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4. Additional file 1 of Co-occurrence of relapsing polychondritis and autoimmune thyroid diseases

Author

Nakajima, Toshiki, Yoshifuji, Hajime, Yamano, Yoshihisa, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Yoshida, Tsuneyasu, Handa, Hiroshi, Ohmura, Koichiro, Mimori, Tsuneyo, and Terao, Chikashi

Subjects
endocrine system, endocrine system diseases, immune system diseases
Abstract

Additional file 1. Differences of organ involvement between patients with and without Hashimoto thyroiditis.

Published
2022
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6. Brief Report: Takayasu Arteritis and Ulcerative Colitis: High Rate of Co-Occurrence and Genetic Overlap

Author

Terao, Chikashi, Matsumura, Takayoshi, Yoshifuji, Hajime, Kirino, Yohei, Maejima, Yasuhiro, Nakaoka, Yoshikazu, Takahashi, Meiko, Amiya, Eisuke, Tamura, Natsuko, Nakajima, Toshiki, Origuchi, Tomoki, Horita, Tetsuya, Matsukura, Mitsuru, Kochi, Yuta, Ogimoto, Akiyoshi, Yamamoto, Motohisa, Takahashi, Hiroki, Nakayamada, Shingo, Saito, Kazuyoshi, Wada, Yoko, Narita, Ichiei, Kawaguchi, Yasushi, Yamanaka, Hisashi, Ohmura, Koichiro, Atsumi, Tatsuya, Tanemoto, Kazuo, Miyata, Tetsuro, Kuwana, Masataka, Komuro, Issei, Tabara, Yasuharu, Ueda, Atsuhisa, Isobe, Mitsuaki, Mimori, Tsuneyo, and Matsuda, Fumihiko

Published
2015
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7. Long-term outcomes of refractory Takayasu arteritis patients treated with biologics including ustekinumab

Author

Gon, Yoshie, Yoshifuji, Hajime, Nakajima, Toshiki, Murakami, Kosaku, Nakashima, Ran, Ohmura, Koichiro, Tsuneyo Mimori, and Terao, Chikashi

Abstract

Biologics have been used to treat refractory Takayasu arteritis (TAK), but their efficacy and safety have not been sufficiently evaluated. We extracted clinical information from medical records for TAK patients who were treated with biologics including ustekinumab (UST) at Kyoto University Hospital. We also analysed the patient’s genetic backgrounds. Of 163 cases, 12 (7.4%) were treated with infliximab, tocilizumab, or UST (n = 3). Erythrocyte sedimentation rate (ESR), C-reactive protein levels (CRP), and prednisolone (PSL) dose were significantly decreased 12 months after the initiation of biologics. When compared with the 15 patients who were only treated with immunosuppressants (IS group), the change in ESR from baseline was significantly lower in the biologics group than in the IS group (−2 mm/h, p = .005). The proportion of patients with HLA-B*52 and the risk-type alleles of the SNP were similar in both groups. Among the biologics, TCZ showed the highest continuation rate. UST exhibited marginal effects on reducing ESR, CRP levels, and PSL dose. No adverse events were observed in patients with UST for approximately 3 years. Biological treatments resulted in a reduction in inflammatory markers and PSL dose in refractory TAK patients.

Published
2020
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8. Self‐Organization of Remote Reservoirs: Transferring Computation to Spatially Distant Locations.

Author

Tanaka, Kazutoshi, Tokudome, Yuji, Minami, Yuna, Honda, Satoko, Nakajima, Toshiki, Takei, Kuniharu, and Nakajima, Kohei

Abstract

Soft materials generate rich and diverse dynamics that can be used as computational resources based on the framework of physical reservoir computing. Herein, a method that exploits the dynamic coupling between soft structures and a water medium to allow for the transfer of computation to spatially distant locations is proposed. This technique is implemented by introducing the concept of remote reservoirs that can autonomously alter their physical constituents in real time rather than using reservoirs with predefined, fixed physical constituents. These remote reservoirs self‐organize by including many ad hoc physical substrates in the environment, making the framework more flexible for soft robotic applications. Using a simple experimental platform consisting of silicone rubber strips containing embedded flexible strain sensors, it is demonstrated that the dynamics of passive silicone rubber strips located at a distance from the actuation point can be successfully exploited for computation through generalized synchronization realized via the medium of water. Future application scenarios are illustrated, in which the proposed technique is applied in emergency situations as a communication tool for transferring a message to a location that humans cannot easily access. For example, the technique could be applied to communicate with people trapped in submerged caves. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Additional file 1: Supplement 1. of A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production

Author

Nakajima, Toshiki, Yoshifuji, Hajime, Shimizu, Masakazu, Kitagori, Koji, Murakami, Kosaku, Nakashima, Ran, Imura, Yoshitaka, Tanaka, Masao, Ohmura, Koichiro, Matsuda, Fumihiko, Terao, Chikashi, and Tsuneyo Mimori

Abstract

Correlations of the plasma concentration of IL-12p40 with those of IL-12p70 and IL-23. a The plasma concentration of IL-12p40 was correlated with that of IL-12p70 (rho = 0.33, p = 0.027). b There were no correlation between the plasma concentrations of IL-12p40 and IL-23. Supplement 2. Correlation between the proportion of CXCR3+ cells among CD3+CD4+ cells and the dose of glucocorticoids. The proportion of CXCR3+ cells among CD3+CD4+ cells was negatively correlated with the dose of glucocorticoids (rho = − 0.63 and p

Published
2017
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12. Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes

Author

Miyagawa-Hayashino, Aya, primary, Yoshifuji, Hajime, additional, Kitagori, Koji, additional, Ito, Shinji, additional, Oku, Takuma, additional, Hirayama, Yoshitaka, additional, Salah, Adeeb, additional, Nakajima, Toshiki, additional, Kiso, Kaori, additional, Yamada, Norishige, additional, Haga, Hironori, additional, and Tsuruyama, Tatsuaki, additional

Published
2018
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14. A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production

Author

Nakajima, Toshiki, primary, Yoshifuji, Hajime, additional, Shimizu, Masakazu, additional, Kitagori, Koji, additional, Murakami, Kosaku, additional, Nakashima, Ran, additional, Imura, Yoshitaka, additional, Tanaka, Masao, additional, Ohmura, Koichiro, additional, Matsuda, Fumihiko, additional, Terao, Chikashi, additional, and Mimori, Tsuneyo, additional

Published
2017
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17. Cleaved Form of Osteopontin in Urine as a Clinical Marker of Lupus Nephritis

Author

Kitagori, Koji, primary, Yoshifuji, Hajime, additional, Oku, Takuma, additional, Sasaki, Chiyomi, additional, Miyata, Hitomi, additional, Mori, Keita P., additional, Nakajima, Toshiki, additional, Ohmura, Koichiro, additional, Kawabata, Daisuke, additional, Yukawa, Naoichiro, additional, Imura, Yoshitaka, additional, Murakami, Kosaku, additional, Nakashima, Ran, additional, Usui, Takashi, additional, Fujii, Takao, additional, Sakai, Kaoru, additional, Yanagita, Motoko, additional, Hirayama, Yoshitaka, additional, and Mimori, Tsuneyo, additional

Published
2016
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19. A novel susceptibility locus in the IL12Bregion is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production

Author

Nakajima, Toshiki, Yoshifuji, Hajime, Shimizu, Masakazu, Kitagori, Koji, Murakami, Kosaku, Nakashima, Ran, Imura, Yoshitaka, Tanaka, Masao, Ohmura, Koichiro, Matsuda, Fumihiko, Terao, Chikashi, and Mimori, Tsuneyo

Abstract

A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common component of IL-12p70 and IL-23. We investigated the expression of these cytokines in patients with TAK, stratifying them into those with or without the risk allele at the rs6871626 SNP. Plasma levels of IL-12p40, IL-12p70, and IL-23 were quantified in 44 patients with TAK and 19 healthy controls (HCs) by enzyme-linked immunosorbent assays. Monocytes were obtained from 20 patients with TAK and 14 HCs, treated with interferon-γ (IFN-γ) and lipopolysaccharide, and then supernatant cytokines were quantified. In addition, the ratio of IFN-γ+or IL-17A+cells to CD4+T cells was measured by flow cytometric analysis of peripheral blood mononuclear cells. The levels of plasma IL-12p40, plasma IL-12p70, and supernatant IL-12p70 were significantly higher in patients with TAK than in HCs, whereas there were no significant differences in the levels of plasma IL-23, supernatant IL-23, or supernatant IL-12p40. The levels of plasma IL-12p70, supernatant IL-12p40, and supernatant IL-12p70 were significantly higher in patients with the risk allele than in those without. The ratio of CD4+IFN-γ+cells was significantly higher in patients with the risk allele, whereas CD4+IL-17A+cells showed no differences. The rs6871626 SNP in IL12Bmay influence the increased expression of IL-12p40 and IL-12p70. These enhanced cytokines might play roles in the pathophysiology of TAK.

Published
2017
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20. Efficacy of Glimepiride in Patients with Poorly Controlled Insulin-treated Type 2 Diabetes Mellitus

Author

OSE, Hiroyuki, primary, FUKUI, Michiaki, additional, KITAGAWA, Yoshihiro, additional, HIRATA, Chizuko, additional, ICHIO, Naoko, additional, KADONO, Mayuko, additional, MOGAMI, Shin-ichi, additional, ONISHI, Masayoshi, additional, ICHIDA, Yukiko, additional, NAKAJIMA, Toshiki, additional, HASEGAWA, Goji, additional, YOSHIKAWA, Toshikazu, additional, and NAKAMURA, Naoto, additional

Published
2005
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22. Rechargeable Lithium/Polymer Cathode Batteries

Author

MINNESOTA UNIV MINNEAPOLIS DEPT OF CHEMICAL ENGINEERING AND MATERIALS SCIENCE, Osaka, Tetsuya, Nakajima, Toshiki, Shiota, Koh, Owens, Boone B., MINNESOTA UNIV MINNEAPOLIS DEPT OF CHEMICAL ENGINEERING AND MATERIALS SCIENCE, Osaka, Tetsuya, Nakajima, Toshiki, Shiota, Koh, and Owens, Boone B.

Abstract

Polypyrrole (PPy) and polyaniline (PAn) were investigated for cathode materials of rechargeable lithium batteries. PPy films prepared with PF6(-) anion and/or Platinum substrate precoated with nitrile butadiene rubber(NBR) were excellent cathode materials because of rough and/or highly oriented film structure. PAn films were successfully prepared from non-aqueous propylene carbonate solution containing aniline, CF3COOH and Lithium perchlorate. Its acidity strongly affects the anion doping-undoping behavior. The PAn cathode prepared in high acidic solution (e.g. 4:1 ratio of acid:aniline) gives the excellent battery performance.

Published
1989

23. Electroactive Polyaniline Film Deposited from Non-Aqueous Media 2: Effect of Acid Concentration in Solutions

Author

MINNESOTA UNIV MINNEAPOLIS CORROSION RESEARCH CENTER, Osaka, Tetsuya, Nakajima, Toshiki, Naoi, Katsuhiko, Owens, Boone B., MINNESOTA UNIV MINNEAPOLIS CORROSION RESEARCH CENTER, Osaka, Tetsuya, Nakajima, Toshiki, Naoi, Katsuhiko, and Owens, Boone B.

Abstract

Polyaniline films electro-deposited from acidified non-aqueous media were investigated for their electropolymerization behavior and charge-discharge characteristics. The solution system used for the electropolymerization of polyaniline films was CF3COOH acidified propylene carbonate, which was previously found to be the best system for the preparation of highly electroactive conducting polymer film. Electroactive polyaniline films only form in solutions wherein the mole ratio of acid (CF3COOH) to aniline monomer is greater than one. As the acidity is increased, the resultant polyaniline film exhibits greater electroactivity and better charge-discharge performance. Keywords: Polyaniline; Redox polymer; Nonaqueous electrolytes. (JES)

Published
1989

24. Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap.

Author

Terao C, Matsumura T, Yoshifuji H, Kirino Y, Maejima Y, Nakaoka Y, Takahashi M, Amiya E, Tamura N, Nakajima T, Origuchi T, Horita T, Matsukura M, Kochi Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Wada Y, Narita I, Kawaguchi Y, Yamanaka H, Ohmura K, Atsumi T, Tanemoto K, Miyata T, Kuwana M, Komuro I, Tabara Y, Ueda A, Isobe M, Mimori T, and Matsuda F

Subjects
Adult, Colitis, Ulcerative epidemiology, Comorbidity, Female, Genetic Predisposition to Disease, Humans, Japan epidemiology, Male, Middle Aged, Prevalence, Takayasu Arteritis epidemiology, Young Adult, Colitis, Ulcerative genetics, HLA-B52 Antigen genetics, Interleukin-12 Subunit p40 genetics, Takayasu Arteritis genetics
Abstract

Objective: Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and large branches of the aorta. Ulcerative colitis (UC) is a prevalent autoimmune colitis. Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. We undertook this study to perform a large-scale analysis of TAK, both to evaluate the prevalence of concurrent cases of TAK and UC and to identify and estimate susceptibility genes shared between the 2 diseases., Methods: We analyzed a total of 470 consecutive patients with TAK from 14 institutions. We characterized patients with TAK and UC by analyzing clinical manifestations and genetic components. Genetic overlapping of TAK and UC was evaluated with the use of UC susceptibility single-nucleotide polymorphisms by comparing risk directions and effect sizes between susceptibility to the 2 diseases., Results: Thirty of 470 patients with TAK had UC (6.4% [95% confidence interval 4.3-9.0]). This percentage was strikingly higher than that expected from the prevalence of UC in Japan. Patients with TAK complicated with UC developed TAK at an earlier stage of life (P = 0.0070) and showed significant enrichment of HLA-B*52:01 compared to TAK patients without UC (P = 1.0 × 10(-5) ) (odds ratio 12.14 [95% confidence interval 2.96-107.23]). The 110 non-HLA markers of susceptibility to UC significantly displayed common risk directions with susceptibility to TAK (P = 0.0054) and showed significant departure of permutation P values from expected P values (P < 1.0 × 10(-10) )., Conclusion: UC is a major complication of TAK. These 2 diseases share a significant proportion of their genetic background, and HLA-B*52:01 may play a central role in their co-occurrence., (© 2015, American College of Rheumatology.)

Published
2015
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