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1. A case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus

Author

Hamada Kazu, Shimode Yuzo, Hata Yoshiyuki, Kunou Hiroaki, Kobayashi Rika, Matsunaga Kazuhiro, Kawaura Ken, Mukai Tsuyoshi, Kitakata Hidekazu, Itoh Tohru, Okuro Masashi, and Yamada Sohsuke

Subjects
biopsy, endoscopy, esophagus, hypopharynx, neurofibroma, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract A 50‐year‐old female was admitted to our hospital because of mild throat discomfort. Esophagogastroduodenoscopy demonstrated multiple 2–3 mm diameter whitish granules in her hypopharynx and cervical esophagus. Based on biopsy specimens, we considered the lesions to represent normal tissue or very mild mucosal dysplasia. However, S‐100 immunohistochemical staining 3 years later led to a diagnosis of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus. Histological finding characteristics of neurofibroma were present in 72.7% of hypopharyngeal biopsy specimens and 33.3% of esophageal specimens. When diagnosing neurofibroma, it is important to perform biopsies at multiple locations and at different times and to enlist the cooperation of endoscopists and pathologists for immunohistochemical staining with S‐100.

Published
2023
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2. WONDER-02: plastic stent vs. lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic pseudocysts—study protocol for a multicentre randomised non-inferiority trial

Author

Saito, Tomotaka, Takenaka, Mamoru, Kuwatani, Masaki, Doi, Shinpei, Ohyama, Hiroshi, Fujisawa, Toshio, Masuda, Atsuhiro, Iwashita, Takuji, Shiomi, Hideyuki, Hayashi, Nobuhiko, Iwata, Keisuke, Maruta, Akinori, Mukai, Tsuyoshi, Matsubara, Saburo, Hamada, Tsuyoshi, Inoue, Tadahisa, Matsumoto, Kazuyuki, Hirose, Sumio, Fujimori, Nao, Kashiwabara, Kosuke, Kamada, Hideki, Hashimoto, Shinichi, Shiratori, Toshiyasu, Yamada, Reiko, Kogure, Hirofumi, Nakahara, Kazunari, Ogura, Takeshi, Kitano, Masayuki, Yasuda, Ichiro, Isayama, Hiroyuki, and Nakai, Yousuke

Published
2024
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3. Artificial intelligence–based skeletal muscle estimates and outcomes of EUS-guided treatment of pancreatic fluid collections

Author

Sakai, Arata, Nakano, Ryota, Iwasa, Yuhei, Takenaka, Mamoru, Gonoi, Wataru, Sato, Tatsuya, Saito, Tomotaka, Hanaoka, Shouhei, Hamada, Tsuyoshi, Omoto, Shunsuke, Masuda, Atsuhiro, Tsujimae, Masahiro, Iwashita, Takuji, Uemura, Shinya, Ota, Shogo, Shiomi, Hideyuki, Fujisawa, Toshio, Takahashi, Sho, Matsubara, Saburo, Suda, Kentaro, Maruta, Akinori, Yoshida, Kensaku, Iwata, Keisuke, Okuno, Mitsuru, Hayashi, Nobuhiko, Mukai, Tsuyoshi, Isayama, Hiroyuki, Yasuda, Ichiro, and Nakai, Yousuke

Published
2024
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4. WONDER-01: immediate necrosectomy vs. drainage-oriented step-up approach after endoscopic ultrasound-guided drainage of walled-off necrosis—study protocol for a multicentre randomised controlled trial

Author

Sato, Tatsuya, Saito, Tomotaka, Takenaka, Mamoru, Iwashita, Takuji, Shiomi, Hideyuki, Fujisawa, Toshio, Hayashi, Nobuhiko, Iwata, Keisuke, Maruta, Akinori, Mukai, Tsuyoshi, Masuda, Atsuhiro, Matsubara, Saburo, Hamada, Tsuyoshi, Inoue, Tadahisa, Ohyama, Hiroshi, Kuwatani, Masaki, Kamada, Hideki, Hashimoto, Shinichi, Shiratori, Toshiyasu, Yamada, Reiko, Kogure, Hirofumi, Ogura, Takeshi, Nakahara, Kazunari, Doi, Shinpei, Chinen, Kenji, Isayama, Hiroyuki, Yasuda, Ichiro, and Nakai, Yousuke

Published
2023
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6. Risk of Pancreatitis Following Biliary Stenting With/Without Endoscopic Sphincterotomy: A Randomized Controlled Trial

Author

Kato, Shin, Kuwatani, Masaki, Onodera, Manabu, Kudo, Taiki, Sano, Itsuki, Katanuma, Akio, Uebayashi, Minoru, Eto, Kazunori, Fukasawa, Mitsuharu, Hashigo, Shunpei, Iwashita, Takuji, Yoshida, Makoto, Taya, Yoko, Kawakami, Hiroshi, Kato, Hironari, Nakai, Yousuke, Kobashigawa, Kasen, Kawahata, Shuhei, Shinoura, Susumu, Ito, Kei, Kubo, Kimitoshi, Yamato, Hiroaki, Hara, Kazuo, Maetani, Iruru, Mukai, Tsuyoshi, Shibukawa, Goro, and Itoi, Takao

Published
2022
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7. Possibility of Cell Block Specimens from Overnight-Stored Bile for Next-Generation Sequencing of Cholangiocarcinoma.

Author

Okuno, Mitsuru, Kanayama, Tomohiro, Iwata, Keisuke, Tanaka, Takuji, Tomita, Hiroyuki, Iwasa, Yuhei, Shirakami, Yohei, Watanabe, Naoki, Mukai, Tsuyoshi, Tomita, Eiichi, and Shimizu, Masahito

Subjects
NUCLEOTIDE sequencing, CHOLANGIOCARCINOMA, GENETIC variation, POSSIBILITY
Abstract

The identification of anticancer therapies using next-generation sequencing (NGS) is necessary for the treatment of cholangiocarcinoma. NGS can be easily performed when cell blocks (CB) are obtained from bile stored overnight. We compared NGS results of paired CB and surgically resected specimens (SRS) from the same cholangiocarcinoma cases. Of the prospectively collected 64 bile CBs from 2018 to 2023, NGS was performed for three cases of cholangiocarcinoma that could be compared with the SRS results. The median numbers of DNA and RNA reads were 95,077,806 [CB] vs. 93,161,788 [SRS] and 22,101,328 [CB] vs. 24,806,180 [SRS], respectively. We evaluated 588 genes and found that almost all genetic alterations were attributed to single-nucleotide variants, insertions/deletions, and multi-nucleotide variants. The coverage rate of variants in SRS by those found in CB was 97.9–99.2%, and the coverage rate of SRS genes by CB genes was 99.6–99.7%. The NGS results of CB fully covered the variants and genetic alterations observed in paired SRS samples. As bile CB is easy to prepare in general hospitals, our results suggest the potential use of bile CB as a novel method for NGS-based evaluation of cholangiocarcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Risk of recurrence with or without plastic stent after EUS-guided treatment of peripancreatic fluid collections: A systematic review and meta-analysis

Author

Iwashita, Takuji, primary, Sato, Tatsuya, primary, Yasuda, Ichiro, primary, Nakai, Yousuke, primary, Hamada, Tsuyoshi, additional, Saito, Tomotaka, additional, Iwata, Keisuke, additional, Shiomi, Hideyuki, additional, Takenaka, Mamoru, additional, Maruta, Akinori, additional, Uemura, Shinya, additional, Masuda, Atsuhiro, additional, Matsubara, Saburo, additional, Mukai, Tsuyoshi, additional, and Isayama, Hiroyuki, additional

Published
2023
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9. Peroral Pancreatoscopy-Guided Lithotripsy Compared with Extracorporeal Shock Wave Lithotripsy in the Management of Pancreatic Duct Stones in Chronic Pancreatitis: A Multicenter Retrospective Cohort Study.

Author

Iwata, Keisuke, Iwashita, Takuji, Mukai, Tsuyoshi, Iwasa, Yuhei, Okuno, Mitsuru, Yoshida, Kensaku, Maruta, Akinori, Uemura, Shinya, Yasuda, Ichiro, and Shimizu, Masahito

Subjects
EXTRACORPOREAL shock wave lithotripsy, PANCREATIC duct, CHRONIC pancreatitis, COHORT analysis
Abstract

Background: Extracorporeal shock wave lithotripsy (ESWL) is a common treatment for pancreatic stones in chronic pancreatitis. In contrast, peroral pancreatoscopy-guided lithotripsy (POPS-L) remains underexplored, with limited comparative studies to ESWL. This study compared the treatment outcomes of disposable POPS-L tools and ESWL for pancreatic stones. Methods: A retrospective analysis was conducted on 66 patients who had undergone pancreatic stone treatment at three institutions between 2006 and 2022. The treatment outcomes of POPS-L and ESWL were compared. Results: This study included 19 and 47 patients who had undergone POPS-L and ESWL, respectively. In a comparison between POPS-L and ESWL, the stone clearance rates were 78.9% vs. 70.2% (p = 0.55), while the procedure-related complication rates were 21% vs. 6.3% (p = 0.09). The median total session counts were 1 vs. 5 (p < 0.01). The cumulative stone recurrence rates were comparable in both groups. Multivariate analysis revealed no significant factors influencing the stone clearance rates, and the choice between POPS-L and ESWL did not affect the stone clearance rates. Conclusions: POPS-L and ESWL exhibited comparable treatment outcomes in terms of stone clearance, complications, and recurrence rates. Furthermore, POPS-L is advantageous due to the need for fewer sessions to achieve pancreatic stone clearance. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration.

Author

Okuno, Mitsuru, Iwata, Keisuke, Mukai, Tsuyoshi, Kito, Yusuke, Tanaka, Takuji, Watanabe, Naoki, Kasahara, Senji, Iwasa, Yuhei, Sugiyama, Akihiko, Nishigaki, Youichi, Shibata, Yuhei, Kitagawa, Junichi, Iwashita, Takuji, Tomita, Eiichi, and Shimizu, Masahito

Subjects
ENDOSCOPIC ultrasonography, NEEDLE biopsy, LYMPHADENITIS, LYMPHOMAS, DIAGNOSIS, NEEDLES & pins
Abstract

Background/Aims: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using a 19-gauge needle is an efficient sampling method for the diagnosis of lymphadenopathy. This study compared 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma (ML). Methods: Patient characteristics, number of needle passes, puncture route, sensitivity, specificity, and accuracy of cytology/histology for lymphadenopathy were analyzed in patients diagnosed with lymphadenopathy by EUS-FNA using conventional or Franseen needles. Results: Between 2012 and 2022, 146 patients met the inclusion criteria (conventional [n=70] and Franseen [n=76]). The median number of needle passes was significantly lower in the conventional group than in the Franseen group (3 [1-6] vs. 4 [1-6], p=0.023). There were no significant differences in cytological/histological diagnoses between the two groups. For ML, the immunohistochemical evaluation rate, sensitivity of flow cytometry, and cytogenetic assessment were not significantly different in either group. Bleeding as adverse events (AEs) were observed in three patients in the Franseen group. Conclusions: Both the 19-gauge conventional and Franseen needles showed high accuracy in lymphadenopathy and ML classification. Considering sufficient tissue collection and the avoidance of AEs, the use of 19-gauge conventional needles seems to be a good option for the diagnosis of lymphadenopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Comparison of 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma using endoscopic ultrasound fine-needle aspiration

Author

Okuno, Mitsuru, primary, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Kito, Yusuke, additional, Tanaka, Takuji, additional, Watanabe, Naoki, additional, Kasahara, Senji, additional, Iwasa, Yuhei, additional, Sugiyama, Akihiko, additional, Nishigaki, Youichi, additional, Shibata, Yuhei, additional, Kitagawa, Junichi, additional, Iwashita, Takuji, additional, Tomita, Eiichi, additional, and Shimizu, Masahito, additional

Published
2023
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15. Early versus delayed interventions for necrotizing pancreatitis: A systematic review and meta‐analysis

Author

Nakai, Yousuke, primary, Shiomi, Hideyuki, additional, Hamada, Tsuyoshi, additional, Ota, Shogo, additional, Takenaka, Mamoru, additional, Iwashita, Takuji, additional, Sato, Tatsuya, additional, Saito, Tomotaka, additional, Masuda, Atsuhiro, additional, Matsubara, Saburo, additional, Iwata, Keisuke, additional, Mukai, Tsuyoshi, additional, Isayama, Hiroyuki, additional, and Yasuda, Ichiro, additional

Published
2022
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19. Evaluation of the Cell Block Method Using Overnight-Stored Bile for Malignant Biliary Stricture Diagnosis

Author

Okuno, Mitsuru, primary, Mukai, Tsuyoshi, additional, Iwata, Keisuke, additional, Watanabe, Naoki, additional, Tanaka, Takuji, additional, Iwasa, Taisei, additional, Shimojo, Kota, additional, Ohashi, Yosuke, additional, Takagi, Akihiro, additional, Ito, Yuki, additional, Tezuka, Ryuichi, additional, Iwata, Shota, additional, Iwasa, Yuhei, additional, Kochi, Takahiro, additional, Ogiso, Tomio, additional, Hayashi, Hideki, additional, Sugiyama, Akihiko, additional, Nishigaki, Youichi, additional, and Tomita, Eiichi, additional

Published
2022
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20. Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report

Author

Miura, Seiko, primary, Niida, Yo, additional, Hashizume, Chieko, additional, Fujii, Ai, additional, Takagaki, Yuta, additional, Kusama, Kahoru, additional, Akazawa, Sumiyo, additional, Minami, Tetsuya, additional, Mukai, Tsuyoshi, additional, Furuichi, Kengo, additional, Tsuchishima, Mutsumi, additional, Ueda, Nobuhiko, additional, Takamura, Hiroyuki, additional, Koya, Daisuke, additional, and Ito, Tohru, additional

Published
2022
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21. Recent topics on endoscopic ultrasonography-guided celiac plexus neurolysis

Author

Araki Yasuhiro, Yasuda Ichiro, Mukai Tsuyoshi, Takahashi Kosuke, Iwata Keisuke, Iwashita Takuji, Doi Shinpei, and Hanaoka Tatsuyuki

Subjects
medicine.medical_specialty, lcsh:Internal medicine, lcsh:Specialties of internal medicine, Celiac Plexus Neurolysis, Celiac plexus, lcsh:Medicine, Endoscopic ultrasonography, lcsh:RC254-282, lcsh:RC581-951, Pancreatic cancer, Medicine, Radiology, Nuclear Medicine and imaging, lcsh:RC31-1245, Neurolysis, Hepatology, business.industry, lcsh:R, Gastroenterology, celiac plexus, endoscopic ultrasonography, neurolysis, pancreatic cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, digestive system diseases, medicine.anatomical_structure, Oncology, Radiology, business
Abstract

Endoscopic ultrasonography-guided celiac plexus neurolysis (EUS-CPN) is a widely practiced technique. Three sets of guidelines have recently been published and this procedure has become a major EUS technique. However, there are still several unanswered questions. The purpose of this manuscript is to review the recent literature pertaining to EUS-CPN. Currently, the main indication of EUS-CPN is pancreatic cancer pain. It is also performed for patients with chronic pancreatitis, but the indication is controversial due to its limited efficacy and a high incidence of infectious complications. Various techniques, such as central and bilateral EUS-CPN, and EUS-guided direct celiac ganglia neurolysis (EUS-CGN) have been performed. However, the efficacies of these techniques remain controversial. Complications related to the procedures are generally not serious, but major adverse events, such as paraplegia and ischemic complications, have been reported. The impacts of EUS-CPN on survival have also been evaluated. Although increased survival was expected via improvements in the quality of life, data suggests that EUS-CPN related procedures, especially EUS-CGN, might reduce the survival time. However, precise mechanisms have not been elucidated. In addition to conventional techniques, new techniques, such as EUS-guided celiac ganglion radiofrequency ablation (EUS-RFA) and the use of highly viscous phenol-glycerol, dexmedetomidine, and contrast-enhanced agents, have been introduced. However, these techniques are still in experimental stages. Additional studies need to be conducted to address these gaps in the literature.

Published
2020

23. Bleeding Risk Factors after Endoscopic Submucosal Dissection in Early Gastric Cancer and the Necessity of “Second-Look” Endoscopic Examination on the following Day

Author

Kobayashi, Rika, primary, Kawaura, Ken, additional, Ito, Tohru, additional, Azukisawa, Sadafumi, additional, Kunou, Hiroaki, additional, Kamai, Junji, additional, Hamada, Kazu, additional, Mukai, Tsuyoshi, additional, Kitakata, Hidekazu, additional, and Ishigaki, Yasuhito, additional

Published
2022
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28. Artificial intelligence–based skeletal muscle estimates and outcomes of EUS-guided treatment of pancreatic fluid collections

Author

Takenaka, Mamoru, Gonoi, Wataru, Sato, Tatsuya, Saito, Tomotaka, Hanaoka, Shouhei, Hamada, Tsuyoshi, Omoto, Shunsuke, Masuda, Atsuhiro, Tsujimae, Masahiro, Iwashita, Takuji, Uemura, Shinya, Ota, Shogo, Shiomi, Hideyuki, Fujisawa, Toshio, Takahashi, Sho, Matsubara, Saburo, Suda, Kentaro, Maruta, Akinori, Yoshida, Kensaku, Iwata, Keisuke, Okuno, Mitsuru, Hayashi, Nobuhiko, Mukai, Tsuyoshi, Isayama, Hiroyuki, Yasuda, Ichiro, Nakai, Yousuke, Sakai, Arata, Nakano, Ryota, and Iwasa, Yuhei

Abstract

Skeletal muscle status may affect clinical outcomes of a variety of pancreatic diseases. Skeletal muscle quality and quantity have not been fully examined in relation to the outcomes of EUS-guided treatment of pancreatic fluid collections (PFCs).

Published
2024
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29. Unilateral versus Bilateral Endoscopic Nasobiliary Drainage and Subsequent Metal Stent Placement for Unresectable Malignant Hilar Obstruction: A Multicenter Randomized Controlled Trial

Author

Hakuta, Ryunosuke, primary, Kogure, Hirofumi, additional, Nakai, Yousuke, additional, Kawakami, Hiroshi, additional, Maguchi, Hiroyuki, additional, Mukai, Tsuyoshi, additional, Iwashita, Takuji, additional, Saito, Tomotaka, additional, Togawa, Osamu, additional, Matsubara, Saburo, additional, Hayashi, Tsuyoshi, additional, Maetani, Iruru, additional, Ito, Yukiko, additional, Hasebe, Osamu, additional, Itoi, Takao, additional, Hanada, Keiji, additional, and Isayama, Hiroyuki, additional

Published
2021
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34. High and low negative pressure suction techniques in EUS- guided fine- needle tissue acquisition by using 25-gauge needles: a multicenter, prospective, randomized, controlled trial

Author

Kudo, Taiki, Kawakami, Hiroshi, Hayashi, Tsuyoshi, Yasuda, Ichiro, Mukai, Tsuyoshi, Inoue, Hiroyuki, Katanuma, Akio, Kawakubo, Kazumichi, Ishiwatari, Hirotoshi, Doi, Shinpei, Yamada, Reiko, Maguchi, Hiroyuki, Isayama, Hiroyuki, Mitsuhashi, Tomoko, and Sakamoto, Naoya

Abstract

Background: EUS-guided FNA (EUS-FNA) has a high diagnostic accuracy for pancreatic diseases. However, although most reports have typically focused on cytology, histological tissue quality has rarely been investigated. The effectiveness of EUS-FNA combined with high negative pressure (HNP) suction was recently indicated for tissue acquisition, but has not thus far been tested in a prospective, randomized clinical trial. Objective: To evaluate the adequacy of EUS-FNA with HNP for the histological diagnosis of pancreatic lesions by using 25-gauge needles. Design: Prospective, single-blind, randomized, controlled crossover trial. Setting: Seven tertiary referral centers. Patients: Patients referred for EUS-FNA of pancreatic solid lesions. From July 2011 to April 2012, 90 patients underwent EUS-FNA of pancreatic solid masses by using normal negative pressure (NNP) and HNP with 2 respective passes. The order of the passes was randomized, and the sample adequacy, quality, and histology were evaluated by a single expert pathologist. Intervention: EUS-FNA by using NNP and HNP. Main Outcome Measurements: The adequacy of tissue acquisition and the accuracy of histological diagnoses made by using the EUS-FNA technique with HNP. Results: We found that 72.2% (65/90) and 90% (81/90) of the specimens obtained using NNP and HNP, respectively, were adequate for histological diagnosis (P = .0003, McNemar test). For 73.3% (66/90) and 82.2% (74/90) of the specimens obtained by using NNP and HNP, respectively, an accurate diagnosis was achieved (P = .06, McNemar test). Pancreatitis developed in 1 patient after this procedure, which subsided with conservative therapy. Limitations: This was a single-blinded, crossover study. Conclusion: Biopsy procedures that combine the EUS-FNA with HNP techniques are superior to EUS-FNA with NNP procedures for tissue acquisition.

Published
2014

35. Radiotherapy for Gastric Bleeding from Tumor Invasion of Recurrent Colon Cancer with Liver Metastasis After Resection.

Author

Tanaka, Osamu, Yokoi, Ryoma, Mukai, Tsuyoshi, Yamada, Makoto, Kato, Tomohiro, Taniguchi, Takuya, Ono, Kousei, Matsuo, Masayuki, Department of Radiation Oncology, Murakami Memorial Hospital, Department of Surgery, Gifu Municipal Hospital, Department of Gastroenterology, Gifu Municipal Hospital, Department of Radiology, Gifu University School of Medicine, Tanaka, Osamu, Yokoi, Ryoma, Mukai, Tsuyoshi, Yamada, Makoto, Kato, Tomohiro, Taniguchi, Takuya, Ono, Kousei, Matsuo, Masayuki, Department of Radiation Oncology, Murakami Memorial Hospital, Department of Surgery, Gifu Municipal Hospital, Department of Gastroenterology, Gifu Municipal Hospital, and Department of Radiology, Gifu University School of Medicine

Abstract

source:https://link.springer.com/article/10.1007%2Fs12029-017-0026-7

Published
2018

36. Radiotherapy for Gastric Bleeding from Tumor Invasion of Recurrent Colon Cancer with Liver Metastasis After Resection

Author

Tanaka, Osamu, Yokoi, Ryoma, Mukai, Tsuyoshi, Yamada, Makoto, Kato, Tomohiro, Taniguchi, Takuya, Ono, Kousei, Matsuo, Masayuki, Department of Radiation Oncology, Murakami Memorial Hospital, Department of Surgery, Gifu Municipal Hospital, Department of Gastroenterology, Gifu Municipal Hospital, and Department of Radiology, Gifu University School of Medicine

Subjects
Oncology, Male, medicine.medical_specialty, Gastric bleeding, medicine.medical_treatment, Recurrent colon cancer, Resection, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Text mining, Stomach Neoplasms, Internal medicine, Medicine, Humans, Aged, business.industry, Liver Neoplasms, Gastroenterology, medicine.disease, Combined Modality Therapy, Radiation therapy, Sigmoid Neoplasms, 030220 oncology & carcinogenesis, Quality of Life, 030211 gastroenterology & hepatology, Dose Fractionation, Radiation, Neoplasm Recurrence, Local, business, Gastrointestinal Hemorrhage
Published
2017

41. Fracture system in the Kitazaki Tonalite at Tsuyazaki, Fukuoka Prefectute (Part 2)

Author

Yuhara, Masaki, Mitsui, Yohei, Uto, Chie, Kusamoto, Kazuyoshi, Sannodo, Nobuo, Mizoguchi, Tetsuyuki, Nakamura, Kazuki, Hira, Taisuke, Hayakawa, Naoki, Nakao, Chieko, Yamasaki, Noriko, Ono, Gosei, Nagamichi, Ryuji, Oda, Yayoi, Mukai, Tsuyoshi, Miyazaki, Hiroyuki, Nishi, Akina, Ejima, Mai, Furuno, Natsuko, Imafuku, Taro, Hisatsugu, Kensuke, Ishihara, Yoshiro, Aizawa, Jun, and Sugiyama, Tetsuro

Published
2004

42. A multicenter, prospective, randomized study of selective bile duct cannulation performed by multiple endoscopists: the BIDMEN study

Author

Kawakami, Hiroshi, Maguchi, Hiroyuki, Mukai, Tsuyoshi, Hayashi, Tsuyoshi, Sasaki, Tamito, Isayama, Hiroyuki, Nakai, Yousuke, Yasuda, Ichiro, Irisawa, Atsushi, Niido, Teitetsu, Okabe, Yoshinobu, Ryozawa, Shomei, Itoi, Takao, Hanada, Keiji, Kikuyama, Masataka, Arisaka, Yoshifumi, Kikuchi, Shogo, Kawakami, Hiroshi, Maguchi, Hiroyuki, Mukai, Tsuyoshi, Hayashi, Tsuyoshi, Sasaki, Tamito, Isayama, Hiroyuki, Nakai, Yousuke, Yasuda, Ichiro, Irisawa, Atsushi, Niido, Teitetsu, Okabe, Yoshinobu, Ryozawa, Shomei, Itoi, Takao, Hanada, Keiji, Kikuyama, Masataka, Arisaka, Yoshifumi, and Kikuchi, Shogo

Abstract

Background: Wire-guided cannulation (WGC) with a sphincterotome for selective bile duct cannulation (SBDC) has been reported to have a higher success rate and lower incidence of post-ERCP pancreatitis (PEP) than conventional methods in some randomized controlled trials (RCTs) that were both single-center and limited to only a few endoscopists. Objective: To estimate the difference in SBDC according to the method and catheter used in a multicenter and multi-endoscopist study. Design: A prospective multicenter RCT with a 2-by-2 factorial design. Setting: Fifteen referral endoscopy units. Patients: In total, 400 consecutive patients with naïve papilla who were candidates for ERCP were enrolled and randomized. Interventions: Patients were assigned to 4 groups according to combined catheter (sphincterotome (S) or catheter (C)) and method (with/without guidewire (GW)). Main Outcome Measurements: Success rate of SBDC in 10 min, time for SBDC, fluoroscopic time and incidence of complications. Results: There was no significant difference in SBDC success rate between with- and without-GW, between C and S, or between the 4 groups (C+GW, C, S+GW, S). WGC had a tendency to significantly shorten cannulation and fluoroscopy times only in approximately 70% of patients in this study in whom SBDC was achieved in 10 min or less (P = 0.036 and 0.00004, respectively). All 4 groups resulted in similar outcomes in PEP (4%, 5.9%, 2%, and 2.1%, respectively). Limitations: Non double-blind study. Conclusions: WGC appears to significantly shorten cannulation and fluoroscopic times. However, neither the method nor type of catheter used resulted in significant differences in either SBDC success rate or incidence of PEP in this RCT.

Published
2012

43. A multicenter, prospective, randomized study of selective bile duct cannulation performed by multiple endoscopists: the BIDMEN study

Author

1000080399823, Kawakami, Hiroshi, Maguchi, Hiroyuki, Mukai, Tsuyoshi, Hayashi, Tsuyoshi, Sasaki, Tamito, Isayama, Hiroyuki, Nakai, Yousuke, Yasuda, Ichiro, Irisawa, Atsushi, Niido, Teitetsu, Okabe, Yoshinobu, Ryozawa, Shomei, Itoi, Takao, Hanada, Keiji, Kikuyama, Masataka, Arisaka, Yoshifumi, Kikuchi, Shogo, 1000080399823, Kawakami, Hiroshi, Maguchi, Hiroyuki, Mukai, Tsuyoshi, Hayashi, Tsuyoshi, Sasaki, Tamito, Isayama, Hiroyuki, Nakai, Yousuke, Yasuda, Ichiro, Irisawa, Atsushi, Niido, Teitetsu, Okabe, Yoshinobu, Ryozawa, Shomei, Itoi, Takao, Hanada, Keiji, Kikuyama, Masataka, Arisaka, Yoshifumi, and Kikuchi, Shogo

Abstract

Background: Wire-guided cannulation (WGC) with a sphincterotome for selective bile duct cannulation (SBDC) has been reported to have a higher success rate and lower incidence of post-ERCP pancreatitis (PEP) than conventional methods in some randomized controlled trials (RCTs) that were both single-center and limited to only a few endoscopists. Objective: To estimate the difference in SBDC according to the method and catheter used in a multicenter and multi-endoscopist study. Design: A prospective multicenter RCT with a 2-by-2 factorial design. Setting: Fifteen referral endoscopy units. Patients: In total, 400 consecutive patients with naïve papilla who were candidates for ERCP were enrolled and randomized. Interventions: Patients were assigned to 4 groups according to combined catheter (sphincterotome (S) or catheter (C)) and method (with/without guidewire (GW)). Main Outcome Measurements: Success rate of SBDC in 10 min, time for SBDC, fluoroscopic time and incidence of complications. Results: There was no significant difference in SBDC success rate between with- and without-GW, between C and S, or between the 4 groups (C+GW, C, S+GW, S). WGC had a tendency to significantly shorten cannulation and fluoroscopy times only in approximately 70% of patients in this study in whom SBDC was achieved in 10 min or less (P = 0.036 and 0.00004, respectively). All 4 groups resulted in similar outcomes in PEP (4%, 5.9%, 2%, and 2.1%, respectively). Limitations: Non double-blind study. Conclusions: WGC appears to significantly shorten cannulation and fluoroscopic times. However, neither the method nor type of catheter used resulted in significant differences in either SBDC success rate or incidence of PEP in this RCT.

Published
2012

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