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Invadopodia are finger-like protrusions that are commonly spotted at the membrane of the invasive cancer cell. These structures are a major cause of death among cancer patients through metastasis process. Signal transduction stimulated upon contact between ligand and membrane receptors is identified as one of key factors in invadopodia formation. In this study, a time-dependent mathematical model of signal and ligand is investigated numerically. The moving boundary of plasma membrane is taken as a zero-level set function and is moved by the velocity that accounted as the difference of gradient between intra-cellular signal and extra-cellular ligand. The model is solved using a combination of ghost with linear extrapolation and finite difference methods. The results showed that the stimulation of signal from membrane associated ligand consequently moved the plasma membrane outward as time increases. The highest densities of signal and ligand are recorded on the membrane and slowly diffused into intra-cellular and extra-cellular regions, respectively.

Low-cost green ceramic hollow fiber membranes (CHFM) were successfully designed and fabricated from the industrial waste ash, palm oil fuel ash (POFA) via phase inversion-based extrusion/sintering techniques for water filtration application. The extrusion process parameters such as suspension viscosity, air gap distance, and bore fluid flow rate were systematically explored to produce the membrane with desired morphology. A high suspension viscosity would result in a small macro-voids structure. Moreover, a high air gap distance would induce fiber with long macro-voids structure, while a low bore fluid flow rate would lead to the formation of distorted lumen structure. The effect of sintering temperature toward CHFM was also studied and characterized. An increase in the sintering temperature improved the membrane bending strength, but also afflicted the flux performance due to lower porosity and higher tortuosity. The developed membranes achieved excellent bending strengths of >75 MPa at lower sintering temperatures than the alternative ceramic counterparts, due to the formation of the eutectic liquid during sintering. The relatively low sintering temperature of POFA-derived CHFMs could reduce the energy consumption and sintering duration, which could be more economically attractive than their ceramic counterparts, thus benefiting industrial users.

The fluid flow with chemical reaction is one of well-known research areas in the field of computational fluid dynamic. It is potentially useful in the modelling of flow on a nuclear reactor. Motivated by the implementation of the flow in the industrial application, the aim of this study is to explore the time-dependent squeeze flow of magnetohydrodynamic Jeffrey fluid over permeable medium in the influences of Soret and Dufour, heat source/sink and chemical reaction. The presence of joule heating, joule dissipation and radiative heat transfer are analyzed. The flow is induced due to compress of two surfaces. Conversion of partial differential equations (PDEs) into ordinary differential equations (ODEs) is accomplished by imposing similarity variables. Then, the governing equations are resolved using Keller-box approach. The present outcomes are compared with previously outcomes in the literature to validate the precision of present outcomes. Both outcomes are shown in close agreement. The tabular and graphical results demonstrate that wall shear stress and velocity profile accelerate with the surfaces moving towards one another. Moreover, the concentration, temperature and velocity profiles decreasing for the increment of Hartmann numbers and Jeffrey fluid parameters. The impacts of heat generation/absorption, joule dissipation and Dufour numbers enhance the heat transfer rate and temperature profile. In contrast, the temperature profile drops and the heat transfer rate boosts when thermal radiation increases. The concentration profile decelerates, and the mass transfer rate elevates with raise in Soret number. Also, the mass transfer rate rises for destructive chemical reaction and contrary result is noted for convective chemical reaction.

The heat and mass transfer on time dependent hydrodynamic squeeze flow of Jeffrey nanofluid across two plates over permeable medium in the slip condition with heat generation/absorption, thermal radiation and chemical reaction are investigated. The impacts of Brownian motion and thermophoresis is examined in the Buongiorno's nanofluid model. Conversion of the governing partial differential equations to the ordinary differential equations is conducted via similarity transformation. The dimensionless equations are solved by imposing numerical method of Keller-box. The outputs are compared with previous reported works in the journals for the validation of the present outputs and found in proper agreement. The behavior of velocity, temperature, and nanoparticles concentration profiles by varying the pertinent parameters are examined. Findings portray that the acceleration of the velocity profile and the wall shear stress is due to the squeezing of plates. Furthermore, the velocity, temperature and concentration profile decline with boost in Hartmann number and ratio of relaxation to retardation times. It is discovered that the rate of heat transfer and temperature profile increase when viscous dissipation, thermophoresis and heat source/sink rises. In contrast, the increment of thermal radiation reduces the temperature and enhances the heat transfer rate. Besides, the mass transfer rate decelerates for increasing Brownian motion in nanofluid, while it elevates when chemical reaction and thermophoresis increases.

The heat and mass transfer characteristics on hydromagnetic squeeze flow of Jeffrey nanofluid between two plates over a permeable medium by slip condition with the influences of viscous dissipation and chemical reaction is examined. Buongiorno’s nanofluid model, which includes Brownian motion and thermophoresis impacts, is implemented in this research. The governing nonlinear partial differential equations are transformed to the nonlinear ordinary differential equations via asimilarity transformation. The transformed equations are solved by employing numerical techniques of Keller-box. A comparison of the skin friction coefficient, Nusselt and Sherwood numbers with reported outputs in the journals are carried out to validate the present outputs. An excellent agreement is found. The results show that the squeezing of plates accelerates the velocity and wall shear stress. Furthermore, the velocity, temperature and concentration profile decrease when the Hartmann number and ratio of relaxation and retardation times increases. The raise in thermophoresis and viscous dissipation elevate the temperature profile and the heat transfer rate. Furthermore, the mass transfer rate declines due to the strong Brownian motion in the nanofluid, whereas it increases with the addition of chemical reaction and thermophoresis.

Although there are several studies conducted by linguistics researchers on the differences between the linguistic styles of female and male writers, there are not many studies conducted on the use of boosters in academic writing. Boosters are used to convince and emphasize statements made. This study analyzes the regularity of boosters used in the Introduction section of Ten Research Articles (RAs). The influence of gender differences in the use of specific boosters will also be looked at. A document analysis method was chosen as the 10 RAs were analyzed as the corpus in this study. The findings showed that male writers used more boosters than female writers. Even though the number of words for the female writers was more than the male writers, it did not affect the number of boosters used in the Introduction section of those articles. In conclusion, it can be deduced from the analysis that both the female and male writers used boosters to highlight their claims or their beliefs regardless of their gender, while the use of boosters was more evident among the male RAs as the male writers seemed to be more direct in illustrating and mentioning their claims.

The ability of rural entrepreneurs to cope with the COVID-19 pandemic greatly depends on their knowledge of Information and Communication Technology (ICT) to support online business. In this study, online surveys were conducted to assess the readiness and acceptance of rural entrepreneurs in adopting to the pandemic using the available technologies. Data collected were analyzed by descriptive and inferential statistics using ANOVA. Online training modules were designed based on their specific needs. Although participants indicated that their frequency and skills of using the electronic devices or applications had generally increased or improved after the training, the increment was not statistically significant ([alpha]=0.05). This indicated that while the participants, to some extent, benefited from the online training provided, there has not been a significant impact on them.

Vocabulary is often neglected despite being one of the most crucial aspects of language acquisition. Due to the lack of emphasis on vocabulary learning, ESL students have issues in learning the English language effectively, which resulted in low-level language proficiency. Hence, this paper attempts to address this problem by introducing Visual Vocabulary to learn the target words. The main research question: How effective is the use of the Visual Vocabulary to learn vocabulary for Form Two learners? To investigate the effectiveness of the use of the Visual Vocabulary, 60 students of Form Two from sub-urban schools in Ipoh and Teluk Intan, Perak, were selected. These students were instructed to learn a total of 45 target words and Visual Vocabulary was applied to assist them to learn and simultaneously understand the meaning of the target words. The independent sample t-test, paired sample t-test, and descriptive statistics were used to analyze the scores of the pre and post-tests. The score comparison and total improvement score in percentage were also presented. The paired sample t-test results are (t=-17.85, df=29, p<0.05) for the experimental group and (t=-4.85, df=29, p<0.05) for the control group. Based on the stated results, both experimental and control groups improved significantly (p=.000*) in the post-test with a mean difference of 15.62. The results of this study confirm the effectiveness of Visual Vocabulary in learning and understanding the target words. This approach is proven to increase the success rate of vocabulary learning among ESL learners.

Author(s): Jie Cong Yeoh [1]; Nazhan Afeef Bin Mohd Ariff [2]; Larry Ellee Nyanti (corresponding author) [3] Dear Editor, Emergency cricothyroidotomy is a guideline-advocated, potentially life-saving procedure.[sup.[1]] While its true [...]

Pneumonia, asthma, sudden infant death syndrome (SIDS), and the most recent epidemic, COVID-19, are the most common lung diseases associated with respiratory difficulties. However, existing health monitoring systems use large and in-contact devices, which causes an uncomfortable experience. The difficulty in acquiring breathing signals for non-stationary individuals limits the use of ultra-wideband radar for breathing monitoring. This is due to ineffective signal clutter removal and body movement removal algorithms for collecting accurate breathing signals. This paper proposes a breathing signal analysis for non-contact physiological monitoring to improve quality of life. The radar-based sensors are used for collecting the breathing signal for each subject. The processed signal has been analyzed using continuous wavelet transform (CWT) and wavelet coherence with the Monte Carlo method. The finding shows that there is a significant difference between the three types of breathing patterns; normal, high, and slow. The findings may provide a comprehensive framework for processing and interpreting breathing signals, resulting in breakthroughs in respiratory healthcare, illness management, and overall well-being. [ABSTRACT FROM AUTHOR]

In the process of learning, many elements fall into place wholly in order to enhance effectiveness. These elements include not only environmental factors but also learners' mentality which involves their feelings, needs and interests. Humanism approach is one which caters these elements required by learners' learning process through emphasis on student-centeredness in class. The paradigm of this approach is mainly on what learners desire to learn, instead of teaching them what is perceived to be essentially acquired. For years, there have been controversial debates concerning the effectiveness of the humanism approach in teaching. With the aim of scrutinizing the relevance and applicability of this approach in the Malaysian teaching context, a humanistic lesson was conducted and recorded in Universiti Tenaga Nasional (UNITEN). The lesson was then analysed to obtain some results.

Humour in English Language Teaching (ELT) is known to be beneficial for both the educators and students. However, the literature addressing the types of humour used by Malaysian lecturers in higher education on this matter are yet to be explored. To address these issues, the study focusses to explore on the types of humour used in ELT by Malaysian lecturers in relation to the four types of humour: verbal, visual, auditory and figural humour. The research design is a qualitative study which implements two instruments; classroom observation and semi-structured interviews. Thematic analysis will be used to analyse the data. The results from the study show that there are three types of humour commonly used: verbal humour, visual humour and auditory humour. The data analysis indicates that there are four factors which influence the types of humour used in the classroom: humour used for content delivery, humour to build rapport, humour to attract attention and humour to instil discipline. [ABSTRACT FROM AUTHOR]

The potential for Massive Open Online Courses (MOOCs) in clinical dentistry remains vague and inadequately explored. Objectives: The study aims to obtain insight into the development of MOOCs in Fixed Partial Dental Prostheses (FPDPs) and to assess students' learning preferences, module quality, and interface usability. Methods: The MOOCs was created by seven academicians with prosthodontic backgrounds. After completing the MOOCs and three complementary online discussion sessions, the students (n = 89) were invited to participate in an online survey. SPSS version 23 was used to calculate the frequency, percentage, mean, and standard deviation of categorical data (SD). Results: A total of 84.1% of students completed the survey. Six modules with five different FPDPs topics and a single implant topic were created for this MOOCs, which consists teaching and practical modules. 94.6% of respondents agreed that MOOCs can be used to supplement traditional T&L, with 64.9% preferring MOOCs to traditional classrooms. The majority of the items received a high mean score above 4.00, indicating that the majority of respondents were satisfied with the developed MOOC's course content, usability, and interface. Conclusion: The majority of respondents agreed that the overall course content is well-organized and expressed positive feedback on integrating MOOCs into traditional classrooms. [ABSTRACT FROM AUTHOR]