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3 results on '"Marzollo, Roberto"'

1. Fosfomycin-Containing Regimens for the Treatment of Central Nervous System Infections in a Neonatal Intensive Care Unit: A Case Series Study.

Author

Lenzi, Angelica, Saccani, Barbara, Di Gregorio, Marco, Rossini, Francesco, Sollima, Alessio, Mulè, Alice, Morucci, Federica, Amadasi, Silvia, Fumarola, Benedetta, Lanza, Paola Antonia, Lorenzotti, Silvia, Van Hauwermeiren, Evelyn, Cavalleri, Elisa, Marzollo, Roberto, Matteelli, Alberto, Signorini, Liana, and Risso, Francesco Maria

Subjects
CENTRAL nervous system infections, LOW birth weight, NEONATAL intensive care units, NEONATAL intensive care, PREMATURE infants
Abstract

Central nervous system infections are among the most severe infectious conditions in the neonatal period and are still burdened by significant mortality, especially in preterm infants and those with a low birth weight or other comorbidities. In this study, we examined the role of fosfomycin-containing antibiotic regimens in neonates with central nervous system infections. We included six neonates over a period of five years: four with meningitis and two with cerebral abscesses. All patients underwent fosfomycin therapy after failing first-line antibiotic regimens. Of the six neonates, two died; two developed neurological and psychomotor deficits and two recovered uneventfully. None of the neonates experienced adverse reactions to fosfomycin, confirming the safety of the molecule in this population. In conclusion, the deep penetration in the central nervous system, the unique mechanism of action, the synergy with other antibiotic therapies, and the excellent safety profile all make fosfomycin an attractive drug for the treatment of neonatal central nervous system infections. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Antiinfective properties of human milk

Author

Chirico, Gaetano, Marzollo, Roberto, Cortinovis, Sheila, Fonte, Chiara, and Gasparoni, Antonella

Subjects
Breast milk -- Chemical properties, Breast milk -- Health aspects, Anti-infective agents -- Research, Food/cooking/nutrition
Abstract

The unfavorable effects of neonatal immunodeficiency are limited by some naturally occurring compensatory mechanisms, such as the introduction of protective and immunological components of human milk in the infant. Breast-feeding maintains the maternal-fetal immunological link after birth, may favor the transmission of immunocompetence from the mother to her infant, and is considered an important contributory factor to the neonatal immune defense system during a delicate and crucial period for immune development. Several studies have reported that breast-feeding, because of the antimicrobial activity against several viruses, bacteria, and protozoa, may reduce the incidence of infection in infants. The protection from infections may be ensured either passively by factors with antiinfective, hormonal, enzymatic, trophic, and bioactive activity present in breast milk, or through a modulator effect on the neonatal immune system exerted by cells, cytokines, and other immune agents in human milk.

Published
2008

3. Peripherally Inserted Central Catheter (PICC) placement in newborns, Italian training program for nurses: preliminary results

Author

Romitti Maria Grazia, Motta Mario, Marzollo Roberto, Pezzotti Elena, Memoli Maria Rosaria, Chirico Gaetano, Codega Alessandra, Dioni Elisabetta, Previdera Roberta, Certi Marina, Titone Carmela, and Aversa Salvatore

Subjects
Pediatrics, medicine.medical_specialty, Neonatal intensive care unit, Data collection, business.industry, education, Scientific literature, medicine.disease, Peripherally inserted central catheter, Intensive care, Meeting Abstract, medicine, Medical emergency, TUTOR, Training program, business, Competence (human resources), computer, computer.programming_language
Abstract

In the Italian Neonatal intensive care Units the positioning of Peripherally Inserted Central Catheters (PICC) is strictly a medical competence, neonatal nurses are the ones fully entrusted of the PICCsmanagement. In 2014 a group of neonatologists and nurses established at the Civil Hospital in Brescia a PICC group; the aim was to review and update the internal procedures but, also to ponder the idea of training nurses to place PICCs. Many were the reasons for this last consideration; to improve the quality and safety of neonatal critical care, to standardize the procedures to reduce errors and complications but also to make neonatal nurses fully aware of their role in PICCs correct management. A course was organized in two phases (lessons and practice) with the aim to provide participants with the knowledge and skills to safely position and manage PICCs. A careful work of review of national and international scientific literature regarding PICCs was carried out, the NICU procedures were updated prior the course onset [1-5]. All the specific topics regarding PICCs were tackled during the first part of the course(theoretical). The second part (practical) was divided in three parts:A) “executor” nurses were supposed to successfully position 4 PICCs under medical supervision, B) “tutor” nurses were asked to correctly position 10 PICCs, C) maintenance of the acquired skills. Data collection forms have been designed to keep records on PICCs placements, management and potential adverse events. Of the 54 nurses working in NICU, 32 (59%) participated actively at the project. At present 20 nurses have started the practical training:6 have completed the A) phase.53 PICCs have been successfully placed by nurses. The medium number of PICC placement for nurse has been 2,65. The training course for nurses has shown a good safety profile, a high success rate, and no post-procedural complications; a questionnaire has been proposed to all the NICU staff to acknowledge their opinions and impact. These preliminary data are promising, but we need to complete the whole program before being able to encourage other centers to follow our steps.

Published
2015

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