1. Effect of fruit extract on renal stone formation and kidney injury in rats
- Author
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S. Jamilaldin Fatemi, Mohammad Reza Ebadzadeh, Mohammad Khaksari, and Nasrin Partovi
- Subjects
Male ,medicine.medical_specialty ,Ethylene Glycol ,Calcium oxalate ,Plant Science ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,Superoxide dismutase ,chemistry.chemical_compound ,Kidney Calculi ,Oral administration ,Internal medicine ,Malondialdehyde ,medicine ,Animals ,Rats, Wistar ,Ethanol ,biology ,Calcium Oxalate ,010405 organic chemistry ,Chemistry ,Plant Extracts ,Organic Chemistry ,Opuntia ,medicine.disease ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Endocrinology ,Fruit ,Cactus ,biology.protein ,Kidney stones ,Ethylene glycol - Abstract
This study investigated the effect of oral administration of Cactus fruit extracts on calcium oxalate deposition, malondialdehyde (MDA) and superoxide dismutase (SOD) activity in rat model. About 42 rats were used for the study. The animals were divided into seven groups. Control group maintained on regular rat food and drinking water throughout the study period, whereas in other groups nephrolithiasis was induced by ethylene glycol. Rats in kidney stone group were sacrificed after 28 days and all remaining groups after 58 days. Treatment groups were treated with 1 and 100 mg/kg of aqueous and ethanolic extracts of Cactus fruit for 30 days. After treatment, SOD activity was increased and MDA was decreased significantly. CaOx depositions were decreased significantly, especially in ethanolic extract of Cactus fruit in high dose (100 mg/kg).
- Published
- 2017