237 results on '"Motwani M"'
Search Results
2. A Novel Procedure for Keratoconus/Corneal Ectasia Treating Epithelial Compensation of Higher-Order Aberrations, Topographic Guided Ablation, and Corneal Cross Linking – The CREATE+CXL Protocol
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Motwani M
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astigmatism ,corneal cross linking ,higher-order aberrations ,keratoconus ,lower-order aberrations ,photorefractive keratectomy ,corneal ectasia ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Cornea Revolution/Motwani LASIK Institute, San Diego, CA, 92121, USACorrespondence: Manoj Motwani, Cornea Revolution/Motwani LASIK Institute, 8710 Scranton Road, Ste 170, San Diego, CA, 92121, USA, Tel +1 858 554-0008, Email drmmlj@gmail.comPurpose: To present the outcomes of a retrospective study in keratoconus/corneal ectasia patients of treating the higher order aberrations compensated for the corneal epithelium in addition to topographic guided ablation followed by corneal cross linking.Methods: Twenty-seven eyes of 14 patients were treated for keratoconus/corneal ectasia utilizing trans-epithelial topographic guided ablation photorefractive keratectomy (PRK) for treatment of corneal higher order aberrations and lower order astigmatism followed immediately by 15-minute cross linking were examined retrospectively. Six-month results were analyzed via measurement of vision, refraction, residual higher-order aberrations (HOAs), residual lower-order and higher-order aberrations, as well as for loss or gains of lines of best corrected visual acuity.Results: All eyes save one had reduction in K1, K2, K Max, and K Mean. All eyes had reduction in manifest astigmatism, Contoura measured astigmatism, 57% reduction of higher-order aberrations (HOA), and 53% reduction of higher-order aberrations grouped with lower-order aberrations (Grouped). Nearly all (96.3%) eyes achieved 20/40 vision or better, 20 eyes had 1– 7 lines gained of vision, and no eyes had any loss of lines of vision.Conclusion: Use of the CREATE+CXL protocol combined with 15-minute corneal cross linking results in a significant increase in HOA reduction, as well as a significant improvement in corrected distance visual acuity over past procedures.Keywords: astigmatism, corneal cross linking, higher-order aberrations, keratoconus, lower-order aberrations, photorefractive keratectomy, corneal ectasia
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- 2023
3. Understanding Variable Biologic-Based Factors in Determining Laser Refractive Surgery Outcomes: A Response to the Moshirfar et al Paper [Letter]
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Motwani M
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Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Cornea Revolution/Motwani LASIK Institute, San Diego, CA, 92121, USACorrespondence: Manoj Motwani, Cornea Revolution/Motwani LASIK Institute, 9710 Scranton Road, Suite 170, San Diego, CA, 92121, USA, Tel +1 858 554-0008, Email drmmlj@gmail.com
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- 2023
4. Treatment of Corneal Irregularity in Radial/Astigmatic Keratotomy Patients Utilizing WaveLight Contoura
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Motwani M
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wavelight contoura ,topographic guided ablation ,lasik ,prk ,uniform cornea ,measured astigmatism ,radial keratotomy ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr., Suite 230, San Diego, CA, 92121, USATel +1 858 554-0008Email drmmlj@gmail.comPurpose: To demonstrate the treatment of radial keratotomy-induced corneal irregularity with topographic-guided ablation (WaveLight Contoura).Methods: Thirty-two eyes of 18 patients were treated for corneal irregularity post-radial keratotomy with WaveLight Contoura topographic-guided ablation utilizing LASIK and PRK and the San Diego Protocol for reconstructing corneas. These eyes were followed for six-months. Outcomes included: measurements of vision, refraction, residual higher-order aberrations, residual lower-order and higher-order aberrations, as well as loss or gains of lines of best-corrected visual acuity.Results: All eyes had decreased corneal irregularity as evidenced by topographic analysis and reduction in manifest astigmatism, Contoura-measured astigmatism, higher-order aberrations, and higher-order aberrations grouped with lower-order aberrations excluding tilt (Grouped). The eyes of 5 sample patients are included in this manuscript to demonstrate the procedure, protocol, and outcomes.Conclusion: Treatment with WaveLight Contoura whether as LASIK or PRK appears to be an effective treatment for corneal irregularity associated with radial/astigmatic keratotomy.Keywords: WaveLight Contoura, topographic-guided ablation, LASIK, PRK, uniform cornea, measured astigmatism, radial keratotomy
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- 2022
5. Treatment of Keratoconus with WaveLight Contoura and Corneal Cross-Linking Combined
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Motwani M
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astigmatism ,best-corrected visual acuity ,corneal cross-linking ,higher-order aberrations ,keratoconus ,topographic guided ablation ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr., Suite 230, San Diego, CA, 92121, USATel +1 858 554-0008Email drmmlj@gmail.comPurpose: To investigate the outcomes of the treatment of keratoconus/corneal ectasia utilizing topographic-guided ablation (WaveLight Contoura) followed by corneal cross-linking.Methods: Thirty-six eyes of 21 patients were treated for keratoconus/corneal ectasia utilizing topographic guided ablation photorefractive keratectomy (PRK) for treatment of corneal higher-order aberrations and refractive error followed immediately by 15-minute cross-linking were examined retrospectively. Six-month results were analyzed via measurement of vision, refraction, residual higher-order aberrations (HOAs), residual lower-order and higher-order aberrations, as well as for loss or gains of lines of best-corrected visual acuity.Results: All eyes save one had reduction in K1, K2, K Max, K Mean. All eyes had reduction in manifest astigmatism, Contoura-measured astigmatism, higher-order aberrations, higher-order aberrations grouped with lower-order aberrations (Grouped). Four eyes had lost 1– 2 lines of vision, mainly to corneal haze formation, 17 eyes gained lines of vision, and 15 eyes equaled their pre-op best-corrected visual acuity. Eight eyes from four sample patients have their data included in this manuscript to demonstrate the procedure and the outcomes.Conclusion: Treatment with WaveLight Contoura combined with 15-minute corneal cross-linking is an effective and safe treatment for keratoconus and should be considered a primary treatment to prevent corneal transplant as well as improve vision and corneal irregularity.Keywords: astigmatism, best-corrected visual acuity, corneal cross-linking, higher-order aberrations, keratoconus, topographic-guided ablation
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- 2021
6. Analysis and Causation of All Inaccurate Outcomes After WaveLight Contoura LASIK with LYRA Protocol
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Motwani M
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astigmatism ,corneal epithelium ,femtosecond laser ,higher-order aberration ,lasik ,refractive error ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr., Suite 230, San Diego, CA 92121, USATel +1 (858) 554-0008Email drmmlj@gmail.comPurpose: This study analyzes every eye that had an outcome greater than 0.25D of sphere or astigmatism from planned goal after treatment with WaveLight Contoura with LYRA Protocol.Methods: The study included 266 consecutive eyes treated with LASIK Contoura using the LYRA Protocol. All LASIK procedures were performed on the WaveLight EX500 excimer laser. Flaps were created with either the Alcon WaveLight FS200 femtosecond laser or the Moria M2 microkeratome. Eyes that were off by > 0.25 diopters (D) sphere or cylinder from the targeted goal within 3 months after surgery were identified and analyzed for cause. Topographical, higher-order aberration, and epithelial maps were created.Results: Causes for inaccurate outcomes were biomechanical corneal change from LASK flap creation (9.78% of total eyes), pre-operative epithelial compensation of corneal higher-order aberration (4.1% of total eyes), changes to lamellar corneal tension from laser ablation causing a hyperopic shift (1.9% of total eyes), epithelial thickening over the ablation area post-operatively causing a refractive change (1.5% of total eyes), and posterior astigmatism (0.75%).Conclusion: The causes of the majority of inaccurate outcomes have not been properly defined and must be incorporated into further improving outcomes. Current and planned advances in technology do not address the majority of these causes.Keywords: astigmatism, corneal epithelium, femtosecond laser, higher-order aberration, LASIK, refractive error; Contoura; topography guided ablation; LYRA protocol
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- 2020
7. Predictions of Residual Astigmatism from Surgical Planning for Topographic-Guided LASIK Based on Anterior Corneal Astigmatism (LYRA Protocol) vs the Phorcides Analytic Engine
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Motwani M
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contoura ,topographic guided ablation ,lyra protocol ,phorcides ,uniform cornea ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr, Suite 230, San Diego, CA 92121, USATel +1 (858) 554-0008Email drmmlj@gmail.comPurpose: To identify the laser programming strategy that achieves the highest refractive astigmatism outcomes accuracy between LYRA surgical planning and Phorcides surgical planning.Methods: One hundred one eyes successfully treated with Contoura with LYRA Protocol were retrospectively surgically planned with Phorcides to determine its accuracy. Eighteen eyes that had inaccurate 3 month outcomes with LYRA were also retrospectively planned with Phorcides. Two patients with one eye treated with LYRA and one with Phorcides surgical planning were analyzed for outcomes.Results: Retrospective Phorcides surgical planning deviated from already successful treatments with LYRA Protocol 51% of the time, with an average astigmatic deviation of 0.69 diopters (D) and an average deviation of 7.1 degrees. The percentage of eyes of the 101 successfully treated with LYRA Protocol then planned with Phorcides differed by 0.5D in 19.8%, by 0.75D in 23.8%, and by 1D in 7.9%. A retrospective analysis with Phorcides of patients treated with LYRA Protocol with residual post-operative astigmatism demonstrated that Phorcides would have increased accuracy in only 33% of patients, and not helped or decreased accuracy in the rest.Conclusion: Phorcides was significantly less accurate in surgical planning than the LYRA Protocol overall and a 51% of primary patients could have a likelihood of significant residual astigmatism. Phorcides would also have provided a less accurate outcome in the majority of patients that needed secondary enhancement.Keywords: Contoura, topographic-guided ablation, LYRA Protocol, Phorcides, uniform cornea
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- 2020
8. Biomechanical Changes to the Cornea from LASIK Flap Creation Resulting in Inaccurate Ablations and Suboptimal Refractive Outcomes with Topographic-Guided Ablation
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Motwani M
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corneal epithelium ,femtosecond laser ,higher order aberration ,laser ablation ,laser in-situ keratomileusis ,lasik ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr., Suite 230, San Diego, CA 92121, USATel +1 858 554-0008Email drmmlj@gmail.comPurpose: This study documents a biomechanical corneal change related to corneal flap creation in certain patients leading to an irregular ablation pattern and an inaccurate refractive outcome.Methods: This retrospective study included consecutive eyes treated with primary LASIK Contoura using the LYRA Protocol. All LASIK procedures were performed on the WaveLight EX500 excimer laser. Flaps were created with either the Alcon WaveLight FS200 femtosecond laser or the Moria M2 microkeratome. Eyes that were off by greater than or equal to 0.50 diopters (D) sphere or cylinder from the targeted goal within 3 months after surgery were identified. Topographical, higher order aberration, and epithelial maps were created. Of these eyes, approximately 10% of eyes were found to have undergone a biomechanical change upon flap creation that led to an inaccurate outcome.Results: Six representative cases are presented that demonstrate the biomechanical change, outcomes, and treatment. All patients demonstrated an elliptical, irregular ablation pattern on post-operative topography, lateralized the thinnest point of the cornea relative to the corneal apex on Pentacam pachymetry maps, and irregular corneal epithelial thickening at the periphery of the elliptical ablation.Conclusion: A biomechanical change during flap creation can occur in certain types of corneas during LASIK flap creation and subsequent treatment with topographic-guided ablation leading to an irregular ablation and suboptimal refractive outcomes.Keywords: corneal epithelium, femtosecond laser, higher order aberration, laser ablation, laser in-situ keratomileusis, LASIK
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- 2020
9. Clinical Outcomes After Topography-guided Refractive Surgery in Eyes with Myopia and Astigmatism—Comparing Results with New Planning Software to Those Obtained Using the Manifest Refraction [Letter]
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Motwani M
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lasik ,myopia ,astigmatism ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr., Suite 230, San Diego, CA, 92121, USATel +1 858 554-0008Email drmmlj@gmail.com In response to the study performed by Brunson et al “Clinical Outcomes After Topography-guided Refractive Surgery in Eyes with Myopia and Astigmatism—Comparing Results with New Planning Software to Those Obtained Using the Manifest Refraction,” there are significant issues with this study and the use of the Phorcides Analytic Engine that must be examined. 1Both manuscripts now published concerning outcomes from the PAE have essentially followed the same script—focus on comparison to manifest refraction, comparing only visual results, no mention of axis variance from either manifest or Contoura measured astigmatism, no mention of controls in picking patients for inclusion in the study, such as a consecutive series to prevent “cherry-picking,” small deviations in between magnitudes of manifest, Contoura measured, and Phorcides astigmatism, no topographic analysis to demonstrate that a more uniform cornea was being created, no analysis of Zernicke higher order aberration polynomials to show that HOAs were reduced and not induced, no data concerning residual astigmatism after treatment (except for a line stating no patient had greater than 0.5 D of residual astigmatism), no subjective patient outcomes, and no scientific explanation as to why Phorcides should be used and not simply the Contoura measured astigmatism, which also analyses the higher order aberrations on the anterior corneal surface, which is the most important refracting element of any optical system. 1,2View the original paper by Brunson and colleagues A Response to Letter has been published for this article.
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- 2021
10. Response to the Correct Usage of the Term “off-Label” in the Context of Corneal Cross-Linking [Response To Letter]
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Motwani M
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Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, 92121, USACorrespondence: Manoj MotwaniMotwani LASIK Institute, 4520 Executive Dr., Suite 230, San Diego, CA, 92121, USATel +1 858 554-0008Email drmmlj@gmail.com View the original paper by Dr Motwani and colleagues This in response to the Letters to the Editor L Jay Katz Neda Shamie
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- 2021
11. Response to: WaveLight® Contoura topography-guided planning: contribution of anterior corneal higher-order aberrations and posterior corneal astigmatism to manifest refractive astigmatism
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Motwani M
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Topographic guided ablation ,LYRA Protocol ,Contoura ,Posterior Corneal Astigmatism ,Lenticular Astigmatism. ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani Lasik Institute, San Diego, CA, USA I would like to thank Wallerstein et al1 for his thoughtful research letter, but I do have some issue with the analysis. The paper references only Part 1 of the LYRA Protocol series, and not the other two parts. Part 3 provides the data for treatment with Contoura-measured astigmatism using the LYRA Protocol (termed anterior corneal astigmatism [ACA]). The concept of anterior corneal higher-order aberrations (CHOA) modifying the manifest refractive astigmatism (RA) was illustrated in an ovalization form to demonstrate why the LYRA Protocol works. These interactions are three-dimensional (3D) in nature, and we are demonstrating with 2D CHOA maps from Contoura. These maps are impacted by user/technical error, and also by epithe¬lial compensation of the CHOA, adding a layer of inaccuracy in these comparisons. In fact, the concept of epithelial compensation affecting the ability to measure and treat CHOA is not part of any current refractive system, Contoura, Ray tracing, etc. The static Gullstrand model has mainly been used, ignoring the fact that epithelial compensation causes variability. View the original paper by Wallerstein and colleagues.
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- 2018
12. The use of WaveLight Contoura to create a uniform cornea: 6-month results with subjective patient surveys
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Motwani M and Pei R
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Astigmatism ,WaveLight Contoura ,topographic guided ablation ,LASIK ,cornea ,Contoura with LYRA Protocol ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani,1 Ronald Pei2 1LASIK Institute, San Diego, CA, USA; 2Precision Outcome Consultants, Fresno, CA, USA Purpose: The aim of this study was to report on the 6-month visual results of Contoura with Layer Yolked Reduction of Astigmatism (LYRA) protocol, as well as the subjective patient-reported outcomes (PRO) by standardized survey. Patients and methods: A retrospective analysis was conducted in 50 consecutive eyes with 6-month results that had bilateral Contoura laser-assisted in situ keratomileusis (LASIK) correction of measured astigmatism and axis using the LYRA protocol. PRO were measured via the Refractive Status and Vision Profile (RSVP) standardized survey. Objective visual results, subjective patient results, and rates of regression were reported. Results: Most (78%) of the eyes achieved an uncorrected visual acuity (UCVA) of 20/15 and 98% of the eyes achieved an UCVA of 20/20 vision after primary correction. After enhancements, the percentage of uncorrected eyes achieving 20/15 vision was 90 and 20/20 vision was 100. RSVP patient-related outcomes showed that all patients (100%) were either satisfied or very satisfied with their vision. Most patients (21/25, 84%) were very satisfied. On a numerical ordinal scale of 1–10 (where 10 is the best vision), as reported by patients post-operative (post-op), 15 (60%) patients reported a vision score of 10, nine (36%) patients reported a score of 9, and one (4%) patient reported a score of 8. Initial correction was accurate on all patients, but nine eyes had refractive error changes due to epithelial masking of higher order aberrations (HOAs) over the follow-up period, a number that was also likely artificially high due to study bias. Conclusion: Contoura measured axis and astigmatism-eliminated HOA, resulting in a more uniform cornea with an accurate removal of astigmatism, excellent 20/15 and 20/20 visual outcomes, and favorable patient-reported subjective outcomes. Keywords: astigmatism, WaveLight Contoura, topography-guided ablation, LASIK, cornea, Contoura with LYRA protocol
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- 2018
13. Topographic-guided treatment of hyperopic corrections with a combination of higher order aberration removal with WaveLight® Contoura and wavefront-optimized hyperopic treatment
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Motwani M
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astigmatism ,excimer laser ,high-order aberration ,hyperopia ,laser-assisted in situ keratomileusis ,LASIK ,regression ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani Lasik Institute, San Diego, CA, USA Purpose: This pilot study was conducted to test the hypothesis that WaveLight® Contoura and wavefront-optimized (WFO) hyperopic treatment can be used together for hyperopia/hyperopic astigmatism to create more uniform corneas. Materials and methods: A retrospective analysis was conducted in 35 consecutive hyperopic/hyperopic astigmatism eyes of 22 patients treated via LASIK on the Wavelight® EX500. Higher order aberrations and astigmatism were removed using Contoura with the Layer Yolked Reduction of Astigmatism (LYRA) Protocol, and hyperopia was treated with WFO correction. All patients had 3 months of follow-up. Outcome measures were assessed by post-operative refraction, regression, and post-operative vision. Topographic analysis showed the degree of uniformity of the cornea achieved. Results: Average hyperopia treated was +2 diopters (D) (range +0.50 D to +7.25 D), with the average amount of astigmatism treated +1.05 D (range -0.25 D to -2.25 D). The average difference between the Contoura-measured and manifest magnitude of astigmatism was 0.674 D and the average axis difference was 5.65°. No eyes lost corrected distance visual acuity (CDVA), 22.8% of eyes gained CDVA. At 3 months, 18 (54%) eyes had regressed or not achieved their targeted goal, and the average spherical equivalent (SE) from the targeted goal was 0.973 D. Following primary procedure, 10 of these eyes had myopic SE, six had hyperopic SE, and two had SE of 0. Prior to surgery, 19 of 24 distance eyes were able to achieve 20/20 vision, and if secondary corrections are included 100% achieved 20/20 or better post-operative, and eight (42%) achieved 20/15 or better at 3 months post-operative. No eyes lost CDVA. Conclusion: This pilot study demonstrated that more uniform corneas can be created while treating hyperopic corrections, but a high level of secondary corrections were needed. Keywords: Contoura, topographic guided ablation, hyperopia, LYRA Protocol
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- 2018
14. Treatment of high myopia/myopic astigmatism with a combination of WaveLight Contoura with LYRA protocol and wavefront-optimized treatment
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Motwani M
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corneal ablation ,topographic guided ablation ,laser-assisted in situ keratomileusis ,photorefractive keratectomy ,WaveLight Contoura ,myopia ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, USA Purpose: The aim of this article was to demonstrate how WaveLight Contoura and wavefront optimization (WFO) can be used together to treat high myopia/myopic astigmatism corrections. Materials and methods: A retrospective analysis was conducted on 24 consecutive myopic/myopic astigmatism eyes that exceeded the Contoura labeling of -8.00 with -3.00 D of astigmatism. Residual correction after Contoura with Layer Yolked Reduction of Astigmatism protocol was treated with WFO Contoura LASIK correction. All patients had 3 months of follow-up. Accuracy to the desired refractive goal was assessed by postoperative refraction, regression, postoperative vision, and anecdotal subjective night vision quality. Results: No eyes lost best-corrected visual acuity (BCVA), and 54% of eyes gained BCVA. Out of 22 distance eyes, five achieved 20/15 or better, 18 achieved 20/20 vision, two achieved 20/25, and three achieved 20/30 vision. Preoperatively, only 14 eyes could achieve 20/20 vision. No night vision issues were observed in anecdotal reporting by patients except for those who needed enhancements that had not yet been performed. Conclusion: Treatment of high myopia/astigmatism with this combination of Contoura with LYRA protocol and WFO results in excellent visual outcomes, large ablation zones on topography, and few subjective reported night vision issues. Keywords: Contoura, topographic guided ablation, high myopia, ICL, WaveLight lasers, LYRA Protocol
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- 2018
15. Treatment of moderate-to-high hyperopia with the WaveLight Allegretto 400 and EX500 excimer laser systems
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Motwani M and Pei R
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Excimer laser ,hyperopia ,laser-assisted in situ keratomileusis ,LASIK ,regression ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani,1 Ronald Pei1,21Motwani LASIK Institute, San Diego, 2Precision Outcome Consultants, Fresno, CA, USAPurpose: To evaluate the efficacy of treating patients with +3.00 diopters (D) to +6.00 D of hyperopia via laser-assisted in situ keratomileusis (LASIK) with the WaveLight Allegretto 400 and EX500 excimer laser systems.Setting: Private clinical ophthalmology practice.Patients and methods: This was a retrospective study of patients undergoing LASIK treatments of +3.00 to +6.00 D on two different WaveLight laser systems: 163 eyes on the 400 (Hertz) Hz system and 54 eyes on the 500 Hz system. The duration of follow-up was 6 months postoperation. Data were evaluated for uncorrected distance visual acuity, corrected distance visual acuity (CDVA), spherical equivalents (SEQs), and changes in these parameters (eg, loss of vision, regression over time).Results: Treatment with both lasers was safe and effective, with loss of one line of CDVA in four of 162 eyes using the 400 Hz laser system, and none of the 54 eyes with the 500 Hz laser system. Overall, regression ≥0.75 D from goal at 6 months was observed in 11.7% (19/163) of eyes in the 400 Hz laser group and 9.26% (5/54) of eyes in the 500 Hz laser group (regression ≥0.50 D =77.9% [127/163] and 77.8% [42/54], respectively). The mean SEQ regressions for all eyes with moderate hyperopia were 0.10 and 0.18 D for those with high hyperopia.Conclusions: Both the 400 and 500 Hz excimer laser systems were safe and effective for the LASIK treatment of moderate-to-high hyperopia. The overall rate of regression was low and the amount of regression was relatively small with both systems. Keywords: excimer laser, hyperopia, laser-assisted in situ keratomileusis, LASIK, regression
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- 2017
16. The use of WaveLight® Contoura to create a uniform cornea: the LYRA Protocol. Part 2: the consequences of treating astigmatism on an incorrect axis via excimer laser
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Motwani M
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Astigmatism ,corneal aberration ,excimer laser ,refractive surgery ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, USA Purpose: To show how an incorrect manifest astigmatism axis can cause an abnormal induced astigmatism on a new axis. Patients and methods: Four eyes of three patients were treated primarily with WaveLight® EX500 wavefront optimized (WFO) treatments for astigmatism. All four eyes needed enhancements and were analyzed retrospectively via WaveLight® Contoura to determine the reason for the incorrect astigmatism treatment. Two of the eyes were retreated with topographic-guided ablation, and two were treated with WFO correction. Results: The eyes that had an incorrect manifest axis resulted in a new abnormal induced astigmatism on a wholly new axis. Treatment with topographic-guided ablation completely eliminated the newly induced astigmatism. Treatment with WFO of an abnormal induced astigmatism corrected the refraction but still left topographic evidence of the abnormal astigmatism behind. One eye was incorrectly treated for astigmatism due to coma affecting refraction when the patient was dilated. This eye had a normal induced astigmatism on a perpendicular axis and was corrected using WFO. The use of manifest refraction with WaveLight® Contoura topographic-guided ablation will lead to incorrect astigmatism correction when the manifest astigmatism and axis differ from the WaveLight® Contoura measured. Conclusion: Correction of an incorrect manifest refraction astigmatic axis does not simply create undercorrection of the astigmatism but induces an entirely new abnormal astigmatism on a different axis. Manifest refraction is less accurate and can lead to abnormal astigmatism when laser ablation is performed. Keywords: WaveLight Contoura, astigmatism treatment, asymmetric astigmatism, topographic guide ablation, higher order aberrations, Contoura with LYRA Protocol, LASIK, PRK
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- 2017
17. The use of Wavelight® Contoura to create a uniform cornea: the LYRA protocol. Part 3: the results of 50 treated eyes
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Motwani M
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Astigmatism ,corneal aberration ,excimer laser ,refractive surgery ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, USA Purpose: To demonstrate how using the Wavelight Contoura measured astigmatism and axis eliminates corneal astigmatism and creates uniformly shaped corneas. Patients and methods: A retrospective analysis was conducted of the first 50 eyes to have bilateral full WaveLight® Contoura LASIK correction of measured astigmatism and axis (vs conventional manifest refraction), using the Layer Yolked Reduction of Astigmatism Protocol in all cases. All patients had astigmatism corrected, and had at least 1 week of follow-up. Accuracy to desired refractive goal was assessed by postoperative refraction, aberration reduction via calculation of polynomials, and postoperative visions were analyzed as a secondary goal. Results: The average difference of astigmatic power from manifest to measured was 0.5462D (with a range of 0–1.69D), and the average difference of axis was 14.94° (with a range of 0°–89°). Forty-seven of 50 eyes had a goal of plano, 3 had a monovision goal. Astigmatism was fully eliminated from all but 2 eyes, and 1 eye had regression with astigmatism. Of the eyes with plano as the goal, 80.85% were 20/15 or better, and 100% were 20/20 or better. Polynomial analysis postoperatively showed that at 6.5 mm, the average C3 was reduced by 86.5% and the average C5 by 85.14%. Conclusions: Using WaveLight® Contoura measured astigmatism and axis removes higher order aberrations and allows for the creation of a more uniform cornea with accurate removal of astigmatism, and reduction of aberration polynomials. WaveLight® Contoura successfully links the refractive correction layer and aberration repair layer using the Layer Yolked Reduction of Astigmatism Protocol to demonstrate how aberration removal can affect refractive correction. Keywords: WaveLight Contoura, topographic guided ablation, LASIK, PRK, uniform cornea, Contoura with LYRA Protocol, measured astigmatism
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- 2017
18. The use of Wavelight® Contoura to create a uniform cornea: the LYRA Protocol. Part 1: the effect of higher-order corneal aberrations on refractive astigmatism
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Motwani M
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Astigmatism ,corneal aberration ,refractive surgery ,trefoil ,quadrafoil ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, USA Purpose: To demonstrate how higher-order corneal aberrations can cancel out, modify, or induce lower-order corneal astigmatism. Patients and methods: Six representative eyes are presented that show different scenarios in which higher-order aberrations interacting with corneal astigmatism can affect the manifest refraction. WaveLight® Contoura ablation maps showing the higher-order aberrations are shown, as are results of correction with full measured correction using the LYRA (Layer Yolked Reduction of Astigmatism) Protocol. Results: Higher-order corneal aberrations such as trefoil, quadrafoil, and coma can create ovalization of the central cornea, which can interact with the ovalization caused by lower-order astigmatism to either induce, cancel out, or modify the manifest refraction. Contoura processing successfully determines the linkage of these interactions resulting in full astigmatism removal. Purely lenticular astigmatism appears to be rare, but a case is also demonstrated. The author theorizes that all aberrations require cerebral compensatory processing and can be removed, supported by the facts that full removal of aberrations and its linkage with lower-order astigmatism with the LYRA Protocol has not resulted in worse or unacceptable vision for any patients. Conclusion: Higher-order aberrations interacting with lower-order astigmatism is the main reason for the differences between manifest refraction and Contoura measured astigmatism, and the linkage between these interactions can be successfully treated using Contoura and the LYRA Protocol. Lenticular astigmatism is relatively rare. Keywords: topographic guided ablation, LASIK, PRK, WaveLight Contoura, uniform cornea, higher order aberrations
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- 2017
19. A protocol for topographic-guided corneal repair utilizing the US Food and Drug Administration-approved Wavelight Contoura
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Motwani M
- Subjects
Corneal ablation ,laser-assisted in situ keratomileusis ,LASIK ,photorefractive keratectomy ,PRK ,refractive surgery ,corneal irregularity ,corneal trauma ,decentered excimer laser ablations ,radial keratotomy ,higher order aberrations ,Ophthalmology ,RE1-994 - Abstract
Manoj Motwani Motwani LASIK Institute, San Diego, CA, USA Purpose: To demonstrate how Wavelight Contoura can be used to repair corneas damaged by trauma and prior poor surgical outcomes. Methods: Four representative eyes are presented that show different scenarios in which highly irregular corneas can be corrected with Wavelight Contoura using a protocol (named the San Diego Protocol) designed to use the information in Contoura processing. Both laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) were used. Results: Highly aberrant corneas with large amounts of warpage can be corrected safely with the Wavelight Contoura system. The San Diego Protocol requires individual analysis of each case with decisions based on the level of warpage and the level of epithelial hyperplastic compensation. The need for a second refractive power equalization procedure should be planned for. Conclusion: Contoura measured refraction can be integrally used as part of the San Diego Protocol to safely repair highly warped corneas. The refractive outcomes show dramatic improvement in vision, best-corrected visual acuity (BCVA), refraction, and topographic uniformity. Keywords: corneal ablation, laser-assisted in situ keratomileusis, photorefractive keratectomy, refractive surgery, corneal irregularity, corneal trauma, decentered excimer laser ablations, radial keratotomy, higher order aberrations
- Published
- 2017
20. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19
- Author
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Einstein, A, Hirschfeld, C, Williams, M, Vitola, J, Better, N, Villines, T, Cerci, R, Shaw, L, Choi, A, Dorbala, S, Karthikeyan, G, Lu, B, Sinitsyn, V, Ansheles, A, Kudo, T, Bucciarelli-Ducci, C, Norgaard, B, Maurovich-Horvat, P, Campisi, R, Milan, E, Louw, L, Allam, A, Bhatia, M, Sewanan, L, Malkovskiy, E, Cohen, Y, Randazzo, M, Narula, J, Morozova, O, Pascual, T, Pynda, Y, Dondi, M, Paez, D, Hinterleitner, G, Lu, Y, Xu, Z, Erinne, I, Shetty, M, Lopez-Mattei, J, Parwani, P, Goda, A, Shirka, E, Bouyoucef, S, Chelghoum, L, Mansouri, F, Medjahedi, A, Naili, Q, Ridouh, M, Alasia, D, Alberghina, L, Aramayo, N, Buchara, D, Busso, F, Bustos Rivadero, J, Camilletti, J, Campanelli, H, Castro, R, Daicz, M, del Riego, H, Dragonetti, L, Echazarreta, D, Erriest, J, Faccio, F, Facello, A, Gallegos, H, Geronazzo, R, Glait, H, Hasbani, V, Jager, V, Lewkowicz, J, Lotti, J, Maciel, N, Masoli, O, Mastrovito, E, Medus, M, Merani, M, Molteni, S, Montecinos, M, Parisi, G, Sueldo, C, Perez de Arenaza, D, 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J., Hirschfeld C., Williams M. C., Vitola J. V., Better N., Villines T. C., Cerci R., Shaw L. J., Choi A. D., Dorbala S., Karthikeyan G., Lu B., Sinitsyn V., Ansheles A. A., Kudo T., Bucciarelli-Ducci C., Norgaard B. L., Maurovich-Horvat P., Campisi R., Milan E., Louw L., Allam A. H., Bhatia M., Sewanan L., Malkovskiy E., Cohen Y., Randazzo M., Narula J., Morozova O., Pascual T. N. B., Pynda Y., Dondi M., Paez D., Hinterleitner G., Lu Y., Xu Z., Hirschfeld C. B., Erinne I., Shetty M., Choi A., Lopez-Mattei J., Parwani P., Goda A., Shirka E., Bouyoucef S., Chelghoum L., Mansouri F., Medjahedi A., Naili Q., Ridouh M., Alasia D., Alberghina L., Aramayo N., Buchara D., Busso F. G., Bustos Rivadero J. J., Camilletti J., Campanelli H., Castro R. B., Daicz M., del Riego H., Dragonetti L., Echazarreta D., Erriest J., Faccio F., Facello A., Gallegos H., Geronazzo R., Glait H., Hasbani V., Jager V., Lewkowicz J. M., Lotti J., Maciel N., Masoli O., Mastrovito E., Medus M., Merani M. 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N., Hanneman K., Miller R., Oikonomou A., Roifman I., Small G., Tandon V., Trivedi A., White J., Zukotynski K., Alay R., Concha C., Massardo T., Abad P., Anzola K., Arturo H., Benitez L., Cadena A., Zamudio C. C., Calderon A., Gutierrez Villamil C. T., Jaimes C., Londono J. L., Lopez N., Merlano-Gaitan S., Murgieitio-Cabrera R., Valencia M., Vergel D., Santamaria A. Z., Solis F., Batinic T., Franceschi M., Paar M. H., Prpic M., Felipe Batista C. J., Cabrera L. O., Peix A., Pena Y., Rochela Vazquez L. M., Ntalas I., Kaminek M., Kincl V., Lang O., Abdulla J., Bottcher M., Busk M., Geisler U., Gormsen L. C., Hansson N., Hess S., Hove J., Jensen L. T., Jensen M. T., Kragholm K. H., Ovrehus K., Rasmussen J., Ronnow Sand N. P., Sondergaard H., Zaremba T., Speckter H., Amores N., Velez M. S., Alrahman T. A., Elsamad S. A., Abdelfattah A., Allam A., Elkaffas S., Hassan M., Hussein E., Ibrahim A., Kandeel A., Ali M. M., Shaaban M., Flores C., Gomez Leiva V. V., Liiver A., Larikka M., Uusitalo V., Agostini D., Berger C., Dietz M., Hyafil F., Ohana M., Prigent K., Regaieg H., Sarda-Mantel L., H-Ici D. O., Ayetey H., Angelidis G., Fragkaki C., Fragkiadaki C., Georgoulias P., Koutelou M., Kyrozi E., Lama N., Prassopoulos V., Spartalis M., Zaglavara T., Gonzalez C., Gutierrez G., Maldonado A., Martinez Y., Kovacs A., Szilveszter B., Banthia N., Bhat V., Choudhury P., Chowdekar V. S., Christopher J., Garg T., Goyal N. K., Gupta R. K., Gupta A., Hephzibah J., Jain S., Krupa J., Kumar P., Kumar S., Lalchandani A., Mishra A., Mishra V. D., Mohan P., Ozair A., Pandey S., Parameswaran R., Patel C., Patel T., Patel S., Vimala L. R., Kumar Sarangi D. P., Sengupta S., Sethi A., Sharma A., Sharma A. K., Sharma P., Shrigiriwar A., Singh S., Singh H., Sood A., Verma A., Vyas A., Soeriadi E. A., Bun E., Hutomo F., Syawaluddin H., Yudistiro R., Albadr A., Assadi M., Emami F., Emami-Ardekani A., Farzanehfar S., Jafari R., Manafi-Farid R., Tajik M., Arnson Y., Fuchs S., Goldkorn R., Kennedy J., Leitman M., Shalev A., Acampa W., Albano D., Alongi P., Arnone G., Assante R., Baritussio A., Bauckneht M., Bianco F., Bonfiglioli R., Bovenzi F., Bruno I., Bruno A., Busnardo E., Califaretti E., Casoni R., Censullo V., Chierichetti F., Chiocchi M., Cittanti C., Clemente A., Cuocolo A., De Rimini M. L., De Vincentis G., Della Tommasina V., Dellegrottaglie S., Erba P. 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- Abstract
Background: The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown. Objectives: The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide. Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery. Results: Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians’ psychological stress were significant in predicting recovery of cardiac testing. Conclusions: Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing.
- Published
- 2022
21. Efficacy of transcutaneous electrical nerve stimulation (TENS) in the management of trigeminal neuralgia: A systematic review and meta-analysis
- Author
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Motwani, M., primary, Fadnavis, A., additional, and Dhole, A., additional
- Published
- 2023
- Full Text
- View/download PDF
22. 214MO Sacituzumab govitecan (SG) efficacy in hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (MBC) by HER2 immunohistochemistry (IHC) status in the phase III TROPiCS-02 study
- Author
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Schmid, P., primary, Cortés, J., additional, Marmé, F., additional, Rugo, H.S., additional, Tolaney, S.M., additional, Oliveira, M., additional, Loirat, D., additional, Jhaveri, K., additional, Yoon, O.K., additional, Motwani, M., additional, Wang, H., additional, Delaney, R.J., additional, and Bardia, A., additional
- Published
- 2022
- Full Text
- View/download PDF
23. 30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data
- Author
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Singhal R., Cardoso V. R., Wiggins T., Super J., Ludwig C., Gkoutos G. V., Mahawar K., Pedziwiatr M., Major P., Zarzycki P., Pantelis A., Lapatsanis D. P., Stravodimos G., Matthys C., Focquet M., Vleeschouwers W., Spaventa A. G., Zerrweck C., Vitiello A., Berardi G., Musella M., Sanchez-Meza A., Cantu F. J., Mora F., Cantu M. A., Katakwar A., Reddy D. N., Elmaleh H., Hassan M., Elghandour A., Elbanna M., Osman A., Khan A., layani L., Kiran N., Velikorechin A., Solovyeva M., Melali H., Shahabi S., Agrawal A., Shrivastava A., Sharma A., Narwaria B., Narwaria M., Raziel A., Sakran N., Susmallian S., Karagoz L., Akbaba M., Piskin S. Z., Balta A. Z., Senol Z., Manno E., Iovino M. G., Qassem M., Arana-Garza S., Povoas H. P., Vilas-Boas M. L., Naumann D., Li A., Ammori B. J., Balamoun H., Salman M., Nasta A. M., Goel R., Sanchez-Aguilar H., Herrera M. F., Abou-mrad A., Cloix L., Mazzini G. S., Kristem L., Lazaro A., Campos J., Bernardo J., Gonzalez J., Trindade C., Viveiros O., Ribeiro R., Goitein D., Hazzan D., Segev L., Beck T., Reyes H., Monterrubio J., Garcia P., Benois M., Kassir R., Contine A., Elshafei M., Aktas S., Weiner S., Heidsieck T., Level L., Pinango S., Ortega P. M., Moncada R., Valenti V., Vlahovic I., Boras Z., Liagre A., Martini F., Juglard G., Motwani M., Saggu S. S., Momani H. A., Lopez L. A. A., Cortez M. A. C., Zavala R. A., D'Haese RN C., Kempeneers I., Himpens J., Lazzati A., Paolino L., Bathaei S., Bedirli A., Yavuz A., Buyukkasap C., Ozaydin S., Kwiatkowski A., Bartosiak K., Waledziak M., Santonicola A., Angrisani L., Iovino P., Palma R., Iossa A., Boru C. E., De Angelis F., Silecchia G., Hussain A., Balchandra S., Coltell I. B., Perez J. L., Bohra A., Awan A. K., Madhok B., Leeder P. C., Awad S., Al-Khyatt W., Shoma A., Elghadban H., Ghareeb S., Mathews B., Kurian M., Larentzakis A., Vrakopoulou G. 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A., Chowbey P., Soni V., de Vasconcelos Cunha H. A., Castilho M. V., Ferreira R. M. A., Barreiro T. A., Charalabopoulos A., Sdralis E., Davakis S., Bomans B., Dapri G., Van Belle K., Takieddine M., Vaneukem P., Karaca E. S. A., Karaca F. C., Sumer A., Peksen C., Savas O. A., Chousleb E., Elmokayed F., Fakhereldin I., Aboshanab H. M., Swelium T., Gudal A., Gamloo L., Ugale A., Ugale S., Boeker C., Reetz C., Hakami I. A., Mall J., Alexandrou A., Baili E., Bodnar Z., Maleckas A., Gudaityte R., Guldogan C. E., Gundogdu E., Ozmen M. M., Thakkar D., Dukkipati N., Shah P. S., Shah S. S., Adil M. T., Jambulingam P., Mamidanna R., Whitelaw D., Jain V., Veetil D. K., Wadhawan R., Torres M., Tinoco T., Leclercq W., Romeijn M., van de Pas K., Alkhazraji A. K., Taha S. A., Ustun M., Yigit T., Inam A., Burhanulhaq M., Pazouki A., Eghbali F., Kermansaravi M., Jazi A. H. D., Mahmoudieh M., Mogharehabed N., Tsiotos G., Stamou K., Rodriguez F. J. B., Navarro M. A. R., Torres O. M., Martinez S. L., Tamez E. R. M., Cornejo G. A. M., Flores J. E. G., Mohammed D. A., Elfawal M. H., Shabbir A., Guowei K., So J. B., Kaplan E. T., Kaplan M., Kaplan T., Pham D. T., Rana G., Kappus M., Gadani R., Kahitan M., Pokharel K., Osborne A., Pournaras D., Hewes J., Napolitano E., Chiappetta S., Bottino V., Dorado E., Schoettler A., Gaertner D., Fedtke K., Aguilar-Espinosa F., Aceves-Lozano S., Balani A., Nagliati C., Pennisi D., Rizzi A., Frattini F., Foschi D., Benuzzi L., Parikh C., Shah H., Pinotti E., Montuori M., Borrelli V., Dargent J., Copaescu C. A., Hutopila I., Smeu B., Witteman B., Hazebroek E., Deden L., Heusschen L., Okkema S., Aufenacker T., den Hengst W., Vening W., van der Burgh Y., Ghazal A., Ibrahim H., Niazi M., Alkhaffaf B., Altarawni M., Cesana G. C., Anselmino M., Uccelli M., Olmi S., Stier C., Akmanlar T., Sonnenberg T., Schieferbein U., Marcolini A., Awruch D., Vicentin M., de Souza Bastos E. L., Gregorio S. A., Ahuja A., Mittal T., Bolckmans R., Baratte C., Wisnewsky J. A., Genser L., Chong L., Taylor L., Ward S., Hi M. W., Heneghan H., Fearon N., Plamper A., Rheinwalt K., Geoghegan J., Ng K. C., Kaseja K., Kotowski M., Samarkandy T. A., Leyva-Alvizo A., Corzo-Culebro L., Wang C., Yang W., Dong Z., Riera M., Jain R., Hamed H., Said M., Zarzar K., Garcia M., Turkcapar A. G., Sen O., Baldini E., Conti L., Wietzycoski C., Lopes E., Pintar T., Salobir J., Aydin C., Atici S. D., Ergin A., Ciyiltepe H., Bozkurt M. A., Kizilkaya M. C., Onalan N. B. D., Zuber M. N. B. A., Wong W. J., Garcia A., Vidal L., Beisani M., Pasquier J., Vilallonga R., Sharma S., Parmar C., Lee L., Sufi P., Sinan H., Saydam M., Singhal, R., Cardoso, V. R., Wiggins, T., Super, J., Ludwig, C., Gkoutos, G. V., Mahawar, K., Pedziwiatr, M., Major, P., Zarzycki, P., Pantelis, A., Lapatsanis, D. P., Stravodimos, G., Matthys, C., Focquet, M., Vleeschouwers, W., Spaventa, A. G., Zerrweck, C., Vitiello, A., Berardi, G., Musella, M., Sanchez-Meza, A., Cantu, F. J., Mora, F., Cantu, M. A., Katakwar, A., Reddy, D. N., Elmaleh, H., Hassan, M., Elghandour, A., Elbanna, M., Osman, A., Khan, A., Layani, L., Kiran, N., Velikorechin, A., Solovyeva, M., Melali, H., Shahabi, S., Agrawal, A., Shrivastava, A., Sharma, A., Narwaria, B., Narwaria, M., Raziel, A., Sakran, N., Susmallian, S., Karagoz, L., Akbaba, M., Piskin, S. Z., Balta, A. Z., Senol, Z., Manno, E., Iovino, M. G., Qassem, M., Arana-Garza, S., Povoas, H. P., Vilas-Boas, M. L., Naumann, D., Li, A., Ammori, B. J., Balamoun, H., Salman, M., Nasta, A. M., Goel, R., Sanchez-Aguilar, H., Herrera, M. F., Abou-mrad, A., Cloix, L., Mazzini, G. S., Kristem, L., Lazaro, A., Campos, J., Bernardo, J., Gonzalez, J., Trindade, C., Viveiros, O., Ribeiro, R., Goitein, D., Hazzan, D., Segev, L., Beck, T., Reyes, H., Monterrubio, J., Garcia, P., Benois, M., Kassir, R., Contine, A., Elshafei, M., Aktas, S., Weiner, S., Heidsieck, T., Level, L., Pinango, S., Ortega, P. M., Moncada, R., Valenti, V., Vlahovic, I., Boras, Z., Liagre, A., Martini, F., Juglard, G., Motwani, M., Saggu, S. S., Momani, H. A., Lopez, L. A. A., Cortez, M. A. C., Zavala, R. A., D'Haese RN, C., Kempeneers, I., Himpens, J., Lazzati, A., Paolino, L., Bathaei, S., Bedirli, A., Yavuz, A., Buyukkasap, C., Ozaydin, S., Kwiatkowski, A., Bartosiak, K., Waledziak, M., Santonicola, A., Angrisani, L., Iovino, P., Palma, R., Iossa, A., Boru, C. E., De Angelis, F., Silecchia, G., Hussain, A., Balchandra, S., Coltell, I. B., Perez, J. L., Bohra, A., Awan, A. K., Madhok, B., Leeder, P. C., Awad, S., Al-Khyatt, W., Shoma, A., Elghadban, H., Ghareeb, S., Mathews, B., Kurian, M., Larentzakis, A., Vrakopoulou, G. Z., Albanopoulos, K., Bozdag, A., Lale, A., Kirkil, C., Dincer, M., Bashir, A., Haddad, A., Hijleh, L. A., Zilberstein, B., de Marchi, D. D., Souza, W. P., Broden, C. M., Gislason, H., Shah, K., Ambrosi, A., Pavone, G., Tartaglia, N., Kona, S. L. K., Kalyan, K., Perez, C. E. G., Botero, M. A. F., Covic, A., Timofte, D., Maxim, M., Faraj, D., Tseng, L., Liem, R., Oren, G., Dilektasli, E., Yalcin, I., Almukhtar, H., Hadad, M. A., Mohan, R., Arora, N., Bedi, D., Rives-Lange, C., Chevallier, J. -M., Poghosyan, T., Sebbag, H., Zinai, L., Khaldi, S., Mauchien, C., Mazza, D., Dinescu, G., Rea, B., Perez-Galaz, F., Zavala, L., Besa, A., Curell, A., Balibrea, J. M., Vaz, C., Galindo, L., Silva, N., Caballero, J. L. E., Sebastian, S. O., Marchesini, J. C. D., da Fonseca Pereira, R. A., Sobottka, W. H., Fiolo, F. E., Turchi, M., Coelho, A. C. J., Zacaron, A. L., Barbosa, A., Quinino, R., Menaldi, G., Paleari, N., Martinez-Duartez, P., de Esparza, G. M. A. R., Esteban, V. S., Torres, A., Garcia-Galocha, J. L., Josa, M., Pacheco-Garcia, J. M., Mayo-Ossorio, M. A., Chowbey, P., Soni, V., de Vasconcelos Cunha, H. A., Castilho, M. V., Ferreira, R. M. A., Barreiro, T. A., Charalabopoulos, A., Sdralis, E., Davakis, S., Bomans, B., Dapri, G., Van Belle, K., Takieddine, M., Vaneukem, P., Karaca, E. S. A., Karaca, F. C., Sumer, A., Peksen, C., Savas, O. A., Chousleb, E., Elmokayed, F., Fakhereldin, I., Aboshanab, H. M., Swelium, T., Gudal, A., Gamloo, L., Ugale, A., Ugale, S., Boeker, C., Reetz, C., Hakami, I. A., Mall, J., Alexandrou, A., Baili, E., Bodnar, Z., Maleckas, A., Gudaityte, R., Guldogan, C. E., Gundogdu, E., Ozmen, M. M., Thakkar, D., Dukkipati, N., Shah, P. S., Shah, S. S., Adil, M. T., Jambulingam, P., Mamidanna, R., Whitelaw, D., Jain, V., Veetil, D. K., Wadhawan, R., Torres, M., Tinoco, T., Leclercq, W., Romeijn, M., van de Pas, K., Alkhazraji, A. K., Taha, S. A., Ustun, M., Yigit, T., Inam, A., Burhanulhaq, M., Pazouki, A., Eghbali, F., Kermansaravi, M., Jazi, A. H. D., Mahmoudieh, M., Mogharehabed, N., Tsiotos, G., Stamou, K., Rodriguez, F. J. B., Navarro, M. A. R., Torres, O. M., Martinez, S. L., Tamez, E. R. M., Cornejo, G. A. M., Flores, J. E. G., Mohammed, D. A., Elfawal, M. H., Shabbir, A., Guowei, K., So, J. B., Kaplan, E. T., Kaplan, M., Kaplan, T., Pham, D. T., Rana, G., Kappus, M., Gadani, R., Kahitan, M., Pokharel, K., Osborne, A., Pournaras, D., Hewes, J., Napolitano, E., Chiappetta, S., Bottino, V., Dorado, E., Schoettler, A., Gaertner, D., Fedtke, K., Aguilar-Espinosa, F., Aceves-Lozano, S., Balani, A., Nagliati, C., Pennisi, D., Rizzi, A., Frattini, F., Foschi, D., Benuzzi, L., Parikh, C., Shah, H., Pinotti, E., Montuori, M., Borrelli, V., Dargent, J., Copaescu, C. A., Hutopila, I., Smeu, B., Witteman, B., Hazebroek, E., Deden, L., Heusschen, L., Okkema, S., Aufenacker, T., den Hengst, W., Vening, W., van der Burgh, Y., Ghazal, A., Ibrahim, H., Niazi, M., Alkhaffaf, B., Altarawni, M., Cesana, G. C., Anselmino, M., Uccelli, M., Olmi, S., Stier, C., Akmanlar, T., Sonnenberg, T., Schieferbein, U., Marcolini, A., Awruch, D., Vicentin, M., de Souza Bastos, E. L., Gregorio, S. A., Ahuja, A., Mittal, T., Bolckmans, R., Baratte, C., Wisnewsky, J. A., Genser, L., Chong, L., Taylor, L., Ward, S., Hi, M. W., Heneghan, H., Fearon, N., Plamper, A., Rheinwalt, K., Geoghegan, J., Ng, K. C., Kaseja, K., Kotowski, M., Samarkandy, T. A., Leyva-Alvizo, A., Corzo-Culebro, L., Wang, C., Yang, W., Dong, Z., Riera, M., Jain, R., Hamed, H., Said, M., Zarzar, K., Garcia, M., Turkcapar, A. G., Sen, O., Baldini, E., Conti, L., Wietzycoski, C., Lopes, E., Pintar, T., Salobir, J., Aydin, C., Atici, S. D., Ergin, A., Ciyiltepe, H., Bozkurt, M. A., Kizilkaya, M. C., Onalan, N. B. D., Zuber, M. N. B. A., Wong, W. J., Garcia, A., Vidal, L., Beisani, M., Pasquier, J., Vilallonga, R., Sharma, S., Parmar, C., Lee, L., Sufi, P., Sinan, H., Saydam, M., İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Sumer, Aziz, Peksen, Caghan, and Savas, Osman Anil
- Subjects
Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Gastric Bypass ,Medicine (miscellaneous) ,nutritional and metabolic diseases ,COVID-19 ,Gastrectomy ,Humans ,Morbidity ,Propensity Score ,Retrospective Studies ,Treatment Outcome ,Diabetes Mellitus, Type 2 ,Obesity, Morbid ,Article ,Diabetes Mellitus ,Obesity ,Morbid ,Type 2 - Abstract
Background There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts.
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- 2021
24. Modeling the initiation of Ewing sarcoma tumorigenesis in differentiating human embryonic stem cells
- Author
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Gordon, D J, Motwani, M, and Pellman, D
- Published
- 2016
- Full Text
- View/download PDF
25. MO31-2 Telisotuzumab vedotin monotherapy in patients with previously treated c-Met+ advanced non-small cell lung cancer
- Author
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Horinouchi, Hidehito, primary, Goldman, J.W., additional, Moiseenko, F., additional, Cicin, I., additional, Filippova, E., additional, Bar, J., additional, Tomasini, P., additional, Ocampo, C., additional, Sullivan, D., additional, Maag, D., additional, Motwani, M., additional, Jin, J., additional, and Camidge, D.R., additional
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- 2022
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- View/download PDF
26. Evaluation of Enamel Solubility on Exposure to Hard Drinks: An In-Vitro Study
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Charpe Mp and Motwani M
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Chromatography ,Enamel paint ,Chemistry ,visual_art ,visual_art.visual_art_medium ,In vitro study ,Solubility ,General Dentistry - Published
- 2019
27. 30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic – The GENEVA study
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Singhal R., Wiggins T., Super J., Alqahtani A., Nadler E. P., Ludwig C., Tahrani A., Mahawar K., Pedziwiatr M., Major P., Zarzycki P., Pantelis A., Lapatsanis D. P., Stravodimos G., Matthys C., Focquet M., Vleeschouwers W., Spaventa A. G., Zerrweck C., Vitiello A., Berardi G., Musella M., Sanchez-Meza A., Cantu F. J., Mora F., Cantu M. A., Katakwar A., Reddy D. N., Elmaleh H., Hassan M., Elghandour A., Elbanna M., Osman A., Khan A., Layani L., Kiran N., Velikorechin A., Solovyeva M., Melali H., Shahabi S., Agrawal A., Shrivastava A., Sharma A., Narwaria B., Narwaria M., Raziel A., Sakran N., Susmallian S., Karagoz L., Akbaba M., Piskin S. Z., Ziya A., Senol Z., Manno E., Iovino M. G., Qassem M., Arana-Garza S., Povoas H. P., Vilas-Boas M. L., Naumann D., Li A., Ammori B. J., Balamoun H., Salman M., Nasta A. M., Goel R., Sanchez-Aguilar H., Herrera M. F., Abou-Mrad A., Cloix L., Mazzini G. S., Kristem L., Lazaro A., Campos J., Bernardo J., Gonzalez J., Trindade C., Viveiros O., Ribeiro R., Goitein D., Hazzan D., Segev L., Beck T., Reyes H., Monterrubio J., Garcia P., Benois M., Kassir R., Contine A., Elshafei M., Aktas S., Weiner S., Heidsieck T., Level L., Pinango S., Ortega P. M., Moncada R., Valenti V., Vlahovic I., Boras Z., Liagre A., Martini F., Juglard G., Motwani M., Saggu S. S., Al Momani H., Lopez L. A. A., Cortez M. A. C., Zavala R. A., D'Haese C., Kempeneers I., Himpens J., Lazzati A., Paolino L., Bathaei S., Bedirli A., Yavuz A., Buyukkasap C., Ozaydin S., Kwiatkowski A., Bartosiak K., Waledziak M., Santonicola A., Angrisani L., Iovino P., Palma R., Iossa A., Boru C. E., De Angelis F., Silecchia G., Hussain A., Balchandra S., Coltell I. B., Perez J. L., Bohra A., Awan A. K., Madhok B., Leeder P. C., Awad S., Al-Khyatt W., Shoma A., Elghadban H., Ghareeb S., Mathews B., Kurian M., Larentzakis A., Vrakopoulou G. Z., Albanopoulos K., Bozdag A., Lale A., Kirkil C., Dincer M., Bashir A., Haddad A., Hijleh L. A., Zilberstein B., de Marchi D. D., Souza W. P., Broden C. M., Gislason H., Shah K., Ambrosi A., Pavone G., Tartaglia N., Kona S. L. K., Kalyan K., Perez C. E. G., Botero M. A. F., Covic A., Timofte D., Maxim M., Faraj D., Tseng L., Liem R., Oren G., Dilektasli E., Yalcin I., AlMukhtar H., Al Hadad M., Mohan R., Arora N., Bedi D., Rives-Lange C., Chevallier J. -M., Poghosyan T., Sebbag H., Zinai L., Khaldi S., Mauchien C., Mazza D., Dinescu G., Rea B., Perez-Galaz F., Zavala L., Besa A., Curell A., Balibrea J. M., Vaz C., Galindo L., Silva N., Caballero J. L. E., Sebastian S. O., Marchesini J. C. D., da Fonseca Pereira R. A., Sobottka W. H., Fiolo F. E., Turchi M., Coelho A. C. J., Zacaron A. L., Barbosa A., Quinino R., Menaldi G., Paleari N., Martinez-Duartez P., Aragon Ramirez de Esparza D. G. M., Esteban V. S., Torres A., Garcia-Galocha J. L., Josa M. I., Pacheco-Garcia J. M., Mayo-Ossorio M. A., Chowbey P., Soni V., de Vasconcelos Cunha H. A., Castilho M. V., Ferreira R. M. A., Barreiro T. A., Charalabopoulos A., Sdralis E., Davakis S., Bomans B., Dapri G., Van Belle K., MazenTakieddine, Vaneukem P., Karaca E. S. A., Karaca F. C., Sumer A., Peksen C., Savas O. A., Chousleb E., Elmokayed F., Fakhereldin I., Aboshanab H. M., Swelium T., Gudal A., Gamloo L., Ugale A., Ugale S., Boeker C., Reetz C., Hakami I. A., Mall J., Alexandrou A., Baili E., Bodnar Z., Maleckas A., Gudaityte R., Guldogan C. E., Gundogdu E., Ozmen M. M., Thakkar D., Dukkipati N., Shah P. S., Shah S. S., Adil M. T., Jambulingam P., Mamidanna R., Whitelaw D., Jain V., Veetil D. K., Wadhawan R., Torres M., Tinoco T., Leclercq W., Romeijn M., van de Pas K., Alkhazraji A. K., Taha S. A., Ustun M., Yigit T., Inam A., Burhanulhaq M., Pazouki A., Eghbali F., Kermansaravi M., Jazi A. H. D., Mahmoudieh M., Mogharehabed N., Tsiotos G., Stamou K., Barrera Rodriguez F. J., Rojas Navarro M. A., Torres O. M. O., Martinez S. L., Tamez E. R. M., Millan Cornejo G. A., Flores J. E. G., Mohammed D. A., Elfawal M. H., Shabbir A., Guowei K., So J. B. Y., Kaplan E. T., Kaplan M., Kaplan T., Pham D. T., Rana G., Kappus M., Gadani R., Kahitan M., Pokharel K., Osborne A., Pournaras D., Hewes J., Napolitano E., Chiappetta S., Bottino V., Dorado E., Schoettler A., Gaertner D., Fedtke K., Aguilar-Espinosa F., Aceves-Lozano S., Balani A., Nagliati C., Pennisi D., Rizzi A., Frattini F., Foschi D., Benuzzi L., Parikh C. H. I. R. A. G., Shah H. A. R. S. H. I. L., Pinotti E., Montuori M., Borrelli V., Dargent J., Copaescu C. A., Hutopila I., Smeu B., Witteman B., Hazebroek E., Deden L., Heusschen L., Okkema S., Aufenacker T., den Hengst W., Vening W., van der Burgh Y., Ghazal A., Ibrahim H., Niazi M., Alkhaffaf B., Altarawni M., Cesana G. C., Anselmino M., Uccelli M., Olmi S., Stier C., Akmanlar T., Sonnenberg T., Schieferbein U., Marcolini A., Awruch D., Vicentin M., de Souza Bastos E. L., Gregorio S. A., Ahuja A., Mittal T., Bolckmans R., Baratte C., Wisnewsky J. A., Genser L., Chong L., Taylor L., Ward S., Hi M. W., Heneghan H., Fearon N., Plamper A., Rheinwalt K., Geoghegan J., Ng K. C., Kaseja K., Kotowski M., Samarkandy T. A., Leyva-Alvizo A., Corzo-Culebro L., Wang C., Yang W., Dong Z., Riera M., Jain R., Hamed H., Said M., Zarzar K., Garcia M., Turkcapar A. G., Sen O., Baldini E., Conti L., Wietzycoski C., Lopes E., Pintar T., Salobir J., Aydin C., Atici S. D., Ergin A., Ciyiltepe H., Bozkurt M. A., Kizilkaya M. C., Onalan N. B. D., Zuber M. N. B. A., Wong W. J., Garcia A., Vidal L., Beisani M., Pasquier J., Vilallonga R., Sharma S., Parmar C., Lee L., Sufi P., Sinan H., Saydam M., Singhal, R., Wiggins, T., Super, J., Alqahtani, A., Nadler, E. P., Ludwig, C., Tahrani, A., Mahawar, K., Pedziwiatr, M., Major, P., Zarzycki, P., Pantelis, A., Lapatsanis, D. P., Stravodimos, G., Matthys, C., Focquet, M., Vleeschouwers, W., Spaventa, A. G., Zerrweck, C., Vitiello, A., Berardi, G., Musella, M., Sanchez-Meza, A., Cantu, F. J., Mora, F., Cantu, M. A., Katakwar, A., Reddy, D. N., Elmaleh, H., Hassan, M., Elghandour, A., Elbanna, M., Osman, A., Khan, A., Layani, L., Kiran, N., Velikorechin, A., Solovyeva, M., Melali, H., Shahabi, S., Agrawal, A., Shrivastava, A., Sharma, A., Narwaria, B., Narwaria, M., Raziel, A., Sakran, N., Susmallian, S., Karagoz, L., Akbaba, M., Piskin, S. Z., Ziya, A., Senol, Z., Manno, E., Iovino, M. G., Qassem, M., Arana-Garza, S., Povoas, H. P., Vilas-Boas, M. L., Naumann, D., Li, A., Ammori, B. J., Balamoun, H., Salman, M., Nasta, A. M., Goel, R., Sanchez-Aguilar, H., Herrera, M. F., Abou-Mrad, A., Cloix, L., Mazzini, G. S., Kristem, L., Lazaro, A., Campos, J., Bernardo, J., Gonzalez, J., Trindade, C., Viveiros, O., Ribeiro, R., Goitein, D., Hazzan, D., Segev, L., Beck, T., Reyes, H., Monterrubio, J., Garcia, P., Benois, M., Kassir, R., Contine, A., Elshafei, M., Aktas, S., Weiner, S., Heidsieck, T., Level, L., Pinango, S., Ortega, P. M., Moncada, R., Valenti, V., Vlahovic, I., Boras, Z., Liagre, A., Martini, F., Juglard, G., Motwani, M., Saggu, S. S., Al Momani, H., Lopez, L. A. A., Cortez, M. A. C., Zavala, R. A., D'Haese, C., Kempeneers, I., Himpens, J., Lazzati, A., Paolino, L., Bathaei, S., Bedirli, A., Yavuz, A., Buyukkasap, C., Ozaydin, S., Kwiatkowski, A., Bartosiak, K., Waledziak, M., Santonicola, A., Angrisani, L., Iovino, P., Palma, R., Iossa, A., Boru, C. E., De Angelis, F., Silecchia, G., Hussain, A., Balchandra, S., Coltell, I. B., Perez, J. L., Bohra, A., Awan, A. K., Madhok, B., Leeder, P. C., Awad, S., Al-Khyatt, W., Shoma, A., Elghadban, H., Ghareeb, S., Mathews, B., Kurian, M., Larentzakis, A., Vrakopoulou, G. Z., Albanopoulos, K., Bozdag, A., Lale, A., Kirkil, C., Dincer, M., Bashir, A., Haddad, A., Hijleh, L. A., Zilberstein, B., de Marchi, D. D., Souza, W. P., Broden, C. M., Gislason, H., Shah, K., Ambrosi, A., Pavone, G., Tartaglia, N., Kona, S. L. K., Kalyan, K., Perez, C. E. G., Botero, M. A. F., Covic, A., Timofte, D., Maxim, M., Faraj, D., Tseng, L., Liem, R., Oren, G., Dilektasli, E., Yalcin, I., Almukhtar, H., Al Hadad, M., Mohan, R., Arora, N., Bedi, D., Rives-Lange, C., Chevallier, J. -M., Poghosyan, T., Sebbag, H., Zinai, L., Khaldi, S., Mauchien, C., Mazza, D., Dinescu, G., Rea, B., Perez-Galaz, F., Zavala, L., Besa, A., Curell, A., Balibrea, J. M., Vaz, C., Galindo, L., Silva, N., Caballero, J. L. E., Sebastian, S. O., Marchesini, J. C. D., da Fonseca Pereira, R. A., Sobottka, W. H., Fiolo, F. E., Turchi, M., Coelho, A. C. J., Zacaron, A. L., Barbosa, A., Quinino, R., Menaldi, G., Paleari, N., Martinez-Duartez, P., Aragon Ramirez de Esparza, D. G. M., Esteban, V. S., Torres, A., Garcia-Galocha, J. L., Josa, M. I., Pacheco-Garcia, J. M., Mayo-Ossorio, M. A., Chowbey, P., Soni, V., de Vasconcelos Cunha, H. A., Castilho, M. V., Ferreira, R. M. A., Barreiro, T. A., Charalabopoulos, A., Sdralis, E., Davakis, S., Bomans, B., Dapri, G., Van Belle, K., Mazentakieddine, Vaneukem, P., Karaca, E. S. A., Karaca, F. C., Sumer, A., Peksen, C., Savas, O. A., Chousleb, E., Elmokayed, F., Fakhereldin, I., Aboshanab, H. M., Swelium, T., Gudal, A., Gamloo, L., Ugale, A., Ugale, S., Boeker, C., Reetz, C., Hakami, I. A., Mall, J., Alexandrou, A., Baili, E., Bodnar, Z., Maleckas, A., Gudaityte, R., Guldogan, C. E., Gundogdu, E., Ozmen, M. M., Thakkar, D., Dukkipati, N., Shah, P. S., Shah, S. S., Adil, M. T., Jambulingam, P., Mamidanna, R., Whitelaw, D., Jain, V., Veetil, D. K., Wadhawan, R., Torres, M., Tinoco, T., Leclercq, W., Romeijn, M., van de Pas, K., Alkhazraji, A. K., Taha, S. A., Ustun, M., Yigit, T., Inam, A., Burhanulhaq, M., Pazouki, A., Eghbali, F., Kermansaravi, M., Jazi, A. H. D., Mahmoudieh, M., Mogharehabed, N., Tsiotos, G., Stamou, K., Barrera Rodriguez, F. J., Rojas Navarro, M. A., Torres, O. M. O., Martinez, S. L., Tamez, E. R. M., Millan Cornejo, G. A., Flores, J. E. G., Mohammed, D. A., Elfawal, M. H., Shabbir, A., Guowei, K., So, J. B. Y., Kaplan, E. T., Kaplan, M., Kaplan, T., Pham, D. T., Rana, G., Kappus, M., Gadani, R., Kahitan, M., Pokharel, K., Osborne, A., Pournaras, D., Hewes, J., Napolitano, E., Chiappetta, S., Bottino, V., Dorado, E., Schoettler, A., Gaertner, D., Fedtke, K., Aguilar-Espinosa, F., Aceves-Lozano, S., Balani, A., Nagliati, C., Pennisi, D., Rizzi, A., Frattini, F., Foschi, D., Benuzzi, L., Parikh, C. H. I. R. A. G., Shah, H. A. R. S. H. I. L., Pinotti, E., Montuori, M., Borrelli, V., Dargent, J., Copaescu, C. A., Hutopila, I., Smeu, B., Witteman, B., Hazebroek, E., Deden, L., Heusschen, L., Okkema, S., Aufenacker, T., den Hengst, W., Vening, W., van der Burgh, Y., Ghazal, A., Ibrahim, H., Niazi, M., Alkhaffaf, B., Altarawni, M., Cesana, G. C., Anselmino, M., Uccelli, M., Olmi, S., Stier, C., Akmanlar, T., Sonnenberg, T., Schieferbein, U., Marcolini, A., Awruch, D., Vicentin, M., de Souza Bastos, E. L., Gregorio, S. A., Ahuja, A., Mittal, T., Bolckmans, R., Baratte, C., Wisnewsky, J. A., Genser, L., Chong, L., Taylor, L., Ward, S., Hi, M. W., Heneghan, H., Fearon, N., Plamper, A., Rheinwalt, K., Geoghegan, J., Ng, K. C., Kaseja, K., Kotowski, M., Samarkandy, T. A., Leyva-Alvizo, A., Corzo-Culebro, L., Wang, C., Yang, W., Dong, Z., Riera, M., Jain, R., Hamed, H., Said, M., Zarzar, K., Garcia, M., Turkcapar, A. G., Sen, O., Baldini, E., Conti, L., Wietzycoski, C., Lopes, E., Pintar, T., Salobir, J., Aydin, C., Atici, S. D., Ergin, A., Ciyiltepe, H., Bozkurt, M. A., Kizilkaya, M. C., Onalan, N. B. D., Zuber, M. N. B. A., Wong, W. J., Garcia, A., Vidal, L., Beisani, M., Pasquier, J., Vilallonga, R., Sharma, S., Parmar, C., Lee, L., Sufi, P., Sinan, H., and Saydam, M.
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Male ,Pediatrics ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,bariatric surgery ,Context (language use) ,Pandemic ,Medicine ,Humans ,Pandemics ,COVID-19 ,pandemic ,SARS-CoV-2 ,Nutrition and Dietetics ,Manchester Cancer Research Centre ,business.industry ,Health Policy ,ResearchInstitutes_Networks_Beacons/mcrc ,Public Health, Environmental and Occupational Health ,medicine.disease ,Obesity ,Obesity, Morbid ,Treatment Outcome ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Morbidity ,business ,Body mass index ,Cohort study ,Human - Abstract
Background: Metabolic and bariatric surgery (MBS) is an effective treatment for adolescents with severe obesity. Objectives: This study examined the safety of MBS in adolescents during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This was a global, multicentre and observational cohort study of MBS performed between May 01, 2020, and October 10,2020, in 68 centres from 24 countries. Data collection included in-hospital and 30-day COVID-19 and surgery-specific morbidity/mortality. Results: One hundred and seventy adolescent patients (mean age: 17.75 ± 1.30 years), mostly females (n=122, 71.8%), underwent MBS during the study period. The mean pre-operative weight and body mass index were 122.16 ± 15.92 kg and 43.7± 7.11 kg/m2, respectively. Although majority of patients had pre-operative testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n=146; 85.9%), only 42.4% (n=72) of the patients were asked to self-isolate pre-operatively. Two patients developed symptomatic SARS-CoV-2 infection post-operatively (1.2%). The overall complication rate was 5.3% (n=9). There was no mortality in this cohort. Conclusions: MBS in adolescents with obesity is safe during the COVID-19 pandemic when performed within the context of local precautionary procedures (such as pre-operative testing). The 30-day morbidity rates were similar to those reported pre-pandemic. These data will help facilitate the safe re-introduction of MBS services for this group of patients.
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- 2021
28. Machine learning from quantitative coronary computed tomography angiography predicts ischemia and impaired myocardial blood flow
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Lin, A, primary, Van Diemen, P, additional, Motwani, M, additional, McElhinney, P, additional, Otaki, Y, additional, Han, D, additional, Kwan, A, additional, Tzolos, E, additional, Cadet, S, additional, Danad, I, additional, Driessen, R, additional, Slomka, P J, additional, Berman, D S, additional, Dey, D, additional, and Knaapen, P, additional
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- 2021
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29. P60.12 Prevalence of c-Met overexpression (c-Met+) and Impact of Prior Lines of Treatment on c-Met Protein Expression in NSCLC
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Motwani, M., primary, Panchabhai, S., additional, Bar, J., additional, Girard, N., additional, Bradbury, P., additional, Lu, S., additional, Jin, J., additional, Hotson, A., additional, Maag, D., additional, Planchard, D., additional, and Camidge, D.R., additional
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- 2021
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30. P47.03 Telisotuzumab Vedotin Monotherapy in Patients With Previously Treated c-Met+ Advanced Non-Small Cell Lung Cancer: Stage 2
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Goldman, J., primary, Moiseenko, F., additional, Cicin, I., additional, Horinouchi, H., additional, Filippova, E., additional, Bar, J., additional, Lu, S., additional, Tomasini, P., additional, Ocampo, C., additional, Sullivan, D., additional, Maag, D., additional, Motwani, M., additional, Jin, J., additional, and Camidge, D.R., additional
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- 2021
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31. 30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data
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Singhal, R. Cardoso, V.R. Wiggins, T. Super, J. Ludwig, C. Gkoutos, G.V. Mahawar, K. Pędziwiatr, M. Major, P. Zarzycki, P. Pantelis, A. Lapatsanis, D.P. Stravodimos, G. Matthys, C. Focquet, M. Vleeschouwers, W. Spaventa, A.G. Zerrweck, C. Vitiello, A. Berardi, G. Musella, M. Sanchez-Meza, A. Cantu, F.J., Jr Mora, F. Cantu, M.A. Katakwar, A. Reddy, D.N. Elmaleh, H. Hassan, M. Elghandour, A. Elbanna, M. Osman, A. Khan, A. layani, L. Kiran, N. Velikorechin, A. Solovyeva, M. Melali, H. Shahabi, S. Agrawal, A. Shrivastava, A. Sharma, A. Narwaria, B. Narwaria, M. Raziel, A. Sakran, N. Susmallian, S. Karagöz, L. Akbaba, M. Pişkin, S.Z. Balta, A.Z. Senol, Z. Manno, E. Iovino, M.G. Osman, A. Qassem, M. Arana-Garza, S. Povoas, H.P. Vilas-Boas, M.L. Naumann, D. Li, A. Ammori, B.J. Balamoun, H. Salman, M. Nasta, A.M. Goel, R. Sánchez-Aguilar, H. Herrera, M.F. Abou-mrad, A. Cloix, L. Mazzini, G.S. Kristem, L. Lazaro, A. Campos, J. Bernardo, J. González, J. Trindade, C. Viveiros, O. Ribeiro, R. Goitein, D. Hazzan, D. Segev, L. Beck, T. Reyes, H. Monterrubio, J. García, P. Benois, M. Kassir, R. Contine, A. Elshafei, M. Aktas, S. Weiner, S. Heidsieck, T. Level, L. Pinango, S. Ortega, P.M. Moncada, R. Valenti, V. Vlahović, I. Boras, Z. Liagre, A. Martini, F. Juglard, G. Motwani, M. Saggu, S.S. Momani, H.A. López, L.A.A. Cortez, M.A.C. Zavala, R.A. D’Haese RN, C. Kempeneers, I. Himpens, J. Lazzati, A. Paolino, L. Bathaei, S. Bedirli, A. Yavuz, A. Büyükkasap, Ç. Özaydın, S. Kwiatkowski, A. Bartosiak, K. Walędziak, M. Santonicola, A. Angrisani, L. Iovino, P. Palma, R. Iossa, A. Boru, C.E. De Angelis, F. Silecchia, G. Hussain, A. Balchandra, S. Coltell, I.B. Pérez, J.L. Bohra, A. Awan, A.K. Madhok, B. Leeder, P.C. Awad, S. Al-Khyatt, W. Shoma, A. Elghadban, H. Ghareeb, S. Mathews, B. Kurian, M. Larentzakis, A. Vrakopoulou, G.Z. Albanopoulos, K. Bozdag, A. Lale, A. Kirkil, C. Dincer, M. Bashir, A. Haddad, A. Hijleh, L.A. Zilberstein, B. de Marchi, D.D. Souza, W.P. Brodén, C.M. Gislason, H. Shah, K. Ambrosi, A. Pavone, G. Tartaglia, N. Kona, S.L.K. Kalyan, K. Perez, C.E.G. Botero, M.A.F. Covic, A. Timofte, D. Maxim, M. Faraj, D. Tseng, L. Liem, R. Ören, G. Dilektasli, E. Yalcin, I. AlMukhtar, H. Hadad, M.A. Mohan, R. Arora, N. Bedi, D. Rives-Lange, C. Chevallier, J.-M. Poghosyan, T. Sebbag, H. Zinaï, L. Khaldi, S. Mauchien, C. Mazza, D. Dinescu, G. Rea, B. Pérez-Galaz, F. Zavala, L. Besa, A. Curell, A. Balibrea, J.M. Vaz, C. Galindo, L. Silva, N. Caballero, J.L.E. Sebastian, S.O. Marchesini, J.C.D. da Fonseca Pereira, R.A. Sobottka, W.H. Fiolo, F.E. Turchi, M. Coelho, A.C.J. Zacaron, A.L. Barbosa, A. Quinino, R. Menaldi, G. Paleari, N. Martinez-Duartez, P. de Esparza, G.M.A.R. Esteban, V.S. Torres, A. Garcia-Galocha, J.L. Josa, M. Pacheco-Garcia, J.M. Mayo-Ossorio, M.A. Chowbey, P. Soni, V. de Vasconcelos Cunha, H.A. Castilho, M.V. Ferreira, R.M.A. Barreiro, T.A. Charalabopoulos, A. Sdralis, E. Davakis, S. Bomans, B. Dapri, G. Van Belle, K. Takieddine, M. Vaneukem, P. Karaca, E.S.A. Karaca, F.C. Sumer, A. Peksen, C. Savas, O.A. Chousleb, E. Elmokayed, F. Fakhereldin, I. Aboshanab, H.M. Swelium, T. Gudal, A. Gamloo, L. Ugale, A. Ugale, S. Boeker, C. Reetz, C. Hakami, I.A. Mall, J. Alexandrou, A. Baili, E. Bodnar, Z. Maleckas, A. Gudaityte, R. Guldogan, C.E. Gundogdu, E. Ozmen, M.M. Thakkar, D. Dukkipati, N. Shah, P.S. Shah, S.S. Shah, S.S. Adil, M.T. Jambulingam, P. Mamidanna, R. Whitelaw, D. Adil, M.T. Jain, V. Veetil, D.K. Wadhawan, R. Torres, A. Torres, M. Tinoco, T. Leclercq, W. Romeijn, M. van de Pas, K. Alkhazraji, A.K. Taha, S.A. Ustun, M. Yigit, T. Inam, A. Burhanulhaq, M. Pazouki, A. Eghbali, F. Kermansaravi, M. Jazi, A.H.D. Mahmoudieh, M. Mogharehabed, N. Tsiotos, G. Stamou, K. Rodriguez, F.J.B. Navarro, M.A.R. Torres, O.M. Martinez, S.L. Tamez, E.R.M. Cornejo, G.A.M. Flores, J.E.G. Mohammed, D.A. Elfawal, M.H. Shabbir, A. Guowei, K. So, J.B. Kaplan, E.T. Kaplan, M. Kaplan, T. Pham, D.T. Rana, G. Kappus, M. Gadani, R. Kahitan, M. Pokharel, K. Osborne, A. Pournaras, D. Hewes, J. Napolitano, E. Chiappetta, S. Bottino, V. Dorado, E. Schoettler, A. Gaertner, D. Fedtke, K. Aguilar-Espinosa, F. Aceves-Lozano, S. Balani, A. Nagliati, C. Pennisi, D. Rizzi, A. Frattini, F. Foschi, D. Benuzzi, L. Parikh, C. Shah, H. Pinotti, E. Montuori, M. Borrelli, V. Dargent, J. Copaescu, C.A. Hutopila, I. Smeu, B. Witteman, B. Hazebroek, E. Deden, L. Heusschen, L. Okkema, S. Aufenacker, T. den Hengst, W. Vening, W. van der Burgh, Y. Ghazal, A. Ibrahim, H. Niazi, M. Alkhaffaf, B. Altarawni, M. Cesana, G.C. Anselmino, M. Uccelli, M. Olmi, S. Stier, C. Akmanlar, T. Sonnenberg, T. Schieferbein, U. Marcolini, A. Awruch, D. Vicentin, M. de Souza Bastos, E.L. Gregorio, S.A. Ahuja, A. Mittal, T. Bolckmans, R. Wiggins, T. Baratte, C. Wisnewsky, J.A. Genser, L. Chong, L. Taylor, L. Ward, S. Hi, M.W. Heneghan, H. Fearon, N. Plamper, A. Rheinwalt, K. Heneghan, H. Geoghegan, J. Ng, K.C. Fearon, N. Kaseja, K. Kotowski, M. Samarkandy, T.A. Leyva-Alvizo, A. Corzo-Culebro, L. Wang, C. Yang, W. Dong, Z. Riera, M. Jain, R. Hamed, H. Said, M. Zarzar, K. Garcia, M. Türkçapar, A.G. Şen, O. Baldini, E. Conti, L. Wietzycoski, C. Lopes, E. Pintar, T. Salobir, J. Aydin, C. Atici, S.D. Ergin, A. Ciyiltepe, H. Bozkurt, M.A. Kizilkaya, M.C. Onalan, N.B.D. Zuber, M.N.B.A. Wong, W.J. Garcia, A. Vidal, L. Beisani, M. Pasquier, J. Vilallonga, R. Sharma, S. Parmar, C. Lee, L. Sufi, P. Sinan, H. Saydam, M. GENEVA Collaborators
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nutritional and metabolic diseases - Abstract
Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts. © 2021, The Author(s).
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- 2021
32. P323Triage-HF Plus: identification of heart failure and non-heart failure events in an ambulatory population using remote monitoring and the triage heart failure risk score Algorithm
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Ahmed, F, primary, Taylor, J, additional, Green, C, additional, Wickwar, L, additional, Zaidi, A, additional, Cunnington, C, additional, and Motwani, M, additional
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- 2020
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33. P2.01-19 Phase 2 Study of Telisotuzumab Vedotin (Teliso-V) in Previously Treated c-MET+ Non-Small Cell Lung Cancer: Trial in Progress
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Ocampo, C., primary, Wu, J., additional, Dey, J., additional, Sun, Z., additional, Motwani, M., additional, Reddy, A., additional, Parikh, A., additional, Hay, J., additional, Komarnitsky, P., additional, and Bach, B., additional
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- 2019
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34. First-in-human study of ABBV-621 in patients (pts) with previously treated sold tumours: Dose-optimization cohorts
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Calvo, E., primary, de Jonge, M.J.A., additional, Rasco, D.W., additional, Moreno, V., additional, Chang, Y.-W., additional, Chiney, M., additional, Motwani, M., additional, Penugonda, S., additional, Petrich, A.M., additional, Ratain, M.J., additional, and LoRusso, P., additional
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- 2019
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35. MA14.03 EGFR M+ Subgroup of Phase 1b Study of Telisotuzumab Vedotin (Teliso-V) Plus Erlotinib in c-Met+ Non-Small Cell Lung Cancer
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Camidge, D.R., primary, Barlesi, F., additional, Goldman, J., additional, Morgensztern, D., additional, Heist, R., additional, Vokes, E., additional, Spira, A., additional, Angevin, E., additional, Su, W., additional, Hong, D., additional, Strickler, J., additional, Motwani, M., additional, Sun, Z., additional, Parikh, A., additional, Komarnitsky, P., additional, Wu, J., additional, and Kelly, K., additional
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- 2019
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36. Circulating tumour DNA (ctDNA) analysis in patients (pts) with non-small cell lung cancer (NSCLC) treated with telisotuzumab vedotin (teliso-v), an antibody-drug conjugate targeting c-Met
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Heist, R.S., primary, Motwani, M., additional, Naumovski, L., additional, Wu, J., additional, Bach, B.A., additional, Lu, X., additional, and Kelly, K., additional
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- 2019
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37. P124Sequential CT coronary angiography and 82-Rb positron emission tomography: Defining the quantitative relationships between coronary artery calcium, coronary stenosis and myocardial blood flow reserve
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Moody, W E, primary, Motwani, M, additional, and Arumugam, P, additional
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- 2019
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38. An open-label, multicenter, phase I study of ABBV-399 (telisotuzumab vedotin, teliso-V) as monotherapy (T) and in combination with erlotinib (T+E) in non-small cell lung cancer (NSCLC)
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Camidge, R., primary, Heist, R.S., additional, Goldman, J., additional, Angevin, E., additional, Strickler, J., additional, Morgensztern, D., additional, Barve, M., additional, Bauer, T.M., additional, Vokes, E.E., additional, Yi, T., additional, Motwani, M., additional, Parikh, A., additional, Wu, J., additional, and Kelly, K., additional
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- 2018
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39. Phase 1b open-label study evaluating the safety, pharmacokinetics, and preliminary efficacy of ABT-165 plus FOLFIRI in patients with second-line (2L) colorectal cancer (CRC)
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Wainberg, Z., primary, Strickler, J., additional, Gordon, M., additional, Barve, M., additional, Wang, L., additional, Yue, H., additional, Motwani, M., additional, Kasichayanula, S., additional, Naumovski, L., additional, and Hamilton, E., additional
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- 2018
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40. ABT-165 plus FOLFIRI vs bevacizumab plus FOLFIRI in patients with metastatic colorectal cancer (mCRC) previously treated with fluoropyrimidine/oxaliplatin and bevacizumab - Trial in progress
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Wainberg, Z., primary, Wang, L., additional, Yue, H., additional, Motwani, M., additional, Kasichayanula, S., additional, Blaney, M., additional, Naumovski, L., additional, and Strickler, J., additional
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- 2018
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41. MA 02.10 Phase I Study of ABBV-399 (Telisotuzumab Vedotin) as Monotherapy and in Combination with Erlotinib in NSCLC
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Goldman, J., primary, Angevin, E., additional, Strickler, J., additional, Camidge, D.R., additional, Heist, R., additional, Morgensztern, D., additional, Barve, M., additional, Yue, H., additional, Beaulieu, J., additional, Motwani, M., additional, Afar, D., additional, Naumovski, L., additional, and Kelly, K., additional
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- 2017
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42. P1.04-006 Rovalpituzumab Tesirine vs Topotecan in Patients with Advanced Small Cell Lung Cancer Following 1st Line Chemotherapy
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Komarnitsky, P., primary, Lee, H., additional, Shah, M., additional, Wong, S., additional, Gulbranson, S., additional, Dziubinski, J., additional, Caffrey, L., additional, Tanwani, P., additional, Motwani, M., additional, and Zhang, F., additional
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- 2017
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43. Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease
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Motwani, M. (Manish), Dey, D. (Damini), Berman, D.S. (Daniel), Germano, G. (Guido), Achenbach, S. (Stephan), Al-Mallah, M. (Mouaz), Andreini, D. (Daniele), Budoff, M.J. (Matthew), Cademartiri, F. (Filippo), Callister, T.Q. (Tracy), Chang, H.-J. (Hyuk-Jae), Chinnaiyan, K. (Kavitha), Chow, B.J.W. (Benjamin), Cury, R.C. (Ricardo), Delago, A. (Augustin), Gomez, M. (Millie), Gransar, H. (Heidi), Hadamitzky, M. (Martin), Hausleiter, J. (Jörg), Hindoyan, N. (Niree), Feuchtner, G.M. (Gudrun), Kaufmann, P.A. (Philipp), Kim, Y.-J. (Yong-Jin), Leipsic, J. (Jonathon), Lin, F.Y. (Fay), Maffei, E. (Erica), Marques, H. (Hugo), Pontone, G. (Gianluca), Raff, G.L. (Gilbert), Rubinshtein, R. (Ronen), Shaw, L.J. (Leslee), Stehli, J. (Julia), Villines, T.C. (Todd), Dunning, A.M. (Alison), Min, J.K. (James), Slomka, P.J. (Piotr J.), Motwani, M. (Manish), Dey, D. (Damini), Berman, D.S. (Daniel), Germano, G. (Guido), Achenbach, S. (Stephan), Al-Mallah, M. (Mouaz), Andreini, D. (Daniele), Budoff, M.J. (Matthew), Cademartiri, F. (Filippo), Callister, T.Q. (Tracy), Chang, H.-J. (Hyuk-Jae), Chinnaiyan, K. (Kavitha), Chow, B.J.W. (Benjamin), Cury, R.C. (Ricardo), Delago, A. (Augustin), Gomez, M. (Millie), Gransar, H. (Heidi), Hadamitzky, M. (Martin), Hausleiter, J. (Jörg), Hindoyan, N. (Niree), Feuchtner, G.M. (Gudrun), Kaufmann, P.A. (Philipp), Kim, Y.-J. (Yong-Jin), Leipsic, J. (Jonathon), Lin, F.Y. (Fay), Maffei, E. (Erica), Marques, H. (Hugo), Pontone, G. (Gianluca), Raff, G.L. (Gilbert), Rubinshtein, R. (Ronen), Shaw, L.J. (Leslee), Stehli, J. (Julia), Villines, T.C. (Todd), Dunning, A.M. (Alison), Min, J.K. (James), and Slomka, P.J. (Piotr J.)
- Abstract
__Aims__ Traditional prognostic risk assessment in patients undergoing non-invasive imaging is based upon a limited selection of clinical and imaging findings. Machine learning (ML) can consider a greater number and complexity of variables. Therefore, we investigated the feasibility and accuracy of ML to predict 5-year all-cause mortality (ACM) in patients undergoing coronary computed tomographic angiography (CCTA), and compared the performance to existing clinical or CCTA metrics. __Methods and results__ The analysis included 10 030 patients with suspected coronary artery disease and 5-year follow-up from the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry. All patients underwent CCTA as their standard of care. Twenty-five clinical and 44 CCTA parameters were evaluated, including segment stenosis score (SSS), segment involvement score (SIS), modified Duke index (DI), number of segments with non-calcified, mixed or calcified plaques, age, sex, gender, standard cardiovascular risk factors, and Framingham risk score (FRS). Machine learning involved automated feature selection by information gain ranking, model building with a boosted ensemble algorithm, and 10-fold stratified cross-validation. Seven hundred and forty-five patients died during 5-year follow-up. Machine learning exhibited a higher area-under-curve compared with the FRS or CCTA severity scores alone (SSS, SIS, DI) for predicting all-cause mortality (ML: 0.79 vs. FRS: 0.61, SSS: 0.64, SIS: 0.64, DI: 0.62; P , 0.001). __Conclusions__ Machine learning combining clinical and CCTA data was found to predict 5-year ACM significantly better than existing clinical or CCTA metrics alone.
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- 2017
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44. 84Single-centre experience of cied lead extraction using cook medical evolution system
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Zaidi, A, primary, Ali, M, additional, Cunnington, C, additional, Motwani, M, additional, Allen, S, additional, and Ahmed, FZ, additional
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- 2017
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45. 22Cied lead extraction in the elderly has low risk
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Zaidi, A, primary, Ali, M, additional, Cunnington, C, additional, Motwani, M, additional, Allen, S, additional, and Ahmed, FZ, additional
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- 2017
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46. A phase 3 trial of rovalpituzumab tesirine vs topotecan in patients with advanced small cell lung cancer following frontline platinum-based chemotherapy
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Komarnitsky, P., primary, Lee, H-J., additional, Shah, M., additional, Wong, S., additional, Gulbranson, S., additional, Dziubinski, J., additional, Caffrey, L., additional, Tanwani, P., additional, Motwani, M., additional, and Zhang, F., additional
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- 2017
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47. Myocardial Extracellular Volume Estimation by CMR Predicts Functional Recovery Following Acute MI
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Kidambi, A, Motwani, M, Uddin, A, Ripley, DP, McDiarmid, AK, Swoboda, PP, Broadbent, DA, Al Musa, T, Erhayiem, B, Leader, J, Croisille, P, Clarysse, P, Greenwood, JP, Plein, S, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,Time Factors ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,CT and MRI ,Myocardial Infarction ,acute myocardial infarction ,Contrast Media ,Magnetic Resonance Imaging, Cine ,Ventricular Function, Left ,AUC, area under the curve ,Percutaneous Coronary Intervention ,CMR, cardiac magnetic resonance ,contractile function ,Predictive Value of Tests ,MO, microvascular obstruction ,EF, ejection fraction ,Humans ,cardiovascular diseases ,Prospective Studies ,Original Research ,Aged ,LGE, late gadolinium enhancement ,Myocardium ,LV, left ventricle/ventricular ,Reproducibility of Results ,ECV, extracellular volume ,Recovery of Function ,Middle Aged ,MOLLI, modified Look-Locker inversion ,Myocardial Contraction ,AMI, acute myocardial infarction ,Treatment Outcome ,ROC Curve ,Radiology Nuclear Medicine and imaging ,Area Under Curve ,Multivariate Analysis ,cardiovascular system ,Linear Models ,cardiovascular imaging agents/techniques ,ST Elevation Myocardial Infarction ,Female ,Cardiology and Cardiovascular Medicine ,Biomarkers - Abstract
Objectives In the setting of reperfused acute myocardial infarction (AMI), the authors sought to compare prediction of contractile recovery by infarct extracellular volume (ECV), as measured by T1-mapping cardiac magnetic resonance (CMR), with late gadolinium enhancement (LGE) transmural extent. Background The transmural extent of myocardial infarction as assessed by LGE CMR is a strong predictor of functional recovery, but accuracy of the technique may be reduced in AMI. ECV mapping by CMR can provide a continuous measure associated with the severity of tissue damage within infarcted myocardium. Methods Thirty-nine patients underwent acute (day 2) and convalescent (3 months) CMR scans following AMI. Cine imaging, tissue tagging, T2-weighted imaging, modified Look-Locker inversion T1 mapping natively and 15 min post–gadolinium-contrast administration, and LGE imaging were performed. The ability of acute infarct ECV and acute transmural extent of LGE to predict convalescent wall motion, ejection fraction (EF), and strain were compared per-segment and per-patient. Results Per-segment, acute ECV and LGE transmural extent were associated with convalescent wall motion score (p, Graphical abstract
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- 2015
48. Early diagnosis of cardiac implantable electronic device generator pocket infection using F-18-FDG-PET/CT
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Ahmed, FZ, James, J, Cunnington, C, Motwani, M, Fullwood, C, Hooper, J, Burns, P, Qamruddin, A, Al-Bahrani, G, Armstrong, I, Tout, D, Clarke, B, Sandoe, JAT, Arumugam, P, Mamas, MA, and Zaidi, AM
- Abstract
Aims: To examine the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the early diagnosis of cardiac implantable electronic device (CIED) generator pocket infection. Methods and results: A total of 86 patients with CIEDs were evaluated with 18F-FDG PET/CT imaging: 46 with suspected generator pocket infection and 40 without any history of infection. 18F-FDG activity in the region of the generator pocket was expressed as a semi-quantitative ratio (SQR)—defined as the maximum count rate around the CIED divided by the mean count rate between normal right and left lung parenchyma. All patients underwent standard clinical management, independent of the PET/CT result. Patients with suspected generator pocket infection that required CIED extraction (n = 32) had significantly higher 18F-FDG activity compared with those that did not (n = 14), and compared with controls (n = 40) [SQR: 4.80 (3.18–7.05) vs. 1.40 (0.88–1.73) vs. 1.10 (0.98–1.40), respectively; P < 0.001]. On receiver operator characteristic analysis, SQR had a high diagnostic accuracy (area under curve = 0.98) for the early identification of patients with confirmed infection (i.e. those ultimately needing extraction)—with an optimal SQR cut-off value of >2.0 (sensitivity = 97%; specificity = 98%). Conclusion: This study highlights the potential benefits of evaluating patients with suspected CIED generator pocket infection using 18F-FDG PET/CT. In this study, 18F-FDG PET/CT had a high diagnostic accuracy in the early diagnosis of CIED generator pocket infection, even where initial clinical signs were underwhelming.
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- 2015
49. 1469P - Circulating tumour DNA (ctDNA) analysis in patients (pts) with non-small cell lung cancer (NSCLC) treated with telisotuzumab vedotin (teliso-v), an antibody-drug conjugate targeting c-Met
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Heist, R.S., Motwani, M., Naumovski, L., Wu, J., Bach, B.A., Lu, X., and Kelly, K.
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- 2019
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50. 457P - First-in-human study of ABBV-621 in patients (pts) with previously treated sold tumours: Dose-optimization cohorts
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Calvo, E., de Jonge, M.J.A., Rasco, D.W., Moreno, V., Chang, Y.-W., Chiney, M., Motwani, M., Penugonda, S., Petrich, A.M., Ratain, M.J., and LoRusso, P.
- Published
- 2019
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