Search

Objective: The objective of this study was to associate the epidemiological and clinical characteristics of patients hospitalized for COVID-19 with the progression to critical illness and death in northwestern Mexico., Methods: From March to October 2020, we collected the demographic and clinical characteristics of 464 hospitalized patients from northwestern Mexico., Results: Sixty-four percent (295/464) of the patients became critically ill. Age, occupation, steroid and antibiotic use at previous hospitalization, and underlying diseases (hypertension, obesity, and chronic kidney disease) were associated with critical illness or death (p: < 0.05). No symptoms were associated with critical illness. However, the parameters such as the heart rate, respiratory rate, oxygen saturation, and diastolic pressure and the laboratory parameters such as the glucose, creatinine, white line cells, hemoglobin, D-dimer, and C-reactive protein, among others, were associated with critical illness (p: < 0.05). Finally, advanced age, previous hospital treatment, and the presence of one or more underlying diseases were associated with critical illness and death (p: < 0.02)., Conclusions: Several epidemiological (e.g., age and occupation) and clinical factors (e.g., previous treatment, underlying diseases, and vital signs and laboratory parameters) were associated with critical illness and death in patients hospitalized with COVID-19. These data provide us with possible markers to avoid critical illness or death from COVID-19 in our region., (© 2024 The Author(s). The Clinical Respiratory Journal published by John Wiley & Sons Ltd.)

The first cases of unexplained pneumonia were reported in Wuhan, China, in December of 2019. Later, a novel coronavirus (SARS-CoV-2) was identified as the causal agent of pneumonia. This virus has since spread to more than 180 countries and has been declared a pandemic by the World Health Organization. Herein, we aimed to determine the epidemiological and clinical characteristics of symptomatic patients with coronavirus disease 2019 (COVID-19) and the relationship between the influenza vaccine with a lower risk of severe COVID-19 infection in the state of Sinaloa. We collected demographic and clinical data of 4,040 patients with acute respiratory infections across Sinaloa state hospitals from February 28 to May 15, 2020. The prevalence of COVID-19 among hospitalized patients with respiratory symptoms in Sinaloa showed 45.2% of men were more affected than women ( p < 0.001), and people aged 40-49 years were the most affected. The main symptoms of COVID-19 infection were cough and fever ( p < 0.001), while hypertension, obesity, and type 2 diabetes were the chronic diseases associated with COVID-19 than non-COVID-19 ( p < 0.003). Healthcare workers were most likely to be infected compared to other occupations ( p < 0.001). The general lethality rate was 14.1%, and males >62 years were the ones who had a higher lethality rate ( p < 0.001); the aforementioned chronic diseases were related to higher lethality of COVID-19 ( p < 0.001). Likewise, higher lethality was seen in housewives and patient retirees/pensioners compared with other occupations ( p < 0.001). Finally, we found there was a relationship between influenza vaccination and a lower risk of severe COVID-19 infection and mortality ( p < 0.001). These findings showed that healthcare workers, men >62 years with chronic diseases, and retired people were most affected. Furthermore, the influenza vaccine could decrease the severeness of COVID-19 cases., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Angulo-Zamudio, Martínez-Villa, Leon-Sicairos, Flores-Villaseñor, Velazquez-Roman, Campos-Romero, Alcántar-Fernández, Urrea, Muro-Amador, Medina-Serrano, Martinez-Garcia, Sanchez-Cuen, Angulo-Rocha and Canizalez-Roman.)