1. Regulation of adipose tissue inflammation by interleukin 6.
- Author
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Han MS, White A, Perry RJ, Camporez JP, Hidalgo J, Shulman GI, and Davis RJ
- Subjects
- ADAM10 Protein genetics, ADAM10 Protein immunology, ADAM17 Protein genetics, ADAM17 Protein immunology, Adipocytes immunology, Animals, Female, Humans, Interleukin-6 genetics, Macrophages immunology, Male, Mice, Mice, Inbred C57BL, Muscle Cells immunology, Myeloid Cells immunology, Obesity genetics, Species Specificity, Adipose Tissue immunology, Interleukin-6 immunology, Obesity immunology
- Abstract
Obesity is associated with a chronic state of low-grade inflammation and progressive tissue infiltration by immune cells and increased expression of inflammatory cytokines. It is established that interleukin 6 (IL6) regulates multiple aspects of metabolism, including glucose disposal, lipolysis, oxidative metabolism, and energy expenditure. IL6 is secreted by many tissues, but the role of individual cell types is unclear. We tested the role of specific cells using a mouse model with conditional expression of the Il6 gene. We found that IL6 derived from adipocytes increased, while IL6 derived from myeloid cells and muscle suppressed, macrophage infiltration of adipose tissue. These opposite actions were associated with a switch of IL6 signaling from a canonical mode (myeloid cells) to a noncanonical trans -signaling mode (adipocytes and muscle) with increased expression of the ADAM10/17 metalloprotease that promotes trans -signaling by the soluble IL6 receptor α. Collectively, these data demonstrate that the source of IL6 production plays a major role in the physiological regulation of metabolism., Competing Interests: The authors declare no competing interest., (Copyright © 2020 the Author(s). Published by PNAS.)
- Published
- 2020
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