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Digital literacy among undergraduate student is very important, because in the current digital era, the younger generation is expected to be able to master digital literacy for various benefits for learning and their future. The objective of this paper is to identify the success factors for enhancing digital literacy among undergraduate students. To address this issue, we used PRISMA flowchart, which offers a methodological framework and reporting procedure for the current review. There were 20 articles which reviewed in this paper. These findings show that seven main factors have emerged to answer the objective of this study, namely digital knowledge, communication skill, collaboration skill, ICT infrastructure, social environment, social media, and learning activity. This paper is expected to foster the interest of other researchers and reveal other factors that can influence factors for enhancing digital literacy among undergraduate students, because many other factors can also be raised in research on digital literacy in the world of education.

Knowledge-based economy is an economic model students need to be prepared for a future economic model that uses knowledge as its main resource. Therefore, this study developed and validated instruments for constructing knowledge-based economy readiness among undergraduate students. This study used an online questionnaire with 120 respondents of economic education students in educational universities in East Java, Indonesia, for exploratory factor analysis and 417 respondents for confirmatory factor analysis. Then, statistical analysis was conducted using exploratory factor analysis in SPSS and confirmatory factor analysis in AMOS. This study first developed five factors of knowledge of economics, readiness for economic challenges, readiness for education, readiness for infrastructure, and readiness for innovation, consisting of 27 items. However, one item was removed because the loading factor was below 0.50. Consequently, 26 items were retained because the loading factor was significantly greater than 0.50. The Cronbach's alpha value for each item of the knowledge-based economy readiness construct was >0.60 and met all goodness of fit index criteria, which means that it meets the requirements and can measure the construct of knowledge-based economy readiness. Since this study meets the validity and reliability requirements of the constructs leading to knowledge-based economy readiness, these results will help students prepare for the current and future knowledge-based economy. They can be used in developing economic education curricula in higher education.

Introduction: Fasting denotes abstinence from food or drink or both for well-being, ritualistic, and spiritual purposes. This study was conducted to explore the effect of Navratras fasting on anthropometric parameters, biochemical factors, and pro-inflammatory biomarkers. Materials and Methods: This study was a short-term longitudinal follow-up study conducted during Navratras (Oct 2020) in a residential medical college campus in western Maharashtra. Assessment of the participants based on anthropometry, biochemical, and pro-inflammatory markers was done at three-time points 7 days before the start of intermittent fasting (T1) (before the start of Navratras), at the end of intermittent fasting (the last day of the festival) (T2) (during Navratras), and 1 week after completion of intermittent fasting (T3) (after the end of Navratras). Results: A total of 50 subjects participated in the study, and the mean age of study participants was 33.6 ± 10 years. There was a significant reduction in body weight (P = 0.001), waist circumference (P = 0.001), and hip circumference (P ≤ 0.05) during the intermittent fasting period (T2). Significantly lower levels of total cholesterol (P < 0.01) and low density lipoprotein (LDL) (P < 0.01) were observed in the T2 and T3 time points of sampling. However, a significant increase in TNF-alpha, IL-1, IL-6, and IL-8 levels was observed during the T2 phase (P < 0.001). Conclusion: The current exploratory study evaluating the importance of intermittent fasting during Navratras showed a significant reduction in certain anthropometric as well as biochemical parameters. It is recommended that intermittent fasting may be considered by individuals who are overweight and need to improve overall health. However, it is important that like any other weight-loss program, intermittent fasting should also be undertaken under medical supervision.

AbstractSoil-transmitted helminth (STH) among children aged 24–59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case–control data was conducted in Bandung district from October 2019 to January 2023. Sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed. Statistical analysis was performed to evaluate the prevalence and association of 25(OH)D, IL-4, IL-5, and IL-13 with the burden of STH infection in stunted children. In total, 401 stunted children were recruited. A higher burden of STH infection was found for lower levels of IL-5 (r = −0.477; p = 0.004) and IL-13 (r = −0.433; p = 0.028). Thus, 25(OH)D, IL-4, IL-5, and IL-13 play a role in the burden of STH infection.

In cell models, changes in the 'accessible' pool of plasma membrane (PM) cholesterol are linked with the regulation of endoplasmic reticulum sterol synthesis and metabolism by the Aster family of nonvesicular transporters; however, the relevance of such nonvesicular transport mechanisms for lipid homeostasis in vivo has not been defined. Here we reveal two physiological contexts that generate accessible PM cholesterol and engage the Aster pathway in the liver: fasting and reverse cholesterol transport. During fasting, adipose-tissue-derived fatty acids activate hepatocyte sphingomyelinase to liberate sequestered PM cholesterol. Aster-dependent cholesterol transport during fasting facilitates cholesteryl ester formation, cholesterol movement into bile and very low-density lipoprotein production. During reverse cholesterol transport, high-density lipoprotein delivers excess cholesterol to the hepatocyte PM through scavenger receptor class B member 1. Loss of hepatic Asters impairs cholesterol movement into feces, raises plasma cholesterol levels and causes cholesterol accumulation in peripheral tissues. These results reveal fundamental mechanisms by which Aster cholesterol flux contributes to hepatic and systemic lipid homeostasis.

Choriocarcinoma occurs mainly in the gonads, but an extragonadal origin has been reported, albeit infrequently. Primary hepatic choriocarcinoma (PHC) is a rare malignancy, with only 11 cases reported. Most cases reported were in males, with none reported in pregnant females. A 23-year-old primigravida presented with a large liver lesion involving the right lobe of the liver at 28 weeks of pregnancy. Preoperative imaging was suggestive of hepatocellular carcinoma. She underwent a non-anatomical resection of the liver lesion. Surprisingly, her postoperative histopathology revealed a diagnosis of PHC. Her blood workup showed elevated beta human chorionic gonadotrophin. She underwent a termination of her pregnancy at 32 weeks. Before initiating adjuvant chemotherapy four weeks after surgery, a whole-body PET scan revealed multiple bi-lobar liver and pelvic deposits. After a multidisciplinary team discussion, she was started on adjuvant chemotherapy. She is currently under regular follow-up, seven months post-surgery. PHC, one of the vascular lesions of the liver, poses a diagnostic and therapeutic challenge, warranting a multidisciplinary approach.

Regulation of hepatocyte proliferation and liver morphology is of critical importance to tissue and whole-body homeostasis. However, the molecular mechanisms that underlie this complex process are incompletely understood. Here, we describe a role for the ubiquitin ligase BRCA1-associated protein (BRAP) in regulation of hepatocyte morphology and turnover via regulation of MST2, a protein kinase in the Hippo pathway. The Hippo pathway has been implicated in the control of liver morphology, inflammation, and fibrosis. We demonstrate here that liver-specific ablation of Brap in mice results in gross and cellular morphological alterations of the liver. Brap-deficient livers exhibit increased hepatocyte proliferation, cell death, and inflammation. We show that loss of BRAP protein alters Hippo pathway signaling, causing a reduction in phosphorylation of YAP and increased expression of YAP target genes, including those regulating cell growth and interactions with the extracellular environment. Finally, increased Hippo signaling in Brap knockout mice alters the pattern of liver lipid accumulation in dietary models of obesity. These studies identify a role for BRAP as a modulator of the hepatic Hippo pathway with relevance to human liver disease.

This study analyses the impact of intellectual capital disclosure on the firm's financial performance by developing a comprehensive intellectual capital disclosure index. The study reveals that although intellectual capital disclosure has an insignificant impact on the return on assets, it positively impacts the firm's market capitalization. Among the components of intellectual capital disclosure, Structural capital and Relational capital disclosure positively contribute to the relationship, while Human capital disclosure negatively impacts firm performance. These insights can aid firms in making strategic decisions regarding intellectual capital management and disclosure practices, potentially leading to improved firm performance. The originality of our study lies in the fact that while the literature on this relationship is scarce, with no study in the Indian context, our study provides a realistic conclusion to the intellectual capital disclosure-firm performance relationship and adds value to the current intellectual capital-driven competitive market.

Akibat dari pandemi Covid-19 yang semakin memburuk, dunia pendidikan telah mengadopsi distance learning demi mewujudkan penjagaan social distancing serta mengurangi intensitas mobilisasi penduduk. Hadirnya berbagai konten video pembelajaran tentu menjadi alternatif pendukung aktivitas belajar siswa, tidak terkecuali para siswa dari disiplin ilmu Akuntansi. Penelitian ini bertujuan mengembangkan Happy Teaching Video Series sebagai upaya optimalisasi distance learning pada matakuliah Strategi Belajar Mengajar Akuntansi. Happy Teaching Video Series dikembangkan dengan didasarkan pada elemen-elemen cognitive load, student engagement, dan active learning yang digagas oleh Brame (2016) sebagai elemen-elemen yang menentukan efektifitas dari sebuah video pembelajaran. Hadirnya Happy Teaching Video Series dapat dijadikan contoh impelementasi untuk mengembangkan media pembelajaran, khususnya untuk ilmu akuntansi yang dipersepsikan sebagai subjek yang praktikal dan cenderung sulit dimata para siswa.

Pelatihan Sistem Pertanian Terpadu di Desa Sumberahayu, melalui Program Penguatan Kapasitas Organisasi Kemahasiswaan BEM FPMIPATI UPGRIS, mewakili upaya kolaboratif untuk mendorong pertanian berkelanjutan dan partisipatif di tingkat desa. Pelatihan ini menggabungkan pengetahuan akademis mahasiswa dengan pengalaman praktis petani dalam mengintegrasikan aspek pertanian, peternakan, dan lingkungan. Fokus utama adalah memberdayakan masyarakat desa melalui pendidikan, pelatihan, dan aksi nyata. Mahasiswa sebagai agen perubahan memainkan peran sentral dalam menyampaikan pengetahuan tentang pertanian terpadu kepada petani. Melalui pendekatan partisipatif, mereka memfasilitasi diskusi, demonstrasi lapangan, dan interaksi yang memungkinkan transfer pengetahuan yang efektif. Sementara itu, pelatihan ini juga memperkuat peran organisasi kemahasiswaan sebagai jembatan antara universitas dan masyarakat desa. Pengukuran hasil keberhasilan menggunakan pre test dan post test yang akan dideskripsikan. Hasilnya, masyarakat Desa Sumberahayu mengalami peningkatan kemampuan dan pengetahuan mengenai pelatihan sistem pertanian terpadu.

Solitary fibrous tumors (SFTs) are an uncommon group of neoplasms. The visceral pleura is the most common site of origin of these tumors. The colonic mesentery is an unusual site of origin of SFTs. A pre-operative diagnosis of SFT is challenging as there are no pathognomonic clinical or radiological signs. Most patients reported thus far were diagnosed post-operatively with the aid of immunohistochemical markers. Complete surgical excision is the treatment of choice for SFTs. Recurrences are uncommon. However, they can occasionally show aggressive behavior. In this report, we describe two cases of rare colonic mesentery SFTs.

Micro, Small and Medium Enterprises (MSMEs) in the Banjaran Unit area of Guwosari District, Bantul, Yogyakarta, which are engaged in the culinary business, became collaborators in this activity. MSMEs have problems in the marketing process which is still very basic and conventional, and lack of understanding of financial records. Thus, the author offers guidance on how to manage digital media effectively, as well as how to create financial reports and business accounts on platforms such as Instagram and Linktree and ledgers as a financial recording site. The technique used is a qualitative approach based on outreach, discussion, and providing instructions on how to register an account on digital media and manage the account. The results of this activity indicate that periodic assistance is necessary so that digital marketing tactics can be used effectively and optimally in assisting marketing efforts and boosting sales to MSME companies. Suggestions were made by the activity implementing team so that more MSMEs would receive assistance on the benefits of digital marketing for their businesses. This will be very helpful in encouraging an understanding of digital marketing regarding the steps taken, creating and managing social media applications more optimally for business development.

Today, academic institution involves digital data to support the educational process. It has advantages, especially related to ease of access and process. However, security problems appear related to digital data. There were several information security incidents in the academic environment. In order to mitigate the problem, metrics identification is required to determine the risk of incidents. There are many risks model and metrics to estimate the risk, such as DREAD, OWASP, CVSS, etc. However, specific metrics are required to obtain appropriate risk values. Therefore, this study aims to define metrics for an academic institution. The proposed metrics are obtained from The Family Educational Rights and Privacy Act (FERPA) regulation. It consists of directory information, educational information, personally identifiable information, and risk of information leakage. In order to achieve the objective, this study involves survey and reliability analysis to result in output. The survey is conducted by involving 90 respondents with various levels of education and jobs. The Cronbach's alpha and Test-retest are methods to determine this study's reliability. According to reliability analysis, the Cronbach's alpha method results in coefficients for the metrics between 0.730 - 0.911, while the Test-retest method results in coefficients between 0.630 - 0.797. These coefficients have a reliable category, so the proposed metrics are adequate for determining risk of information security incidents in academic environments. The reliable metrics will be developed as variables of the risk assessment model for the academic environment in the future study.

Shalama Lekasa Nagari,1 Gudina Egata,2 Ame Mehadi,3 Tahir Ahmed Hassen,3 Temam Beshir Raru,3 Mohammed Abdurke,3 Mohammed Yuya,3 Shemsedin Abdulkadir,4 Hiwot Berhanu,3 Kedir Teji Roba3 1College of Health Sciences, Assosa University, Assosa, Ethiopia; 2College of Health and Medical Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4College of Health and Medical Sciences, Arsi University, Asella, Oromia, EthiopiaCorrespondence: Ame Mehadi, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia, Tel +251919118839, Fax +251256668081, Email mehadiame1554@gmail.comBackground: Anemia affects more than a quarter of non-pregnant women over the globe, with Sub-Saharan Africa bearing a disproportionate share. Although the use of family planning is beneficial in reducing anemia, lack of scientific study on anemia among family planning users of reproductive-age women is notable, particularly in the study setting. The purpose of this study was to determine the extent of anemia and associated factors in women who used family planning.Methods: A cross-sectional multi-centered study was conducted from March 3 to 29, 2019, among 443 non-pregnant reproductive age (15 to 49 years) women receiving family planning services in Ambo town. Sample size was calculated using Epi-info version 7 software. Participants were selected by systematic random sampling technique. Trained data collectors collected data using a structured pretested questionnaire, as well as venous blood and stool samples. Epi-Data and SPSS were used to enter and analyze data. The effect of independent variables on the outcome variable was determined by binary logistic regression analysis with adjusted odds ratio at 95% confidence interval and 5% margin of error. P-value < 0.05 was used to declare statistical significance.Results: This study revealed 28% (95% CI:23.9%, 32.3%) magnitude of anemia. Age of 25– 35 years [AOR:2.84, 95% CI:1.74, 4.64], implantable family planning method [AOR: 0.34, 95% CI: 0.12, 0.96], no previous use of family planning [AOR:2.62, 95% CI: 1.62, 4.24], household food insecurity [AOR: 2.04, 95% CI: 1.06, 3.93], parasite infestations [AOR:2.01, 95% CI: 1.12, 3.63], and regular intake of coffee/tea within 30 minutes post meal [AOR:3.85, 95% CI:1.24, 11.92] were independently associated with anemia.Conclusion: Anemia is a moderate public health concern among reproductive-age women receiving family planning services in the study area. There are missed opportunities to address the anemia burden during family planning services. This study emphasizes the importance of nutritional screening for early detection and targeted interventions for healthcare workers in reducing missed opportunities to prevent and control anemia in vulnerable populations.Keywords: anemia, family planning, reproductive age women, Ambo, Ethiopia

Depression and anxiety are the most common mental illnesses encountered in patients visiting psychiatry outpatient clinics. The relative safety of majority of antidepressants and anxiolytics has increased their routine use. However, limited data is available on the prescribing patterns of these drugs, especially from the state of Telangana. The aim of this study was to assess the prescription pattern in depression and anxiety disorders in patients attending Psychiatry outpatient department of a tertiary care teaching hospital in Telangana. A prospective observational study was conducted in Psychiatry outpatient department in Government General Hospital (GGH), Nalgonda over a period of 6 months (March 2021 to August 2021). A total of 45 patients suffering from anxiety and depression, based on International Classification of Diseases-10th edition (ICD-10), were selected. Data was collected using a semi-structured proforma and analyzed. A total of 103 drugs were prescribed and the average number of drugs per prescription was 2.29. It was found that majority of patients were in 15-35 years age group (60%), female (62.22%), married (60%) and from urban background (82.2%). In the study population, 55.55% were suffering from anxiety disorders, out of which 31.11% had Generalized anxiety disorder. Among the depressive disorders (44.45%) majority had Severe depressive episode (26.67%) followed by Moderate depressive episode (17.78%). The duration of illness was less than 6 months in majority of patients (75.56%). Selective serotonin reuptake inhibitors (SSRIs) were the most common group of drugs prescribed. 41 prescriptions (91.11%) contained SSRIs, and Sertraline was the most common drug followed by Escitalopram. 93.33% of the prescriptions also included Benzodiazepines (Clonazepam). 35.55% of the prescriptions had fixed dose combinations, commonest being Escitalopram 10mg + Clonazepam 0.5mg. [J Med Allied Sci 2023; 13(1):12-17]

Soil-transmitted helminths (STHs) persist as a significant global public health issue among neglected tropical diseases (NTDs), particularly in children. STH infection can induce immune responses that affect the course of the disease; if treatment fails, chronic infection can lead to stunting, especially among children aged 24–59 months, which is a vulnerable period for growth and development. We conducted a correlational, cross-sectional data collection study to evaluate the characteristics and association of 25(OH)D, interleukin-5 (IL-5), and interleukin-13 (IL-13) with the prevalence of STH infection in children aged 24–59 months in Bandung District, Indonesia, in October 2019–January 2023. We recruited 694 subjects (401 stunted and 293 normal-height children). The prevalence of STH infection among the stunted and normal-height groups was 5.7% (95% CI: 3.85–8.46%) and 3.4% (95% CI; 1.86–6.17%) (p = 0.156), respectively. The probability of the prevalence of STH infection in children with levels of 25(OH)D, IL-5, and IL-13 below the cut-off point was 6,93 to 16.71 times higher. We found a relationship between IL-5, IL-13, and environmental factors and the prevalence of STH infection in stunted children.

Background Cervical cancer ranks as the second most frequent cancer among all women in Ethiopia and the second most frequent cancer among women between 15 and 44 years of age, resulting in over 4884 moralities annually. Although there is a focus on health promotion through teaching and screening in Ethiopia’s intended transition toward universal healthcare, there is little information available on baseline levels of knowledge and screening uptake related to cervical cancer.Objectives This study explored the levels of knowledge and screening rates of cervical cancer along with its associated factors among women of reproductive age in Assosa Zone, Benishangul-Gumuz, Ethiopia in 2022.Methodology A facility-based cross-sectional study was conducted. A systematic sampling technique was used to select 213 reproductive-age women from selected health institutions, from 20 April 2022 to 20 July 2022. A validated and pretested questionnaire was used for data collection. Multi-logistic regression analyses were done to identify factors independently associated with cervical cancer screening. Adjusted OR with 95% CI was estimated to measure the strength of association. The level of statistical significance was declared at a p value of

Lingkungan yang nyaman sangat menentukan keberhasilan pada budidaya ayam broiler. Perubahan mikroklimat di sekitar lingkungan pemeliharaan dapat mempengaruhi perilaku unggas, jumlah ransum yang dikonsumsi, kebutuhan air minum, biomassa tubuh, dan produk yang dihasilkan. Unggas pedaging ini telah diketahui memiliki kualitas yang tinggi, waktu tumbuh yang cepat, dan produksi daging yang tinggi. Oleh karena itu hewan ternak ini mempunyai peluang yang tinggi untuk dipelihara dan dikembangkan oleh masyarakat. Riset dilakukan untuk menganalisis efek dinamika faktor lingkungan di lokasi peternakan terhadap perilaku unggas pedaging ini. Penelitian ini menggunakan metode eksplorasi dengan melakukan pengamatan perilaku broiler selama 15 hari, yaitu dengan cara mengamati 20 ekor ayam yang terdapat pada 4 kandang kecil dengan ulangan 3 kali dan diamati perilakunya pada jam 07.00, 13.30, dan 21.30. Pencatatan perilaku ayam dilakukan selama 30 menit, yang meliputi lokomosi, istirahat, minum, panting (terengah-engah), makan, mengepakkan sayap, dust bathing (mandi debu), dan feather pecking (mematuk bulu). Faktor lingkungan yang diukur meliputi temperatur ruang budidaya, kelembapan dan lama pencahayaan di Teaching Farm Close House Fakultas Peternakan dan Pertanian Universitas Diponegoro. Hasil pengolahan data menunjukkan bahwa faktor lingkungan berpengaruh terhadap perilaku ayam broiler, yang meliputi lokomosi, istirahat, minum, panting (terengah-engah), makan, mengepakkan sayap, dust bathing (mandi debu), dan feather pecking (mematuk bulu). Pengamatan perilaku sangat dianjurkan untuk mengetahui tingkat kenyamanan broiler di dalam kandang budidaya dalam upaya meningkatkan pertumbuhan dan produktivitas.

To bridge the gap between demand and supply of organs, deceased donors with extreme ages can be utilized. The object of this study was to compare elderly with non-elderly donors and to assess the predictors of organ utilization or wastage. This was a retrospective chart analysis. Univariate and multivariate logistic regression analysis of cohorts was carried out to predict organ utilization or wastage. Of the 716 deceased donors, 16.2% were elderly (≥60 years) and 83.8% were not elderly (≤59 years). Donors in the elderly cohort were more likely to be diabetic, hypertensive, overweight, and smokers compared with non-elderly donors. They had deranged terminal creatinine and succumbed to cerebrovascular accident or intracerebral hemorrhage. They had a high kidney donor risk index (KDRI) of 1.83 ± 0.46. Those in the younger donor cohort, were more likely to have succumbed to road traffic accident-associated traumatic brain injury, were subjected to more efforts to revive them in the intensive care unit via cardiopulmonary resuscitation, had deranged liver function tests, and had a KDRI of 0.93 ± 0.28. The kidney discard rate (KDR) and liver discard rate (LDR) in the elderly donors was 50% and 8.6%, respectively (vis-a-vis the non-elderly at 13.3 % and 7.5%). The KDR was significantly higher than the LDR in elderly donors. The main reason for this was the high number of “marginal kidneys”. We revealed that elderly donors formed a significant proportion of deceased donors. The utilization of the liver from deceased donors was more frequent compared with the kidney.

Background: On March 30, 2020, coronavirus disease 19 was declared pandemic and many countries of the world started working on the development of vaccine soon after China released the genetic structure of severe acute respiratory syndrome coronavirus 2. Drugs Controller General of India on January 3, 2021, accorded emergency use authorization to Oxford-AstraZeneca's ChAdOx1 nCoV-19 vaccine and vaccination drive commenced in India on January 16, 2021. The present study was conducted to determine the incidence adverse event following immunization (AEFI) among recipients of the first and second dose of the vaccine. Materials and Methods: A longitudinal descriptive study was conducted among 2529 vaccine beneficiaries who were asked about the side effects at 24 and 72 h after the first dose and second dose of vaccination with ChAdOx1 nCoV-19 vaccine. Passive surveillance was also done for 4 months. Results: AEFI was reported in 27.59%, 38.4%, and 19.96% of vaccines after both doses, first dose, and second dose, respectively. 14% did not report any AEFI with either dose of vaccine. Younger people had higher rates of AEFIs with both the doses. Pain at injection site and fever

Introduction: Right from the onset of the COVID-19 pandemic, health-care workers (HCWs) have been at the forefront in combating this deadly disease. The sudden emergence of COVID-19 and its continued persistence, has led to an unprecedented psychological stress among HCWs. To assess the level of stress and its effects on sleep quality of HCWs caring for COVID-19 patients, the present study was conducted among staff working in a dedicated COVID hospital. Methodology: The cross-sectional study was conducted among HCWs at a dedicated COVID hospital in northern India from September to October 20. To assess the levels of stress and quality of sleep, the participants were administered the Perceived Stress Scale and Pittsburgh Sleep Quality Index (PSQI). Results: One hundred and forty-two HCWs out of 162 responded completely. The mean age of the participants was 31.6 ± 6 years. Ninety-one (64.1%) were doctors and the rest 51 (35.1%) were paramedical staff. The mean PSQI global score was 6.9 ± 3.19. More than 50% of participants across all age categories reported moderate-to-high stress and poor sleep quality. Conclusion: This study shows that a high proportion of HCWs working in dedicated COVID hospitals suffer from stress and its varied deleterious effect, especially on sleep. Therefore, it is prudent for all stakeholders and decision-makers to take adequate steps for provision of psychological support for stress mitigation and implement measures for prevention and early identification of stress-related symptoms among HCWs working in COVID hospitals.

Background. In 2020, globally, 149.2 million under 5 years old children were stunted. In Africa, 61.4 million and 79 million under 5 years old children in Asia were also stunted in 2020. Stunting is a major public health problem in Ethiopia, where more than 5.5 million children under 5 years old are stunted. Stunting has irreversible and intergenerational health consequences, including impaired cognitive and physical growth, poor learning capacity, and reduced work productivity. Efforts to end stunting need comprehensive and context identification of risk factors. For this reason, this study aims to identify the predictors of stunting among children 6–35 months of age in Northwest Ethiopia. Method. A community-based, unmatched case–control study was employed in the Assosa zone, Benishangul Gumuz, west Ethiopia. A multistage and simple random sampling technique was used to select the study participants. Data were collected through interviewer-administered questionnaires using validated structured questionnaires and anthropometric measurements. Data were entered into Epidata version 3.1 and exported to SPSS 25.0 statistical software for analysis. Bivariate and multivariate analyses were computed. Finally, an adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to identify independent predictors of stunting using a multivariable logistic regression model. Result. The study included 544 mother–child pairs (181 cases and 363 controls), with a 100% response rate. The majority of the mothers, 85 (47.0%) in the case and 153 (42.1%) in the control group, were in the 25- to 29-year-old age group. This study revealed that mothers who had no formal education (AOR = 2.5, 95% CI (1.436, 4.180)), short maternal height (

Human urine is one of the primary wastes in urban areas, which has not been maximally processed and utilized until now. Human urine can be processed into biofertilizer with special processing procedures to minimize the negative impact of using urine as fertilizer and avoid odor, dirt, and contamination of pathogenic bacteria in the processing process. This prototype aims to design a Biotoilizer Automatic System with processing human urine into a biofertilizer and an automatic fertilization system. This system is equipped with a DC water pump, pH sensor, YL-69 sensor, ultrasonic sensor, real-time clock (RTC) NodeMCU microcontroller, and Arduino Uno. The method used in this research is an experimental method by designing technical designs and making prototypes of an Internet of Things (IoT) based automatic fertilization system that utilizes solar panels and is integrated with Bio toilets and designing software. The system's test results can process urine into a biofertilizer and fertilize automatically 95% based on regulated conditions and can be monitored with an application via a smartphone

This paper aims to provide an alternative design for Simple Cooperative Learning on online learning by accommodating a variety constraints and difficulties faced by teachers and students and answer weaknesses of existing methods. This study used research and development method using ADDIE (Analysis, Design, Development, Implementation, and Evaluation) design to produce an online-based cooperative learning model, namely SCL-D (Simple Cooperative Learning Design). The survey was conducted on a sample of 153 students at state and private vocational schools in Malang city. The results of this research are a learning model. Therefore, this method is suitable for completing research objectives, namely producing an SCL-D learning model that is suitable for learning accounting for vocational high schools with 3M requirements ‘easy, cheap, and attractive’. Online-based learning has many advantages as well as weaknesses. Various e-learning platforms make it easy for teachers and students to interact in online learning. The teacher's ability to design attractive distant learning is a determining factor for the success of the learning process. The test results of the SCL-D model show that through this simple cooperative learning design improves student learning achievement.

Soil-transmitted helminth (STH) among children aged 24-59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. an association study of case--control data was conducted in Bandung district from October 2019 to January 2023. sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed. statistical analysis was performed to evaluate the prevalence and association of 25(Oh) D, IL-4, IL-5, and IL-13 with the burden of sth infection in stunted children. in total, 401 stunted children were recruited. a higher burden of sth infection was found for lower levels of IL-5 (r = -0.477; p = 0.004) and IL-13 (r = -0.433; p = 0.028). Thus, 25(OH)D, IL-4, IL-5, and IL-13 play a role in the burden of sth infection. [ABSTRACT FROM AUTHOR]

Sebuah Corrigendum pada Efek Dinamika Faktor Lingkungan terhadap Perilaku Ayam Broiler di Kandang Close House oleh SUNARNO, Sunarno; NAGARI, A. P. Jurnal Peternakan Indonesia (Indonesian Journal of Animal Science), [S.l.], v. 24, n. 1, p. 8-20, feb. 2022. doi:https://doi.org/10.25077/jpi.24.1.8-20.2022. Urutan nama penulis diubah. Urutan yang salah adalah “SUNARNO, Sunarno; NAGARI, A. P”. Urutan yang benar adalah “NAGARI, A. P; SUNARNO, Sunarno”. Penulis mohon maaf atas kesalahan ini dan menyatakan bahwa ini tidak mengubah kesimpulan ilmiah artikel dengan cara apa pun. Artikel asli telah diperbarui. Catatan Penerbit Semua klaim yang diungkapkan dalam artikel ini adalah sepenuhnya milik penulis dan tidak selalu mewakili organisasi afiliasinya, atau milik penerbit, editor, dan mitra bestari. Setiap produk yang dapat dievaluasi dalam artikel ini, atau klaim yang mungkin dibuat oleh produsennya, tidak dijamin atau didukung oleh penerbit.

Indonesia is the second largest contributor to plastic waste after China. Despite the regulation, waste management in Indonesia has not met the standards of waste management that are environmentally sound. This forfeits the benefits of the waste management itself and brings negative impacts on public health and environment. This condition is aggravated by the costly access towards health facility. For this reason, socialization regarding waste management is needed. In addition, this program is equipped with an introduction towards waste bank and waste insurance as a practical solution. The existence of both options are expected to solve the problem of waste and health services for the community. The program aimed to help residents of RW 014 Kelurahan Tulusrejo, Malang City to comprehend the types of waste, separation of waste by category, impact on health, recycling and other details. The meetings were carried out twice from March to October 2020. The result of the agenda is that the residents continue to process waste using composter and are expected to form an independent waste bank management for local residents. Further, they are encouraged to learn more about waste insurance to manage the local waste in a more environment friendly manner.

Preserving ecosystem services, such as natural enemies that can provide pest control, can positively impact crops without compromising agricultural yield. Even though controlling pests by natural enemies has been suggested to reduce pests in agriculture, growers continue using conventional pesticides that kill beneficial predators. Here we studied whether the predation of avian and insect-beneficial predators varies in an apple orchard with conventional insecticide use compared to a bordering tree stand without insecticides. We studied the predation rates of mealworm pupae as a proxy to coddling moth pupae at 42 stations in both an apple orchard and a Eucalyptus stand at three distances (0 m, 50 m, and 100 m) from the border. Half of the stations were netted to prevent bird predation but were accessible to insects. The other half were non-netted and accessible to birds. We conducted six trials, each lasting two weeks, during which we recorded the predation of 504 stations with 5040 pupae. To validate which species predated the pupae, we added video cameras that took RGB videos during the day and IR videos at night in 45 stations and found that in net-free stations, birds preyed in 94.1% of stations in the orchard and 81.8% in the Eucalyptus stand. However, ants predated 70% of the pupae in stations with nets in the orchards and 100% in stations in the Eucalyptus strands. In addition, we found a significant rise in predation by birds as the distance into the orchard increased. Conversely, insect predation declined within the orchard but escalated in the adjacent unmanaged area. These findings suggest that the orchard’s environment negatively affects beneficial insect activity, specifically predatory ants. This study demonstrates that birds can play an essential role in predating insect pests inside the orchard. In addition, we believe that the decreased predation of ants within the orchard was due to intense insecticide use.

Introduction: Fasting denotes abstinence from food or drink or both for well-being, ritualistic, and spiritual purposes. This study was conducted to explore the effect of Navratras fasting on anthropometric parameters, biochemical factors, and pro-inflammatory biomarkers. Materials and Methods: This study was a short-term longitudinal follow-up study conducted during Navratras (Oct 2020) in a residential medical college campus in western Maharashtra. Assessment of the participants based on anthropometry, biochemical, and pro-inflammatory markers was done at three-time points 7 days before the start of intermittent fasting (T1) (before the start of Navratras), at the end of intermittent fasting (the last day of the festival) (T2) (during Navratras), and 1 week after completion of intermittent fasting (T3) (after the end of Navratras). Results: A total of 50 subjects participated in the study, and the mean age of study participants was 33.6 ± 10 years. There was a significant reduction in body weight (P = 0.001), waist circumference (P = 0.001), and hip circumference (P = 0.05) during the intermittent fasting period (T2). Significantly lower levels of total cholesterol (P < 0.01) and low density lipoprotein (LDL) (P < 0.01) were observed in the T2 and T3 time points of sampling. However, a significant increase in TNF-alpha, IL-1, IL-6, and IL-8 levels was observed during the T2 phase (P < 0.001). Conclusion: The current exploratory study evaluating the importance of intermittent fasting during Navratras showed a significant reduction in certain anthropometric as well as biochemical parameters. It is recommended that intermittent fasting may be considered by individuals who are overweight and need to improve overall health. However, it is important that like any other weight-loss program, intermittent fasting should also be undertaken under medical supervision. [ABSTRACT FROM AUTHOR]

Capacitated Vehicle Routing Problem (CVRP) is known as an NP-hard problem. It is because CVRP problems are very hard for finding optimal solutions, especially in large instances. In general, the NP-hard problem is difficult to solve in the exact method, so the metaheuristic approach is implemented in the CVRP problem to find a near-optimal solution in reasonable computational time. This research uses the DPSO algorithm for solving CVRP with ten instances of benchmark datasets. DPSO implementation uses tuning parameters with the One Factor at Time (OFAT) method to select the best DPSO parameters. The outcome objective function will be compared with several PSO models proposed in previous studies. Statistical test using One Way Reputed Measure ANOVA is needed to compare algorithm performance. First, ANOVA uses for comparing’s results. Then, ANOVA is also used to test DPSO’s performance compared with DPSO-SA, SR-1, and SR-2 algorithm. The computational result shows that the basic DPSO algorithm not competitive enough with other methods for solving CVRP.

Abstract Background The only means of achieving long-term survival in hepatocellular carcinoma (HCC) beyond transplant criteria is complete tumour resection. The limiting factor for curative resection in large HCC is an inadequate future liver remnant (FLR) that might culminate into post hepatectomy liver failure (PHLF). The most common method that has been employed thus far to increase the FLR is portal vein embolization (PVE), which has its own set of drawbacks mainly inadequate hypertrophy, longer duration to achieve adequate FLR and tumour progression in the waiting period. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel upcoming technique that aids in achieving rapid hypertrophy of FLR, thereby facilitating resection of an otherwise unresectable tumour. Case presentation The authors present a case of a 46-year-old female with non-metastatic large HCC with inadequate FLR unsuitable for upfront hepatectomy. A two-stage surgical resection with ALPPS technique was preferred over PVE in this patient. This facilitated early hypertrophy of FLR and complete surgical resection of the tumour was performed successfully with an uneventful perioperative period. The patient was disease free at 16 months of follow-up. Conclusion ALPPS is a feasible option for otherwise unresectable large HCCs in carefully selected patients with acceptable morbidity.

Cluster analysis aims to classify data objects into two categories: objects that are similar in characteristics in one cluster and objects that are different in characteristics with the other objects of another cluster. K-Means is a method included in the distance-based clustering algorithm that starts by determining the number of desired clusters. Malnutrition is one of the biggest concerns in Indonesia. According to Riskesdas 2018 data, as many as 17.7% infants under 60-month-old are still having problems with nutrition intake while 3.9% are having malnutrition. This might result in higher death rate. This research was conducted to classify the nutritional status of infants under 60-month-old conducted by the C-Means Clustering method. This research is non-reactive, using secondary data in Ponkesdes Mayangrejo, Bojonegoro without direct interaction with the subject. This study concluded that the grouping of nutritional status is possible by using K-Means with 4 clusters formed which are 23 malnourished toddlers, 17 undernourished toddlers, 7 nourished toddlers, and 10 over-nourished toddlers.

Background Hypertension is a major risk factor for cardiovascular (CVD) disease related deaths worldwide. It affects more than 20% of adults in Ethiopia, making it a major public health concern. Although it is important to uncover the hidden extent of hypertension, there is limited information on the proportion of undiagnosed hypertension in rural areas of the country. Objective This study aimed to determine the magnitude of undiagnosed hypertension and associated factors among adults living in the rural Dano district, Central Ethiopia 2020. Methods and materials A quantitative, community-based cross-sectional study conducted from May to July 2020. A three-stage sampling technique was used to select a total of 605 study participants. A Validated tool was used to assess the participant’s behavioral characteristics. Blood pressure was measured using digital blood pressure apparatus. The mean of three blood measurements was used to classify hypertension after intra-class correlation was tested. Standardized instruments were used to assess participants’ health-seeking behavior and knowledge of the hypertensive disease. The proportion of undiagnosed hypertension was determined among patients with hypertension. The regression analyses were done to determine factors associated with undiagnosed hypertension. The adjusted odds ratio with 95% CI was estimated to measure the strength of the association. The level of statistical significance was set at a p-value < 0.05. Results The prevalence of undiagnosed hypertension was 21.32% (CI: 19.95%, 25.8%). Living in a household with the low wealth index [(AOR: 3.5,95%CI: (1.6,6.4)], far distance to health facility, [(AOR: 0.155,95%CI: (0.11.0.67)], underweight, [AOR = 2.2.1,95%CI:(2.00,4.22)], use of smokeless tobacco products, [AOR = 3.2,95%Cl:(1.88,4.75)], and participants’ knowledge of hypertension were independently associated with undiagnosed hypertension. Conclusion This study shows that undiagnosed hypertension is a major public health problem in the study area. Living in a household with a low wealth index, being far from a health facility, being underweight, using smokeless tobacco products, and having little knowledge about hypertension increase the likelihood of having undiagnosed Hypertension. Hypertension health information, particularly to smokes tobacco users, could improve the perceived susceptibility to hypertensive disease, and reduce the hidden extent of hypertension.

The differentiation of embryonic stem cells into various lineages is highly dependent on the chromatin state of the genome and patterns of gene expression. To identify lineage-specific enhancers driving the differentiation of progenitors into pancreatic cells, we used a previously described computational framework called Total Functional Score of Enhancer Elements (TFSEE), which integrates multiple genomic assays that probe both transcriptional and epigenomic states. First, we evaluated and compared TFSEE as an enhancer-calling algorithm with enhancers called using GRO-seq-defined enhancer transcripts (method 1) versus enhancers called using histone modification ChIP-seq data (method 2). Second, we used TFSEE to define the enhancer landscape and identify transcription factors (TFs) that maintain the multipotency of a subpopulation of endodermal stem cells during differentiation into pancreatic lineages. Collectively, our results demonstrate that TFSEE is a robust enhancer-calling algorithm that can be used to perform multilayer genomic data integration to uncover cell type-specific TFs that control lineage-specific enhancers.

Abstract Background Epigenetic regulators are frequently mutated or aberrantly expressed in a variety of cancers, leading to altered transcription states that result in changes in cell identity, behavior, and response to therapy. Results To define alterations in epigenetic landscapes in breast cancers, we profiled the distributions of 8 key histone modifications by ChIP-Seq, as well as primary (GRO-seq) and steady state (RNA-Seq) transcriptomes, across 13 distinct cell lines that represent 5 molecular subtypes of breast cancer and immortalized human mammary epithelial cells. Discussion Using combinatorial patterns of distinct histone modification signals, we defined subtype-specific chromatin signatures to nominate potential biomarkers. This approach identified AFAP1-AS1 as a triple negative breast cancer-specific gene associated with cell proliferation and epithelial-mesenchymal-transition. In addition, our chromatin mapping data in basal TNBC cell lines are consistent with gene expression patterns in TCGA that indicate decreased activity of the androgen receptor pathway but increased activity of the vitamin D biosynthesis pathway. Conclusions Together, these datasets provide a comprehensive resource for histone modification profiles that define epigenetic landscapes and reveal key chromatin signatures in breast cancer cell line subtypes with potential to identify novel and actionable targets for treatment.