Search

Your search keyword '"Muhammad Hammad Ur Rehman"' showing total 2 results
Start Over Author "Muhammad Hammad Ur Rehman" Search Limiters Available in Library Collection
2 results on '"Muhammad Hammad Ur Rehman"'

1. Initial Experience of Pancreaticoduodenectomy in a Newly Developed Hepato-pancreato-Biliary Unit Serving in a Lower-Middle Income Country

Author

Neelma, Azwa Rashid, Muhammad Waqas, Muhammad Hammad Ur Rehman, Asad Ullah Khan, and Syed Irfan Kabir

Subjects
Pancreaticoduodenectomy, preoperative biliary drainage, postoperative pancreatic fistula, total laparoscopic pancreaticoduodenectomy, Whipple’s procedure, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: Pancreaticoduodenectomy (PD) is the only potentially curative treatment for pancreatic head adenocarcinoma. This study aimed to determine short-term outcomes of PD performed over one year at a newly established Hepato-Pancreatico-Biliary (HPB) unit in Khyber Pakhtun Khwa (KPK) Province of Pakistan. Material and methods: A retrospective analysis of a prospectively maintained Hospital Information System (HIS) was undertaken of all patients referred to the unit between May 2021 to August 2022. Data were collected from the medical records of patients in the hospital information system. Data were analyzed for primary location, age, complications, and operative parameters. Results: The primary site of disease were ampulla (n=18, 52.9%), pancreas (n=11, 32.4%), and duodenum (n=5, 14.7%). The median duration of surgery was 7 hours. 16 (47.1%) patients required blood transfusion either intraoperatively or in the peri-operative period. Patients with preoperative biliary drainage (PBD) were more likely to have multidrug-resistant positive bile cultures with a p-value of 0.2 [n=12(35.3%) vs n=5(14.7%)]. Overall morbidity was 38.2%. The most common complications were wound infection (n=12, 35.3%), delayed gastric emptying (n=6, 17.6%), and type B pancreatic fistula (n=3, 8.8%). The complication rate was higher in patients with biliary stenting [n=11(32.4%) vs n=2 (5.9%); p-value 0.06]. The median length of hospital stay for patients without complications was less (6 vs 12 days; P

Published
2024
Full Text
View/download PDF

2. Translocation t(1;19) in acute precursor B-cell lymphoblastic Leukaemia in paediatric patients- Pakistani population

Author

Palwasha Rehman, null Romena Qazi, and null Muhammad Hammad-ur-Rehman

Subjects
Male, Chromosome Aberrations, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Acute Disease, Humans, Female, Pakistan, General Medicine, Neoplasm Recurrence, Local, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Translocation, Genetic, Retrospective Studies
Abstract

Objective: To determine the impact of translocation t(1;19) in paediatric patients diagnosed with precursor B-cell acute lymphoblastic leukaemia. Methods: The retrospective study was conducted at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised data from January 2012 to January 2018 of paediatric patients diagnosed with precursor B-cell acute lymphoblastic leukaemia. Data of patients having t(1;19) translocation with or without complex karyotype formed group A, while data of patients without any cytogenetic abnormality formed the control group B. Relapse and event-free survival were calculated and the outcomes were compared between the groups. Data was analysed using SPSS 20. Results: Of the 450 subjects whose data was analysed, 84(18.7%) were included; 25(30%) in group A and 59(70%) were in group B. There were 21(84%) males and 4(16%) females in group A with mean age on presentation 3.68±0.6 years compared to 41(69.4%) males and 18(30.5%) females with mean age on presentation 4.0±0.92 (p>0.05). There were no differences between the groups in terms of baseline markers (p>0.05). The relapse and event-free survival rates were also not significantly different between the groups (p>0.05). Conclusion: There was no significant difference related to outcomes of precursor B-cell acute lymphoblastic leukaemia patients having t(1;19) translocation with or without complex karyotype and those without any cytogenetic abnormality, indicating that translocation t(1;19)-positive patients do not need treatment intensification. Key Words: Acute Pre-B ALL, Children, t (1;19), Oncoprotein E2A-PBX1.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results