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2. Growth Hormone Receptor Antagonist Markedly Improves Gemcitabine Response in a Mouse Xenograft Model of Human Pancreatic Cancer.

Author

Basu, Reetobrata, Kulkarni, Prateek, Swegan, Deborah, Duran-Ortiz, Silvana, Ahmad, Arshad, Caggiano, Lydia J., Davis, Emily, Walsh, Christopher, Brenya, Edward, Koshal, Adeel, Brody, Rich, Sandbhor, Uday, Neggers, Sebastian J. C. M. M., and Kopchick, John J.

Subjects
SOMATOTROPIN receptors, PITUITARY dwarfism, HORMONE antagonists, PANCREATIC cancer, TREATMENT effectiveness, LABORATORY mice, GEMCITABINE
Abstract

Chemotherapy treatment against pancreatic ductal adenocarcinoma (PDAC) is thwarted by tumoral activation of multiple therapy resistance pathways. The growth hormone (GH)–GH receptor (GHR) pair is a covert driver of multimodal therapy resistance in cancer and is overexpressed in PDAC tumors, yet the therapeutic potential of targeting the same has not been explored. Here, we report that GHR expression is a negative prognostic factor in patients with PDAC. Combinations of gemcitabine with different GHR antagonists (GHRAs) markedly improve therapeutic outcomes in nude mice xenografts. Employing cultured cells, mouse xenografts, and analyses of the human PDAC transcriptome, we identified that attenuation of the multidrug transporter and epithelial-to-mesenchymal transition programs in the tumors underlie the observed augmentation of chemotherapy efficacy by GHRAs. Moreover, in human PDAC patients, GHR expression strongly correlates with a gene signature of tumor promotion and immune evasion, which corroborate with that in syngeneic tumors in wild-type vs. GH transgenic mice. Overall, we found that GH action in PDAC promoted a therapy-refractory gene signature in vivo, which can be effectively attenuated by GHR antagonism. Our results collectively present a proof of concept toward considering GHR antagonists to improve chemotherapeutic outcomes in the highly chemoresistant PDAC. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Leptin Increase During Dexamethasone and Its Association With Hunger and Fat in Pediatric Acute Lymphoblastic Leukemia

Author

van Hulst, Annelienke M, primary, Verwaaijen, Emma J, additional, van den Berg, Sjoerd A A, additional, van Litsenburg, Raphaële R L, additional, Grootenhuis, Martha A, additional, Fiocco, Marta, additional, Neggers, Sebastian J C M M, additional, van den Heuvel-Eibrink, Marry M, additional, and van den Akker, Erica L T, additional

Published
2023
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6. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study

Author

van Atteveld, Jenneke E, primary, de Winter, Demi T C, additional, Pluimakers, Vincent G, additional, Fiocco, Marta, additional, Nievelstein, Rutger A J, additional, Hobbelink, Monique G G, additional, Kremer, Leontien C M, additional, Grootenhuis, Martha A, additional, Maurice-Stam, Heleen, additional, Tissing, Wim J E, additional, de Vries, Andrica C H, additional, Loonen, Jacqueline J, additional, van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J H, additional, Pluijm, Saskia M F, additional, van der Heiden-van der Loo, Margriet, additional, Versluijs, A Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M, additional, Hoefer, Imo, additional, van den Berg, Sjoerd A A, additional, den Hartogh, Jaap, additional, Hoeijmakers, Jan H J, additional, Neggers, Sebastian J C M M, additional, and van den Heuvel-Eibrink, Marry M, additional

Published
2023
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7. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER):a cross-sectional study

Author

van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, van den Heuvel-Eibrink, Marry M, van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, and van den Heuvel-Eibrink, Marry M

Abstract

BACKGROUND: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001.METHODS: Eligible individuals (alive at the time of study, living in the Netherlands, age 18-45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements.FINDINGS: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18-45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0-22·7), frailty was 7·4% (6·0-9·0), and sarcopenia was 4·4% (3·5-5·6). In the models for pre-frai

Published
2023

8. Long term safety of growth hormone replacement therapy in survivors of cancer and tumors of the pituitary region

Author

Cancer, MS Radiotherapie, Speerpunt, Child Health, Zorg en O&O, Bolier, Melissa, Van der Lelij, Aart-Jan, Maxima, Princess, van den Heuvel-Eibrink, Marry M, Neggers, Sebastian J C M M, Cancer, MS Radiotherapie, Speerpunt, Child Health, Zorg en O&O, Bolier, Melissa, Van der Lelij, Aart-Jan, Maxima, Princess, van den Heuvel-Eibrink, Marry M, and Neggers, Sebastian J C M M

Published
2023

9. Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Clasen, Nikita H Z, van der Perk, M E Madeleine, Neggers, Sebastian J C M M, Bos, Annelies M E, van den Heuvel-Eibrink, Marry M, Speerpunt, Zorg en O&O, Cancer, Child Health, Clasen, Nikita H Z, van der Perk, M E Madeleine, Neggers, Sebastian J C M M, Bos, Annelies M E, and van den Heuvel-Eibrink, Marry M

Published
2023

12. Prevalence and Risk Factors for Hyposalivation and Xerostomia in Childhood Cancer Survivors Following Different Treatment Modalities—A Dutch Childhood Cancer Survivor Study Late Effects 2 Clinical Study (DCCSS LATER 2)

Author

Stolze, Juliette, primary, Teepen, Jop C., additional, Raber-Durlacher, Judith E., additional, Loonen, Jacqueline J., additional, Kok, Judith L., additional, Tissing, Wim J. E., additional, de Vries, Andrica C. H., additional, Neggers, Sebastian J. C. M. M., additional, van Dulmen-den Broeder, Eline, additional, van den Heuvel-Eibrink, Marry M., additional, van der Pal, Helena J. H., additional, Versluys, A. Birgitta, additional, van der Heiden-van der Loo, Margriet, additional, Louwerens, Marloes, additional, Kremer, Leontien C. M., additional, Brand, Henk S., additional, and Bresters, Dorine, additional

Published
2022
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13. The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study

Author

Penson, Adriaan, primary, Walraven, Iris, additional, Bronkhorst, Ewald, additional, Maurice-Stam, Heleen, additional, Grootenhuis, Martha A., additional, Van der Heiden-van der Loo, Margriet, additional, Tissing, Wim J. E., additional, Van der Pal, Helena J. H., additional, De Vries, Andrica C. H., additional, Bresters, Dorine, additional, Ronckers, Cécile, additional, Van den Heuvel, Marry M., additional, Neggers, Sebastian J. C. M. M., additional, Versluys, Birgitta A. B., additional, Louwerens, Marloes, additional, Pluijm, Saskia M. F., additional, Kremer, Leontien C. M., additional, Blijlevens, Nicole, additional, Van Dulmen-den Broeder, Eline, additional, Knoop, Hans, additional, and Loonen, Jacqueline, additional

Published
2022
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15. Safety of growth hormone replacement in survivors of cancer and intra-cranial and pituitary tumours - A consensus statement

Author

Endocrinologie patientenzorg, Brain, Child Health, Cancer, Boguszewski, Margaret C S, Boguszewski, Cesar L, Chemaitilly, Wassim, Cohen, Laurie E, Gebauer, Judith, Higham, Claire, Hoffman, Andrew R, Polak, Michel, Yuen, Kevin C J, Alos, Nathalie, Antal, Zoltan, Bidlingmaier, Martin, Biller, Beverly M K, Brabant, Georg, Choong, Catherine S Y, Cianfarani, Stefano, Clayton, Peter E, Coutant, Regis, Cardoso-Demartini, Adriane A, Fernandez, Alberto, Grimberg, Adda, Gudmundsson, Kolbeinn, Guevara-Aquirre, Jamie, Ho, Ken K Y, Horikawa, Reiko, Isidori, Andrea M, Jorgensen, Jens Otto Lunde, Kamenicky, Peter, Karavitaki, Niki, Kopchick, John J, Lodish, Maya, Luo, Xiao-Ping, McCormack, Ann I, Meacham, Lillian, Melmed, Shlomo, Sogol Mostoufi-Moab, Sogol, Müller, Hermann L, Neggers, Sebastian J C M M, Aguiar-Oliveira, Manuel H, Ozono, Keiichi, Pennisi, Patricia A, Popovic, Vera, Radovick, Sally, Savendahl, Lars, Touraine, Philippe, van Santen, Hanneke M, Johannsson, Gudmundur, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Boguszewski, Margaret C S, Boguszewski, Cesar L, Chemaitilly, Wassim, Cohen, Laurie E, Gebauer, Judith, Higham, Claire, Hoffman, Andrew R, Polak, Michel, Yuen, Kevin C J, Alos, Nathalie, Antal, Zoltan, Bidlingmaier, Martin, Biller, Beverly M K, Brabant, Georg, Choong, Catherine S Y, Cianfarani, Stefano, Clayton, Peter E, Coutant, Regis, Cardoso-Demartini, Adriane A, Fernandez, Alberto, Grimberg, Adda, Gudmundsson, Kolbeinn, Guevara-Aquirre, Jamie, Ho, Ken K Y, Horikawa, Reiko, Isidori, Andrea M, Jorgensen, Jens Otto Lunde, Kamenicky, Peter, Karavitaki, Niki, Kopchick, John J, Lodish, Maya, Luo, Xiao-Ping, McCormack, Ann I, Meacham, Lillian, Melmed, Shlomo, Sogol Mostoufi-Moab, Sogol, Müller, Hermann L, Neggers, Sebastian J C M M, Aguiar-Oliveira, Manuel H, Ozono, Keiichi, Pennisi, Patricia A, Popovic, Vera, Radovick, Sally, Savendahl, Lars, Touraine, Philippe, van Santen, Hanneke M, and Johannsson, Gudmundur

Published
2022

16. Dissecting the In Vitro Efficacy of Octreotide and Cabergoline in GH- and GH/PRL-Secreting Pituitary Tumors.

Author

Gatto, Federico, Feelders, Richard A., van Koetsveld, Peter M., Dogan, Fadime, Neggers, Sebastian J. C. M. M., van der Lelij, Aart-Jan, Amarù, Jessica, Ferone, Diego, and Hofland, Leo J.

Subjects
OCTREOTIDE acetate, PITUITARY tumors, SOMATOSTATIN receptors
Abstract

Context: Cabergoline (CAB) is an off-label medical therapy for acromegaly, overshadowed by first-generation somatostatin receptor ligands, eg, octreotide (OCT). Objective: This was a head-to-head comparison between OCT and CAB in inhibiting growth hormone (GH) secretion in primary cultures of GH and GH/prolactin (PRL)-secreting tumors; we also investigated the role of somatostatin (SST) and dopamine type 2 (D2R) receptor expression. Methods: We evaluated the antisecretory effect of OCT and CAB, together with receptor mRNA expression, in 23 tumor cultures obtained from acromegaly patients referred to the Erasmus Medical Center (Rotterdam, The Netherlands). GH concentrations in cell culture media were determined after 72-hour OCT and CAB treatment (10 nM). Results: OCT showed a slightly higher efficacy compared with CAB (GH decrease −39.5% vs −32.5%, P=0.079). The effect of the 2 drugs was superimposable in GH/PRL co-secreting tumors (−42.1% vs −44.8%), where SST1 and D2R had a higher expression compared with the pure GH secreting tumors (P=0.020 and P=0.026). OCT was more effective than CAB in 8/23 cultures, while CAB was more effective than OCT in 3/23 (CAB+ group). In CAB+ tumors, SST1 expression was higher compared with the other groups (P=0.034). At receiver operating characteristic (ROC) curve analysis, SST1 and D2R discriminated between GH and GH/PRL co-secretion (AUC 0.856, P=0.013; AUC 0.822, P=0.024). SST1 was the best predictor of CAB response (≥50% GH reduction, AUC 0.913, P=0.006; 80% sensitivity, 94% specificity). Conclusion: OCT is 5% to 10% more effective than CAB in vitro. SST1 mRNA expression can represent a reliable marker of GH/PRL co-secreting tumors showing a preferential response to CAB treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Experiences of Female Childhood Cancer Patients and Survivors Regarding Information and Counselling on Gonadotoxicity Risk and Fertility Preservation at Diagnosis: A Systematic Review.

Author

Clasen, Nikita H. Z., van der Perk, M. E. Madeleine, Neggers, Sebastian J. C. M. M., Bos, Annelies M. E., and van den Heuvel-Eibrink, Marry M.

Subjects
CANCER patient psychology, ONLINE information services, COUNSELING, MEDICAL information storage & retrieval systems, SYSTEMATIC reviews, PATIENT satisfaction, TUMORS in children, PATIENTS' attitudes, RISK assessment, INFERTILITY, PSYCHOLOGY of women, HEALTH, INFORMATION resources, OVARIAN diseases, FERTILITY preservation, COMMUNICATION, MEDLINE, PATIENT-professional relations, CANCER patient medical care, DISEASE risk factors, DISEASE complications
Abstract

Simple Summary: Due to the significant increase in overall survival rates of childhood cancer, more awareness has been raised for the long-term consequences of treatment, including infertility. Currently, patients and their families are offered information regarding the risk of gonadal damage by paediatric oncologists and fertility counselling by fertility specialists regarding fertility preservation. However, the experiences of childhood cancer patients with oncofertility care are underreported. The available evidence reported in this review shows that female patients and survivors are variably satisfied with fertility information and report challenges in communication. They prefer to receive general information at diagnosis and detailed information later. Regrets are reported after refusal of fertility preservation. Patients and survivors are concerned about future children's health, effect on relationships and lack of control over fertility. With the results from this review, (international) standards for information for paediatric cancer patients and families may be developed to improve fertility information and counselling for current and future childhood cancer patients and survivors. Background: Childhood cancer patients and their families are increasingly offered oncofertility care including information regarding their risk of gonadal damage by paediatric oncologists, fertility counselling by fertility specialists and fertility preservation options. However, experiences regarding oncofertility care are underreported. We aimed to summarize the available evidence of experiences of female childhood cancer patients and survivors regarding oncofertility care. Methods: Manuscripts were systematically identified using the PubMed and Embase database. From, respectively, 1256 and 3857 manuscripts, 7 articles were included and assessed, including risk of bias assessment. Outcome measures included data describing experiences of female childhood cancer patients and survivors, regarding fertility information, counselling and/or preservation. Results: Female patients and survivors are variably satisfied with fertility information, report challenges in communication with healthcare professionals and prefer to receive general information at diagnosis and detailed fertility information later. Regrets after fertility counselling are underreported, but are associated with refusing fertility preservation. Lastly, regardless of counselling, female patients and survivors report fertility concerns about their future children's health and effect on relationships. Conclusion: Currently, the satisfaction with oncofertility care varies and female patients or survivors report regrets and concerns regardless of receiving fertility information or counselling. These results may help to improve the content of fertility information, communication skills of healthcare professionals and timing of counselling. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Questionnaire‐ and linkage‐based outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER study part 1.

Author

Teepen, Jop C., Kok, Judith L., Feijen, Elizabeth A. M., Loonen, Jacqueline J., van den Heuvel‐Eibrink, Marry M., van der Pal, Helena J., Tissing, Wim J. E., Bresters, Dorine, Versluys, Birgitta, Grootenhuis, Martha A., Louwerens, Marloes, Neggers, Sebastian J. C. M. M., van Santen, Hanneke M., de Vries, Andrica, Janssens, Geert O., den Hartogh, Jaap G., van Leeuwen, Flora E., Hollema, Nynke, Streefkerk, Nina, and Kilsdonk, Ellen

Subjects
CHILDHOOD cancer, CANCER survivors, MEDICAL registries, MEDICAL care use, PEDIATRIC oncology, CANCER fatigue
Abstract

Background: Childhood cancer survivors are at risk for developing long‐term adverse health outcomes. To identify the risk of and risk factors for specific health outcomes, well‐established cohorts are needed with detailed information on childhood cancer diagnosis, treatment, and health outcomes. We describe the design, methodology, characteristics, and data availability of the Dutch Childhood Cancer Survivor Study LATER cohort (1963–2001) part 1; questionnaire and linkage studies. Methods: The LATER cohort includes 5‐year childhood cancer survivors, diagnosed in the period 1963–2001, and before the age of 18 in any of the seven former pediatric oncology centers in the Netherlands. Information on health outcomes from survivors and invited siblings of survivors was collected by questionnaires and linkages to medical registries. Results: In total, 6165 survivors were included in the LATER cohort. Extensive data on diagnosis and treatment have been collected. Information on a variety of health outcomes has been ascertained by the LATER questionnaire study and linkages with several registries for subsequent tumors, health care use, and hospitalizations. Conclusion: Research with data of the LATER cohort will provide new insights into risks of and risk factors for long‐term health outcomes. This can enhance risk stratification for childhood cancer survivors and inform surveillance guidelines and development of interventions to prevent (the impact of) long‐term adverse health outcomes. The data collected will be a solid baseline foundation for future follow‐up studies. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors

Author

van Iersel, Laura, primary, Mulder, Renee L, additional, Denzer, Christian, additional, Cohen, Laurie E, additional, Spoudeas, Helen A, additional, Meacham, Lillian R, additional, Sugden, Elaine, additional, Schouten-van Meeteren, Antoinette Y N, additional, Hoving, Eelco W, additional, Packer, Roger J, additional, Armstrong, Gregory T, additional, Mostoufi-Moab, Sogol, additional, Stades, Aline M, additional, van Vuurden, Dannis, additional, Janssens, Geert O, additional, Thomas-Teinturier, Cécile, additional, Murray, Robert D, additional, Di Iorgi, Natascia, additional, Neggers, Sebastian J C M M, additional, Thompson, Joel, additional, Toogood, Andrew A, additional, Gleeson, Helena, additional, Follin, Cecilia, additional, Bardi, Edit, additional, Torno, Lilibeth, additional, Patterson, Briana, additional, Morsellino, Vera, additional, Sommer, Grit, additional, Clement, Sarah C, additional, Srivastava, Deokumar, additional, Kiserud, Cecilie E, additional, Fernandez, Alberto, additional, Scheinemann, Katrin, additional, Raman, Sripriya, additional, Yuen, Kevin C J, additional, Wallace, W Hamish, additional, Constine, Louis S, additional, Skinner, Roderick, additional, Hudson, Melissa M, additional, Kremer, Leontien C M, additional, Chemaitilly, Wassim, additional, and van Santen, Hanneke M, additional

Published
2021
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22. Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors.

Author

Iersel, Laura van, Mulder, Renee L, Denzer, Christian, Cohen, Laurie E, Spoudeas, Helen A, Meacham, Lillian R, Sugden, Elaine, Meeteren, Antoinette Y N Schouten-van, Hoving, Eelco W, Packer, Roger J, Armstrong, Gregory T, Mostoufi-Moab, Sogol, Stades, Aline M, Vuurden, Dannis van, Janssens, Geert O, Thomas-Teinturier, Cécile, Murray, Robert D, Iorgi, Natascia Di, Neggers, Sebastian J C M M, and Thompson, Joel

Subjects
CANCER survivors, CHILDHOOD cancer, HYPOTHALAMIC-pituitary-adrenal axis
Abstract

Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG surveillance recommendations for premature ovarian insufficiency, gonadotoxicity in males, fertility preservation, and thyroid cancer are summarized. For hypothalamic-pituitary (HP) dysfunction, new surveillance recommendations were formulated by a guideline panel consisting of 42 interdisciplinary international experts. A systematic literature search was performed in MEDLINE (through PubMed) for clinically relevant questions concerning HP dysfunction. Literature was screened for eligibility. Recommendations were formulated by drawing conclusions from quality assessment of all evidence, considering the potential benefits of early detection and appropriate management. Healthcare providers should be aware that CAYA cancer survivors have an increased risk for endocrine disorders, including HP dysfunction. Regular surveillance with clinical history, anthropomorphic measures, physical examination, and laboratory measurements is recommended in at-risk survivors. When endocrine disorders are suspected, healthcare providers should proceed with timely referrals to specialized services. These international evidence-based recommendations for surveillance of endocrine disorders in CAYA cancer survivors inform healthcare providers and highlight the need for long-term endocrine follow-up care in subgroups of survivors and elucidate opportunities for further research. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Bariatric Surgery for Hypothalamic Obesity in Craniopharyngioma Patients: A Retrospective, Matched Case-Control Study

Author

van Santen, Selveta S, primary, Wolf, Peter, additional, Kremenevski, Natalia, additional, Boguszewski, Cesar L, additional, Beiglböck, Hannes, additional, Fiocco, Marta, additional, Wijnen, Mark, additional, Wallenius, Ville R, additional, van den Heuvel-Eibrink, Marry M, additional, van der Lely, Aart J, additional, Johannsson, Gudmundur, additional, Luger, Anton, additional, Krebs, Michael, additional, Buchfelder, Michael, additional, Delhanty, Patric J D, additional, Neggers, Sebastian J C M M, additional, and Olsson, Daniel S, additional

Published
2021
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24. Predictors for Remission after Transsphenoidal Surgery in Acromegaly: A Dutch Multicenter Study

Author

Coopmans, Eva C., Postma, M.R., Wolters, T.L.C., Meyel, Sebastiaan W.F. van, Netea-Maier, R.T., Beek, Andre P. van, Neggers, Sebastian J. C. M. M., Coopmans, Eva C., Postma, M.R., Wolters, T.L.C., Meyel, Sebastiaan W.F. van, Netea-Maier, R.T., Beek, Andre P. van, and Neggers, Sebastian J. C. M. M.

Abstract

Contains fulltext : 234210.pdf (Publisher’s version ) (Open Access)

Published
2021

25. Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors : evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja H., Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., Di Iorgi, Natascia, van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja H., Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., and Di Iorgi, Natascia

Abstract

Childhood, adolescent, and young adult cancer survivors are at increased risk of reduced bone mineral density. Clinical practice surveillance guidelines are important for timely diagnosis and treatment of these survivors, which could improve bone mineral density parameters and prevent fragility fractures. Discordances across current late effects guidelines necessitated international harmonisation of recommendations for bone mineral density surveillance. The International Late Effects of Childhood Cancer Guideline Harmonization Group therefore established a panel of 36 experts from ten countries, representing a range of relevant medical specialties. The evidence of risk factors for very low and low bone mineral density and fractures, surveillance modality, timing of bone mineral density surveillance, and treatment of very low and low bone mineral density were evaluated and critically appraised, and harmonised recommendations for childhood, adolescent, and young adult cancer survivors were formulated. We graded the recommendations based on the quality of evidence and balance between potential benefits and harms. Bone mineral density surveillance is recommended for survivors treated with cranial or craniospinal radiotherapy and is reasonable for survivors treated with total body irradiation. Due to insufficient evidence, no recommendation can be formulated for or against bone mineral density surveillance for survivors treated with corticosteroids. This surveillance decision should be made by the survivor and health-care provider together, after careful consideration of the potential harms and benefits and additional risk factors. We recommend to carry out bone mineral density surveillance using dualenergy x-ray absorptiometry at entry into long-term follow-up, and if normal (Z-score > -1), repeat when the survivor is aged 25 years. Between these measurements and thereafter, surveillance should be done as clinically indicated. These recommendations facilitate evidenc

Published
2021
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26. Overweight in the Dutch National Cohort of Long-Term Survivors of Childhood Cancer

Author

Child Health, Arts-assistenten Radiologie, SCT patientenzorg, MS Radiotherapie, Zorg en O&O, Endocrinologie patientenzorg, Brain, Cancer, Speerpunt, Pluimakers, Vincent, Van Atteveld, Jenneke E., de Winter, Demi T.C., Fiocco, M., Nievelstein, Rutger Jan, Bresters, Dorine, van der Heiden-van der Loo, Margriet, de Vries, Andrica C, Janssens, Geert O, Louwerens, Marloes, van der Pal, Helena J H, Ronckers, Cécile, van Santen, HM, Versluijs, Birgitta, Kremer, Leontien, Loonen, Jacqueline J, Tissing, Wim, Van Dulmen-Den Broeder, Eline, van den Heuvel-Eibrink, M.M., Neggers, Sebastian J C M M, Child Health, Arts-assistenten Radiologie, SCT patientenzorg, MS Radiotherapie, Zorg en O&O, Endocrinologie patientenzorg, Brain, Cancer, Speerpunt, Pluimakers, Vincent, Van Atteveld, Jenneke E., de Winter, Demi T.C., Fiocco, M., Nievelstein, Rutger Jan, Bresters, Dorine, van der Heiden-van der Loo, Margriet, de Vries, Andrica C, Janssens, Geert O, Louwerens, Marloes, van der Pal, Helena J H, Ronckers, Cécile, van Santen, HM, Versluijs, Birgitta, Kremer, Leontien, Loonen, Jacqueline J, Tissing, Wim, Van Dulmen-Den Broeder, Eline, van den Heuvel-Eibrink, M.M., and Neggers, Sebastian J C M M

Published
2021

27. Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors: evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

MS Radiologie, Circulatory Health, van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja, Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., Di Iorgi, Natascia, MS Radiologie, Circulatory Health, van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja, Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., and Di Iorgi, Natascia

Published
2021

28. Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols

Author

PMC Research, van Atteveld, Jenneke E, de Groot-Kruseman, Hester A, Fiocco, Marta, Lequin, Maarten H, Neggers, Sebastian J C M M, Pluijm, Saskia M F, van der Sluis, Inge M, Pieters, Rob, van den Heuvel-Eibrink, Marry M, PMC Research, van Atteveld, Jenneke E, de Groot-Kruseman, Hester A, Fiocco, Marta, Lequin, Maarten H, Neggers, Sebastian J C M M, Pluijm, Saskia M F, van der Sluis, Inge M, Pieters, Rob, and van den Heuvel-Eibrink, Marry M

Published
2021

30. Hypertension in Acromegaly in Relationship to Biochemical Control and Mortality: Global ACROSTUDY Outcomes

Author

Vila, Greisa, Luger, Anton, van der Lely, Aart Jan, Neggers, Sebastian J. C. M. M., Webb, S. M.., Biller, Beverly M. K., Valluri, Srinivas, Hey-Hadavi, Judith, Universitat Autònoma de Barcelona, and Internal Medicine

Subjects
Adult, Male, medicine.medical_specialty, hypertension, Endocrinology, Diabetes and Metabolism, Pegvisomant, 030209 endocrinology & metabolism, Context (language use), Hypopituitarism, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, cardiovascular disease, Diabetes mellitus, Internal medicine, Acromegaly, medicine, Humans, Risk factor, Mortality, pegvisomant, Original Research, Retrospective Studies, lcsh:RC648-665, business.industry, Human Growth Hormone, Middle Aged, medicine.disease, Cardiovascular disease, Prognosis, mortality, Survival Rate, Blood pressure, hypopituitarism, Cardiovascular Diseases, Case-Control Studies, Cohort, Hypertension, Female, business, medicine.drug, Follow-Up Studies
Abstract

ContextHypertension is a major cardiovascular risk factor related to increased mortality in acromegaly. Surgical cure of acromegaly is associated with improvement in blood pressure levels, however little is known about the effect of pegvisomant (PEGV) treatment in patients with hypertension. This analysis evaluates outcomes in patients with hypertension and acromegaly included in ACROSTUDY.MethodsACROSTUDY is a global non-interventional surveillance study of long-term treatment with PEGV, monitoring its safety and efficacy. The cohort was retrospectively divided in two subgroups: patients with and without hypertension. Stepwise logistic regression and Kaplan-Meyer analyses were performed for testing predictors of mortality.ResultsThe total cohort included 2,090 patients with acromegaly treated with PEGV who were followed for a median of 6.8 years (range up to 12.1 years). In ACROSTUDY there were 1,344 patients with hypertension (52.3% males). This subgroup was older, had a higher BMI, and higher prevalence of diabetes, hyperlipidemia, and cardiovascular disease (CVD) when compared to patients without hypertension. During ACROSTUDY, 68 deaths were reported in the hypertension cohort, vs 10 in the cohort without hypertension. Both CVD (pConclusionsHypertension is common in patients with acromegaly and significantly increases mortality, especially when there is concomitant CVD. These data suggest that treatment goals should extend beyond IGF-I normalization, and include optimisation of substitution of pituitary deficiencies and scrutinous screening and treatment of CVD.

Published
2020

31. Risk factors associated with tinnitus in 2948 Dutch survivors of childhood cancer: a Dutch LATER questionnaire study

Author

MS Radiotherapie, Cancer, PMC Medisch specialisten, Child Health, Zorgeenheid KNO Medisch, Brain, Audiologen, Meijer, Annelot J M, Fiocco, Marta F, Janssens, Geert O, Clemens, Eva, Tissing, Wim J E, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Bresters, Dorine, Versluys, Birgitta, Ronckers, Cécile M, Kremer, Leontien C M, van der Pal, Helena J, Neggers, Sebastian J C M M, van der Heiden-van der Loo, Margriet, Stokroos, Robert J, Hoetink, Alex E, van Grotel, Martine, van den Heuvel-Eibrink, Marry M, MS Radiotherapie, Cancer, PMC Medisch specialisten, Child Health, Zorgeenheid KNO Medisch, Brain, Audiologen, Meijer, Annelot J M, Fiocco, Marta F, Janssens, Geert O, Clemens, Eva, Tissing, Wim J E, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Bresters, Dorine, Versluys, Birgitta, Ronckers, Cécile M, Kremer, Leontien C M, van der Pal, Helena J, Neggers, Sebastian J C M M, van der Heiden-van der Loo, Margriet, Stokroos, Robert J, Hoetink, Alex E, van Grotel, Martine, and van den Heuvel-Eibrink, Marry M

Published
2020

36. Body Composition and Bone Mineral Density in Craniopharyngioma Patients: A Longitudinal Study Over 10 Years

Author

van Santen, Selveta S, primary, Olsson, Daniel S, additional, Hammarstrand, Casper, additional, Wijnen, Mark, additional, Fiocco, Marta, additional, van den Heuvel-Eibrink, Marry M, additional, Johannsson, Gudmundur, additional, Janssen, Joseph A M J L, additional, van der Lely, Aart J, additional, and Neggers, Sebastian J C M M, additional

Published
2020
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37. Multivariable Prediction Model for Biochemical Response to First-Generation Somatostatin Receptor Ligands in Acromegaly

Author

Coopmans, Eva C, primary, Korevaar, Tim I M, additional, van Meyel, Sebastiaan W F, additional, Daly, Adrian F, additional, Chanson, Philippe, additional, Brue, Thierry, additional, Delemer, Brigitte, additional, Hána, Václav, additional, Colao, Annamaria, additional, Carvalho, Davide, additional, Jaffrain-Rea, Marie-Lise, additional, Stalla, Günter K, additional, Fajardo-Montañana, Carmen, additional, Beckers, Albert, additional, van der Lely, Aart J, additional, Petrossians, Patrick, additional, and Neggers, Sebastian J C M M, additional

Published
2020
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38. SAT-LB60 Discordant Biological Parameters of Remission in Acromegaly Do Not Increase the Risk of Hypertension or Diabetes: A Study With the Liege Acromegaly Survey Database

Author

Amodru, Vincent, primary, Petrossians, Patrick, primary, Colao, Annamaria, primary, Delemer, Brigitte, primary, Maione, Luigi, primary, Neggers, Sebastian J C M M, primary, Decoudier, Benedicte, primary, Kamenicky, Peter, primary, Castinetti, Frederic, primary, Hana, Vaclav, primary, Pivonello, Rosario, primary, Carvahlo, Davide, primary, Brue, Thierry Christian, primary, Beckers, Albert M, primary, Chanson, Philippe, primary, and CUNY, Thomas, primary

Published
2020
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41. Risk factors associated with tinnitus in 2948 Dutch survivors of childhood cancer: a Dutch LATER questionnaire study

Author

Meijer, Annelot J M, primary, Fiocco, Marta F, additional, Janssens, Geert O, additional, Clemens, Eva, additional, Tissing, Wim J E, additional, Loonen, Jacqueline J, additional, van Dulmen-den Broeder, Eline, additional, de Vries, Andrica C H, additional, Bresters, Dorine, additional, Versluys, Birgitta, additional, Ronckers, Cécile M, additional, Kremer, Leontien C M, additional, van der Pal, Helena J, additional, Neggers, Sebastian J C M M, additional, van der Heiden-van der Loo, Margriet, additional, Stokroos, Robert J, additional, Hoetink, Alex E, additional, van Grotel, Martine, additional, and van den Heuvel-Eibrink, Marry M, additional

Published
2020
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42. Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort : Contributions of radiation dose, exposed cranial volume, and age

Author

Kok, Judith L, Teepen, Jop C, van Leeuwen, Flora E, Tissing, Wim J E, Neggers, Sebastian J C M M, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, Birgitta, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, Aleman, Berthe M P, Daniels, Laurien A, Haasbeek, Cornelis J A, Hoeben, Bianca, Janssens, Geert O, Maduro, John H, Oldenburger, Foppe, van Rij, Caroline, Tersteeg, Robbert J H A, Hauptmann, Michael, Kremer, Leontien C M, Ronckers, Cécile M, and DCOG-LATER Study Group

Subjects
Cancer Research, Oncology, childhood cancer survivors, Clinical Neurology, cranial radiotherapy, radiation volume, radiation dose, meningioma
Abstract

Background. Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma risk factors with emphasis on independent and joint effects of CrRT dose, exposed cranial volume, exposure age, and chemotherapy. Methods. The Dutch Cancer Oncology Group-Long-Term Effects after Childhood Cancer (DCOG-LATER) cohort includes 5-year childhood cancer survivors (CCSs) whose cancers were diagnosed in 1963-2001. Histologically confirmed benign meningiomas were identified from the population-based Dutch Pathology Registry (PALGA; 1990-2015). We calculated cumulative meningioma incidence and used multivariable Cox regression and linear excess relative risk (ERR) modeling. Results. Among 5843 CCSs (median follow-up: 23.3 y, range: 5.0-52.2 y), 97 developed a benign meningioma, including 80 after full- and 14 after partial-volume CrRT. Compared with CrRT doses of 1-19 Gy, no CrRT was associated with a low meningioma risk (hazard ratio [HR] = 0.04, 95% CI: 0.01-0.15), while increased risks were observed for CrRT doses of 20-39 Gy (HR = 1.66, 95% CI: 0.83-3.33) and 40+ Gy (HR = 2.81, 95% CI: 1.30-6.08). CCSs whose cancers were diagnosed before age 5 versus 10-17 years showed significantly increased risks (HR = 2.38, 95% CI: 1.39-4.07). In this dose-adjusted model, volume was not significantly associated with increased risk (HR full vs partial = 1.66, 95% CI: 0.86-3.22). Overall, the ERR/Gy was 0.30 (95% CI: 0.03-unknown). Dose effects did not vary significantly according to exposure age or CrRT volume. Cumulative incidence after any CrRT was 12.4% (95% CI: 9.8%-15.2%) 40 years after primary cancer diagnosis. Among chemotherapy agents (including methotrexate and cisplatin), only carboplatin (HR = 3.55, 95% CI: 1.62-7.78) appeared associated with meningioma risk. However, we saw no carboplatin dose-response and all 9 exposed cases had high-dose CrRT. Conclusion. After CrRT 1 in 8 survivors developed late meningioma by age 40 years, associated with radiation dose and exposure age, relevant for future treatment protocols and awareness among survivors and physicians.

Published
2019

44. Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer

Author

Kok, Judith L., Teepen, J.C., Pal, Helena J. van der, Leeuwen, F.E. van, Tissing, W.J., Neggers, Sebastian J. C. M. M., Loonen, J.J., Hoeben, B.A.W., Jongmans, M.C.J., Kremer, L.C., Ronckers, C., Rij, C.M. van, Tersteeg, R.J.H.A., Kok, Judith L., Teepen, J.C., Pal, Helena J. van der, Leeuwen, F.E. van, Tissing, W.J., Neggers, Sebastian J. C. M. M., Loonen, J.J., Hoeben, B.A.W., Jongmans, M.C.J., Kremer, L.C., Ronckers, C., Rij, C.M. van, and Tersteeg, R.J.H.A.

Abstract

Contains fulltext : 204007.pdf (Publisher’s version ) (Closed access)

Published
2019

45. Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age

Author

Kok, Judith L., Teepen, J.C., Leeuwen, F.E. van, Tissing, W.J., Neggers, Sebastian J. C. M. M., Pal, Helena J. van der, Loonen, J.J., Hoeben, B.A.W., Kremer, L.C., Ronckers, C.M., Kok, Judith L., Teepen, J.C., Leeuwen, F.E. van, Tissing, W.J., Neggers, Sebastian J. C. M. M., Pal, Helena J. van der, Loonen, J.J., Hoeben, B.A.W., Kremer, L.C., and Ronckers, C.M.

Abstract

Contains fulltext : 202450.pdf (publisher's version ) (Closed access)

Published
2019

46. Long-Term Risk of Skin Cancer Among Childhood Cancer Survivors: A DCOG-LATER Cohort Study

Author

Teepen, J.C., Kok, Judith L., Kremer, Leontien C., Tissing, W.J., Heuvel-Eibrink, M.M. van den, Loonen, J.J., Neggers, Sebastian J. C. M. M., Schaapveld, M., Teepen, J.C., Kok, Judith L., Kremer, Leontien C., Tissing, W.J., Heuvel-Eibrink, M.M. van den, Loonen, J.J., Neggers, Sebastian J. C. M. M., and Schaapveld, M.

Abstract

Contains fulltext : 209672.pdf (Publisher’s version ) (Closed access)

Published
2019

47. Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: Contributions of radiation dose, exposed cranial volume, and age

Author

PMC Medisch specialisten, SCT patientenzorg, Child Health, Zorg en O&O, MS Radiotherapie, Cancer, Klinische Fysica RT, Kok, Judith L, Teepen, Jop C, van Leeuwen, Flora E, Tissing, Wim J E, Neggers, Sebastian J C M M, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, Birgitta, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, Aleman, Berthe M P, Daniels, Laurien A, Haasbeek, Cornelis J A, Hoeben, Bianca, Janssens, Geert O, Maduro, John H, Oldenburger, Foppe, van Rij, Caroline, Tersteeg, Robbert J H A, Hauptmann, Michael, Kremer, Leontien C M, Ronckers, Cécile M, DCOG-LATER Study Group, PMC Medisch specialisten, SCT patientenzorg, Child Health, Zorg en O&O, MS Radiotherapie, Cancer, Klinische Fysica RT, Kok, Judith L, Teepen, Jop C, van Leeuwen, Flora E, Tissing, Wim J E, Neggers, Sebastian J C M M, van der Pal, Helena J, Loonen, Jacqueline J, Bresters, Dorine, Versluys, Birgitta, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, Aleman, Berthe M P, Daniels, Laurien A, Haasbeek, Cornelis J A, Hoeben, Bianca, Janssens, Geert O, Maduro, John H, Oldenburger, Foppe, van Rij, Caroline, Tersteeg, Robbert J H A, Hauptmann, Michael, Kremer, Leontien C M, Ronckers, Cécile M, and DCOG-LATER Study Group

Published
2019

48. Endocrine Disorders Are Prominent Clinical Features in Patients With Primary Antibody Deficiencies

Author

Coopmans, Eva C., primary, Chunharojrith, Paweena, additional, Neggers, Sebastian J. C. M. M., additional, van der Ent, Marianne W., additional, Swagemakers, Sigrid M. A., additional, Hollink, Iris H., additional, Barendregt, Barbara H., additional, van der Spek, Peter J., additional, van der Lely, Aart-Jan, additional, van Hagen, P. Martin, additional, and Dalm, Virgil A. S. H., additional

Published
2019
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