1. Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial
- Author
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Priyanka S. Sagar, Alexandra Munt, Sayanthooran Saravanabavan, Farnoosh Asghar Vahedi, James Elhindi, Beatrice Nguyen, Katrina Chau, David C. Harris, Vincent Lee, Kamal Sud, Nikki Wong, and Gopala K. Rangan
- Subjects
Polycystic kidney disease ,Beetroot juice ,Dietary interventions in hypertension ,Medicine (General) ,R5-920 - Abstract
Abstract Background In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice (BRJ) reduces blood pressure (BP) by increasing NO-mediated vasodilation. The aim of this double-blind, randomised, placebo-controlled study is to test the hypothesis that BRJ reduces systolic and diastolic clinic BP in hypertensive adults with ADPKD. Methods Participants with ADPKD and treated hypertension (n = 60) will be randomly allocated (1:1) to receive a daily dose of either nitrate-replete (400 mg nitrate/day) or nitrate-deplete BRJ for 4 weeks. The co-primary outcomes are change in mean systolic and diastolic clinic BP before and after 4 weeks of treatment with daily BRJ. Secondary outcomes are changes in daily home BP, urinary albumin to creatinine ratio, serum and salivary nitrate/nitrite levels and serum asymmetric dimethylarginine levels before and after 4 weeks of BRJ. Discussion The effect of BRJ in ADPKD has not been previously tested. BRJ is an accessible, natural dietary supplement that, if effective, will provide a novel adjunctive approach for treating hypertension in ADPKD. Trial registration ClinicalTrials.gov NCT05401409. Retrospectively registered on 27th May 2022.
- Published
- 2023
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