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3. Myocardial Perfusion with Multislice Computed Tomography in Stable Angina Pectoris

Author

Rossi, Alexia, Merkus, D, Klotz, E, Mollet, N, de Feyter PJ, Krestin, Gp, Rossi, Alexia, Merkus, D, Klotz, E, Mollet, N, de Feyter, Pj, and Krestin, Gp

Subjects
CT myocardial perfusion imaging
Abstract

Computed tomographic (CT) coronary angiography is a well-established, noninvasive imaging modality for detection of coronary stenosis, but it has limited accuracy in demonstrating whether a coronary stenosis is hemodynamically significant. An additional functional test is often required because both anatomic and functional information is needed for guiding patient care. Recent developments in CT technology allow CT evaluation of myocardial perfusion during vasodilator stress, thereby providing information about myocardial ischemia. Investigators in several single-center studies have established the feasibility of performing stress myocardial perfusion CT imaging in small groups of patients and have shown that stress myocardial perfusion CT in combination with CT coronary angiography improved the diagnostic accuracy in comparison with CT coronary angiography alone. However, CT perfusion acquisition protocols must be optimized in terms of acquisition and reconstruction parameters, contrast material protocol injections, and radiation dose. Further research is needed to establish the clinical usefulness of this novel technique. The purpose of this review is to (a) provide an overview of the physiology of coronary circulation and myocardial perfusion; (b) describe the technical prerequisites, challenges, and mathematic modeling related to CT perfusion imaging; (c) note recent advances in CT scanners and CT perfusion protocols; and (d) discuss the interpretation of CT perfusion images. Finally, a review and summary of the current literature are provided, and future directions for research are discussed.

Published
2014

4. Image assessment with multislice CT coronary angiography

Author

Cademartiri, F., Marano, R., Luccichenti, G., Mollet, N., Giuseppe Runza, Galia, M., Belgrano, M., Gualerzi, M., Brambilla, L., Coruzzi, P., Midiri, M., CADEMARTIRI F, MARANO R, LUCCICHENTI G, MOLLET N, RUNZA G, GALIA M, BELGRANO M, GUALERZI M, BRAMBILLA M, CORUZZI P, MIDIRI M, Cademartiri, F., Marano, R., Luccichenti, G., Mollet, N., Runza, G., Galia, M., Belgrano, MANUEL GIANVALERIO, Gualerzi, M., Brambilla, L., Coruzzi, P., Midiri, M., Radiology & Nuclear Medicine, and Cardiology

Published
2005

7. Images in cardiovascular medicine. Motion-free ECG-gated 16-row multislice computed tomography in the follow-up of aortic coarctation with three-dimensional volume rendering

Author

Filippo Cademartiri, Mollet, N., Nieman, K., Alfieri, O., Krestin, G. P., Cademartiri, F, Mollet, N, Nieman, K, Alfieri, Ottavio, Krestin, Gp, Radiology & Nuclear Medicine, and Cardiology

Subjects
Adult, Male, Electrocardiography, Imaging, Three-Dimensional, Image Processing, Computer-Assisted, Humans, Aorta, Thoracic, Cardiac Surgical Procedures, Tomography, X-Ray Computed, Aortic Coarctation
Published
2004

8. Non-invasive 16-row spiral multislice computed tomography coronary angiography after one year of experience

Author

Filippo Cademartiri, Nieman K, Mollet N, Tg, Flohr, Alfieri O, Pj, Feyter, Gp, Krestin, Cademartiri, F, Nieman, K, Mollet, N, Flohr, Tg, Alfieri, Ottavio, de Feyter, Pj, and Krestin, Gp

Subjects
Male, Coronary Stenosis, Coronary Disease, Coronary Artery Disease, Middle Aged, Coronary Angiography, Sensitivity and Specificity, Ventricular Function, Left, Angina Pectoris, Electrocardiography, Heart Rate, Humans, Stents, Angioplasty, Balloon, Coronary, Tomography, Spiral Computed, Algorithms
Abstract

The gold standard for direct diagnostic imaging of coronary arteries is still conventional X-ray coronary angiography, even though for several other applications, noninvasive techniques substituted invasive ones. In the last 10 years several techniques (magnetic resonance, electron beam tomography, spiral computed tomography) attempted to emerge as noninvasive modality for the study of coronary arteries. The introduction of multislice computed tomography (MSCT) with retrospectively gated ECG reconstructions has substantially modified the coronary imaging scenario. In fact, the results have been promising since the beginning with 4-row MSCT. Currently the results reported with 16-row MSCT allow to question which role can the noninvasive coronary angiography play in clinical settings. With a scan of < 20 s after intravenous administration of iodinated contrast material it is possible to obtain information similar to conventional coronary angiography. Moreover, together with vascular patency, also atherosclerotic plaques are well visualized and characterized (type: calcified, soft, mixed). Ongoing studies are validating MSCT in the assessment of plaque vulnerability. The same technique allows to evaluate left ventricular function and myocardial wall motion impairment. Still with a few major limitations related to the heart rate, MSCT will broaden the noninvasive capability of evaluating coronary arteries in patients where conventional coronary angiography is exceeding the actual clinical question or considered as premature.

Published
2003

9. Left ventricular ejection fraction: real-world comparison between cardiac computed tomography and echocardiography in a large population

Author

Maffei E, Messalli G, Palumbo A, Martini C, Seitun S, Aldrovandi A, Cuttone A, Emiliano E, Malagò R, Weustink A, Mollet N, Filippo Cademartiri, Radiology & Nuclear Medicine, and Cardiology

Subjects
Adult, Aged, 80 and over, Male, Left ventricular ejection fraction, Cardiac computed tomography, genetic structures, Adolescent, Real world, Stroke Volume, Coronary Artery Disease, Middle Aged, Ventricular Function, Left, stomatognathic diseases, Young Adult, Echocardiography, Cardiac computed tomography, Echocardiography, Left ventricular ejection fraction, Real world, Humans, Female, Child, Tomography, X-Ray Computed, Aged
Abstract

Purpose. This study compared cardiac computed tomography (CT) and two-dimensional transthoracic echocardiography (ECC) for assessing left ventricular ejection fraction (LVEF) using real-world data from a large patient population. Materials and methods. We studied 450 patients (284 males; mean age 64 +/- 12 years; range 12-88) who underwent CT and ECC due to suspected coronary artery disease. For CT, we used multiphase short-axis reconstructions and evaluated them with a dedicated software tool that uses Simpson's rule to compute LV volumes. For ECC, computation was based on the biplane Simpson's method. Results in terms of EF were compared with the paired Student's t test, Pearson's correlation coefficient (r), and Bland-Altman analysis. Results. EF was 52%+/- 15% for CT and 55%+/- 13% for ECC. Statistically significant differences, albeit with correlation, were observed between the measurements (r=0.71; p50% and overestimated in those with EF 35%-50% and

Published
2009

10. Abstracts

Author

Dunet, V., primary, Dabiri, A., additional, Allenbach, G., additional, Goyeneche Achigar, A., additional, Waeber, B., additional, Feihl, F., additional, Heinzer, R., additional, Prior, J. O., additional, Van Velzen, J. E., additional, Schuijf, J. D., additional, De Graaf, F. R., additional, De Graaf, M. A., additional, Schalij, M. J., additional, Kroft, L. J., additional, De Roos, A., additional, Jukema, J. W., additional, Van Der Wall, E. E., additional, Bax, J. J., additional, Lankinen, E., additional, Saraste, A., additional, Noponen, T., additional, Klen, R., additional, Teras, M., additional, Kokki, T., additional, Kajander, S., additional, Pietila, M., additional, Ukkonen, H., additional, Knuuti, J., additional, Pazhenkottil, A. P., additional, Nkoulou, R. N., additional, Ghadri, J. R., additional, Herzog, B. A., additional, Buechel, R. R., additional, Kuest, S. M., additional, Wolfrum, M., additional, Gaemperli, O., additional, Husmann, L., additional, Kaufmann, P. A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Antonioli, L., additional, Bertella, E., additional, Formenti, A., additional, Cortinovis, S., additional, Ballerini, G., additional, Fiorentini, C., additional, Pepi, M., additional, Koh, A. S., additional, Flores, J. S., additional, Keng, F. Y. J., additional, Tan, R. S., additional, Chua, T. S. J., additional, Annoni, A. D., additional, Tamborini, G., additional, Fusari, M., additional, Bartorelli, A. L., additional, Ewe, S. H., additional, Ng, A. C. T., additional, Delgado, V., additional, Schuijf, J., additional, Van Der Kley, F., additional, Colli, A., additional, De Weger, A., additional, Marsan, N. A., additional, Yiu, K. H., additional, Ng, A. C., additional, Timmer, S. A. J., additional, Knaapen, P., additional, Germans, T., additional, Dijkmans, P. A., additional, Lubberink, M., additional, Ten Berg, J. M., additional, Ten Cate, F. J., additional, Russel, I. K., additional, Lammertsma, A. A., additional, Van Rossum, A. C., additional, Wong, Y. Y., additional, Ruiter, G., additional, Raijmakers, P., additional, Van Der Laarse, W. J., additional, Westerhof, N., additional, Vonk-Noordegraaf, A., additional, Youssef, G., additional, Leung, E., additional, Wisenberg, G., additional, Marriot, C., additional, Williams, K., additional, Etele, J., additional, Dekemp, R. A., additional, Dasilva, J., additional, Birnie, D., additional, Beanlands, R. S. B., additional, Thompson, R. C., additional, Allam, A. H., additional, Wann, L. S., additional, Nureldin, A. H., additional, Adelmaksoub, G., additional, Badr, I., additional, Sutherland, M. L., additional, Sutherland, J. D., additional, Miyamoto, M. I., additional, Thomas, G. S., additional, Harms, H. J., additional, De Haan, S., additional, Huisman, M. C., additional, Schuit, R. C., additional, Windhorst, A. D., additional, Allaart, C., additional, Einstein, A. J., additional, Khawaja, T., additional, Greer, C., additional, Chokshi, A., additional, Jones, M., additional, Schaefle, K., additional, Bhatia, K., additional, Shimbo, D., additional, Schulze, P. C., additional, Srivastava, A., additional, Chettiar, R., additional, Moody, J., additional, Weyman, C., additional, Natale, D., additional, Bruni, W., additional, Liu, Y., additional, Ficaro, E., additional, Sinusas, A. J., additional, Peix, A., additional, Batista, E., additional, Cabrera, L. O., additional, Padron, K., additional, Rodriguez, L., additional, Sainz, B., additional, Mendoza, V., additional, Carrillo, R., additional, Fernandez, Y., additional, Mena, E., additional, Naum, A., additional, Bach-Gansmo, T., additional, Kleven-Madsen, N., additional, Biermann, M., additional, Johnsen, B., additional, Aase Husby, J., additional, Rotevatn, S., additional, Nordrehaug, J. E., additional, Schaap, J., additional, Kauling, R. M., additional, Post, M. C., additional, Rensing, B. J. W. M., additional, Verzijlbergen, J. F., additional, Sanchez, J., additional, Giamouzis, G., additional, Tziolas, N., additional, Georgoulias, P., additional, Karayannis, G., additional, Chamaidi, A., additional, Zavos, N., additional, Koutrakis, K., additional, Sitafidis, G., additional, Skoularigis, J., additional, Triposkiadis, F., additional, Radovanovic, S., additional, Djokovic, A., additional, Simic, D. V., additional, Krotin, M., additional, Savic-Radojevic, A., additional, Pljesa-Ercegovac, M., additional, Zdravkovic, M., additional, Saponjski, J., additional, Jelic, S., additional, Simic, T., additional, Eckardt, R., additional, Kjeldsen, B. J., additional, Andersen, L. I., additional, Haghfelt, T., additional, Grupe, P., additional, Johansen, A., additional, Hesse, B., additional, Pena, H., additional, Cantinho, G., additional, Wilk, M., additional, Srour, Y., additional, Godinho, F., additional, Zafrir, N., additional, Gutstein, A., additional, Mats, I., additional, Battler, A., additional, Solodky, A., additional, Sari, E., additional, Singh, N., additional, Vara, A., additional, Peters, A. M., additional, De Belder, A., additional, Nair, S., additional, Ryan, N., additional, James, R., additional, Dizdarevic, S., additional, Depuey, G., additional, Friedman, M., additional, Wray, R., additional, Old, R., additional, Babla, H., additional, Chuanyong, B., additional, Maddahi, J., additional, Tragardh Johansson, E., additional, Sjostrand, K., additional, Edenbrandt, L., additional, Aguade-Bruix, S., additional, Cuberas-Borros, G., additional, Pizzi, M. N., additional, Sabate-Fernandez, M., additional, De Leon, G., additional, Garcia-Dorado, D., additional, Castell-Conesa, J., additional, Candell-Riera, J., additional, Casset-Senon, D., additional, Edjlali-Goujon, M., additional, Alison, D., additional, Delhommais, A., additional, Cosnay, P., additional, Low, C. S., additional, Notghi, A., additional, O'brien, J., additional, Tweddel, A. C., additional, Bingham, N., additional, O Neil, P., additional, Harbinson, M., additional, Lindner, O., additional, Burchert, W., additional, Schaefers, M., additional, Marcassa, C., additional, Campini, R., additional, Calza, P., additional, Zoccarato, O., additional, Kisko, A., additional, Kmec, J., additional, Babcak, M., additional, Vereb, M., additional, Vytykacova, M., additional, Cencarik, J., additional, Gazdic, P., additional, Stasko, J., additional, Abreu, A., additional, Pereira, E., additional, Oliveira, L., additional, Colarinha, P., additional, Veloso, V., additional, Enriksson, I., additional, Proenca, G., additional, Delgado, P., additional, Rosario, L., additional, Sequeira, J., additional, Kosa, I., additional, Vassanyi, I., additional, Egyed, C. S., additional, Kozmann, G. Y., additional, Morita, S., additional, Nanasato, M., additional, Nanbu, I., additional, Yoshida, Y., additional, Hirayama, H., additional, Allam, A., additional, Sharef, A., additional, Shawky, I., additional, Farid, M., additional, Mouden, M., additional, Ottervanger, J. P., additional, Timmer, J. R., additional, De Boer, M. J., additional, Reiffers, S., additional, Jager, P. L., additional, Knollema, S., additional, Nasr, G. M., additional, Mohy Eldin, M., additional, Ragheb, M., additional, Casans-Tormo, I., additional, Diaz-Exposito, R., additional, Hurtado-Mauricio, F. J., additional, Ruano, R., additional, Diego, M., additional, Gomez-Caminero, F., additional, Albarran, C., additional, Martin De Arriba, A., additional, Rosero, A., additional, Lopez, R., additional, Martin Luengo, C., additional, Garcia-Talavera, J. R., additional, Laitinen, I. E. K., additional, Rudelius, M., additional, Weidl, E., additional, Henriksen, G., additional, Wester, H. J., additional, Schwaiger, M., additional, Pan, X. B., additional, Schindler, T., additional, Quercioli, A., additional, Zaidi, H., additional, Ratib, O., additional, Declerck, J. M., additional, Alexanderson Rosas, E., additional, Jacome, R., additional, Jimenez-Santos, M., additional, Romero, E., additional, Pena-Cabral, M. A., additional, Meave, A., additional, Gonzalez, J., additional, Rouzet, F., additional, Bachelet, L., additional, Alsac, J. M., additional, Suzuki, M., additional, Louedec, L., additional, Petiet, A., additional, Chaubet, F., additional, Letourneur, D., additional, Michel, J. B., additional, Le Guludec, D., additional, Aktas, A., additional, Cinar, A., additional, Yaman, G., additional, Bahceci, T., additional, Kavak, K., additional, Gencoglu, A., additional, Jimenez-Heffernan, A., additional, Sanchez De Mora, E., additional, Lopez-Martin, J., additional, Lopez-Aguilar, R., additional, Ramos, C., additional, Salgado, C., additional, Ortega, A., additional, Sanchez-Gonzalez, C., additional, Roa, J., additional, Tobaruela, A., additional, Nesterov, S. V., additional, Turta, O., additional, Maki, M., additional, Han, C., additional, Daou, D., additional, Tawileh, M., additional, Chamouine, S. O., additional, Coaguila, C., additional, Mariscal-Labrador, E., additional, Kisiel-Gonzalez, N., additional, De Araujo Goncalves, P., additional, Sousa, P. J., additional, Marques, H., additional, O'neill, J., additional, Pisco, J., additional, Cale, R., additional, Brito, J., additional, Gaspar, A., additional, Machado, F. P., additional, Roquette, J., additional, Martinez, M., additional, Melendez, G., additional, Kimura, E., additional, Ochoa, J. M., additional, Alessio, A. M., additional, Patel, A., additional, Lautamaki, R., additional, Bengel, F. M., additional, Bassingthwaighte, J. B., additional, Caldwell, J. H., additional, Rahbar, K., additional, Seifarth, H., additional, Schafers, M., additional, Stegger, L., additional, Spieker, T., additional, Hoffmeier, A., additional, Maintz, D., additional, Scheld, H., additional, Schober, O., additional, Weckesser, M., additional, Aoki, H., additional, Matsunari, I., additional, Kajinami, K., additional, Martin Fernandez, M., additional, Barreiro Perez, M., additional, Fernandez Cimadevilla, O. V., additional, Leon Duran, D., additional, Velasco Alonso, E., additional, Florez Munoz, J. P., additional, Luyando, L. H., additional, Templin, C., additional, Veltman, C. E., additional, Reiber, J. H. C., additional, Venuraju, S., additional, Yerramasu, A., additional, Atwal, S., additional, Lahiri, A., additional, Kunimasa, T., additional, Shiba, M., additional, Ishii, K., additional, Aikawa, J., additional, Kroner, E. S. J., additional, Ho, K. T., additional, Yong, Q. W., additional, Chua, K. C., additional, Panknin, C., additional, Roos, C. J., additional, Van Werkhoven, J. M., additional, Witkowska-Grzeslo, A. J., additional, Boogers, M. J., additional, Anand, D. V., additional, Dey, D., additional, Berman, D., additional, Mut, F., additional, Giubbini, R., additional, Lusa, L., additional, Massardo, T., additional, Iskandrian, A., additional, Dondi, M., additional, Sato, A., additional, Kakefuda, Y., additional, Ojima, E., additional, Adachi, T., additional, Atsumi, A., additional, Ishizu, T., additional, Seo, Y., additional, Hiroe, M., additional, Aonuma, K., additional, Kruk, M., additional, Pracon, R., additional, Kepka, C., additional, Pregowski, J., additional, Kowalewska, A., additional, Pilka, M., additional, Opolski, M., additional, Michalowska, I., additional, Dzielinska, Z., additional, Demkow, M., additional, Stoll, V., additional, Sabharwal, N., additional, Chakera, A., additional, Ormerod, O., additional, Fernandes, H., additional, Bernardes, M., additional, Martins, E., additional, Oliveira, P., additional, Vieira, T., additional, Terroso, G., additional, Oliveira, A., additional, Faria, T., additional, Ventura, F., additional, Pereira, J., additional, Fukuzawa, S., additional, Inagaki, M., additional, Sugioka, J., additional, Ikeda, A., additional, Okino, S., additional, Maekawa, J., additional, Uchiyama, T., additional, Kamioka, N., additional, Ichikawa, S., additional, Afshar, M., additional, Alvi, R., additional, Aguilar, N., additional, Ippili, R., additional, Shaqra, H., additional, Bella, J., additional, Bhalodkar, N., additional, Dos Santos, A., additional, Daicz, M., additional, Cendoya, L. O., additional, Marrero, H. G., additional, Casuscelli, J., additional, Embon, M., additional, Vera Janavel, G., additional, Duronto, E., additional, Gurfinkel, E. P., additional, Cortes, C. M., additional, Takeishi, Y., additional, Nakajima, K., additional, Yamasaki, Y., additional, Nishimura, T., additional, Hayes Brown, K., additional, Collado, F., additional, Alhaji, M., additional, Green, J., additional, Alexander, S., additional, Vashistha, R., additional, Jain, S., additional, Aldaas, F., additional, Shanes, J., additional, Doukky, R., additional, Ashikaga, K., additional, Akashi, Y. J., additional, Uemarsu, M., additional, Kamijima, R., additional, Yoneyama, K., additional, Omiya, K., additional, Miyake, Y., additional, Brodov, Y., additional, Raval, U., additional, Berezin, A., additional, Seden, V., additional, Koretskaya, E., additional, Panasenko, T. A., additional, Matsuo, S., additional, Kinuya, S., additional, Chen, J., additional, Van Bommel, R. J., additional, Van Der Hiel, B., additional, Dibbets-Schneider, P., additional, Garcia, E. V., additional, Rutten-Vermeltfoort, I., additional, Gevers, M. M. J., additional, Verhoeven, B., additional, Dijk Van, A. B., additional, Raaijmakers, E., additional, Raijmakers, P. G. H. M., additional, Engvall, J. E., additional, Gjerde, M., additional, De Geer, J., additional, Olsson, E., additional, Quick, P., additional, Persson, A., additional, Mazzanti, M., additional, Marini, M., additional, Pimpini, L., additional, Perna, G. P., additional, Marciano, C., additional, Gargiulo, P., additional, Galderisi, M., additional, D'amore, C., additional, Savarese, G., additional, Casaretti, L., additional, Paolillo, S., additional, Cuocolo, A., additional, Perrone Filardi, P., additional, Al-Amoodi, M., additional, Thompson, E. C., additional, Kennedy, K., additional, Bybee, K. A., additional, Mcghie, A. I., additional, O'keefe, J. H., additional, Bateman, T. M., additional, Van Der Palen, R. L. F., additional, Mavinkurve-Groothuis, A. M., additional, Bulten, B., additional, Bellersen, L., additional, Van Laarhoven, H. W. M., additional, Kapusta, L., additional, De Geus-Oei, L. F., additional, Pollice, P. P., additional, Bonifazi, M. B., additional, Pollice, F. P., additional, Clements, I. P., additional, Hodge, D. O., additional, Scott, C. G., additional, De Ville De Goyet, M., additional, Brichard, B., additional, Pirotte, T., additional, Moniotte, S., additional, Tio, R. A., additional, Elvan, A., additional, Dierckx, R. A. I. O., additional, Slart, R. H. J. A., additional, Furuhashi, T., additional, Moroi, M., additional, Hase, H., additional, Joki, N., additional, Masai, H., additional, Nakazato, R., additional, Fukuda, H., additional, Sugi, K., additional, Kryczka, K., additional, Kaczmarska, E., additional, Petryka, J., additional, Mazurkiewicz, L., additional, Ruzyllo, W., additional, Smanio, P., additional, Vieira Segundo, E., additional, Siqueira, M., additional, Kelendjian, J., additional, Ribeiro, J., additional, Alaca, J., additional, Oliveira, M., additional, Alves, F., additional, Peovska, I., additional, Maksimovic, J., additional, Vavlukis, M., additional, Kostova, N., additional, Pop Gorceva, D., additional, Majstorov, V., additional, Zdraveska, M., additional, Hussain, S., additional, Djearaman, M., additional, Hoey, E., additional, Morus, L., additional, Erinfolami, O., additional, Macnamara, A., additional, Opolski, M. P., additional, Witkowski, A., additional, Berti, V., additional, Ricci, F., additional, Gallicchio, R., additional, Acampa, W., additional, Cerisano, G., additional, Vigorito, C., additional, Sciagra', R., additional, Pupi, A., additional, Sliem, H., additional, Collado, F. M., additional, Schmidt, S., additional, Maheshwari, A., additional, Kiriakos, R., additional, Mwansa, V., additional, Ljubojevic, S., additional, Sedej, S., additional, Holzer, M., additional, Marsche, G., additional, Marijanski, V., additional, Kockskaemper, J., additional, Pieske, B., additional, Ricalde, A., additional, Alexanderson, G., additional, Mohani, A., additional, Khanna, P., additional, Sinusas, A., additional, Lee, F., additional, Pinas, V. A., additional, Van Eck-Smit, B. L. F., additional, Verberne, H. J., additional, De Bruin, C. M., additional, Guilhermina, G., additional, Jimenez-Angeles, L., additional, Ruiz De Jesus, O., additional, Yanez-Suarez, O., additional, Vallejo, E., additional, Reyes, E., additional, Chan, M., additional, Hossen, M. L., additional, Underwood, S. R., additional, Karu, A., additional, Bokhari, S., additional, Pineda, V., additional, Gracia-Sanchez, L. M., additional, Garcia-Burillo, A., additional, Zavadovskiy, K., additional, Lishmanov, Y. U., additional, Saushkin, W., additional, Kovalev, I., additional, Chernishov, A., additional, Annoni, A., additional, Tarkia, M., additional, Saanijoki, T., additional, Oikonen, V., additional, Savunen, T., additional, Green, M. A., additional, Strandberg, M., additional, Roivainen, A., additional, Gaeta, M. C., additional, Artigas, C., additional, Deportos, J., additional, Geraldo, L., additional, Flotats, A., additional, La Delfa, V., additional, Carrio, I., additional, Laarse, W. J., additional, Izquierdo Gomez, M. M., additional, Lacalzada Almeida, J., additional, Barragan Acea, A., additional, De La Rosa Hernandez, A., additional, Juarez Prera, R., additional, Blanco Palacios, G., additional, Bonilla Arjona, J. A., additional, Jimenez Rivera, J. J., additional, Iribarren Sarrias, J. L., additional, Laynez Cerdena, I., additional, Dedic, A., additional, Rossi, A., additional, Ten Kate, G. J. R., additional, Dharampal, A., additional, Moelker, A., additional, Galema, T. W., additional, Mollet, N., additional, De Feyter, P. J., additional, Nieman, K., additional, Trabattoni, D., additional, Broersen, A., additional, Frenay, M., additional, Boogers, M. M., additional, Kitslaar, P. H., additional, Dijkstra, J., additional, Annoni, D. A., additional, Muratori, M., additional, Johki, N., additional, Tokue, M., additional, Dharampal, A. S., additional, Weustink, A. C., additional, Neefjes, L. A. E., additional, Papadopoulou, S. L., additional, Chen, C., additional, Mollet, N. R. A., additional, Boersma, E. H., additional, Krestin, G. P., additional, Purvis, J. A., additional, Sharma, D., additional, Hughes, S. M., additional, Berman, D. S., additional, Taillefer, R., additional, Udelson, J., additional, Devine, M., additional, Lazewatsky, J., additional, Bhat, G., additional, Washburn, D., additional, Patel, D., additional, Mazurek, T., additional, Tandon, S., additional, Bansal, S., additional, Inzucchi, S., additional, Staib, L., additional, Davey, J., additional, Chyun, D., additional, Young, L., additional, Wackers, F., additional, Harbinson, M. T., additional, Wells, G., additional, Dougan, J., additional, Borges-Neto, S., additional, Phillips, H., additional, Farzaneh-Far, A., additional, Starr, Z., additional, Shaw, L. K., additional, Fiuzat, M., additional, O'connor, C., additional, Henzlova, M., additional, Duvall, W. L., additional, Levine, A., additional, Baber, U., additional, Croft, L., additional, Sahni, S., additional, Sethi, S., additional, Hermann, L., additional, Nureldin, A., additional, Gomaa, A., additional, Soliman, M. A. T., additional, Hany, H. A. R., additional, De Graaf, F., additional, Pazhenkottil, A., additional, Siebelink, H. M. J., additional, Reiber, J. H., additional, Ayub, M., additional, Naveed, T., additional, Azhar, M., additional, Van Tosh, A., additional, Faber, T. L., additional, Votaw, J. R., additional, Reichek, N., additional, Pulipati, B., additional, Palestro, C., additional, Nichols, K. J., additional, Okuda, K., additional, Kirihara, Y., additional, Ishikawa, T., additional, Taki, J., additional, Yoshita, M., additional, Yamada, M., additional, Salacata, A., additional, Keavey, S., additional, Chavarri, V., additional, Mills, J., additional, Nagaraj, H., additional, Bhambhani, P., additional, Kliner, D. E., additional, Soman, P., additional, Heo, J., additional, Iskandrian, A. E., additional, Jain, M., additional, Lin, B., additional, Walker, A., additional, Nkonde, C., additional, Bond, S., additional, Baskin, A., additional, Declerck, J., additional, Soto, M. E., additional, Mendoza, G., additional, Aguilar, M., additional, Williams, S. P., additional, Colice, G., additional, Mcardle, J. R., additional, Lankford, A., additional, Kajdasz, D. K., additional, Reed, C. R., additional, Angelini, L., additional, Angelozzi, F., additional, Ascoli, G., additional, Jacobson, A., additional, Lessig, H. J., additional, Gerson, M. C., additional, Cerqueira, M. D., additional, Narula, J., additional, Uematsu, M., additional, Kida, K., additional, Suzuki, K., additional, Bravo, P. E., additional, Fukushima, K., additional, Chaudhry, M., additional, Merrill, J., additional, Alonso Tello, A., additional, Rodriguez Palomares, J. F., additional, Marti Aguasca, G., additional, Aguade Bruix, S., additional, Aliaga, V., additional, Mahia, P., additional, Gonzalez-Alujas, T., additional, Candell, J., additional, Evangelista, A., additional, Mlynarski, R., additional, Mlynarska, A., additional, Sosnowski, M., additional, Zerahn, B., additional, Hasbak, P., additional, Mortensen, C. E., additional, Mathiesen, H. F., additional, Andersson, M., additional, Nielsen, D., additional, Ferreira Santos, L., additional, Ferreira, M. J., additional, Ramos, D., additional, Moreira, D., additional, Cunha, M. J., additional, Albuquerque, A., additional, Moreira, A., additional, Oliveira Santos, J., additional, Costa, G., additional, Providencia, L. A., additional, Arita, Y., additional, Kihara, S., additional, Mitsusada, N., additional, Miyawaki, M., additional, Ueda, H., additional, Hiraoka, H., additional, Matsuzawa, Y., additional, Askew, J., additional, O'connor, M., additional, Jordan, L., additional, Ruter, R., additional, Gibbons, R., additional, Miller, T., additional, Emmett, L., additional, Ng, A., additional, Sorensen, N., additional, Mansberg, R., additional, Kritharides, L., additional, Gonzalez, T., additional, Majmundar, H., additional, Coats, N. P., additional, Vernotico, S., additional, Doan, J. H., additional, Hernandez, T. M., additional, Evini, M., additional, Hepner, A. D., additional, Ip, T. K., additional, Chalela, W. A., additional, Falcao, A. M., additional, Azouri, L. O., additional, Ramires, J. A. F., additional, Meneghetti, J. C., additional, Manganelli, F., additional, Spadafora, M., additional, Varrella, P., additional, Peluso, G., additional, Sauro, R., additional, Di Lorenzo, E., additional, Rotondi, F., additional, Daniele, S., additional, Miletto, P., additional, Rijnders, A. J. M., additional, Hendrickx, B. W., additional, Van Der Bruggen, W., additional, America, Y. G. C. J., additional, Thorley, P. J., additional, Chowdhury, F. U., additional, Dickinson, C. J., additional, Sazonova, S. I., additional, Proskokova, I. Y. U., additional, Gusakova, A. M., additional, Minin, S. M., additional, Lishmanov, Y. U. B., additional, Saushkin, V. V., additional, Rodriguez, G., additional, Roffe, F., additional, Ilarraza, H., additional, Bialostozky, D., additional, Kitsiou, A. N., additional, Arsenos, P., additional, Tsiantis, I., additional, Charizopoulos, S., additional, Karas, S., additional, Vidal Perez, R. C., additional, Garrido, M., additional, Pubul, V., additional, Argibay, S., additional, Pena, C., additional, Pombo, M., additional, Ciobotaru, A. B., additional, Sanchez-Salmon, A., additional, Ruibal Morell, A., additional, Gonzalez-Juanatey, J. R., additional, Rodriguez-Gomez, E., additional, Martinez, B., additional, Pontillo, D., additional, Benvissuto, F., additional, Fiore Melacrinis, F., additional, Maccafeo, S., additional, Scabbia, E. V., additional, Schiavo, R., additional, Golzar, Y., additional, Gidea, C., additional, Golzar, J., additional, Pop-Gorceva, D., additional, Zdravkovska, M., additional, Stojanovski, S., additional, Georgievska-Ismail, L. J., additional, Katsikis, T., additional, Theodorakos, A., additional, Kouzoumi, A., additional, Koutelou, M., additional, Yoshimura, Y., additional, Toyama, T., additional, Hoshizaki, H., additional, Ohshima, S., additional, Inoue, M., additional, Suzuki, T., additional, Uitterdijk, A., additional, Dijkshoorn, M., additional, Van Straten, M., additional, Van Der Giessen, W. J., additional, Duncker, D. J., additional, Merkus, D., additional, Platsch, G., additional, Sunderland, J., additional, Tonge, C., additional, Arumugam, P., additional, Dey, T., additional, Wieczorek, H., additional, Bippus, R., additional, Romijn, R. L., additional, Backus, B. E., additional, Aach, T., additional, Lomsky, M., additional, Johansson, L., additional, Marving, J., additional, Svensson, S., additional, Pou, J. L., additional, Esteves, F. P., additional, Raggi, P., additional, Folks, R., additional, Keidar, Z., additional, Askew, J. W., additional, Verdes, L., additional, Campos, L., additional, Gulyaev, V., additional, Pankova, A., additional, Santos, J., additional, Carmona, S., additional, Henriksson, I., additional, Prata, A., additional, Carrageta, M., additional, Santos, A. I., additional, Yoshinaga, K., additional, Naya, M., additional, Katoh, C., additional, Manabe, O., additional, Yamada, S., additional, Iwano, H., additional, Chiba, S., additional, Tsutsui, H., additional, Tamaki, N., additional, Vassiliadis, I., additional, Despotopoulos, E., additional, Kaitozis, O., additional, Hatzistamatiou, E., additional, Thompson, R., additional, Hatch, J., additional, Zink, M., additional, Gu, B. S., additional, Bae, G. D., additional, Dae, C. M., additional, Min, G. H., additional, Chun, E. J., additional, Choi, S. I., additional, Al-Mallah, M., additional, Kassem, K., additional, Khawaja, O., additional, Goodman, D., additional, Lipkin, D., additional, Christiaens, L., additional, Bonnet, B., additional, Mergy, J., additional, Coisne, D., additional, Allal, J., additional, Dias Ferreira, N., additional, Leite, D., additional, Rocha, J., additional, Carvalho, M., additional, Caeiro, D., additional, Bettencourt, N., additional, Braga, P., additional, Gama Ribeiro, V., additional, Kristoffersen, U. S., additional, Lebech, A. M., additional, Gutte, H., additional, Ripa, R. S., additional, Wiinberg, N., additional, Petersen, C. L., additional, Jensen, G., additional, Kjaer, A., additional, Bai, C., additional, Conwell, R., additional, Folks, R. D., additional, Verdes-Moreiras, L., additional, Manatunga, D., additional, Jacobson, A. F., additional, Belzer, D., additional, Hasid, Y., additional, Rehling, M., additional, Poulsen, R. H., additional, Falborg, L., additional, Rasmussen, J. T., additional, Waehrens, L. N., additional, Heegaard, C. W., additional, Silvola, J. M. U., additional, Forsback, S., additional, Laine, J. O., additional, Heinonen, S., additional, Ylaherttuala, S., additional, Broisat, A., additional, Ruiz, M., additional, Goodman, N. C., additional, Dimastromatteo, J., additional, Glover, D. K., additional, Hyafil, F., additional, Blackwell, F., additional, Pavon-Djavid, G., additional, Sarda-Mantel, L., additional, Feldman, L. J., additional, Meddahi-Pelle, A., additional, Tsatkin, V., additional, Liu, Y.- H., additional, De Kemp, R., additional, Slomka, P. J., additional, Klein, R., additional, Germano, G., additional, Beanlands, R. S., additional, Rohani, A., additional, Akbari, V., additional, Groothuis, J. G. J., additional, Fransen, M., additional, Beek, A. M., additional, Brinckman, S. L., additional, Meijerink, M. R., additional, Hofman, M. B. M., additional, Van Kuijk, C., additional, Kogure, S., additional, Yamashita, E., additional, Murakami, J., additional, Kawaguchi, R., additional, Adachi, H., additional, Oshima, S., additional, Minin, S., additional, Popov, S., additional, Saushkina, Y. U., additional, Savenkova, G., additional, Lebedev, D., additional, Alexandridis, E., additional, Rovithis, D., additional, Parisis, C., additional, Sazonova, I., additional, Saushkin, V., additional, Chernov, V., additional, Zaabar, L., additional, Bahri, H., additional, Hadj Ali, S., additional, Sellem, A., additional, Slim, I., additional, El Kadri, N., additional, Slimen, H., additional, Hammami, H., additional, Lucic, S., additional, Peter, A., additional, Tadic, S., additional, Nikoletic, K., additional, Jung, R., additional, Lucic, M., additional, Tagil, K., additional, Jakobsson, D., additional, Svensson, S.- E., additional, Wollmer, P., additional, Leccisotti, L., additional, Indovina, L., additional, Paraggio, L., additional, Calcagni, M. L., additional, Giordano, A., additional, Kapitan, M., additional, Paolino, A., additional, Nunez, M., additional, Sweeny, J., additional, Kulkarni, N., additional, Guma, K., additional, Akashi, Y., additional, Takano, M., additional, Takai, M., additional, Koh, S., additional, Miyake, F., additional, Torun, N., additional, Durmus Altun, G., additional, Altun, A., additional, Kaya, E., additional, Saglam, H., additional, Matsuoka, D. T., additional, Sanchez, A., additional, Bartolozzi, C., additional, Padua, D., additional, Ponta, G., additional, Ponte, A., additional, Carneiro, A., additional, Thom, A., additional, Ashrafi, R., additional, Garg, P., additional, Davis, G., additional, Falcao, A., additional, Costa, M., additional, Bussolini, F., additional, Meneghetti, J. A. C., additional, Tobisaka, M., additional, Correia, E., additional, Jansen, J. W., additional, Van Der Vleuten, P. A., additional, Willems, T. P., additional, Zijlstra, F., additional, Sato, M., additional, Taniguchi, K., additional, Kurabayashi, M., additional, Pop Gjorcheva, D., additional, Zdraveska-Kochovska, M., additional, Moriwaki, K., additional, Kawamura, A., additional, Watanabe, K., additional, Omura, T., additional, Sakabe, S., additional, Seko, T., additional, Kasai, A., additional, Ito, M., additional, Obana, M., additional, Akasaka, T., additional, Hruska, C., additional, Truong, D., additional, Pletta, C., additional, Collins, D., additional, Tortorelli, C., additional, Rhodes, D., additional, El-Prince, M., additional, Martinez-Moeller, A., additional, Marinelli, M., additional, Weismueller, S., additional, Hillerer, C., additional, Jensen, B., additional, Nekolla, S. G., additional, Wakabayashi, H., additional, Tsukamoto, K., additional, Baker, S. M. E. A., additional, Sirajul Haque, K. M. H. S., additional, Siddique, A., additional, Krishna Banarjee, S., additional, Ahsan, A., additional, Rahman, F., additional, Mukhlesur Rahman, M., additional, Parveen, T., additional, Lutfinnessa, M., additional, Nasreen, F., additional, Sano, H., additional, Naito, S., additional, De Rimini, M. L., additional, Borrelli, G., additional, Baldascino, F., additional, Calabro, P., additional, Maiello, C., additional, Russo, A., additional, Amarelli, C., additional, Muto, P., additional, Danad, I., additional, Raijmakers, P. G., additional, Appelman, Y. E., additional, Hoekstra, O. S., additional, Marcus, J. T., additional, Boonstra, A., additional, Ryzhkova, D. V., additional, Kuzmina, T. V., additional, Borodina, O. S., additional, Trukshina, M. A., additional, Kostina, I. S., additional, Hommel, H., additional, Feuchtner, G., additional, Pachinger, O., additional, Friedrich, G., additional, Stel, A. M., additional, Deckers, J. W., additional, Gama, V., additional, Ciarka, A., additional, Neefjes, L. A., additional, Mollet, N. R., additional, Sijbrands, E. J., additional, Wilczek, J., additional, Llibre Pallares, C., additional, Abdul-Jawad Altisent, O., additional, Cuellar Calabria, H., additional, Mahia Casado, P., additional, Gonzalez-Alujas, M. T., additional, Evangelista Masip, A., additional, Garcia-Dorado Garcia, D., additional, Tekabe, Y., additional, Shen, X., additional, Li, Q., additional, Luma, J., additional, Weisenberger, D., additional, Schmidt, A. M., additional, Haubner, R., additional, Johnson, L., additional, Sleiman, L., additional, Thorn, S., additional, Hasu, M., additional, Thabet, M., additional, Dasilva, J. N., additional, Whitman, S. C., additional, Genovesi, D., additional, Giorgetti, A., additional, Gimelli, A., additional, Cannizzaro, G., additional, Bertagna, F., additional, Fagioli, G., additional, Rossi, M., additional, Bonini, R., additional, Marzullo, P., additional, Paterson, C. A., additional, Smith, S. A., additional, Small, A. D., additional, Goodfield, N. E. R., additional, Martin, W., additional, Nekolla, S., additional, Sherif, H., additional, Reder, S., additional, Yu, M., additional, Kusch, A., additional, Li, D., additional, Zou, J., additional, Lloyd, M. S., additional, Cao, K., additional, Motherwell, D. W., additional, Rice, A., additional, Mccurrach, G. M., additional, Cobbe, S. M., additional, Petrie, M. C., additional, Al Younis, I., additional, Van Der Wall, E., additional, Mirza, T., additional, Raza, M., additional, Hashemizadeh, H., additional, Santos, L., additional, Krishna, B. A., additional, Perna, F., additional, Lago, M., additional, Leo, M., additional, Pelargonio, G., additional, Bencardino, G., additional, Narducci, M. L., additional, Casella, M., additional, Bellocci, F., additional, Kirac, S., additional, Yaylali, O., additional, Serteser, M., additional, Yaylali, T., additional, Okizaki, A., additional, Urano, Y., additional, Nakayama, M., additional, Ishitoya, S., additional, Sato, J., additional, Ishikawa, Y., additional, Sakaguchi, M., additional, Nakagami, N., additional, Aburano, T., additional, Solav, S. V., additional, Bhandari, R., additional, Burrell, S., additional, Dorbala, S., additional, Bruno, I., additional, Caldarella, C., additional, Collarino, A., additional, Mattoli, M. V., additional, Stefanelli, A., additional, Cannarile, A., additional, Maggi, F., additional, Soukhov, V., additional, Bondarev, S., additional, Yalfimov, A., additional, Khan, M., additional, Priyadharshan, P. P., additional, Chandok, G., additional, Aziz, T., additional, Avison, M., additional, Smith, R. A., additional, Bulugahapitya, D. S., additional, Vakhtangadze, T., additional, Todua, F., additional, Baramia, M., additional, Antelava, G., additional, Roche, N.- C., additional, Paule, P., additional, Kerebel, S., additional, Gil, J.- M., additional, Fourcade, L., additional, Tzonevska, A., additional, Tzvetkov, K., additional, Atanasova, M., additional, Parvanova, V., additional, Chakarova, A., additional, Piperkova, E., additional, Kocabas, B., additional, Muderrisoglu, H., additional, Allaart, C. P., additional, Entok, E., additional, Simsek, S., additional, Akcay, B., additional, Ak, I., additional, Vardareli, E., additional, Stachura, M., additional, Kwasiborski, P. J., additional, Horszczaruk, G. J., additional, Komar, E., additional, Cwetsch, A., additional, Zraik, B., additional, Morales Demori, R., additional, Almeida, A. D. J., additional, Siqueira, M. E., additional, Vieira, E., additional, Balogh, I., additional, Kerecsen, G., additional, Marosi, E., additional, Szelid, Z. S., additional, Sattar, A., additional, Swadia, T., additional, Chattahi, J., additional, Qureshi, W., additional, Khalid, F., additional, Gonzalez, A., additional, Hechavarria, S., additional, Takamura, K., additional, Fujimoto, S., additional, Nakanishi, R., additional, Yamashina, S., additional, Namiki, A., additional, Yamazaki, J., additional, Koshino, K., additional, Hashikawa, Y., additional, Teramoto, N., additional, Hikake, M., additional, Ishikane, S., additional, Ikeda, T., additional, Iida, H., additional, Takahashi, Y., additional, Oriuchi, N., additional, Higashino, H., additional, Endo, K., additional, Mochizuki, T., additional, Murase, K., additional, Baali, A., additional, Moreno, R., additional, Chau, M., additional, Rousseau, H., additional, Nicoud, F., additional, Dolliner, P., additional, Brammen, L., additional, Steurer, G., additional, Traub-Weidinger, T., additional, Ubl, P., additional, Schaffarich, P., additional, Dobrozemsky, G., additional, Staudenherz, A., additional, Ozgen Kiratli, M., additional, Temelli, B., additional, Kanat, N. B., additional, Aksoy, T., additional, Slavich, G. A., additional, Piccoli, G., additional, Puppato, M., additional, Grillone, S., additional, Gasparini, D., additional, Dunet, V., additional, Perruchoud, S., additional, Poitry-Yamate, C., additional, Lepore, M., additional, Gruetter, R., additional, Pedrazzini, T., additional, Anselm, D., additional, Anselm, A., additional, Atkins, H., additional, Renaud, J., additional, Dekemp, R., additional, Burwash, I., additional, Guo, A., additional, Beanlands, R., additional, Glover, C., additional, Vilardi, I., additional, Zangheri, B., additional, Calabrese, L., additional, Romano, P., additional, Bruno, A., additional, Fernandez Cimadevilla, O. C., additional, Uusitalo, V. A., additional, Luotolahti, M., additional, Wendelin-Saarenhovi, M., additional, Sundell, J., additional, Raitakari, O., additional, Huidu, S., additional, Gadiraju, R., additional, Ghesani, M., additional, Uddin, Q., additional, Wosnitzer, B., additional, Takahashi, N., additional, Alhaj, E., additional, Legasto, A., additional, Abiri, B., additional, Elsaban, K., additional, El Khouly, T., additional, El Kammash, T., additional, Al Ghamdi, A., additional, Kyung Deok, B., additional, Bon Seung, K., additional, Sang Geun, Y., additional, Chang Min, D., additional, and Gwan Hong, M., additional

Published
2011
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11. Imaging of coronary atherosclerosis and identification of the vulnerable plaque

Author

Pj, Feyter, Pw, Serruys, Nieman K, Mollet N, Filippo Cademartiri, Rj, Geuns, Slager C, Af, Steen, Krams R, Ja, Schaar, Wielopolski P, Pm, Pattynama, Arampatzis A, van der Lugt A, Regar E, Ligthart J, and Smits P

Subjects
Review Article
Abstract

Identification of the vulnerable plaque responsible for the occurrence of acute coronary syndromes and acute coronary death is a prerequisite for the stabilisation of this vulnerable plaque. Comprehensive coronary atherosclerosis imaging in clinical practice should involve visualisation of the entire coronary artery tree and characterisation of the plaque, including the three-dimensional morphology of the plaque, encroachment of the plaque on the vessel lumen, the major tissue components of the plaque, remodelling of the vessel and presence of inflammation. Obviously, no single diagnostic modality is available that provides such comprehensive imaging and unfortunately no diagnostic tool is available that unequivocally identifies the vulnerable plaque. The objective of this article is to discuss experience with currently available diagnostic modalities for coronary atherosclerosis imaging. In addition, a number of evolving techniques will be briefly discussed.

Published
2003

13. A patient-specific visualization tool for comprehensive analysis of coronary CTA and perfusion MRI data

Author

Kirisli, H.A. (author), Gupta, V. (author), Kirschbaum, S. (author), Neefjes, L. (author), Van Geuns, R.J. (author), Mollet, N. (author), Lelieveldt, B.P.F. (author), Reiber, J.H.C. (author), Van Walsum, T. (author), Niessen, W.J. (author), Kirisli, H.A. (author), Gupta, V. (author), Kirschbaum, S. (author), Neefjes, L. (author), Van Geuns, R.J. (author), Mollet, N. (author), Lelieveldt, B.P.F. (author), Reiber, J.H.C. (author), Van Walsum, T. (author), and Niessen, W.J. (author)

Abstract

Cardiac magnetic resonance perfusion imaging (CMR) and computed tomography angiography (CTA) are widely used to assess heart disease. CMR is used to measure the global and regional myocardial function and to evaluate the presence of ischemia; CTA is used for diagnosing coronary artery disease, such as coronary stenoses. Nowadays, the hemodynamic significance of coronary artery stenoses is determined subjectively by combining information on myocardial function with assumptions on coronary artery territories. As the anatomy of coronary arteries varies greatly between individuals, we developed a patient-specific tool for relating CTA and perfusion CMR data. The anatomical and functional information extracted from CTA and CMR data are combined into a single frame of reference. Our graphical user interface provides various options for visualization. In addition to the standard perfusion Bull’s Eye Plot (BEP), it is possible to overlay a 2D projection of the coronary tree on the BEP, to add a 3D coronary tree model and to add a 3D heart model. The perfusion BEP, the 3D-models and the CTA data are also interactively linked. Using the CMR and CTA data of 14 patients, our tool directly established a spatial correspondence between diseased coronary artery segments and myocardial regions with abnormal perfusion. The location of coronary stenoses and perfusion abnormalities were visualized jointly in 3D, thereby facilitating the study of the relationship between the anatomic causes of a blocked artery and the physiological effects on the myocardial perfusion. This tool is expected to improve diagnosis and therapy planning of early-stage coronary artery disease., Intelligent Systems, Electrical Engineering, Mathematics and Computer Science

Published
2011
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14. A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension

Author

Genders, T S S, Steyerberg, E W, Alkadhi, H, Leschka, S, Desbiolles, L, Nieman, K, Galema, T W, Meijboom, W B, Mollet, N R, de Feyter, P J, Cademartiri, F, Maffei, E, Dewey, M, Zimmermann, E, Laule, M, Pugliese, F, Barbagallo, R, Sinitsyn, V, Bogaert, J, Goetschalckx, K, Rowe, G W, Schoepf, U J, Schuijf, J D, Bax, J J, de Graaf, F R, Knuuti, J, Kajander, S, van Mieghem, C A G, Meijs, M F L, Cramer, M J, Gopalan, D, Feuchtner, G, Friedrich, G, Krestin, G P, Hunink, M G M, Genders, T S S, Steyerberg, E W, Alkadhi, H, Leschka, S, Desbiolles, L, Nieman, K, Galema, T W, Meijboom, W B, Mollet, N R, de Feyter, P J, Cademartiri, F, Maffei, E, Dewey, M, Zimmermann, E, Laule, M, Pugliese, F, Barbagallo, R, Sinitsyn, V, Bogaert, J, Goetschalckx, K, Rowe, G W, Schoepf, U J, Schuijf, J D, Bax, J J, de Graaf, F R, Knuuti, J, Kajander, S, van Mieghem, C A G, Meijs, M F L, Cramer, M J, Gopalan, D, Feuchtner, G, Friedrich, G, Krestin, G P, and Hunink, M G M

Abstract

Aims The aim was to validate, update, and extend the Diamond-Forrester model for estimating the probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Methods and results Prospectively collected data from 14 hospitals on patients with chest pain without a history of CAD and referred for conventional coronary angiography (CCA) were used. Primary outcome was obstructive CAD, defined as ≥50% stenosis in one or more vessels on CCA. The validity of the Diamond-Forrester model was assessed using calibration plots, calibration-in-the-large, and recalibration in logistic regression. The model was subsequently updated and extended by revising the predictive value of age, sex, and type of chest pain. Diagnostic performance was assessed by calculating the area under the receiver operating characteristic curve (c-statistic) and reclassification was determined. We included 2260 patients, of whom 1319 had obstructive CAD on CCA. Validation demonstrated an overestimation of the CAD probability, especially in women. The updated and extended models demonstrated a c-statistic of 0.79 (95% CI 0.77-0.81) and 0.82 (95% CI 0.80-0.84), respectively. Sixteen per cent of men and 64% of women were correctly reclassified. The predicted probability of obstructive CAD ranged from 10% for 50-year-old females with non-specific chest pain to 91% for 80-year-old males with typical chest pain. Predictions varied across hospitals due to differences in disease prevalence. Conclusion Our results suggest that the Diamond-Forrester model overestimates the probability of CAD especially in women. We updated the predictive effects of age, sex, type of chest pain, and hospital setting which improved model performance and we extended it to include patients of 70 years and older.

Published
2011

15. Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve

Author

Rossi, A., primary, Uitterdijk, A., additional, Dijkshoorn, M., additional, Klotz, E., additional, Dharampal, A., additional, van Straten, M., additional, van der Giessen, W. J., additional, Mollet, N., additional, van Geuns, R.-J., additional, Krestin, G. P., additional, Duncker, D. J., additional, de Feyter, P. J., additional, and Merkus, D., additional

Published
2012
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16. Regression-Based Cardiac Motion Prediction From Single-Phase CTA

Author

Metz, C. T., primary, Baka, N., additional, Kirisli, H., additional, Schaap, M., additional, Klein, S., additional, Neefjes, L. A., additional, Mollet, N. R., additional, Lelieveldt, B., additional, de Bruijne, M., additional, Niessen, W. J., additional, and van Walsum, T., additional

Published
2012
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22. Non-invasive coronary angiography with 64-slice computed tomography

Author

Filippo Cademartiri, Malagutti, P., Belgrano, M., Runza, G., Pugliese, F., Mollet, N. R., Meijboom, W. B., Krestin, G. P., Peyter, P. J., Cademartiri, F., Malagutti, P., Belgrano, MANUEL GIANVALERIO, Runza, G., Pugliese, F., Mollet, N. R., Meijboom, W. B., Krestin, G. P., and De Feyter, P. J.

Subjects
Humans, Coronary Artery Disease, Coronary Angiography, Tomography, X-Ray Computed
Abstract

Multislice computed tomography is a rapidly emerging technique for the non-invasive visualization of coronary arteries. Over the past 5 years several scanner generation were introduced with a progressive improvement in the diagnostic accuracy in the detection of coronary artery stenosis in selected patients populations. The introduction of 64-slice technology has further improved the diagnostic performance. This technique is at the edge of clinical implementation and, even though large clinical trials are still missing, an increased demand for these type of studies is observed all over the world. We describe our experience of more than 1 year with 64-slice CT coronary angiography providing clues on reasonable clinical applications.

23. Computed tomography coronary angiography vs. stress ECG in patients with stable angina

Author

Massimo Midiri, Ludovico La Grutta, Manuel Belgrano, Annick C. Weustink, Nico R. Mollet, Chiara Martini, Sara Seitun, Maria Assunta Cova, Alessandro Palumbo, F. Coppolino, Roberto Malago, Filippo Cademartiri, Erica Maffei, Annachiara Aldrovandi, Cademartiri, F., La Grutta, L., Palumbo, A., Maffei, E., Martini, C., Seitun, S., Coppolino, F., Belgrano, MANUEL GIANVALERIO, Malago, R., Aldrovandi, A., Mollet, N., Weustink, A., Cova, MARIA ASSUNTA, Midiri, M., Radiology & Nuclear Medicine, Cademartiri, F, La Grutta, L, Palumbo, A, Maffei, E, Martini, C, Seitun, S, Coppolino, F, Belgrano, M, Malagò, R, Aldrovandi, A, Mollet, N, Weustink, A, Cova, M, and Midiri, M

Subjects
Male, Coronary angiography, stable angina, medicine.medical_specialty, Exercise test, Coronary artery disease, Angina Pectoris, Imaging, Electrocardiography, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Computed tomography, Aged, Neuroradiology, medicine.diagnostic_test, business.industry, Imaging, Coronary artery disease, Computed tomography, Coronary angiography, Exercise test, Ultrasound, Interventional radiology, General Medicine, Middle Aged, medicine.disease, Predictive value of tests, Cardiology, Female, Radiology, Tomography, X-Ray Computed, business, stress ECG, Algorithms, Stress Electrocardiography
Abstract

PURPOSE: This study compared the role of multislice computed tomography coronary angiography (MSCT-CA) and stress electrocardiography (ECG) in the diagnostic workup of patients with chronic chest pain. MATERIALS AND METHODS: MSCT-CA was performed in 43 patients (31 men, 12 women, mean age 58.8+/-7.7 years) with stable angina after a routine diagnostic workup involving stress ECG and conventional CA. The following inclusion criteria were adopted: sinus rhythm and ability to hold breath for 12 s. Beta-blockers were administered in patients with heart rate>or=70 beats/minute. In order to identify or exclude patients with significant stenoses (>or=50% lumen), we determined posttest likelihood ratios of stress test and MSCT-CA separately and of MSCT-CA performed after the stress test. RESULTS: The pretest probability of significant coronary artery disease (CAD) was 74%. Positive and negative likelihood ratios were 2.3 [95% confidence interval (CI) 1.0-5.3] and 0.3 (95% CI: 0.2-0.7) for the stress test and 10.0 (95% CI: 1.8-78.4) and 0.0 (95% CI: 0.0-infinity) for MSCT-CA, respectively. MSCT-CA increased the posttest probability of significant CAD after a negative stress test from 50% to 86% and after a positive stress test from 88% to 100%. MSCT-CA correctly detected all patients without CAD. CONCLUSIONS: Noninvasive MSCT-CA is a potentially useful tool in the diagnostic workup of patients with stable angina owing to its capability to detect or exclude significant CAD.

Published
2009

24. Noninvasive evaluation of the celiac trunk and superior mesenteric artery with multislice CT in patients with chronic mesenteric ischaemia

Author

Chiara Martini, Massimo Midiri, Girolamo Crisi, Roberto Malago, Manuel Belgrano, Erica Maffei, Ludovico La Grutta, Tommaso Vincenzo Bartolotta, Giacomo Luccichenti, Rolf Raaijmakers, Maurizio Zompatori, Alessandro Palumbo, Filippo Cademartiri, Nico R. Mollet, Radiology & Nuclear Medicine, Cademartiri F., Palumbo A., Maffei E., Martini C., Malagò R., Belgrano M., La Grutta L., Bartolotta T., Luccichenti G., Midiri M., Raaijmakers R., Mollet N., Zompatori M., Crisi G., Cademartiri, F., Palumbo, A., Maffei, E., Martini, C., Malago, R., Belgrano, MANUEL GIANVALERIO, La Grutta, L., Bartolotta, T. V., Luccichenti, G., Midiri, M., Raaijmakers, R., Mollet, N., Zompatori, M., Crisi, G., CADEMARTIRI F, PALUMBO A, MAFFEI E, MARTINI C, MALAGÒ R, BELGRANO M, LA GRUTTA L, BARTOLOTTA TV, LUCCICHENTI G, MIDIRI M, RAAIJMAKERS R, MOLLET N, ZOMPATORI M, and CRISI G

Subjects
Chronic mesenteric ischaemia, Adult, Male, medicine.medical_specialty, chemical and pharmacologic phenomena, complex mixtures, Abdominal angina, Celiac Artery, Ischemia, Mesenteric Artery, Superior, medicine.artery, parasitic diseases, MSCT angiography, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Mesentery, cardiovascular diseases, Superior mesenteric artery, MSCT angiography, Chronic mesenteric ischaemia, Abdominal angina, Neuroradiology, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Ultrasound, Angiography, nutritional and metabolic diseases, Interventional radiology, General Medicine, Middle Aged, bacterial infections and mycoses, Trunk, digestive system diseases, surgical procedures, operative, cardiovascular system, Female, Radiology, COMPUTED TOMOGRAPHY, medicine.symptom, business, Tomography, X-Ray Computed, therapeutics
Abstract

This study sought to assess the role of multislice computed tomography (MSCT) in patients with suspected chronic mesenteric ischaemia (CMI). Forty-five patients (29 men; mean age 68) underwent MSCT angiography of the abdomen for suspected CMI (main clinical finding: postprandial abdominal pain). The scan protocol was detectors/collimation 16/0.75 mm; feed 36 mm/s; rotation time 500 ms; increment 0.4 mm; 120-150 mAs and 120 kVp. A volume of 80 ml of contrast material was administered through an antecubital vein (rate 4 ml/s), followed by 40 ml of saline (rate 4 ml/s). Images were analysed on the workstation with different algorithms (axial image scrolling, multiplanar reconstructions, maximum intensity projection, volume rendering). Targeted central lumen-line reconstructions (curved reconstructions) were obtained along the celiac trunk (CeT) and superior mesenteric artery (SMA). Vessel occlusions and significant (> 50%) stenosis were recorded. Image generation and interpretation required 25 min. Stenosis and/or occlusions were detected in 29 (65%) cases on the CeT and in 32 (71%) on the SMA. Of those lesions (n=61), 44 (49%) were classified as not significant. In 16 (35%) cases, there was a simultaneous stenosis and/or occlusion of the CeT and SMA (confirmed by conventional angiography). In six (13%) cases, there were no lesions affecting the CeT, SMA or their branches (confirmed by clinical follow-up). MSCT angiography can play a major role in the detection of stenosis of the abdominal arteries in patients with suspected CMI

Published
2008

25. Prognostic value of Morise clinical score, calcium score and computed tomography coronary angiography in patients with suspected or known coronary artery disease

Author

Massimo Midiri, Carlo Tedeschi, Nico R. Mollet, R. De Rosa, Annick C. Weustink, Erica Maffei, Sara Seitun, E. Emiliano, Onofrio A. Catalano, Roberto Malago, Annachiara Aldrovandi, Ludovico La Grutta, Chiara Martini, A. Cuttone, A. Palumbo, Filippo Cademartiri, Radiology & Nuclear Medicine, Cardiology, Maffei, E, Seitun, S, Palumbo, A, Martini, C, Emiliano, E, Cuttone, A, Aldrovandi, A, Malagò, R, La Grutta, L, Midiri, M, Tedeschi, C, De Rosa, R, Catalano, O, Weustink, A, Mollet, N, and Cademartiri, F

Subjects
Coronary angiography, Male, medicine.medical_specialty, Coronary Artery Disease, Coronary Angiography, Morise score, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, Computed tomography coronary angiography, Coronary artery disease, SDG 3 - Good Health and Well-being, Predictive Value of Tests, Risk Factors, Internal medicine, Severity of illness, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Survival analysis, Neuroradiology, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Calcinosis, Retrospective cohort study, Interventional radiology, General Medicine, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Calcium score, Computed tomography coronary angiography, Prognostic value, Prognosis, Calcium score, Morise score, Predictive value of tests, Cardiology, Female, Radiology, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, business, Tomography, X-Ray Computed, Prognostic value, CARDIAC CT, Algorithms, Follow-Up Studies
Abstract

Our aim was to determine the prognostic value of computed tomography coronary angiography (CTCA), coronary artery calcium scoring (CACS) and Morise clinical score in patients with known or suspected coronary artery disease (CAD). A total of 722 patients (480 men; 62.7 +/- 10.9 years) who were referred for further cardiac evaluation underwent CACS and contrast-enhanced CTCA to evaluate the presence and severity of CAD. Of these, 511 (71%) patients were without previous history of CAD. Patients were stratified according to the Morise clinical score (low, intermediate, high), to CACS (0-10, 11-100, 101-400, 401-1,000, > 1,000) and to CTCA (absence of CAD, nonsignificant CAD, obstructive CAD). Patients were followed up for the occurrence of major events: cardiac death, nonfatal myocardial infarction, unstable angina and revascularisation. Significant CAD (> 50% luminal narrowing) was detected in 260 (36%) patients; nonsignificant CAD (< 50% luminal narrowing) in 250 (35%) and absence of CAD in 212 (29%). During a mean follow-up of 20 +/- 4 months, 116 events (21 hard) occurred. In patients with normal coronary arteries on CTCA, the major event rate was 0% vs. 1.7% in patients with nonsignificant CAD and 7.3% in patients with significant CAD (p < 0.0001). Three hard events (14%) occurred in patients with CACSa parts per thousand currency sign100 and two (9.5%) in patients with intermediate Morise score; one revascularisation was observed in a patient with low Morise score. At multivariate analysis, diabetes, obstructive CAD and CACS > 1,000 were significant predictors of events (p < 0.05). An excellent prognosis was noted in patients with a normal CTCA (0% event rate). CACS a parts per thousand currency sign100 and low-intermediate Morise score did not exclude the possibility of events at follow-up.

Published
2011

26. Low dose CT of the heart: a quantum leap into a new era of cardiovascular imaging

Author

Sara Seitun, Filippo Cademartiri, Ludovico La Grutta, Alberto Clemente, Nico R. Mollet, S. de Crescenzo, Carlo Tedeschi, Ermanno Capuano, A. Igoren Guaricci, Adriano Rossi, Chiara Martini, Erica Maffei, Roberto Malago, Annick C. Weustink, Teresa Arcadi, Maffei, E, Martini, C, De Crescenzo, S, Arcadi, T, Clemente, A, Capuano, E, Rossi, A, Malagò, R, Mollet, N, Weustink, A, Tedeschi, C, La Grutta, L, Seitun, S, Guaricci Igoren, A, Cademartiri, F, Radiology & Nuclear Medicine, and Cardiology

Subjects
Coronary angiography, medicine.medical_specialty, Cardiology, Computed tomography, cardiac CT, Coronary Disease, Coronary Angiography, Radiation Dosage, Coronary artery disease, Computed tomography coronary angiography, medicine, Training, Low dose ct, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Neuroradiology, medicine.diagnostic_test, Equipment Safety, business.industry, Radiation dose, General Medicine, Conventional coronary angiography, medicine.disease, Computed tomography coronary angiography, Conventional coronary angiography, Coronary artery disease, Radiation dose, Training, Clinical reality, Safety Equipment, business, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, Radiology, Tomography, X-Ray Computed
Abstract

In 10 years, computed tomography coronary angiography (CTCA) has shifted from an investigational tool to clinical reality. Even though CT technologies are very advanced and widely available, a large body of evidence supporting the clinical role of CTCA is missing. The reason is that the speed of technological development has outpaced the ability of the scientific community to demonstrate the clinical utility of the technique. In addition, with each new CT generation, there is a further broadening of actual and potential applications. In this review we examine the state of the art on CTCA. In particular, we focus on issues concerning technological development, radiation dose, implementation, training and organisation.

Published
2009

27. Diagnostic accuracy of multislice computed tomography coronary angiography is improved at low heart rates

Author

Massimo Midiri, Pim J. de Feyter, Patrizia Malagutti, Manuel Belgrano, Filippo Cademartiri, Giuseppe Runza, Bob Meijboom, Nico R. Mollet, Gabriel P. Krestin, Radiology & Nuclear Medicine, Cardiology, Cademartiri, F., Mollet, N. R., Runza, G., Belgrano, MANUEL GIANVALERIO, Malagutti, P., Meijboom, B. W., Midiri, M., Feyter, P. J., and Krestin, G. P.

Subjects
Male, medicine.medical_specialty, Population, Contrast Media, Coronary Disease, Nonparametric *Tomography, Coronary Angiography, Statistics, Nonparametric, Chi-Square Distribution Contrast Media Coronary Angiography/*methods Coronary Disease/physiopathology/*radiography Female Heart Rate/*physiology Humans Male Middle Aged Retrospective Studies Statistics, Coronary artery disease, X-Ray Computed Triiodobenzoic Acids/diagnostic use, Heart Rate, Internal medicine, Triiodobenzoic Acids, Heart rate, medicine, Humans, Radiology, Nuclear Medicine and imaging, Bolus tracking, education, Cardiac imaging, Retrospective Studies, education.field_of_study, Chi-Square Distribution, business.industry, Middle Aged, medicine.disease, Iodixanol, Stenosis, Cardiology, Chi-Square Distribution Contrast Media Coronary Angiography/*methods Coronary Disease/physiopathology/*radiography Female Heart Rate/*physiology Humans Male Middle Aged Retrospective Studies Statistic, Female, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Chi-squared distribution, medicine.drug
Abstract

PURPOSE: Assess the effect of heart rate on diagnostic accuracy for the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). MATERIAL AND METHODS: About 120 patients (105 males; 59+/-11 years) with suspected coronary artery disease who underwent conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. Patients underwent a MSCT-CA (Sensation 16, Siemens, Germany), with the following protocol: collimation 16 x 0.75 mm, gantry rotation time 420 ms, feed/rotation 3.0 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of Iodixanol (Visipaque 320 mg l/ml, Amersham, UK) at 4 ml/s and the delay was defined with a bolus tracking technique. In all patients the mean heart rate (HR) during the scan was used as a criteria to divide the population in two groups of 60 patients each. In one group (Low HR) the 60 patients with lower heart rates, and in the other group (High HR) the patients with higher heart rates. In the two groups diagnostic accuracy (per coronary segment) for the detection of significant stenosis (>or=50% lumen reduction) was evaluated in vessels >or=2 mm of diameter using quantitative CA as reference standard. The difference in diagnostic accuracy were compared with a Chi(2) test and a p

Published
2005

28. Introduction to coronary imaging with 64-slice computed tomography

Author

Filippo Cademartiri, Runza G, Belgrano M, Luccichenti G, Nr, Mollet, Malagutti P, Silvestrini M, Midiri M, Cova M, Pozzi Mucelli R, Gp, Krestin, CADEMARTIRI F, RUNZA G, BELGRANO M, LUCCICHENTI G, MOLLET NR, MALAGUTTI P, SILVESTRINI M, MIDIRI M, COVA M, POZZI MUCELLI R, KRESTIN GP, Cademartiri, F., Runza, G., Belgrano, MANUEL GIANVALERIO, Luccichenti, G., Mollet, N. R., Malagutti, P., Silvestrini, M., Midiri, M., Cova, MARIA ASSUNTA, Pozzi Mucelli, R., Krestin, G. P., and Radiology & Nuclear Medicine

Subjects
Time Factors, Imaging Sensitivity and Specificity Stents Time Factors Tomography, Contrast Media, Sensitivity and Specificity, 64-row CT, Electrocardiography, Heart Rate, Spiral Computed Tomography, Image Processing, Computer-Assisted, Humans, technical improvements, Coronary Artery Bypass, Phantoms, Imaging, Patient Selection, Algorithms Artifacts Contrast Media Coronary Angiography/instrumentation/*methods Coronary Artery Bypass Coronary Stenosis/*radiography Electrocardiography Heart Rate Humans Image Processing, Computer-Assisted Patient Selection Phantoms, X-Ray Computed/instrumentation/*methods, Coronary Stenosis, coronary angiography, Computer-Assisted Patient Selection Phantom, Stents, Artifacts, Tomography, X-Ray Computed, Tomography, Spiral Computed, Algorithms
Abstract

The aim of this article is to illustrate the main technical improvements in the last generation of 64-row CT scanners and the possible applications in coronary angiography. In particular, we describe the new physical components (X-ray tube-detectors system) and the general scan and reconstruction parameters. We then define the scan protocols for coronary angiography with the new generation of 64-row CT scanners to enable radiologists to perform a CT study on the basis of the diagnostic possibilities.

Published
2005

29. Collateral non cardiac findings in clinical routine CT coronary angiography: results from a multi-center registry

Author

Roberto Lagalla, Filippo Cademartiri, Alberto Clemente, Teresa Arcadi, Nico R. Mollet, Erica Maffei, Alessandra Zuccarelli, Roberto Pozzi Mucelli, Camilla Barbiani, Massimo Midiri, Roberto Malago, Andrea Pezzato, Gabriel P. Krestin, Chiara Martini, Ludovico La Grutta, Radiology & Nuclear Medicine, La Grutta, L., Malagò, R., Maffei, E., Barbiani, C., Pezzato, A., Martini, C., Arcadi, T., Clemente, A., Mollet, N., Zuccarelli, A., Krestin, G., Lagalla, R., Pozzi Mucelli, R., Cademartiri, F., and Midiri, M.

Subjects
Male, Coronary angiography, medicine.medical_specialty, Computed tomography, Coronary Angiography, Coronary artery disease, Computed tomography coronary angiography, Collateral findings, Computed tomography coronary, angiography, Collateral findings, Coronary artery disease, Non-cardiac findings, medicine, Humans, Radiology, Nuclear Medicine and imaging, Registries, Retrospective Studies, Neuroradiology, medicine.diagnostic_test, Non-cardiac findings, business.industry, Ultrasound, Interventional radiology, General Medicine, Middle Aged, Clinical routine, medicine.disease, Computed tomography coronary angiography, Collateral findings, Coronary artery disease, Non-cardiac findings, Female, Radiology, Tomography, X-Ray Computed, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, business, Follow-Up Studies
Abstract

Purpose: The aim of the study was to evaluate the prevalence of collateral findings detected in computed tomography coronary angiography (CTCA) in a multi-center registry. Materials and methods: We performed a retrospective review of 4303 patients (2719 males, mean age 60.3 ± 10.2 years) undergoing 64-slice CTCA for suspected or known coronary artery disease (CAD) at various academic institutions between 01/2006 and 09/2010. Collateral findings were recorded and scored as: non-significant (no signs of relevant pathology, not necessary to be reported), significant (clear signs of pathology, mandatory to be reported), or major (remarkable pathology, mandatory to be reported and further investigated). Results: We detected 6886 non-cardiac findings (1.6 non cardiac finding per patient). Considering all centers, only 865/4303 (20.1 %) patients were completely without any additional finding. Overall, 2095 (30.4 %) non-significant, 4486 (65.2 %) significant, and 305 (4.4 %) major findings were detected. Among major findings, primary lung cancer was reported in 21 cases. In every center, most prevalent significant findings were mediastinal lymph nodes >1 cm. In 256 patients, collateral findings were clinically more relevant than coexisting CAD and justified the symptoms of patients. Conclusions: The prevalence of significant and major collateral findings in CTCA is high. Radiologists should carefully evaluate the entire scan volume in each patient.

30. Assessment of left main coronary artery atherosclerotic burden using 64-slice CT coronary angiography: correlation between dimensions and presence of plaques

Author

F. Alberghina, Nico R. Mollet, Francesca Pugliese, Massimo Midiri, Erica Maffei, Alessandro Palumbo, Giuseppe Runza, Manuel Belgrano, W. Bob Meeijboom, Ludovico La Grutta, Annachiara Aldrovandi, Annick C. Weustink, Filippo Cademartiri, Roberto Malago, Cademartiri, F, La Grutta, L, Malagò, R, Alberghina, F, Palumbo, A, Belgrano, M, Maffei, E, Aldrovandi, A, Pugliese, F, Runza, G, Weustink, A, Bob Meeijboom, W, Mollet, NR, Midiri, M, Cademartiri, F., La Grutta, L., Malago, R., Alberghina, F., Palumbo, A., Belgrano, MANUEL GIANVALERIO, Maffei, E., Aldrovandi, A., Pugliese, F., Runza, G., Weustink, A., Bob Meeijboom, W., Mollet, N. R., Midiri, M., and Radiology & Nuclear Medicine

Subjects
Coronary angiography, Male, medicine.medical_specialty, left main coronary, medicine.disease_cause, Coronary Angiography, Coronary artery disease, Internal medicine, medicine, atherosclerotic burden, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Vulnerable plaque, Neuroradiology, medicine.diagnostic_test, business.industry, Ultrasound, Coronary artery disease, Left main coronary artery, Multidetector-row computed tomography, 64-slice CT, Vulnerable plaque, Interventional radiology, General Medicine, Left main coronary artery, Middle Aged, Multidetector-row computed tomography, medicine.disease, medicine.anatomical_structure, Semiquantitative Method, cardiovascular system, Cardiology, Female, 64-slice CT, Radiology, business, Tomography, X-Ray Computed, Artery
Abstract

PURPOSE: The aim of this study was to correlate left main (LM) coronary artery dimensions with the presence of atherosclerosis by multidetector-row computed tomography (MDCT) coronary angiography (CA) and to assess coronary atherosclerotic plaques with a semiquantitative method. MATERIALS AND METHODS: Sixty-two consecutive patients (41 men, mean age 60+/-11) with suspected coronary artery disease underwent 64-MDCT coronary angiography. LM dimensions (length, ostial and bifurcation diameters), quantitative [location, Hounsfield unit (HU) attenuation] and qualitative (composition, shape) analysis of plaques within the LM were performed. All patients underwent conventional CA. RESULTS: Thirty patients (mean age 55+/-10) without plaques in the LM presented the following average dimensions: length 10.6+/-6.1 mm, ostial diameter 5.5+/-0.7 mm, bifurcation diameter 4.9+/-0.9 mm. LM plaques (n=36) were detected in 32 patients (mean age 64+/-10) with the following LM average dimensions: length 11.3+/-4.0 mm, ostial diameter 6.0+/-1.2 mm and bifurcation diameter 6.0+/-1.2 mm. Plaques were calcified (40%, mean attenuation 742+/-191 HU), mixed (43%, mean attenuation 387+/-94 HU) or noncalcified (17%, mean attenuation 56+/-14 HU) and were frequently eccentric (77%). Age was significantly different in the two groups (p

31. Influence of increasing convolution kernel filtering on plaque imaging with multislice CT using an ex-vivo model of coronary angiography

Author

Filippo Cademartiri, Runza G, Nr, Mollet, Luccichenti G, Belgrano M, Somers P, Knaapen M, Verheye S, Bruining N, Hamers R, Midiri M, Pj, Feyter, Gp, Krestin, Cademartiri F, Runza G, Mollet NR, Luccichenti G, Belgrano M, Somers P, Knaapen M, Verheye S, Bruining N, Hamers R, Midiri M, De Feyter PJ, Krestin GP, Radiology & Nuclear Medicine, Cardiology, Cademartiri, F., Runza, G., Mollet, N. R., Luccichenti, G., Belgrano, MANUEL GIANVALERIO, Somers, P., Knaapen, M., Verheye, S., Bruining, N., Hamers, R., Midiri, M., De Feyter, P. J., and Krestin, G. P.

Subjects
Male, Histological Techniques, Coronary Artery Disease, Middle Aged, convolution kernel filtering, Coronary Angiography, Coronary Vessels, Risk Assessment, Data Interpretation, Statistical, Humans, Female, Autopsy, Tomography, X-Ray Computed, Aged
Abstract

PURPOSE: To assess the variability in attenuation of coronary plaques with multislice CT-angiography (MSCT-CA) in an ex-vivo model with varying convolution kernels. MATERIALS AND METHODS: MSCT-CA (Sensation 16, Siemens) was performed in three ex-vivo left coronary arteries after instillation of contrast material solution (Iomeprol 400 mgI/ml, dilution: 1/80). The specimens were placed in oil to simulate epicardial fat. Scan parameters: slices 16/0.75 mm, rotation time 375 ms, feed/rotation 3.0 mm, mAs 500, slice thickness 1 mm, and FOV 50 mm. Datasets were reconstructed using 4 different kernels (B30f-smooth, B36f-medium smooth, B46f-medium, and B60f-sharp). Each scan was scored for the presence of plaques. Once a plaque was detected, the operator performed attenuation measurements (HU) in coronary lumen, oil, calcified and soft plaque tissue using the same settings in all datasets. The results were compared with T-test and correlated with Pearson's test. RESULTS: Overall, 464 measurements were performed. Significant differences (p

32. Impact of intravascular enhancement, heart rate, and calcium score on diagnostic accuracy in multislice computed tomography coronary angiography

Author

Cademartiri F, Runza G, Nr, Mollet, Luccichenti G, Belgrano M, Tv, Bartolotta, Massimo Galia, Midiri M, Pozzi Mucelli R, Gp, Krestin, Cademartiri, F., Runza, G., Mollet, N. R., Luccichenti, G., Belgrano, MANUEL GIANVALERIO, Bartolotta, T. V., Galia, M., Midiri, M., Pozzi Mucelli, R., Krestin, G. P., Radiology & Nuclear Medicine, CADEMARTIRI F, RUNZA G, MOLLET NR, LUCCICHENTI G, BELGRANO M, BARTOLOTTA TV, GALIA M, MIDIRI M, POZZI MUCELLI R, and KRESTIN GP

Subjects
Male, Statistical Female *Heart Rate Humans Male Middle Aged Retrospective Studies Sensitivity and Specificity Tomography, Contrast Media, Coronary Disease, Coronary Artery Disease, Coronary Angiography, Sensitivity and Specificity, Heart Rate, Triiodobenzoic Acids, Humans, coronary artery stenosis, Aged, Retrospective Studies, Body Weight, Coronary Stenosis, Calcinosis, Middle Aged, Aged Artifacts Body Weight Calcinosis/*radiography Contrast Media Coronary Angiography/*methods Coronary Artery Disease/radiography Coronary Disease/*radiography Coronary Stenosis/radiography Data Interpretation, X-Ray Computed/*methods Triiodobenzoic Acids/administration & dosage/diagnostic use, Data Interpretation, Statistical, Female, multislice computed tomography (MSCT), Artifacts, Tomography, X-Ray Computed
Abstract

PURPOSE: To assess the effect of intravascular enhancement, heart rate, and calcium score on diagnostic accuracy in the detection of significant coronary artery stenosis using 16-row multislice computed tomography (MSCT). MATERIALS AND METHODS: One hundred patients (88 males; 59+/-11 years) with suspected coronary artery disease who had undergone conventional coronary angiography (CA) and MSCT-CA were retrospectively enrolled for the study. Patients underwent a MSCT-CA, with the following protocol: collimation 16x0.75 mm, gantry rotation time 420 ms, feed/rotation 2.8 mm, kV 120, mAs 400-500. The protocol for contrast material administration was 100 ml of Iodixanol 320 mgI/ml at 4 ml/s and the scan delay was defined with a bolus tracking technique. In all patients vascular enhancement was measured in the aortic root, and in the left and right coronary arteries. The average vascular enhancement was used to divide the population in two groups of 50 patients each, one with lower enhancement (Low), and one with higher enhancement (High). In the two groups diagnostic accuracy (per coronary segment) for the detection of significant stenosis (= or >50% lumen reduction) was evaluated in vessels = or >2 mm in diameter using quantitative CA as the reference standard. The differences in diagnostic accuracy were compared with a Chi-square test and a p2 mm lumen diameter), 173 presented significant stenosis. The sensitivity and specificity for the assessment of significant stenosis were 89.4% and 93.3% vs 94.3% and 97.4% in the presence of increasing intravascular enhancement, 92.8% and 96.7% vs 91.1% and 93.9% in the presence of increasing heart rate, and 89.7% and 97.6% vs 93.3% and 92,8% in the presence of an increasing calcium score. CONCLUSIONS: Increasing intravascular enhancement significantly improves diagnostic accuracy in MSCT-CA. A higher heart rate lowers the specificity in the detection of significant obstructing lesions of the coronary artery. An increasing calcium score determines a lower specificity and a higher sensitivity.

33. Spectrum of collateral findings in multislice CT coronary angiography

Author

Massimo Midiri, Giuseppe Runza, F. Alberghina, A. Palumbo, Roberto Malago, Filippo Cademartiri, R. Pozzi Mucelli, Gabriel P. Krestin, Manuel Belgrano, Erica Maffei, Ludovico La Grutta, N. Mollet, Radiology & Nuclear Medicine, Cardiology, CADEMARTIRI F, MALAGO' R, BELGRANO M, ALBERGHINA F, MAFFEI E, LA GRUTTA L, PALUMBO AA, RUNZA G, MOLLET NR, MIDIRI M, KRESTIN GP, MUCELLI RP, Cademartiri, F., Malago, R., Belgrano, MANUEL GIANVALERIO, Alberghina, F., Maffei, E., La Grutta, L., Palumbo, A. A., Runza, G., Mollet, N. R., Midiri, M., Krestin, G. P., and Mucelli, R. P.

Subjects
Male, Radiography, Abdominal, Coronary angiography, medicine.medical_specialty, Time Factors, Multislice CT Coronary Angiography, Collateral findings, Incidental findings, Coronary Disease, Coronary Angiography, Sensitivity and Specificity, Coronary artery disease, Collateral findings, Electrocardiography, Risk Factors, Image Processing, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Neuroradiology, Lung, medicine.diagnostic_test, Multislice CT Coronary Angiography, business.industry, Ultrasound, Interventional radiology, General Medicine, Middle Aged, medicine.disease, Incidental findings, Coronary arteries, medicine.anatomical_structure, Data Interpretation, Statistical, Radiological weapon, Female, Radiography, Thoracic, Radiology, business, Tomography, Spiral Computed, Follow-Up Studies
Abstract

Purpose. The aim of the study was to investigate the prevalence of the noncardiac collateral findings during multislice computed tomography coronary angiography (MSCT-CA). Materials and methods. Six hundred and seventy patients undergoing MSCT-CA with 16-slice and 64-slice CT scanners for suspected atherosclerotic disease of the coronary arteries were retrospectively reviewed. All data sets obtained with a large field of view (FOV) were analysed by two radiologists using standard mediastinal and lung window settings. Collateral findings were divided according to clinical importance into nonsignificant, remarkable and compulsory to be investigated. Results. Eighty-five percent of patients revealed coronary artery disease (CAD). Only 138/670 (20.6%) were without any additional finding. An additional 1,234 findings were recorded: nonsignificant 332 (26.9%), mild 821 (66.53%), compulsory for study 81 (6.56%). A total of 81 patients (12.08%) had significant noncardiac pathology requiring clinical or radiological follow-up. Among these, newly discovered pathologies were revealed in two patients (2.46%). Conclusions. A significant number of noncardiac findings might have been missed in MSCT-CA scans; the appropriate approach should be as a team trained in cardiology and radiology.

34. Norepinephrine weaning guided by the Hypotension Prediction Index in vasoplegic shock after cardiac surgery: protocol for a single-centre, open-label randomised controlled trial - the NORAHPI study.

Author

Beyls C, Lefebvre T, Mollet N, Boussault A, Meynier J, Abou-Arab O, and Mahjoub Y

Subjects
Humans, Prospective Studies, Randomized Controlled Trials as Topic, Postoperative Complications, Machine Learning, Vasoplegia drug therapy, Vasoplegia etiology, Hypotension drug therapy, Hypotension etiology, Norepinephrine therapeutic use, Norepinephrine administration & dosage, Cardiac Surgical Procedures adverse effects, Vasoconstrictor Agents therapeutic use, Vasoconstrictor Agents administration & dosage
Abstract

Introduction: Norepinephrine (NE) is the first-line recommended vasopressor for restoring mean arterial pressure (MAP) in vasoplegic syndrome (vs) following cardiac surgery with cardiopulmonary bypass. However, solely focusing on target MAP values can lead to acute hypotension episodes during NE weaning. The Hypotension Prediction Index (HPI) is a machine learning algorithm embedded in the Acumen IQ device, capable of detecting hypotensive episodes before their clinical manifestation. This study evaluates the clinical benefits of an NE weaning strategy guided by the HPI., Material and Analysis: The Norahpi trial is a prospective, open-label, single-centre study that randomises 142 patients. Inclusion criteria encompass adult patients scheduled for on-pump cardiac surgery with postsurgical NE administration for vs patient randomisation occurs once they achieve haemodynamic stability (MAP>65 mm Hg) for at least 4 hours on NE. Patients will be allocated to the intervention group (n=71) or the control group (n=71). In the intervention group, the NE weaning protocol is based on MAP>65 mmHg and HPI<80 and solely on MAP>65 mm Hg in the control group. Successful NE weaning is defined as achieving NE weaning within 72 hours of inclusion. An intention-to-treat analysis will be performed. The primary endpoint will compare the duration of NE administration between the two groups. The secondary endpoints will include the prevalence, frequency and time of arterial hypotensive events monitored by the Acumen IQ device. Additionally, we will assess cumulative diuresis, the total dose of NE, and the number of protocol weaning failures. We also aim to evaluate the occurrence of postoperative complications, the length of stay and all-cause mortality at 30 days., Ethics and Dissemination: Ethical approval has been secured from the Institutional Review Board (IRB) at the University Hospital of Amiens (IRB-ID:2023-A01058-37). The findings will be shared through peer-reviewed publications and presentations at national and international conferences., Trial Registration Number: NCT05922982., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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35. Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve.

Author

Rossi A, Uitterdijk A, Dijkshoorn M, Klotz E, Dharampal A, van Straten M, van der Giessen WJ, Mollet N, van Geuns RJ, Krestin GP, Duncker DJ, de Feyter PJ, and Merkus D

Subjects
Animals, Blood Flow Velocity, Coronary Circulation physiology, Disease Models, Animal, Exercise Test methods, Imaging, Three-Dimensional, Random Allocation, Sensitivity and Specificity, Severity of Illness Index, Swine, Tomography, X-Ray Computed methods, Adenosine, Coronary Angiography methods, Coronary Stenosis diagnosis, Fractional Flow Reserve, Myocardial physiology, Myocardial Perfusion Imaging methods
Abstract

Aims: Only few preliminary experimental studies demonstrated the feasibility of adenosine stress CT myocardial perfusion imaging to calculate the absolute myocardial blood flow (MBF), thereby providing information whether a coronary stenosis is flow limiting. Therefore, the aim of our study was to determine whether adenosine stress myocardial perfusion imaging by Dual Source CT (DSCT) enables non-invasive quantification of regional MBF in an animal model with various degrees of coronary flow reduction., Methods and Results: In seven pigs, a coronary flow probe and an adjustable hydraulic occluder were placed around the left anterior descending coronary artery to monitor the distal coronary artery blood flow (CBF) while several degrees of coronary flow reduction were induced. CT perfusion (CT-MBF) was acquired during adenosine stress with no CBF reduction, an intermediate (15-39%) and a severe (40-95%) CBF reduction. Reference standards were CBF and fractional flow reserve measurements (FFR). FFR was simultaneously derived from distal coronary artery pressure and aortic pressure measurements. CT-MBF decreased progressively with increasing CBF reduction severity from 2.68 (2.31-2.81)mL/g/min (normal CBF) to 1.96 (1.83-2.33) mL/g/min (intermediate CBF-reduction) and to 1.55 (1.14-2.06)mL/g/min (severe CBF-reduction) (both P < 0.001). We observed very good correlations between CT-MBF and CBF (r = 0.85, P < 0.001) and CT-MBF and FFR (r = 0.85, P < 0.001)., Conclusion: Adenosine stress DSCT myocardial perfusion imaging allows quantification of regional MBF under various degrees of CBF reduction.

Published
2013
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36. Geometry and degree of apposition of the CoreValve ReValving system with multislice computed tomography after implantation in patients with aortic stenosis.

Author

Schultz CJ, Weustink A, Piazza N, Otten A, Mollet N, Krestin G, van Geuns RJ, de Feyter P, Serruys PW, and de Jaegere P

Subjects
Aged, Aged, 80 and over, Aortic Valve surgery, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis physiopathology, Blood Flow Velocity, Cardiac Catheterization, Echocardiography, Female, Humans, Male, Prosthesis Design, Aortic Valve diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Tomography, X-Ray Computed
Abstract

Objectives: Using multislice computed tomography (MSCT), we sought to evaluate the geometry and apposition of the CoreValve ReValving System (CRS, Medtronic, Luxembourgh, Luxembourgh) in patients with aortic stenosis., Background: There are no data on the durability of percutaneous aortic valve replacement. Geometric factors may affect durability., Methods: Thirty patients had MSCT at a median 1.5 months (interquartile range [IQR] 0 to 7 months) after percutaneous aortic valve replacement. Axial dimensions and apposition of the CRS were evaluated at 4 levels: 1) the ventricular end; 2) the nadir; 3) central coaptation of the CRS leaflets; and 4) commissures. Orthogonal smallest and largest diameters and cross-sectional surface area were measured at each level., Results: The CRS (26-mm: n = 14, 29-mm: n = 16) was implanted at 8.5 mm (IQR 5.2 to 11.0 mm) below the noncoronary sinus. None of the CRS frames reached nominal dimensions. The difference between measured and nominal cross-sectional surface area at the ventricular end was 1.6 cm(2) (IQR 0.9 to 2.6 cm(2)) and 0.5 cm(2) (IQR 0.2 to 0.7 cm(2)) at central coaptation. At the level of central coaptation the CRS was undersized relative to the native annulus by 24% (IQR 15% to 29%). The difference between the orthogonal smallest and largest diameters (degree of deformation) at the ventricular end was 4.4 mm (IQR 3.3 to 6.4 mm) and it decreased progressively toward the outflow. Incomplete apposition of the CRS frame was present in 62% of patients at the ventricular end and was ubiquitous at the central coaptation and higher., Conclusions: Dual-source MSCT demonstrated incomplete and nonuniform expansion of the CRS frame, but the functionally important mid-segment was well expanded and almost symmetrical. Undersizing and incomplete apposition were seen in the majority of patients.

Published
2009
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37. Integration of multislice computed tomography with magnetic navigation facilitates percutaneous coronary interventions without additional contrast agents.

Author

Ramcharitar S, Pugliese F, Schultz C, Ligthart J, de Feyter P, Li H, Mollet N, van de Ent M, Serruys PW, and van Geuns RJ

Subjects
Aged, Coronary Artery Disease diagnosis, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Feasibility Studies, Female, Humans, Male, Middle Aged, Time Factors, Ultrasonography, Interventional, Angioplasty, Balloon, Coronary methods, Contrast Media, Coronary Angiography, Coronary Artery Disease therapy, Magnetics, Tomography, X-Ray Computed methods
Abstract

Objectives: We hypothesized that percutaneous coronary intervention (PCI) without additional contrast agents can be performed by directly integrating multislice computed tomography coronary angiography (CTCA) within the magnetic navigation system (MNS)., Background: Increasingly, CTCA is being used in the diagnostic work-up of patients with coronary disease. Its inherent 3-dimensional information should be exploited, as it potentially offers advantages over 2-dimensional radiography in guiding invasive diagnostic and therapeutic interventions., Methods: CTCA-derived centerlines from 15 patients were coregistered and overlaid on real-time fluoroscopic images employing the MNS. Vessels were manually wired with a magnetically enabled guidewire assisted by variable local magnetic fields. Fractional flow reserve (FFR) determined the lesion severity, and the dimensions were quantified by intravascular ultrasound (IVUS). Locations of the IVUS catheter probe along the lesion were incorporated in software to facilitate stenting without contrast agents., Results: The average crossing and fluoroscopic times were 105.3 +/- 35.5 s and 83.4 +/- 38.6 s, respectively, with no contrast agents used in 11 of 15 patients (73.3%). Contrast agents were used in only 1 of 10 patients (10%) in whom an IVUS was performed. In 4 patients, apart from a "blinded" safety check angiogram, the entire PCI (lesion crossing, stent sizing, positioning, and deployment) was performed without additional contrast agents following the coregistration of the IVUS probe position in the MNS., Conclusions: The integration of pre-procedural CTCA within the MNS can facilitate PCI without additional contrast agents.

Published
2009
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40. Images in cardiovascular medicine. Neointimal hyperplasia in carotid stent detected with multislice computed tomography.

Author

Cademartiri F, Mollet N, Nieman K, Krestin GP, and de Feyter PJ

Subjects
Aged, Carotid Artery, Common diagnostic imaging, Carotid Artery, Internal diagnostic imaging, Carotid Stenosis surgery, Graft Occlusion, Vascular etiology, Humans, Hyperplasia etiology, Internet, Male, Video Recording, Graft Occlusion, Vascular diagnostic imaging, Hyperplasia diagnostic imaging, Stents adverse effects, Tomography, X-Ray Computed methods, Tunica Intima diagnostic imaging
Published
2003
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41. Images in cardiovascular medicine. Late-late occlusion after intracoronary brachytherapy.

Author

Sianos G, Mollet N, Hofma S, de Feyter PJ, and Serruys PW

Subjects
Angina Pectoris etiology, Angioplasty, Balloon, Coronary adverse effects, Coronary Artery Bypass, Coronary Artery Disease surgery, Echocardiography, Three-Dimensional, Electrocardiography, Humans, Internet, Male, Middle Aged, Myocardial Infarction complications, Myocardial Infarction therapy, Recurrence, Thrombolytic Therapy, Time, Video Recording, Brachytherapy adverse effects, Coronary Angiography, Coronary Artery Disease diagnosis, Tomography, X-Ray Computed methods, Ultrasonography, Interventional
Published
2003
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42. Imaging of coronary atherosclerosis and identification of the vulnerable plaque.

Author

de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AF, Krams R, Schaar JA, Wielopolski P, Pattynama PM, Arampatzis A, van der Lugt A, Regar E, Ligthart J, and Smits P

Abstract

Identification of the vulnerable plaque responsible for the occurrence of acute coronary syndromes and acute coronary death is a prerequisite for the stabilisation of this vulnerable plaque. Comprehensive coronary atherosclerosis imaging in clinical practice should involve visualisation of the entire coronary artery tree and characterisation of the plaque, including the three-dimensional morphology of the plaque, encroachment of the plaque on the vessel lumen, the major tissue components of the plaque, remodelling of the vessel and presence of inflammation. Obviously, no single diagnostic modality is available that provides such comprehensive imaging and unfortunately no diagnostic tool is available that unequivocally identifies the vulnerable plaque. The objective of this article is to discuss experience with currently available diagnostic modalities for coronary atherosclerosis imaging. In addition, a number of evolving techniques will be briefly discussed.

Published
2003

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