1,289 results on '"Nair, N."'
Search Results
2. Pathological changes caused by highly pathogenic Escherichia coli infection in pigs
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Krithiga, K., Nair, N. Divakaran, Vijayan, N., Anitha, R., Abraham, J. Mammen, and Lalithakunjamma, C.R.
- Published
- 2012
3. High-pressure control of optical nonlinearity in the polar Weyl semimetal TaAs
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Li, Chen, Li, Xiang, Deshpande, T., Li, Xinwei, Nair, N., Analytis, J. G., Silevitch, D. M., Rosenbaum, T. F., and Hsieh, D.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics - Abstract
The transition metal monopnictide family of Weyl semimetals recently has been shown to exhibit anomalously strong second-order optical nonlinearity, which is theoretically attributed to a highly asymmetric polarization distribution induced by their polar structure. We experimentally test this hypothesis by measuring optical second harmonic generation (SHG) from TaAs across a pressure-tuned polar-to-nonpolar structural phase transition. Despite the high-pressure structure remaining noncentrosymmetric, the SHG yield is reduced by more than 60 % by 20 GPa as compared to the ambient pressure value. By examining the pressure dependence of distinct groups of SHG susceptibility tensor elements, we find that the yield is primarily controlled by a single element that governs the response along the polar axis. Our results confirm a connection between the polar axis and the giant optical nonlinearity of Weyl semimetals and demonstrate pressure as a means to tune this effect $in$ $situ$., Comment: 5 pages main text, 4 figures, 2 pages supplementary information
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- 2022
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4. Effect of cytoplasmic diversity on performance of sugarcane hybrids
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Ram, Bakshi, Nair, N. V., Radhakrishnan, C. M., Singh, N., and Sahi, B. K.
- Published
- 2007
5. Topological surface conduction in Kondo insulator YbB$_{12}$
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Sato, Y., Xiang, Z., Kasahara, Y., Kasahara, S., Chen, Lu, Tinsman, C., Iga, F., Singleton, J., Nair, N. L., Maksimovic, N., Analytis, J. G., Li, Lu, and Matsuda, Y.
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Condensed Matter - Strongly Correlated Electrons - Abstract
Kondo insulators have recently aroused great interest because they are promising materials that host a topological insulator state caused by the strong electron interactions. Moreover, recent observations of the quantum oscillations in the insulating state of Kondo insulators have come as a great surprise. Here, to investigate the surface electronic state of a prototype Kondo insulator YbB$_{12}$, we measured transport properties of single crystals and microstructures. In all samples, the temperature dependence of the electrical resistivity is insulating at high temperatures and the resistivity exhibits a plateau at low temperatures. The magnitude of the plateau value decreases with reducing sample thickness, which is quantitatively consistent with the surface electronic conduction in the bulk insulating YbB$_{12}$. Moreover, the magnetoresistance of the microstructures exhibits a weak-antilocalization effect at low field. These results are consistent with the presence of topologically protected surface state, suggesting that YbB$_{12}$ is a candidate material of the topological Kondo insulator. The high field resistivity measurements up to $\mu_0H$ = 50 T of the microstructures provide supporting evidence that the quantum oscillations of the resistivity in YbB$_{12}$ occurs in the insulating bulk., Comment: This is the version of the article before peer review or editing, as submitted by an author to Journal of Physics D: Applied Physics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at 10.1088/1361-6463/ac10d9
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- 2021
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6. Field-angle dependence of sound velocity in the Weyl semimetal TaAs
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Laliberté, F., Bélanger, F., Nair, N. L., Analytis, J. G., Boulanger, M. -E., Dion, M., Taillefer, L., and Quilliam, J. A.
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Condensed Matter - Materials Science - Abstract
The elastic modulus $c_{44}$ of a single crystal of the Weyl semimetal TaAs was investigated by measuring relative changes in the sound velocity under application of a magnetic field up to 10 T. Using an ultrasonic pulsed-echo technique, we studied the shear response of the crystal when the angle between the sound wave propagation and the magnetic field is changed. We observe a broken tetragonal symmetry at fields above 6 T, an anisotropy that is likely related to a longitudinal negative magnetoresistance and therefore might provide evidence of the chiral anomaly, one of the main topological signatures of this class of materials. We also observe quantum oscillations in the sound velocity whose frequencies vary with magnetic field orientation. A fan diagram of Landau level indices reveals topological and trivial Berry phases, depending on the field orientation, indicating a sensitivity to different Fermi surface pockets that do or do not enclose Weyl nodes respectively.
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- 2019
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7. Resonance-enhanced optical nonlinearity in the Weyl semimetal TaAs
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Patankar, Shreyas, Wu, Liang, Lu, Baozhu, Rai, Manita, Tran, Jason D., Morimoto, T., Parker, D., Grushin, Adolfo, Nair, N. L., Analytis, J. G., Moore, J. E., Orenstein, J., and Torchinsky, Darius H.
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Condensed Matter - Materials Science - Abstract
While all media can exhibit first-order conductivity describing current linearly proportional to electric field, $E$, the second-order conductivity, $\sigma^{(2)}$ , relating current to $E^2$, is nonzero only when inversion symmetry is broken. Second order nonlinear optical responses are powerful tools in basic research, as probes of symmetry breaking, and in optical technology as the basis for generating currents from far-infrared to X-ray wavelengths. The recent surge of interest in Weyl semimetals with acentric crystal structures has led to the discovery of a host of $\sigma^{(2)}$ -related phenomena in this class of materials, such as polarization-selective conversion of light to dc current (photogalvanic effects) and the observation of giant second-harmonic generation (SHG) efficiency in TaAs at photon energy 1.5 eV. Here, we present measurements of the SHG spectrum of TaAs revealing that the response at 1.5 eV corresponds to the high-energy tail of a resonance at 0.7 eV, at which point the second harmonic conductivity is approximately 200 times larger than seen in the standard candle nonlinear crystal, GaAs. This remarkably large SHG response provokes the question of ultimate limits on $\sigma^{(2)}$ , which we address by a new theorem relating frequency-integrated nonlinear response functions to the third cumulant (or "skewness") of the polarization distribution function in the ground state. This theorem provides considerable insight into the factors that lead to the largest possible second-order nonlinear response, specifically showing that the spectral weight is unbounded and potentially divergent when the possibility of next-neighbor hopping is included., Comment: 7 pages, 4 figures
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- 2018
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8. Comparison of Bayesian, Frequentist and Machine learning models for predicting the two-year mortality of patients diagnosed with squamous cell carcinoma of the oral cavity
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Ganapathy, Sachit, Harichandrakumar, K.T., Penumadu, Prasanth, Tamilarasu, Kadhiravan, and Nair, N. Sreekumaran
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- 2022
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9. Application of bivariate meta-analytic approach for pooling effect measures of correlated multiple outcomes in medical research
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M.S., Deepthy, K.T., Harichandrakumar, Parameswaran, Sreejith, Kadhiravan, Tamilarasu, and Sreekumaran Nair, N.
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- 2022
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10. Peripheral Blood Neutrophil Nadir and Time to Platelet Recovery during Induction Chemotherapy: Predictors of Clinical Outcomes and Markers for Optimizing Induction Treatment Intensity in Acute Lymphoblastic Leukemia.
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Ramesh, Ramya, Aggarwal, Vineet, Choudhary, Amit, Basu, Debdatta, Nair, N. Sreekumaran, Ganesan, Prasanth, Dubashi, Biswajit, Govind, Rajath, and Kayal, Smita
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- 2024
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11. Effects of Vitamin D on Migraine: A Meta-Analysis
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Das, Saibal, Roy, Ayan, Behera, Sapan, Selvarajan, Sandhiya, Kamalanathan, Sadishkumar, Sahoo, Jaya, and Nair, N.
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Alfacalcidol -- Health aspects ,Migraine -- Risk factors -- Care and treatment ,Calcifediol -- Health aspects ,Vitamin D -- Health aspects ,Dietary supplements -- Health aspects ,Neurological research ,Vitamin D deficiency -- Complications and side effects ,Health - Abstract
Byline: Saibal. Das, Ayan. Roy, Sapan. Behera, Sandhiya. Selvarajan, Sadishkumar. Kamalanathan, Jaya. Sahoo, N. Nair Objective: The aim of this study was to evaluate the difference in mean serum 25-hydroxy [...]
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- 2023
12. Factors Associated With Neonatal Pneumonia and its Mortality in India: A Systematic Review and Meta-Analysis
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Nair, N. Sreekumaran, Lewis, Leslie Edward, Dhyani, Vijay Shree, Murthy, Shruti, Godinho, Myron, Lakiang, Theophilus, and Venkatesh, Bhumika T.
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- 2021
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13. Giant anisotropic nonlinear optical response in transition metal monopnictide Weyl semimetals
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Wu, Liang, Patankar, S., Morimoto, T., Nair, N. L., Thewalt, E., Little, A., Analytis, J. G., Moore, J. E., and Orenstein, J.
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Condensed Matter - Materials Science ,Physics - Optics - Abstract
Although Weyl fermions have proven elusive in high-energy physics, their existence as emergent quasiparticles has been predicted in certain crystalline solids in which either inversion or time-reversal symmetry is broken\cite{WanPRB2011,BurkovPRL2011, WengPRX2015,HuangNatComm2015}. Recently they have been observed in transition metal monopnictides (TMMPs) such as TaAs, a class of noncentrosymmetric materials that heretofore received only limited attention \cite{XuScience2015, LvPRX2015, YangNatPhys2015}. The question that arises now is whether these materials will exhibit novel, enhanced, or technologically applicable electronic properties. The TMMPs are polar metals, a rare subset of inversion-breaking crystals that would allow spontaneous polarization, were it not screened by conduction electrons \cite{anderson1965symmetry,shi2013ferroelectric,kim2016polar}. Despite the absence of spontaneous polarization, polar metals can exhibit other signatures of inversion-symmetry breaking, most notably second-order nonlinear optical polarizability, $\chi^{(2)}$, leading to phenomena such as optical rectification and second-harmonic generation (SHG). Here we report measurements of SHG that reveal a giant, anisotropic $\chi^{(2)}$ in the TMMPs TaAs, TaP, and NbAs. With the fundamental and second harmonic fields oriented parallel to the polar axis, the value of $\chi^{(2)}$ is larger by almost one order of magnitude than its value in the archetypal electro-optic materials GaAs \cite{bergfeld2003second} and ZnTe \cite{wagner1998dispersion}, and in fact larger than reported in any crystal to date., Comment: Published in Nature Physics
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- 2016
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14. Multivariate approach in analyzing medical data with correlated multiple outcomes: An exploration using ACCORD trial data
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Mishra, Akash, Harichandrakumar, K.T., VS, Binu, Satheesh, Santhosh, and Nair, N. Sreekumaran
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- 2021
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15. A scoping review on barriers to case management of neonatal pneumonia in India
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Sreekumaran Nair, N., Edward Lewis, Leslie, Dhyani, Vijay Shree, Murthy, Shruti, Godinho, Myron, Lakiang, Theophilus, Pundir, Prachi, and Venkatesh, Bhumika T.
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- 2021
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16. Impact of Metacognitive Practices and Assorted Assessment Modalities towards Creating Self-Regulated Learners
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Nair N., Sreevrinda
- Abstract
Worldwide efforts are increasing to infuse thinking skills into the curriculum, which are part of cognitive behavior, and to include them in the instructional strategies, which will make the learner producer of knowledge and help to create a sense of responsibility among them. Metacognitive learning activities immerse students in challenging tasks and it creates a space for students to discuss, debate new ideas and allows them to introspect, assess and set targets for learning. The objectives of the study is aimed at implementing metacognitive practice, namely problem solving towards constructing a culture of thinking in classrooms and to capacitate the students to practice self-assessment modalities through the creation of a strategy evaluation proforma on the select classroom practice. 45 Secondary school students from three schools belonging to three districts of Kerala namely Pathanamthitta, Alappuzha and Kottayam were selected for the study. The data was collected through a Strategy Evaluation Proforma. The study reveals that highly participative and interactive instructional climate inculcated in the problem-solving practice allowed the students to strengthen their motivation towards becoming better problem solvers. The study also reveals that this type of assessment technique will enhance creative thoughts of students as well as promote their thinking capabilities in a worthy manner. Such type of enriched environment helps the students to flourish in the learning process and engage their brain with intriguing and inviting intellectual challenges.
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- 2014
17. A Stable Higher Order Space-Time Galerkin Scheme for Time Domain Integral Equations
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Pray, A. J., Beghein, Y., Nair, N. V., Cools, K., Bağcı, H., and Shanker, B.
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Physics - Computational Physics ,Mathematics - Numerical Analysis - Abstract
Stability of time domain integral equation (TDIE) solvers has remained an elusive goal for many years. Advancement of this research has largely progressed on four fronts: (1) Exact integration, (2) Lubich quadrature, (3) smooth temporal basis functions, and (4) Space-time separation of convolutions with the retarded potential. The latter method was explored in [Pray et al. IEEE TAP 2012]. This method's efficacy in stabilizing solutions to the time domain electric field integral equation (TD-EFIE) was demonstrated on first order surface descriptions (flat elements) in tandem with 0th order functions as the temporal basis. In this work, we develop the methodology necessary to extend to higher order surface descriptions as well as to enable its use with higher order temporal basis functions. These higher order temporal basis functions are used in a Galerkin framework. A number of results that demonstrate convergence, stability, and applicability are presented., Comment: 8 pages, 12 figures
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- 2014
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18. Completeness of reporting in Indian qualitative public health research : a systematic review of 20 years of literature
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Godinho, Myron Anthony, Gudi, Nachiket, Milkowska, Maja, Murthy, Shruti, Bailey, Ajay, and Nair, N. Sreekumaran
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- 2019
19. Observation of suppressed terahertz absorption in photoexcited graphene
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Frenzel, A. J., Lui, C. H., Fang, W., Nair, N. L., Herring, P. K., Jarillo-Herrero, P., Kong, J., and Gedik, N.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
When light is absorbed by a semiconductor, photoexcited charge carriers enhance the absorption of far-infrared radiation due to intraband transitions. We observe the opposite behavior in monolayer graphene, a zero-gap semiconductor with linear dispersion. By using time domain terahertz (THz) spectroscopy in conjunction with optical pump excitation, we observe a reduced absorption of THz radiation in photoexcited graphene. The measured spectral shape of the differential optical conductivity exhibits non-Drude behavior. We discuss several possible mechanisms that contribute to the observed low-frequency non-equilibrium optical response of graphene.
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- 2013
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20. On late-time stability of time domain integral equations for electromagnetics
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Nair, N. V., Pray, A. J., and Shanker, B.
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Mathematical Physics ,Mathematics - Numerical Analysis ,15A15, 15A09, 15A23 - Abstract
The problem of late time instability in time domain integral equations for electromagnetics is longstanding. While several techniques have been suggested for addressing this problem, they either require impractically high degrees of freedom in the basis function or an analytical computation of matrix elements. The authors recently proposed a method that demonstrates stability without requiring either of these. The paper, however, does not present theoretical foundations for the choice of, or a rigorous error bounds on the approximation of, the bilinear form. This paper complements the authors' previous work by presenting a construction of the bilinear form based on the minimization of the energy in the system and a proof for the bounds on the approximation. We present results on the bounds developed and few sample scattering results that demonstrate the stability of the proposed scheme.
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- 2012
21. Do Female Students Have Higher Motivation than Male Students in Learning of English at the Tertiary Level?
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Narayanan, R., Rajasekaran Nair, N., and Iyyappan, S.
- Abstract
There is a wide variety of factors such as: age, attitude, motivation, aptitude, amount of exposure, gender and anxiety etc in second language learning. These are also responsible for individual differences in learning a second (L2) / Foreign Language (FL). In social Psychology, it is a widely accepted fact that learner's individual differences have significant impact on the learner's overall L2/FL performance. That is why the major focus of the recent research in social psychology has been on various social psychological variables like, attitude, motivation, age, aptitude, anxiety, intelligence etc, and their impact on Second Language Acquisition (SLA). Gardner (1985) proposes that second language acquisition is truly a socio-psychological phenomenon. This paper focuses on gender differences affect the motivation factors towards learning of English as a second language among engineering and technology students. It also gives special emphasis on different motivation factors such as: integrative, instrumental, resultative and intrinsic with respect to gender differences. (Contains 5 tables and 1 figure.)
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- 2007
22. Stability Properties of the Time Domain Electric Field Integral Equation Using a Separable Approximation for the Convolution with the Retarded Potential
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Pray, A. J., Nair, N. V., and Shanker, B.
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Physics - Computational Physics - Abstract
The state of art of time domain integral equation (TDIE) solvers has grown by leaps and bounds over the past decade. During this time, advances have been made in (i) the development of accelerators that can be retrofitted with these solvers and (ii) understanding the stability properties of the electric field integral equation. As is well known, time domain electric field integral equation solvers have been notoriously difficult to stabilize. Research into methods for understanding and prescribing remedies have been on the uptick. The most recent of these efforts are (i) Lubich quadrature and (ii) exact integration. In this paper, we re-examine the solution to this equation using (i) the undifferentiated form of the TD-EFIE and (ii) a separable approximation to the spatio-temporal convolution. The proposed scheme can be constructed such that the spatial integrand over the source and observer domains is smooth and integrable. As several numerical results will demonstrate, the proposed scheme yields stable results for long simulation times and a variety of targets, both of which have proven extremely challenging in the past., Comment: 9 pages, 13 figures. To be published in IEEE Transactions on Antennas and Propagation
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- 2011
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23. Optimal Design of Fuzzy Based Power System Stabilizer Self Tuned by Robust Search Algorithm
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Linda, M. Mary and Nair, N. Kesavan
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Computer Science - Neural and Evolutionary Computing - Abstract
In the interconnected power system network, instability problems are caused mainly by the low frequency oscillations of 0.2 to 2.5 Hz. The supplementary control signal in addition with AVR and high gain excitation systems are provided by means of Power System Stabilizer (PSS). Conventional power system stabilizers provide effective damping only on a particular operating point. But fuzzy based PSS provides good damping for a wide range of operating points. The bottlenecks faced in designing a fuzzy logic controller can be minimized by using appropriate optimization techniques like Genetic Algorithm, Particle Swam Optimization, Ant Colony Optimization etc.In this paper the membership functions of FLC are optimized by the new breed optimization technique called Genetic Algorithm. This design methodology is implemented on a Single Machine Infinite Bus (SMIB) system. Simulation results on SMIB show the effectiveness and robustness of the proposed PSS over a wide range of operating conditions and system configurations.
- Published
- 2009
24. Feeding styles and adiposity in children of 6 months– 5 years of age: Protocol for a systematic review and meta- analysis
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Haridas, Divya Nair, primary, Schayck, Onno C. P. van, additional, Babu, Giridhar R., additional, Nair, N. Sreekumaran, additional, and Shriyan, Prafulla, additional
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- 2023
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25. RELIABILITY ASPECTS OF PROPORTIONAL MEAN RESIDUAL LIFE MODEL USING QUANTILE FUNCTIONS
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Nair, N. Unnikrishnan, Sankaran, P.G., and Sunoj, S.M.
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- 2019
26. Some Classes Of Distributions On The Non-Negative Lattice
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Satheesh, S. and Nair, N. Unnikrishnan
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Mathematics - Probability ,Mathematics - Statistics Theory ,60E05 ,60E07 ,60E10 ,60G50 ,62E10 ,62E15 ,62E20 - Abstract
A method for constructing distributions on the non negative integers as discrete analogue of continuous distributions on the non negative real is presented. A justification of the definition of discrete self decomposable laws is provided. Discrete analogue of distributions of the same type and the role of Bernoulli law in this context is discussed. Generalizations of some discrete laws and their properties are given. The geometric compounding problem for discrete distributions is studied by introducing discrete semi Mittag Leffler laws., Comment: 16 pages, in PDF format, two notes added at the end of the paper
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- 2003
27. Stability of Random Sums
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Satheesh, S., Nair, N. Unnikrishnan, and Sandhya, E.
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Mathematics - Probability ,Mathematics - Statistics Theory ,60E05 ,60E07 ,60E10 ,62E10 ,62E15 ,62E20 - Abstract
When the distribution of a random (N) sum of independent copies of a r.v X is of the same type as that of X we say that X is N-sum stable. In this paper we consider a generalization of stability of geometric sums by studying distributions that are stable under summation w.r.t Harris law. We show that the notion of stability of random sums can be extended to include the case when X is discrete. Finally we propose a method to identify the probability law of N for which X is N-sum stable. See also Satheesh and Nair (2002), (Some classes of distributions on ther non-negative lattice, J. Ind. Statist. Assoc., 2002, 40, 41-58) for a study of discrete laws of the same type and stability of geometric sums of discrete laws., Comment: 10 pages, in PDF format, a reference added in the abstract here
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- 2003
28. On the Stability of Geometric Extremes
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Satheesh, S. and Nair, N. Unnikrishnan
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Mathematics - Probability ,Mathematics - Statistics Theory ,60G70, 62H05, 62H10, 60E10 - Abstract
Possible reasons for the uniqueness of the positive geometric law in the context of stability of random extremes are explored here culminating in a conjecture characterizing the geometric law. Our reasoning comes closer in justifying the geometric law in similar contexts discussed in Arnold et al. (1986) and Marshall & Olkin (1997) and also supplement their arguments., Comment: 11 pages, in the published journal format, presented at the International Conference on Order Statistics and Extreme Values: Theory and Applications, December 18-20, 2000, University of Mysore, India
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- 2003
29. A Note on Maximum and Minimum Stability of Certain Distributions
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Satheesh, S. and Nair, N. U.
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Mathematics - Probability ,Mathematics - Statistics Theory ,60G70, 62H05, 62H10, 60E10 - Abstract
In the context of stability of the extremes of a random variable X with respect to a positive integer valued random variable N we discuss the cases (i) X is exponential (ii) non-geometric laws for N (iii) identifying N for the stability of a given X and (iv) extending the notion to a discrete random variable X., Comment: 4 pages, presented at the National Seminar on Probability Models and Applied Statistics, University of Calicut, February-2000
- Published
- 2003
30. ML328: A Novel Dual Inhibitor of Bacterial AddAB and RecBCD Helicase-nuclease DNA Repair Enzymes
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Thomas, Bannister D, Reji, Nair N, Timothy, Spicer, Vernilez, Vega F, C, Eberhart, B, Mercer A, Mike, Cameron, S, Schurer, S, Amundsen K, A, Karabulut, L, Londono M, Gerald, Smith R, and Peter, Hodder
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Community-Institutional Relations ,Hospices ,Hospitals ,Special ,Michigan ,Philosophy ,Medical ,Physicians - Published
- 2013
31. Mist net Capture and Field Observations on the Short nosed Fruit Bat (Chiroptera: Pteropodidae) Cynopterus Sphinx (Vahl.)
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Nathan, P T, Doss, D P Swami, Isaac, S S, Balasingh, J, Rajan, K Emmanuvel, Nair, N Gopukumar, Subbaraj, R, and BioStor
- Published
- 2001
32. Pooling of effect estimates obtained from various study designs in systematic reviews of public health interventions: A Bayesian approach to meta-analysis
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Lewis, Melissa Glenda, Guddattu, Vasudeva, Kamath, Asha, Biju, Seena, Noronha, Judith, Nayak, Baby, and Nair, N. Sreekumaran
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- 2017
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33. Seasonal Food Preference of the Indian Short Nosed Fruit Bat Cynopterus Sphinx(Vahl) (Chiroptera: Pteropodidae)
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Rajan, K Emmanuvel, Nair, N Gopukumar, Subbaraj, R, and BioStor
- Published
- 1999
34. Construction of Archimedean copulas using total time on test transforms.
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Nair, N. Unnikrishnan and Vineshkumar, B.
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ARCHIMEDEAN property ,COPULA functions ,RANK correlation (Statistics) ,ALGEBRAIC fields ,DISTRIBUTION (Probability theory) - Abstract
In the present work, we propose a method of constructing Archimedean copulas using the total time on test transform, extensively used in reliability modelling. It is observed that the copula can be specified in terms of a univariate life distribution with a finite mean and monotone hazard rate. We discuss some new properties of the Kendall distribution arising from the proposed new generator and the associated measures of dependence. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Baboon envelope pseudotyped lentiviral vectors efficiently transduce human B cells and allow active factor IX B cell secretion in vivo in NOD/SCIDγc‐/‐ mice
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Levy, C., Fusil, F., Amirache, F., Costa, C., Girard‐Gagnepain, A., Negre, D., Bernadin, O., Garaulet, G., Rodriguez, A., Nair, N., Vandendriessche, T., Chuah, M., Cosset, F‐L., and Verhoeyen, E.
- Published
- 2016
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36. Observations on morphology and the response of hyphae to temperature by Australian and French isolates of Lepista
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Stott, Karen, Broderick, Andrew, Nair, N G, BioStor, and BHL Australia
- Published
- 1997
37. Genome-wide Association Study of Methotrexate-Induced Liver Injury in Rheumatoid Arthritis Patients.
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Eektimmerman, F., Swen, J.J., Broeder, A.A. den, Hazes, J.M., Kurreeman, F.S., Verstappen, S.M.M., Nair, N., Pawlik, A., Nurmohamed, M.T., Dolžan, V., Böhringer, S., Allaart, C.F., Guchelaar, H.J., Eektimmerman, F., Swen, J.J., Broeder, A.A. den, Hazes, J.M., Kurreeman, F.S., Verstappen, S.M.M., Nair, N., Pawlik, A., Nurmohamed, M.T., Dolžan, V., Böhringer, S., Allaart, C.F., and Guchelaar, H.J.
- Abstract
01 april 2023, Item does not contain fulltext, Hepatotoxicity is a serious adverse drug reaction related to methotrexate (MTX). However, the cause of drug-induced liver injury (DILI) is still unclear and unpredictable. Genetic risk factors may predispose for MTX-DILI. Therefore, we conducted a nested case-control genome-wide association study to explore genetic risk factors associated with MTX-DILI. Seven international groups contributed blood samples and data of patients with rheumatoid arthritis who used MTX. MTX-DILI was defined as an alanine aminotransferase (ALT) level of at least three times the upper limit of normal (ULN), to increase contrast controls ALT levels did not raise above two times the ULN. Per study site, control subjects and patients with MTX-DILI (ratio 3:1) were matched for age, gender, and duration of MTX use. Patients were genotyped using Illumina GSA MD-24v1-0 and data were imputed using the 1000 Genomes reference panel. Single-nucleotide polymorphisms (SNPs) were analyzed using an additive genetic model, corrected for sex, country, and age. A P-value of ≤ 5 × 10(-8) was considered significant, whereas a P-value of ≤ 5 × 10(-6) was considered suggestive. A total of 108 MTX-DILI cases and 311 controls were included for association analysis. None of the SNPs were significantly associated with MTX-DILI. However, we found seven suggestive genetic variants associated with MTX-DILI (P-values 7.43 × 10(-8) to 4.86 × 10(-6) ). Of those, five SNPs were in the intronic protein-coding regions of FTCDNL1, BCOR, FGF14, RBMS3, and PFDN4/DOK5. Investigation of candidates SPATA9 (rs72783407), PLCG2 (rs60427389), RAVER2 (rs72675408), JAK1 (rs72675451), PTPN2 (rs2476601), MTHFR C677T (rs1801133), and into the HLA region did not show significant findings. No genetic variants associated with MTX-DILI were found, whereas suggestive SNPs need further investigation.
- Published
- 2023
38. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study
- Author
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van Essen, T, van Erp, I, Lingsma, H, Pisică, D, Yue, J, Singh, R, van Dijck, J, Volovici, V, Younsi, A, Kolias, A, Peppel, L, Heijenbrok-Kal, M, Ribbers, G, Menon, D, Hutchinson, P, Manley, G, Depreitere, B, Steyerberg, E, Maas, A, de Ruiter, G, Peul, W, Åkerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzó, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Castaño-León, A, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Čović, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Della Corte, F, Boogert, H, Đilvesi, Đ, Dixit, A, Donoghue, E, Dreier, J, Dulière, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubović, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kompanje, E, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovács, N, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Maegele, M, Majdan, M, Manara, A, Maréchal, H, Martino, C, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Mikolic, A, Misset, B, Muraleedharan, V, Murray, L, Nair, N, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyirádi, J, Oresic, M, Ortolano, F, Otesile, O, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Rădoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rehorčíková, V, Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnák, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schäfer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Kowark, A, Stevens, R, Stewart, W, Stocchetti, N, Sundström, N, Takala, R, Tamás, V, Tamosuitis, T, Taylor, M, Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Valeinis, E, Vallance, S, Vámos, Z, Van der Jagt, M, van der Naalt, J, Van der Steen, G, Van Hecke, W, van Heugten, C, Van Praag, D, Van Veen, E, van Wijk, R, Vyvere, T, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, von Steinbüchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylén, P, Zeiler, F, Ziverte, A, Zoerle, T, van Essen, Thomas A., van Erp, Inge A. M., Lingsma, Hester F., Pisică, Dana, Yue, John K., Singh, Ranjit D., van Dijck, Jeroen T. J. M., Volovici, Victor, Younsi, Alexander, Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter J. A., Manley, Geoffrey T., Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I. R., de Ruiter, Godard C. W., Peul, Wilco C., Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Van Veen, Ernest, van Wijk, Roel, Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K. W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, van Essen, T, van Erp, I, Lingsma, H, Pisică, D, Yue, J, Singh, R, van Dijck, J, Volovici, V, Younsi, A, Kolias, A, Peppel, L, Heijenbrok-Kal, M, Ribbers, G, Menon, D, Hutchinson, P, Manley, G, Depreitere, B, Steyerberg, E, Maas, A, de Ruiter, G, Peul, W, Åkerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzó, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Castaño-León, A, Cavallo, S, Chevallard, G, Chieregato, A, Citerio, G, Clusmann, H, Coburn, M, Coles, J, Cooper, J, Correia, M, Čović, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Della Corte, F, Boogert, H, Đilvesi, Đ, Dixit, A, Donoghue, E, Dreier, J, Dulière, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubović, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kompanje, E, Kondziella, D, Kornaropoulos, E, Koskinen, L, Kovács, N, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Maegele, M, Majdan, M, Manara, A, Maréchal, H, Martino, C, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Mikolic, A, Misset, B, Muraleedharan, V, Murray, L, Nair, N, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyirádi, J, Oresic, M, Ortolano, F, Otesile, O, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Pisica, D, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Rădoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rehorčíková, V, Helmrich, I, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnák, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schäfer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Kowark, A, Stevens, R, Stewart, W, Stocchetti, N, Sundström, N, Takala, R, Tamás, V, Tamosuitis, T, Taylor, M, Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Unterberg, A, Vajkoczy, P, Valeinis, E, Vallance, S, Vámos, Z, Van der Jagt, M, van der Naalt, J, Van der Steen, G, Van Hecke, W, van Heugten, C, Van Praag, D, Van Veen, E, van Wijk, R, Vyvere, T, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, von Steinbüchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylén, P, Zeiler, F, Ziverte, A, Zoerle, T, van Essen, Thomas A., van Erp, Inge A. M., Lingsma, Hester F., Pisică, Dana, Yue, John K., Singh, Ranjit D., van Dijck, Jeroen T. J. M., Volovici, Victor, Younsi, Alexander, Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter J. A., Manley, Geoffrey T., Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I. R., de Ruiter, Godard C. W., Peul, Wilco C., Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Van Veen, Ernest, van Wijk, Roel, Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K. W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Zeiler, Frederick A., Ziverte, Agate, and Zoerle, Tommaso
- Abstract
Background: Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation of traumatic acute subdural hematoma (ASDH) until the recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes of primary DC versus craniotomy. Methods: We conducted an analysis of centre treatment preference within the prospective, multicentre, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (known as CENTER-TBI) and NeuroTraumatology Quality Registry (known as Net-QuRe) studies, which enrolled patients throughout Europe and Israel (2014–2020). We included patients with an ASDH who underwent acute neurosurgical evacuation. Patients with severe pre-existing neurological disorders were excluded. In an instrumental variable analysis, we compared outcomes between centres according to treatment preference, measured by the case-mix adjusted proportion DC per centre. The primary outcome was functional outcome rated by the 6-months Glasgow Outcome Scale Extended, estimated with ordinal regression as a common odds ratio (OR), adjusted for prespecified confounders. Variation in centre preference was quantified with the median odds ratio (MOR). CENTER-TBI is registered with ClinicalTrials.gov, number NCT02210221, and the Resource Identification Portal (Research Resource Identifier SCR_015582). Findings: Between December 19, 2014 and December 17, 2017, 4559 patients with traumatic brain injury were enrolled in CENTER-TBI of whom 336 (7%) underwent acute surgery for ASDH evacuation; 91 (27%) underwent DC and 245 (63%) craniotomy. The proportion primary DC within total acute surgery cases ranged from 6 to 67% with an interquartile range (IQR) of 12–26% among 46 centres; the odds of receiving a DC for prognostically similar patients in one centre versus another randomly selected centre were
- Published
- 2023
39. Thrombolytics in VAD management — A single-center experience
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Nair, N., Schmitt, A.A., Rau, E.M., Anders, S., Sandler, D., and Icenogle, T.B.
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- 2016
- Full Text
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40. A tool to measure complexity in public health interventions: Its statistical properties and meta-regression approach to adjust it in meta-analysis
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Ravishankar, N. and Sreekumaran Nair, N.
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- 2016
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41. An overview of correlation and regression methods in medical research – An ophthalmologic perspective
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Nair, N. Sreekumaran, primary and Ganapathy, Sachit, additional
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- 2023
- Full Text
- View/download PDF
42. Adult immersion test for assessment of amitraz resistance in Rhipicephalus sanguineus ticks
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Reena, Shaik Nikhat, primary, Lakshmanan, Bindu, additional, Nair, N. Suresh, additional, Syamala, K., additional, Radhika, R., additional, Krishnanunni, P. K., additional, and Chandana, S. Devi, additional
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- 2023
- Full Text
- View/download PDF
43. Determination of the median lethal dose of indoxacarb pesticide in Wistar rat
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Raj, Archana, primary, Nair, N. Suresh, additional, Nisha, A.R., additional, Sujith, S., additional, Divya, C., additional, and Shankar, R., additional
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- 2023
- Full Text
- View/download PDF
44. Complexity in public health interventions – Stakeholders' perspective: A qualitative analysis
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Ravishankar, N., Lewis, Melissa Glenda, Mujja, Anusha, Nair, Suma, and Sreekumaran Nair, N.
- Published
- 2015
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- View/download PDF
45. Hospitalization in older patients due to adverse drug reactions – the need for a prediction tool
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Parameswaran Nair N, Chalmers L, Peterson GM, Bereznicki BJ, Castelino RL, and Bereznicki LR
- Subjects
adverse drug reactions ,hospital admission ,prediction ,older patients ,Geriatrics ,RC952-954.6 - Abstract
Nibu Parameswaran Nair, Leanne Chalmers, Gregory M Peterson, Bonnie J Bereznicki, Ronald L Castelino, Luke R Bereznicki Division of Pharmacy, School of Medicine, Faculty of Health, University of Tasmania, Hobart, TAS, Australia Abstract: Adverse drug reactions (ADRs) represent a major burden on society, resulting in significant morbidity, mortality, and health care costs. Older patients living in the community are particularly susceptible to ADRs, and are at an increased risk of ADR-related hospitalization. This review summarizes the available evidence on ADR-related hospital admission in older patients living in the community, with a particular focus on risk factors for ADRs leading to hospital admission and the need for a prediction tool for risk of ADR-related hospitalization in these individuals. The reported proportion of hospital admissions due to ADRs has ranged from 6% to 12% of all admissions in older patients. The main risk factors or predictors for ADR-related admissions were advanced age, polypharmacy, comorbidity, and potentially inappropriate medications. There is a clear need to design intervention strategies to prevent ADR-related hospitalization in older patients. To ensure the cost-effectiveness of such strategies, it would be necessary to target them to those older individuals who are at highest risk of ADR-related hospitalization. Currently, there are no validated tools to assess the risk of ADRs in primary care. There is a clear need to investigate the utility of tools to identify high-risk patients to target appropriate interventions toward prevention of ADR-related hospital admissions. Keywords: adverse drug reactions, hospital admission, prediction, older patients, primary care, risk factors
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- 2016
46. Assessment of Hepatobiliary Status and Cardiometabolic Risk Markers among Type 2 Diabetes Mellitus Patients. A Cross-Sectional Study
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Athar, Mohammad, primary, Ramesh, Ramasamy, additional, Vengatapathy, Kuzhandai Velu, additional, Kamalanathan, Sadishkumar, additional, and Nair, N. Sreekumaran, additional
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- 2022
- Full Text
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47. 191P Preliminary biomarker and safety results of SQZ-PBMC-HPV at RP2D in monotherapy and combination with checkpoint inhibitors in HLA A*02+ patients with recurrent, locally advanced, or metastatic HPV16+ solid tumors
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Jimeno, A., primary, Miselis, N.R., additional, Park, J.C., additional, Jennings, J., additional, Dhani, N., additional, Holtick, U., additional, Iams, W.T., additional, Rodabaugh, K., additional, Nair, N., additional, Kornacker, M., additional, Loughhead, S.M., additional, Bernstein, H., additional, Zwirtes, R., additional, Ji, R.R., additional, Warren, M., additional, and Sharei, A., additional
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- 2022
- Full Text
- View/download PDF
48. Магнітні наночастинки як регулятори ланцюгових структур в обертовому магнітному полі
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Nair, N., Jani, S., and Brajpuriya, R.
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магнітне поле ,magnetic fluid ,nanoparticles ,magnetic field ,магнітна рідина ,наночастинки - Abstract
Спостерігалося утворення ланцюга в магнітній рідині під впливом обертового магнітного поля. Вплив на гнучкість ланцюга та його розрив вивчався шляхом зміни частоти обертання (1-5 Гц) магнітного поля фіксованої величини (50 Гс). Частинки Fe3O4 мікрометрового розміру та немагнітні розширювальні сфери фіксованої концентрації пізніше окремо суспендували в магнітній рідині. Був вивчений їх вплив на динаміку обертання ланцюга. Установлено, що критична частота розриву ланцюга була вищою в присутності більших магнітних частинок порівняно з магнітною рідиною окремо. Немагнітні частинки утворювали ланцюгові структури в присутності статичного поля, але не реагували на обертання магнітного поля. Теорія утворення магнітного ланцюга була використана для вивчення та обговорення результатів шляхом порівняння магнітних сил і сил в’язкості. Дослідження може бути корисним для контролю довжини та гнучкості ланцюга в мікрогідродинаміці. Chain formation in magnetic fluid has been observed under the influence of a rotating magnetic field. The influence on the chain flexibility and its rupture was studied by varying the frequency of rotation (1-5 Hz) of the magnetic field of a fixed magnitude (50 Gauss). Micrometer sized Fe3O4 particles and nonmagnetic expancel spheres of fixed concentration were later suspended in the magnetic fluid separately and their effect on the chain rotation dynamics was studied. It was observed that the critical frequency for the chain breakage was higher in the presence of larger magnetic particles compared to magnetic fluid alone. Non-magnetic particles formed chain structures in the presence of a static field but did not show any response to the rotation of the magnetic field. The established theory of magnetic chain formation was used to study and discuss the results by comparing the magnetic forces and viscous forces. The study may be useful for controlling chain length and flexibility in microfluidics.
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- 2023
49. A Hybrid Digital Marketing Model based on Content Marketing and Inbound Marketing
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Harikrishnan, Nair N. J. and Vinith Kumar, Nair
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Digital marketing ,Big Data Analytics ,Content Marketing ,Inbound Marketing - Abstract
To assist marketing strategists in creating various marketing plans for different target markets, lower overhead costs, and boost the effectiveness of online advertising, the study aims to create an accurate and data-driven digital marketing platform. A Hybrid Digital Marketing Framework (HDMF) is designed in this research to combine the content marketing and inbound marketing strategy using big data analytics. This paper primarily introduces big data mining and related technologies, including the decentralized platform, the web browser, and key modules engaged. It explains these technical foundations, operational procedures, and e-commerce sites to present the main applications and implementation strategies. The particular example is chosen as the study object, and its implementation of marketing transformation concerning its particular scenario is examined with experimental results. The entire big data marketing procedure, from data collecting to data application, is executed and summed up through the product marketing effect presentation and outcomes analysis using content marketing and inbound marketing strategy.
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- 2022
50. Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study
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Sewalt C. A., Gravesteijn B. Y., Menon D., Lingsma H. F., Maas A. I. R., Stocchetti N., Venema E., Lecky F. E., Akerlund C., Amrein K., Andelic N., Andreassen L., Anke A., Antoni A., Audibert G., Azouvi P., Azzolini M. L., Bartels R., Barzo P., Beauvais R., Beer R., Bellander B. -M., Belli A., Benali H., Berardino M., Beretta L., Blaabjerg M., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Cabeleira M., Caccioppola A., Calappi E., Calvi M. R., Cameron P., Lozano G. C., Carbonara M., Chevallard G., Chieregato A., Citerio G., Cnossen M., Coburn M., Coles J., Cooper D. J., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Dawes H., De Keyser V., Degos V., Corte F. D., Boogert H., Depreitere B., Dilvesi D., Dixit A., Donoghue E., Dreier J., Duliere G. -L., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Foks K., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., George P., Ghuysen A., Giga L., Glocker B., Golubovic J., Gomez P. A., Gratz J., Gravesteijn B., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Helbok R., Helseth E., Horton L., Huijben J., Hutchinson P. J., Jacobs B., Jankowski S., Jarrett M., Jiang J. -Y., Jones K., Karan M., Kolias A. G., Kompanje E., Kondziella D., Koraropoulos E., Koskinen L. -O., Kovacs N., Lagares A., Lanyon L., Laureys S., Lecky F., Lefering R., Legrand V., Lejeune A., Levi L., Lightfoot R., Lingsma H., Castano-Leon A. M., Maegele M., Majdan M., Manara A., Manley G., Martino C., Marechal H., Mattern J., McMahon C., Melegh B., Menovsky T., Mulazzi D., Muraleedharan V., Murray L., Nair N., Negru A., Nelson D., Newcombe V., Nieboer D., Noirhomme Q., Nyiradi J., Olubukola O., Oresic M., Ortolano F., Palotie A., Parizel P. M., Payen J. -F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Pirinen M., Ples H., Polinder S., Pomposo I., Posti J. P., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Real R., Rhodes J., Richardson S., Richter S., Ripatti S., Rocka S., Roe C., Roise O., Rosand J., Rosenfeld J. V., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sahuquillo J., Sakowitz O., Sanchez-Porras R., Sandor J., Schafer N., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Sewalt C., Skandsen T., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Kowark A., Stevens R., Stewart W., Steyerberg E. W., Sundstrom N., Synnot A., Takala R., Tamas V., Tamosuitis T., Taylor M. S., Ao B. T., Tenovuo O., Theadom A., Thomas M., Tibboel D., Timmers M., Tolias C., Trapani T., Tudora C. M., Vajkoczy P., Vallance S., Valeinis E., Vamos Z., Van der Steen G., van der Naalt J., van Dijck J. T. J. M., van Essen T. A., Van Hecke W., van Heugten C., Van Praag D., Vyvere T. V., Vanhaudenhuyse A., van Wijk R. P. J., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Volovici V., von Steinbuchel N., Voormolen D., Vulekovic P., Wang K. K. W., Wiegers E., Williams G., Wilson L., Winzeck S., Wolf S., Yang Z., Ylen P., Younsi A., Zeiler F. A., Zelinkova V., Ziverte A., Zoerle T., Sewalt, Charlie Aletta [0000-0003-3270-4814], Apollo - University of Cambridge Repository, Public Health, Anesthesiology, Neurology, Amrein, Krisztina, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koraropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Andelic, Nada, Laureys, Steven, Lecky, Fiona, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I. R., Castaño-León, Ana M., Andreassen, Lasse, Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Anke, Audny, Menovsky, Tomas, Mulazzi, Davide, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Noirhomme, Quentin, Antoni, Anna, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Audibert, Gérard, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Azouvi, Philippe, Raj, Rahul, Rambadagalla, Malinka, Real, Ruben, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Azzolini, Maria Luisa, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Bartels, Ronald, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Barzó, Pál, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Beauvais, Romuald, Synnot, Anneliese, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Beer, Ronny, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, Van der Steen, Gregory, van der Naalt, Joukje, Bellander, Bo-Michael, van Dijck, Jeroen T. J. M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Vyvere, Thijs Vande, Vanhaudenhuyse, Audrey, van Wijk, Roel P. J., Vargiolu, Alessia, Vega, Emmanuel, Belli, Antonio, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K. W., Benali, Habib, Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederik A., Zelinkova, Veronika, Berardino, Maurizio, Ziverte, Agate, Zoerle, Tommaso, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Cnossen, Maryse, Coburn, Mark, Coles, Jonathan, Cooper, D. Jamie, Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Corte, Francesco Della, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Åkerlund, Cecilia, Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Molecular Neuroscience and Ageing Research (MOLAR), Ročka, Saulius, Tamošuitis, Tomas, CENTER TBI Participants Investigators, Section Neuropsychology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, „Springer Nature' grupė, Sewalt, C, Gravesteijn, B, Menon, D, Lingsma, H, Maas, A, Stocchetti, N, Venema, E, Lecky, F, Akerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzo, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Chevallard, G, Chieregato, A, Citerio, G, Cnossen, M, Coburn, M, Coles, J, Cooper, D, Correia, M, Covic, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dawes, H, De Keyser, V, Degos, V, Corte, F, Boogert, H, Depreitere, B, Dilvesi, D, Dixit, A, Donoghue, E, Dreier, J, Duliere, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Jones, K, Karan, M, Kolias, A, Kompanje, E, Kondziella, D, Koraropoulos, E, Koskinen, L, Kovacs, N, Lagares, A, Lanyon, L, Laureys, S, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Castano-Leon, A, Maegele, M, Majdan, M, Manara, A, Manley, G, Martino, C, Marechal, H, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Mulazzi, D, Muraleedharan, V, Murray, L, Nair, N, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Noirhomme, Q, Nyiradi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Peul, W, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Real, R, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnak, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schafer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Kowark, A, Stevens, R, Stewart, W, Steyerberg, E, Sundstrom, N, Synnot, A, Takala, R, Tamas, V, Tamosuitis, T, Taylor, M, Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Timmers, M, Tolias, C, Trapani, T, Tudora, C, Vajkoczy, P, Vallance, S, Valeinis, E, Vamos, Z, Van der Steen, G, van der Naalt, J, van Dijck, J, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, Vyvere, T, Vanhaudenhuyse, A, van Wijk, R, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbuchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylen, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, Zoerle, T, Sewalt, C. A., Gravesteijn, B. Y., Menon, D., Lingsma, H. F., Maas, A. I. R., Stocchetti, N., Venema, E., Lecky, F. E., Akerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzo, P., Beauvais, R., Beer, R., Bellander, B. -M., Belli, A., Benali, H., Berardino, M., Beretta, L., Blaabjerg, M., Bragge, P., Brazinova, A., Brinck, V., Brooker, J., Brorsson, C., Buki, A., Bullinger, M., Cabeleira, M., Caccioppola, A., Calappi, E., Calvi, M. R., Cameron, P., Lozano, G. C., Carbonara, M., Chevallard, G., Chieregato, A., Citerio, G., Cnossen, M., Coburn, M., Coles, J., Cooper, D. J., Correia, M., Covic, A., Curry, N., Czeiter, E., Czosnyka, M., Dahyot-Fizelier, C., Dawes, H., De Keyser, V., Degos, V., Corte, F. D., Boogert, H., Depreitere, B., Dilvesi, D., Dixit, A., Donoghue, E., Dreier, J., Duliere, G. -L., Ercole, A., Esser, P., Ezer, E., Fabricius, M., Feigin, V. L., Foks, K., Frisvold, S., Furmanov, A., Gagliardo, P., Galanaud, D., Gantner, D., Gao, G., George, P., Ghuysen, A., Giga, L., Glocker, B., Golubovic, J., Gomez, P. A., Gratz, J., Gravesteijn, B., Grossi, F., Gruen, R. L., Gupta, D., Haagsma, J. A., Haitsma, I., Helbok, R., Helseth, E., Horton, L., Huijben, J., Hutchinson, P. J., Jacobs, B., Jankowski, S., Jarrett, M., Jiang, J. -Y., Jones, K., Karan, M., Kolias, A. G., Kompanje, E., Kondziella, D., Koraropoulos, E., Koskinen, L. -O., Kovacs, N., Lagares, A., Lanyon, L., Laureys, S., Lecky, F., Lefering, R., Legrand, V., Lejeune, A., Levi, L., Lightfoot, R., Lingsma, H., Castano-Leon, A. M., Maegele, M., Majdan, M., Manara, A., Manley, G., Martino, C., Marechal, H., Mattern, J., Mcmahon, C., Melegh, B., Menovsky, T., Mulazzi, D., Muraleedharan, V., Murray, L., Nair, N., Negru, A., Nelson, D., Newcombe, V., Nieboer, D., Noirhomme, Q., Nyiradi, J., Olubukola, O., Oresic, M., Ortolano, F., Palotie, A., Parizel, P. M., Payen, J. -F., Perera, N., Perlbarg, V., Persona, P., Peul, W., Piippo-Karjalainen, A., Pirinen, M., Ples, H., Polinder, S., Pomposo, I., Posti, J. P., Puybasset, L., Radoi, A., Ragauskas, A., Raj, R., Rambadagalla, M., Real, R., Rhodes, J., Richardson, S., Richter, S., Ripatti, S., Rocka, S., Roe, C., Roise, O., Rosand, J., Rosenfeld, J. V., Rosenlund, C., Rosenthal, G., Rossaint, R., Rossi, S., Rueckert, D., Rusnak, M., Sahuquillo, J., Sakowitz, O., Sanchez-Porras, R., Sandor, J., Schafer, N., Schmidt, S., Schoechl, H., Schoonman, G., Schou, R. F., Schwendenwein, E., Sewalt, C., Skandsen, T., Smielewski, P., Sorinola, A., Stamatakis, E., Stanworth, S., Kowark, A., Stevens, R., Stewart, W., Steyerberg, E. W., Sundstrom, N., Synnot, A., Takala, R., Tamas, V., Tamosuitis, T., Taylor, M. S., Ao, B. T., Tenovuo, O., Theadom, A., Thomas, M., Tibboel, D., Timmers, M., Tolias, C., Trapani, T., Tudora, C. M., Vajkoczy, P., Vallance, S., Valeinis, E., Vamos, Z., Van der Steen, G., van der Naalt, J., van Dijck, J. T. J. M., van Essen, T. A., Van Hecke, W., van Heugten, C., Van Praag, D., Vyvere, T. V., Vanhaudenhuyse, A., van Wijk, R. P. J., Vargiolu, A., Vega, E., Velt, K., Verheyden, J., Vespa, P. M., Vik, A., Vilcinis, R., Volovici, V., von Steinbuchel, N., Voormolen, D., Vulekovic, P., Wang, K. K. W., Wiegers, E., Williams, G., Wilson, L., Winzeck, S., Wolf, S., Yang, Z., Ylen, P., Younsi, A., Zeiler, F. A., Zelinkova, V., Ziverte, A., Zoerle, T., Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, University of Helsinki, HUS Neurocenter, Neurokirurgian yksikkö, Statistical and population genetics, Biostatistics Helsinki, Clinicum, Helsinki University Hospital Area, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, and Complex Disease Genetics
- Subjects
medicine.medical_specialty ,Brain Injuries, Traumatic/diagnosis ,Referral ,IMPACT ,Traumatic brain injury ,traumatic brain injury ,referral ,transfer ,trauma system ,Glasgow Outcome Scale ,GUIDELINES ,Critical Care and Intensive Care Medicine ,3124 Neurology and psychiatry ,03 medical and health sciences ,0302 clinical medicine ,Case mix index ,Midline shift ,Brain Injuries, Traumatic ,medicine ,EPIDEMIOLOGY ,Humans ,In patient ,Glasgow Coma Scale ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Referral and Consultation ,Original Research ,OUTCOMES ,RC86-88.9 ,business.industry ,MORTALITY ,3112 Neurosciences ,HEAD-INJURY ,Medical emergencies. Critical care. Intensive care. First aid ,PREHOSPITAL MANAGEMENT ,Trauma system ,CARE ,3126 Surgery, anesthesiology, intensive care, radiology ,medicine.disease ,3. Good health ,Transfer ,Emergency medicine ,Emergency Medicine ,Human medicine ,business ,SYSTEM ,030217 neurology & neurosurgery - Abstract
Scandinavian journal of trauma, resuscitation and emergency medicine 29(1), 113 (2021). doi:10.1186/s13049-021-00930-1, Published by BioMed Central, London
- Published
- 2021
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