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5. 腹腔鏡手術時代における早期胃癌に対する幽門輪温存胃切除術の再評価 : 適応と初期成績に関する検討

Author

Wajima, Naoki, Morohashi, Hajime, Watanabe, Nobukazu, Nakai, Makoto, Miyamoto, Keiichi, Kawasaki, Hitoshi, Yonaiyama, Shinnosuke, Ogasawara, Hiroshi, Yoshikawa, Toru, Muroya, Takahiro, Yakoshi, Yuta, Ishido, Keinosuke, Sakamoto, Yoshiyuki, Koyama, Motoi, Murata, Akihiko, Ohishi, Susumu, Tateoka, Hiroshi, and Hakamada, Kenichi

Subjects
早期胃癌, function-preserving surger, 縮小手術, 腹腔鏡補助下幽門温存胃切除, limited surgery, Laparoscopy-assisted pylorus-preserving gastrectomy, 機能温存手術, early gastric cancer, 低侵襲手術, 外科系臨床医学, minimally-invasive surgery
Abstract

INTRODUCTION: Pylorus-preserving gastrectomy （PPG）, which had been developed in 1960s, has been reappraised for years and now accepted as a type of function-preserving compared with those of laparoscopy- ssisted distal gastrectomy （LADG）, which does not preserve the pylorus and involves resection of the suprapyloric lymph nodes. METHODS: Ninety six patients diagnosed as having gastric cancer of cT1N0 underwent either LADG （n=66） or LAPPG （n=30）. The patient demographics and the early surgical outcomes were evaluated retrospectively. The quality of lymph node dissection in LAPPG was also assessed pathologically. RESULTS: Among 96 patients preoperatively diagnosed as cT1, pT1 was 88 cases and pT2 in 8, 91.7 % of diagnostic accuracy. There were no differences in patient demographics, operative time, blood loss, the number of dissected lymph nodes, postoperative morbidity and length of hospitalization. Pathologically, the number of dissected lymph nodes at No. 3, 4, 6 were equal between the two groups. Among our LADG cases, 35（ 53%） were lesions confined to the mucosa with a distance between the pylorus and the anal margin of the tumor, 弘前医学. 62, 2011, p.180-185

Published
2011

8. Vimentin expression of esophageal squamous cell carcinoma and its aggressive potential for lymph node metastasis

Author

Jin, Hiroyuki, primary, Morohashi, Satoko, additional, Sato, Fuyuki, additional, Kudo, Yasuyuki, additional, Akasaka, Harue, additional, Tsutsumi, Shinji, additional, Ogasawara, Hiroshi, additional, Miyamoto, Keiichi, additional, Wajima, Naoki, additional, Kawasaki, Hitoshi, additional, Hakamada, Kenichi, additional, and Kijima, Hiroshi, additional

Published
2010
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11. Method of Cell Transplantation Promoting the Organization of Intraarterial Thrombus

Author

Hirano, Koji, primary, Shimono, Takatsugu, additional, Imanaka-Yoshida, Kyoko, additional, Miyamoto, Keiichi, additional, Fujinaga, Kazuya, additional, Kajimoto, Masaki, additional, Miyake, Yoichiro, additional, Nishikawa, Masakatsu, additional, Yoshida, Toshimichi, additional, Uchida, Atsumasa, additional, Shimpo, Hideto, additional, Yada, Isao, additional, and Hirata, Hitoshi, additional

Published
2005
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15. Development of a new method for endovascular aortic repair: combination therapy of cell transplantation and stent grafts with a drug delivery system.

Author

Kajimoto M, Shimono T, Hirano K, Miyake Y, Sawada Y, Kato N, Hirata H, Imanaka-Yoshida K, Nishikawa M, Yoshida T, Shimpo H, Horiuchi T, and Miyamoto K

Subjects
Animals, Aortic Aneurysm, Thoracic drug therapy, Aortic Aneurysm, Thoracic pathology, Blood Coagulation, Catheterization, Cells, Cultured transplantation, Collagen administration & dosage, Combined Modality Therapy, Dogs, Drug Implants, Elastin, Equipment Design, Equipment Failure, Fibroblast Growth Factor 2 administration & dosage, Fibroblast Growth Factor 2 genetics, Fibrosis, Gels, Humans, Muscle, Skeletal cytology, Polytetrafluoroethylene, Recombinant Proteins administration & dosage, Recombinant Proteins therapeutic use, Stainless Steel, Transplantation, Autologous, Aortic Aneurysm, Thoracic surgery, Fibroblast Growth Factor 2 therapeutic use, Fibroblasts transplantation, Implants, Experimental adverse effects, Myoblasts transplantation, Stents adverse effects
Abstract

Background: Endovascular aortic repair by stent grafts (S/Gs) has been developed as a less invasive treatment for aortic aneurysms. However, some aneurysmal cavities can remain without organization, causing re-expansion. We demonstrated previously that transplantation of a cell combination (myoblasts and fibroblasts) promoted thrombus organization in a rat model. We also developed basic fibroblast growth factor (bFGF) slow-delivery S/Gs coated with elastin and impregnated with bFGF. Here, we evaluated the effects of cell transplantation combined with bFGF slow release on canine thoracic aortic aneurysmal sacs after S/Gs repair., Methods and Results: Thoracic aortic aneurysms were surgically created with jugular vein patches in 15 beagles. Myoblasts and fibroblasts of autologous skeletal muscle were isolated and cultured for cell transplantation. The S/Gs had 6 holes and produced endoleaks in the excluded cavities. Collagen gel (gel group, n=5) or a mixture of skeletal myoblasts and fibroblasts with collagen gel (cell group, n=5) were injected into the aneurysmal sacs excluded by the S/Gs. We also studied the effects of combined therapy of bFGF slow-release S/Gs and cell transplantation (hybrid group, n=5). After 14 days, histological analyses revealed that the excluded aneurysmal cavities of the gel group were filled with fresh thrombus, whereas the excluded cavities in the cell-transplanted groups were occupied by organized tissue. The percentages of the organized areas relative to the excluded cavities, evaluated by Masson's trichrome staining, were 18.1+/-4.0%, 52.6+/-4.0%, and 77.1+/-6.9% in the gel, cell, and hybrid groups, respectively. Collagen fibers had already appeared, and increased numbers of alpha-smooth muscle actin-positive cells were observed in the hybrid group., Conclusions: Cell transplantation accelerated thrombus organization. Moreover, slow release of bFGF enhanced the effects of cell transplantation. Cell transplantation into unorganized spaces may improve the outcomes of endovascular treatments of aortic aneurysms.

Published
2006
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