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1. Association Between Bio-Fermentation Derived Hyaluronic Acid and Healthcare Costs Following Knee Arthroplasty

Author

Nicholls M, Niazi F, Nelson WW, Lau E, Kurtz SM, and Ong KL

Subjects
bio-fermentation derived hyaluronic acid, healthcare costs, intra-articular hyaluronic acid, knee arthroplasty, readmissions, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Mathew Nicholls,1 Faizan Niazi,2 Winnie W Nelson,2 Edmund Lau,3 Steven M Kurtz,4 Kevin L Ong4 1Virginia Mason Orthopaedics and Sports Medicine, Seattle, WA, USA; 2Ferring Pharmaceuticals Inc, Parsippany, NJ, USA; 3Exponent, Inc, Menlo Park, CA, USA; 4Exponent, Inc, Philadelphia, PA, USACorrespondence: Kevin L Ong, Exponent, Inc, Philadelphia, PA, USA, Tel +1 215 594-8800, Email kong@exponent.comBackground: Limiting access to intra-articular knee injections, including hyaluronic acid (HA), has been advocated as a cost-containment measure in the treatment of knee osteoarthritis. The association between presurgical injections and post-surgical complications such as early periprosthetic joint infection and revision remained to be investigated. This study evaluated pre- and post-surgical costs and rates of post-surgical complications in knee arthroplasty (KA) patients with or without prior HA use.Methods: Commercial and Medicare Supplemental Claims Data (IBM MarketScan Research Databases) from January 1, 2012 to December 31, 2018 were used to identify unilateral KA patients. Those who completed a course of bio-fermentation derived HA (Bio-HA) as the first-line HA therapy comprised of the test group (n = 4091), while the control group did not use HA prior to KA (n = 118,659). Using multivariable regression with propensity score (PS) weighting, overall healthcare costs, readmission rates, and revision rates were assessed at six months following KA.Results: Healthcare costs following KA were significantly lower for the Bio-HA group ($10,021 ± $22,796) than No HA group ($12,724 ± $32,966; PS p < 0.001). Bio-HA patients had lower readmission rates (8.9% vs 14.0%; PS p < 0.001) and inpatient costs per readmitted patient ($43,846 ± $50,648 vs $50,533 ± $66,150; PS p = 0.005). There were no differences in revision rate for any reason (Bio-HA: 0.78% vs No HA: 0.67%; PS p = 0.361) and with PJI (Bio-HA: 0.42% vs No HA: 0.33%; PS p = 0.192). Costs in the six months up to and including the KA were similar for both groups (Bio-HA: $49,759 ± $40,363 vs No HA: $50,532 ± $43,183; PS p = 0.293).Conclusion: Bio-HA use prior to knee arthroplasty did not appear to increase overall healthcare costs in the six months before and after surgery. Allowing access to HA injections provides a non-surgical therapeutic option without increasing cost or risk of post-surgical complications.Keywords: bio-fermentation derived hyaluronic acid, healthcare costs, intra-articular hyaluronic acid, knee arthroplasty, readmissions

Published
2022

7. Precision requirements for space-based X CO 2 data

Author

Miller, C. E, Crisp, D., DeCola, P. L, Olsen, S. C, Randerson, J. T, Michalak, A. M, Alkhaled, A., Rayner, P., Jacob, D. J, Suntharalingam, P., Jones, D. B. A, Denning, A. S, Nicholls, M. E, Doney, S. C, Pawson, S., Boesch, H., Connor, B. J, Fung, I. Y, O'Brien, D., Salawitch, R. J, Sander, S. P, Sen, B., Tans, P., Toon, G. C, Wennberg, P. O, Wofsy, S. C, Yung, Y. L, and Law, R. M

Subjects
atmospheric composition, carbon dioxide, mathematical models, uncertainty analysis, assessment method, carbon dioxide, carbon flux, precision, sampling, simulation, spatiotemporal analysis
Abstract

Precision requirements are determined for space-based column-averaged CO2 dry air mole fraction data. These requirements result from an assessment of spatial and temporal gradients in the relationship between precision and surface CO2 flux uncertainties inferred from inversions of the data, and the effects of biases on the fidelity of CO2 flux inversions. Observational system simulation experiments and synthesis inversion modeling demonstrate that the Orbiting Carbon Observatory mission design and sampling strategy provide the means to achieve these data precision requirements.

Published
2007

8. Development and performance characterisation of a novel gas-liquid contacting stage

Author

Nicholls, M. P.

Subjects
660
Abstract

This project has been concerned with the development and performance testing of a novel gas liquid contacting stage with potential for use in stage-wise mass transfer processes such as gas absorption or distillation. The contactor employs the principal of co-current flow of the two phases within each stage whilst maintaining counter-current flow over a column consisting of many such stages. Each stage consists of an entraining section, in which the liquid is entrained into the up flowing gas, and a disentraining section situated above this in which the liquid droplets are separated from the gas, collected and passed to the entraining section of the stage beneath. The primary advantage of this contactor over conventional equipment such as packed or tray columns is the much higher allowable gas velocity, which would allow narrower columns to be constructed for a given duty.

Published
1999

11. William Shakespeare: King Lear

Author

Barnard, T, Hayes, K, Nicholls, M, Barnard, T, Hayes, K, and Nicholls, M

Abstract

Books are central to the work of Jean-Luc Godard, avid reader of pulp fiction and philosophical treatises, classical drama and modernist novels, scientific tomes and Maoist doctrine, comic books and volumes of art history.

Published
2023

13. Who Saw Her Die? Unfixing the Danse sacrale in Le Sacre du printemps

Author

Nicholls, M and Nicholls, M

Abstract

This article focuses on the last moments of Le Sacre du printemps, which opened in Paris on 29 May 1913 at the Théâtre des Champs-Élysées. Concentrating on the discourse of the creative practice that brought these moments into being, it seeks to add to our understanding of Le Sacre from the evidence of those most intimately involved with this first production. Analysis of Le Sacre demonstrates the equal viability of a great variety of readings of the work. Such readings are enabled by analysis, which regards any aspect of a creative work and its best interpretation as happily unfixed and unstable. It has sometimes been accepted that the job of critics and theorists is to fix interpretations of creative works and to demonstrate conveniently closed theses about them. Creative artists are not always willing to join their critical colleagues. This was certainly the case with Le Sacre. By reading the final seven seconds of its Danse sacrale through the accounts of the work’s primary creators – composer Igor Stravinsky, designer Nicholas Roerich, and their creative intimates – this article highlights an engrossing instability of intention and interpretation. It questions the idea that Le Sacre is a sacrificial ritual in the light of how Stravinsky himself considered his work in terms of coronation and consecration.

Published
2023

24. Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation

Author

Ying Ying Wong, Dinh Td, Darryl L. Russell, Emery A, Barbara Nicol, Smith Km, Humphrey H-C Yao, James Breen, Nicholls M, Simon Barry, and Rebecca L. Robker

Subjects
Gene isoform, endocrine system, Progesterone receptor A, media_common.quotation_subject, Promoter, Biology, Chromatin, Cell biology, Progesterone receptor, Transcriptional regulation, skin and connective tissue diseases, Transcription factor, Ovulation, hormones, hormone substitutes, and hormone antagonists, media_common
Abstract

SummaryProgesterone receptor (PGR) plays diverse roles in reproductive tissues and thus coordinates mammalian fertility. In the ovary, acutely induced PGR is the key determinant of ovulation through transcriptional control of a unique set of genes that culminates in follicle rupture. However, the molecular mechanisms for PGR’s specialised function in ovulation is poorly understood. To address this, we assembled a detailed genomic profile of PGR action through combined ATAC-seq, RNA-seq and ChIP-seq analysis in wildtype and isoform-specific PGR null mice. We demonstrated the unique action of PGR-A isoform in the ovary through a transcriptional complex involving physical interaction with RUNX and JUN/FOS transcription factors. The assembly of this unique complex directs targeting of PGR binding to proximal promoter regions and enables chromatin accessibility, leading to ovulatory gene induction. This PGR signalling mechanism is specific to ovulation and provides potential targets for infertility treatments as well as new contraceptives that block ovulation.

Published
2021
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29. New Government, Same Narrow Vision

Author

McFarlane, H., Madhok, Rajan, Nicholls, M. Gary, Richards, A. Mark, Moller, Peter W., Elliott, John M., Begg, E. J., and Padwell, Alan

Published
1998

30. The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

Author

Azzoni, E, Frontera, V, Anselmi, G, Rode, C, James, C, Deltcheva, E, Demian, A, Brown, J, Barone, C, Patelli, A, Harman, J, Nicholls, M, Conway, S, Morrissey, E, Jacobsen, S, Sparrow, D, Harris, A, Enver, T, de Bruijn, M, Azzoni, Emanuele, Frontera, Vincent, Anselmi, Giorgio, Rode, Christina, James, Chela, Deltcheva, Elitza M, Demian, Atanasiu S, Brown, John, Barone, Cristiana, Patelli, Arianna, Harman, Joe R, Nicholls, Matthew, Conway, Simon J, Morrissey, Edward, Jacobsen, Sten Eirik W, Sparrow, Duncan B, Harris, Adrian L, Enver, Tariq, de Bruijn, Marella F T R, Azzoni, E, Frontera, V, Anselmi, G, Rode, C, James, C, Deltcheva, E, Demian, A, Brown, J, Barone, C, Patelli, A, Harman, J, Nicholls, M, Conway, S, Morrissey, E, Jacobsen, S, Sparrow, D, Harris, A, Enver, T, de Bruijn, M, Azzoni, Emanuele, Frontera, Vincent, Anselmi, Giorgio, Rode, Christina, James, Chela, Deltcheva, Elitza M, Demian, Atanasiu S, Brown, John, Barone, Cristiana, Patelli, Arianna, Harman, Joe R, Nicholls, Matthew, Conway, Simon J, Morrissey, Edward, Jacobsen, Sten Eirik W, Sparrow, Duncan B, Harris, Adrian L, Enver, Tariq, and de Bruijn, Marella F T R

Abstract

Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1−/− mouse embryos devoid of circulation the HSC lineage develops until the phenotypic pro-HSC stage. However, these cells reside in an abnormal microenvironment, fail to activate the hematopoietic program downstream of Runx1, and are functionally impaired. Single-cell transcriptomics shows that during the endothelial-to-hematopoietic transition, Ncx1−/− cells fail to undergo a glycolysis to oxidative phosphorylation metabolic switch present in wild-type cells. Interestingly, experimental activation of glycolysis results in decreased intraembryonic hematopoiesis. Our results suggest that the onset of circulation triggers metabolic changes that allow HSC generation to proceed.

Published
2021

31. New Zealand Priority Criteria Project

Author

Mordue, Alan, Parkin, David W., Elliott, John, Doogue, Matthew, Crozier, Ian, Smyth, David, Richards, A. Mark, Nicholls, M. Gary, and Ikram, Hamid

Published
1997

32. Effect of B-type natriuretic peptide-guided treatment of chronic heart failure on total mortality and hospitalization: an individual patient meta-analysis

Author

Troughton, Richard W., Frampton, Christopher M., Brunner-La Rocca, Hans-Peter, Pfisterer, Matthias, Eurlings, Luc W.M., Erntell, Hans, Persson, Hans, OʼConnor, Christopher M., Moertl, Deddo, Karlström, Patric, Dahlström, Ulf, Gaggin, Hanna K., Januzzi, James L., Berger, Rudolf, Richards, A. Mark, Pinto, Yigal M., and Nicholls, M. Gary

Published
2014
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34. The contribution of XANES spectroscopy to tribology (1)

Author

Nicholls, M., Najman, M.N., Zhang, Z., Kasrai, M., Norton, P.R., and Gilbert, P.U.P.A.

Subjects
Microscope and microscopy -- Research -- Methods, X-ray spectroscopy -- Methods -- Research, Tribology -- Research -- Methods, Chemistry, Research, Properties, Methods
Abstract

Abstract: X-ray absorption near edge structure spectroscopy (XANES) analysis has been routinely used to study the complex chemical interactions between additives in engine oil and metallic surfaces during high-temperature and [...]

Published
2007

35. Sir Bernard Katz

Author

Nicholls, M, Grassi, G, Nicholls, Mark, Grassi, Guido, Nicholls, M, Grassi, G, Nicholls, Mark, and Grassi, Guido

Published
2020

46. Measurements on the growth of gaseous ionization at ultra high frequencies

Author

Nicholls, M. J.

Abstract

An apparatus has been built to study ionization by collision in a gas under ultra high frequency fields and especially the conditions covering the transition to the conducting state. The u.h.f. field is developed between two Rogowski profiled electrodes incorporated into a tuned quarter wave transmission line which is loosely coupled to the main oscillator. The u.h.f. field has a frequency of 105 Mc/sec. and its magnitude is measured by its effect on the frequency of oscillation of a small metal disc suspended in the gap. This instrument is used as a step-over so that a rectifying circuit loosely coupled to the transmission line can be calibrated. The disc can be removed from the gap during the experiments. Electrons are emitted from a thermionic cathode situated inside one of the electrodes and diffuse out into the gap through small holes in the electrode shell where they are moved across the gap by a small unidirectional field. The large u.h.f. field is superimposed on this field so that the electrons acquire enough energy to ionize the gas by collision; the resulting electron current to the far electrode is measured by a galvanometer. With this arrangement the amplification resulting from collision ionization can "be measured and its dependence on the lifetime of the electron in the gap can be studied. The measurements can. be carried right up to breakdown conditions, and the results can be expressed in terms of the number of ionizing collisions per second in the life of one electron, a coefficient closely related to Tosnsend's a. It is shown that the lifetime of the electrons not only depends on the drift under the direct field but also on the process of diffusion out of the gap and two methods of evaluating it are given. Although only preliminary results have been obtained these are sufficient to indicate that a useful contribution to ionization studies can be made by investigations with this apparatus.

Published
1959

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