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The purpose of the article is to evaluate the effectiveness of managing the educational markets in the countries of the world that have the highest global competitiveness in the sphere of education, to determine and compare the factors of development of universities in the conditions of Industry 4.0 in these countries, and to develop recommendations for increasing the effectiveness of managing the educational market. For evaluating the effectiveness of managing the educational market, the authors' method is used, which is based on the classical formula of measuring effectiveness as a ratio of results and costs. For evaluating the susceptibility of the indicators of development of universities in the conditions of Industry 4.0 to the influence of various factors, the authors use the method of correlation analysis and the method of calculation of direct average. The information and analytical basis of the research includes the analytical and rating materials of CWUR, Legatum Institute, Online learning consortium, QS, Times Higher Education (THE) and World Bank for 2019. It is substantiated that quality is the basis of effective management of the educational market and is a goal of development of universities in the conditions of Industry 4.0. Growth of the volume of state financing of education and improvement of the macro-economic environment will allow achieveing internationalization of education, but they have small influence on its results. Quality of education determines the effectiveness of the national market of education, but is hardly managed at the level of macro-economy.

В статье рассмотрены этапы возникновения здравоохранения на Урале во время Гражданской войны, показан вклад советских ученых-медиков в борьбе с эпидемиями во время Гражданской войны, дана оценка развитию здравоохранения в послевоенный период. The article examines the stages of the emergence of healthcare in the Urals during the Civil War, shows the contribution of Soviet medical scientists in the fight against epidemics during the Civil War, assesses the development of healthcare in the post-war period.

The article raises the problem of improving the quality of vocational education which largely depends on the joint efforts of all stakeholders of the labor market of territorial education. Therefore, the creation and successful functioning of social partnership will allow in the long term to prepare qualified and in-demand specialists for regional enterprises. According to the authors, the process of formation and development of social partnership in the field of vocational education takes place on the background of reconsidering the role of the State in organizing and governing vocational education under conditions of rapid labor market development.

В данной статье поднимается вопрос повышения качества профессионального образования, которое во многом зависит от совместных усилий всех заинтересованных сторон рынка труда территориального образования. Именно поэтому создание и успешное функционирование социального партнерства позволит в перспективе подготовить квалифицированных и востребованных специалистов для региональных предприятий. Как отмечают авторы, процесс формирования и развития социального партнерства в сфере профессионального образования проходит на фоне переосмысления роли государства в организации и управлении профессиональным образованием в условиях ускоренного развития рынка труда., The article raises the problem of improving the quality of vocational education which largely depends on the joint efforts of all stakeholders of the labor market of territorial education. Therefore, the creation and successful functioning of social partnership will allow in the long term to prepare qualified and in-demand specialists for regional enterprises. According to the authors, the process of formation and development of social partnership in the field of vocational education takes place on the background of reconsidering the role of the State in organizing and governing vocational education under conditions of rapid labor market development., Статьяра професси пĕлĕвĕн пахалăхне ӳстерес ыйтăва хускатнă. Ку нумай чухне ĕç рынокне хутшăнакансем пĕрле вăй хунинчен килет. Çавăнпах социаллă ĕçтешлĕх йĕркелесе тухăçлă ĕçлесе пыни малашне регионти предприятисем валли квалификациллĕ специалистсем хатĕрлеме пулăшать. Авторсем палăртнă тăрăх, професси пĕлĕвĕ хутлăхĕнчи социаллă ĕçтешлĕхĕн йĕркеленӳ тата аталану процесĕ ĕç рынокĕ питĕ хăвăрт аталанса пынă условисенче професси пĕлĕвĕнчи патшалăх пĕлтерĕшĕ пирки çĕнĕлле шухăшланă тапхăрта иртет.

The study justifies the methodological approach to managing the ecological-and-economic development of the region, based on the principle of strategical safe ecological-and-economic development. The analysis of the effectiveness of the strategic decision-making system for the social-and-economic development of the region was carried out. The principal scheme of the decision-making mechanism for the environmental-and-economic development management was developed, including the strategic environmental assessment, which takes into account the ecological and economic state of the region. The proposed methodological approach to the assessment of the ecological-and-economic situation in the region will allow to reveal some influencing factors, to form the system of assessment indicators, which can be used to control the ecological-and-economic situation and to develop strategical management decisions for the economic development of the region. The scheme of interaction of the strategical managerial decision-making systems as well as the system of regulation of the investment climate in the region can become the basis for the selection of the type of investment policy, corresponding to the ecological-and-economic development of the region. The conceptual framework of decision-making for the ecological-and-economic development of the region as a management tool will make it possible to choose the environmentally acceptable option for the development and functioning of the balanced environmental-and-economic sector.

The article describes some general methods of diagnostics of the sensors of microprocessor control systems controlling a hybrid transmission of a vehicle. The task to research the processes of sensors diagnosing is stated.

In the present study, we characterized the gene product of open reading frame 3 encoded at human chromosome 20 (C20orf3), which represents a member of the lactonohydrolase super family. Multiple-tissue Northern blot analysis showed ubiquitous expression of the 2.4 kb transcript coding for 416 amino acids, with highest levels in human liver, placenta and kidney. After recombinant production of protein variants in Escherichia coli and insect cells, antibodies directed against different epitopes within the C20orf3 gene product were generated. Using these immunoreagents, protein expression was demonstrated in the liver, and glomerular and tubular structures of the kidney, as well as in endothelial cells and arterial wall. Positive staining was also observed at the pancreatic islets of Langerhans. Using immunoblotting, we identified three size variants. In line with the results of in silico analysis demonstrating a single transmembrane sequence (amino acids 40–61) at the N-terminus of the full-length protein, FACS cell-surface staining confirmed a mainly extracellular localization of the full-length protein. Sucrose density gradient cell fractionation revealed membrane association of the dominant 50 kDa variant in HepG2 and Rin-5F cells. The finding of a strong arylesterase activity with β-naphthyl acetate and phenyl acetate of the C20orf3 protein-containing fractions suggests potential involvement of this protein in enzymatic processes. C20orf3 promoter-driven reporter assays, which were verified by gene-specific RT-qPCR (real-time quantitative PCR) showed a strong inhibitory effect of human serum on transcription using the HEK-293 human embryonic kidney cell line. In conclusion, we characterized the structure and expression pattern of the C20orf3 gene product. According to a series of analogies with PON (paraoxonase) family members, we speculate that the C20orf3 gene product represents a new member of this important protein family present at the cellular level.

Secretagogin is a recently cloned human β-cell-expressed EF-hand Ca2+-binding protein. Converging evidence indicates that it exerts Ca2+sensor activity and is involved in regulation of insulin synthesis and secretion. To obtain a potent tool for the extension of its functional analysis in rat in vitro systems, we cloned the rat homolog of human secretagogin. Using comparative sequence analysis, immunostaining, and immunoblotting, we demonstrated a high degree of sequence homology and similar tissue expression patterns of human and rat secretagogin. Highest rat secretagogin expression levels were found in pancreatic β-cells. On the basis of newly generated anti-rat secretagogin antibodies, we established a rat secretagogin-specific sandwich capture ELISA and demonstrated release of secretagogin from viable Rin-5F cells. Dexamethasone treatment of Rin-5F cells resulted in an increased secretagogin release rate, which was inversely correlated with insulin secretion. In contrast, the secretagogin transcription rate was markedly reduced. This resulted in a decreased intracellular secretagogin content under the influence of dexamethasone. Sucrose gradient cell fractionation analysis of Rin-5F cells confirmed the predominant cytosolic localization of secretagogin, with only limited association of secretagogin with insulin granules. The loss of intracellular secretagogin after dexamethasone treatment affected predominantly the insulin granule-associated secretagogin fractions. The sequence homology and the comparable tissue expression patterns of human and rat secretagogin indicate conserved intracellular functions. The effects of dexamethasone on the total secretagogin content in Rin-5F cells and on its intracellular distribution might result in an impaired Ca2+sensitivity of dexamethasone-treated insulin-secreting cells.

This paper assesses trends in the development of agricultural enterprises in the XXI century and marks the reasons for the low efficiency of partnerships. The features of integration stages of agricultural producers and processing enterprises are reviewed. Signs which may classify the integration are proposed. A conclusion about the need for a new conception of the organizational structure of the cultivated mushrooms market is made. The basic idea behind the concept could be the creation in the cultivated mushrooms market of a variety of organizational integrated structures, which would maintain competitive environment. The development of integration processes in the direction of economic recovery in agriculture will reduce the investment risks in the mushroom growing, the functions of cultivated mushrooms market will be accumulated in a single integrated structure. In conclusion, a number of conceptual provisions that must be considered in the strategy of diversification for mushroom growing companies of intersectoral agroeconomic integration are highlighted.