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4. Implementation of an organized colorectal cancer screening program through quantitative fecal immunochemical test followed by colonoscopy in an urban low-income community: Guidance and strategies

Author

Ribeiro, Ulysses, Jr., Safatle-Ribeiro, Adriana Vaz, Sorbello, Maurício, Kishi, Poliana Helena Rosolem, Cohend, Diane Dede, Mattar, Rejane, Castilho, Vera Lucia Pagliusi, Goncalves, Elenice Messias Do Nascimento, Kawaguti, Fábio, Marques, Carlos Frederico Sparapan, Alves, Venâncio Avancini Ferreira, Nahas, Sérgio Carlos, and Eluf-Neto, José

Published
2023
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17. A Head-to-Head Comparison of Computed Tomography Colonography, Optical Colonoscopy, and Colon Endoscopic Capsule for the Detection of Polyps After Partial Colectomy or Rectosigmoidectomy for Colorectal Cancer: A Pilot Study

Author

Sakai, Christiano Makoto, primary, Ueda, Serli Kiyomi Nakao, additional, Caiado, Angela Hissae Motoyama, additional, Ribeiro, Igor Braga, additional, Marinho, Fabio Ramalho Tavares, additional, de Rezende, Daniel Tavares, additional, Bustamante-Lopez, Leonardo A, additional, Nahas, Sergio C, additional, de Moura, Diogo Turiani Hourneaux, additional, and de Moura, Eduardo Guimarães Hourneaux, additional

Published
2023
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18. Predictive factors of response to infliximab therapy in Brazilian inflammatory bowel disease patients.

Author

Martins, Camilla de Almeida, Azevedo, Matheus Freitas Cardoso de, Carlos, Alexandre Sousa, Damião, Aderson Omar Mourão Cintra, Sobrado Junior, Carlos Walter, Nahas, Sergio Carlos, and Queiroz, Natália Sousa Freitas

Subjects
INFLAMMATORY bowel diseases, CROHN'S disease, DISEASE remission, ULCERATIVE colitis, TREATMENT duration, C-reactive protein
Abstract

Background: Biological therapies have revolutionized the treatment of patients with inflammatory bowel disease (IBD). Infliximab (IFX) has been shown to be effective in inducing and maintaining remission in patients with Crohn's disease and ulcerative colitis. However, about one-third of the patients are primary non-responders, and up to half can lose response over time. Hence, it is important to assess which factors are related to treatment failure. Objectives: We aimed to identify factors predicting clinical and endoscopic remission with IFX treatment during maintenance therapy in a Brazilian IBD referral center. Design: We conducted a cross-sectional study to describe demographic, clinical, and IBD therapy-related characteristics of IBD patients treated with IFX for at least 6 months in a Brazilian referral center. Subsequently, we evaluated factors associated with clinical and endoscopic remission (primary and secondary outcomes, respectively). Methods: We used descriptive statistics to summarize the essential demographic and clinical characteristics of the population. The association of sociodemographic and clinical variables with outcomes was analyzed using multivariable logistic regression. Results: A total of 131 IBD patients (the mean age 41.7 years) were enrolled in this study. Clinical and endoscopic remission were observed in 79.4% and 58.2% of the patients, respectively. In the multivariable analysis, IFX therapy duration and higher albumin levels increased the likelihood of clinical remission, while previous surgery decreased its chance. Prior use of adalimumab and higher C-reactive protein levels reduced the likelihood of endoscopic remission. Conclusion: In summary, this study has enhanced our understanding of the predictive factors of treatment response to IFX in a well-characterized Brazilian IBD population. Trial registration: 4.254.501 and 2.903.748. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Impact of microsatellite status in early-onset colonic cancer

Author

Zaborowski, Alexandra M., Adamina, Ahmed Abdile. Michel, Aigner, Felix, D'Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Bach, Sam Atallah Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D., Buchwald, Pamela, Burger, Jacobus W. A., Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Collinson, Rowan, Cologne, Kyle G., Contreras, Tomas, Croner, Roland, Daniels, Ian R., Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D'Hoore, Andre, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, el-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Figueiredo, Nuno, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Goran, Barisic, Greenwood, Emma, Guren, Marianne G., Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah D., Salido, Andrea Jimenez, Jimenez-Toscano, Marta, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A., Keller, Deborah S., Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Peter, Koh, Cherry, Kok, Neils, Knight, Katrina A., Knol, Joep, Kontovounisios, Christos, Korner, Hartwig, Krivokapic, Zoran, Kronberger, Irmgard, Kroon, Hidde Maarten, Kryzauskas, Marius, Kural, Said, Kusters, Miranda, Lakkis, Zaher, Lankov, Timur, Larson, David, Lázár, György, Lee, Kai-Yin, Lee, Suk Hwan, Lefèvre, Jeremie H., Lepisto, Anna, Lieu, Christopher, Loi, Lynette, Lynch, Craig, Maillou-Martinaud, Helene, Maroli, Annalisa, Martin, Sean, Martling, Anna, Matzel, Klaus E., Mayol, Julio, McDermott, Frank, Meurette, Guillaume, Millan, Monica, Mitteregger, Martin, Moiseenko, Andrei, Monson, John Rt., Morarasu, Stefan, Moritani, Konosuke, Möslein, Gabriela, Munini, Martino, Nahas, Caio, Nahas, Sergio, Negoi, Ionut, Novikova, Anastasia, Ocares, Misael, Okabayashi, Koji, Olkina, Alexandra, Oñate-Ocaña, Luis, Otero, Jaime, Ozen, Cihan, Pace, Ugo, Julião, Guilherme Pagin S. o, Panaiotti, Lidiia, Panis, Yves, Papamichael, Demetris, Patel, Swati, Uriburu, Juan Carlos Patrón, Peng, Sze-Lin, Pera, Miguel, Perez, Rodrigo O., Petrov, Alexei, Pfeffer, Frank, Phang, Terry P., Poskus, Tomas, Pringle, Heather, Proud, David, Raguz, Ivana, Rama, Nuno, Rasheed, Shahnawaz, Raval, Manoj J., Rega, Daniela, Reissfelder, Christoph, Meneses, Juan Carlos Reyes, Ris, Frederic, Riss, Stefan, Rodriguez-Zentner, Homero, Roxburgh, Campbell S., Saklani, Avanish, Sammour, Tarik, Saraste, Deborah, Schneider, Martin, Seishima, Ryo, Sekulic, Aleksandar, Seppala, Toni, Sheahan, Kieran, Shlomina, Alexandra, Sigismondo, Guiseppe, Singnomklao, Tongplaew, Siragusa, Leandro, Smart, Neil, Solis-Peña, Alejandro, Spinelli, Antonino, Staiger, Roxane D., Stamos, Michael J., Steele, Scott, Tan, Ker-Kan, Tanis, Pieter J., Tekkis, Paris, Teklay, Biniam, Tengku, Sabrina, Tsarkov, Petr, Turina, Matthias, Ulrich, Alexis, Vailati, Bruna B., van Harten, Meike, Verhoef, Cornelis, Warrier, Satish, Wexner, Steven, de Wilt, Hans, Weinberg, Benjamin A., Wells, Cameron, Wolthuis, Albert, Xynos, Evangelos, You, Nancy, Zakharenko, Alexander, Zeballos, Justino, Zhou, Jonathan, Winter, Des C., CCA - Cancer Treatment and Quality of Life, Surgery, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and nuclear medicine, and CCA - Cancer Treatment and quality of life

Subjects
Proto-Oncogene Proteins B-raf, Microsatellite Repeats/genetics, Colonic Neoplasms/genetics, Prognosis, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins p21(ras)/genetics, SDG 3 - Good Health and Well-being, Colonic Neoplasms, Mutation, Proto-Oncogene Proteins B-raf/genetics, Humans, Microsatellite Instability, Surgery, 03.02. Klinikai orvostan, Colorectal Neoplasms, Microsatellite Repeats
Abstract

Background The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods Anonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I–III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated. Results A total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively). Conclusion Patients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.

Published
2022
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28. AMPUTAÇÃO ABDOMINOPERINEAL DE RETO COM TEMPO PERINEAL EM POSIÇÃO PRONA: VÍDEO COM ÊNFASE EM ASPECTOS TÉCNICOS DA PRONAÇÃO DO PACIENTE

Author

Cirenza, Caroline de Freitas, additional, Arabi, Arthur Youssif Mota, additional, Baca, John Aníbal Tapia, additional, Averbach, Pedro, additional, Simões, ítalo Beltrão Pereira, additional, Imperiale, Antonio Rocco, additional, Nahas, Sergio Carlos, additional, and Marques, Carlos Frederico Sparapan, additional

Published
2022
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32. FÍSTULA RETONEOVAGINAL: TRATAMENTO CIRÚRGICO

Author

Cirenza, Caroline de Freitas, additional, Simões, ítalo Beltrão Pereira, additional, Caiado, André Filipe Jerónimo de Jesus, additional, Hora, Jose Americo Bacchi, additional, Nahas, Sergio Carlos, additional, and Marques, Carlos Frederico Sparapan, additional

Published
2022
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33. AVALIAÇÃO DOS RESULTADOS ONCOLÓGICOS E DOS FATORES PROGNÓSTICOS EM PACIENTES COM CÂNCER DE RETO SUBMETIDOS A QUIMIORRADIOTERAPIA NEOADJUVANTE E EXCISÃO TOTAL DO MESORRETO

Author

Nahas, Caio Sergio Rizkallah, additional, Marques, Carlos Frederico Sparapan, additional, Junior, Ulysses Ribeiro, additional, Cotti, Guilherme Cutait, additional, Imperiale, Antonio Rocco, additional, Pinto, Rodrigo Ambar, additional, Cirenza, Caroline, additional, and Nahas, Sergio Carlos, additional

Published
2022
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36. A CROMOENDOSCOPIA COM MAGNIFICAÇÃO SELECIONA NEOPLASIAS RETAIS PASSÍVEIS DE RESSECÇÃO LOCAL DE FORMA MAIS ACURADA DO QUE A RESSONÂNCIA MAGNÉTICA

Author

Kimura, Cintia Mayumi Sakurai, additional, Kawaguti, Fabio Shiguehissa, additional, Nahas, Caio Sergio Rizkallah, additional, Marques, Carlos Frederico S., additional, Cirenza, Caroline de Freitas, additional, Pinto, Rodrigo Ambar, additional, Safatle-Ribeiro, Adriana Vaz, additional, and Nahas, Sergio Carlos, additional

Published
2022
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37. IMPACTO DA PRESENÇA DE FORMA ROTINEIRA DA DISSECÇÃO ENDOSCÓPICA DA SUBMUCOSA NO MANEJO DE LESÕES COLORRETAIS NÃO MALIGNAS TRATADAS EM UM CENTRO DE REFERÊNCIA DE CÂNCER

Author

Kawaguti, Fabio Shiguehissa, additional, Kimura, Cintia Mayumi Sakurai, additional, Nahas, Sergio Carlos, additional, Safatle-Ribeiro, Adriana Vaz, additional, Nahas, Caio Sergio Rizkallah, additional, Cirenza, Caroline de Freitas, additional, and Marques, Carlos Frederico Sparapan, additional

Published
2022
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39. Hexafluoroisopropanol decreases liver ischemia–reperfusion injury by downregulation of high mobility group box‐1 protein

Author

Vintimilla Moscoso, Agustin, primary, Figueira, Estela Regina Ramos, additional, Rocha‐Filho, Joel Avancini, additional, Urner, Martin, additional, Lanchotte, Cinthia, additional, Jukemura, Jose, additional, Ximenes, Jorge Luiz Saraiva, additional, Nahas, Sergio Carlos, additional, D'Albuquerque, Luiz Augusto Carneiro, additional, and Galvao, Flavio Henrique Ferreira, additional

Published
2022
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40. Gastric and Duodenal Fistulas in Crohn's Disease, a Surgical Challenge: Report of 5 Cases and a Review of the Literature.

Author

Walter Sobrado Junior, Carlos, de Moura Villela Junior, Helder, Graciolli Facanali, Carolina Bortolozzo, Faraco Sobrado, Lucas, Monteiro de Camargo, Mariane Gouvea, and Carlos Nahas, Sergio

Subjects
CROHN'S disease, GASTRIC fistula, LITERATURE reviews, FISTULA, ANAL diseases, ILEITIS, INFECTION control
Abstract

Objective: Rare disease Background: Fistulas involving the stomach and duodenum in Crohn's disease are rare (occurring in less than 1% of patients). Here, we reviewed registers from 855 patients with Crohn's disease treated in our service from January 2007 to December 2020 and found 4 cases of duodenal fistula and 1 case of gastric fistula. Case Reports: The fistula origin was in the ileocolic segment in all cases, and all of the patients underwent preoperative optimization with improvement of nutritional status and infection control. They then underwent surgical treatment with resection of the affected segment and duodenal or gastric closure with covering by an omental patch. One case of a duodenal fistula was complicated by duodenal dehiscence. This was treated surgically with duodenojejunostomy. Each of the other patients had an uneventful postoperative course. All patients were successfully cured of their gastroduodenal fistulas, and at the time of this publication, none of them died or had fistula recurrence. Conclusions: Fistulas with the involvement of the stomach and duodenum in patients with Crohn's disease are almost always due to inflammation in the ileum, colon, or previous ileocolic anastomosis. Management of this situation is complex and often requires clinical and surgical assistance; preoperative optimization of the patient's general condition can improve the surgical results. The surgical approach is based on resection of the affected segment and gastric or duodenal closure with covering by an omental patch. Gastrojejunostomy or duodenojejunostomy can be performed in selected patients with larger defects and minor jejunal disease. To prevent recurrence, prophylactic therapy with anti-TNF agents and early endoscopic surveillance are also essential for successful treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Use of an electromagnetic-guided device to assist with post-pyloric placement of a nasoenteral feeding tube: A systematic review and meta-analysis

Author

Mancini, Fabio Catache, additional, de Moura, Diogo Turiani Hourneaux, additional, Funari, Mateus Pereira, additional, Ribeiro, Igor Braga, additional, Neto, Fernando Lopes Ponte, additional, Mendieta, Pastor Joaquin Ortiz, additional, McCarty, Thomas R., additional, Bernardo, Wanderley Marques, additional, Nahas, Sergio Carlos, additional, and de Moura, Eduardo Guimarães Hourneaux, additional

Published
2022
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43. RESULTS OF SURGICAL TREATMENT OF COLORECTAL CANCER, ELECTIVE AND EMERGENCY, IN PATIENTS WITH COVID-19

Author

NAHAS, Sergio Carlos, MEIRA JÚNIOR, José Donizeti de, NAHAS, Caio Sergio Rizkallah, SOBRADO, Lucas Faraco, PINTO, Rodrigo Ambar, ABDALA, Edson, RIBEIRO JUNIOR, Ulysses, and CECCONELLO, Ivan

Subjects
Coronavirus, Neoplasias do Colo.Cirurgia Colorretal, Pandemia, Covid-19. Coronavirus. Pandemic. Colonic Neoplasms. Colorectal Surgery. Abdomen, Abdome Agudo, Covid-19, Acute
Published
2022

46. 1022: THE ROLE OF PROBE-BASED CONFOCAL ENDOMICROSCOPY (PCLE) IN THE DIAGNOSIS OF SUSTAINED CLINICAL COMPLETE RESPONSE UNDER WATCH-AND-WAIT STRATEGY AFTER NEOADJUVANT CHEMORADIOTHERAPY FOR LOCALLY ADVANCED RECTAL ADENOCARCINOMA

Author

Safatle-Ribeiro, Adriana V., primary, Lata, John, additional, Ferreira, Marina Tucci Gammaro Baldavira, additional, Flor, Marcelo M., additional, Perez, Caio, additional, Baba, Elisa R., additional, Lenz, Luciano H., additional, Martins, Bruno Da Costa, additional, Kawaguti, Fabio S., additional, Paulo, Gustavo A. De, additional, Lima, Marcelo S. De, additional, Moura, Renata N., additional, Pennacchi, Caterina, additional, Gusmon, Carla, additional, Geiger, Sebastian, additional, Uemura, Ricardo, additional, Nahas, Caio Sergio R., additional, Marques, Carlos F., additional, Imperiale, Antonio R., additional, Cotti, Guilherme C., additional, Ribeiro, Ulysses, additional, Maluf-Filho, Fauze, additional, and Nahas, Sergio C., additional

Published
2022
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50. 628: SHORT-TERM SURGICAL OUTCOMES OF ROBOTIC GASTRECTOMY COMPARED TO OPEN GASTRECTOMY FOR PATIENTS WITH GASTRIC CANCER: A RANDOMIZED TRIAL

Author

Ribeiro, Ulysses, primary, Dias, Andre Roncon, additional, Ramos, Marcus F., additional, Yagi, Osmar K., additional, Oliveira, Rodrigo J. De, additional, Abdalla, Ricardo Z., additional, Pereira, Marina A., additional, Zilberstein, Bruno, additional, Nahas, Sergio C., additional, and Cecconello, Ivan, additional

Published
2022
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