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Background: In 2016, three European scientific societies called for standardization to the “2222” as a European unique phone number in case of in-hospital emergencies. This study describes the management of in-hospital emergency calls in all French military training hospitals and aims to detail their original transition, for the first time in France, to the “2222”. Methods: An electronic standardized questionnaire was emailed to heads of rapid response teams in the eight French military training hospitals. Results: All participants answered the questionnaire (100%). The eight French military training hospitals had a specific procedure for management of in-hospital emergencies. Six hospitals already used a unique phone number for in-hospital emergencies, but none of them were using the 2222 in March 2019. Two hospitals still used several phone numbers for in-hospital emergencies, mainly due to historical and local arrangements. Rapid response teams included at least a physician and a nurse. There was a discussion to switch to “2222” as the unique phone number for in-hospital emergencies in two hospitals. In both, the discussions involved hospital executive officers, medical teams, rapid response teams and technical teams leading to a step-by-step transition. Finally, in October 2019, these two hospitals launched the “2222” procedure for in-hospital emergencies. Conclusion: This study found a large disparity in the eight French military training hospitals, concerning in-hospital emergency protocols. Two French military training hospitals launched the “2222” procedure for the first time in France. Further efforts are still needed to continue to promote the use of the 2222 as a European unique phone number for in-hospital emergencies.

La futaie de pin maritime du Massif des Landes de Gascogne fait l'objet d'une sylviculture dynamique ; les dommages occasionnés par les tempêtes Martin (1999) et Klaus (2009) puis par des ravageurs (scolytes) ont entrainé une forte diminution de la ressource en bois. Cela a accentué la demande de la filière forêt-bois aquitaine pour un suivi permanent, précis et spatialisé de celle-ci. L'étude Pinastéréo ouvre des perspectives nouvelles en la matière grâce au modèle numérique de surface (MNS) obtenu par corrélation d'images stéréoscopiques Pléiades. Sa combinaison avec le modèle numérique de terrain BD Alti® fournit le modèle de hauteur de canopée (MNHC). La précision des MNS et MNHC a été évaluée avec des mesures de référence (LiDAR aérien, placettes de levers dendrométriques) ; elle s'est avérée satisfaisante. Il est montré que la hauteur dominante des peuplements de pin maritime, leur volume aérien total et leur biomasse peuvent être modélisés à partir du MNHC. Une carte de la hauteur dominante a alors été produite sur un site de référence ; celle de la biomasse reste à faire. Les faibles incertitudes observées sur les estimations de hauteur et de volume sont très prometteurs pour une généralisation de la méthode au Massif landais ou même à d'autres futaies régulières résineuses.

Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a variety of diseases, STING has been a focus for drug discovery. Targeted protein degradation (TPD) has emerged as a promising pharmacology for targeting previously considered undruggable proteins by hijacking the cellular ubiquitin proteasome system (UPS) with small molecules. Here, we identify AK59 as a STING degrader leveraging HERC4, a HECT-domain E3 ligase. Additionally, our data reveals that AK59 is effective on the common pathological STING mutations, suggesting a potential clinical application of this mechanism. Thus, these findings introduce HERC4 to the fields of TPD and of compound-induced degradation of STING, suggesting potential therapeutic applications.