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Your search keyword '"Millar, Douglas G."' showing total 16 results
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16 results on '"Millar, Douglas G."'

1. Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire

Author

Millar, Douglas G., Yang, S. Y. Cindy, Sayad, Azin, Zhao, Qingchuan, Nguyen, Linh T., Warner, Kathrin, Sangster, Ami G., Nakatsugawa, Munehide, Murata, Kenji, Wang, Ben X., Shaw, Patricia, Clarke, Blaise, Bernardini, Marcus Q., Pugh, Trevor, Thibault, Pierre, Hirano, Naoto, Perreault, Claude, and Ohashi, Pamela S.

Published
2023
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2. Abstract A074: Maveropepimut-S, a DPX-based immune-educating therapy, combined with Pembrolizumab and Cyclophosphamide in recurrent ovarian cancer, results from the Phase 1/2 PESCO Trial

Author

Veneziani, Ana C., primary, Alqaisi, Husam, additional, Millar, Douglas G, additional, Colombo, Ilaria, additional, Gonzalez-Ochoa, Eduardo, additional, Atale, Swati, additional, Msan, Anthony, additional, Quintos, Judy, additional, Ramsahai, Janelle, additional, Garg, Vikas, additional, Soberanis, Pamela, additional, Dhani, Neesha C, additional, Grant, Robert C, additional, Wang, Lisa, additional, Bowering, Valerie, additional, Lheureux, Stephanie, additional, Ohashi, Pamela S, additional, and Oza, Amit M, additional

Published
2024
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5. Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Author

Millar, Douglas G, Garza, Kristine M, Odermatt, Bernhard, Elford, Alisha R, Ono, Nobuyuki, Li, Zihai, and Ohashi, Pamela S

Abstract

Pathogens or pathogen-associated molecular patterns can signal to cells of the innate immune system and trigger effective adaptive immunity. However, relatively little is known about how the innate immune system detects tissue injury or necrosis. Evidence suggests that the release of heat-shock proteins (HSPs) may provide adjuvant-like signals, but the ability of HSPs to promote activation or tolerance in vivo has not been addressed. In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo., Author(s): Douglas G Millar [1]; Kristine M Garza [2]; Bernhard Odermatt [3]; Alisha R Elford [1]; Nobuyuki Ono [1]; Zihai Li [4]; Pamela S Ohashi (corresponding author) [1] Initiation of [...]

Published
2003
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6. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Author

Suzuki, Nobutaka, Suzuki, Shinobu, Duncan, Gordon S., Millar, Douglas G., Wada, Teiji, Mirtsos, Christine, Takada, Hidetoshi, Wakeham, Andrew, Itie, Annick, Li, Shyun, Penninger, Josef M., Wesche, Holger, Ohashi, Pamela S., Mak, Tak W., and Yeh, Wen-Chen

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Nobutaka Suzuki [1, 2]; Shinobu Suzuki [1, 2]; Gordon S. Duncan [1]; Douglas G. Millar [3]; Teiji Wada [1]; Christine Mirtsos [1]; Hidetoshi Takada [1]; Andrew Wakeham [1]; Annick [...]

Published
2002
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7. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

Author

Ruland, Jurgen, Duncan, Gordon S., Elia, Andrew, Barrantes, Ivan del Barco, Nguyen, Linh, Plyte, Sue, Millar, Douglas G., Bouchard, Denis, and Wakeham, Andrew

Subjects
Immunogenetics -- Research, Neural tube -- Genetic aspects, Lymphocytes -- Physiological aspects, Cellular signal transduction -- Physiological aspects, B cells -- Physiological aspects, T cells -- Physiological aspects, Biological sciences
Abstract

The mucosa-associated lymphoid tissue protein Bcl10, containing an N-terminal caspase recruitment domain, regulates lymphocyte proliferation, connecting antigen receptor signaling in B and T lymphocytes to NF-kappaB activation. Data point out that Bcl10 is also involved in neural tube closure.

Published
2001

8. Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma

Author

Murata, Kenji, primary, Nakatsugawa, Munehide, additional, Rahman, Muhammed A, additional, Nguyen, Linh T, additional, Millar, Douglas G, additional, Mulder, David T, additional, Sugata, Kenji, additional, Saijo, Hiroshi, additional, Matsunaga, Yukiko, additional, Kagoya, Yuki, additional, Guo, Tingxi, additional, Anczurowski, Mark, additional, Wang, Chung-Hsi, additional, Burt, Brian D, additional, Ly, Dalam, additional, Saso, Kayoko, additional, Easson, Alexandra, additional, Goldstein, David P, additional, Reedijk, Michael, additional, Ghazarian, Danny, additional, Pugh, Trevor J, additional, Butler, Marcus O, additional, Mak, Tak W, additional, Ohashi, Pamela S, additional, and Hirano, Naoto, additional

Published
2020
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16. Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of Δ mas20 in yeast

Author

Swie Goping, Ing, Millar, Douglas G., and Shore, Gordon C.

Abstract

The human homolog of the S. cerevisiaelN. crassamitochondrial protein import receptor, Mas20p/MOM19, has been identified and characterized. Sequence similarities between these three proteins is most pronounced within the NH 2-terminal third of the molecules. However, the mammalian protein exhibits only weak homology to the tetratricopeptide repeat B domain that is found in Mas20p/MOM19. huMas20p is targeted and inserted into the outer membrane of isolated rat heart mitochondria, in the N inC cytoorientation. Antibodies directed against the soluble portion of huMas20p inhibited in vitro mitochondrial import of a diverse set of precursor proteins (including inner membrane uncoupling protein), but failed to block import of a fusion protein bearing the signal-anchor sequence of Mas20p itself. Finally, expression of huMAS20complemented the respiratory defect of Δ mas20yeast cells. Together, these results demonstrate that huMAS20p is a component of the mammalian import apparatus.

Published
1995
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