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4. Long-term outcomes of patients with primary intestinal follicular lymphoma managed with watch-and-wait strategy

Author

Iwamuro, Masaya, Tanaka, Takehiro, Ennishi, Daisuke, Matsueda, Kazuhiro, Yoshioka, Masao, Miyahara, Koji, Sakaguchi, Chihiro, Nishimura, Mamoru, Nagahara, Teruya, Mannami, Tomohiko, Takenaka, Ryuta, Oka, Shohei, Inoue, Masafumi, Takimoto, Hidetaka, Inaba, Tomoki, Kobayashi, Sayo, Toyokawa, Tatsuya, Tsugeno, Hirofumi, Suzuki, Seiyuu, Sawada, Sachiko, Tanaka, Shouichi, Tsuzuki, Takao, and Okada, Hiroyuki

Published
2023
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5. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Kanzaki, Hiromitsu, Inoue, Shuntaro, Miyake, Muneaki, Ohmori, Masayasu, Takeuchi, Yoji, Tani, Yasuhiro, Harada, Nobuyuki, Agatsuma, Nobukazu, Okada, Keijirou, Ikenouchi, Maiko, Nakatani, Yasuki, Uenoyama, Yoshito, Yamashita, Yukitaka, Ishikawa, Shigenao, Inaba, Tomoki, Miyahara, Koji, Moritou, Yuki, Nakagawa, Masahiro, Kitae, Hiroaki, Ishida, Tsugitaka, Naito, Yuji, Nishio, Akiyoshi, Shimatani, Masaaki, Kato, Ryo, Taki, Shinya, Mandai, Koichiro, Sanada, Kasumi, Nakase, Kojiro, Nebiki, Hiroko, Saito, Shunsuke, Wakatsuki, Toshiyuki, Nishimura, Naoyuki, Yamasaki, Yasushi, Uedo, Noriya, Akamatsu, Takuji, Kagawa, Tomo, Higashi, Reiji, Dohi, Osamu, Furukawa, Masanori, Takahashi, Yu, Inoue, Takuya, Tanaka, Shouichi, Takenaka, Ryuta, Iguchi, Mikitaka, Kawamura, Takuji, Tsuzuki, Takao, Yamasaki, Tomoaki, Yamashina, Takeshi, Nasu, Junichiro, Mannami, Tomohiko, Yamauchi, Atsushi, Matsueda, Kazuhiro, Aizawa, Shigeyuki, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Published
2022
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7. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

9. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Yamasaki, Yasushi, primary, Uedo, Noriya, additional, Akamatsu, Takuji, additional, Kagawa, Tomo, additional, Higashi, Reiji, additional, Dohi, Osamu, additional, Furukawa, Masanori, additional, Takahashi, Yu, additional, Inoue, Takuya, additional, Tanaka, Shouichi, additional, Takenaka, Ryuta, additional, Iguchi, Mikitaka, additional, Kawamura, Takuji, additional, Tsuzuki, Takao, additional, Yamasaki, Tomoaki, additional, Yamashina, Takeshi, additional, Nasu, Junichiro, additional, Mannami, Tomohiko, additional, Yamauchi, Atsushi, additional, Matsueda, Kazuhiro, additional, Aizawa, Shigeyuki, additional, Mitsuhashi, Toshiharu, additional, Okada, Hiroyuki, additional, Kanzaki, Hiromitsu, additional, Inoue, Shuntaro, additional, Miyake, Muneaki, additional, Ohmori, Masayasu, additional, Takeuchi, Yoji, additional, Tani, Yasuhiro, additional, Harada, Nobuyuki, additional, Agatsuma, Nobukazu, additional, Okada, Keijirou, additional, Ikenouchi, Maiko, additional, Nakatani, Yasuki, additional, Uenoyama, Yoshito, additional, Yamashita, Yukitaka, additional, Ishikawa, Shigenao, additional, Inaba, Tomoki, additional, Miyahara, Koji, additional, Moritou, Yuki, additional, Nakagawa, Masahiro, additional, Kitae, Hiroaki, additional, Ishida, Tsugitaka, additional, Naito, Yuji, additional, Nishio, Akiyoshi, additional, Shimatani, Masaaki, additional, Kato, Ryo, additional, Taki, Shinya, additional, Mandai, Koichiro, additional, Sanada, Kasumi, additional, Nakase, Kojiro, additional, Nebiki, Hiroko, additional, Saito, Shunsuke, additional, Wakatsuki, Toshiyuki, additional, and Nishimura, Naoyuki, additional

Published
2022
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11. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, Okada, Hiroyuki, Hamada, Kenta, Kanzaki, Hiromitsu, Inoue, Masafumi, Ishiyama , Shuhei, Yamauchi, Kenji, Miyahara, Koji, Toyokawa, Tatsuya, Tsuzuki, Takao, Miyaike, Jiro, Matsubara, Minoru, Takahashi, Sakuma, Nishimura, Mamoru, Takenaka, Ryuta, Yunoki, Naoko, Hori, Shinichiro, Kobayashi, Sayo, Yamasaki, Yasushi, Kawahara, Yoshiro, Ishikawa, Hideki, and Okada, Hiroyuki

Abstract

Objective Gastric endoscopic submucosal dissection (ESD) under heparin replacement (HR) of warfarin reportedly has a high risk of delayed bleeding (24-57%). It is possible that the delayed bleeding risk may have changed over the years. We evaluated the current risk of delayed bleeding after gastric ESD under HR of anticoagulant agents. Methods We retrospectively reviewed the delayed bleeding rate and analyzed the risk factors for delayed bleeding. Patients Consecutive patients who underwent gastric ESD under HR of anticoagulant agents from July 2015 to June 2017. Results A total of 32 patients with a solitary early gastric cancer and taking anticoagulant agents were analyzed, including 24 patients on warfarin (the warfarin group) and 8 patients on direct oral anticoagulants (the DOAC group). Three (9.4%) patients experienced delayed bleeding: three (12.5%) patients in the warfarin group and no patients in the DOAC group. Continued aspirin treatment was identified to be a risk factor of delayed bleeding (p=0.01). Conclusion Careful management may be required for patients undergoing gastric ESD under continued aspirin treatment in addition to HR of anticoagulant agents; although the delayed bleeding risk after gastric ESD under HR of anticoagulant agents might have decreased over the years.

Published
2020

12. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, primary, Kanzaki, Hiromitsu, additional, Inoue, Masafumi, additional, Ishiyama, Shuhei, additional, Yamauchi, Kenji, additional, Miyahara, Koji, additional, Toyokawa, Tatsuya, additional, Tsuzuki, Takao, additional, Miyaike, Jiro, additional, Matsubara, Minoru, additional, Takahashi, Sakuma, additional, Nishimura, Mamoru, additional, Takenaka, Ryuta, additional, Yunoki, Naoko, additional, Hori, Shinichiro, additional, Kobayashi, Sayo, additional, Yamasaki, Yasushi, additional, Kawahara, Yoshiro, additional, Ishikawa, Hideki, additional, and Okada, Hiroyuki, additional

Published
2020
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15. Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

Author

Iwamuro, Masaya, primary, Miyahara, Koji, additional, Sakaguchi, Chihiro, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Mouri, Hirokazu, additional, Tanaka, Shigetomi, additional, Toyokawa, Tatsuya, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Yamauchi, Kenji, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2020
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19. Clinical utility of serum fucosylated hemopexin in Japanese patients with hepatocellular carcinoma

Author

Kobayashi, Sayo, Nouso, Kazuhiro, Kinugasa, Hideaki, Takeuchi, Yasuto, Tomoda, Takeshi, Miyahara, Koji, Hagihara, Hiroaki, Kuwaki, Kenji, Onishi, Hideki, Nakamura, Shinichiro, Ikeda, Fusao, Miyake, Yasuhiro, Shiraha, Hidenori, Takaki, Akinobu, and Yamamoto, Kazuhide

Subjects
glycosylation, biomarker, hepatocellular carcinoma, fucosylated hemopexin, hypercarcinogenicity, digestive system diseases
Abstract

Aim: Hepatocellular carcinoma (HCC) is a common clinical problem all over the world. Fucosylated hemopexin (Fuc-Hpx) is a newly reported glycoprotein for the diagnosis of HCC, however, its clinical implications are unclear. The aim of this study was to elucidate the clinical utility of Fuc-Hpx in Japanese patients with HCC. Methods: The sera from 331 HCC patients, 45 with liver cirrhosis (LC), 85 with chronic hepatitis (CH) and 22 healthy people were examined for the expression of Fuc-Hpx; the level was compared with clinical parameters as well as hemopexin (Hpx) expression. The expressions of Fuc-Hpx in 12 HCC tissues and corresponding adjacent non-cancerous liver tissues were also examined. Results: No correlation was observed between Hpx and Fuc-Hpx level. The median Fuc-Hpx levels in healthy people and CH, LC and HCC patients were 3.8, 3.7, 6.1 and 7.6 AU/mL, respectively (CH vs LC, P = 0.002; CH vs HCC, P < 0.001; LC vs HCC, P = 0.02). Multivariate analysis revealed that low albumin, low prothrombin time and the presence of HCC were significantly correlated with high Fuc-Hpx (P = 0.013, =0.001 and

Published
2012

20. Su2023 Changes of Immunoglobulin-Bound Glycans in Patients With Gastro-Intestinal Cancers

Author

Dohi, Chihiro, primary, Nouso, Kazuhiro, additional, Ako, Soichiro, additional, Morimoto, Yuuki, additional, Miyahara, Koji, additional, Kinugasa, Hideaki, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2016
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23. Su1459 Serum N-Glycan Profiles in Patients With Intraductal Papillary Mucinous Neoplasms of Pancreas

Author

Akimoto, Yutaka, primary, Nouso, Kazuhiro, additional, Kato, Hironari, additional, Miyahara, Koji, additional, Dohi, Chihiro, additional, Morimoto, Yuki, additional, Kinugasa, Hideaki, additional, Tomoda, Takeshi, additional, Yamamoto, Naoki, additional, Tsutsumi, Koichiro, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Okada, Hiroyuki, additional, Amano, Maho, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2015
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24. Sa1844 Alteration of Serum N-Glycan Profile in Patients With Hepatocellular Carcinoma and Their Clinical Application

Author

Nouso, Kazuhiro, primary, Miyahara, Koji, additional, Dohi, Chihiro, additional, Morimoto, Yuki, additional, Kinugasa, Hideaki, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Amano, Maho, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2015
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26. Serum Glycan Markers for Evaluation of Disease Activity and Prediction of Clinical Course in Patients with Ulcerative Colitis

Author

Miyahara, Koji, primary, Nouso, Kazuhiro, additional, Saito, Shunsuke, additional, Hiraoka, Sakiko, additional, Harada, Keita, additional, Takahashi, Sakuma, additional, Morimoto, Yuki, additional, Kobayashi, Sayo, additional, Ikeda, Fusao, additional, Miyake, Yasuhiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Okada, Hiroyuki, additional, Amano, Maho, additional, Hirose, Kazuko, additional, Nishimura, Shin-Ichiro, additional, and Yamamoto, Kazuhide, additional

Published
2013
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28. A case of hepatocellular carcinoma with skin injury of the upper abdominal wall after transcatheter arterial chemoembolization: a case report

Author

Kanzaki, Hiromitsu, primary, Nouso, Kazuhiro, additional, Miyahara, Koji, additional, Kajikawa, Naoko, additional, Kobayashi, Sayo, additional, Sakakihara, Ichiro, additional, Iwadow, Shota, additional, Uematsu, Shuji, additional, Okamoto, Ryoichi, additional, Shiraga, Kunihiro, additional, Mizuno, Motowo, additional, and Araki, Yasuyuki, additional

Published
2009
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29. Development of a new television set with personal computer...

Author

Miyahara, Koji and Inoue, Sadayuki

Subjects
*TELEVISION, *PERSONAL computers
Abstract

Presents a prototype of a novel television set (TV) with personal computer (PC) capability. Overview of the system; User interface of the television set; Functions of a mediator board; Conclusion.

Published
1997
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30. Endoscopic Manifestations and Clinical Characteristics of Localized Gastric Light-Chain Amyloidosis.

Author

Iwamuro M, Tanaka S, Toyokawa T, Nishimura M, Tsuzuki T, Miyahara K, Negishi S, Ohya S, Tanaka T, and Otsuka M

Subjects
Male, Female, Humans, Retrospective Studies, Immunoglobulin Light-chain Amyloidosis diagnosis, Amyloidosis diagnosis, Amyloidosis pathology, Stomach Diseases diagnosis, Stomach Diseases pathology
Abstract

To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2023
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