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1. Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques

Author

Kaiser, Jaclyn A., Nelson, Christine E., Liu, Xueqiao, Park, Hong-Su, Matsuoka, Yumiko, Luongo, Cindy, Santos, Celia, Ahlers, Laura R. H., Herbert, Richard, Moore, Ian N., Wilder-Kofie, Temeri, Moore, Rashida, Walker, April, Yang, Lijuan, Munir, Shirin, Teng, I-Ting, Kwong, Peter D., Dowdell, Kennichi, Nguyen, Hanh, Kim, JungHyun, Cohen, Jeffrey I., Johnson, Reed F., Garza, Nicole L., Via, Laura E., Barber, Daniel L., Buchholz, Ursula J., and Le Nouën, Cyril

Published
2024
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4. Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine

Author

Li, Dapeng, Martinez, David R., Schäfer, Alexandra, Chen, Haiyan, Barr, Maggie, Sutherland, Laura L., Lee, Esther, Parks, Robert, Mielke, Dieter, Edwards, Whitney, Newman, Amanda, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Gagne, Matthew, Douek, Daniel C., DeMarco, C. Todd, Denny, Thomas N., Oguin, III, Thomas H., Brown, Alecia, Rountree, Wes, Wang, Yunfei, Mansouri, Katayoun, Edwards, Robert J., Ferrari, Guido, Sempowski, Gregory D., Eaton, Amanda, Tang, Juanjie, Cain, Derek W., Santra, Sampa, Pardi, Norbert, Weissman, Drew, Tomai, Mark A., Fox, Christopher B., Moore, Ian N., Andersen, Hanne, Lewis, Mark G., Golding, Hana, Seder, Robert, Khurana, Surender, Baric, Ralph S., Montefiori, David C., Saunders, Kevin O., and Haynes, Barton F.

Published
2022
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8. A nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion.

Author

Wang, Kening, Jordan, Tristan, Dowdell, Kennichi, Herbert, Richard, Moore, Ian N., Koelle, David M., and Cohen, Jeffrey I.

Subjects
HUMAN herpesvirus 2, HERPES genitalis, RHESUS monkeys, VACCINE effectiveness, VIRAL shedding, VIRAL antibodies
Abstract

The most commonly used animal models for evaluating the efficacy of HSV-2 candidate vaccines are mice and guinea pigs. While numerous HSV-2 vaccine candidates have been tested in these animals and were effective in reducing disease and mortality, these results did not predict the effectiveness of the vaccines in human trials. Infection of rhesus macaques rarely results in lesions or HSV-2 specific antibody responses. In seeking an animal model that better recapitulates human disease and that might be more predictive of the efficacy of prophylactic vaccines than mice and guinea pigs, we evaluated Cebus apella (C. apella), a New World primate, in an HSV-2 genital infection model. Infectious HSV-2 was cultured from vaginal swabs from all 4 animals for 9–14 days after intravaginal inoculation of HSV-2 seronegative monkeys. Two of 4 monkeys had vesicular lesions in the vagina or vulva. No neurological symptoms were noted. Recurrent lesions and HSV-2 DNA shedding after acute disease resolved was infrequent. UV irradiation of the genital area did not induce recurrent genital lesions or virus shedding. All 4 monkeys developed HSV-2 neutralizing antibodies as well as virus-specific CD4 and CD8 T cell responses. Reinfection of animals 15 to 19 months after primary infection did not result in lesions; animals had reduced virus shedding and a shorter duration of shedding compared with that during primary infection, suggesting that primary infection induced protective immunity. Primary fibroblasts from C. apella monkeys supported the growth of HSV-2 in vitro; in contrast, HSV-2 did not replicate above the titer of the input inoculum in fibroblasts from rhesus macaques. These observations suggest that the C. apella monkey has potential to serve as a model for evaluating the efficacy of prophylactic vaccines, antivirals, or monoclonal antibodies to HSV-2. Author summary: Herpes simplex virus 2 (HSV-2) is a cause of genital herpes, neonatal herpes, and herpes encephalitis. The virus persists in the nervous system for life and periodically reactivates resulting in recurrent genital lesions and can be transmitted to susceptible individuals. Currently there is no cure for the disease and no licensed vaccine to prevent infection. Numerous HSV-2 vaccine candidates have been tested in animal models, mostly in mice and guinea pigs, and vaccine efficacy observed in these animals has been poorly predictive for effectiveness of HSV-2 vaccines in humans. Thus, there is a need for an animal model that better recapitulates human disease and is more predictive for the efficacy of prophylactic vaccines. We evaluated an HSV-2 genital infection model using Cebus apella, a New World primate. Infectious HSV-2 was cultured from vaginal swabs from all 4 animals for 9–14 days after intravaginal inoculation. The animals developed symptoms similar to most humans with genital vesicular lesions and no neurological signs. They also developed antibody and T cell responses to HSV-2. Prior infection generally reduced reinfection. These observations suggest that Cebus apella monkeys have the potential to serve as a good model for evaluating the efficacy of prophylactic HSV-2 vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Author

Saunders, Kevin O., Lee, Esther, Parks, Robert, Martinez, David R., Li, Dapeng, Chen, Haiyan, Edwards, Robert J., Gobeil, Sophie, Barr, Maggie, Mansouri, Katayoun, Alam, S. Munir, Sutherland, Laura L., Cai, Fangping, Sanzone, Aja M., Berry, Madison, Manne, Kartik, Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Kapingidza, Anyway B., Azoitei, Mihai, Tse, Longping V., Scobey, Trevor D., Spreng, Rachel L., Rountree, R. Wes, DeMarco, C. Todd, Denny, Thomas N., Woods, Christopher W., Petzold, Elizabeth W., Tang, Juanjie, Oguin, III, Thomas H., Sempowski, Gregory D., Gagne, Matthew, Douek, Daniel C., Tomai, Mark A., Fox, Christopher B., Seder, Robert, Wiehe, Kevin, Weissman, Drew, Pardi, Norbert, Golding, Hana, Khurana, Surender, Acharya, Priyamvada, Andersen, Hanne, Lewis, Mark G., Moore, Ian N., Montefiori, David C., Baric, Ralph S., and Haynes, Barton F.

Published
2021
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11. Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Author

Yang, Chunfu, Lei, Lei, Collins, John W. Marshall, Briones, Michael, Ma, Li, Sturdevant, Gail L., Su, Hua, Kashyap, Anuj K., Dorward, David, Bock, Kevin W., Moore, Ian N., Bonner, Christine, Chen, Chih-Yu, Martens, Craig A., Ricklefs, Stacy, Yamamoto, Masahiro, Takeda, Kiyoshi, Iwakura, Yoichiro, McClarty, Grant, and Caldwell, Harlan D.

Published
2021
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12. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Author

Corbett, Kizzmekia S., Edwards, Darin K., Leist, Sarah R., Abiona, Olubukola M., Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A., Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T., DiPiazza, Anthony T., Dinnon, Kenneth H., Elbashir, Sayda M., Shaw, Christine A., Woods, Angela, Fritch, Ethan J., Martinez, David R., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Hutchinson, Geoffrey B., Wu, Kai, Henry, Carole, Bahl, Kapil, Garcia-Dominguez, Dario, Ma, LingZhi, Renzi, Isabella, Kong, Wing-Pui, Schmidt, Stephen D., Wang, Lingshu, Zhang, Yi, Phung, Emily, Chang, Lauren A., Loomis, Rebecca J., Altaras, Nedim Emil, Narayanan, Elisabeth, Metkar, Mihir, Presnyak, Vlad, Liu, Cuiping, Louder, Mark K., Shi, Wei, Leung, Kwanyee, Yang, Eun Sung, West, Ande, Gully, Kendra L., Stevens, Laura J., Wang, Nianshuang, Wrapp, Daniel, Doria-Rose, Nicole A., Stewart-Jones, Guillaume, Bennett, Hamilton, Alvarado, Gabriela S., Nason, Martha C., Ruckwardt, Tracy J., McLellan, Jason S., Denison, Mark R., Chappell, James D., Moore, Ian N., Morabito, Kaitlyn M., Mascola, John R., Baric, Ralph S., Carfi, Andrea, and Graham, Barney S.

Published
2020
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13. Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses

Author

Maximova, Olga A., primary, Weller, Melodie L., additional, Krogmann, Tammy, additional, Sturdevant, Daniel E., additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Martens, Craig, additional, Wollenberg, Kurt, additional, Minai, Mahnaz, additional, Moore, Ian N., additional, Sauter, Craig S., additional, Barker, Juliet N., additional, Lipkin, W. Ian, additional, Seilhean, Danielle, additional, Nath, Avindra, additional, and Cohen, Jeffrey I., additional

Published
2023
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14. Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques

Author

Shin, Tae-Hoon, primary, Zhou, Yifan, additional, Lee, Byung-Chul, additional, Hong, So Gun, additional, Andrew, Shayne F., additional, Flynn, Barbara J., additional, Gagne, Matthew, additional, Todd, John-Paul M., additional, Moore, Ian N., additional, Cook, Anthony, additional, Lewis, Mark G., additional, Foulds, Kathryn E., additional, Seder, Robert A., additional, Douek, Daniel C., additional, Roederer, Mario, additional, and Dunbar, Cynthia E., additional

Published
2023
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15. Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters

Author

Liu, Xueqiao, primary, Park, Hong-Su, additional, Matsuoka, Yumiko, additional, Santos, Celia, additional, Yang, Lijuan, additional, Luongo, Cindy, additional, Moore, Ian N., additional, Johnson, Reed F., additional, Garza, Nicole L., additional, Zhang, Peng, additional, Lusso, Paolo, additional, Best, Sonja M., additional, Buchholz, Ursula J., additional, and Le Nouën, Cyril, additional

Published
2023
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16. Human norovirus targets enteroendocrine epithelial cells in the small intestine

Author

Green, Kim Y., Kaufman, Stuart S., Nagata, Bianca M., Chaimongkol, Natthawan, Kim, Daniel Y., Levenson, Eric A., Tin, Christine M., Yardley, Allison Behrle, Johnson, Jordan A., Barletta, Ana Beatriz F., Khan, Khalid M., Yazigi, Nada A., Subramanian, Sukanya, Moturi, Sangeetha R., Fishbein, Thomas M., Moore, Ian N., and Sosnovtsev, Stanislav V.

Published
2020
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17. Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection

Author

Meyer, Michelle, Wang, Yuan, Edwards, Darin, Smith, Gregory R., Rubenstein, Aliza B., Ramanathan, Palaniappan, Mire, Chad E., Pietzsch, Colette, Chen, Xi, Ge, Yongchao, Cheng, Wan Sze, Henry, Carole, Woods, Angela, Ma, LingZhi, Stewart-Jones, Guillaume B.E., Bock, Kevin W., Minai, Mahnaz, Nagata, Bianca M., Periasamy, Sivakumar, Shi, Pei-Yong, Graham, Barney S., Moore, Ian N., Ramos, Irene, Troyanskaya, Olga G., Zaslavsky, Elena, Carfi, Andrea, Sealfon, Stuart C., and Bukreyev, Alexander

Subjects
Immunological research, Lung diseases -- Models -- Development and progression -- Prevention, Immune response -- Research, Messenger RNA -- Health aspects -- Physiological aspects, Leukocytes -- Health aspects -- Physiological aspects, Hamsters -- Physiological aspects, Health care industry
Abstract

The mRNA-1273 vaccine is effective against SARS-CoV-2 and was granted emergency use authorization by the FDA. Clinical studies, however, cannot provide the controlled response to infection and complex immunological insight that are only possible with preclinical studies. Hamsters are the only model that reliably exhibits severe SARS-CoV-2 disease similar to that in hospitalized patients, making them pertinent for vaccine evaluation. We demonstrate that prime or prime-boost administration of mRNA-1273 in hamsters elicited robust neutralizing antibodies, ameliorated weight loss, suppressed SARS-CoV-2 replication in the airways, and better protected against disease at the highest prime-boost dose. Unlike in mice and nonhuman primates, low-level virus replication in mRNA-1273-vaccinated hamsters coincided with an anamnestic response. Single-cell RNA sequencing of lung tissue permitted high-resolution analysis that is not possible in vaccinated humans. mRNA-1273 prevented inflammatory cell infiltration and the reduction of lymphocyte proportions, but enabled antiviral responses conducive to lung homeostasis. Surprisingly, infection triggered transcriptome programs in some types of immune cells from vaccinated hamsters that were shared, albeit attenuated, with mock- vaccinated hamsters. Our results support the use of mRNA-1273 in a 2-dose schedule and provide insight into the potential responses within the lungs of vaccinated humans who are exposed to SARS-CoV-2., Introduction When the World Health Organization declared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a global pandemic in March 2020, phase I clinical trials on the most promising vaccine candidates [...]

Published
2021
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19. TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

Author

Myles, Ian A., Anderson, Erik D., Earland, Noah J., Zarember, Kol A., Sastalla, Inka, Williams, Kelli W., Gough, Portia, Moore, Ian N., Ganesan, Sundar, Fowler, Cedar J., Laurence, Arian, Garofalo, Mary, Kuhns, Douglas B., Kieh, Mark D., Saleem, Arhum, Welch, Pamela A., Darnell, Dirk A., Gallin, John I., Freeman, Alexandra F., Holland, Steven M., and Datta, Sandip K.

Subjects
Staphylococcus aureus -- Health aspects, Epithelial cells -- Research, Immune response -- Research, Immunoglobulin E -- Health aspects, Health care industry
Abstract

Autosomal dominant hyper IgE syndrome (AD-HIES), or Job's syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent Staphylococcus aureus skin abscesses are a defining feature of this syndrome. A widely held hypothesis that defects in peripheral Th17 differentiation confer this susceptibility has never been directly evaluated. To assess the cutaneous immune response in AD-HIES, we induced suction blisters in healthy volunteers (HVs) and patients with AD-HIES and then challenged the wound with lethally irradiated bacteria. We show that cutaneous production of IL-17A and IL-17F was normal in patients with AD-HIES. Overproduction of TNF- [alpha] differentiated the responses in ADHIES from HVs. This was associated with reduced IL-10 family signaling in blister- infiltrating cells and defective epithelial cell function. Mouse models of AD-HIES recapitulated these aberrant epithelial responses to S. aureus and involved defective epithelial-to-mesenchymal transition (EMT) rather than a failure of bacterial killing. Defective responses in mouse models of AD-HIES and primary keratinocyte cultures from patients with AD-HIES could be reversed by TNF-[alpha] blockade and by drugs with reported modulatory effects on EMT. Our results identify these as potential therapeutic approaches in patients with ADHIES suffering S. aureus infections., Introduction Autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job's syndrome, is a primary immune deficiency caused by dominant-negative loss-of-function mutations in the STAT3 gene. Recurrent Staphylococcus aureus skin [...]

Published
2018
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20. Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys

Author

Le Nouën, Cyril, primary, Nelson, Christine E., additional, Liu, Xueqiao, additional, Park, Hong-Su, additional, Matsuoka, Yumiko, additional, Luongo, Cindy, additional, Santos, Celia, additional, Yang, Lijuan, additional, Herbert, Richard, additional, Castens, Ashley, additional, Moore, Ian N., additional, Wilder-Kofie, Temeri, additional, Moore, Rashida, additional, Walker, April, additional, Zhang, Peng, additional, Lusso, Paolo, additional, Johnson, Reed F., additional, Garza, Nicole L., additional, Via, Laura E., additional, Munir, Shirin, additional, Barber, Daniel L., additional, and Buchholz, Ursula J., additional

Published
2022
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23. An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques

Author

Sui, Yongjun, primary, Li, Jianping, additional, Andersen, Hanne, additional, Zhang, Roushu, additional, Prabhu, Sunaina K, additional, Hoang, Tanya, additional, Venzon, David, additional, Cook, Anthony, additional, Brown, Renita, additional, Teow, Elyse, additional, Velasco, Jason, additional, Pessaint, Laurent, additional, Moore, Ian N, additional, Lagenaur, Laurel, additional, Talton, Jim, additional, Breed, Matthew W, additional, Kramer, Josh, additional, Bock, Kevin W, additional, Minai, Mahnaz, additional, Nagata, Bianca M, additional, Choo-Wosoba, Hyoyoung, additional, Lewis, Mark G, additional, Wang, Lai-Xi, additional, and Berzofsky, Jay A, additional

Published
2022
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24. mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

Author

Gagne, Matthew, primary, Moliva, Juan I., additional, Foulds, Kathryn E., additional, Andrew, Shayne F., additional, Flynn, Barbara J., additional, Werner, Anne P., additional, Wagner, Danielle A., additional, Teng, I-Ting, additional, Lin, Bob C., additional, Moore, Christopher, additional, Jean-Baptiste, Nazaire, additional, Carroll, Robin, additional, Foster, Stephanie L., additional, Patel, Mit, additional, Ellis, Madison, additional, Edara, Venkata-Viswanadh, additional, Maldonado, Nahara Vargas, additional, Minai, Mahnaz, additional, McCormick, Lauren, additional, Honeycutt, Christopher Cole, additional, Nagata, Bianca M., additional, Bock, Kevin W., additional, Dulan, Caitlyn N.M., additional, Cordon, Jamilet, additional, Flebbe, Dillon R., additional, Todd, John-Paul M., additional, McCarthy, Elizabeth, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Narvaez, Brandon, additional, Valentin, Daniel, additional, Cook, Anthony, additional, Dodson, Alan, additional, Steingrebe, Katelyn, additional, Nurmukhambetova, Saule T., additional, Godbole, Sucheta, additional, Henry, Amy R., additional, Laboune, Farida, additional, Roberts-Torres, Jesmine, additional, Lorang, Cynthia G., additional, Amin, Shivani, additional, Trost, Jessica, additional, Naisan, Mursal, additional, Basappa, Manjula, additional, Willis, Jacquelyn, additional, Wang, Lingshu, additional, Shi, Wei, additional, Doria-Rose, Nicole A., additional, Zhang, Yi, additional, Yang, Eun Sung, additional, Leung, Kwanyee, additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Olia, Adam S., additional, Liu, Cuiping, additional, Harris, Darcy R., additional, Chuang, Gwo-Yu, additional, Stewart-Jones, Guillaume, additional, Renzi, Isabella, additional, Lai, Yen-Ting, additional, Malinowski, Agata, additional, Wu, Kai, additional, Mascola, John R., additional, Carfi, Andrea, additional, Kwong, Peter D., additional, Edwards, Darin K., additional, Lewis, Mark G., additional, Andersen, Hanne, additional, Corbett, Kizzmekia S., additional, Nason, Martha C., additional, McDermott, Adrian B., additional, Suthar, Mehul S., additional, Moore, Ian N., additional, Roederer, Mario, additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, and Seder, Robert A., additional

Published
2022
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25. Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

Author

Gagne, Matthew, primary, Corbett, Kizzmekia S., additional, Flynn, Barbara J., additional, Foulds, Kathryn E., additional, Wagner, Danielle A., additional, Andrew, Shayne F., additional, Todd, John-Paul M., additional, Honeycutt, Christopher Cole, additional, McCormick, Lauren, additional, Nurmukhambetova, Saule T., additional, Davis-Gardner, Meredith E., additional, Pessaint, Laurent, additional, Bock, Kevin W., additional, Nagata, Bianca M., additional, Minai, Mahnaz, additional, Werner, Anne P., additional, Moliva, Juan I., additional, Tucker, Courtney, additional, Lorang, Cynthia G., additional, Zhao, Bingchun, additional, McCarthy, Elizabeth, additional, Cook, Anthony, additional, Dodson, Alan, additional, Teng, I-Ting, additional, Mudvari, Prakriti, additional, Roberts-Torres, Jesmine, additional, Laboune, Farida, additional, Wang, Lingshu, additional, Goode, Adrienne, additional, Kar, Swagata, additional, Boyoglu-Barnum, Seyhan, additional, Yang, Eun Sung, additional, Shi, Wei, additional, Ploquin, Aurélie, additional, Doria-Rose, Nicole, additional, Carfi, Andrea, additional, Mascola, John R., additional, Boritz, Eli A., additional, Edwards, Darin K., additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Suthar, Mehul S., additional, Graham, Barney S., additional, Roederer, Mario, additional, Moore, Ian N., additional, Nason, Martha C., additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, and Seder, Robert A., additional

Published
2022
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26. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

Author

Li, Dapeng, primary, Edwards, Robert J., additional, Manne, Kartik, additional, Martinez, David R., additional, Schäfer, Alexandra, additional, Alam, S. Munir, additional, Wiehe, Kevin, additional, Lu, Xiaozhi, additional, Parks, Robert, additional, Sutherland, Laura L., additional, Oguin, Thomas H., additional, McDanal, Charlene, additional, Perez, Lautaro G., additional, Mansouri, Katayoun, additional, Gobeil, Sophie M.C., additional, Janowska, Katarzyna, additional, Stalls, Victoria, additional, Kopp, Megan, additional, Cai, Fangping, additional, Lee, Esther, additional, Foulger, Andrew, additional, Hernandez, Giovanna E., additional, Sanzone, Aja, additional, Tilahun, Kedamawit, additional, Jiang, Chuancang, additional, Tse, Longping V., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Cronin, Kenneth, additional, Gee-Lai, Victoria, additional, Deyton, Margaret, additional, Barr, Maggie, additional, Von Holle, Tarra, additional, Macintyre, Andrew N., additional, Stover, Erica, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Scobey, Trevor D., additional, Rountree, Wes, additional, Wang, Yunfei, additional, Moody, M. Anthony, additional, Cain, Derek W., additional, DeMarco, C. Todd, additional, Denny, Thomas N., additional, Woods, Christopher W., additional, Petzold, Elizabeth W., additional, Schmidt, Aaron G., additional, Teng, I-Ting, additional, Zhou, Tongqing, additional, Kwong, Peter D., additional, Mascola, John R., additional, Graham, Barney S., additional, Moore, Ian N., additional, Seder, Robert, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Montefiori, David C., additional, Sempowski, Gregory D., additional, Baric, Ralph S., additional, Acharya, Priyamvada, additional, Haynes, Barton F., additional, and Saunders, Kevin O., additional

Published
2021
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27. COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge

Author

DiPiazza, Anthony T., primary, Leist, Sarah R., additional, Abiona, Olubukola M., additional, Moliva, Juan I., additional, Werner, Anne, additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Bock, Kevin W., additional, Phung, Emily, additional, Schäfer, Alexandra, additional, Dinnon, Kenneth H., additional, Chang, Lauren A., additional, Loomis, Rebecca J., additional, Boyoglu-Barnum, Seyhan, additional, Alvarado, Gabriela S., additional, Sullivan, Nancy J., additional, Edwards, Darin K., additional, Morabito, Kaitlyn M., additional, Mascola, John R., additional, Carfi, Andrea, additional, Corbett, Kizzmekia S., additional, Moore, Ian N., additional, Baric, Ralph S., additional, Graham, Barney S., additional, and Ruckwardt, Tracy J., additional

Published
2021
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28. Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

Author

Sui, Yongjun, primary, Li, Jianping, additional, Zhang, Roushu, additional, Prabhu, Sunaina Kiran, additional, Andersen, Hanne, additional, Venzon, David, additional, Cook, Anthony, additional, Brown, Renita, additional, Teow, Elyse, additional, Velasco, Jason, additional, Greenhouse, Jack, additional, Putman-Taylor, Tammy, additional, Campbell, Tracey-Ann, additional, Pessaint, Laurent, additional, Moore, Ian N., additional, Lagenaur, Laurel, additional, Talton, Jim, additional, Breed, Matthew W., additional, Kramer, Josh, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Lewis, Mark G., additional, Wang, Lai-Xi, additional, and Berzofsky, Jay A., additional

Published
2021
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29. Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

Author

Maximova, Olga A, primary, Sturdevant, Daniel E, additional, Kash, John C, additional, Kanakabandi, Kishore, additional, Xiao, Yongli, additional, Minai, Mahnaz, additional, Moore, Ian N, additional, Taubenberger, Jeff, additional, Martens, Craig, additional, Cohen, Jeffrey I, additional, and Pletnev, Alexander G, additional

Published
2021
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31. Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance

Author

DeSouza-Vieira, Thiago, primary, Iniguez, Eva, additional, Serafim, Tiago D., additional, de Castro, Waldionê, additional, Karmakar, Subir, additional, Disotuar, Maria M., additional, Cecilio, Pedro, additional, Lacsina, Joshua R., additional, Meneses, Claudio, additional, Nagata, Bianca M., additional, Cardoso, Silvia, additional, Sonenshine, Daniel E., additional, Moore, Ian N., additional, Borges, Valeria M., additional, Dey, Ranadhir, additional, Soares, Miguel P., additional, Nakhasi, Hira L., additional, Oliveira, Fabiano, additional, Valenzuela, Jesus G., additional, and Kamhawi, Shaden, additional

Published
2020
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32. Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans

Author

Chen, Zhaochun, primary, Engle, Ronald E., additional, Shen, Chen-Hsiang, additional, Zhao, Huaying, additional, Schuck, Peter W., additional, Danoff, Emily J., additional, Nguyen, Hanh, additional, Nishimura, Norihisa, additional, Bock, Kevin W., additional, Moore, Ian N., additional, Kwong, Peter D., additional, Purcell, Robert H., additional, Govindarajan, Sugantha, additional, and Farci, Patrizia, additional

Published
2020
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34. Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis

Author

Lewis, Michael D., primary, Paun, Andrea, additional, Romano, Audrey, additional, Langston, Harry, additional, Langner, Charlotte A., additional, Moore, Ian N., additional, Bock, Kevin W., additional, Francisco, Amanda Fortes, additional, Brenchley, Jason M., additional, and Sacks, David L., additional

Published
2020
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35. A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters.

Author

Xueqiao Liu, Luongo, Cindy, Yumiko Matsuoka, Park, Hong-Su, Santos, Celia, Lijuan Yang, Moore, Ian N., Afroz, Sharmin, Johnson, Reed F., Lafont, Bernard A. P., Martens, Craig, Best, Sonja M., Munster, Vincent J., Hollý, Jaroslav, Yewdell, Jonathan W., Nouën, Cyril Le, Munir, Shirin, and Buchholz, Ursula J.

Subjects
COVID-19 vaccines, HAMSTERS, PARAINFLUENZA viruses, SARS-CoV-2, VACCINATION of children, COMMERCIAL products
Abstract

Single-dose vaccines with the ability to restrict SARS-CoV-2 replication in the respiratory tract are needed for all age groups, aiding efforts toward control of COVID-19. We developed a live intranasal vector vaccine for infants and children against COVID-19 based on replication-competent chimeric bovine/human parainfluenza virus type 3 (B/HPIV3) that express the native (S) or prefusionstabilized (S-2P) SARS-CoV-2 S spike protein, the major protective and neutralization antigen of SARS-CoV-2. B/HPIV3/S and B/HPIV3/S-2P replicated as efficiently as B/HPIV3 in vitro and stably expressed SARS-CoV-2 S. Prefusion stabilization increased S expression by B/HPIV3 in vitro. In hamsters, a single intranasal dose of B/HPIV3/S-2P induced significantly higher titers compared to B/HPIV3/S of serum SARS-CoV-2–neutralizing antibodies (12- fold higher), serum IgA and IgG to SARS-CoV-2 S protein (5-fold and 13-fold), and IgG to the receptor binding domain (10-fold). Antibodies exhibited broad neutralizing activity against SARSCoV-2 of lineages A, B.1.1.7, and B.1.351. Four weeks after immunization, hamsters were challenged intranasally with 104.5 50% tissue-culture infectious-dose (TCID50) of SARS-CoV-2. In B/HPIV3 empty vector-immunized hamsters, SARS-CoV-2 replicated to mean titers of 106.6 TCID50/g in lungs and 107 TCID50/g in nasal tissues and induced moderate weight loss. In B/HPIV3/S-immunized hamsters, SARS-CoV-2 challenge virus was reduced 20-fold in nasal tissues and undetectable in lungs. In B/HPIV3/S-2P–immunized hamsters, infectious challenge virus was undetectable in nasal tissues and lungs; B/HPIV3/S and B/HPIV3/S-2P completely protected against weight loss after SARS-CoV-2 challenge. B/HPIV3/S-2P is a promising vaccine candidate to protect infants and young children against HPIV3 and SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Limited Pulmonary Mucosal-Associated Invariant T Cell Accumulation and Activation during Mycobacterium tuberculosis Infection in Rhesus Macaques

Author

Kauffman, Keith D., primary, Sallin, Michelle A., additional, Hoft, Stella G., additional, Sakai, Shunsuke, additional, Moore, Rashida, additional, Wilder-Kofie, Temeri, additional, Moore, Ian N., additional, Sette, Alessandro, additional, Arlehamn, Cecilia S. Lindestam, additional, and Barber, Daniel L., additional

Published
2018
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41. Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma

Author

Diaz, Giacomo, primary, Engle, Ronald E., additional, Tice, Ashley, additional, Melis, Marta, additional, Montenegro, Stephanie, additional, Rodriguez-Canales, Jaime, additional, Hanson, Jeffrey, additional, Emmert-Buck, Michael R., additional, Bock, Kevin W., additional, Moore, Ian N., additional, Zamboni, Fausto, additional, Govindarajan, Sugantha, additional, Kleiner, David E., additional, and Farci, Patrizia, additional

Published
2018
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42. First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis

Author

Myles, Ian A., primary, Earland, Noah J., additional, Anderson, Erik D., additional, Moore, Ian N., additional, Kieh, Mark D., additional, Williams, Kelli W., additional, Saleem, Arhum, additional, Fontecilla, Natalia M., additional, Welch, Pamela A., additional, Darnell, Dirk A., additional, Barnhart, Lisa A., additional, Sun, Ashleigh A., additional, Uzel, Gulbu, additional, and Datta, Sandip K., additional

Published
2018
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43. Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection

Author

Martin-Martin, Ines, primary, Chagas, Andrezza Campos, additional, Guimaraes-Costa, Anderson B., additional, Amo, Laura, additional, Oliveira, Fabiano, additional, Moore, Ian N., additional, DeSouza-Vieira, Thiago S., additional, Sanchez, Elda E., additional, Suntravat, Montamas, additional, Valenzuela, Jesus G., additional, Ribeiro, Jose M. C., additional, and Calvo, Eric, additional

Published
2018
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45. In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice

Author

Sutton, Troy C., primary, Lamirande, Elaine W., additional, Bock, Kevin W., additional, Moore, Ian N., additional, Koudstaal, Wouter, additional, Rehman, Muniza, additional, Weverling, Gerrit Jan, additional, Goudsmit, Jaap, additional, and Subbarao, Kanta, additional

Published
2017
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47. Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody

Author

Houser, Katherine V., primary, Broadbent, Andrew J., additional, Gretebeck, Lisa, additional, Vogel, Leatrice, additional, Lamirande, Elaine W., additional, Sutton, Troy, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Orandle, Marlene, additional, Moore, Ian N., additional, and Subbarao, Kanta, additional

Published
2017
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49. Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure.

Author

Zhaochun Chen, Engle, Ronald E., De Battista, Davide, Purcell, Robert H., Farci, Patrizia, Pollicino, Teresa, Wollenberg, Kurt, Govindarajan, Sugantha, Kleiner, David E., Diaz, Giacomo, Huaying Zhao, Schuck, Peter, Chen-Hsiang Shen, Soto, Cinque, Kwong, Peter D., Zamboni, Fausto, Zhifeng Long, Kabat, Juraj, Bock, Kevin W., and Moore, Ian N.

Subjects
HEPATITIS B virus, LIVER failure, HEPATITIS associated antigen, HUMORAL immunity, ANIMAL models in research
Abstract

Hepatitis B virus (HBV)-associated acute liver failure (ALF) is a dramatic clinical syndrome leading to death or liver transplantation in 80% of cases. Due to the extremely rapid clinical course, the difficulties in obtaining liver specimens, and the lack of an animal model, the pathogenesis of ALF remains largely unknown. Here, we performed a comprehensive genetic and functional characterization of the virus and the host in liver tissue from HBV-associated ALF and compared the results with those of classic acute hepatitis B in chimpanzees. In contrast with acute hepatitis B, HBV strains detected in ALF livers displayed highly mutated HBV core antigen (HBcAg), associated with increased HBcAg expression ex vivo, which was independent of viral replication levels. Combined gene and miRNA expression profiling revealed a dominant B cell disease signature, with extensive intrahepatic production of IgM and IgG in germline configuration exclusively targeting HBcAg with subnanomolar affinities, and complement deposition. Thus, HBV ALF appears to be an anomalous T cell-independent, HBV core-driven B cell disease, which results from the rare and unfortunate encounter between a host with an unusual B cell response and an infecting virus with a highly mutated core antigen. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease

Author

Johnson, Reed F., primary, Hammoud, Dima A., additional, Perry, Donna L., additional, Solomon, Jeffrey, additional, Moore, Ian N., additional, Lackemeyer, Matthew G., additional, Bohannon, Jordan K., additional, Sayre, Philip J., additional, Minai, Mahnaz, additional, Papaneri, Amy B., additional, Hagen, Katie R., additional, Janosko, Krisztina B., additional, Jett, Catherine, additional, Cooper, Kurt, additional, Blaney, Joseph E., additional, and Jahrling, Peter B., additional

Published
2016
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