Search

Your search keyword '"Mcmichael, Andrew"' showing total 1,033 results
Start Over Author "Mcmichael, Andrew" Search Limiters Available in Library Collection
1,033 results on '"Mcmichael, Andrew"'

1. Exploring synergies between B- and T-cell vaccine approaches to optimize immune responses against HIV-workshop report.

Author

Maciel, Milton, Amara, Rama, Bar, Katharine, Crotty, Shane, Deeks, Steven, Duplessis, Christopher, Gaiha, Gaurav, McElrath, M, McMichael, Andrew, Palin, Amy, Rutishauser, Rachel, Shapiro, Stuart, Smiley, Stephen, and DSouza, M

Abstract

The US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institute of Health (NIH), convened a virtual workshop on August 8-9th, 2023 to explore potential synergies between HIV vaccine approaches that are designed to induce cellular or humoral immune responses. The goal of this workshop was to review data on leading vaccine candidates and to discuss the best strategies for combining these approaches to optimize immunity against HIV. Here, we summarize the findings reviewed at the workshop and discuss the knowledge gaps and priorities for future studies that will help accelerate the development of a preventive HIV vaccine.

Published
2024

5. Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides

Author

Yang, Xinbo, Garner, Lee I., Zvyagin, Ivan V., Paley, Michael A., Komech, Ekaterina A., Jude, Kevin M., Zhao, Xiang, Fernandes, Ricardo A., Hassman, Lynn M., Paley, Grace L., Savvides, Christina S., Brackenridge, Simon, Quastel, Max N., Chudakov, Dmitriy M., Bowness, Paul, Yokoyama, Wayne M., McMichael, Andrew J., Gillespie, Geraldine M., and Garcia, K. Christopher

Published
2022
Full Text
View/download PDF

7. Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

Author

Li, Dapeng, Brackenridge, Simon, Walters, Lucy C., Swanson, Olivia, Harlos, Karl, Rozbesky, Daniel, Cain, Derek W., Wiehe, Kevin, Scearce, Richard M., Barr, Maggie, Mu, Zekun, Parks, Robert, Quastel, Max, Edwards, Robert J., Wang, Yunfei, Rountree, Wes, Saunders, Kevin O., Ferrari, Guido, Borrow, Persephone, Jones, E. Yvonne, Alam, S. Munir, Azoitei, Mihai L., Gillespie, Geraldine M., McMichael, Andrew J., and Haynes, Barton F.

Published
2022
Full Text
View/download PDF

9. Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable.

Author

Barton, John P, Goonetilleke, Nilu, Butler, Thomas C, Walker, Bruce D, McMichael, Andrew J, and Chakraborty, Arup K

Subjects
Humans, HIV, HIV Infections, Polyproteins, Evolution, Molecular, Immunity, Cellular, Models, Genetic, Female, Male, Human Immunodeficiency Virus Proteins, Genetic Fitness, Evolution, Molecular, Immunity, Cellular, Models, Genetic
Abstract

Human immunodeficiency virus (HIV) evolves within infected persons to escape being destroyed by the host immune system, thereby preventing effective immune control of infection. Here, we combine methods from evolutionary dynamics and statistical physics to simulate in vivo HIV sequence evolution, predicting the relative rate of escape and the location of escape mutations in response to T-cell-mediated immune pressure in a cohort of 17 persons with acute HIV infection. Predicted and clinically observed times to escape immune responses agree well, and we show that the mutational pathways to escape depend on the viral sequence background due to epistatic interactions. The ability to predict escape pathways and the duration over which control is maintained by specific immune responses open the door to rational design of immunotherapeutic strategies that might enable long-term control of HIV infection. Our approach enables intra-host evolution of a human pathogen to be predicted in a probabilistic framework.

Published
2016

10. Contribution of proteasome-catalyzed peptide cis -splicing to viral targeting by CD8⁺ T cells in HIV-1 infection

Author

Paes, Wayne, Leonov, German, Partridge, Thomas, Chikata, Takayuki, Murakoshi, Hayato, Frangou, Anna, Brackenridge, Simon, Nicastri, Annalisa, Smith, Andrew G., Learn, Gerald H., Li, Yingying, Parker, Robert, Oka, Shinichi, Pellegrino, Pierre, Williams, Ian, Haynes, Barton F., McMichael, Andrew J., Shaw, George M., Hahn, Beatrice H., Takiguchi, Masafumi, Ternette, Nicola, and Borrow, Persephone

Published
2019

13. The Challenges of an HIV Vaccine Enterprise

Author

Zinkernagel, Rolf M., Wolf, Hans, Klausner, Richard D., Fauci, Anthony S., Corey, Lawrence, Nabel, Gary J., Gayle, Helene, Berkley, Seth, Haynes, Barton F., Baltimore, David, Collins, Chris, Douglas, R. Gordon, Esparza, Jose, Francis, Donald P., Ganguly, N. K., Gerberding, Julie Louise, Johnson, Margaret I., Kazatchkine, Michel D., McMichael, Andrew J., Makgoba, Malegapuru W., Pantaleo, Giuseppe, Piot, Peter, Shao, Yiming, Tramont, Edmund, Varmus, Harold, and Wasserheit, Judith N.

Published
2004

14. Common genetic variation and the control of HIV-1 in humans.

Author

Fellay, Jacques, Ge, Dongliang, Shianna, Kevin V, Colombo, Sara, Ledergerber, Bruno, Cirulli, Elizabeth T, Urban, Thomas J, Zhang, Kunlin, Gumbs, Curtis E, Smith, Jason P, Castagna, Antonella, Cozzi-Lepri, Alessandro, De Luca, Andrea, Easterbrook, Philippa, Günthard, Huldrych F, Mallal, Simon, Mussini, Cristina, Dalmau, Judith, Martinez-Picado, Javier, Miro, José M, Obel, Niels, Wolinsky, Steven M, Martinson, Jeremy J, Detels, Roger, Margolick, Joseph B, Jacobson, Lisa P, Descombes, Patrick, Antonarakis, Stylianos E, Beckmann, Jacques S, O'Brien, Stephen J, Letvin, Norman L, McMichael, Andrew J, Haynes, Barton F, Carrington, Mary, Feng, Sheng, Telenti, Amalio, Goldstein, David B, and NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)

Subjects
NIAID Center for HIV/AIDS Vaccine Immunology, Humans, HIV-1, HIV Infections, Disease Progression, Viral Load, Major Histocompatibility Complex, Genotype, Phenotype, Polymorphism, Single Nucleotide, Alleles, Adult, Female, Male, Genetic Variation, Kaplan-Meier Estimate, Polymorphism, Single Nucleotide, Genetics, Developmental Biology
Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Published
2009

15. The Need for a Global HIV Vaccine Enterprise

Author

Klausner, Richard D., Fauci, Anthony S., Corey, Lawrence, Nabel, Gary J., Gayle, Helene, Berkley, Seth, Haynes, Barton F., Baltimore, David, Collins, Chris, Douglas, R. Gordon, Esparza, Jose, Francis, Donald P., Ganguly, N. K., Gerberding, Julie Louise, Johnston, Margaret I., Kazatchkine, Michel D., McMichael, Andrew J., Makgoba, Malegapuru W., Pantaleo, Giuseppe, Piot, Peter, Shao, Yiming, Tramont, Edmund, Varmus, Harold, and Wasserheit, Judith N.

Published
2003

16. Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

Author

Hegazy, Ahmed N., West, Nathaniel R., Stubbington, Michael J.T., Wendt, Emily, Suijker, Kim I.M., Datsi, Angeliki, This, Sebastien, Danne, Camille, Campion, Suzanne, Duncan, Sylvia H., Owens, Benjamin M.J., Uhlig, Holm H., McMichael, Andrew, Bergthaler, Andreas, Teichmann, Sarah A., Keshav, Satish, and Powrie, Fiona

Published
2017
Full Text
View/download PDF

19. Preexisting memory CD[4.sup.+] T cells contribute to the primary response in an HIV-1 vaccine trial

Author

Campion, Suzanne L., Brenna, Elena, Thomson, Elaine, Fischer, Will, Ladell, Kristin, McLaren, James E., Price, David A., Frahm, Nicole, McElrath, Juliana M., Cohen, Kristen W., Maenza, Janine R., Walsh, Stephen R., Baden, Lindsey R., Haynes, Barton F., Korber, Bette, Borrow, Persephone, and McMichael, Andrew J.

Subjects
T cells -- Analysis, Immune response -- Analysis, Peptides -- Analysis, AIDS vaccines -- Testing, Health care industry
Abstract

Naive and memory CD[4.sup.+] T cells reactive with human immunodeficiency virus type 1 (HIV-1) are detectable in unexposed, unimmunized individuals. The contribution of preexisting CD[4.sup.+] T cells to a primary immune response was investigated in 20 HIV-1-seronegative volunteers vaccinated with an HIV-1 envelope (Env) plasmid DNA prime and recombinant modified vaccinia virus Ankara (MVA) boost in the HVTN 106 vaccine trial (clinicaltrials.gov NCT02296541). Prevaccination naive or memory CD[4.sup.+] T cell responses directed against peptide epitopes in Env were identified in 14 individuals. After priming with DNA, 40% (8/20) of the elicited responses matched epitopes detected in the corresponding preimmunization memory repertoires, and clonotypes were shared before and after vaccination in 2 representative volunteers. In contrast, there were no shared epitope specificities between the preimmunization memory compartment and responses detected after boosting with recombinant MVA expressing a heterologous Env. Preexisting memory CD[4.sup.+] T cells therefore shape the early immune response to vaccination with a previously unencountered HIV-1 antigen., Introduction The T cell clonotype repertoire expresses a vast array of receptors that can bind epitopes from almost any foreign immunogen (1). However, immune responses following immunization or infection often [...]

Published
2021
Full Text
View/download PDF

20. Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape.

Author

Karlsson, Annika C, Iversen, Astrid KN, Chapman, Joan M, de Oliviera, Tulio, Spotts, Gerald, McMichael, Andrew J, Davenport, Miles P, Hecht, Frederick M, and Nixon, Douglas F

Subjects
T-Lymphocytes, Cytotoxic, Humans, HIV-1, HIV Infections, Disease Progression, Tumor Necrosis Factor-alpha, HLA-A2 Antigen, HIV Antigens, Epitopes, Amino Acid Substitution, Sequence Alignment, Evolution, Molecular, Phylogeny, Base Sequence, Consensus Sequence, Sequence Homology, Nucleic Acid, Molecular Sequence Data, Female, Male, gag Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus, nef Gene Products, Human Immunodeficiency Virus, Interferon-gamma, Immune Evasion, T-Lymphocytes, Cytotoxic, Evolution, Molecular, Sequence Homology, Nucleic Acid, gag Gene Products, Human Immunodeficiency Virus, pol Gene Products, nef Gene Products, General Science & Technology
Abstract

BackgroundAntigen-specific CTL responses are thought to play a central role in containment of HIV-1 infection, but no consistent correlation has been found between the magnitude and/or breadth of response and viral load changes during disease progression.Methods and findingsWe undertook a detailed investigation of longitudinal CTL responses and HIV-1 evolution beginning with primary infection in 11 untreated HLA-A2 positive individuals. A subset of patients developed broad responses, which selected for consensus B epitope variants in Gag, Pol, and Nef, suggesting CTL-induced adaptation of HIV-1 at the population level. The patients who developed viral escape mutations and broad autologous CTL responses over time had a significantly higher increase in viral load during the first year of infection compared to those who did not develop viral escape mutations.ConclusionsA continuous dynamic development of CTL responses was associated with viral escape from temporarily effective immune responses. Our results suggest that broad CTL responses often represent footprints left by viral CTL escape rather than effective immune control, and help explain earlier findings that fail to show an association between breadth of CTL responses and viral load. Our results also demonstrate that CTL pressures help to maintain certain elements of consensus viral sequence, which likely represent viral escape from common HLA-restricted CTL responses. The ability of HIV to evolve to escape CTL responses restricted by a common HLA type highlights the challenges posed to development of an effective CTL-based vaccine.

Published
2007

25. Intracellular trafficking of HLA-E and its regulation

Author

He, Wanlin, primary, Gea-Mallorquí, Ester, additional, Colin-York, Huw, additional, Fritzsche, Marco, additional, Gillespie, Geraldine M., additional, Brackenridge, Simon, additional, Borrow, Persephone, additional, and McMichael, Andrew J., additional

Published
2023
Full Text
View/download PDF

28. HIV-1 Evolution and Disease Progression

Author

Nowak, Martin A., Anderson, Roy M., Boerlijst, Maarten C., Bonhoeffer, Sebastian, May, Robert M., McMichael, Andrew J., Wolinsky, Steven M., Kunstman, Kevin J., Safrit, Jeffrey T., Koup, Richard A., and Neumann, Avidan U.

Published
1996

32. HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

Author

Appay, Victor, Nixon, Douglas F, Donahoe, Sean M, Gillespie, Geraldine MA, Dong, Tao, King, Abigail, Ogg, Graham S, Spiegel, Hans ML, Conlon, Christopher, Spina, Celsa A, Havlir, Diane V, Richman, Douglas D, Waters, Anele, Easterbrook, Philippa, McMichael, Andrew J, and Rowland-Jones, Sarah L

Subjects
Infectious Diseases, Clinical Research, HIV/AIDS, Vaccine Related, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Infection, Good Health and Well Being, CD8-Positive T-Lymphocytes, Chemokine CCL4, Clone Cells, Cytokines, Cytomegalovirus, Flow Cytometry, HIV, HIV Infections, HIV Seronegativity, Histocompatibility Antigens Class I, Humans, Interferon-gamma, Macrophage Inflammatory Proteins, Reference Values, T-Lymphocytes, Cytotoxic, Tumor Necrosis Factor-alpha, cytotoxic T lymphocytes, cytokines, tetramers, perforin, Medical and Health Sciences, Immunology
Abstract

The use of peptide-human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8(+) T cells has provided a major development in our understanding of their role in controlling viral infections. However, questions remain about the exact function of these cells, particularly in HIV infection. Virus-specific cytotoxic T lymphocytes exert much of their activity by secreting soluble factors such as cytokines and chemokines. We describe here a method that combines the use of tetramers and intracellular staining to examine the functional heterogeneity of antigen-specific CD8(+) T cells ex vivo. After stimulation by specific peptide antigen, secretion of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1beta, and perforin is analyzed by FACS((R)) within the tetramer-positive population in peripheral blood. Using this method, we have assessed the functional phenotype of HIV-specific CD8(+) T cells compared with cytomegalovirus (CMV)-specific CD8(+) T cells in HIV chronic infection. We show that the majority of circulating CD8(+) T cells specific for CMV and HIV antigens are functionally active with regards to the secretion of antiviral cytokines in response to antigen, although a subset of tetramer-staining cells was identified that secretes IFN-gamma and MIP-1beta but not TNF-alpha. However, a striking finding is that HIV-specific CD8(+) T cells express significantly lower levels of perforin than CMV-specific CD8(+) T cells. This lack of perforin is linked with persistent CD27 expression on HIV-specific cells, suggesting impaired maturation, and specific lysis ex vivo is lower for HIV-specific compared with CMV-specific cells from the same donor. Thus, HIV-specific CD8(+) T cells are impaired in cytolytic activity.

Published
2000

33. Tetrameric Complexes of Human Histocompatibility Leukocyte Antigen (HLA)-G Bind to Peripheral Blood Myelomonocytic Cells

Author

Allan, David SJ, Colonna, Marco, Lanier, Lewis L, Churakova, Tatyana D, Abrams, John S, Ellis, Shirley A, McMichael, Andrew J, and Braud, Veronique M

Subjects
Pediatric, Clinical Research, Vaccine Related, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Animals, Biopolymers, Cell Line, HLA Antigens, HLA-G Antigens, Histocompatibility Antigens Class I, Humans, Jurkat Cells, Killer Cells, Natural, Lipopolysaccharide Receptors, Macromolecular Substances, Membrane Glycoproteins, Mice, Monocytes, Protein Binding, Protein Conformation, Rats, Receptors, IgG, Receptors, Immunologic, Receptors, KIR, Recombinant Fusion Proteins, Transfection, immunoglobulin-like transcript, monocyte, natural killer cell, CD94, killer immunoglobulin-like receptor, Medical and Health Sciences, Immunology
Abstract

The nonclassical MHC class I molecule human histocompatibility leukocyte antigen (HLA)-G is selectively expressed on fetal trophoblast tissue at the maternal-fetal interface in pregnancy. It has long been suggested that HLA-G may inhibit maternal natural killer (NK) cells through interaction with particular NK cell receptors (KIRs). To investigate interactions of HLA-G, we constructed phycoerythrin-labeled tetrameric complexes of HLA-G refolded with a self-peptide. These HLA-G tetramers failed to bind to NK cells and cells transfected with CD94/NKG2 and killer immunoglobulin-like NK receptors. In contrast, HLA-G tetramers did bind to peripheral blood monocytes, staining a CD16(+)CD14(mid) subset with greater intensity. On transfectants, HLA-G tetramers bound to inhibitory immunoglobulin-like transcript (ILT)2 and ILT4 receptors. However, staining in the presence of antibodies reactive with ILT receptors revealed that the interaction of HLA-G tetramers with blood monocytes was largely due to binding to ILT4. These results suggest that the primary role of HLA-G may be the modulation of myelomonocytic cell behavior in pregnancy.

Published
1999

37. Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Author

Walters, Lucy C., Harlos, Karl, Brackenridge, Simon, Rozbesky, Daniel, Barrett, Jordan R., Jain, Vitul, Walter, Thomas S., O’Callaghan, Chris A., Borrow, Persephone, Toebes, Mireille, Hansen, Scott G., Sacha, Jonah B., Abdulhaqq, Shaheed, Greene, Justin M., Früh, Klaus, Marshall, Emily, Picker, Louis J., Jones, E. Yvonne, McMichael, Andrew J., and Gillespie, Geraldine M.

Published
2018
Full Text
View/download PDF

38. Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Author

Walters, Lucy C., Harlos, Karl, Brackenridge, Simon, Rozbesky, Daniel, Barrett, Jordan R., Jain, Vitul, Walter, Thomas S., O’Callaghan, Chris A., Borrow, Persephone, Toebes, Mireille, Hansen, Scott G., Sacha, Jonah B, Abdulhaqq, Shaheed, Greene, Justin M., Früh, Klaus, Marshall, Emily, Picker, Louis J., Jones, E. Yvonne, McMichael, Andrew J., and Gillespie, Geraldine M.

Published
2018
Full Text
View/download PDF

39. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

Author

Song, Hongshuo, Giorgi, Elena E., Ganusov, Vitaly V., Cai, Fangping, Athreya, Gayathri, Yoon, Hyejin, Carja, Oana, Hora, Bhavna, Hraber, Peter, Romero-Severson, Ethan, Jiang, Chunlai, Li, Xiaojun, Wang, Shuyi, Li, Hui, Salazar-Gonzalez, Jesus F., Salazar, Maria G., Goonetilleke, Nilu, Keele, Brandon F., Montefiori, David C., Cohen, Myron S., Shaw, George M., Hahn, Beatrice H., McMichael, Andrew J., Haynes, Barton F., Korber, Bette, Bhattacharya, Tanmoy, and Gao, Feng

Published
2018
Full Text
View/download PDF

42. PC Games and the Teaching of History

Author

McMichael, Andrew

Abstract

Although the use of PC games in the history classroom might be relatively new, the ideas for these assignments and the theory behind their use borrows heavily from a number of areas and combines different pedagogical techniques. Using computer games allows teachers to recombine disparate teaching threads into something novel that will serve history education in a number of ways. In this article, the author explores the significance of using of PC games in the history classroom. The use of PC games in the history classroom can help students think about the relevance of history to their everyday lives, it can help them see the ways in which history gets exploited and sold to them in public, and it can assist them in realizing how history can have an impact on their lives long after they have left formal schoolwork. An educational experience using PC games can sharpen their analytical skills, something useful to them long after leaving the classroom. All of this can be accomplished while bringing an element of play into the work of studying. Teachers should not view PC games as a replacement for any of the already existing large array of teaching tools, but simply as the latest addition to an ongoing effort to present history in ways that enhance connections between what the students learn in the classroom and the ways in which they engage that learning in the outside world. (Contains 14 notes.)

Published
2007

45. GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans

Author

Yao, Yikun, primary, Du Jiang, Ping, additional, Chao, Brittany N., additional, Cagdas, Deniz, additional, Kubo, Satoshi, additional, Balasubramaniyam, Arasu, additional, Zhang, Yu, additional, Shadur, Bella, additional, NaserEddin, Adeeb, additional, Folio, Les R., additional, Schwarz, Benjamin, additional, Bohrnsen, Eric, additional, Zheng, Lixin, additional, Lynberg, Matthew, additional, Gottlieb, Simone, additional, Leney-Greene, Michael A., additional, Park, Ann Y., additional, Tezcan, Ilhan, additional, Akdogan, Ali, additional, Gocmen, Rahsan, additional, Onder, Sevgen, additional, Rosenberg, Avi, additional, Soilleux, Elizabeth J., additional, Johnson, Errin, additional, Jackson, Peter K., additional, Demeter, Janos, additional, Chauvin, Samuel D., additional, Paul, Florian, additional, Selbach, Matthias, additional, Bulut, Haydar, additional, Clatworthy, Menna R., additional, Tuong, Zewen K., additional, Zhang, Hanlin, additional, Stewart, Benjamin J., additional, Bosio, Catharine M., additional, Stepensky, Polina, additional, Clare, Simon, additional, Ganesan, Sundar, additional, Pascall, John C., additional, Daumke, Oliver, additional, Butcher, Geoffrey W., additional, McMichael, Andrew J., additional, Simon, Anna Katharina, additional, and Lenardo, Michael J., additional

Published
2022
Full Text
View/download PDF

50. A Step Ahead on the HIV Collaboratory

Author

Murphy, Robert L., Katlama, Christine, Debre, Patrice, Clotet, Bonaventura, Costagliola, Dominique, Dorrell, Lucy, Gatell, Jose, Klein, Michel, McMichael, Andrew J., Schacker, Timothy W., Walker, Bruce D., Autran, Brigitte, Brucker, Gilles, Calvez, Vincent, Clumeck, Nathan, Deeks, Steven G., Haase, Ashley, Lazzarin, Adriano, Papagno, Laura, Wain-Hobson, Simon, and Youle, Michael

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results