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In order to improve the dynamic performance of the sensorless permanent magnet synchronous motor drive system, the modified pulsating high frequency voltage injection method is proposed. Firstly, the second order generalized integrator can be used to extract the high frequency voltage signal instead of band-pass filters. The specific frequency harmonic elimination unit is applied to obtain the rotor position error signal to avoid using the low-pass filter. Therefore, the system dynamic performance can be improved. In addition, the system parameter is easier to adjust than traditional methods with band-pass filters and low-pass filters. Finally, the simulation model and experimental platform are built to verify the effectiveness of the proposed method. The simulation and experimental results present that the dynamic performance of motor drive system can be improved.

In order to reduce the axial length and increase the critical speed of the small magnetic suspension drive system, a new slice hybrid magnetic bearing (SHMB) with two radial air-gaps is proposed. The structure and suspension mechanism of the SHMB is introduced, and then the mathematical models of the radial suspension force are deduced using the equivalent magnetic circuit method. The suspension mechanism is proved. The radial and axial suspension forces are then calculated by the finite element method. The experimental prototype SHMB is finally designed and constructed. The stable suspension of the rotor is realized, and the suspension forces are measured. The results of the finite element calculation and experimental measurement verify the correctness of the mathematical models.

To reduce the volume of the five degrees of freedom (DOF) magnetic suspension system and increase the critical speed, a slice hybrid magnetic bearing (SHMB) is proposed. First, the mathematical models of the radial suspension are deduced using the equivalent magnetic circuit method based on the suspension mechanism analysis. Then, the parameters of the five-DOF SHMB are designed. The magnetic circuits are analyzed, and the relationships between the radial suspension force and the suspension currents are calculated. Furthermore, the relationships between the axial force and the axial offset are also calculated. Finally, The experimental prototype five-DOF SHMB is designed and the suspension forces are tested. The research results have shown that the rotor can be levitated stably in five DOF.

The traditional bearingless permanent magnet synchronous motor has complex decoupling control problems. To overcome the drawbacks above, a novel hybrid permanent magnet type bearingless motor (HPMTBM) is proposed in this paper, which has integrated the merits of hybrid excitation permanent magnet motor and magnetic bearings. The main advantages of this HPMTBM are the simple control mechanism and the low power consumption. First, the principle and theoretical background of this motor are introduced. Then, the mathematical models of radial suspension force and torque are established using Maxwell stress tensor method, and air-gap magnetic fields, radial suspension forces are calculated by finite-element analysis. Finally, the prototype motor is designed and constructed. The radial suspension forces and rotor radial displacements are tested. The simulation and experimental results show the feasibility of the proposed HPMTBM.

A correlation between expression of the glucose-regulated protein of 78 kDa (GRP78) in malignant melanoma tumors and poor patient survival is well established. In this study, in addition to demonstrating the expression of GRP78 in tumor tissue, we investigated the immune response against GRP78 in a group of patients with different progression stages of malignant melanoma. Furthermore, we analyzed the glycosylation status of GRP78 immunoglobulin (Ig) G autoantibodies at these stages and evaluated their capacities to affect the protein B-dependent protein kinase signaling pathway and unfolded protein response signaling mechanisms, all known to promote malignant melanoma cell proliferation and survival. We found that progression of disease correlates not only with enhanced expression of GRP78 in the tumor but also with an increase in GRP78 autoantibody serum titers in these patients. We also found that the glycosylation status of anti-GRP78 IgG changes as the disease progresses. The anti-GRP78 IgG is abnormally glycosylated in the Fc region and asymmetrically glycosylated in the Fab region. We demonstrate that hyperglycosylated anti-GRP78 IgGs stimulate cell proliferation through protein B-dependent protein kinase signaling pathways. They also mimic the effects of α2-macroglobulin on the upregulation of GRP78 and X-box binding protein 1, activating transcription factor 6 α, and serine/threonine-protein kinase/endoribonuclease precursor α as endoplasmic reticulum stress biomarkers and show no effect on expression or activation of caspases 3, 9, or 12. In conclusion, the anti-GRP78 IgG autoantibodies downregulate apoptosis and activate unfolded protein response mechanisms, which are essential to promote melanoma cell growth and survival.