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2. Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Author

Loo, Sun, Potter, Nicola, Ivey, Adam, O’Nions, Jenny, Moon, Roderick, Jovanovic, Jelena, Fong, Chun Y., Anstee, Natasha S., Tiong, Ing Soo, Othman, Jad, Chua, Chong Chyn, Renshaw, Hanna, Baker, Robert, Fleming, Shaun, Russell, Nigel H., Ritchie, David, Bajel, Ashish, Hou, Hsin-An, Dillon, Richard, and Wei, Andrew H.

Abstract

Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).

Published
2024
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