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Egg production traits are crucial in the poultry industry, including age at first egg (AFE), egg number (EN) at different stages, and laying rate (LR). Ducks exhibit higher egg production capacity than other poultry species, but the genetic mechanisms are still poorly understood. In this study, we collected egg-laying data of 618 Peking ducks from 22 to 66 weeks of age and genotyped them by whole-genome resequencing. Genetic parameters were calculated based on SNPs, and a genome-wide association study (GWAS) was performed for these traits. The SNP-based heritability of egg production traits ranged from 0.09 to 0.54. The GWAS identified nine significant SNP loci associated with AFE and egg number from 22 to 66 weeks. These loci showed that the corresponding alleles were positively correlated with a decrease in the traits. Moreover, three potential candidate genes (ENSAPLG00020011445, ENSAPLG00020012564, TMEM260) were identified. Functional enrichment analyses suggest that specific immune responses may have a critical impact on egg production capacity by influencing ovarian function and oocyte maturation processes. In conclusion, this study deepens the understanding of egg-laying genetics in Peking duck and provides a sound theoretical basis for future genetic improvement and genomic selection strategies in poultry.

Objective To explore the impact of integrated health education based on WeChat "hospital-family" on exercise-minded patients with chronic heart failure. Methods One hundred and forty exercise-minded patients with CHF hospitalized in the Department of Cardiovascular Medicine from December 2019 to May 2020 were randomly divided into a control group (n=64) and an intervention group (n=65) according to the random number table method. The control group used the traditional preaching model, and the intervention group implemented the integrated hospital-family health education model based on WeChat. After 3 months of intervention, the self-efficacy, self-management ability, quality of life and exercise tolerance of the two groups were compared. Results Exercise-minded Patients in the intervention group had significantly higher dry strength, quality of life and exercise tolerance (P< 0.05). Conclusion WeChat-based integrated hospital-family health education can improve self-efficacy and self-management ability of CHF exercise-minded patients, thus improving quality of life cardiac function. [ABSTRACT FROM AUTHOR]