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220 results on '"Muscat, J."'

1. Knowledge and perceptions of tobacco-related media in rural Appalachia

Author: Branstetter, S A, Lengerich, E, Dignan, M, and Muscat, J
Published: 2015

2. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author: Goyal, N, Hennessy, M, Lehman, E, Lin, W, Agudo, A, Ahrens, W, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Conway, D, Curado, M, Dal Maso, L, Daudt, A, Edefonti, V, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kanda, J, Kelsey, K, Hansen, B, Koifman, R, Lagiou, P, La Vecchia, C, Levi, F, Li, G, Lissowska, J, Mendoza Lopez, R, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moysich, K, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Boffetta, P, Hashibe, M, Lee, Y, Muscat, J, Goyal N., Hennessy M., Lehman E., Lin W., Agudo A., Ahrens W., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Conway D., Curado M., Dal Maso L., Daudt A. W., Edefonti V., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Hayes R. B., Healy C., Herrero R., Holcatova I., Kanda J. L., Kelsey K., Hansen B., Koifman R., Lagiou P., La Vecchia C., Levi F., Li G., Lissowska J., Mendoza Lopez R., Luce D., Macfarlane G., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moysich K., Negri E., Olshan A. F., Pandics T., Polesel J., Purdue M., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S. M., Serraino D., Shangina O., Smith E., Sturgis E. M., Swiatkowska B., Thomson P., Vaughan T. L., Vilensky M., Winn D. M., Wunsch-Filho V., Yu G. -P., Zevallos J. P., Zhang Z. -F., Zheng T., Znaor A., Boffetta P., Hashibe M., Lee Y. -C. A., Muscat J. E., Goyal, N, Hennessy, M, Lehman, E, Lin, W, Agudo, A, Ahrens, W, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Conway, D, Curado, M, Dal Maso, L, Daudt, A, Edefonti, V, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kanda, J, Kelsey, K, Hansen, B, Koifman, R, Lagiou, P, La Vecchia, C, Levi, F, Li, G, Lissowska, J, Mendoza Lopez, R, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moysich, K, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Boffetta, P, Hashibe, M, Lee, Y, Muscat, J, Goyal N., Hennessy M., Lehman E., Lin W., Agudo A., Ahrens W., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Conway D., Curado M., Dal Maso L., Daudt A. W., Edefonti V., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Hayes R. B., Healy C., Herrero R., Holcatova I., Kanda J. L., Kelsey K., Hansen B., Koifman R., Lagiou P., La Vecchia C., Levi F., Li G., Lissowska J., Mendoza Lopez R., Luce D., Macfarlane G., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moysich K., Negri E., Olshan A. F., Pandics T., Polesel J., Purdue M., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S. M., Serraino D., Shangina O., Smith E., Sturgis E. M., Swiatkowska B., Thomson P., Vaughan T. L., Vilensky M., Winn D. M., Wunsch-Filho V., Yu G. -P., Zevallos J. P., Zhang Z. -F., Zheng T., Znaor A., Boffetta P., Hashibe M., Lee Y. -C. A., and Muscat J. E.
Abstract: Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and Methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer.
Published: 2023

3. Cotunnite-structured titanium dioxide: the hardest known oxide

Author: Dubrovinsky, L. S., Dubrovinskaia, N. A., Swamy, V., Muscat, J., Harrison, N. M., Ahuja, R., and Holm, B.
Subjects: Condensed Matter - Materials Science, Condensed Matter - Other Condensed Matter
Abstract: Despite great technological importance and many investigations, a material with measured hardness comparable to that of diamond or cubic boron nitride has yet to be identified. Combined theoretical and experimental investigations led to the discovery of a new polymorph of titanium dioxide with titanium nine-coordinated to oxygen in the cotunnite (PbCl2) structure. Hardness measurements on the cotunnite-structured TiO2 synthesized at pressures above 60 GPa and temperatures above 1000 K reveal that this material is the hardest oxide yet discovered. Furthermore, it is one of the least compressible (with a measured bulk modulus of 431 GPa) and hardest (with a microhardness of 38 GPa) polycrystalline materials studied thus far., Comment: This is full version of the paper published as Brief Communications in Nature, 410, 653-654
Published: 2009

4. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author: Goyal, N., Hennessy, M., Lehman, E., Lin, W., Agudo, A., Ahrens, W., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Conway, D., Curado, M., Dal Maso, L., Daudt, A. W., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kanda, J. L., Kelsey, K., Hansen, B., Koifman, R., Lagiou, Pagona, La Vecchia, C., Levi, F., Li, G., Lissowska, J., Mendoza Lopez, R., Luce, D., Macfarlane, G., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moysich, K., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Muscat, J. E., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., Boffetta P., Goyal, N., Hennessy, M., Lehman, E., Lin, W., Agudo, A., Ahrens, W., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Conway, D., Curado, M., Dal Maso, L., Daudt, A. W., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kanda, J. L., Kelsey, K., Hansen, B., Koifman, R., Lagiou, Pagona, La Vecchia, C., Levi, F., Li, G., Lissowska, J., Mendoza Lopez, R., Luce, D., Macfarlane, G., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moysich, K., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Muscat, J. E., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., and Boffetta P.
Abstract: Objective We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and Methods The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer.
Published: 2023

5. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

Author: Bosetti, C., Rosato, V., Li, D., Silverman, D., Petersen, G.M., Bracci, P.M., Neale, R.E., Muscat, J., Anderson, K., Gallinger, S., Olson, S.H., Miller, A.B., Bas Bueno-de-Mesquita, H., Scelo, G., Janout, V., Holcatova, I., Lagiou, P., Serraino, D., Lucenteforte, E., Fabianova, E., Baghurst, P.A., Zatonski, W., Foretova, L., Fontham, E., Bamlet, W.R., Holly, E.A., Negri, E., Hassan, M., Prizment, A., Cotterchio, M., Cleary, S., Kurtz, R.C., Maisonneuve, P., Trichopoulos, D., Polesel, J., Duell, E.J., Boffetta, P., La Vecchia, C., and Ghadirian, P.
Published: 2014
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6. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author: Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y. -C. A., Hashibe M., Boffetta P., Conway D. I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S. -C., Curado M. P., Dal Maso L., Daudt A. W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N. D., Hayes R. B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G. J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R. A., Moysich K., Muscat J., Negri E., Olshan A. F., Pandics T., Polesel J., Purdue M. P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S. M., Serraino D., Shangina O., Smith E., Sturgis E. M., Swiatkowska B., Thomson P., Toporcov T. N., Vaughan T. L., Vilensky M., Winn D. M., Wunsch-Filho V., Yu G. -P., Zevallos J. P., Zhang Z. -F., Zheng T., Znaor A., Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y. -C. A., Hashibe M., Boffetta P., Conway D. I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S. -C., Curado M. P., Dal Maso L., Daudt A. W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N. D., Hayes R. B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G. J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R. A., Moysich K., Muscat J., Negri E., Olshan A. F., Pandics T., Polesel J., Purdue M. P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S. M., Serraino D., Shangina O., Smith E., Sturgis E. M., Swiatkowska B., Thomson P., Toporcov T. N., Vaughan T. L., Vilensky M., Winn D. M., Wunsch-Filho V., Yu G. -P., Zevallos J. P., Zhang Z. -F., Zheng T., and Znaor A.
Abstract: Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
Published: 2021

7. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Author: Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoi, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, G, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, T, Moyses, R, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Olshan, A, Zevallos, J, Sturgis, E, Li, G, Levi, F, Zhang, Z, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, S, Zheng, T, Vaughan, T, Kelsey, K, Mcclean, M, Benhamou, S, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Chuang, S, Boffetta, P, Hashibe, M, Yuan-Chin, A, Edefonti, V, Di Credico G., Polesel J., Dal Maso L., Pauli F., Torelli N., Luce D., Radoi L., Matsuo K., Serraino D., Brennan P., Holcatova I., Ahrens W., Lagiou P., Canova C., Richiardi L., Healy C. M., Kjaerheim K., Conway D. I., Macfarlane G. J., Thomson P., Agudo A., Znaor A., Franceschi S., Herrero R., Toporcov T. N., Moyses R. A., Muscat J., Negri E., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Olshan A. F., Zevallos J. P., Sturgis E. M., Li G., Levi F., Zhang Z. -F., Morgenstern H., Smith E., Lazarus P., La Vecchia C., Garavello W., Chen C., Schwartz S. M., Zheng T., Vaughan T. L., Kelsey K., McClean M., Benhamou S., Hayes R. B., Purdue M. P., Gillison M., Schantz S., Yu G. -P., Chuang S. -C., Boffetta P., Hashibe M., Yuan-Chin A. L., Edefonti V., Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoi, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, G, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, T, Moyses, R, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Olshan, A, Zevallos, J, Sturgis, E, Li, G, Levi, F, Zhang, Z, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, S, Zheng, T, Vaughan, T, Kelsey, K, Mcclean, M, Benhamou, S, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Chuang, S, Boffetta, P, Hashibe, M, Yuan-Chin, A, Edefonti, V, Di Credico G., Polesel J., Dal Maso L., Pauli F., Torelli N., Luce D., Radoi L., Matsuo K., Serraino D., Brennan P., Holcatova I., Ahrens W., Lagiou P., Canova C., Richiardi L., Healy C. M., Kjaerheim K., Conway D. I., Macfarlane G. J., Thomson P., Agudo A., Znaor A., Franceschi S., Herrero R., Toporcov T. N., Moyses R. A., Muscat J., Negri E., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Olshan A. F., Zevallos J. P., Sturgis E. M., Li G., Levi F., Zhang Z. -F., Morgenstern H., Smith E., Lazarus P., La Vecchia C., Garavello W., Chen C., Schwartz S. M., Zheng T., Vaughan T. L., Kelsey K., McClean M., Benhamou S., Hayes R. B., Purdue M. P., Gillison M., Schantz S., Yu G. -P., Chuang S. -C., Boffetta P., Hashibe M., Yuan-Chin A. L., and Edefonti V.
Abstract: Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Published: 2020

8. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author: Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D. I., Macfarlane T. V., Thomson P., Agudo A., Znaor A., Boaventura Rios L. F., Toporcov T. N., Franceschi S., Herrero R., Muscat J., Olshan A. F., Zevallos J. P., La Vecchia C., Winn D. M., Sturgis E. M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z. -F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S. M., Vaughan T. L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R. B., Purdue M., Gillison M., Schantz S., Yu G. -P., Brenner H., D'Souza G., Gross N. D., Chuang S. -C., Boffetta P., Hashibe M., Lee Y. -C. A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M. P., Menezes A., Daudt A. W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D. I., Macfarlane T. V., Thomson P., Agudo A., Znaor A., Boaventura Rios L. F., Toporcov T. N., Franceschi S., Herrero R., Muscat J., Olshan A. F., Zevallos J. P., La Vecchia C., Winn D. M., Sturgis E. M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z. -F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S. M., Vaughan T. L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R. B., Purdue M., Gillison M., Schantz S., Yu G. -P., Brenner H., D'Souza G., Gross N. D., Chuang S. -C., Boffetta P., Hashibe M., Lee Y. -C. A., and Dal Maso L.
Abstract: Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies
Published: 2019

9. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Author: Chang, C, Chang, S, Chuang, S, Berthiller, J, Ferro, G, Matsuo, K, Wunsch-Filho, V, Toporcov, T, de Carvalho, M, La Vecchia, C, Olshan, A, Zevallos, J, Serraino, D, Muscat, J, Sturgis, E, Li, G, Morgenstern, H, Levi, F, Dal Maso, L, Smith, E, Kelsey, K, Mcclean, M, Vaughan, T, Lazarus, P, Ramroth, H, Chen, C, Schwartz, S, Winn, D, Bosetti, C, Edefonti, V, Garavello, W, Negri, E, Hayes, R, Purdue, M, Boccia, S, Cadoni, G, Shangina, O, Koifman, R, Curado, M, Vilensky, M, Swiatkowska, B, Herrero, R, Franceschi, S, Benhamou, S, Fernandez, L, Menezes, A, Daudt, A, Mates, D, Schantz, S, Yu, G, Lissowska, J, Brenner, H, Fabianova, E, Rudnai, P, Brennan, P, Boffetta, P, Zhang, Z, Hashibe, M, Lee, Y, Chang C. -P., Chang S. -C., Chuang S. -C., Berthiller J., Ferro G., Matsuo K., Wunsch-Filho V., Toporcov T. N., de Carvalho M. B., La Vecchia C., Olshan A. F., Zevallos J. P., Serraino D., Muscat J., Sturgis E. M., Li G., Morgenstern H., Levi F., Dal Maso L., Smith E., Kelsey K., McClean M., Vaughan T. L., Lazarus P., Ramroth H., Chen C., Schwartz S. M., Winn D. M., Bosetti C., Edefonti V., Garavello W., Negri E., Hayes R. B., Purdue M. P., Boccia S., Cadoni G., Shangina O., Koifman R., Curado M. P., Vilensky M., Swiatkowska B., Herrero R., Franceschi S., Benhamou S., Fernandez L., Menezes A. M. B., Daudt A. W., Mates D., Schantz S., Yu G. -P., Lissowska J., Brenner H., Fabianova E., Rudnai P., Brennan P., Boffetta P., Zhang Z. -F., Hashibe M., Lee Y. -C. A., Chang, C, Chang, S, Chuang, S, Berthiller, J, Ferro, G, Matsuo, K, Wunsch-Filho, V, Toporcov, T, de Carvalho, M, La Vecchia, C, Olshan, A, Zevallos, J, Serraino, D, Muscat, J, Sturgis, E, Li, G, Morgenstern, H, Levi, F, Dal Maso, L, Smith, E, Kelsey, K, Mcclean, M, Vaughan, T, Lazarus, P, Ramroth, H, Chen, C, Schwartz, S, Winn, D, Bosetti, C, Edefonti, V, Garavello, W, Negri, E, Hayes, R, Purdue, M, Boccia, S, Cadoni, G, Shangina, O, Koifman, R, Curado, M, Vilensky, M, Swiatkowska, B, Herrero, R, Franceschi, S, Benhamou, S, Fernandez, L, Menezes, A, Daudt, A, Mates, D, Schantz, S, Yu, G, Lissowska, J, Brenner, H, Fabianova, E, Rudnai, P, Brennan, P, Boffetta, P, Zhang, Z, Hashibe, M, Lee, Y, Chang C. -P., Chang S. -C., Chuang S. -C., Berthiller J., Ferro G., Matsuo K., Wunsch-Filho V., Toporcov T. N., de Carvalho M. B., La Vecchia C., Olshan A. F., Zevallos J. P., Serraino D., Muscat J., Sturgis E. M., Li G., Morgenstern H., Levi F., Dal Maso L., Smith E., Kelsey K., McClean M., Vaughan T. L., Lazarus P., Ramroth H., Chen C., Schwartz S. M., Winn D. M., Bosetti C., Edefonti V., Garavello W., Negri E., Hayes R. B., Purdue M. P., Boccia S., Cadoni G., Shangina O., Koifman R., Curado M. P., Vilensky M., Swiatkowska B., Herrero R., Franceschi S., Benhamou S., Fernandez L., Menezes A. M. B., Daudt A. W., Mates D., Schantz S., Yu G. -P., Lissowska J., Brenner H., Fabianova E., Rudnai P., Brennan P., Boffetta P., Zhang Z. -F., Hashibe M., and Lee Y. -C. A.
Abstract: Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.
Published: 2019

10. Mentholated Cigarettes and Smoking Habits in Whites and Blacks

Author: Muscat, J. E., Richie, J. P., and Stellman, S. D.
Published: 2002

11. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author: Bravi, F., Lee, Y. -C. A., Hashibe, M., Boffetta, Paolo, Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Chuang, S. -C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, Pagona, Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., Negri E., Bravi, F., Lee, Y. -C. A., Hashibe, M., Boffetta, Paolo, Conway, D. I., Ferraroni, M., La Vecchia, C., Edefonti, V., Agudo, A., Ahrens, W., Benhamou, S., Boccia, Stefania, Brennan, P., Brenner, H., Cadoni, Gabriella, Canova, C., Chen, Chen, Chuang, S. -C., Curado, M. P., Dal Maso, L., Daudt, A. W., D'Souza, G., Fabianova, E., Fernandez, L., Franceschi, S., Garavello, W., Gillison, M., Gross, N. D., Hayes, R. B., Healy, C., Herrero, R., Holcatova, I., Kelsey, K., Kjaerheim, K., Koifman, R., Lagiou, Pagona, Lazarus, P., Levi, F., Li, G., Lissowska, J., Luce, D., Macfarlane, G. J., Mates, D., Matsuo, K., Mcclean, M., Menezes, A., Menvielle, G., Morgenstern, H., Moyses, R. A., Moysich, K., Muscat, J., Negri, Erica, Olshan, A. F., Pandics, T., Polesel, J., Purdue, M. P., Radoi, L., Ramroth, H., Richiardi, L., Schantz, S., Schwartz, S. M., Serraino, D., Shangina, O., Smith, E., Sturgis, E. M., Swiatkowska, B., Thomson, P., Toporcov, T. N., Vaughan, T. L., Vilensky, M., Winn, D. M., Wunsch-Filho, V., Yu, G. -P., Zevallos, J. P., Zhang, Z. -F., Zheng, T., Znaor, A., Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Lagiou P., and Negri E.
Abstract: Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
Published: 2021

12. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Author: Di Credico, G. Polesel, J. Dal Maso, L. Pauli, F. Torelli, N. Luce, D. Radoï, L. Matsuo, K. Serraino, D. Brennan, P. Holcatova, I. Ahrens, W. Lagiou, P. Canova, C. Richiardi, L. Healy, C.M. Kjaerheim, K. Conway, D.I. Macfarlane, G.J. Thomson, P. Agudo, A. Znaor, A. Franceschi, S. Herrero, R. Toporcov, T.N. Moyses, R.A. Muscat, J. Negri, E. Vilensky, M. Fernandez, L. Curado, M.P. Menezes, A. Daudt, A.W. Koifman, R. Wunsch-Filho, V. Olshan, A.F. Zevallos, J.P. Sturgis, E.M. Li, G. Levi, F. Zhang, Z.-F. Morgenstern, H. Smith, E. Lazarus, P. La Vecchia, C. Garavello, W. Chen, C. Schwartz, S.M. Zheng, T. Vaughan, T.L. Kelsey, K. McClean, M. Benhamou, S. Hayes, R.B. Purdue, M.P. Gillison, M. Schantz, S. Yu, G.-P. Chuang, S.-C. Boffetta, P. Hashibe, M. Yuan-Chin, A.L. Edefonti, V.
Abstract: Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk. © 2020, The Author(s), under exclusive licence to Cancer Research UK.
Published: 2020

13. Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Author: Khetan, P. Boffetta, P. Luce, D. Stucker, I. Curado, M.P. Menezes, A. Wunsch-Filho, V. Ahrens, W. Lagiou, P. Serraino, D. Richiardi, L. Kjaerheim, K. Conway, D. Thomson, P. Muscat, J. Mates, D. Ramroth, H. Menvielle, G. Vaughan, T.L. Brenner, H. Lee, Y.-C.A. La Vecchia, C. Hashibe, M. Hashim, D.
Abstract: Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship. Copyright © 2019 American College of Occupational and Environmental Medicine.
Published: 2019

14. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Author: Chang, C. -P., Chang, S. -C., Chuang, S. -C., Berthiller, J., Ferro, G., Matsuo, K., Wunsch-Filho, V., Toporcov, T. N., de Carvalho, M. B., La Vecchia, C., Olshan, A. F., Zevallos, J. P., Serraino, D., Muscat, J., Sturgis, E. M., Li, G., Morgenstern, H., Levi, F., Dal Maso, L., Smith, E., Kelsey, K., Mcclean, M., Vaughan, T. L., Lazarus, P., Ramroth, H., Chen, C., Schwartz, S. M., Winn, D. M., Bosetti, C., Edefonti, V., Garavello, W., Negri, E., Hayes, R. B., Purdue, M. P., Boccia, Stefania, Cadoni, Gabriella, Shangina, O., Koifman, R., Curado, M. P., Vilensky, M., Swiatkowska, B., Herrero, R., Franceschi, S., Benhamou, S., Fernandez, L., Menezes, A. M. B., Daudt, A. W., Mates, D., Schantz, S., Yu, G. -P., Lissowska, J., Brenner, H., Fabianova, E., Rudnai, P., Brennan, P., Boffetta, P., Zhang, Z. -F., Hashibe, M., Lee, Y. -C. A., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chang, C. -P., Chang, S. -C., Chuang, S. -C., Berthiller, J., Ferro, G., Matsuo, K., Wunsch-Filho, V., Toporcov, T. N., de Carvalho, M. B., La Vecchia, C., Olshan, A. F., Zevallos, J. P., Serraino, D., Muscat, J., Sturgis, E. M., Li, G., Morgenstern, H., Levi, F., Dal Maso, L., Smith, E., Kelsey, K., Mcclean, M., Vaughan, T. L., Lazarus, P., Ramroth, H., Chen, C., Schwartz, S. M., Winn, D. M., Bosetti, C., Edefonti, V., Garavello, W., Negri, E., Hayes, R. B., Purdue, M. P., Boccia, Stefania, Cadoni, Gabriella, Shangina, O., Koifman, R., Curado, M. P., Vilensky, M., Swiatkowska, B., Herrero, R., Franceschi, S., Benhamou, S., Fernandez, L., Menezes, A. M. B., Daudt, A. W., Mates, D., Schantz, S., Yu, G. -P., Lissowska, J., Brenner, H., Fabianova, E., Rudnai, P., Brennan, P., Boffetta, P., Zhang, Z. -F., Hashibe, M., Lee, Y. -C. A., Boccia S. (ORCID:0000-0002-1864-749X), and Cadoni G. (ORCID:0000-0001-8244-784X)
Abstract: Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.
Published: 2019

15. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author: Di Credico, G., Edefonti, V., Polesel, J., Pauli, F., Torelli, N., Serraino, D., Negri, E., Luce, D., Stucker, I., Matsuo, K., Brennan, P., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Holcatova, I., Ahrens, W., Lagiou, Pagona, Simonato, L., Richiardi, L., Healy, C., Kjaerheim, K., Conway, D. I., Macfarlane, T. V., Thomson, P., Agudo, A., Znaor, A., Boaventura Rios, L. F., Toporcov, T. N., Franceschi, S., Herrero, R., Muscat, J., Olshan, A. F., Zevallos, J. P., La Vecchia, C., Winn, D. M., Sturgis, E. M., Li, G., Fabianova, E., Lissowska, J., Mates, D., Rudnai, P., Shangina, O., Swiatkowska, B., Moysich, K., Zhang, Z. -F., Morgenstern, H., Levi, F., Smith, E., Lazarus, P., Bosetti, C., Garavello, W., Kelsey, K., Mcclean, M., Ramroth, H., Chen, C., Schwartz, S. M., Vaughan, T. L., Zheng, T., Menvielle, G., Boccia, Stefania, Cadoni, Gabriella, Hayes, R. B., Purdue, M., Gillison, M., Schantz, S., Yu, G. -P., Brenner, H., D'Souza, G., Gross, N. D., Chuang, S. -C., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Dal Maso, L., Lagiou P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Boffetta P., Di Credico, G., Edefonti, V., Polesel, J., Pauli, F., Torelli, N., Serraino, D., Negri, E., Luce, D., Stucker, I., Matsuo, K., Brennan, P., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Holcatova, I., Ahrens, W., Lagiou, Pagona, Simonato, L., Richiardi, L., Healy, C., Kjaerheim, K., Conway, D. I., Macfarlane, T. V., Thomson, P., Agudo, A., Znaor, A., Boaventura Rios, L. F., Toporcov, T. N., Franceschi, S., Herrero, R., Muscat, J., Olshan, A. F., Zevallos, J. P., La Vecchia, C., Winn, D. M., Sturgis, E. M., Li, G., Fabianova, E., Lissowska, J., Mates, D., Rudnai, P., Shangina, O., Swiatkowska, B., Moysich, K., Zhang, Z. -F., Morgenstern, H., Levi, F., Smith, E., Lazarus, P., Bosetti, C., Garavello, W., Kelsey, K., Mcclean, M., Ramroth, H., Chen, C., Schwartz, S. M., Vaughan, T. L., Zheng, T., Menvielle, G., Boccia, Stefania, Cadoni, Gabriella, Hayes, R. B., Purdue, M., Gillison, M., Schantz, S., Yu, G. -P., Brenner, H., D'Souza, G., Gross, N. D., Chuang, S. -C., Boffetta, Paolo, Hashibe, M., Lee, Y. -C. A., Dal Maso, L., Lagiou P., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), and Boffetta P.
Abstract: Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
Published: 2019

16. Materials science: The hardest known oxide

Author: Dubrovinsky, L. S., Dubrovinskaia, N. A., Swamy, V., Muscat, J., Harrison, N. M., Ahuja, R., Holm, B., and Johansson, B.
Published: 2001

17. Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)

Author: Ferro, A. Morais, S. Rota, M. Pelucchi, C. Bertuccio, P. Bonzi, R. Galeone, C. Zhang, Z.-F. Matsuo, K. Ito, H. Hu, J. Johnson, K.C. Yu, G.-P. Palli, D. Ferraroni, M. Muscat, J. Malekzadeh, R. Ye, W. Song, H. Zaridze, D. Maximovitch, D. Fernández de Larrea, N. Kogevinas, M. Vioque, J. Navarrete-Muñoz, E.M. Pakseresht, M. Pourfarzi, F. Wolk, A. Orsini, N. Bellavia, A. Håkansson, N. Mu, L. Pastorino, R. Kurtz, R.C. Derakhshan, M.H. Lagiou, A. Lagiou, P. Boffetta, P. Boccia, S. Negri, E. La Vecchia, C. Peleteiro, B. Lunet, N.
Abstract: Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies. Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07–1.36) vs. 1.10 (0.99–1.23)] and more heterogeneous (I 2 : 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias. Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes. © 2018 Elsevier Ltd
Published: 2018

18. Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

Author: Praud, D. Rota, M. Pelucchi, C. Bertuccio, P. Rosso, T. Galeone, C. Zhang, Z.-F. Matsuo, K. Ito, H. Hu, J. Johnson, K.C. Yu, G.-P. Palli, D. Ferraroni, M. Muscat, J. Lunet, N. Peleteiro, B. Malekzadeh, R. Ye, W. Song, H. Zaridze, D. Maximovitch, D. Aragonés, N. Castaño-Vinyals, G. Vioque, J. Navarrete-Muñoz, E.M. Pakseresht, M. Pourfarzi, F. Wolk, A. Orsini, N. Bellavia, A. Håkansson, N. Mu, L. Pastorino, R. Kurtz, R.C. Derakhshan, M.H. Lagiou, A. Lagiou, P. Boffetta, P. Boccia, S. Negri, E. La Vecchia, C.
Abstract: Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend
Published: 2018

19. Tobacco smoking and gastric cancer: Meta-Analyses of published data versus pooled analyses of individual participant data (StoP Project)

Author: Ferro, A. Morais, S. Rota, M. Pelucchi, C. Bertuccio, P. Bonzi, R. Galeone, C. Zhang, Z.-F. Matsuo, K. Ito, H. Hu, J. Johnson, K.C. Yuo, G.-P. Palli, D. Ferraroni, M. Muscat, J. Malekzadeh, R. Ye, W. Song, H. Zaridze, D. Maximovitch, D. Aragonés, N. Castaño-Vinyals, G. Vioque, J. Navarrete-Muñoz, E.M. Pakseresht, M. Pourfarzi, F. Wolk, A. Orsini, N. Bellavia, A. Håkansson, N. Mu, L. Pastorino, R. Kurtz, R.C. Derakhshan, M.H. Lagiou, A. Lagioul, P. Boffetta, P. Boccia, S. Negri, E. Vecchia, C.L. Peleteiro, B. Lunet, N.
Abstract: Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-Analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from conventional meta-Analyses. We compared results from individual participant data pooled-Analyses, including the studies in the Stomach Cancer Pooling (StoP) Project, with conventional meta-Analyses carried out using only data available in previously published reports from the same studies. Fromthe 23 studies in the StoP Project, 20 had published reports with information on smoking and gastric cancer, but only six had specific data for gastric cardia cancer and seven had data on the daily number of cigarettes smoked. Compared to the results obtained with the StoP database, conventional meta-Analyses overvalued the relation between ever smoking (summary odds ratios ranging from 7% higher for all studies to 22% higher for the risk of gastric cardia cancer) and yielded less precise summary estimates (SE ≤2.4 times higher). Additionally, funnel plot asymmetry and corresponding hypotheses tests were suggestive of publication bias. Conventional meta-Analyses and individual participant data pooled-Analyses reached similar conclusions on the direction of the association between smoking and gastric cancer. However, published data tended to overestimate the magnitude of the effects, possibly due to publication biases and limited the analyses by different levels of exposure or cancer subtypes. European Journal of Cancer Prevention 27:197-204 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Published: 2018

20. The retrofitting and upgrading of the administration centre in Victoria, Gozo – minimising the energy consumption through the implementation of energy efficient measures

Author: Cordina, C., Muscat, J., Yousif, Charles, and Engineering Sustainability & Sustainable Energy 2018 (ESSE ’18) Conference
Subjects: Architecture and energy conservation -- Malta -- Victoria, Buildings -- Retrofitting -- Malta -- Victoria, Sustainable architecture -- Malta -- Victoria
Abstract: The retrofitting of existing buildings offers considerable opportunities for reducing the global energy consumption and the resulting greenhouse gas emissions. Achieving a higher energy efficiency in existing buildings is considered as one of the most favourable approaches towards implementing sustainability in the built environment. The study in this paper is divided into two sections. In the first part, the current situation present at the Ministry for Gozo is studied and the energy consumption patterns and the inefficiencies leading to these patterns are assessed, in order to determine the state of the building’s energy performance. The second part of the paper analyses possible recommendations that could be implemented to render the Ministry for Gozo’s Administration Centre more energy efficient., peer-reviewed
Published: 2018

21. Alcohol consumption and gastric cancer risk—A pooled analysis within the StoP project consortium

Author: Rota, M. Pelucchi, C. Bertuccio, P. Matsuo, K. Zhang, Z.-F. Ito, H. Hu, J. Johnson, K.C. Palli, D. Ferraroni, M. Yu, G.-P. Muscat, J. Lunet, N. Peleteiro, B. Ye, W. Song, H. Zaridze, D. Maximovitch, D. Guevara, M. Fernández-Villa, T. Vioque, J. Navarrete-Muñoz, E.M. Wolk, A. Orsini, N. Bellavia, A. Håkansson, N. Mu, L. Persiani, R. Kurtz, R.C. Lagiou, A. Lagiou, P. Galeone, C. Bonzi, R. Boffetta, P. Boccia, S. Negri, E. La Vecchia, C.
Abstract: An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the “Stomach cancer Pooling (StoP) Project,” a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds-ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects meta-regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08–1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29–1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35–2.58) as compared with current smokers (OR 1.14, 95% CI 0.93–1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11–2.34) than in non-cardia (OR 1.28, 95% CI 1.13–1.45) gastric cancers, and in intestinal-type (OR 1.54, 95% CI 1.20–1.97) than in diffuse-type (OR 1.29, 95% CI 1.05–1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16–2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95–3.01). Our collaborative pooled-analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk. © 2017 UICC
Published: 2017

22. Domestic Asbestos Exposure, Lung Fibre Burden, and Pleural Mesothelioma in a Housewife

Author: Huncharek, M., Capotorto, J. V., and Muscat, J.
Published: 1989

23. Pleural Mesothelioma in a Lift Mechanic

Author: Huncharek, M., Muscat, J., and Capotorto, J.
Published: 1989

24. Pleural Mesothelioma in a Brake Mechanic

Author: Huncharek, M., Muscat, J., and Capotorto, J. V.
Published: 1989

25. Pleural Mesothelioma in a Non-Shipyard Electrician

Author: Huncharek, M. and Muscat, J.
Published: 1990

26. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Author: Conway, D.I. Brenner, D.R. McMahon, A.D. Macpherson, L.M.D. Agudo, A. Ahrens, W. Bosetti, C. Brenner, H. Castellsague, X. Chen, C. Curado, M.P. Curioni, O.A. Maso, L.D. Daudt, A.W. De Gois Filho, J.F. D'Souza, G. Edefonti, V. Fabianova, E. Fernandez, L. Franceschi, S. Gillison, M. Hayes, R.B. Healy, C.M. Herrero, R. Holcatova, I. Jayaprakash, V. Kelsey, K. Kjaerheim, K. Koifman, S. La Vecchia, C. Lagiou, P. Lazarus, P. Levi, F. Lissowska, J. Luce, D. Macfarlane, T.V. Mates, D. Matos, E. McClean, M. Menezes, A.M. Menvielle, G. Merletti, F. Morgenstern, H. Moysich, K. Müller, H. Muscat, J. Olshan, A.F. Purdue, M.P. Ramroth, H. Richiardi, L. Rudnai, P. Schantz, S. Schwartz, S.M. Shangina, O. Simonato, L. Smith, E. Stucker, I. Sturgis, E.M. Szeszenia-Dabrowska, N. Talamini, R. Thomson, P. Vaughan, T.L. Wei, Q. Winn, D.M. Wunsch-Filho, V. Yu, G.-P. Zhang, Z.-F. Zheng, T. Znaor, A. Boffetta, P. Chuang, S.-C. Ghodrat, M. Lee, Y.-C.A. Hashibe, M. Brennan, P.
Abstract: Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR 5 2.50; 95% CI 5 2.02-3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR 5 1.61; 95% CI 5 1.13-2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels. © 2014 UICC.
Published: 2015

27. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis.

Author: Berthiller, J, Straif, K, Agudo, A, Ahrens, W, Bezerra Dos Santos, A, Boccia, Stefania, Cadoni, Gabriella, Canova, Chiara, Castellsague, X, Chen, Chen, Conway, D, Curado, Mp, Dal Maso, L, Daudt, Aw, Fabianova, E, Fernandez, L, Franceschi, S, Fukuyama, Ee, Hayes, Rb, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, S, Lagiou, P, La Vecchia, C, Lazarus, P, Levi, F, Lissowska, J, Macfarlane, T, Mates, D, Mcclean, M, Menezes, A, Merletti, F, Morgenstern, H, Muscat, J, Olshan, Af, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, Sm, Serraino, D, Shangina, O, Smith, E, Sturgis, Em, Szeszenia Dabrowska, N, Thomson, P, Vaughan, Tl, Vilensky, M, Wei, Q, Winn, Dm, Wünsch Filho, V, Zhang, Zf, Znaor, A, Ferro, Giorgia, Brennan, P, Boffetta, Paolo, Hashibe, M, Lee, Yc50, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Berthiller, J, Straif, K, Agudo, A, Ahrens, W, Bezerra Dos Santos, A, Boccia, Stefania, Cadoni, Gabriella, Canova, Chiara, Castellsague, X, Chen, Chen, Conway, D, Curado, Mp, Dal Maso, L, Daudt, Aw, Fabianova, E, Fernandez, L, Franceschi, S, Fukuyama, Ee, Hayes, Rb, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, S, Lagiou, P, La Vecchia, C, Lazarus, P, Levi, F, Lissowska, J, Macfarlane, T, Mates, D, Mcclean, M, Menezes, A, Merletti, F, Morgenstern, H, Muscat, J, Olshan, Af, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, Sm, Serraino, D, Shangina, O, Smith, E, Sturgis, Em, Szeszenia Dabrowska, N, Thomson, P, Vaughan, Tl, Vilensky, M, Wei, Q, Winn, Dm, Wünsch Filho, V, Zhang, Zf, Znaor, A, Ferro, Giorgia, Brennan, P, Boffetta, Paolo, Hashibe, M, Lee, Yc50, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)
Abstract: BACKGROUND: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. METHODS: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day. RESULTS: Smoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. CONCLUSION: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC. © The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association. KEYWORDS: Head and neck cancer; low frequency cigarette smoking; pooled analysis; risk factors
Published: 2016

28. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

Author: Bosetti, C. Rosato, V. Li, D. Silverman, D. Petersen, G.M. Bracci, P.M. Neale, R.E. Muscat, J. Anderson, K. Gallinger, S. Olson, S.H. Miller, A.B. Bas Bueno-de-Mesquita, H. Scelo, G. Janout, V. Holcatova, I. Lagiou, P. Serraino, D. Lucenteforte, E. Fabianova, E. Baghurst, P.A. Zatonski, W. Foretova, L. Fontham, E. Bamlet, W.R. Holly, E.A. Negri, E. Hassan, M. Prizment, A. Cotterchio, M. Cleary, S. Kurtz, R.C. Maisonneuve, P. Trichopoulos, D. Polesel, J. Duell, E.J. Boffetta, P. La Vecchia, C. Ghadirian, P.
Abstract: Background: Type 2 diabetes mellitus has been associated with an excess risk of pancreatic cancer, but the magnitude of the risk and the time–risk relationship are unclear, and there is limited information on the role of antidiabetic medications. Patients and methods: We analyzed individual-level data from 15 case–control studies within the Pancreatic Cancer Case-Control Consortium, including 8305 cases and 13 987 controls. Pooled odds ratios (ORs) were estimated from multiple logistic regression models, adjusted for relevant covariates. Results: Overall, 1155 (15%) cases and 1087 (8%) controls reported a diagnosis of diabetes 2 or more years before cancer diagnosis (or interview, for controls), corresponding to an OR of 1.90 (95% confidence interval, CI, 1.72–2.09). Consistent risk estimates were observed across strata of selected covariates, including body mass index and tobacco smoking. Pancreatic cancer risk decreased with duration of diabetes, but a significant excess risk was still evident 20 or more years after diabetes diagnosis (OR 1.30, 95% CI 1.03–1.63). Among diabetics, long duration of oral antidiabetic use was associated with a decreased pancreatic cancer risk (OR 0.31, 95% CI 0.14–0.69, for ≥15 years). Conversely, insulin use was associated with a pancreatic cancer risk in the short term (OR 5.60, 95% CI 3.75–8.35, for
Published: 2014

29. Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.

Author: Huang, R., Wei, Y., Hung, R.J., Liu, G., Su, L., Zhang, R., Zong, X., Zhang, Z.F., Morgenstern, H., Bruske, I., Heinrich, J., Hong, Y.C., Kim, J.H., Cote, M., Wenzlaff, A., Schwartz, A.G., Stucker, I., McLaughlin, J., Marcus, M.W., Davies, M.P., Liloglou, T., Field, J.K., Matsuo, K., Barnett, M., Thornquist, M., Goodman, G., Wang, Y., Chen, S., Yang, P., Duell, E.J., Andrew, A.S., Lazarus, P., Muscat, J., Woll, P., Horsman, J., Dawn Teare, M., Flugelman, A., Rennert, G., Zhang, Y, Brenner, H., Stegmaier, C., Heijden, E. van der, Aben, K.K.H., Kiemeney, L.A., Barros-Dios, J., Perez-Rios, M., Ruano-Ravina, A., Caporaso, N.E., Bertazzi, P.A., Landi, M.T., Dai, J., Shen, H., Fernandez-Tardon, G., Rodriguez-Suarez, M., Tardon, A., Christiani, D.C., Huang, R., Wei, Y., Hung, R.J., Liu, G., Su, L., Zhang, R., Zong, X., Zhang, Z.F., Morgenstern, H., Bruske, I., Heinrich, J., Hong, Y.C., Kim, J.H., Cote, M., Wenzlaff, A., Schwartz, A.G., Stucker, I., McLaughlin, J., Marcus, M.W., Davies, M.P., Liloglou, T., Field, J.K., Matsuo, K., Barnett, M., Thornquist, M., Goodman, G., Wang, Y., Chen, S., Yang, P., Duell, E.J., Andrew, A.S., Lazarus, P., Muscat, J., Woll, P., Horsman, J., Dawn Teare, M., Flugelman, A., Rennert, G., Zhang, Y, Brenner, H., Stegmaier, C., Heijden, E. van der, Aben, K.K.H., Kiemeney, L.A., Barros-Dios, J., Perez-Rios, M., Ruano-Ravina, A., Caporaso, N.E., Bertazzi, P.A., Landi, M.T., Dai, J., Shen, H., Fernandez-Tardon, G., Rodriguez-Suarez, M., Tardon, A., and Christiani, D.C.
Abstract: 1 november 2015, Contains fulltext : 156878.pdf (publisher's version ) (Open Access)
Published: 2015

30. The stomach cancer pooling (StoP) project: study design and presentation

Author: Pelucchi, C, Lunet, N, Boccia, Stefania, Zhang, Z, Praud, D, Boffetta, P, Levi, F, Matsuo, K, Ito, H, Hu, J, Johnson, Kc, Ferraroni, M, Yu, G, Peleteiro, B, Malekzadeh, R, Derakhshan, Mh, Ye, W, Zaridze, D, Maximovitch, D, Aragonés, N, Martín, V, Pakseresht, M, Pourfarzi, F, Bellavia, A, Orsini, N, Wolk, A, Mu, L, Arzani, Dario, Kurtz, Rc, Lagiou, P, Trichopoulos, D, Muscat, J, La Vecchia, C, Negri, E., Boccia, Stefania (ORCID:0000-0002-1864-749X), Pelucchi, C, Lunet, N, Boccia, Stefania, Zhang, Z, Praud, D, Boffetta, P, Levi, F, Matsuo, K, Ito, H, Hu, J, Johnson, Kc, Ferraroni, M, Yu, G, Peleteiro, B, Malekzadeh, R, Derakhshan, Mh, Ye, W, Zaridze, D, Maximovitch, D, Aragonés, N, Martín, V, Pakseresht, M, Pourfarzi, F, Bellavia, A, Orsini, N, Wolk, A, Mu, L, Arzani, Dario, Kurtz, Rc, Lagiou, P, Trichopoulos, D, Muscat, J, La Vecchia, C, Negri, E., and Boccia, Stefania (ORCID:0000-0002-1864-749X)
Abstract: Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the 'Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics.
Published: 2015

31. Diet and the risk of head and neck cancer: A pooled analysis in the INHANCE consortium

Author: Chuang, S.-C. Jenab, M. Heck, J.E. Bosetti, C. Talamini, R. Matsuo, K. Castellsague, X. Franceschi, S. Herrero, R. Winn, D.M. Vecchia, C.L. Morgenstern, H. Zhang, Z.-F. Levi, F. Maso, L.D. Kelsey, K. McClean, M.D. Vaughan, T. Lazarus, P. Muscat, J. Ramroth, H. Chen, C. Schwartz, S.M. Eluf-Neto, J. Hayes, R.B. Purdue, M. Boccia, S. Cadoni, G. Zaridze, D. Koifman, S. Curado, M.P. Ahrens, W. Benhamou, S. Matos, E. Lagiou, P. Szeszenia-Dabrowska, N. Olshan, A.F. Fernandez, L. Menezes, A. Agudo, A. Daudt, A.W. Merletti, F. MacFarlane, G.J. Kjaerheim, K. Mates, D. Holcatova, I. Schantz, S. Yu, G.-P. Simonato, L. Brenner, H. Mueller, H. Conway, D.I. Thomson, P. Fabianova, E. Znaor, A. Rudnai, P. Healy, C.M. Ferro, G. Brennan, P. Boffetta, P. Hashibe, M.
Abstract: We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p trend < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p trend = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p trend = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p trend < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97). © 2011 Springer Science+Business Media B.V.
Published: 2012

32. Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Author: Chuang, S.-C. Agudo, A. Ahrens, W. Anantharaman, D. Benhamou, S. Boccia, S. Chen, C. Conway, D.I. Fabianova, E. Hayes, R.B. Healy, C.M. Holcatova, I. Kjaerheim, K. Lagiou, P. Lazarus, P. Macfarlane, T.V. Mahimkar, M.B. Mates, D. Matsuo, K. Merletti, F. Metspalu, A. Morgenstern, H. Muscat, J. Cadoni, G. Olshan, A.F. Purdue, M. Ramroth, H. Rudnai, P. Schwartz, S.M. Simonato, L. Smith, E.M. Sturgis, E.M. Szeszenia-Dabrowska, N. Talamini, R. Thomson, P. Wei, Q. Zaridze, D. Zhang, Z.-F. Znaor, A. Brennan, P. Boffetta, P. Hashibe, M.
Abstract: Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (
Published: 2011

33. Review on solving the forward problem in EEG source analysis

Author: Hallez, Hans, Vanrumste, Bart, GRECH, R, MUSCAT, J, DE CLERCQ, W, D'Asseler, Yves, CAMILLERI, K, FABRI, S, VAN HUFFEL, S, and Lemahieu, Ignace
Subjects: Technology and Engineering
Abstract: Background: The aim of electroencephalogram ( EEG) source localization is to find the brain areas responsible for EEG waves of interest. It consists of solving forward and inverse problems. The forward problem is solved by starting from a given electrical source and calculating the potentials at the electrodes. These evaluations are necessary to solve the inverse problem which is defined as finding brain sources which are responsible for the measured potentials at the EEG electrodes. Methods: While other reviews give an extensive summary of the both forward and inverse problem, this review article focuses on different aspects of solving the forward problem and it is intended for newcomers in this research field. Results: It starts with focusing on the generators of the EEG: the post-synaptic potentials in the apical dendrites of pyramidal neurons. These cells generate an extracellular current which can be modeled by Poisson's differential equation, and Neumann and Dirichlet boundary conditions. The compartments in which these currents flow can be anisotropic ( e. g. skull and white matter). In a three-shell spherical head model an analytical expression exists to solve the forward problem. During the last two decades researchers have tried to solve Poisson's equation in a realistically shaped head model obtained from 3D medical images, which requires numerical methods. The following methods are compared with each other: the boundary element method (BEM), the finite element method (FEM) and the finite difference method (FDM). In the last two methods anisotropic conducting compartments can conveniently be introduced. Then the focus will be set on the use of reciprocity in EEG source localization. It is introduced to speed up the forward calculations which are here performed for each electrode position rather than for each dipole position. Solving Poisson's equation utilizing FEM and FDM corresponds to solving a large sparse linear system. Iterative methods are required to solve these sparse linear systems. The following iterative methods are discussed: successive over-relaxation, conjugate gradients method and algebraic multigrid method. Conclusion: Solving the forward problem has been well documented in the past decades. In the past simplified spherical head models are used, whereas nowadays a combination of imaging modalities are used to accurately describe the geometry of the head model. Efforts have been done on realistically describing the shape of the head model, as well as the heterogenity of the tissue types and realistically determining the conductivity. However, the determination and validation of the in vivo conductivity values is still an important topic in this field. In addition, more studies have to be done on the influence of all the parameters of the head model and of the numerical techniques on the solution of the forward problem.
Published: 2007

34. High-pressure phases of FeTiO3 from first principles

Author: Wilson, NC, Russo, SP, Muscat, J, and Harrison, NM
Subjects: GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract: Published version
Published: 2005

35. PB.17. Are patients who have had total body irradiation at similar risk of breast cancer to those having mantle radiotherapy? A review of the evidence and suggestions on breast imaging surveillance

Author: Muscat, J, primary and Rubin, G, additional
Published: 2014
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36. ED-16 * HFE POLYMORPHISMS AFFECT SURVIVAL OF BRAIN TUMOR PATIENTS

Author: Lee, S., primary, Slagle-Webb, B., additional, Sheehan, J., additional, Zhu, J., additional, Muscat, J., additional, Glantz, M., additional, and Connor, J., additional
Published: 2014
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37. 72 * DEPRIVATION OF LIBERTY SAFEGUARDS: TREATING VULNERABLE PATIENTS

Author: Chowdhury, T., primary, Muscat, J., additional, and Garbharran, U., additional
Published: 2014
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38. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author: Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, Af, Winn, Dm, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, M, Vaughan, Tl, Lazarus, P, Purdue, Mp, Hayes, Rb, Chen, C, Schwartz, Sm, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G, Schantz, S, Simonato, L, Brenner, H, Conway, Di, Macfarlane, Tv, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S, Lee, Ya, Hashibe, M, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Boccia, Stefania (ORCID:0000-0002-1864-749X), Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, P, Luce, D, Stucker, I, Matsuo, K, Talamini, R, La Vecchia, C, Olshan, Af, Winn, Dm, Herrero, R, Franceschi, S, Castellsague, X, Muscat, J, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, M, Vaughan, Tl, Lazarus, P, Purdue, Mp, Hayes, Rb, Chen, C, Schwartz, Sm, Shangina, O, Koifman, S, Ahrens, W, Matos, E, Lagiou, P, Lissowska, J, Szeszenia Dabrowska, N, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Richiardi, L, Kjaerheim, K, Mates, D, Betka, J, Yu, G, Schantz, S, Simonato, L, Brenner, H, Conway, Di, Macfarlane, Tv, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, C, Boffetta, P, Chuang, S, Lee, Ya, Hashibe, M, Boccia, Stefania, Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), and Boccia, Stefania (ORCID:0000-0002-1864-749X)
Abstract: Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.
Published: 2013

39. Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author: Wyss, A, Hashibe, M, Chuang, S, Lee, Ya, Zhang, Z, Yu, G, Winn, Dm, Wei, Q, Talamini, R, Szeszenia Dabrowska, N, Sturgis, Em, Smith, E, Shangina, O, Schwartz, Sm, Schantz, S, Rudnai, P, Purdue, Mp, Eluf Neto, J, Muscat, J, Morgenstern, H, Michaluart, P, Menezes, A, Matos, E, Mates, In, Lissowska, J, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Herrero, R, Hayes, Rb, Franceschi, S, Wunsch Filho, V, Fernandez, L, Fabianova, E, Daudt, Aw, Dal Maso, L, Curado, Mp, Chen, C, Castellsague, X, De Carvalho, Mb, Cadoni, Gabriella, Boccia, Stefania, Brennan, P, Boffetta, P, Olshan, Af, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Wyss, A, Hashibe, M, Chuang, S, Lee, Ya, Zhang, Z, Yu, G, Winn, Dm, Wei, Q, Talamini, R, Szeszenia Dabrowska, N, Sturgis, Em, Smith, E, Shangina, O, Schwartz, Sm, Schantz, S, Rudnai, P, Purdue, Mp, Eluf Neto, J, Muscat, J, Morgenstern, H, Michaluart, P, Menezes, A, Matos, E, Mates, In, Lissowska, J, Levi, F, Lazarus, P, La Vecchia, C, Koifman, S, Herrero, R, Hayes, Rb, Franceschi, S, Wunsch Filho, V, Fernandez, L, Fabianova, E, Daudt, Aw, Dal Maso, L, Curado, Mp, Chen, C, Castellsague, X, De Carvalho, Mb, Cadoni, Gabriella, Boccia, Stefania, Brennan, P, Boffetta, P, Olshan, Af, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)
Abstract: Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend ≤ 0.0001). Odds ratios for cigar and pipe smoking were not elevated among ever cigarette smokers. Head and neck cancer risk was elevated for those who reported exclusive cigar smoking (odds ratio = 3.49, 95% CI: 2.58, 4.73) or exclusive pipe smoking (odds ratio = 3.71, 95% CI: 2.59, 5.33). These results suggest that cigar and pipe smoking are independently associated with increased risk of head and neck cancers
Published: 2013

40. Materials science - The hardest known oxide

Author: Dubrovinsky, LS, Dubrovinskaia, NA, Swamy, V, Muscat, J, Harrison, NM, Ahuja, R, Holm, B, and Johansson, B
Published: 2001

41. History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium

Author: Stott Miller, M, Chen, Chen, Chuang, S, Lee, Ya, Boccia, Stefania, Brenner, H, Cadoni, Gabriella, Dal Maso, L, La Vecchia, C, Lazarus, P, Levi, F, Matsuo, K, Morgenstern, H, Müller, H, Muscat, J, Olshan, Af, Purdue, Mp, Serraino, D, Vaughan, Tl, Zhang, Z, Boffetta, P, Hashibe, M, Schwartz, Sm, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Stott Miller, M, Chen, Chen, Chuang, S, Lee, Ya, Boccia, Stefania, Brenner, H, Cadoni, Gabriella, Dal Maso, L, La Vecchia, C, Lazarus, P, Levi, F, Matsuo, K, Morgenstern, H, Müller, H, Muscat, J, Olshan, Af, Purdue, Mp, Serraino, D, Vaughan, Tl, Zhang, Z, Boffetta, P, Hashibe, M, Schwartz, Sm, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)
Abstract: Background: A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention. Methods: We pooled data from 12 case control studies including 6,448 cases and 13,747 controls, and estimated OR and 95% CI for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, and body mass index. Results: We observed a weak association between diabetes and the incidence of HNC overall (OR, 1.09; 95% CI: 0.95-1.24). However, we observed a modest association among never smokers (OR, 1.59; 95% CI: 1.22-2.07), and no association among ever smokers (OR, 0.96; 95% CI: 0.83-1.11); likelihood ratio test for interaction P = 0.001 Conclusion: A history of diabetes was weakly associated with HNC overall, but we observed evidence of effect modification by smoking status, with a positive association among those who never smoked cigarettes. Impact: This study suggests that glucose metabolism abnormalities may be a HNC risk factor in subgroups of the population. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNC risk, possibly providing new strategies in the prevention of HNC
Published: 2012

42. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Author: Chuang, S, Jenab, M, Heck, Je, Bosetti, C, Talamini, R, Matsuo, K, Castellsague, X, Franceschi, S, Herrero, R, Winn, Dm, La Vecchia, C, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, Md, Vaughan, T, Lazarus, P, Muscat, J, Ramroth, H, Chen, Chen, Schwartz, Sm, Eluf Neto, J, Hayes, Rb, Purdue, M, Boccia, Stefania, Cadoni, Gabriella, Zaridze, D, Koifman, S, Curado, Mp, Ahrens, W, Benhamou, S, Matos, E, Lagiou, P, Szeszenia Dabrowska, N, Olshan, Af, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Merletti, F, Macfarlane, Gj, Kjaerheim, K, Mates, D, Holcatova, I, Schantz, S, Yu, G, Simonato, L, Brenner, H, Mueller, H, Conway, Di, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, Cm, Ferro, Giorgia, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Chuang, S, Jenab, M, Heck, Je, Bosetti, C, Talamini, R, Matsuo, K, Castellsague, X, Franceschi, S, Herrero, R, Winn, Dm, La Vecchia, C, Morgenstern, H, Zhang, Z, Levi, F, Dal Maso, L, Kelsey, K, Mcclean, Md, Vaughan, T, Lazarus, P, Muscat, J, Ramroth, H, Chen, Chen, Schwartz, Sm, Eluf Neto, J, Hayes, Rb, Purdue, M, Boccia, Stefania, Cadoni, Gabriella, Zaridze, D, Koifman, S, Curado, Mp, Ahrens, W, Benhamou, S, Matos, E, Lagiou, P, Szeszenia Dabrowska, N, Olshan, Af, Fernandez, L, Menezes, A, Agudo, A, Daudt, Aw, Merletti, F, Macfarlane, Gj, Kjaerheim, K, Mates, D, Holcatova, I, Schantz, S, Yu, G, Simonato, L, Brenner, H, Mueller, H, Conway, Di, Thomson, P, Fabianova, E, Znaor, A, Rudnai, P, Healy, Cm, Ferro, Giorgia, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)
Abstract: We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).
Published: 2012

43. Erratum: Recreational physical activity and risk of head and neck cancer: A pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium (European Journal of Epidemiology DOI: 10.1007/s10654-011- 9612-3)

Author: Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., Boccia S. (ORCID:0000-0002-1864-749X), Nicolotti, N., Chuang, S. -C., Cadoni, G., Arzani, D., Petrelli, L., Bosetti, C., Brenner, H., Hosono, S., La Vecchia, C., Talamini, R., Matsuo, K., Muller, H., Muscat, J., Paludetti, G., Ricciardi, G., Boffetta, P., Hashibe, M., Boccia, S., Nicolotti N., Cadoni G. (ORCID:0000-0001-8244-784X), Petrelli L., Paludetti G. (ORCID:0000-0003-2480-1243), Ricciardi G. (ORCID:0000-0002-5655-688X), Boffetta P., and Boccia S. (ORCID:0000-0002-1864-749X)
Published: 2011

44. Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium

Author: Chuang, S, Agudo, A, Ahrens, W, Anantharaman, D, Benhamou, S, Boccia, Stefania, Chen, Chen, Conway, Di, Fabianova, E, Hayes, Rb, Healy, Cm, Holcatova, I, Kjaerheim, K, Lagiou, P, Lazarus, P, Macfarlane, Tv, Mahimkar, Mb, Mates, D, Matsuo, K, Merletti, F, Metspalu, A, Morgenstern, H, Muscat, J, Cadoni, Gabriella, Olshan, Af, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, Sm, Simonato, L, Smith, Em, Sturgis, Em, Szeszenia Dabrowska, N, Talamini, R, Thomson, P, Wei, Q, Zaridze, D, Zhang, Z, Znaor, A, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Chuang, S, Agudo, A, Ahrens, W, Anantharaman, D, Benhamou, S, Boccia, Stefania, Chen, Chen, Conway, Di, Fabianova, E, Hayes, Rb, Healy, Cm, Holcatova, I, Kjaerheim, K, Lagiou, P, Lazarus, P, Macfarlane, Tv, Mahimkar, Mb, Mates, D, Matsuo, K, Merletti, F, Metspalu, A, Morgenstern, H, Muscat, J, Cadoni, Gabriella, Olshan, Af, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, Sm, Simonato, L, Smith, Em, Sturgis, Em, Szeszenia Dabrowska, N, Talamini, R, Thomson, P, Wei, Q, Zaridze, D, Zhang, Z, Znaor, A, Brennan, P, Boffetta, P, Hashibe, M., Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)
Abstract: Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.
Published: 2011

45. Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Author: Nicolotti, Nicola, Chuang, S, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, C, Brenner, H, Hosono, S, La Vecchia, C, Talamini, R, Matsuo, K, Müller, H, Muscat, J, Paludetti, Gaetano, Ricciardi, Walter, Boffetta, P, Hashibe, M, Boccia, Stefania, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Nicolotti, Nicola, Chuang, S, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, C, Brenner, H, Hosono, S, La Vecchia, C, Talamini, R, Matsuo, K, Müller, H, Muscat, J, Paludetti, Gaetano, Ricciardi, Walter, Boffetta, P, Hashibe, M, Boccia, Stefania, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Paludetti, Gaetano (ORCID:0000-0003-2480-1243), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)
Abstract: Increasing evidence suggests that physical activity could prevent cancer, but scanty data is available on head and neck cancer (HNC). The aim of our study is to clarify the effect of recreational physical activity (rPA) on HNC. We analyzed data from four case-control studies, including 2,289 HNC cases and 5,580 controls. rPA was classified as: none/low (reference group), moderate and high. We calculated summary Odds Ratios (ORs) by pooling study-specific ORs. Overall, moderate rPA was associated with 22% lower risk of HNC compared to those with none or very low rPA levels [OR = 0.78, 95% Confidence Interval (95% CI): 0.66, 0.91]. Moderate rPA is associated with reduced risk of oral (OR = 0.74, 95% CI: 0.56, 0.97) and pharyngeal cancer (OR = 0.67, 95% CI: 0.53, 0.85), as well as high rPA levels (OR = 0.53, 95% CI: 0.32, 0.88 for oral cavity, OR = 0.58, 95% CI: 0.38, 0.89 for pharynx). High rPA levels, however, is associated with higher risk of laryngeal cancer (OR = 1.73, 95% CI: 1.04, 2.88). Stratified analyses showed that such inverse association between moderate rPA and HNC was more evident among males (OR = 0.75, 95% CI: 0.62, 0.90), subjects ≥45 years (OR = 0.78, 95% CI: 0.66, 0.93), and ever smokers and ever drinkers (OR = 0.72, 95% CI: 0.59, 0.88). High rPA significantly reduces HNC risk among subject ≥45 years (OR = 0.66, 95% CI: 0.48, 0.91). Promoting rPA might be inversely associated with HNC.
Published: 2011

46. First-principles study of potassium adsorption on TiO2 surfaces

Author: Muscat, J, Harrison, NM, and Thornton, G
Published: 1999

47. Effects of exchange, correlation, and numerical approximations on the computed properties of the rutile TiO2 (100) surface

Author: Muscat, J, Harrison, NM, and Thornton, G
Published: 1999

48. Previous Lung Diseases and Lung Cancer Risk: A Pooled Analysis From the International Lung Cancer Consortium

Author: Brenner, D. R., primary, Boffetta, P., additional, Duell, E. J., additional, Bickeboller, H., additional, Rosenberger, A., additional, McCormack, V., additional, Muscat, J. E., additional, Yang, P., additional, Wichmann, H.- E., additional, Brueske-Hohlfeld, I., additional, Schwartz, A. G., additional, Cote, M. L., additional, Tjonneland, A., additional, Friis, S., additional, Le Marchand, L., additional, Zhang, Z.-F., additional, Morgenstern, H., additional, Szeszenia-Dabrowska, N., additional, Lissowska, J., additional, Zaridze, D., additional, Rudnai, P., additional, Fabianova, E., additional, Foretova, L., additional, Janout, V., additional, Bencko, V., additional, Schejbalova, M., additional, Brennan, P., additional, Mates, I. N., additional, Lazarus, P., additional, Field, J. K., additional, Raji, O., additional, McLaughlin, J. R., additional, Liu, G., additional, Wiencke, J., additional, Neri, M., additional, Ugolini, D., additional, Andrew, A. S., additional, Lan, Q., additional, Hu, W., additional, Orlow, I., additional, Park, B. J., additional, and Hung, R. J., additional
Published: 2012
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49. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Author: Marron, M., primary, Boffetta, P., additional, Zhang, Z.-F., additional, Zaridze, D., additional, Wunsch-Filho, V., additional, Winn, D. M, additional, Wei, Q., additional, Talamini, R., additional, Szeszenia-Dabrowska, N., additional, Sturgis, E. M, additional, Smith, E., additional, Schwartz, S. M, additional, Rudnai, P., additional, Purdue, M. P, additional, Olshan, A. F, additional, Eluf-Neto, J., additional, Muscat, J., additional, Morgenstern, H., additional, Menezes, A., additional, McClean, M., additional, Matos, E., additional, Mates, I. N., additional, Lissowska, J., additional, Levi, F., additional, Lazarus, P., additional, Vecchia, C. L., additional, Koifman, S., additional, Kelsey, K., additional, Herrero, R., additional, Hayes, R. B, additional, Franceschi, S., additional, Fernandez, L., additional, Fabianova, E., additional, Daudt, A. W, additional, Maso, L. D., additional, Curado, M. P., additional, Cadoni, G., additional, Chen, C., additional, Castellsague, X., additional, Boccia, S., additional, Benhamou, S., additional, Ferro, G., additional, Berthiller, J., additional, Brennan, P., additional, Moller, H., additional, and Hashibe, M., additional
Published: 2009
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50. Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies

Author: Lubin, J. H., primary, Purdue, M., additional, Kelsey, K., additional, Zhang, Z.-F., additional, Winn, D., additional, Wei, Q., additional, Talamini, R., additional, Szeszenia-Dabrowska, N., additional, Sturgis, E. M., additional, Smith, E., additional, Shangina, O., additional, Schwartz, S. M., additional, Rudnai, P., additional, Neto, J. E., additional, Muscat, J., additional, Morgenstern, H., additional, Menezes, A., additional, Matos, E., additional, Mates, I. N., additional, Lissowska, J., additional, Levi, F., additional, Lazarus, P., additional, Vecchia, C. L., additional, Koifman, S., additional, Herrero, R., additional, Franceschi, S., additional, Wunsch-Filho, V., additional, Fernandez, L., additional, Fabianova, E., additional, Daudt, A. W., additional, Maso, L. D., additional, Curado, M. P., additional, Chen, C., additional, Castellsague, X., additional, Brennan, P., additional, Boffetta, P., additional, Hashibe, M., additional, and Hayes, R. B., additional
Published: 2009
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