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The use of the Pringle maneuver (PM) varies widely among surgical departments. Its use depends on the operator and type of liver resection. The aim of this study was to determine the impact of the PM on patient outcomes when undergoing major liver resections. This retrospective study comprised 179 colorectal liver metastasis patients from two liver centers from Leeds and Warsaw. Only right or right extended hepatectomies with negative oncological margins were included. The primary outcome measure was the 5-year overall survival (OS). The PM was applied during 60 (33.5%) major hepatectomies included in the study and was associated with a higher peak 3-day postoperative bilirubin concentration (p = 0.002), yet not with the peak 3-day alanine aminotransferase activity (p = 0.415). The 5-year OS after liver resections with the PM and without the PM were 55.0% and 33.4%, respectively (p = 0.019). Following stratification by the Tumor Burden Score, after resections with the use of the PM, superior survival was particularly found in the subgroup of patients at intermediate risk of recurrence (p = 0.004). However, the use of the PM had no significant effect on the 5-year overall survival following adjustment for the confounding effect of the carcinoembryonic antigen concentration (p = 0.265). The use of the PM had no negative effects on the long-term outcomes in patients undergoing major, oncologically radical liver resections for colorectal metastases.

[ES] Este proyecto está en el área de automática. Más precisamente, en el campo de PLC y control industrial. Específicamente, el programa automático que controla una planta embotelladora de cerveza ha sido diseñado e implementado. El objetivo de este software de control es gestionar el flujo de botellas a lo largo de la línea de producción, así como mantener abastecidas todas las máquinas involucradas en el proceso de llenado con cerveza, etiquetado y colocación de tapas en botellas. SCADA (Supervisión, Control y Adquisición de Datos) se ha utilizado. Esto significa que el software de control también tiene una amigable HMI (Interfaz Humano-Máquina) que permite a su usuario no solo conocer el estado de cada parte de la planta sino también cambiar los diferentes parámetros de las máquinas que trabajan en la línea de producción . El software de control y HMI han sido diseñados utilizando el software Proficy Machine Edition para funcionar en un panel de pantalla táctil fabricado por General Electric. Además, se ha diseñado e implementado una simulación de la planta de embotellado en el programa Arena para que se puedan probar todas las partes del programa de control. A partir de esta simulación, podemos sacar algunas conclusiones interesantes sobre el tiempo medio que lleva producir una botella de cerveza y la influencia de diferentes parámetros tales como las velocidades de los carros transportadores o la velocidad del las cintas de la linea de producción., [EN] This project is in the area of automatics. More precisely, in the field of PLC and industrial control. Specifically, the automatic program that controls a beer bottling plant has been designed and implemented. The aim of this control software is to manage bottles flow along the production line as well as keeping stocked all the machines involved in the process of filling with beer, labelling and putting caps to bottles. SCADA (Supervisory Control And Data Acquisition) has been used. This means that the control software has also a friendly Human Machine InterfaceHMI (Human Machine Interface) that allows its user not only to be updated about the state of each part of the plant but also to change different parameters of the machines working in the production line. The control software and the Human Machine InterfaceHMI have been designed using Proficy Machine Edition software in order to work in a touch screen panel made by General Electric. Also, a simulation of the bottling plant has been designed and implemented in the Arena Software so that all the parts of the control program can be tested. From this simulation, we can take some interesting conclusions about the mean time that takes to produce a bottle of beer and the influence of different parameters such as carts speeds or conveyor speeds on this time.