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2. #MeToo, Cisheteropatriarchy and LGBTQ plus Sexual Violence on Campus

Author

McCann, H, Sharp, M, McCann, H, and Sharp, M

Abstract

This article examines two case studies related to LGBTQ disclosures of sexual violence on university campuses, in the US and Australia. We argue that in a landscape of mediated #MeToo discourse, LGBTQ testimonies are often mapped onto a cisheteropatriarchal framework which limits adequate institutional responses to LGBTQ experiences of sexual violence. We illustrate how resolutions are often imagined via individualised empowerment narratives, and how this works in concert with the cisheteropatriarchal framing to delimit responses to sexual violence. We consider alternative possibilities for accounting for LGBTQ experiences going forward, and how institutions like universities might better respond to these issues.

Published
2023

5. Navigating “Normativity”: Kinship and Biphobia in Times of Crisis

Author

McCann, H and McCann, H

Abstract

As COVID-19 began to unfold, I found myself confronted with a second predicament: an identity crisis. After nearly a decade of dating queer-identifying people entered a partnership with an ostensibly straight cisgender man. Up to this moment I had thought of myself as loosely affiliated with the label of “bisexual”, but I often used the term “queer” as a way to signal my disinterest in occupying normative space. I also (regrettably) felt that this term distanced myself from my socially disparaged bisexual kin. ii Yet, as a cisgender woman dating a cisgender man, a seemingly “normative” partnership was precisely the location I began to occupy at the beginning of 2020. The wider context of the pandemic forced a shrinking of worlds and a return to the domestic. Local lockdowns escalated a sense of urgency around clarifying intimate personal networks. As such, the crisis context forced to me confront my internal battle around identity and normativity in a shrunken and hyper-domestic sphere. I wondered, with my so-called “opposite sex” partner staying with me in lockdown, was I suddenly living a heteronormative life? Where does bisexuality fit in to this question of normative sexual formations and partnerships? More generally, I wondered to what extent interpersonal arrangements that provide safety, security and comfort in times of crisis always align with the “normative”.

Published
2022

6. The Refusal to Refuse: Bisexuality Trouble and the Hegemony of Monosexuality

Author

McCann, H and McCann, H

Abstract

This paper both revisits and productively draws on Judith Butler’s theory of sexuality offered in Gender Trouble, to consider how this foundational queer theory text inadvertently works to contain and bracket plurisexualities such as bisexuality. I consider how Butler at once rejects the idea of originary bisexuality provoked by psychoanalytic discourse on polymorphous perversity yet subsumes bisexual oppression into that of homosexuality. I interrogate Butler’s monosexual presumptions to extend their notion of the heterosexual matrix to account for an operational hetero/homo binary that both excludes plurisexuality as its Other and obscures this exclusion. Following this theoretical line, I consider how the asymmetric hetero/homo binary has been coded along the lines of comedy/tragedy in culture, and in contrast how bisexuality and other plurisexualities are often rendered impossible. I suggest that plurisexualities, representing a refusal to refuse the originary prohibition, “haunt” both straight and queer contexts alike.

Published
2022

7. 'Helps me feel more like myself': navigating bodies, emotions and identity in Australian queer salons

Author

McCann, H and McCann, H

Abstract

While hair and beauty salons are often thought of as spaces that reproduce normative ideals of gender and sexuality, the past decade has seen an increase in salons catering specifically to LGBTQ+ clientele. More broadly, research has shown that far from only treating ‘surface’ concerns, salons in general are sites of intensified affect, making them a unique space of entangled body, emotional, and identity work. This article draws on interviews with salon workers from 2017 and client responses to a survey about salons during COVID-19 from 2020, conducted in Australia. This article gives particular focus to salons catering to the LGBTQ+ community (‘queer salons’), as well as data from salon clients that identify as LGBTQ+. Drawing on this dataset this article offers insight into how queer salons challenge our expectations of what hair and beauty salons can do for queer precarity in terms of physical, emotional and identity vulnerability and trouble ideas of the salon as a space which merely reinforces normative ideals of beauty. Furthermore, this article considers how salons might provide a sense of safety and belonging for some LGBTQ+ people, especially within the context of a pandemic.

Published
2022

8. Sensing the pandemic: revealing and re-ordering the senses

Author

Tullett, W, McCann, H, Tullett, W, and McCann, H

Abstract

This article reviews an assembled archive of the literature published to date on the sensory dimensions of the COVID-19 pandemic. Just as sensory scholars have often highlighted periods of sensory revolution, we find that the recent pandemic has augured some notable shifts, albeit often on the more micro and domestic scale. We present a five-sense sensorium that offers an overview of how the senses have been engaged with by scholars during the pandemic, and what the major issues and themes have been. Drawing on the literature, we suggest that there have been shifts in our sensate experiences and an increased awareness of the sensory dimensions of daily life that may usually go unnoticed. However, we also note the many sensory-related inequalities have been revealed over this period, which continue to unfold unevenly as the pandemic continues. We argue that going forward sensory scholars ought to attend to these questions of inequality, as well as tracking the possible undoing of some of the sensory revolutions that may have taken place so far.

Published
2022

9. 'Very unsure of what's to come': Salon worker experiences of COVID-19 in Australia during 2020

Author

McCann, H and McCann, H

Abstract

During Australia’s first nationwide lockdown due to COVID-19 in 2020, hairdressers and barbers were allowed to remain operating while beauty salons and similar businesses were ordered to shut. This article offers some preliminary insights into the impact of the pandemic on salon workers during the period, in particular the additional emotional labour required. Drawing on a survey of salon workers based in Australia ( n = 92), this article considers the emotional labour involved in salon work in tandem with the impact of COVID-19 disruptions on this workforce. Results of the survey reveal the variety of emotional disclosures that salon workers generally encounter from clients and how these disclosures continued during the period, as well as the emotions experienced by workers themselves. Survey results suggest that many salon workers, who were themselves experiencing heightened levels of physical, emotional and financial vulnerability, were expected to continue their emotional roles for clients during a period of high anxiety and stress. This work suggests that future decision making ought to consider the impact on, and how best to support, all workforces who remain in operation during lockdowns, particularly emotional labourers, and not just those typically imagined as ‘essential’.

Published
2022

12. Addressing the silence: Utilising salon workers to respond to family violence

Author

McCann, H, Myers, K, McCann, H, and Myers, K

Abstract

Community programs designed to train salon workers to address the issue of family violence are becoming increasingly commonplace. This article draws on interviews with trainees of one such program called HaiR-3Rs, run by the Eastern Domestic Violence Service (EDVOS) and launched in January 2018 in Victoria, Australia. HaiR-3Rs trains salon workers in recognising, responding to, and referring clients experiencing family violence. Using data collected from qualitative interviews this article reflects on trainee experiences of the HaiR-3Rs program. This article offers insights into whether training salon workers to respond to the issue of family violence places an additional burden of expectation on workers, as well as practical issues and limits of the training. The results of this study suggest that programs like HaiR-3Rs tap into deeper issues about the emotional nature of salon work, and has implications for the hair and beauty industry more broadly.

Published
2021

15. Splitting from Halley: Doing Justice to Race, Unwantedness, and Testimony in Campus Sexual Assault

Author

Kennedy, R, McCann, H, Kennedy, R, and McCann, H

Abstract

This article takes the documentary film The Hunting Ground, and the controversy it provoked, as a starting point for interrogating approaches to the representation and regulation of sexual assault on campus. We focus on the work of critical legal theorist Janet Halley, who has been a leading and contentious figure in advocating against the film and for a reconsideration of how Title IX is implemented on university campuses. In 2015, nineteen Harvard law professors, for whom Halley was the spokesperson, issued a press release objecting to the Hunting Ground for misrepresenting the case of one of their students.

Published
2020

16. Is there anything 'toxic' about femininity? The rigid femininities that keep us locked in

Author

McCann, H and McCann, H

Abstract

In recent years there has been rising popular discourse around ‘toxic masculinity’, and the problems of a hegemonic gender structure that facilitates male violence and misogyny. In the public debate over whether toxic masculinity is fact or fiction, ‘toxic femininity’ is often raised by men’s rights activists and others as an anti-feminist retort, to suggest that women can be ‘toxic’ too. This paper provides a sketch of how the term has been used so far, in tandem with an overview of the limitations of the more extensively discussed idea of ‘toxic masculinity’. This paper suggests that rather than deploying ‘toxic femininity’, it is more useful to consider what might be ‘toxic’ about some approaches to femininity. Drawing on existing theories of femininity, including emphasised, hegemonic, normative, patriarchal femininity, pariah femininities, and femmephobia, this paper offers the notion of ‘rigid femininities’ to explain the structures that keep us locked into a ‘toxic’ gender system. This paper utilises the term toxic femininity as a jumping-off point for theorising femininity broadly. In theorising femininity, this paper offers a conceptualisation of the ‘toxic’ attachments that reinforce the gendered power structure/essentialized gender.

Published
2020

17. ‘The Free-Flying Natural Woman Boobs of Yore’? the Body Beyond Representation in Feminist Accounts of Objectification

Author

McCann, H and McCann, H

Abstract

This article takes up references to breasts as a key case study to examine white Western feminist debate around embodiment and objectification. Tracking shifting understandings of ‘the gaze’ in these accounts, we find that objectification is often rendered singular, ahistorical and, increasingly, individually internalised. The history of these approaches to objectification helps to explain why during the early 2000s, theorisations of feminist politics-lost were often rhetorically located alongside discussions of surgically modified breasts as a symbol of a new era of ‘fake’ feminism. In contrast, the 2010s saw several feminist movements premised on exposure of flesh and claims to individual recuperation of bodily autonomy. This article contends that both of these perspectives rely on a notion, built over successive eras of white Western feminist thought, that political work can and ought to be done through the body as a site of representational politics. This article subsequently offers a brief insight into how we might queer our approach to breasts to better account for the messiness of experiences of the flesh, considering the personal as political, while not investing in the body as the site where politics must be enacted.

Published
2020

19. Queerbaiting and Real Person Slash: The Case of Larry Stylinson

Author

Brennan, J, Southerton, C, McCann, H, Brennan, J, Southerton, C, and McCann, H

Abstract

In this first-ever comprehensive examination of queerbaiting, fan studies scholar Joseph Brennan and his contributors examine cases that shed light on the sometimes exploitative industry practice of teasing homoerotic possibilities that, ...

Published
2019

20. Repetitions of desire queering the one direction fangirl

Author

McCann, H, Southerton, C, McCann, H, and Southerton, C

Abstract

Like other fangirls, fans of former boyband One Direction ("Directioners") have often been represented in media discourse as obsessive and hysterical, with fan behaviour interpreted as longing for heterosexual intimacy with band members. Subverting this heteronormative framing, a group of Directioners known as "Larries" have built a sub-fandom around imagining a relationship ("ship") between two of the band members, Harry Styles and Louis Tomlinson. Representation of the Larry fandom has gone beyond pathologizing fangirls to framing their shipping practice in terms of "fake news." The conspiracy theory panic around Larries misses the complex ways that subtext and queer reading are mobilized within the fandom to invoke feelings of queer intimacy and belonging. Drawing on a digital ethnography conducted on Twitter with Larries, we argue that these fans engage in queer reading strategies to explicitly imagine and interrupt dominant heterosexual narratives, and thus queer the figure of the fangirl.

Published
2019

21. ‘In this house we believe in fairness and kindness’: Post-liberation politics in Australia's same-sex marriage postal survey

Author

Thomas, A, McCann, H, Fela, G, Thomas, A, McCann, H, and Fela, G

Abstract

In December 2017, Australia legalized same-sex marriage (SSM), following a 13-year ban and a drawn-out postal survey on marriage equality that saw campaigners mobilize for a ‘Yes’ vote on a non-binding poll. Through a discourse analysis of the Yes and No campaigns’ television and online video advertisements, we demonstrate how the Yes campaign was symptomatic of what we call a ‘post-liberation’ approach that saw SSM as the last major hurdle for Lesbian, Gay, Bisexual, Transgender, Intersex and Queer (LGBTIQ) politics. While the No campaign linked SSM to gender fluidity, transgender identity, and sex education programmes, in contrast the Yes campaign limited itself to narratives around love and marriage. In not attending to the link between sex, gender and sexuality, the Yes campaign narrowed the possibilities of the debate, preserving existing White heteronormative expectations of gender and sexuality. We contrast the debate that unfolded during the postal survey to the Australian Gay Liberation movement of the 1970s, the latter of which was able to successfully and radically challenge similarly homophobic campaigns. Rather than relying on ‘palatable’ or mainstream ideas of equality, love and fairness, Gay Liberation in Australia embraced the radical potential of LGBTIQ activism and presented a utopian, optimistic vision of a transformed future. Here we suggest that we can learn from the history of campaigns around sexuality, to understand what was ‘won’ in the SSM debate, and to better develop strategies for change in the future.

Published
2019

23. Chemical Species Tomography from Spectral Optical Attenuation Data

Author

Polydorides, N. and McCann, H.

Abstract

We introduce a novel approach that casts a linear inverse problem for species concentration tomography from spectral data such as those acquired in wavelength modulation spectroscopy or direct absorption spectroscopy. Under isobaric measurement conditions and known plume temperature, our technique leads to a linear well-posed estimation problem for an extended data set derived from the direct absorption spectroscopy measurements. This allows imaging the concentration with enhanced noise robustness and spatial resolution that is significantly higher compared to previous methods for the same number of optical paths. We demonstrate the performance of our approach through proof-of-concept simulation for a carbon dioxide tomographic measurement.

Published
2018
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24. CIDAR : combustion species imaging diagnostics for aero-engine research

Author

Archilla, V., Aragón, G., Wright, P., Ozanyan, K., Black, J., Polydorides, N., McCann, H., Lengden, M., Burns, I., Johnstone, W., Polo, V., Beltran, M., Mauchline, I., Walsh, D., and Johnson, M.

Subjects
TL, TK
Abstract

Very high bypass ratio (VHBR) engines will realize significant environmental benefits as lower fuel consumption contributes to a reduction in CO2, NOx and non-volatile particulate matter (nvPM)/soot emission. VHBR engine performance tests will require representative CO2 measurement, and here we propose the use of a chemical species tomography (CST) measurement system to fully map the output CO2 from the engine core exhaust. In addition, we propose a technique allowing the 2D measurement of exhaust nvPM concentration that will provide an increased understanding of the complex injector-to-injector fuel flow variation, which impacts the temperature distribution through the turbine. This combined technological development in the CIDAR programme will produce an innovative step change in aircraft engine diagnostics, based on real-time, in-situ photonic technologies. This will increase the EU’s competitiveness in non-intrusive engine exhaust measurement systems for both engine performance evaluation and emissions quantification.

Published
2018

32. Implementation of Non-Intrusive Jet Exhaust Species Distribution Measurements Within a Test Facility

Author

Wright, P, McCormick, D, Kliment, J, Ozanyan, K, Tsekenis, S, Fisher, E, McCann, H, Archilla, V, González-Núñez, A, Johnson, M, Black, J, Lengden, M, Wilson, D, Johnstone, W, Feng, Y, and Nilsson, J

Abstract

We report on the installation and commissioning of two systems for the measurement of cross-sectional distributions of pollutant species in jet exhaust, within the engine ground test facility at INTA, Madrid. These systems use optical tomography techniques to estimate the cross-sectional distributions of CO2 and soot immediately behind the engine. The systems are designed to accommodate the largest civil aviation engines currently in service, without obstruction of the exhaust or bypass flows and with negligible effect upon the entrained flow behavior. We describe the physical construction and installation status of each system. In the case of the CO2 system, we examine the challenges of achieving the structural rigidity necessary for adequate suppression of pointing error within 126 laser-based transmittance measurements, each utilizing a 7 m overall path length. We describe methods developed for efficient implementation of co-planarity and 4-degree-of-freedom alignment of individual paths within this beam array. We also present laboratory performance data for three alternative optical designs that differ in their approach to the management of pointing error and turbulence-induced beam wander and spread. The FLITES soot monitoring capability is based on laser induced incandescence (LII) and uses a short-pulse fiber laser and two CCD cameras, in an autoprojection arrangement. We describe the measurement geometry currently being implemented in the test cell and discuss optical design issues, including once again the effect of the plume itself.

Published
2016

34. ASCLS Annual Meeting 2017: Official Abstracts of Submitted Papers, Case Studies and PostersEffective Incorporation of Performance Standards in Quality Control SystemsSubmandibular ZygomycosisRisk Management and Quality Control in Mass SpectrometryThe Significance of the Laboratory in the Work Up and Monitoring of Seemingly Independent Illnesses That In Fact Were InterrelatedThe Education Gap in Clinical MicrobiologyValidation of an Allelic Discrimination Assay for Drug MetabolismDevelopment of a High Resolution Melt Curve Assay to Detect Sickle Cell DiseasePhytochemical Effects on Bacterial BiofilmField Evaluation of Onsite Monitors for Surface Contamination by 5-fluorouracilComparison of Test Results for IHC, FISH and NGS when Screening for Molecular MarkersSevere Factor VII Deficiency in a NewbornValidation of Vysis LSI ALK and ROS1 Break Apart FISH ProbesA Prospective Study of Patients Diagnosed with Sarcoidosis: Nutrition, Health Assessment and Environmental ExposuresAssessment of Intake of Cinnamon Supplements on Hemoglobin A1c Levels in Pre-DiabeticsNGS Testing Helps to Identify New Treatment Opportunities for Advanced Solid Tumor Cancers Driven by Molecular AlterationsCause and Concern for Patients with B- cell Lymphoproliferative DisordersOral Presentation AbstractsInpatient Utilization of Point of Care Glucose Concomitant TestingWhat is That Bug in My Blood?Effects of Blood Banking Advanced Technology Practice Prior to Clinical Rotations on Clinical Laboratory Science Student OutcomesPlanting Your Lab Garden with Your OWN Seeds: A Novel Approach to the Laboratory Professional Shortage

Author

Agboyi, Selom, primary, Ahrens, Sean, primary, Brooks, Zoe C., primary, Castillo, Demetra, primary, Cordner, Ryan, primary, Dablouk, Hatoon, primary, Maza, Connie R., primary, Heuertz, Rita M., primary, Smith, Jerome, primary, Janssen, Adam, primary, Lumm, Wendy C., primary, Caruana, Louis B., primary, Shokrani, M, primary, Thacker, Audrey, primary, Uko, Anietie, primary, Ezekiel, Uthayashanker R., primary, Gaffney, Anne, primary, Smith, Linda A., primary, Nadder, Teresa S., primary, Rittersbach, Joann, primary, Mehta, Shashi, additional, Josko, Deborah, additional, Kirn, Thomas, additional, Hopkins, John, additional, Sweeney, George, additional, Dunn, Celeste, additional, Davis, Mary F., additional, Hendrix, Ericka, additional, Nwokey, Chanel, additional, Umeh, Yvonne N., additional, Hendrix, Ericka C., additional, Sammons, Deborah, additional, Robertson, Shirley, additional, MacKenzie, Barbara, additional, Snawder, John, additional, Nguyen, Thuy, additional, Block, Miriam, additional, Magharyous, Hany, additional, Christiansen, Jason, additional, Lamoureux, Jennifer, additional, Sloan, Gloria, additional, Jonah, Mary, additional, Savage, Natasha, additional, Kraj, Barbara, additional, Pretlow, Lester, additional, Redwine, Gerald D., additional, Limmer, Sheridan, additional, Rohde, Rodney E., additional, Russian, Christopher, additional, Lukaszuk, J, additional, Walker, DA, additional, McCann, H, additional, McMahon, L, additional, Kim, E, additional, Templer, Jessica, additional, Multani, Pratik, additional, Dallas, Steven, additional, Wilkerson, Cynthia, additional, and Gendron, Mark, additional

Published
2017
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36. Waste Crime: Low Risks - High Profits. Gaps in Meeting the Global Waste Challenge. A Rapid Reponse Assessment

Author

Rucevska, I, Nelleman, C, Isarin, N, Yang, W, Liu, N, Yu, K, Sandnæs, S, Olley, K, McCann, H, Devia, L, Bisschop, Lieselot, Soesilo, D, Schoolmeester, T, Henriksen, R, Nilsen, R, Business Economics, and Criminology

Subjects
SDG 16 - Peace, Justice and Strong Institutions, SDG 12 - Responsible Consumption and Production
Abstract

More than ever, our future depends upon how we manage the future of our waste. As an integrated part of sustainable development, effective waste management can reduce our global footprint. Ignoring or neglecting the challenges of waste, however, can lead to significant health, environmental and economic consequences. A staggering 1.3 billion tonnes of food is produced each year to feed the world’s 7 billion people. Yet, according to the Food and Agriculture Organization (FAO), around US$1 trillion of that food goes to waste. With 200,000 new people added every day, the world can ill afford to waste such a massive amount of food. Global waste, however, does not stop at food. Consumers are increasingly buying products that are wrapped in plastics and paper. Much of this packaging – and eventually the products themselves – will end up in landfills. This trend has both health and environmental consequences, especially given the rapid rise of hazardous waste such as electronics.

Published
2015

39. Is CHCHD10 Pro34Ser pathogenic for frontotemporal dementia and amyotrophic lateral sclerosis?

Author

Dobson-Stone, C, Shaw, AD, Hallupp, M, Bartley, L, McCann, H, Brooks, WS, Loy, CT, Schofield, PR, Mather, KA, Kochan, NA, Sachdev, PS, Halliday, GM, Piguet, O, Hodges, JR, Kwok, JBJ, Dobson-Stone, C, Shaw, AD, Hallupp, M, Bartley, L, McCann, H, Brooks, WS, Loy, CT, Schofield, PR, Mather, KA, Kochan, NA, Sachdev, PS, Halliday, GM, Piguet, O, Hodges, JR, and Kwok, JBJ

Published
2015

40. TDP-43 proteinopathies: Pathological identification of brain regions differentiating clinical phenotypes

Author

Tan, RH, Kril, JJ, Fatima, M, McGeachie, A, McCann, H, Shepherd, C, Forrest, SL, Affleck, A, Kwok, JBJ, Hodges, JR, Kiernan, MC, Halliday, GM, Tan, RH, Kril, JJ, Fatima, M, McGeachie, A, McCann, H, Shepherd, C, Forrest, SL, Affleck, A, Kwok, JBJ, Hodges, JR, Kiernan, MC, and Halliday, GM

Abstract

The pathological sequestration of TAR DNA-binding protein 43 (TDP-43, encoded by TARDBP) into cytoplasmic pathological inclusions characterizes the distinct clinical syndromes of amyotrophic lateral sclerosis and behavioural variant frontotemporal dementia, while also co-occurring in a proportion of patients with Alzheimer's disease, suggesting that the regional concentration of TDP-43 pathology has most relevance to specific clinical phenotypes. This has been reflected in the three different pathological staging schemes for TDP-43 pathology in these different clinical syndromes, with none of these staging schemes including a preclinical phase similar to that which has proven beneficial in other neurodegenerative diseases. To apply each of these three staging schemes for TDP-43 pathology, the clinical phenotype must be known undermining the potential predictive value of the pathological examination. The present study set out to test whether a more unified approach could accurately predict clinical phenotypes based solely on the regional presence and severity of TDP-43 pathology. The selection of brain regions of interest was based on key regions routinely sampled for neuropathological assessment under current consensus criteria that have also been used in the three TDP-43 staging schemes. The severity of TDP-43 pathology in these regions of interest was assessed in four clinicopathological phenotypes: amyotrophic lateral sclerosis (n = 27, 47-78 years, 15 males), behavioural variant frontotemporal dementia (n = 15, 49-82 years, seven males), Alzheimer's disease (n = 26, 51-90 years, 11 males) and cognitively normal elderly individuals (n = 17, 80-103 years, nine males). Our results demonstrate that the presence of TDP-43 in the hypoglossal nucleus discriminates patients with amyotrophic lateral sclerosis with an accuracy of 98%. The severity of TDP-43 deposited in the anterior cingulate cortex identifies patients with behavioural variant frontotemporal dementia with

Published
2015

42. Optimising laser absorption tomography beam arrays for imaging chemical species in gas turbine engine exhaust plumes

Author

McCormick D., Twynstra M.G., Daun K.J., McCann H.

Subjects
array design, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, gas turbine engines, image reconstruction, chemical species, absorption tomography
Abstract

This paper will describe the application of resolution matrices to the design of an optimised 126 beam, 6m absorption tomography array for imaging concentrations of CO2 in the exhaust plume of a Rolls-Royce Trent 1000 gas turbine engine. The resolution matrix will be used to define a fitness value, which is a function the beam configuration, and is minimised by the optimal beam arrangement. Constraints ensure that the optimised beam arrangement can be implemented in a real tomography system. Genetic algorithms are used to determine the optimal array design from the large problem set. Results for image reconstructions of a quasi-realistic phantom of the exhaust plume for each of the array designs are presented with indications of the reconstruction errors. From the results, conclusions are drawn on the suitability of applying resolution matrices to the design of beam arrays for real limited-data tomographic systems.

Published
2013

43. TIPOD - A user-friendly software base for chemical species tomography systems

Author

Terzija N., Tsekenis A., McCormick D., McCann H.

Subjects
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, TIPOD, process tomography, data processing, user-friendly interface
Abstract

The user-friendly MATLAB-based TIPOD package provides fast, flexible analysis and image reconstruction of large volumes of chemical species tomography data. Initially focused on in-cylinder automotive applications, its scope has been extended and its design modified to permit easier modification and customization. The new version, TIPOD-2013, provides options for: data pre-processing (e.g. filtering, denoising); data referencing; quality-based data selection; image reconstruction (e.g. Landweber with median or wavelet filters, Tikhonov); off-line still-frame display; export to industry-standard video; and flexible simulation for development or validation of optimal sensor arrays. The key features of TIPOD-2013 are described, along with examples of its use.

Published
2013

44. The Evolution of Host Specificity and Virulence in the Plant Pathogen Pseudomonas syringae

Author

McCann, H.

Abstract

The Pseudomonas syringae species complex comprises dozens of plant pathogenic strains with highly specific interactions with diverse host species and cultivars. My thesis research examines multiple stages of P. syringae’s coevolutionary interactions, from the earliest events involved in specialization to a novel host through to an assessment of the origin and evolution of the latest pandemic of this destructive infectious disease on Actinidia (kiwifruit) spp. The serial passaging of a strain of P. syringae on a novel host resulted in the appearance of an evolved line exhibiting higher growth on the novel host than the ancestor. The earliest steps towards host specialization were mutations in genes implicated in motility, exopolysaccharide production, and biofilm formation. The growth of this evolved line was compromised on its original host, suggesting there is a cost to specialization. The role of pathoadaptive variation as both a determinant of host specificity and the outcome of an arms race dynamic between P. syringae and its plant hosts was then investigated in order to develop a predictive method for the identification of novel innate immunity triggers. Plant hosts are more likely to evolve recognition to ‘core’ pathogen proteins under negative selection for the maintenance of essential functions, while repeated exposure to host defenses imposes strong selective pressure for elicitor diversification to avoid host recognition. Selected candidate elicitors were identified by screening a selection of plant pathogen genomes for these contrasting signatures of selection. Candidates were validated by testing their induction of Arabidopsis thaliana innate immunity. I conclude my thesis with an investigation into the origin and evolution of a recently emerged pandemic strain of P. syringae pv. actinidiae (Pan). Comparative genomic analyses of over 20 newly sequenced Pan strains revealed the outbreak strains form a distinct clade separate from Asian and Italian strains isolated prior to 2008. Outbreak-specific genes are frequently clustered together or with type 3 secreted effectors in mobile elements. Some outbreak-specific genes appear to have been acquired from vascular and woody pathogens, representing genes potentially involved in Pan’s ability to infect and spread through the woody tissues and vasculature of the kiwifruit vine.

Published
2013

46. National scientific medical meeting 1995 abstracts

Author

Norris, S., Collins, C., Hegarty, J., O’Farrelly, C., Carton, J., Madrigal, L., O’Donoghue, D. P., Holloway, H., Fielding, J. F., Mullins, W., Hone, S. W., Donnelly, M., Powell, F., Blayney, A. W., Cahill, E. A., Daly, S. F., Turner, M. J., Sullivan, P. A., McLoughlin, M., Skelly, M. M., Mulcahy, H. E., Connell, T., Duggan, C., Duffy, M. J., Troy, A., Sheahan, K., Whelan, A., Herra, C. M., Keane, C. T., Johnson, H., Lee, B., Doherty, E., McDonnell, T., Mulherin, D., FitzGerald, O., Bresnihan, B., Hassett, H. M., Boyce, A., Greig, V., O’Herlihy, C., Smyth, P. P. A., Roche, E. F., McCormack, I., Tempany, E., Cullen, M. J., Smith, D. F., McBrinn, Y., Murray, B., Freaney, R., Keating, D., McKenna, M. J., O’Hare, J. A., Alam, H., Raza, Q., Geoghegan, M., Killalea, S., Hall, M., Feely, J., Kyne, L., O’Hara, B., Cullen, M., Rea, I. M., Donnelly, J. P., Stout, R. W., Lacey, P., Donnelly, M. J., McGrath, J., Hennessy, T. P., Timon, C. V. I., Hyde, D., Xia, H. X., Buckley, M., O’Morain, C., Keating, S., Xia, H., McGrath, J. P., Stuart, R. C., Lawlor, P., Byrne, P. J., Walsh, T. N., Hennessy, T. P. J., Duffy, M., Tubridy, M., Redmond, J., Monahan, K., Murphy, R. P., Headon, D. R., O’Gorman, T., O’Reilly, F. M., Darby, C., Murphy, G. M., Murphy, A., Codd, M., Dervan, P., Lawlor, D., Loughlin, S. O., Flanagan, N., Watson, R., Barnes, L., Kilgallen, C., Sweeney, E., Mynes, A., Mooney, D., Donoghue, I., Browne, O., Kirrane, J. A., McKenna, D., Young, M., O’Toole, E., O’Briain, S., Srinivasan, U., Feighery, C., Leonard, N., Jones, E., Moloney, M. A., Weir, D. G., Lawler, M., O’Neill, A., Gowing, H., Pamphilon, D., McCann, S. R., O’Toole, G., Orren, A., Seifer, C. M., Crowley, D. C., Sheehan, G. J., Deignan, T., Kelly, J., Tormey, V. J., Faul, J., Leonard, C., Burke, C. M., Poulter, L. W., Lynch, S., McEntee, G., Traynor, O., Barry, E., Costello, P., Keavney, A., Willoughby, R., O’Donnell, C., Cahill, M., Earley, A., Eustace, P., Osborne, R., Saidlear, C., Holmes, B., Early, A., Moran, A. P., Neisser, A., Polt, R. J., Bernheimer, H., Kainz, M., Schwerer, B., Gallagher, L., Firth, R., Kennedy, N., McGilloway, E., Tubridy, N., Shields, K., Cullen, W. K., Rowan, M. J., Moore, A. R., Rowan, M., Coakley, D., Lawlor, B., Swanwick, G., Al-Naeemi, R., Murphy, R., Codd, N. M., Goggins, M., Kennedy, N. P., Mallon, B. L., Mulcahy, H., Skelly, M., Donoghue, D. O., McCarthy, D., Saunders, A., Veale, D. J., Belch, J. J. F., Breathnach, D., Murphy, E., Kernohan, G., Gibson, K., Wilson, A. G., Duff, G. W., de Vries, N., van de Putte, L. B. A., Donoghue, J., O’Kelly, F., Johnson, Z., Maher, T., Moran, A., Keane, C., O’Neill, D., Horgan, N., Barragry, J. M., Campbell, D. M., Behan, M., O’Connell, P. R., Donnelly, V. S., Crowley, D., Geary, M., Boylan, P., Fanagan, M., Hickey, K., Teoh, T., Doyle, M., Harrison, R., Lyons, D., Shenouda, Y., Coughlan, M., McKenna, P., Lenehan, P., Foley, M., Kelehan, P., Ravichandran, P., Kelly, M., Conroy, A., Fitzpatrick, C., Egan, D., Regan, C. L., McAdam, B. V., McParland, P., FitzGerald, G. A., Fitzgerald, D. J., Sharma, S. C., Foran, K., Barry-Kinsella, C., Harrison, R. F., Gillespie, F. J., O’Mahony, P., Boyle, M., White, M. J., Donohoe, F., Birrane, Y., Naughton, M., Fitzsimons, R. B., Piracha, M., McConkey, S., Griffin, E., Hayes, E., Clarke, T., Parfrey, N., Butler, K., Malone, A. J., Kearney, P. J., Duggan, P. F., Lane, A., Keville, R., Turner, M., Barry, S., Sloan, D., Gallagher, S., Darby, M., Galligan, P., Stack, J., Walsh, N., O’Sullivan, M., Fitzgerald, M., Meagher, D., Browne, S., Larkin, C., Casey, P., O’Callaghan, E., Rooney, S., Walsh, E., Morris, M., Burke, T., Roe, M., Maher, C., Wrigley, M., Gill, M., Burgess, M., Corcoran, E., Walsh, D., Gilmer, B., Hayes, C. B., Thornton, L., Fogarty, J., Lyons, R., O’Connor, M., Delaney, V., Buckley, K., Lillis, D., Delany, V., Hayes, C., Dack, P., Igoe, D., O’Neill, H. J., Kelly, P., McKeown, D., Clancy, L., Varghese, G., Hennessy, S., Gilmartin, J. J., Birthistle, K., Carrington, D., Maguire, H., Atkinson, P., Foley-Nolan, C., Lynch, M., Cryan, B., Whyte, D., Conlon, C., Kucinskas, V., Usinskiene, U., Sakalyte, I., Dawson, E., Molloy, K., Goulden, N., Doyle, J., Lawlor, E., Harrington, M. G., El-Nageh, N., Nolan, M. -L., O’Riordan, J., Judge, G., Crotty, G., Finch, T., Borton, M., Barnes, T., Gilligan, O., Lee, G., Limmer, R., Madden, M., Bergin, C., O’Leary, A., Mulcahy, F., Wallis, F., Glennon, M., Cormican, M., NiRiain, U., Heiginbothom, M., Gannon, F., Smith, T., O’Sullivan, C., Hone, R., Caugant, D. A., Fijen, C. A. P., Van Schalkwyk, E. J., Coetzee, G. J., Riain, U. Ni, Cormican, M. G., Park, L., Flynn, J., Regazzoli, V., Hayes, M., Nicholson, G., Higgins, P., Flynn, N., Corbett-Feeney, G., Conway, D. J., O’Higgins, N. J., Rajendiran, S., Byrne, J., Kilfeather, E., Dingle, P., Hunter, M., Al-Ghazal, S. K., Stanley, P., Palmer, J., Hong, A., Saxby, P., Sheehan, D., Regan, I., O’Mullane, J., Chaoimh, M. Ni, Leahy, M., Heffron, J. J., Lehane, M., Keohane, C., O’Leary, N., Sheehan, M., Renny-Walsh, E., Whelton, M. J., Doyle, C. T., Webster, J., Benjamin, N., FitzGerald, S., Chadha, J. S., FitzGerald, M. G., FitzGerald, G. R., Hemeryck, L., McGettigan, P., Golden, J., Arthur, N., Wen, S. Y., Deegan, P., Cooke, T., Adebayo, G. I., Gaffney, P., Sinnot, M., O’Riordan, D., Hayes, T., O’Connor, C. M., FitzGerald, M. X., Costello, C., Finlay, G., Hayes, J., O’Connor, C., McMahon, K., Hone, S., Robertson, J., Coakley, R., O’Neill, S., Walsh, M., McCarthy, J., Lannon, D., Wood, A. E., Sharkey, R., Mulloy, E., Long, M., Kilgallen, I., Tormey, V., Horne, S., Feeney, T., Muiré, Ó. Ó, Griffin, M. J., Hughes, D., Knaggs, A., Magee, D., McCrory, C., March, B., Phelan, D., White, M., Fabry, J., Buggy, D., Cooney, C., Aziz, E., O’Keefe, D., McShane, A. J., Boylan, J., Tobin, E., Motherway, C., Colreavy, F., Denish, N., Dwyer, R., Bergin, A., O’Brien, K., MacSullivan, R., Carson, K. D., Blunnie, W. P., Moriarty, D. C., Kinirons, B., Lyons, B., Cregg, N., Casey, W., Moore, K. P., Colbert, S. A., Ecoffey, C., O’Gorman, D., Fitzgerald, J., Diamond, P., Codd, M. B., Sugrue, D. D., Kellett, J., Tighe, M., McKenna, C. J., Galvin, J., McCann, H. A., Scallon, A., Fraser, A., Norton, M., Tomkin, G., Graham, I., Byrne, A., Maher, M., Moran, N., Fitzgerald, D., O’Callaghan, D., Coyle, D., Nugent, A. G., McGurk, C., Johnston, G. D., Nugent, A., Silke, B., Murphy, N., Jennings, L., Pratico, D., Doyle, C., Hennessy, T., McCann, H., Sugrue, D., Donnelly, S., Hennessy, A., Hartigan, C., MacDonald, D., Blake, S., McDonald, D., Dominque, D., McMechan, S. R., MacKenzie, G., Allen, J., Wright, G. T., Dempsey, G. J., Crawley, M., Anderson, J., Adgey, A. A. J., Harbinson, M. T., Campbell, N. P. S., Wilson, C. M., Ellis, P. K., McIlrath, E. M., McShane, A., Keaveny, T. V., Rabenstein, K., Scheller, F., Pfeiffer, D., Urban, C., Moser, I., Jobst, G., Manz, A., Verpoorte, S., Dempsey, F., Diamond, D., Smyth, M., Dempsey, E., Hamilton, V., Twomey, J., Crowley, R., Fenelon, L., Walsh, F., McCann, J., McDonagh, P., McGovern, E., Luke, D., Crowley, K., Mannion, D., Murphy, D., Clarkson, K., Carton, E., Leonard, I., O’Toole, D., Staunton, M., Griffin, M., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Herity, N. A., Allen, J. D., O’Moore, R., Crotty, G. M., DeArce, M., Nikookam, K., Keenan, P., Cregan, D., O’Meara, N., Forman, S., Cusack, D. A., and Farrell, B.

Subjects
Irish Journal, Acquire Immune Deficiency Syndrome, Graft Versus Host Disease, Coeliac Disease, Methicillin Resistant Staphylococcus Aureus, Article
Published
1995

48. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction

Author

Van de Werf, F., Armstrong, P. W., Granger, C., Wallentin, L., Adgey, A. A. J., Aylward, P., Binbrek, A. S., Califf, R., Cassim, S., Diaz, R., Fanebust, R., Fioretti, P. M., Huber, K., Husted, S., Lindahl, B., Lopez-Sendon, J. L., Makijarvi, M., Meyer, J., Navarro Robles, J., Pfisterer, M., Seabra-Gomes, R., Soares-Piegas, L., Sugrue, D., Tendera, M., Theroux, P., Toutouzas, P., Vahanian, A., Verheugt, F., Sarelin, H., Goetz, G., Bluhmki, E., Daclin, V., Danays, T., Houbracken, K., Kaye, J., Reilly, P., Hacke, W., von Kummer, R., Lesaffre, E., Bogaerts, K., Peeters, C., Fox, K. A. A., Brower, R., Hirsh, J., Maggioni, A., Tijssen, J., Weaver, D., Beernaert, A., Beysen, N., Broos, K., De Prins, E., D'Hollander, K., Dupon, L., Fomyna, N., Fransen, A., Genesse, D., Goffin, L., Hendrickx, R., Jansen, B., Jorissen, F., Luys, C., Luyten, A., Marschal, C., Moreira, M., Munsters, K., Salerno, R., Schoovaerts, C., Sinnaeve, P., Schildermans, C., Vandenberghe, K., Vandeschoot, K., Van Gucht, H., Van Rompaey, P., Vlassak, S., Watzeels, M., Wittockx, H., Galan, K., Humeniuk, L., Seidel, A., Molina, M., Hafley, G., Alexander, J., Pascual, A., Bestilny, S., Temple, T., Ahuad Guerrero, R., Albisu, J. P., Bassani Arrieta, C. A., Bono, J., Caccavo, A., Cagnolatti, A., Cartasegna, L. R., Castellanos, R., Chekerdemian, S., Covelli, G., Cuello, J. L., Cuneo, C. A., Fernandez, A., Ferrara, C., Ferro-Queirel, E., Gambarte, A., Garcia-Duran, R., Hasbani, E., Hrabar, A., Keller, L., Lobo Marquez, L. L., Luciardi, H., Macin, S. M., Marinig, A., Marzetti, E., Muntaner, J., Nordaby, R., Orlandini, A. D., Piombo, A. C., Pomposiello, J. C., Quijano, R. A., Amerena, J., Aroney, G., Buckmaster, N., Carroll, P., Fitzpatrick, M., Newman, R., Rowe, M., Singh, B., Thomson, A., Winter, C., Eber, B., Gaul, G. B., Klein, W., Leisch, F., Mayr, H., Mlczoch, J., Niessner, H., Pachinger, O., Pall, H., Pichler, M., Roggla, G., Schaflinger, E., Schreiber, W., Slany, J., Traindl, O., Zenker, G., Beckers, J., Bekaert, I., Berthe, C., Bodur, G., Carlier, B., Carlier, M., Carpentier, J., Celen, H., Charlier, F., Clement, A., Coenen, A., Crochelet, L., De Keyser, F., De Man, F., de Meester, A., Dendale, P., Dhondt, E., Dhooghe, G., El Allaf, D., Elshot, S., Emmerechts, C., Foret, F., Gatera, E., Geraedts, J., Gerardy, A. C., Gysbrechts, M., Hallemans, R., Hellemans, S., Herssens, H., Huygens, L., Janssens, L., Lalmand, J., Maamar, R., Marechal, P., Mertens, D., Michel, P., Morandini, E., Nannan, M., Nguyen, D., Odeurs, W., Peerenboom, P., Pirenne, B., Quinonez, M., Raymenants, E., Renard, M., Silance, P. G., Standaert, A. M., Striekwold, H., Thiels, H., Valadi, D., van Brabandt, H., Van Dormael, M., Van Iseghem, P., Van Walleghem, U., Vanden Bosch, H., Vandenbossche, J. L., Vermylen, J., Verstraete, S., Vo Ngoc, P., Willems, P., Zenner, R., Campos de Albuquerque, D., Coutinho, M., de Camargo Carvalho, A. C., Fernandes Manenti, E. R., Ferreira Azevedo, A., Golin, V., Gun, C., Marin Neto, J. A., Marino, R. L., Miranda Abrantes, J. A., Nicolau, J. C., Porto Alegre Dancini, E. M., Rabelo, A., Ramos, R. F., Rizzi Coelho, O., Alexander, D., Bata, I. R., Bhargava, R. K., Bogaty, P., D'Amours, G., Darcel, I., Finnie, K. J. C., Fowlis, R., Gupta, M. K., Henderson, M., Howlett, M. K., Javier, J. J., Kieu, C. V., Kumar, G., Lebouthillier, P., Leduc, F., Lepage, S., Mcavinue, T., Mcgillen, J. E., Mcmeekin, J. D., Morse, J. W., Pistawka, K., Raimondo, E. F., Sandrin, F., Smith, H., Smylie, P. C., Tran, K., Turabian, M., Wagner, K. R., Winkler, L. H., Woo, K. S., Falstie-Jensen, N., Lind Rasmussen, S., Lomholt, P., Markenvard, J., Nielsen, H., Petersen, J., Romer, F., Ahonen, J., Huttunen, M., Kokkonen, L., Luukkonen, J., Mantyla, P., Melin, J., Mustonen, J., Valli, J., Voutilainen, S., Agraou, B., Allam, S., Baradat, G., Battistella, P., Bazin, P., Bouvier, J. -M., Destrac, S., Fouche, R., Fournier, P. -Y., Funck, F., Garnier, H., Grall, J. -Y., Gully, C., Lallement, P. -Y., Loiselet, P., Mycinsky, C., Page, A., Parisot, M., Range, G., Rocher, R., Tafani, C., Thisse, J. -Y., Tibi, T., Tissot, M., Wahl, P., Backenkohler, U., Bavastro, P., Beckmann-Hiss, H., Behnke, M., Bermes, M., Bernsmeier, R., Bethge, K. P., Bethge, H., Block, M., Burkhardt, W., Cieslinski, G., Claus, G., Deetjen, A., Diefenbach, A., Diehm, C., Dietz, A., Dippold, W. G., Eichner, A., Erckenbrecht, J. F., Gawlick, L., Gerber, V., Goppel, L., Gottwik, M., Grosch, B., Hammer, B., Hanheide, M., Hanrath, P., Haspel, J., Hennersdorf, F., Hermanns, M., Hoffmeister, H. M., Holzapfel, P., Hubner, H., Jansen, W., Jung, S., Kaddatz, J., Kienbock, H., Klein, H. H., Konz, K. H., Kulschbach, M., Leschke, M., Liebau, G., Linnartz, M., Lockert, G., Loesbrock, R., Lollgen, H., Ludwig, N., Mudra, H., Munzer, K., Nebel, B., Nellessen, U., Neu, C., Olbrich, H. G., Pfeffer, A., Pfeiffer, P., Plate, V., Pollock, B., Rapp, H., Rommele, U., Sauer, K., Scheffler, N., Schlotterbeck, K., Schmidt-Salzmann, A., Schnitzler, G., Schumann, H., Schuster, C. J., Schuster, P., Schweizer, P., Seitz, K., Simon, R., Spes, C., Szabo, S., Terhardt-Kasten, E., Theuerkauf, B., Tigges, R., Tinnappel, J., Topp, H., Trockel, P., Unland, N., Veth, V., Vom Dahl, J., Vossbeck, G., Weindel, K., Weib, D., Wiewel, D., Wirtz, P., Zipp, C., Apostolou, T., Chalkidis, C., Exadaktylos, N., Foussas, S., Hatseras, D., Karas, S., Karydis, K., Lambrou, S., Louridas, G., Manolis, A., Nanas, J., Novas, I., Panagiotidou, T., Papadopoulos, C., Papakonstantinou, D., Papasteriadis, E., Pavlidis, P., Pyrgakis, V., Skoufas, P., Stavrati, A., Tyrologos, A., Vardas, P., Vrouchos, G., Zacharoulis, A., Zarifis, J., Brown, A., Daly, K., Fennell, W., Horgan, J., Mccann, H., Mcdonald, K., O'Reilly, M., Sullivan, P., Altamura, G., Ambrosio, G., Auteri, A., Aveta, P., Azzarito, M., Badano, L. P., Barbiero, M., Barletta, C., Biscosi, C., Boccanelli, A., Bottero, M., Brizio, E., Brunazzi, M. C., Brunelli, C., Bugatti, U., Capozi, A., Capucci, A., Carfora, A., Caronna, A., Carrone, M., Casazza, F., Cauticci, A., Ceci, V., Ciconte, V., Circo, A., Ciricugno, S., Comito, F., Cornacchia, D., Corsini, G., D'Andrea, F., De Rosa, P., De Simone, M., Del Citerna, F., Del Pinto, M., Dell'Ali, C., Della Casa, S., Della Monica, R., Delogu, G., Di Biase, M., Di Chiara, A., Di Guardo, G., Di Marco, S., Di Mario, F., Di Napoli, T., Di Palma, F., Fadin, B. M., Fazzari, M., Ferraiuolo, G., Fiaschetti, R., Fontanelli, A., Fresco, C., Gambelli, G., Gasbarri, F., Gemelli, M., Giani, P., Gigantino, A., Giomi, A., Giorgi, G., Greco, C., Gregorio, G., Guagnozzi, G., Guiducci, U., Guzzardi, G., Izzo, A., La Rosa, A., Leone, F., Leone, G., Lo Bianco, F., Locuratolo, N., Maggiolini, S., Malinconico, M., Mancone, C., Mangiameli, S., Marchi, S. M., Maresta, A., Mauri, F., Mazzini, C. A., Michisanti, M., Miracapillo, G., Modena, M. G., Morgagni, G. L., Mossuti, E., Nascimbeni, F., Negrelli, M., Notaristefano, A., Pardi, S., Peci, P., Pettinati, G., Pietropaolo, F., Pirelli, S., Pretolani, M., Prinzi, D., Proietti, F., Raganelli, L., Rapino, S., Re, F., Ricci, R., Rinaldi, G., Rusticali, G., Severi, S., Spallarossa, P., Tartagni, F., Terrosu, P., Tortorella, G., Tota, F., Tritto, I., Tuccilo, B., Turco, V., Uscio, G., Valagussa, F., Vergoni, W., Verzuri, M. S., Vetrano, A., Villani, R., Zanini, R., Boisante, L., Niclou, R., Alcocer, L., Castro, A., Fragoso, J., Gonzalez, V., Gonzalez-Pacheco, H., Hernandez-Santamaria, I., Huerta, R., Huerta, D., Martinez, A., Mendoza, M., Moguel, R., Navarro, J., Portos, J. M., Rodriguez, I., Sierra, L., Valencia, S., Vazquez, A., Arnold, A. E. R., Boehmer, A. G., de Graaf, J. J., Funke Kupper, A. J., Gobel, E. J. A. M., Janus, C. L., Linssen, G. C. M., Sedney, M. I., Slegers, L. C., Spierenburg, H. A. M., Strikwerda, S., Tans, J. G. M., Twisk, S. P. M., van der Heijden, R., van Kalmthout, P. M., Verheugt, F. W. A., Holt, E., Skogsholm, A., Thorshaug, R., Thybo, N. K., Wang, H., Maciejewicz, J., Piotrowski, W., Pluta, W., Ruminski, W., Skura, M., Smielak-Korombel, W., Carranca, J., Carvalho, M., Catarino, C., Cunha, D., Ferreira, D., Ferreira, J., Ferreira da Costa, A. F., Lopes de Carvalho, J., Martins, L., Mourao, L., Oliveira Carrageta, M., Prazeres de Sa, E., Puig, J., Ramalho Dos Santos, M. J. J., Resende, M., Seabra Gomes, R., Baig, M. M. E., Bayat, J., Benjamin, J. D., Ranjith, N., Routier, R., Wittmer, H., Abizanda Campos, R., Alonso Garcia, M. A., Amaro Cendon, A., Arboleda Sanchez, J. A., Blanco Varela, J., Bruguera I Cortada, J., Carpintero Avellaneda, J. L., Caturla Such, J., Civeira Murillo, E., Fernandez Aviles, F., Fernandez Fernandez, R., Figueras Bellot, J., Fiol Sala, M., Froufe Sanchez, J., Garcia Calabozo, R., Garcia Palacios, J. L., Gonzalez Maqueda, I., Kallmeyer Martin, C., Lopez Sendon, J. L., Manzano Ramirez, A., Marine Rebull, J., Monton Rodriguez, A., Pique Gilart, M., Reina Toral, A., Rodriguez Llorian, A., Ruano Marco, M., Sanchez Miralles, A., Sanjose Garagarza, J. M., Santalo Bel, M., Torres Ruiz, J. M., Valentin Segura, V., Ahlstrom, P., Ahremark, U., Bandh, S., Bellinetto, A., Dahlberg, A., Hansen, O., Hurtig, U., Jonasson, L., Karlsson, J. E., Larsson, L. E., Moller, B., Ohlin, H., Persson, H., Sandstedt, L., Soderberg, S., Svennberg, L., Swahn, E., Tygesen, H., Broccard, A. F., Estlinbaum, W., Follath, F., Frutiger, A., Hess, N., Maggiorini, M., Marti, D., Muller, P., Rickenbacher, P., Schaller, M. D., Weinbacher, M., Abdulali, S., Ahmad, G., George, S., Ghazi, A., Rao, K. N., Bishop, A., Bridges, A., Canepa-Anson, R., Cave, M., Clarck, R., Cooper, I., de Belder, A., Farrer, M., Kendall, J. M., Ludman, P., Mattu, R., Mcglinchey, P., Moriarty, A. J., Muthusamy, S., Nee, P. A., Nolan, J., Papouchado, M., Rose, E. L., Shahi, M., Stephens, J., Trevelyan, J., Abdul-Karim, A., Adler, L., Arunasalam, S., Avington, D., Baron, S., Beel, T., Bellamy, B., Bennett, J., Berndt, T., Berrick, A., Bersin, R. M., Bethala, V., Bharath, S., Bouchard, A., Boulet, J. E., Bowerman, R., Boyek, T., Brar, R. S., Brodell, G., Bryant, B., Buckner, J. K., Cage, J., Cannon, J. D., Carducci, B., Carr, K., Chang, M., Chelliah, N., Chin, W. L., Chin, J., Church, D. H., Clark, R., Coulis, L., Dadkhah, S., Dearing, B., Defranco, A., Dharawat, M., Dharawat, R., Dhruva, N., Dicola, J., Dykstra, G., Eisenberg, S., El-Bialy, A., Fera, S., Ford, K., Foreman, R. D., Friedman, S., Friedman, V., Garibian, G., Gelormini, J., Geninatti, M. R., Genovese, R., Ghazi, F., Gilchrist, I., Gitler, B., Glover, R., Gonzalez, J., Goulah, R., Graham, B., Gray, R., Grodman, R., Habib, G. B., Hack, T., Hamroff, G., Hanna, G., Hart, M., Haught, H., Hawkins, J., Hempel, R., Hiremath, Y., Hiser, W., Holland, E., Jaffe, N., Jamal, N., James, K. F., Kalla, S., Kates, M., Kemper, A. J., Kennedy, J. J., Kerut, E. K., Killpack, M., King, J., T. Y., Ko, Kollar, K., Kontos, M., Kugelmassluu, A., Kumar, A., Kutscher, A. H., Lambrecht, C., Lancaster, L., Layden, J., Lazar, A., Lebow, M., Lee, C., Lee, A. B., Lehr, J., Levin, F. L., Levitt, R., Levy, R. M., Lieberman, A., Litman, G. I., Lui, H., Luu, M. Q., Macdonald, G., Madyoon, H., Mancherje, C., Marmulstein, M., Mclaurin, B. T., Mcnellis, M., Mendelson, R., Micale, P. J., Miller, M. J., Miller, M. S., Miller, J., Millman, A., Millsaps, R., Minor, S., Modica, J., Morse, H., Moskovits, N., Nester, B. A., Newton, A. S., Niazi, I., Niederman, A., Oatfield, R., Painter, J. A., Pamfilis, S. M., Pamulapati, K. M., Patel, N., Payne, R., Pearson, C., Peizner, D. S., Petrovich, L., Piriz, J., Pollack, M., Pollock, S., Popkave, A., Puma, J. A., Quesada, R., Quigley-Malcolm, D., Raby, K., Ravindran, K., Rees, A. P., Reiner, J., Rivera, E., Rogers, F., Rosenthal, A., Rowe, W. W., Ryan, P. F., Ryman, K., Salacata, A., Santolin, C., Saucedo, J., Savage, R., Savage, W., Schumacher, R., Segarra, S., Sharkey, S., Shonkoff, D., Silver, M., Silver, S. L., Singh, G., Sinyard, R. D., Sporn, D., Srivastava, N. K., Stomel, R., Suresh, D. P., Tallman, M., Togioka, T., Varma, S., Verant, R. P., Wallach, R., Weinberg, M., Weinberg, D., Weinstein, J. M., Wesley, G., Westerman, J. H., Wheeling, J., Whitaker, J., Widmer, M., Yasin, M., and Zakrzewski, M. J.

Subjects
Male, medicine.medical_specialty, Abciximab, Ischemia, Myocardial Infarction, Tenecteplase, Injections, Immunoglobulin Fab Fragments, Reperfusion therapy, Fibrinolytic Agents, Recurrence, Internal medicine, medicine, Humans, Myocardial infarction, Enoxaparin, Aged, Intention-to-treat analysis, Chi-Square Distribution, business.industry, Heparin, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Survival Analysis, Regimen, Treatment Outcome, Anesthesia, Tissue Plasminogen Activator, Cardiology, Drug Therapy, Combination, Female, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

BACKGROUND: Current fibrinolytic therapies fail to achieve optimum reperfusion in many patients. Low-molecular-weight heparins and platelet glycoprotein IIb/IIIa inhibitors have shown the potential to improve pharmacological reperfusion therapy. We did a randomised, open-label trial to compare the efficacy and safety of tenecteplase plus enoxaparin or abciximab, with that of tenecteplase plus weight-adjusted unfractionated heparin in patients with acute myocardial infarction. METHODS: 6095 patients with acute myocardial infarction of less than 6 h were randomly assigned one of three regimens: full-dose tenecteplase and enoxaparin for a maximum of 7 days (enoxaparin group; n=2040), half-dose tenecteplase with weight-adjusted low-dose unfractionated heparin and a 12-h infusion of abciximab (abciximab group; n=2017), or full-dose tenecteplase with weight-adjusted unfractionated heparin for 48 h (unfractionated heparin group; n=2038). The primary endpoints were the composites of 30-day mortality, in-hospital reinfarction, or in-hospital refractory ischaemia (efficacy endpoint), and the above endpoint plus in-hospital intracranial haemorrhage or in-hospital major bleeding complications (efficacy plus safety endpoint). Analysis was by intention to treat. FINDINGS: There were significantly fewer efficacy endpoints in the enoxaparin and abciximab groups than in the unfractionated heparin group: 233/2037 (11.4%) versus 315/2038 (15.4%; relative risk 0.74 [95% CI 0.63-0.87], p=0.0002) for enoxaparin, and 223/2017 (11.1%) versus 315/2038 (15.4%; 0.72 [0.61-0.84], p

Published
2001

49. Reduced costs with bisoprolol treatment for heart failure - An economic analysis of the second Cardiac Insufficiency Bisoprolol Study (CIBIS-II)

Author

Bacquet, P, Levy, E, Mcguire, A, Mcmurray, J, Merot, Jl, Paschen, B, Remme, Wj, Szucs, Td, Klein, W, Brunhuber, W, Hofmann, R, Kuhn, P, Nesser, Hj, Slany, J, Weihs, W, Wiedermann, C, Wimmer, H, van Mieghem, W, Boland, J, Chaudron, Jm, Jordaens, L, Melchior, Jp, Aschermann, M, Bruthansl, J, Hradec, M, Kolbel, F, Semrad, B, Haghfelt, T, Hansen, Jf, Goetzsche, Co, Hildebrandt, P, Kassis, E, Rasmussen, V, Rokkedal, J, Thomassen, A, Groundstroem, K, Uusimaa, P, Le Heuzey JY, Aumont, Mc, Aupetit, Jf, Baille, N, Baudouy, P, Belin, A, Bonneau, A, Bonneric, G, Bousser, Jp, Citron, B, Dary, P, Decoulx, E, De Groote, P, Denolle, T, Dievart, F, Duriez, P, Eicher, Jc, Enjuto, G, Ferriere, M, Fournier, E, Garandeau, M, Gauthier, J, Genest, M, Gerbe, A, Godenir, Jp, Guillot, B, Guillot, Jp, Guillot, P, Heno, P, D'Ivernois, C, Jean, M, Kacet, S, Kalle, R, Komajda, M, Lacroix, A, Lallemand, R, Lardoux, H, Marquet, M, Martin, M, Martin, O, Mery, D, Mossaz, R, Mothes, P, Olive, T, Ostorero, M, Paganelli, F, Page, E, Pauly Laubry, C, Puel, J, Rousseau, Jf, Roux, Jj, Schenowitz, A, Sourdais, K, Tremel, F, Verdun, A, Witchiz, S, Wolf, Je, Hombach, V, Assmann, I, Beyer, T, Bischoff, Ko, Darius, H, Ertl, G, Fleck, E, Forster, K, Freytag, F, Gleichmann, U, Haasis, R, Henssge, R, Hey, D, Hesse, P, Hofs, T, Keck, M, Klein, H, Kromer, Et, Kruls Munch, J, Luderitz, B, Maisch, B, Mitrovic, V, Neubauer, S, Osterziel, Kj, Simon, H, Spitzer, Sg, Stohring, R, Taubert, G, Teichmann, W, Theisen, K, Wende, W, Wieser, H, Zotz, R, Bridges, A, Adgey, J, Ambepitiya, G, Boon, N, Boyle, Rm, Cowley, Aj, Cripps, T, Davies, Mk, Dunn, F, Findlay, J, Forsey, P, Fyfe, T, Gould, B, Greenwood, Tw, Hubner, P, Khan, S, Lewis, P, Mackay, A, Maltz, M, Mcarthur, J, Mcleod, A, Mcleod, D, Metcalfe, M, Millar Craig, M, Mills, P, Nelson, Jk, Nicholls, D, Oakley, Gd, Patterson, Dlh, Pohl, Jef, Ray, S, Silke, B, Wilkinson, Pr, Preda, I, Csanady, M, Cserhalmi, L, Edes, I, Gesztesi, T, Karpati, P, Simon, K, Tarjan, J, Fogari, R, Tramarin, R, Galie, N, Giani, P, Milanese, U, Scalvini, S, Scrutinio, D, Sechi, Leonardo Alberto, Tettamanti, F, De Vito, F, Crean, P, Mccann, H, Mulcahy, D, Sugrue, D, van Hoogenhuyze DCA, van der Burgh PH, Ciampricotti, R, van Dantzig JM, Denhartog, Fr, Henneman, Ja, van Kesteren HAM, Kragten, Ja, Liem, Kl, Limburg, A, van der Linde MR, Linssen, Gcm, Pasteuning, H, Penn, Hjam, Van Rossum, P, Schaafsma, Hj, Schelling, A, Sloos, R, Wesdorp, Jcl, Korewicki, J, Achremczyk, P, Czestockowska, E, Dowgird, M, Dyduszynski, A, Gorski, J, Ilmurzynska, K, Janicki, K, Kornacewicz Jach, Z, Kraska, T, Krzeminska Pakula, M, Kuch, J, Nartowicz, E, Petelenz, T, Piwowarska, W, Rawczynska Englert, I, Ruzyllo, W, Swiatecka, G, Tendera, M, Wierzchowiecki, M, Wodniecki, J, Wojciechowoski, D, Wrabec, K, Wysocki, H, Gomes, Rs, Ceia, Mf, Lousada, N, Campos, Jmm, Providencia, La, de Moura ALZC, Marejev, Vj, Aronov, Dm, Arutjunov, Gp, Bart, Bj, Basechikin, Ss, Belenkov, Jn, Beloussov, Jb, Bokeria, Oa, Charchogljan, Ra, Doschytsin, V, Fedorova, Ta, Glezer, Mg, Gorbachenkov, A, Gorshkov, Gospodarenko, Al, Ivashkin, Vt, Ivleva, Aj, Kyrichenko, Aa, Lavrov, Aa, Lazebnik, Lb, Marynov, A, Mazaev, Vp, Polejev, Nr, Shpektor, Sidorenko, Ba, Sobolev, Ke, Starodoubtsev, Ak, Storozhakhov, Gi, Syrkin, Al, Zodionchenko, Vs, Zvereva, Tv, Murin, J, Kaliska, G, Rybar, R, Valle, V, Artaza, M, Conthe, P, Cruz, Jm, Garcia Moll, M, Lopez Sendon JL, Martinez, A, Monzon, F, Ribas, M, Roig, E, Roldan, I, Hoglund, C, Ekdahl, S, Hjelmaeus, L, Lindberg, K, Lofdahl, P, Ulvenstam, G, Warselius, L, Follath, F, Anghern, W, Dubach, P, Erne, P, Gallino, A, Moccetti, T, Jmouro, Av, Dargie, Hj, Erdmann, E, Lechat, P, Sendon, Jll, Mareyev, V, Sadowski, Z, Seabra Gomes RJ, Zannad, F, Wehrlen Grandjean, M, Funck Brentano, C, Hansen, S, Hohnloser, S, Vanoli, E, Jaillon, P, De Baker, G, Dahlstrom, U, Hill, C, Leizorovicz, A, Burgnard, F, Rolland, C, Wiemann, H, Verkenne, P, Arab, T, Cussac, N, Dussous, V, Haise, S, and Funck Brentano, C.

Subjects
H Social Sciences (General), medicine.medical_specialty, Cost-Benefit Analysis, Adrenergic beta-Antagonists, METOPROLOL, Placebo, THERAPY, Indirect costs, Pharmacoeconomics, Pharmacotherapy, RANDOMIZED INTERVENTION TRIAL, PHARMACOECONOMICS, Germany, Health care, Bisoprolol, Humans, Medicine, Outpatient clinic, Prospective Studies, Intensive care medicine, health care economics and organizations, Heart Failure, CARVEDILOL, business.industry, MORTALITY, Diagnosis-related group, United Kingdom, Chemotherapy, Adjuvant, MERIT-HF, HOSPITALIZATION, MINIMIZATION, INHIBITORS, France, Quality-Adjusted Life Years, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Background Beta-blockers, used as an adjunctive to diuretics, digoxin and angiotensin converting enzyme inhibitors, improve survival in chronic heart failure. We report a prospectively planned economic analysis of the cost of adjunctive beta-blocker therapy in the second Cardiac Insufficiency BIsoprolol Study (CIBIS II). Methods Resource utilization data (drug therapy, number of hospital admissions, length of hospital stay, ward type) were collected prospectively in all patients in CIBIS . These data were used to determine the additional direct costs incurred, and savings made, with bisoprolol therapy. As well as the cost of the drug, additional costs related to bisoprolol therapy were added to cover the supervision of treatment initiation and titration (four outpatient clinic/office visits). Per them (hospital bed day) costings were carried out for France, Germany and the U.K. Diagnosis related group costings were performed for France and the U.K. Our analyses took the perspective of a third party payer in France and Germany and the National Health Service in the U.K. Results Overall, fewer patients were hospitalized in the bisoprolol group, there were fewer hospital admissions perpatient hospitalized, fewer hospital admissions overall, fewer days spent in hospital and fewer days spent in the most expensive type of ward. As a consequence the cost of care in the bisoprolol group was 5-10% less in all three countries, in the per them analysis, even taking into account the cost of bisoprolol and the extra initiation/up-titration visits. The cost per patient treated in the placebo and bisoprolol groups was FF35 009 vs FF31 762 in France, DM11 563 vs DM10 784 in Germany and pound 4987 vs pound 4722 in the U.K. The diagnosis related group analysis gave similar results. Interpretation Not only did bisoprolol increase survival and reduce hospital admissions in CIBIS II, it also cut the cost of care in so doing. This `win-win' situation of positive health benefits associated with cost savings is Favourable from the point of view of both the patient and health care systems. These findings add further support for the use of beta-blockers in chronic heart failure.

Published
2001

50. Lipid pathway alterations in Parkinson's Disease primary visual cortex

Author

Cheng, Danni, Jenner, Andrew M, Shui, Guanghou, Cheong, Wei Fun, Mitchell, Todd W, Nealon, Jessica, Kim, Woojin Scott, McCann, H, Wenk, Markus R, Halliday, Glenda, Garner, Brett, Cheng, Danni, Jenner, Andrew M, Shui, Guanghou, Cheong, Wei Fun, Mitchell, Todd W, Nealon, Jessica, Kim, Woojin Scott, McCann, H, Wenk, Markus R, Halliday, Glenda, and Garner, Brett

Abstract

Background: We present a lipidomics analysis of human Parkinson’s disease tissues. We have focused on the primary visual cortex, a region that is devoid of pathological changes and Lewy bodies; and two additional regions, the amygdala and anterior cingulate cortex which contain Lewy bodies at different disease stages but do not have as severe degeneration as the substantia nigra. Methodology/Principal Findings: Using liquid chromatography mass spectrometry lipidomics techniques for an initial screen of 200 lipid species, significant changes in 79 sphingolipid, glycerophospholipid and cholesterol species were detected in the visual cortex of Parkinson’s disease patients (n = 10) compared to controls (n = 10) as assessed by two-sided unpaired t-test (p-value ,0.05). False discovery rate analysis confirmed that 73 of these 79 lipid species were significantly changed in the visual cortex (q-value ,0.05). By contrast, changes in 17 and 12 lipid species were identified in the Parkinson’s disease amygdala and anterior cingulate cortex, respectively, compared to controls; none of which remained significant after false discovery rate analysis. Using gas chromatography mass spectrometry techniques, 6 out of 7 oxysterols analysed from both non-enzymatic and enzymatic pathways were also selectively increased in the Parkinson’s disease visual cortex. Many of these changes in visual cortex lipids were correlated with relevant changes in the expression of genes involved in lipid metabolism and an oxidative stress response as determined by quantitative polymerase chain reaction techniques. Conclusions/Significance: The data indicate that changes in lipid metabolism occur in the Parkinson’s disease visual cortex in the absence of obvious pathology. This suggests that normalization of lipid metabolism and/or oxidative stress status in the visual cortex may represent a novel route for treatment of non-motor symptoms, such as visual hallucinations, that are experienced by a majority of

Published
2011

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