking ability. Increased ΔE* was significantly associated with increased translucency for both backgrounds. Decreased translucency and ΔE* were associated with increased total porcelain thickness or increased dentin thickness for both backgrounds. In conclusion, increased porcelain thickness (particularly increased dentin layer) and increased porcelain opacity resulted in better masking ability of the dental backgrounds.

The type of resin-based luting agent might influence the color stability of ceramic veneers.The purpose of this study was to investigate the effects of resin-based agents and aging on the color stability of ceramic veneers bonded to enamel.Ceramic disks were cemented to bovine enamel disks with 4 resin-based luting agents (n=10): dual-polymerizing cement (RelyX ARC), light-polymerizing cement (RelyX Veneer), flowable composite resin (Filtek Z350 Flow), or composite resin preheated for 30 minutes at 60°C (Filtek Z350 XT). CIE L*, a*, and b* color coordinates were measured 24 hours after cementation (baseline) with a color spectrophotometer and reevaluated after 10,000 and 20,000 thermal cycles. Color variation was calculated by using CIELab (ΔE*(ab)) and CIEDE2000 (ΔE00) methods. Then 95% confidence intervals were calculated for color variation means between baseline and 10,000 thermal cycles and between 10,000 and 20,000 thermal cycles. The 95% confidence intervals were also calculated for the means of individual color coordinates (L*, a*, and b*).The dual-polymerizing cement had the highest color variation among all luting agents. No significant differences were found in color variation among the light-polymerizing materials. All agents showed ΔE*(ab)3.46 and ΔE002.25 after 20,000 thermal cycles. Variations in L*, a*, and b* coordinates were material dependent. The dual-polymerizing agent was yellowish and reddish after aging.The dual-polymerizing cement had higher color variation than the light-polymerized materials when used for bonding ceramic veneers to enamel. Flowable and preheated composite resins had similar color stability to that of light-polymerizing resin-based cement.

Objectives: A systematic review and meta-analysis of diagnostic test accuracy studies was conducted to assess if the radiomorphometric indexes observed in panoramic radiographies could estimate reduced bone mineral density (BMD) similarly to standard technique the bone densitometry (dual energy X-ray absorptiometry) in females older than 30 years. Methods: A systematic search in four databases was conducted until January 2019. Two evaluators performed data extraction and evaluation of risk of bias independently, and agreement was achieved by consensus. Data were synthesized on a subgroup meta-analysis with a random effect model and the hierarchical summary receiver-operating characteristic curve was used to calculate pooled estimates of studies. Results: Thirty three studies were included and 12 different radiomorphometric indexes identified, including Mandibular Cortical Index (MCI). The final number of cases pooled for the analysis was 5266 females.The MCI for BMD loss (osteopenia) presented values of sensitivity 0.81 [95% confidence interval (CI), 0.78–0.84] and specificity 0.48 (95% CI, 0.45–0.50), while for osteoporosis sensitivity 0.35 (95% CI, 0.30–0.40) and specificity 0.88 (95% CI, 0.86–0.90). The mandibular cortical width presented values of sensitivity 0.58 (95% CI, 0.40–0.73), specificity 0.73 (95% CI, 0.60–0.83) for osteopenia, while for osteoporosis sensitivity 0.57 (95% CI, 0.36–0.76) and specificity 0.83 (95% CI, 0.68–0.92). Due to the high sensitivity, MCI presented a potential value as a screening tool for initial BMD loss (osteopenia), once tests presenting high sensitivity are described as rarely missing subjects with the disease. To the other hand, MCI to osteoporosis and Mandibular Cortical Width for both conditions are not recommended because presented specificity higher than sensitivity. Conclusion: The MCI can be recommended as a feasible tool to screen initial BMD loss (osteopenia) in females above 30 years old using panoramic radiography exams.

a b s t r a c t Objectives: This randomised clinical trial assessed how biofilm development and composition is affected by time and denture material type in denture wearers with and without denture stomatitis. Methods: Specimens of acrylic resin (control) and denture liners (silicone-based or acrylic resin based, depending on the experimental phase) were inserted into the surface intaglio of 30 denture wearers. Biofilm was formed in two phases of 21 days, and counts of viable microorganisms in the accumulating biofilm were determined after 7, 14 and 21days of biofilm formation. Data were analysed by three-way ANOVA followed by Tukey test to assess differences among health condition (healthy or with denture stomatitis), materials and time point. Results: Non-albicans Candida species counts were higher in diseased patients with siliconebased denture liners ( p = 0.01). Denture stomatitis patients showed higher mutans streptococci counts after 7 days ( p = 0.0041). Conclusions: Longer biofilm formation time periods did not result in differences on biofilm composition. The denture liners evaluated in this study accumulate greater amount of biofilm, and therefore their use should be carefully planned. Clinical significance: The silicone-based denture liner tested should be used cautiously in patients with denture stomatitis as it showed increased non-albicans species counts, known to be difficult to treat. # 2013 Elsevier Ltd.

This study evaluated retrospectively the association among occlusal, periodontal and implant-prosthetic parameters and marginal bone loss (MBL) around implants and survival rate at 5.7 ±3.2 years of follow-up after prosthetic loading. Eighty-two patients received 164 external hexagon implants. After the standard healing period (3 to 6 months), the implants were restored with single-tooth or up to three splinted crowns. All patients were followed according to a strict maintenance program with regular recalls and clinically evaluated by a calibrated examiner. The MBL measurements taken from standardized radiographs made at permanent crown placement (baseline) and after the last evaluation were calculated considering occlusal, periodontal and implant-prosthetic parameters. Veneer fractures and abutment loosening were not considered failure. Two implants failed during the follow-up period, resulting in a survival rate of 98.8%. Cox regression analyses showed MBL associated with non-working side contacts (p=0.047), inadequate anterior guidance (p=0.001), lateral group guidance involving teeth and implants (p=0.015), periimplant plaque index (p=0.035), prosthetic design (p=0.030) and retention (p=0.006). Inadequate occlusal pattern guide, presence of visible plaque, and cemented and splinted implant-supported restoration were associated with greater MBL around the implant. Resumo Este estudo avaliou retrospectivamente a associação entre os parâmetros oclusais, periodontais e implante-protéticos e perda óssea marginal (POM) ao redor de implantes e taxa de sobrevivência, em 5,7 ± 3,2 anos de acompanhamento após o carregamento protético. Oitenta e dois pacientes receberam um total de 164 implantes com hexágono externo. Após o período de cicatrização (3 à 6 meses), os implantes foram restaurados com coroa unitária ou até três coroas ferulizadas. Todos os pacientes seguiram um programa de manutenção rigoroso, com consultas regulares e avaliações clinicas realizadas por um examinador calibrado. As medições de POM obtidas de radiografias padronizadas realizadas na colocação da coroa permanente (baseline) e após a última avaliação foram calculadas considerando os parâmetros oclusais, periodontais e àqueles relacionados ao implante e prótese. Fratura na cerâmica de cobertura e afrouxamento do pilar não foram considerados falhas. Dois implantes falharam durante o período de acompanhamento, resultando em uma taxa de sobrevivência de 98,8%.A análise de regressão de Cox mostrou POM associado com contatos no lado de balanceio (p= 0,047), inadequada guia anterior (p=0,001), guia lateral em grupo envolvendo dentes e implantes (p=0,015), índice de placa visível em torno do implante (p=0,035), tipo de prótese (p= 0,030) e retenção (p=0,006). Guia de padrão oclusal inadequado, presença de placa visível e restaurações implanto-suportadas cimentadas e ferulizadas resultaram em maior POM ao redor do implante.

Background In the sera of liver, colorectal and prostate cancer patients, several biomarkers may be detected as IgM immune complexes. To determine whether the presence of immune complexes was correlated to an increase of IgMs, we measured the IgM content in the sera of patients with hepatocellular carcinoma (HCC) and cirrhosis, and evaluated the occurrence of des-gamma-carboxy prothrombin (DCP) as immune complexes (DCP-IgM) compared to the levels of DCP and alpha-fetoprotein (AFP). Patients and methods Serum samples from 31 patients with cirrhosis, 33 untreated HCC patients diagnosed by ultrasound, computed tomography and/or magnetic resonance and confirmed by histopathology, when indicated, and 30 healthy controls were analysed. Concentrations of IgM and DCP-IgM were determined by ELISAs. Results Circulating IgM in patients with HCC (median level = 1·79 mg mL−1) and cirrhosis (1·09 mg mL−1) were not significantly different (P = 0·1376) while DCP-IgM were significantly higher in HCC patients (median level = 2171·2 AU mL−1) than in those with cirrhosis (1152 AU mL−1, P = 0·0047). No correlation was found between DCP-IgM and IgM in HCC (r = 0·227) and cirrhosis patients (r = 0·475). DPC-IgM was positive in 55% (18/33) of HCC patients and in 26% (8/31) of cirrhosis patients compared to 39% and 26% for DCP and 48% and 13% for AFP. DCP-IgM, DCP and AFP tests had 100% specificity in healthy controls. Conclusions DCP-IgM in HCC patients was not associated with an increase in IgM concentration. DCP-IgM was more frequently detected in HCC patients than DCP and AFP, strengthening the diagnostic role of IgM immune complexes for liver cancer.

Objectives: The aims of this study were to evaluate the antimicrobial activity and effect of denture cleansers and the phytotherapic Plantago australis Lam. on mechanical properties of two resilient denture liners. Materials and method: Samples of acrylic and silicone based materials were submitted to biofilm formation using 24-well polystyrene cell tissue culture plates to form C. albicans biofilm for 1, 7 and 14 days. The specimens were subjected to the following treatments: distilled water, 0.5% sodium hypochlorite, sodium perborate and Plantago australis Lam. Counts of Candida were calculated and the results expressed in colony forming units (CFU)/mm2. The following analyses were performed: sorption and solubility, surface roughness and scanning electron microscopy (SEM). Results: Three-way ANOVA showed a statistically significant difference between materials (p

Objective: The oral environment is subject to biofilm accumulation and cariogenic challenge, and few studies exist on the effect of these factors on the bond strength of adhesive systems. The aim of this study was to test if the exposure of adhesive interfaces to cariogenic challenge under biofilm accumulation could promote higher degradation than the exposure to biofilm accumulation alone. Material And Methods: Five molars were ground until exposure of medium dentin and then restored (Single Bond 2 and Z250 3M ESPE). The tooth/resin sets were cut to obtain beam-shaped specimens, which were distributed according to the aging conditions (n=20): water for 24 h (control); biofilm under cariogenic challenge for 3, 5 or 10 days; biofilm without cariogenic challenge for 10 days; and water for 3 months. Microcosm biofilms were formed from human saliva and grown in a saliva analogue medium, supplemented or not with sucrose to promote cariogenic challenge. Specimens were tested for microtensile bond strength, and failure modes were classified using light microscopy. Bond strength data were analyzed using ANOVA and failure modes were analyzed using ANOVA on ranks (α=0.05). Results: No significant differences in bond strength were detected among the aging methods (P=0.248). The aging period was associated with an increase in the frequency of adhesive failures for the groups aged for 10 days or longer (P

The present clinical report describes the prosthodontic management for a patient with uncontrolled bleeding and diabetes mellitus treated with a maxillary complete denture and a mandibular partial fixed dental prosthesis designed to interface with a removable cast framework partial denture retained by 2 ERA attachments. This approach was undertaken to improve both retention and stability of the distal extension Kennedy Class I removable partial denture. The rehabilitation provided better anterior esthetics than if treated with a conventional clasp retained removable partial denture, by employing a simple, practical design and offering a significant biomechanical advantages, restoring both oral health and function. Thus, this treatment modality, involving an ERA system and transfixation in fixed crowns, is an effective treatment and can be indicated as a clinical alternative for edentulous and partially edentulous patients with systemic disorders or for patients in economic situations that might preclude implant-based rehabilitation.

Os autores avaliaram o efeito dos métodos de polimerização sobre a movimentação dental linear em prótese totalsuperior. Vinte conjuntos modelo-base de prova de cera com dentes artificiais foram separados aleatoriamenteem dois grupos de dez elementos, recebendo os seguintes tratamentos experimentais: Grupo 1- Inclusão emmuflas metálicas com muralha de gesso-pedra e polimerização convencional em água. Grupo 2- Inclusão emmuflas de fibra de vidro com muralha de gesso pedra e polimerização com energia de microondas. As distânciasentre os dentes I-I, PM-PM, M-M, ID-MD e IE-ME foram mensuradas antes e depois da polimerização da basee os dados obtidos submetidos a ANOVA e ao teste de Tukey em nível de 5% de significância. Não houvediferença estatística significativa nas distâncias lineares transversais e ântero-posteriores entre os dentes.

Purpose: This is a case series report with up to five-year follow-up of preservation of remaining teeth used as retentive attachments to support an overdenture. Case Description: A valuable treatment to achieve immediate retention and stability was performed by using the patient’s remaining teeth with root-retained attachments combined with an overdenture. All overdentures were considered successful at the 5-year follow-up. Conclusion: Within the limitations of this case series, the use of short-coping and ball attachments to improve the retention and stability of overdentures is recommended. This treatment option is usually related to limited financial resources or to any health restraint.

Purpose: This is a case series report with up to five-year follow-up of preservation of remaining teeth used as retentive attachments to support an overdenture. Case Description: A valuable treatment to achieve immediate retention and stability was performed by using the patient’s remaining teeth with root-retained attachments combined with an overdenture. All overdentures were considered successful at the 5-year follow-up. Conclusion: Within the limitations of this case series, the use of short-coping and ball attachments to improve the retention and stability of overdentures is recommended. This treatment option is usually related to limited financial resources or to any health restraint. Objetivo: O presente estudo é uma série de casos com 5 anos de acompanhamento de preservação de remanescente dental usado como retentor para suporte de overdenture. Descrição do Caso: Um valioso tratamento para alcançar retenção e estabilidade imediata foi realizado utilizando remanescentes dentais com retentores radiculares combinados com overdentures. Todas overdentures foram consideradas satisfatórias ao final dos 5 anos. Conclusão: Dentro das limitações desta série de casos, o uso de copings curtos e retentores do tipo “bola” para aumentar a retenção e estabilidade de overdentures é recomendada. Esta opção de tratamento é usualmente relacionada com recursos financeiros limitados ou nenhuma restrição de saúde.