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Your search keyword '"Memnoniella"' showing total 11 results
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11 results on '"Memnoniella"'

1. Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171.

Author

Annang, Frederick Boye, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, González-Menéndez, Victor, Martín, Jesús, Mackenzie, Thomas A., Ramos, Maria C., Ruiz-Pérez, Luis M., Genilloud, Olga, González-Pacanowska, Dolores, Vicente, Francisca, and Reyes, Fernando

Subjects
*NUCLEAR magnetic resonance spectroscopy, *LIVER cells, *BIOACTIVE compounds, *HIGH throughput screening (Drug development)
Abstract

Memnoniella is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A Memnoniella dichroa CF-080171 extract was identified to exhibit potent activity against Plasmodium falciparum 3D7 and Trypanosoma cruzi Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundación MEDINA's collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (1–3), a glycosylated isobenzofuranone (4), a tricyclic isobenzofuranone (5), a tetracyclic benzopyrane (6), a tetracyclic isobenzofuranone (7), and a pentacyclic isobenzofuranone (8). The structures of the isolated compounds were established by (+)-ESI-TOF high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Compounds 1, 2, and 4 exhibited potent antiparasitic activity against P. falciparum 3D7 (EC50 0.04–0.243 μM) and T. cruzi Tulahuen (EC50 0.266–1.37 μM) parasites, as well as cytotoxic activity against HepG2 tumoral liver cells (EC50 1.20–4.84 μM). The remaining compounds (3, 5–8) showed moderate or no activity against the above-mentioned parasites and cells. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171

Author

Frederick Boye Annang, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Victor González-Menéndez, Jesús Martín, Thomas A. Mackenzie, Maria C. Ramos, Luis M. Ruiz-Pérez, Olga Genilloud, Dolores González-Pacanowska, Francisca Vicente, and Fernando Reyes

Subjects
natural products, meroterpenoids, Memnoniella, parasites, tropical diseases, bioassay-guided isolation, Pharmacy and materia medica, RS1-441
Abstract

Memnoniella is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A Memnoniella dichroa CF-080171 extract was identified to exhibit potent activity against Plasmodium falciparum 3D7 and Trypanosoma cruzi Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundación MEDINA’s collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (1–3), a glycosylated isobenzofuranone (4), a tricyclic isobenzofuranone (5), a tetracyclic benzopyrane (6), a tetracyclic isobenzofuranone (7), and a pentacyclic isobenzofuranone (8). The structures of the isolated compounds were established by (+)-ESI-TOF high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Compounds 1, 2, and 4 exhibited potent antiparasitic activity against P. falciparum 3D7 (EC50 0.04–0.243 μM) and T. cruzi Tulahuen (EC50 0.266–1.37 μM) parasites, as well as cytotoxic activity against HepG2 tumoral liver cells (EC50 1.20–4.84 μM). The remaining compounds (3, 5–8) showed moderate or no activity against the above-mentioned parasites and cells.

Published
2023
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3. Memnoniella sinensis sp. nov., a new species from China and a key to species of the genus

Author

Hua Zheng, De-Zhen Liu, Zhe Zhang, and Zefen Yu

Subjects
0106 biological sciences, 0301 basic medicine, Phylogenetic tree, Genus Memnoniella, Dichroa, General Medicine, Sordariomycetes, Biology, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Microbiology, Conidium, 03 medical and health sciences, 030104 developmental biology, Phylogenetics, Botany, Taxonomy (biology), Memnoniella, Ecology, Evolution, Behavior and Systematics
Abstract

During a survey of fungal diversity in a deserted rocky area in Yunnan, PR China, a new species, Memnoniella sinensis, was identified. This new species is characterized by having phialidic conidiogenous cells with conspicuous collarettes, and aseptate, verrucose, ellipsoidal to sometimes ovoid, olivaceous brown to dark brown conidia. Morphologically, M. sinensis is similar to M. dichroa, but can be easily distinguished due to its hyaline conidiophores and smaller conidia. Phylogenetic analysis based on DNA sequences at five loci showed that our strain grouped together with M. dichroa and M. oenanthes. Here, the new species is described and illustrated, and a key to the species of the genus Memnoniella is provided.

Published
2019

4. Memnobotrins and Memnoconols. Novel Metabolites from Memnoniella echinata

Author

James C. Fettinger, Bruce B. Jarvis, Kim Dudley, and Simon F.R. Hinkley

Subjects
Pharmacology, Antibiotics, Antineoplastic, Stereochemistry, Chemistry, Molecular Conformation, Tumor cells, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Fermentation, Drug Discovery, Tumor Cells, Cultured, Humans, Mitosporic Fungi, Fatty Alcohols, Memnoniella echinata, Solvent extraction, Memnoniella, Benzofurans
Abstract

Four novel metabolites have been isolated from a rice culture of Memnoniella echinata (JS6308) by solvent extraction and radial silica chromatography. The structures were elucidated by spectroscopic techniques, and the absolute stereochemistry of memnobotrin A determined by X-ray crystallography.

Published
1999

5. The genus Stachybotrys (anamorphic fungi) in the semi-arid region of Brazil

Author

Marcos Fabio Oliveira Marques, Alisson Cardoso Rodrigues da Cruz, Luís Fernando Pascholati Gusmão, Sheila Miranda Leão Ferreira, Flavia Rodrigues Barbosa, and Tasciano dos Santos Santa Izabel

Subjects
Longispora, fungos conidiais, Stachybotrys, taxonomia, Biology, Plant litter, biology.organism_classification, conidial fungi, Arid, Conidium, taxonomy, Genus Stachybotrys, Botany, Key (lock), Taxonomy (biology), Memnoniella
Abstract

(The genus Stachybotrys (anamorphic fungi) in the semi-arid region of Brazil). Stachybotrys is characterized by macronematous, mononematous, unbranched or branched conidiophores, with discrete terminal and phialidic conidiogenous cells, and aseptate, reniform, ellipsoidal to spherical, smooth or verrucose conidia, which are produced in a slimy mass. Eight species have been reported from Brazil, occurring in the soil, air and leaf litter. During investigation of conidial fungi on decaying leaf litter in semi-arid areas of Brazil nine species were found: S. bisbyi (Sriniv.) G.L. Barron, S. chartarum (Ehrenb.) S. Hughes, S. globosa P. C. Misra & S. K. Srivast., S. kampalensis Hansf., S. longispora Matsush., S. nephrospora Hansf., S. nilagirica Subram., Stachybotrys parvispora S. Hughes and S. verrucispora Matsush. Stachybotrys nilagirica is a new record from Brazil. Descriptions, comments, geographic distribution and illustrations are presented for above mentioned species. A key for all species recorded in semi-arid region of Brazil is presented. (O gênero Stachybotrys (fungos anamórficos) na região semi-árida do Brasil). Stachybotrys é caracterizado por apresentar conidióforos macronemáticos, mononemáticos simples ou ramificados, células conidiogênicas evidentes, terminais e fialídicas e conídios asseptados, reniformes, elipsóides a esféricos, lisos ou verrucosos, produzidos em mucilagem. No Brasil já foram relatadas oito espécies, ocorrendo no solo, no ar e em material vegetal em decomposição. Durante investigação de fungos conidiais associados à serapilheira em áreas do semi-árido brasileiro foram encontradas nove espécies: S. bisbyi (Sriniv.) G.L. Barron, S. chartarum (Ehrenb.) S. Hughes, S. globosa P. C. Misra & S. K. Srivast., S. kampalensis Hansf., S. longispora Matsush., S. nephrospora Hansf., S. nilagirica Subram., S. parvispora S. Hughes e S. verrucispora Matsush., dentre estas S. nilagirica constitui um novo registro para o Brasil. Descrições, comentários, distribuição geográfica e ilustrações são apresentadas para as espécies citadas. Chave de identificação para as espécies registradas no Brasil é apresentada.

Published
2010

6. Memnoniella echinata

Author

J. L. Crane, J. L. Crane, J. L. Crane, and J. L. Crane

Abstract

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-329785%5DMICH-F-329785, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/329785/MICH-F-329785/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1991

7. The Ultrastructure of the Formation of Chains of Conidia inMemnoniella Echinata

Author

R. Campbell

Subjects
0106 biological sciences, 0301 basic medicine, Physiology, Ontogeny, Cell Biology, General Medicine, 030108 mycology & parasitology, Biology, 010603 evolutionary biology, 01 natural sciences, Persistence (computer science), Conidium, 03 medical and health sciences, Botany, Genetics, Ultrastructure, Memnoniella echinata, Molecular Biology, Memnoniella, Ecology, Evolution, Behavior and Systematics
Abstract

The conidial ontogeny of Memnoniella is very similar to that described for other phialidic Deuteromycotina. The persistence of the chain of conidia appears to be mostly due to the strength of the s...

Published
1975

8. THE VITAMIN REQUIREMENTS OF MEMNONIELLA AND STACHYBOTRYS

Author

Paul B. Marsh and Katharina Bollenbacher

Subjects
Vitamin, chemistry.chemical_compound, chemistry, Genetics, Stachybotrys, Plant Science, Biology, biology.organism_classification, Memnoniella, Ecology, Evolution, Behavior and Systematics, Microbiology
Published
1946

9. Isolates Intermediate Between Stachybotrys and Memnoniella

Author

Robert K. Zuck

Subjects
0106 biological sciences, 0301 basic medicine, Physiology, Stachybotrys, Cell Biology, General Medicine, 030108 mycology & parasitology, Biology, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Microbiology, Spore, 03 medical and health sciences, Genetics, Molecular Biology, Memnoniella, Ecology, Evolution, Behavior and Systematics
Abstract

1. Isolates of an intermediate nature between Memnoniella von Hohnel and Stachybotrys Corda have been observed.2. Stachybotrys-like slimy heads of elliptical to oval spores and Memnoniella-like hea...

Published
1946

10. Memnoniella subsimplex

Author

J. L. Crane, J. L. Crane, J. L. Crane, and J. L. Crane

Abstract

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-329787%5DMICH-F-329787, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/329787/MICH-F-329787/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1983

11. Memnoniella echinata

Author

W. B. Cooke, W. B. Cooke, W. B. Cooke, and W. B. Cooke

Abstract

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-329786%5DMICH-F-329786, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/329786/MICH-F-329786/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1944

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